1,685 results on '"Hypoglycemic"'
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2. Protective effect of seabuckthorn seed protein on renal function in diabetic mice
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Wang, Hengheng, Xiang, Huan, Sun-Waterhouse, Dongxiao, Shu, Danyang, Cui, Chun, and Wang, Yueqi
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- 2025
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3. Carob pulp flour as an innovative source of bioactive molecules for the preparation of high-value-added jellies
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Spizzirri, Umile Gianfranco, Esposito, Luigi, Caputo, Paolino, Martuscelli, Maria, Gaglianò, Martina, Clodoveo, Maria Lisa, De Luca, Giuseppina, Rossi, Cesare Oliverio, Savastano, Marco, Scarcelli, Eva, Loizzo, Monica Rosa, Restuccia, Donatella, and Aiello, Francesca more...
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- 2024
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4. Polysaccharide from Hemerocallis citrina Borani by subcritical water: Bioactivity, purification, characterization, and anti-diabetic effects in T2DM rats
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Ti, Yongrui, Wang, Weizhen, Zhang, Yanli, Ban, Yüqian, Wang, Xiaoxiao, Wang, Peng, and Song, Zihan
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- 2022
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5. Antihyperglycemic Potential of Dried Powder Combination of Hygrophila auriculata and Cordia macleodii : In Vivo Study in Sprague Dawley Rats.
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Almutairi, Farooq M.
- Abstract
ABSTRACT: Introduction: Hygrophila auriculata (Acanthaceae family) and Cordia macleodii (Boraginaceae family) are two famous Indian plants that had until been unrecognized for their antihyperglycemic effects. This study examined the antihyperglycemic effect of metformin in a rat model of diabetes caused by the alloxan method for dried flower powder of H. auriculata and C. macleodii, both alone and in combination. Materials and Methods: Rat weights ranged from 150-200 g, housed under controlled conditions (25-26°C, 50-55% humidity, 12-hour light/dark cycle) with standard diet and water access. Fresh flowers of H. auriculata and C. macleodii were collected, dried, and powdered. The powders were macerated in methanol, evaporated, and further processed. Acute toxicity was assessed by administering flower powder to rats in doses from 5 mg/kg to 5,000 mg/kg, determining LD50 values per OECD guidelines. Anti-hyperglycemic effects were tested in alloxan-induced diabetic rats, with blood glucose levels measured at intervals after oral administration of the flower powders. The hypoglycemic potential was evaluated using the area under the curve (AUC) method. Results: Five hours after oral treatment, the investigation showed that a mixture of dried flower powder of H. auriculata and C. macleodii significantly reduced blood sugar levels. A key role in modulating the pharmacological action is played by the components derived from plants, including alkaloids and flavonoids. Conclusion: This study will provide light on new avenues for research into the therapeutic treatment of diabetes mellitus via the development of innovative herbal formulations. [ABSTRACT FROM AUTHOR] more...
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- 2024
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6. Unraveling Quercetin's Potential: A Comprehensive Review of Its Properties and Mechanisms of Action, in Diabetes and Obesity Complications.
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Yi, Ruhan, Liu, Yun, Zhang, Xu, Sun, Xiance, Wang, Ningning, Zhang, Cong, Deng, Haoyuan, Yao, Xiaofeng, Wang, Shaopeng, and Yang, Guang
- Abstract
The prevalence of diabetes is escalating alarmingly, placing a significant economic burden on the global healthcare system. The use of chemical substances extracted from plants has been demonstrated to be an effective method for the treatment and control of insulin resistance and Type 2 diabetes mellitus (T2DM). New research indicates that natural phytochemicals present in fruits and vegetables are expected to become drugs for the treatment of diabetes and the prevention of related complications. Quercetin, a widely distributed flavonoid, is well‐known for its antioxidant, anti‐inflammatory, anticancer, and antidiabetic properties. This article provides a comprehensive account of the mechanism of action of quercetin on diabetes and obesity complications in vivo and in vitro. It elucidates the impact of quercetin on various cells. These include hepatocytes, renal cells, skeletal muscle cells, and adipocytes. Furthermore, this article discusses the mechanism of quercetin on organ damage in diabetic mice induced by STZ, alloxan, diet, and spontaneous Type 2 diabetic mice caused by genetic defects. Additionally, it addresses the pharmacokinetics of quercetin and its potential for synergistic effects with existing diabetic drugs. [ABSTRACT FROM AUTHOR] more...
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- 2024
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7. Study on in vitro antioxidant, hypoglycemic, and hypolipidemic activities of mulberry fermented wine brewed with different varieties.
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HUANG Yue, HUANG Chuanshu, YANG Biwen, ZHAO Pei, WANG Mei, ZHOU Hongyuan, LIU Yan, WU Jun, and DAI Hongjie
- Abstract
Fermented wine was brewed with four mulberry varieties respectively, including Da 10, Zhongsang 5801, Jialing 30, and Zijin 6. The antioxidant, hypoglycemic, and hypolipidemic activities in vitro of mulberry fermented wine were studied. Furthermore, the physicochemical indexes (e.g., total phenol and anthocyanin contents, etc.) of different mulberry varieties and their fermented wine were comparatively analyzed. Results showed that the contents of total phenol (2.44 mg GAE/ mL) and anthocyanin (410.79 mg CGE/ L) in Da 10 mulberry fermented wine were significantly higher than those in the other three varieties. In terms of antioxidant activity, the DPPH radical scavenging rate (99.70%) and ferric reduction capacity of Da 10 mulberry fermented wine were the highest, and the ABTS cationic radical scavenging rates of Jialing 30, Zhongsang 5801, and Da 10 mulberry fermented wine were over 95%, which was significantly higher than that of Zijin 6 (81.29%). The ·OH scavenging rates of Da 10 and Zijin 6 mulberry fermented wine were relatively high ( > 85% ). In terms of hypoglycemic activity, Da 10 mulberry fermented wine showed a better effect, and its inhibition rate of α-glucosidase and α-amylase activity was 96. 45% and 68. 13%, respectively. In terms of hypolipidemic activity, Da 10 mulberry fermented wine also had a better binding ability to sodium glycocholate and sodium taurocholate. In summary, all four mulberry fermented wines had good antioxidant activity, inhibition activity of α-glucosidase and α-amylase as well as hypolipidemic activity in vitro. On the whole, Da 10 mulberry fermented wine showed better functional activity. The results of correlation analysis showed that the content of total phenol in mulberry fermented wine was significantly positively correlated with its hypoglycemic activity (P < 0.001), anthocyanin content was significantly positively correlated with DPPH radical scavenging ability and hypolipidemic activity, and total acid content was significantly positively correlated with ·OH scavenging ability. [ABSTRACT FROM AUTHOR] more...
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- 2024
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8. Metabolic Benefits of Phytosterols: Chemical, Nutritional, and Functional Aspects.
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Jiménez, Paula, Bustamante, Andrés, Echeverría, Francisca, Sambra, Verónica, Rincón-Cervera, Miguel Ángel, Farías, Camila, and Valenzuela, Rodrigo
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ENRICHED foods , *STEROLS , *PUBLISHED articles , *FUNCTIONAL foods , *ANIMAL models in research , *PHYTOSTEROLS - Abstract
Plant sterols encompass phytosterols and phytostanols, with over 250 identified types. They've garnered attention in the food industry due to their potential hypocholesterolemic effects. This manuscript offers a current view phytosterols content in foods, their bioaccessibility, bioavailability, and metabolic benefits based on existing preclinical and clinical data. Published articles from 2016 to 2023 regarding the effect of sitosterol, sitostanol, campesterol, campestanol, stigmasterol, and mixed phytosterols on preclinical models and clinical trials were included. Food and technology-related issues were also discussed. Phytosterols's bioavailability in food is limited, exhibiting vulnerability to oxidation, low water solubility, and a distinctive taste. Nevertheless, various technological approaches have been devised to enhance its inclusion in food, ensuring adequate doses for harnessing its cholesterol-lowering potential. This effect has been extensively researched, alongside its hypoglycemic and anti-inflammatory properties. There's a need to create novel functional foods enriched with phytosterols to attain the daily dosage required to leverage its hypercholesterolemic, hypoglycemic, anti-inflammatory, and other ongoing beneficial effects. [ABSTRACT FROM AUTHOR] more...
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- 2024
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9. Isolation, structural characterization, and hypoglycemic activity of polysaccharides from the stems of Panax ginseng C. A. Meyer.
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Xu, Weiwei, Zhou, Wei, Sun, Jinfeng, Chen, Weiwei, Wu, Xuanye, Guan, Tong, Zhao, Yilin, Yang, Pengcheng, Hu, Zhengyu, and Li, Gao
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GINSENG ,PRECIPITATION (Chemistry) ,COLUMN chromatography ,VALUE (Economics) ,POLYSACCHARIDES - Abstract
The purpose of this study was to obtain polysaccharides from Panax ginseng C. A. Meyer stems (PGSPs), agro-byproducts with development potential, and fully explore the potential value in P. ginseng stems. Two novel polysaccharides firstly from P. ginseng stems (PGSP-1 and PGSP-2) were obtained by water extraction and alcohol precipitation method and column chromatography, and then characterized by FT-IR, HPGPC, HPLC, SEM, TGA, GC–MS and NMR. The results demonstrated that PGSP-1 (Mw = 723.83 kDa) and PGSP-2 (Mw = 620.48 kDa) were characterized →4)- β -D-Gal p -(1→, →6)- α -D-Glc p -(1 → and →2)- α -L-Rha p -(1 → as the skeleton, →4,6)- β -D-Gal p -(1 → and →2,6)- α -D-Man p -(1 → as the cross junction, α -L-Araf-(1 → as the terminal unit, and PGSP-1 still contained →4)- β -D-Gal p , while PGSP-2 contained →4)- β -D-Xyl p -(1→, →3)- β -D-Glc p A-(1→, →4)- β -D-Gal p A-(1 →) and α -D-Glc p -(1→, with different microstructures and thermal stability. And the results of hypoglycemic activity revealed that both PGSP-1 and PGSP-2 showed excellent inhibitory activity against α -glucosidase and α -amylase, in which PGSP-2 had the better performance. The inhibition kinetics result showed that PGSPs on α -glucosidase and α -amylase were non-competitive type and mixed type inhibition. This study provided a theoretical basis for making full use of and exploiting the economic value of agro-byproducts such as P. ginseng stems and offered a theoretical reference for the effective utilization of PGSP as a functional component to prevent and reduce T2DM. [ABSTRACT FROM AUTHOR] more...
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- 2024
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10. Ethnopharmacological Study of Garrya laurifolia and Its Antidiabetic Effect in Rats.
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Estévez-Carmona, María Mirian, Pablo-Pérez, Saudy Saret, Almanza-Cruz, Jesús Eduardo, Meléndez-Camargo, María Estela, Arrieta-Baez, Daniel, Cristóbal-Luna, José Melesio, and Franco-Colín, Margarita
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CHLOROGENIC acid ,CITATION analysis ,PHENOLS ,FLAVONOIDS ,LUTEOLIN ,PHYTOCHEMICALS - Abstract
This study aimed to scientifically validate the traditional use of Garrya laurifolia (Gl) leaves as an antidiabetic agent attributed to a community in Mexico. The descriptive ethnobotanical study was conducted in San Miguel Tecpan, a municipality of Jilotzingo, State of Mexico, Mexico, where a structured questionnaire was applied to 44 inhabitants. In vivo studies evaluated the acute oral toxicity of Gl leaves in murine and the effects of a leaf infusion on glycemia in normoglycemic and diabetic rats; in addition, the interaction between Gl and metformin (Met) was also evaluated. The in vitro antioxidant activity of Gl was determined. The phytochemical screening and quantification of phenolic and flavonoid content of Gl leaves were performed. Gl had a high relative frequency of citation (0.68) among respondents. Gl had a low acute toxicity risk with LD
50 > 5000 mg/kg. The extract had no hypoglycemic effect in normoglycemic rats, but it did have hypoglycemic and antihyperglycemic effects (250 and 500 mg/kg) in diabetic rats. The interaction between Gl (500 mg/kg) + Met (300 mg/kg) resulted in antidiabetic synergism. Gl showed strong antioxidant activity (93.1 ± 0.4%). Phytochemical screening revealed the presence of alkaloids, flavonoids, and some other phenolic compounds. The total phenol content was 77.9 ± 0.6 mg EQ/g and 87.7 ± 0.7 mg EAG/g, and the flavonoids content was 5.32 ± 0.2 mg EQ/g. UHPLC-MS/MS analysis identified chlorogenic acid, rutin, aucubin, luteolin 7-O-neohesperoside, and myricitrin. The findings support the potential use of Gl as a safe and effective antidiabetic agent. [ABSTRACT FROM AUTHOR] more...- Published
- 2024
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11. UPLC-Q-Orbitrap HRMS技术分析荔枝叶不同 极性部位化学成分及体外降血糖活性比较.
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梁洁, 陆春莲, 黄冬芳, 郑飘雪, 梁炎丽, 谢晶晶, 彭嘉文, 马玉明, 魏江存, and 秦祖杰
- Abstract
Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
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- 2024
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12. Development of Mussaenda frondosa sepal infused functional tea with enhanced antioxidant and alpha-amylase inhibitory activities
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Nafla Faleel, Thilini Kananke, and Namal Perera
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Added value ,Antioxidant ,Herbal tea ,Hypoglycemic ,Mussaenda frondosa ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Abstract Mussaenda frondosa (MF) is an edible species of the genus Mussaenda (Rubiaceae) that contains a wide array of medicinal compounds. The present study was conducted to evaluate the physicochemical and functional properties of the MF sepals and to develop a novel herbal tea with improved functional properties. Remarkably high antioxidant and α-amylase inhibitory activities were exhibited by water and ethanol extracts of MF, attributed to their high phenolic and flavonoid contents. None of the extracts showed toxicity, as evaluated by the brine shrimp lethality assay. A tea was formulated by blending different proportions (30, 40 and 50%) of dry sepals of MF with black tea. The sensory analysis showed a significantly high level of acceptance for the formula containing 40% MF (MFT-40) with augmented phenolic contents (138.82 ± 0.21 mg GAE/g), antioxidant (DPPH scavenging activity with IC50 of 12.23 ± 0.45 µg/mL), and hypoglycemic activities (α-amylase inhibition with IC50 of 104.80 ± 0.59 µg/mL) compared to the black tea control (with the values of 128.47 ± 0.13 mg GAE/g, 18.70 ± 0.68 µg/mL and 153.07 ± 0.61 µg/mL respectively). This study revealed the potential use of MF as a source of antioxidants for the development of new functional teas with enhanced health benefits. more...
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- 2024
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13. Optimization of Polysaccharides Extraction from the Peels of Akebia trifoliate and Evaluation of Its in Vitro Antioxidant and Hypoglycemic Activity
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Yongling LIU, Xianglian LIU, Xin TAO, Wei YANG, and Su XU
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akebia trifoliate peels ,polysaccharides ,extraction process ,antioxidant ,hypoglycemic ,Food processing and manufacture ,TP368-456 - Abstract
The aim of this research was to optimize the polysaccharides extraction process from the peels of Akebia trifoliate, and evaluate its in vitro antioxidant and hypoglycemic activity. The ultrasonic-assisted extraction process of polysaccharides from the peels of Akebia trifoliate was optimized using single-factor combined with orthogonal experiment. The antioxidant activity of polysaccharides from the peels of Akebia trifoliate was investigated by using DPPH radical scavenging rate and total reducing ability as the indicators. The hypoglycemic activity of polysaccharides from the peels of Akebia trifoliate was explored using α-glucosidase and α-amylase inhibition rate as the indicators. The results demonstrated that the optimal ultrasonic-assisted extraction process of polysaccharides from the peels of Akebia trifoliate was ultrasound power 280 W, ultrasound time 60 min, extraction temperature 50 ℃, solid-liquid ratio 1:40 g/mL, respectively. Under the optimal process condition, the extraction rate of polysaccharides from the peels of Akebia trifoliate was 5.91%±0.20%. Within the measured concentration range, polysaccharides from the peels of Akebia trifoliate had the preferable DPPH radical scavenging and reducing ability. In addition, the IC50 values of polysaccharides from the peels of Akebia trifoliate and VC for scavenging DPPH free radicals were 0.329 and 0.077 mg/mL, separately. The IC50 values of polysaccharides from the peels of Akebia trifoliate for inhibiting α-glucosidase and α-amylase activity were 0.386 and 0.307 mg/mL, respectively. This research proved that the polysaccharides from the peels of Akebia trifoliate extracted by this optimal process had better in vitro antioxidant and hypoglycemic activity. more...
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- 2024
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14. Composition Characteristics and Hypoglycaemic Activity of Phospholipids in Krill Oil as Determined by High-Resolution Mass Spectrometry and Zebrafish
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LIU Huiru, LI Wenyu, CHEN Liguo, WANG Hao, ZHOU Fang, HAN Liwen
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krill oil ,phospholipid ,high-resolution mass spectrometry ,hypoglycemic ,zebrafish model ,Food processing and manufacture ,TP368-456 - Abstract
In this study, in order to investigate the phospholipid composition characteristics and hypoglycemic activity of krill oil, we determined the content of total phospholipids in krill oil by a colorimetric method, examined the phospholipid composition by high-resolution mass spectrometry, and then applied the mass spectral fragmentation pattern and the databases Lipidmaps and Lipidblast for structural analysis. Furthermore, we evaluated the effect of krill oil on blood glucose, biochemical indexes and gene expression levels related to the regulation of blood glucose in a zebrafish model of hyperglycemia induced by the combined treatment of alloxan and sucrose, and explored the potential sites of hypoglycemic action of krill oil-specific phospholipid docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) by molecular docking. The results showed that the content of phospholipids in cold-extracted krill oil was 57.57%, and a total of 63 phospholipids were identified, of which phosphatidylcholine (PC) was the most abundant. Krill oil significantly reduced blood glucose concentration, elevated insulin and glycogen levels, inhibited the expression of FOXO1/PCK1/G6PC, and promoted the expression of GLUT4 in hyperglycemic zebrafish. Molecular docking revealed that DHA and EPA in krill oil might act at the FOXO1/PCK1/G6PC sites, suggesting close relationship between the phospholipid components and the hypoglycemic activity of krill oil. In summary, this study found that cold-extracted krill oil is rich in phospholipids and is a potential natural product with good hypoglycemic effect. more...
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- 2024
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15. Hypoglycemic Effect of Irradiation Se-enriched A.auricularia Polysaccharide on Type 1 Diabetes Mice
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Shuang LIU, Meng QU, Xin QI, Changcheng JI, and Chengbi CUI
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se-enriched a.auricularia ,polysaccharide ,irradiation ,pi3k/akt/mtor signaling pathway ,hypoglycemic ,Food processing and manufacture ,TP368-456 - Abstract
To investigate different irradiation doses of Se-enriched A.Auricularia polysaccharide (SAAP) in type 1 diabetes mellitus (T1DM) mice. In this study, extraction of polysaccharides from selenium-enriched fungus was carried out after 60Co-γ-ray irradiation treatment. The optimal extraction conditions of SAAP were optimized by response surface methodology. The optimal irradiation dose was selected for the study of in vivo hypoglycemia by comparing the hypoglycemic effect of SAAP under different irradiation doses. C57BL/6 T1DM mice model was established by injecting streptozotocin (STZ) to evaluate the effects of fasting blood glucose (FBG), oral glucose tolerance (OGTT), and SAAP on the glucolipid metabolism and the regulation of oxidative stress in T1DM mice. The results showed that after response surface optimization, the optimal extraction conditions for SAAP: Material-liquid ratio of 37.98:1 mL/g, extraction temperature of 97.94 ℃, extraction time of 3.42 h. The optimal parameters were as follows: liquid-material ratio of 38:1 mL/g, extraction temperature 98 ℃, extraction time of 3.5 h, and SAAP concentration of 0.73 mg/mL. SAAP could improve the symptoms of polydipsia, polyphagia and weight loss in T1DM mice (P more...
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- 2024
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16. Hypoglycemic Effect of Guar Gum Manno-Oligosaccharides on Streptozotocin-Induced Diabetic Mice
- Author
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CHENG Jiaobo, LI Yanxiao, WANG Nannan, YAN Qiaojuan, JIANG Zhengqiang
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guar gum manno-oligosaccharides ,hypoglycemic ,glucose and lipid metabolism ,signaling pathway ,Food processing and manufacture ,TP368-456 - Abstract
Objective: To study the hypoglycemic effect and mechanism of guar gum manno-oligosaccharides (GMOS) on streptozotocin-induced diabetic mice. Methods: GMOS was administered to diabetic mice for 6 weeks, and the changes in body mass and insulin resistance were monitored. Furthermore, indicators of glucose and lipid metabolism such as glucose (GLU), insulin (INS), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were determined. Hepatic histopathological changes were observed, and the expression of proteins involved in the adenosine monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) signaling pathway and the activity of antioxidant enzymes in the liver were detected. Results: GMOS effectively relieved the body mass loss of diabetic mice, significantly alleviated glucose tolerance (30.3%) and enhanced insulin sensitivity (34.6%). Compared with the model group, GMOS decreased the levels of GLU, glycosylated serum protein (GSP) and LDL-C by 38.6%, 29.5%, and 27.3%, respectively, and increased the levels of insulin and HDL-C significantly. Moreover, GMOS reduced oxidative damage, activated the AMPK/PGC-1α signaling pathway, and improved the activities of superoxide dismutase (SOD) and catalase (CAT) in the liver. Conclusion: GMOS could reduce blood glucose and mitigate glucose and lipid metabolism disorder and oxidative stress caused by diabetes mellitus, indicating its potential as a functional food ingredient against diabetes. more...
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- 2024
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17. Proposed mechanisms of action participating in the hypoglycemic effect of the traditionally used Croton guatemalensis Lotsy and junceic acid, its main compound.
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Daniela Moreno-Vargas, Angelina, Andrade-Cetto, Adolfo, Artemisa Espinoza-Hernández, Fernanda, and Mata-Torres, Gerardo
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TYPE 2 diabetes ,CHLOROGENIC acid ,PHOSPHOPROTEIN phosphatases ,INSULIN resistance ,BLOOD sugar ,INSULIN - Abstract
Croton guatemalensis Lotsy (Euphorbiaceae) is an important traditional medicine that is used by the Cakchiquels of Guatemala to control hyperglycemia in patients with type 2 diabetes. Previous studies have shown that administration of this plant induces an acute hypoglycemic effect during fasting and that the main compound is junceic acid, a diterpenoid with a clerodane skeleton; however, junceic acid has not been reported to have hypoglycemic activity in the literature. As the mechanisms involved in the hypoglycemic effect of C. guatemalensis remain unknown, the objective of the present investigation was to elucidate the hypoglycemic mechanisms of this species, as well as its major compound, junceic acid. The results indicated that, similar to complete extract, junceic acid exhibited a hypoglycemic effect in hyperglycemic rats. Both C. guatemalensis extract and junceic acid inhibited the activity of two rate-limiting enzymes involved in hepatic glucose production; however, compared with chlorogenic acid, junceic acid had a more potent effect on glucose-6-phosphatase levels than chlorogenic acid, which was used as a positive control. Furthermore, both fasting and postprandial insulin levels decreased in healthy and hyperglycemic rats despite reduced blood glucose levels in both metabolic states, suggesting a potential insulin-sensitizing effect. However, neither of these compounds potentiated the effect of insulin in insulin tolerance tests nor inhibited the enzyme activity of protein tyrosine phosphatase 1B, a negative regulator of the insulin pathway. Therefore, the insulin-sensitizing effect is thought to be independent of insulin and mediated by potential activation of the AMP-activated protein kinase pathway. The specific activation of this master regulator in β-cells results in the inhibition of insulin secretion in a healthy state and the restoration of the insulin response under conditions of glucotoxicity; these effects were observed after the administration of the extract and junceic acid in healthy and hyperglycemic rats. Overall, the main findings of this study establish a basis of the mechanisms of action of C. guatemalensis and its main compound, junceic acid, in terms of their hypoglycemic effect. [ABSTRACT FROM AUTHOR] more...
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- 2024
- Full Text
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18. Proposed mechanisms of action participating in the hypoglycemic effect of the traditionally used Croton guatemalensis Lotsy and junceic acid, its main compound.
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Moreno-Vargas, Angelina Daniela, Andrade-Cetto, Adolfo, Espinoza-Hernández, Fernanda Artemisa, and Mata-Torres, Gerardo
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TYPE 2 diabetes ,CHLOROGENIC acid ,PHOSPHOPROTEIN phosphatases ,INSULIN resistance ,BLOOD sugar ,INSULIN - Abstract
Croton guatemalensis Lotsy (Euphorbiaceae) is an important traditional medicine that is used by the Cakchiquels of Guatemala to control hyperglycemia in patients with type 2 diabetes. Previous studies have shown that administration of this plant induces an acute hypoglycemic effect during fasting and that the main compound is junceic acid, a diterpenoid with a clerodane skeleton; however, junceic acid has not been reported to have hypoglycemic activity in the literature. As the mechanisms involved in the hypoglycemic effect of C. guatemalensis remain unknown, the objective of the present investigation was to elucidate the hypoglycemic mechanisms of this species, as well as its major compound, junceic acid. The results indicated that, similar to complete extract, junceic acid exhibited a hypoglycemic effect in hyperglycemic rats. Both C. guatemalensis extract and junceic acid inhibited the activity of two rate-limiting enzymes involved in hepatic glucose production; however, compared with chlorogenic acid, junceic acid had a more potent effect on glucose-6-phosphatase levels than chlorogenic acid, which was used as a positive control. Furthermore, both fasting and postprandial insulin levels decreased in healthy and hyperglycemic rats despite reduced blood glucose levels in both metabolic states, suggesting a potential insulin-sensitizing effect. However, neither of these compounds potentiated the effect of insulin in insulin tolerance tests nor inhibited the enzyme activity of protein tyrosine phosphatase 1B, a negative regulator of the insulin pathway. Therefore, the insulin-sensitizing effect is thought to be independent of insulin and mediated by potential activation of the AMP-activated protein kinase pathway. The specific activation of this master regulator in β-cells results in the inhibition of insulin secretion in a healthy state and the restoration of the insulin response under conditions of glucotoxicity; these effects were observed after the administration of the extract and junceic acid in healthy and hyperglycemic rats. Overall, the main findings of this study establish a basis of the mechanisms of action of C. guatemalensis and its main compound, junceic acid, in terms of their hypoglycemic effect. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
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19. 功效型米粉对高脂诱导高血糖小鼠的 降血糖作用研究.
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李育坤, 陶 悦, 韩慧缃, 熊志伟, 陈 炎, and 梁 伟
- Abstract
Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
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- 2024
- Full Text
- View/download PDF
20. 微粉碎对茯茶理化特性及体外 降糖降脂活性的影响.
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杨文娟, 王若彤, 李根, 程越, 李佳蕊, 冯龙, 王静, 曾桥, and 余郑绿
- Abstract
This article used Fu tea as raw material to compare the physical properties, micro-structure, active ingredient content and in vitro antioxidant, hypoglycemic and hypolipidemic activities of Fu tea powder with different particle sizes after micro-crushing to determine the optimal grinding degree of Fu tea powder. The results showed that the particle size D50 of 200 mesh Fu tea powder was 76.45±4.32 µm, the angle of repose was 50.3°, the slip angle was 47.0°, the water holding capacity was 2. 477 g/g, the oil holding capacity was 1.934 g/g, and the polysaccharide content was 11.9%, the polyphenol content was 37.1%, the DPPH clearance rate was 80.4%, the a-glucosidase inhibition rate was 72.7%, the cholate binding rate was 71.6%, and 200 mesh is the optimal crushing size of Fu tea powder. This study will provide a theoretical reference for raw material processing of Fu tea powder hypoglycemic and hypolipidemic functional food. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
21. Impact of Thermal Processing on the Structure, Antioxidant Properties and Hypoglycemic Activities of Sweet Potato Polysaccharides.
- Author
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Liu, Chuan, Miao, Yu, Zhou, Wenjia, Ma, Yiming, Guo, Wenkui, and Li, Aili
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SWEET potatoes ,INFRARED spectra ,CHEMICAL bonds ,FUNCTIONAL groups ,ANTIOXIDANTS - Abstract
In this study, three kinds of thermal treatments were applied to sweet potatoes: steaming (100 °C, 20 min), frying (150 °C, 10 min), and baking (200 °C, 30 min). We analyzed the changes in the physicochemical structure, antioxidant properties, and hypoglycemic activities of sweet potato polysaccharides between untreated and heat-treated samples. The results showed that the polysaccharides of all sweet potatoes (untreated and heat-treated) were composed of pyranose structures, had low protein content, and shared the same monosaccharide composition. Infrared spectra showed that the three thermal processing treatments had no significant effect on the functional groups or chemical bonding of sweet potato polysaccharides. In addition, all four polysaccharides exhibited dose-dependent antioxidant and hypoglycemic activities. The above experimental results suggest that thermal processing did not affect the physicochemical, antioxidant, or hypoglycemic activities of sweet potato polysaccharides. [ABSTRACT FROM AUTHOR] more...
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- 2024
- Full Text
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22. Optimization of Polysaccharides Extraction from the Peels of Akebia trifoliate and Evaluation of Its in Vitro Antioxidant and Hypoglycemic Activity.
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LIU Yongling, LIU Xianglian, TAO Xin, YANG Wei, and XU Su
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POLYSACCHARIDES ,FREE radicals ,RADICALS (Chemistry) ,ULTRASONIC imaging ,ANTIOXIDANTS - Abstract
The aim of this research was to optimize the polysaccharides extraction process from the peels of Akebia trifoliate, and evaluate its in vitro antioxidant and hypoglycemic activity. The ultrasonic-assisted extraction process of polysaccharides from the peels of Akebia trifoliate was optimized using single-factor combined with orthogonal experiment. The antioxidant activity of polysaccharides from the peels of Akebia trifoliate was investigated by using DPPH radical scavenging rate and total reducing ability as the indicators. The hypoglycemic activity of polysaccharides from the peels of Akebia trifoliate was explored using α-glucosidase and α-amylase inhibition rate as the indicators. The results demonstrated that the optimal ultrasonic-assisted extraction process of polysaccharides from the peels of Akebia trifoliate was ultrasound power 280 W, ultrasound time 60 min, extraction temperature 50 °C, solid-liquid ratio 1:40 g/mL, respectively. Under the optimal process condition, the extraction rate of polysaccharides from the peels of Akebia trifoliate was 5.91%±0.20%. Within the measured concentration range, polysaccharides from the peels of Akebia trifoliate had the preferable DPPH radical scavenging and reducing ability. In addition, the IC
50 values of polysaccharides from the peels of Akebia trifoliate and VC for scavenging DPPH free radicals were 0.329 and 0.077 mg/mL, separately. The IC50 values of polysaccharides from the peels of Akebia trifoliate for inhibiting α-glucosidase and α-amylase activity were 0.386 and 0.307 mg/mL, respectively. This research proved that the polysaccharides from the peels of Akebia trifoliate extracted by this optimal process had better in vitro antioxidant and hypoglycemic activity. [ABSTRACT FROM AUTHOR] more...- Published
- 2024
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23. Optimizing the Brewing Process, Metabolomics Analysis, and Antioxidant Activity Analysis of Complexed Hongqu Rice Wine with Kiwiberry.
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Wang, Mengze, Liu, Yuxin, Guo, Xing, Ding, Yuping, and Liu, Dejiang
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RESPONSE surfaces (Statistics) ,SODIUM cholate ,ANTIOXIDANT analysis ,FLAVONOIDS ,FUNCTIONAL foods ,RICE wines - Abstract
Hongqu rice wine is a traditional Chinese yellow wine produced from a single ingredient. To enhance the competitiveness of the product and better adapt to market development trends, the development of a complexed Hongqu rice wine using a variety of ingredients is necessary to enhance the nutritional value of the product and diversify its flavor. This study explored production technology for the development of a complexed Hongqu rice wine using kiwiberry as the raw material. The mixed fermentation process was optimized using single-factor experiments and response surface methodology (RSM). The optimal conditions were a juice addition time of 93 h, a fermentation temperature of 31 °C, and a juice addition amount of 75 g/100 g. Under these conditions, the complexed Hongqu rice wine had an alcohol content of 8.7% vol, a total phenolic content of 0.42 mg GAE/mL, and a total flavonoid content of 0.32 mg CE/mL. In total, 27 metabolites were identified. The relative levels of 15 metabolites, including quercetin-3-glucoside and rutin, increased significantly after the adding of the kiwiberry (VIP > 1.0, p < 0.05, FC > 2). Antioxidant activity experiments showed that the Hongqu rice wine had notable antioxidant capacity and that adding the kiwiberry significantly enhanced this capacity. Additionally, the complexed Hongqu rice wine exhibited hypoglycemic and bile acid-binding properties. It achieved 78.68 ± 0.44% inhibition of α-amylase and 58.02 ± 0.50% inhibition of α-glucosidase. The binding activities with sodium glycocholate, sodium cholate, and sodium taurocholate were 40.25 ± 0.64%, 49.08 ± 1.05%, and 60.58 ± 0.80%, respectively. Consequently, a complexed Hongqu rice wine rich in quercetin-3-glucoside and rutin, with notable antioxidant activities, was developed. This wine has potential applications in functional food development. [ABSTRACT FROM AUTHOR] more...
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- 2024
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24. Phytochemical analysis, identification of bioactive compounds using GC-MS, in vitro and in silico hypoglycemic potential, in vitro antioxidant potential, and in silico ADME analysis of Chlorophytum comosum root and leaf.
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Kavya, P., Theijeswini, R. C., Gayathri, M., Shah, Abdul Bari, Majeed, Salman, and Khan, Mueen Alam
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PLANT extracts , *BIOACTIVE compounds , *ALDOSE reductase , *TYPE 2 diabetes , *MEDICAL sciences , *PHENOL oxidase - Abstract
Chlorophytum comosum is a plant with medicinal potential traditionally used to treat different diseases. The present study aimed to determine the bioactive compounds, hypoglycemic and antioxidant potential of C. comosum root and leaf. The ethyl acetate extracts of C. comosum root and leaf were analyzed by GC-MS to determine the bioactive compounds. The hypoglycemic potential of the extracts was evaluated by α-amylase, α-glucosidase, glucose diffusion inhibitory assays, and glucose adsorption assay. The ethyl acetate extract of C. comosum root inhibited α-amylase, α-glucosidase, and glucose diffusion in a concentration-dependent manner with IC50 values of 205.39 ± 0.15, 179.34 ± 0.3 and 535.248 μg/mL, respectively, and the leaf extract inhibited α-amylase and α-glucosidase enzymes with IC50 values of 547.99 ± 0.09, and 198.18 ± 0.25 μg/ mL respectively. C. comosum root and leaf extracts also improved glucose adsorption. Heptadecanoic acid and dodecanoic acid were identified as potential compounds with hypoglycemic properties through molecular docking. The extracts were also assessed for their antioxidant activity using DPPH, ABTS, and FRAP assays. C. comosum root and leaf extracts were also able to scavenge DPPH radicals with IC50 values of 108.37 ± 0.06 and 181.79 ± 0.09 MM and ABTS radicals with IC50 values of 126.24 ± 0.13 and 264.409 ± 0.08 μM, respectively. The root and leaf extracts also reduced the ferricyanide complex to ferrocyanide with higher reducing powers of 2.24 ± 0.02 and 1.65 ± 0.03, respectively. The results showed that the ethyl acetate extract of C. comosum root has significant antioxidant and hypoglycemic potential compared to the leaf extract. Thus, it can also be studied to isolate the potential compounds with antihyperglycemic activities. [ABSTRACT FROM AUTHOR] more...
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- 2024
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25. 深共熔溶剂提取酒糟多酚类物质及其体外抗氧化、降血糖活性研究.
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晏俊玲, 李茂, 张伟建, 赵佳伟, 覃凤阳, 赵东, and 郑佳
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HIGH performance liquid chromatography ,RESPONSE surfaces (Statistics) ,CHOLINE chloride ,FREE radicals ,RADICALS (Chemistry) - Abstract
Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
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- 2024
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26. 辐照富硒木耳多糖对 1 型糖尿病小鼠的 降血糖作用研究.
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刘 爽, 曲 孟, 齐 欣, 及长城, and 崔承弼
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TYPE 1 diabetes ,TUMOR necrosis factors ,INTERLEUKIN receptors ,BLOOD sugar ,RESPONSE surfaces (Statistics) - Abstract
Copyright of Science & Technology of Food Industry is the property of Science & Technology of Food Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
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- 2024
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27. 基于高分辨质谱及斑马鱼模型的磷虾油磷脂 组成特征及降血糖活性分析.
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刘慧茹, 李文玉, 陈立国, 王 昊, 周 芳, and 韩利文
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KRILL oil ,BLOOD sugar ,DOCOSAHEXAENOIC acid ,NATURAL products ,GENE expression ,EICOSAPENTAENOIC acid - Abstract
Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
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- 2024
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28. Antidiabetic and Anti-Inflammatory Effect of Cinnamomum cassia Oil in Alloxan-Induced Diabetic Rats.
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Cordero-Pérez, Paula, Hernández-Cruz, Flor Edith, Garza-Guzmán, Daniel, Moreno-Peña, Diana Patricia, Sánchez-Martínez, Concepción, Torres-González, Liliana, Muñoz-Espinosa, Linda E., Zapata-Chavira, Homero, Cura-Esquivel, Idalia, Serrano-Sandoval, Marisol Idalí, and Rodríguez-Rodríguez, Diana Raquel more...
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BLOOD urea nitrogen , *ALANINE aminotransferase , *SUPEROXIDE dismutase , *LABORATORY rats , *CASSIA (Genus) - Abstract
Diabetes mellitus presents a great diversity of treatments that cause adverse effects; therefore, plants are a source of compounds that may have fewer adverse effects; Cinnamomum cassia (C. cassia) has compounds with potential antidiabetic activity. The objective was to evaluate the antidiabetic effect of C. cassia oil (CCO) and its impact on oxidative stress in Wistar rats. Five groups were evaluated: (1) sham (SH), (2) 300 mg/kg CCO (CCO), (3) diabetic (D) induced with alloxan, (4) D + 300 mg/kg of CCO (D + CCO), and (5) D + 500 mg/kg of metformin (D + MET); all were treated for 5 days. CCO did not show alteration in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) vs. SH. D + CCO vs. D significantly reduced glucose (333 ± 109 vs. 458 ± 81 mg/dL), ALT (66 ± 15 vs. 160 ± 54 U/L), AST (119 ± 26 vs. 243 ± 104 U/L), and blood urea nitrogen (18.8 ± 2.3 vs. 29.2 ± 6.9 mg/dL). No significant changes were observed in D + CCO vs. D in malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD), whereas a significant reduction in MDA and GSH was achieved in D + MET, with an increase in SOD. There was a reduction in Rela and Gpx in D + CCO and D + MET vs. D. CCO has antidiabetic and anti-inflammatory effects and reduces ALT, AST, and BUN levels. [ABSTRACT FROM AUTHOR] more...
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- 2024
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29. 正十七茶改善 2 型糖尿病小鼠 β 细胞损伤 及糖脂代谢紊乱.
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李娟, 尹聪, 付锦洲, 刘荆金, 江雪平, and 陈绍文
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GLUCOSE tolerance tests ,BLOOD sugar ,TYPE 2 diabetes ,DIETARY fats ,ALANINE aminotransferase - Abstract
Copyright of Journal of South-Central Minzu University (Natural Science Edition) is the property of Journal of South-Central Minzu University (Natural Science Edition) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
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- 2024
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30. Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara.
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Wang, Zheng, Yu, Zhe-Wei, Zhang, Yi, Wang, Wen-Hui, Wu, Xin-Yi, Liu, Shun-Zhi, Bin, Yan-Lin, Cai, Bang-Ping, Huang, Shi-Yan, Fang, Mei-Juan, Qi, Rong, Li, Ming-Yu, and Qiu, Ying-Kun
- Abstract
In this study, 14 abietene and pimarene diterpenoids were isolated from the woods of Agathis dammara. Among them, 4 new compounds, dammarone A-C and dammaric acid A (1–4), were firstly reported, respectively. The structure of the new compounds was determined by HR ESI–MS and 1D/2D NMR spectroscopy, and their absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. The hypoglycemic effect of all compounds was evaluated by transgenic zebrafish model, and the structure–activity relationship was discussed. Hinokione (7, HO) has low toxicity and significant hypoglycemic effects on zebrafish, the mechanism is mainly by promoting the differentiation of zebrafish pancreatic endocrine precursor cells (PEP cells) into β cells, thereby promoting the regeneration of pancreatic β cells. [ABSTRACT FROM AUTHOR] more...
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- 2024
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31. Spectrum–effect relationship between HPLC fingerprint and hypoglycemic of litchi leaves (Litchi chinensis Sonn) in vitro.
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Liang, Yanli, Xie, Jingjing, Huang, Dongfang, Cao, Yupin, Zheng, Piaoxue, Lu, Chunlian, Ma, Yuming, Peng, Jiawen, Qin, Zujie, and Liang, Jie
- Abstract
Litchi chinensis Sonn (Litchi) has been listed in the Chinese Pharmacopeia, and is an economically and medicinally valuable species within the family Sapindaceae. However, the material basis of its pharmacological action and the pharmacodynamic substances associated with its hypoglycemic effect are still unclear. The predominant objective of this study was to establish the fingerprint profile of litchi leaves and to evaluate the relationship between the components of the high‐performance liquid chromatography (HPLC) fingerprint of litchi leaves, assess its hypoglycemic effect by measuring α‐glucosidase and α‐amylase inhibition, and find the spectrum–effect relationship of litchi leaves by bivariate correlation analysis, Grey relational analysis and partial least squares regression analysis. In this study, the fingerprint of litchi leaves was established by HPLC, and a total of 15 common peaks were identified that clearly calibrated eight components, with P1 being gallic acid, P2 being protocatechuic acid, P3 being catechin, P6 being epicatechin, P12 being rutin, P13 being astragalin, P14 being quercetin and P15 being kaempferol. The similarities between the fingerprints of 11 batches of litchi leaves were 0.766–0.979. Simultaneously, the results of the spectrum–effect relationship showed that the chemical constituents represented by peaks P8, P3, P12, P14, P2, P13, and P11 were relevant to the hypoglycemic effect. [ABSTRACT FROM AUTHOR] more...
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- 2024
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32. Sonchus asper (L.) Hill extracts: phytochemical characterization and exploitation of its biological activities by loading into nanoformulation.
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Parisi, Valentina, Santoro, Valentina, Faraone, Immacolata, Benedetto, Nadia, Vassallo, Antonio, De Tommasi, Nunziatina, Milella, Luigi, Nesticò, Antonio, Maselli, Gabriella, Fadda, Anna Maria, and Caddeo, Carla more...
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EDIBLE wild plants ,LIQUID chromatography-mass spectrometry ,ESSENTIAL amino acids ,LIPOSOMES ,WELL-being - Abstract
Introduction: The current investigation presents a two-fold approach to rediscovering the potential of Sonchus asper as a wild edible plant, both in its raw extract form and as a nanoformulated product. Furthermore, the study aimed to promote the valorization of traditional dishes and contribute to biodiversity conservation and sustainable use of S. asper, thus enhancing economic profits. Methods: Liquid chromatography-mass spectrometry analyses were conducted to characterize the metabolite profile of the raw and cooked leaf extracts, and the extract from discarded leaves. The antioxidant activity, the hypoglycaemic effect and the incorporation into liposomes were evaluated. Results: 38 compounds and 6 essential amino acids were identified. The incorporation into liposomes maximized the health-promoting properties for potential pharmaceutical or food applications. Discussion: The commercialization of S. asper could: (i) contribute to improving the well-being of rural and urban communities, being S. asper a wild edible plant available at low cost, environmentally friendly, resilient, and adaptable; (ii) generate landowner economic returns. [ABSTRACT FROM AUTHOR] more...
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- 2024
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33. 瓜尔豆胶甘露寡糖对链脲佐菌素诱导 糖尿病小鼠的降血糖作用.
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程教擘, 李延啸, 王楠楠, 闫巧娟, and 江正强
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HDL cholesterol ,LDL cholesterol ,BLOOD proteins ,LIPID metabolism ,INSULIN sensitivity ,INSULIN - Abstract
Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
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- 2024
- Full Text
- View/download PDF
34. From waste to wonder: exploring the hypoglycemic and anti-oxidant properties of corn processing by-products.
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Yang, Xiaoqian, Wang, Yuelong, Li, Jingfeng, Tai, Yuxing, Yang, Kunping, Lv, Jingwei, Sun, Jiaming, Zhang, Hui, Ahmed, Dildar, and Shah, Abdul Bari
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ANTIOXIDANTS , *FLAVONOIDS , *MOLECULAR docking , *MOLECULAR dynamics , *WASTE products - Abstract
Introduction: The industrial processing of corn (Zeamays L.) generates byproducts such as corn silk, straw peels, and straw core, which contribute to adverse environmental impacts. Our study aimed to investigate sustainable approaches for mitigating these effects by evaluating the hypoglycemic potential and mechanisms of ethyl acetate fractions derived from these corn derivatives. Methods: We employed glucose consumption assays, high glucose stress tests, UPLC-QE-Orbitrap-MS analysis, molecular docking, and simulations to assess their components and efficacy. Antioxidant capacities were evaluated using DPPH, FRAP, ABTS, and •OH scavenging assays. Results: Notably, the ethyl acetate fraction extracted from straw peels (SPE) exhibited a high concentration of flavonoids and phenolic compounds along with pronounced hypoglycemic activity and antioxidant capacity. SPE significantly enhanced glucose consumption in insulin-resistant HepG2 cells while protecting HUVECs against damage caused by high glucose levels. Molecular docking analyses confirmed the interaction between active compounds and α-glucosidase as well as α-amylase, while molecular dynamic simulations indicated stability at their binding sites. Discussion: In conclusion, the hypoglycemic and antioxidative properties observed in corn by-products such as straw peels, corn silk, and straw core can be attributed to the inhibition of α-glucosidase and α-amylase activities, coupled with their rich phenolic and flavonoid content. These findings highlight the potential of these by-products for applications in healthcare management and their sustainable utilization, demonstrating significant value in the use of agricultural residues. [ABSTRACT FROM AUTHOR] more...
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- 2024
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35. Flavonoids from Ougan (Citrus suavissima Hort. ex Tanaka) peel exert hypoglycemic potency through inhibiting insulin resistance in HepG2 cells and regulating gut microbiota in diabetic mice
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Hongyan Zhou, Shengmin Lu, Meiyu Zheng, and Xiaokun Ouyang
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Ougan (Citrus suavissima Hort. Ex Tanaka) ,Flavonoids ,Hypoglycemic ,Insulin resistance-HepG2 cell ,Gut microbiota ,Diabetic mice ,Nutrition. Foods and food supply ,TX341-641 - Abstract
To fully and value-addedly utilize the citrus peel resource, flavonoids were extracted and purified from peel powder of Ougan (Citrus suavissima Hort. ex Tanaka) using an ultrasonic assisted ethanol solution extraction method and AB-8 macroporous resin purification. The obtained flavonoid extract from peel of Ougan (FEPO) was used for the hypoglycemic experiments in vitro and in vivo on glucose consumption in insulin resistance model HepG2 cells and streptozotocin induced diabetes model mice. A significant reduction of glucose consumption in the model cells while a significant increase in the treated were found in a dose-dependent manner, compared to 5.2241 ± 0.2201 mmol/L of the normal cells (P more...
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- 2024
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36. Isolation, structural characterization, and hypoglycemic activity of polysaccharides from the stems of Panax ginseng C. A. Meyer
- Author
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Weiwei Xu, Wei Zhou, Jinfeng Sun, Weiwei Chen, Xuanye Wu, Tong Guan, Yilin Zhao, Pengcheng Yang, Zhengyu Hu, and Gao Li
- Subjects
agro-byproducts ,Panax ginseng C. A. Meyer stems ,polysaccharides ,preparation ,hypoglycemic ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
The purpose of this study was to obtain polysaccharides from Panax ginseng C. A. Meyer stems (PGSPs), agro-byproducts with development potential, and fully explore the potential value in P. ginseng stems. Two novel polysaccharides firstly from P. ginseng stems (PGSP-1 and PGSP-2) were obtained by water extraction and alcohol precipitation method and column chromatography, and then characterized by FT-IR, HPGPC, HPLC, SEM, TGA, GC–MS and NMR. The results demonstrated that PGSP-1 (Mw = 723.83 kDa) and PGSP-2 (Mw = 620.48 kDa) were characterized →4)-β-D-Galp-(1→, →6)-α-D-Glcp-(1 → and →2)-α-L-Rhap-(1 → as the skeleton, →4,6)-β-D-Galp-(1 → and →2,6)-α-D-Manp-(1 → as the cross junction, α-L-Araf-(1 → as the terminal unit, and PGSP-1 still contained →4)-β-D-Galp, while PGSP-2 contained →4)-β-D-Xylp-(1→, →3)-β-D-GlcpA-(1→, →4)-β-D-GalpA-(1 →) and α-D-Glcp-(1→, with different microstructures and thermal stability. And the results of hypoglycemic activity revealed that both PGSP-1 and PGSP-2 showed excellent inhibitory activity against α-glucosidase and α-amylase, in which PGSP-2 had the better performance. The inhibition kinetics result showed that PGSPs on α-glucosidase and α-amylase were non-competitive type and mixed type inhibition. This study provided a theoretical basis for making full use of and exploiting the economic value of agro-byproducts such as P. ginseng stems and offered a theoretical reference for the effective utilization of PGSP as a functional component to prevent and reduce T2DM. more...
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- 2024
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37. Preparation and activity study of selenium nanoparticles from polysaccharides of Moringa oleifera leaves
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Dong, Fang, Wang, Jing-Yang, Li, Ming-Zhe, Li, Wan-Ran, Wang, Xin, Zheng, Zhao-Yin, Li, Yan-Xia, Li, Ran, Zong, Yan, Liu, Yong-Tao, and Dai, Ying
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- 2024
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38. Integrating mulberry juice and Lactiplantibacillus plantarum TAR4 fermentation to improve antioxidant, anti-inflammatory, and hypoglycemic potential of modified cottage cheese
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Tang, Pei Ling, Chooi, Jia Wei, and Tan, Hui Yin
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- 2024
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39. Hypoglycemic and hepatoprotective activity of Phellinus fastuosus on streptozotocin-induced diabetic rats and carbon tetrachloride-intoxicated rats, respectively
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Hiralal Sonawane, Deepak Shelke, Sagar Arya, Vikram Ghole, Bhaskar Behra, and Subhash Gaikwad
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Phellinus fastuosus ,Hepatoprotective ,Hypoglycemic ,Activities ,Bioactive metabolites ,Therapeutics. Pharmacology ,RM1-950 ,Pharmacy and materia medica ,RS1-441 - Abstract
Abstract Background Phellinus fastuosus is a wood-eating medicinal fungus from Western Ghats of India. Therefore, we investigated hypoglycemic and hepatoprotective effects of P. fastuosus aqueous extract on streptozotocin-induced diabetic and carbon tetrachloride (CCl4) induced hepatotoxicity in rats, respectively. Result As compared to the diabetic control group, a 400 mg/kg dose had significant hypoglycemic effects, including a reduction in blood glucose (24.44%) and gain in body weight. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity reduced by 31.81% and 32.84%, respectively, were also noted, along with decreases in triglycerides (24.32%) and cholesterol (25.89%) levels. The albumin, bilirubin and creatinine levels were also significantly reduced after administration of P. fastuosus extract in diabetic rats. Administration of P. fastuosus extract showed a substantial decrease in the activity of ALT, AST, alkaline phosphatase (ALP), catalase (CAT) and superoxide dismutase (SOD) in addition a decrease in the level of lipid peroxidation (LPO) as compared to CCl4-intoxicated rats. The cumulative effect of CCl4 increased the erythrocyte membrane peroxidation, whereas P. fastuosus extract reduced the cholesterol and increased phospholipid, thus preventing the alteration of membrane fluidity as compared to CCl4-intoxicated rats. FTIR and HR-LC-MS-based metabolic profiling revealed the presence of various functional groups and bioactive metabolites. Conclusion The extract showed the hypoglycemic and hepatoprotective effects due to the presence of various bioactive metabolites. Exploration of therapeutic potential of P. fastuosus using bioassay-guided fractionation is needed. more...
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- 2024
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40. Optimization of Enzymatic-assisted Aqueous Two-phase Extraction Conditions of Polysaccharides from Cordyceps cicadae and Analysis of Its Antioxidant, Hypoglycemic and Hypolipidemic Properties in Vitro
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Jinting LI, Xinyi QIAN, Yidan YONG, Mengmeng WU, Huakai SUN, Yanan WANG, Anhui CHEN, Ying SHAO, and Zaizhong NI
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cordyceps cicadae polysaccharides ,extraction optimization ,antioxidant ,hypoglycemic ,hypolipidemic ,Food processing and manufacture ,TP368-456 - Abstract
Polysaccharides are one of the main constituents of Cordyceps cicadae (C. cicadae), and they show various biological activities. In the present study, C. cicadae fruiting bodies were used as raw materials to extract polysaccharides using an aqueous two-phase system, along with cellulase and pectinase, aiming to provide references for the further development, utilization, and in-depth research of C. cicadae polysaccharides. Effects of cellulase and pectinase addition amounts and (NH4)2SO4 and polyethylene glycol (PEG) mass fractions on the polysaccharide-extraction rates were analyzed by single-factor experiments. The conditions for C. cicadae polysaccharide extraction were optimized by response-surface methodology, and the antioxidant, hypoglycemic, and hypolipidemic properties of the polysaccharides were evaluated in vitro. The optimal conditions for C. cicadae polysaccharide extraction were as follows: Cellulase addition amount 2.01%, pectinase addition amount 2.07%, (NH4)2SO4 mass fraction 17.72%, and PEG mass fraction 20.87%, the polysaccharide-extraction rate reached 25.34% under these conditions. When the C. cicadae polysaccharide concentration was 1.0~5.0 mg/mL, the maximum Fe2+-chelating and ABTS+ radical-clearance abilities were 16.33%±1.68% and 17.38%±3.07%, respectively. The determination of total reducing power showed that the maximum absorbance of C. cicadae polysaccharides was 0.53±0.005. The maximum inhibitory rates of C. cicadae polysaccharides for α-amylase and α-glucosidase activities were 30.96%±4.53% and 49.40%±1.30% respectively, the maximum adsorption rates of C. cicadae polysaccharides for sodium cholate, sodium taurocholate, and cholesterol were 47.24%±1.89%, 44.88%±0.82%, and 70.19%±2.54% respectively. The results indicated that C. cicadae polysaccharides demonstrate effective antioxidant, hypoglycemic, and hypolipidemic abilities in vitro. This study will provide a theoretical basis for developing C. cicadae polysaccharide-related products, especially for clinical applications. more...
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- 2024
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41. Use of two different methods for glucose determination in sheep under normoglycemic, hypoglycemic, and hyperglycemic conditions: an evaluation of practical diagnostic methods in ovines.
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Chenard, Marina Galindo, Bastos, Jade de Menezes Paes, Valle, Matheus Dias, Magalhães da Cunha, Isabelle, Alencar, Nayro Xavier de, Lessa, Daniel Augusto Barroso, Souza, Guilherme Nunes de, Cunha, Nathalie Costa da, and Helayel, Michel Abdalla more...
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BLOOD sugar , *RECEIVER operating characteristic curves , *PETS , *EFFECT of stress on animals , *METABOLIC disorders , *HYPERGLYCEMIA - Abstract
Context: Animals can present abnormal blood glucose concentrations because of various diseases or pathological conditions, stress, or hunger. Early diagnosis prevents complications, economic losses, and death. The use of a portable glucometer (PGM) has been shown to be a good, simple, and practical alternative method with good precision and accuracy for assessing blood glucose in humans and companion animals. Aims: The objective of this work was to evaluate the accuracy and reliability of a portable glucometer (PGM) for assessing glycemia in normoglycemic, hypoglycemic, and hyperglycemic sheep. Methods: Blood glucose was evaluated in 60 normoglycemic, 15 hypoglycemic, and 15 hyperglycemic sheep. Blood samples were collected and analysed within 2 h by using PGM and the enzymatic method (EM). Each test was evaluated for sensitivity, specificity, and the area under the receiver operating characteristic (ROC) curve for two cutoff points, namely, one for hypoglycemia and the other for hyperglycemia. Key results: The results of the Kolmogorov–Smirnov test (P < 0.05) for all groups evaluated did not show a normal distribution for the values evaluated by PGM and EM. Despite the significant difference found between the medians of the methods and the low homogeneity according to the coefficient of variation (CV), there was a homogeneous and linear dispersion of the results. The Bland–Altman test showed that the mean difference between the two methods was close to zero, denoting good agreement, precision, and accuracy of PGM when compared to EM. Conclusions: PGM presents high accuracy and precision for assessing glycemia in sheep, providing satisfactory and reliable results when compared with EM. Implications: The use of PGM facilitates the veterinarian's routine, promoting early diagnosis, field examinations, and monitoring of metabolic diseases. The assessment of glycemia is crucial for diagnosing pathologies, balancing diets and measuring stress in production animals. Portable glucometer (PGM) has been shown to be an effective, simple, practical and accessible tool for measuring blood glucose in goats, cattle and horses, for example. Here we used PGM to assess glycemia in sheep, and found that it provides satisfactory and reliable results when compared with enzymatic method. The use of PGM promotes early diagnosis, field tests and monitoring of metabolic diseases. [ABSTRACT FROM AUTHOR] more...
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- 2024
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42. Hypoglycemic Ability of Sericin-Derived Oligopeptides (SDOs) from Bombyx mori Yellow Silk Cocoons and Their Physiological Effects on Streptozotocin (STZ)-Induced Diabetic Rats.
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Tocharus, Chainarong and Sutheerawattananonda, Manote
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HYPOGLYCEMIA ,GLUCOSE tolerance tests ,LABORATORY rats ,SILKWORMS ,GLYCEMIC control ,INSULIN - Abstract
Patients with diabetes require daily medication to maintain blood sugar levels. Nevertheless, the long-term use of antidiabetics can lose efficacy and cause degeneration in some patients. For long-term diabetes care, integrating natural dietary foods and medicine is being considered. This study investigated the impact of SDOs on blood sugar levels and their physiological effects on diabetic rats. We induced diabetes in male Wistar rats with STZ (50 mg/kg) and then administered an oral glucose tolerance test to determine the SDO dosage comparable to glibenclamide. The rats were divided into nine groups: normal, diabetic, and diabetic with insulin (10 U/kg), glibenclamide (0.6 mg/kg), bovine serum albumin (BSA; 200 mg/kg), soy protein isolate (200 mg/kg), or SDOs (50, 100, and 200 mg/kg). Diabetic rats administered SDOs had a higher body weight and serum insulin but a lower blood sugar than diabetic control rats. Biochemical assays indicated lower AST/SGOT, ALT/SGPT, BUN, and triglycerides but higher HDL in the SDO groups. Immunohistochemistry showed that SDOs reduced damaged islet cells, increased beta-cell size, and improved insulin levels while decreasing alpha cell size and glucagon. The vascular effects of SDOs were like those of normal control treatment and insulin treatment in diabetic rats. SDOs, a yellow silk protein, show potential for long-term diabetes care. [ABSTRACT FROM AUTHOR] more...
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- 2024
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43. 降血糖巧克力的制备及其 3D 打印成型工艺优化.
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蒲 曦, 何春容, 何林蔚, 林 轩, 周红梅, 夏隆江, 李建惠, 雷家瑜, 何宇新, and 董 芹
- Abstract
Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
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- 2024
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44. Hypoglycemic Effect of Polysaccharides from Physalis alkekengi L. in Type 2 Diabetes Mellitus Mice.
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Zhang, Yun, Wang, Minghao, Li, Peng, Lv, Ge, Yao, Jing, and Zhao, Lin
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TYPE 2 diabetes , *OXIDANT status , *HIGH density lipoproteins , *LOW density lipoproteins , *BLOOD sugar , *INSULIN - Abstract
Simple Summary: Type 2 diabetes mellitus is harmful to patients. At present, the main treatment for type 2 diabetes mellitus is to control blood glucose by taking chemical synthesized drugs. However, taking drugs chronically will increase the risk of side effects. Therefore, this study uses polysaccharides extracted from natural plant Physalis alkekengi L. to conduct animal experiments and research whether it can alleviate the related symptoms of type 2 diabetes mellitus in mice and improve the health level of mice, so as to obtain a natural active ingredient that can assist or, to some extent, replace drugs to treat type 2 diabetes mellitus. Type 2 diabetes mellitus (T2DM) is a common metabolic disease that adversely impacts patient health. In this study, a T2DM model was established in ICR mice through the administration of a high-sugar and high-fat diet combined with the intraperitoneal injection of streptozotocin to explore the hypoglycemic effect of polysaccharides from Physalis alkekengi L. After six weeks of treatment, the mice in the high-dosage group (800 mg/kg bw) displayed significant improvements in terms of fasting blood glucose concentration, glucose tolerance, serum insulin level, insulin resistance, and weight loss (p < 0.05). The polysaccharides also significantly regulated blood lipid levels by reducing the serum contents of total triglycerides, total cholesterol, and low-density lipoproteins and increasing the serum content of high-density lipoproteins (p < 0.05). Furthermore, they significantly enhanced the hepatic and pancreatic antioxidant capacities, as determined by measuring the catalase and superoxide dismutase activities and the total antioxidant capacity (p < 0.05). The results of immunohistochemistry showed that the P. alkekengi polysaccharides can increase the expression of GPR43 in mice colon epithelial cells, thereby promoting the secretion of glucagon-like peptide-1. In summary, P. alkekengi polysaccharides can help to regulate blood glucose levels in T2DM mice and alleviate the decline in the antioxidant capacities of the liver and pancreas, thus protecting these organs from damage. [ABSTRACT FROM AUTHOR] more...
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- 2024
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45. Momordica charantia Bioactive Components: Hypoglycemic and Hypolipidemic Benefits Through Gut Health Modulation.
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Xiao, Xiang, Huang, Shiting, Yang, Zihan, Zhu, Ying, Zhu, Lin, Zhao, Yansheng, Bai, Juan, and Kim, Kee-Hong
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ORGANIC compound analysis , *HYPERGLYCEMIA prevention , *PLANT anatomy , *MELONS , *HYPERLIPIDEMIA , *DIGESTION , *ANTILIPEMIC agents , *GUT microbiome , *TASTE , *BIOCHEMISTRY , *CELLULAR signal transduction , *PHYTOCHEMICALS , *HYPOGLYCEMIC agents , *PLANT extracts , *POLYSACCHARIDES , *PEPTIDES , *MOLECULAR structure , *GLYCOSIDES , *ORGANIC compounds , *MOLECULAR biology , *POLYPHENOLS , *CELL receptors , *DIETARY supplements - Abstract
Momordica charantia (MC), a member of the Cucurbitaceae family, is well known for its pharmacological activities that exhibit hypoglycemic and hypolipidemic properties. These properties are largely because of its abundant bioactive compounds and phytochemicals. Over the years, numerous studies have confirmed the regulatory effects of MC extract on glycolipid metabolism. However, there is a lack of comprehensive reviews on newly discovered MC-related components, such as insulin receptor-binding protein-19, adMc1, and MC protein-30 and triterpenoids 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al, and the role of MC in gut microbiota and bitter taste receptors. This review offers an up-to-date overview of the recently reported chemical compositions of MC, including polysaccharides, saponins, polyphenolics, peptides, and their beneficial effects. It also provides the latest updates on the role of MC in the regulation of gut microbiota and bitter taste receptor signaling pathways. As a result, this review will serve as a theoretical basis for potential applications in the creation or modification of MC-based nutrient supplements. [ABSTRACT FROM AUTHOR] more...
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- 2024
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46. Hypoglycemic and hypolipidemic effects of Lippia origanoides Kunth in diabetic rats.
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Miranda, Vinicius Carvalho, Pereira, Yago Luis Gonçalves, da Paz, Allane Patricia Santos, de Souza, Keyla Rodrigues, da Silva, Márcia Cristina Freitas, Muto, Nilton Akio, Monteiro, Patrick Romano, Santos, Agenor Valadares, Hamoy, Moises, de Medeiros, Maria das Graças Freire, do Carmo, Iolanda Souza, Silva, Maria Eduarda Moraes, de Sousa Lima Neto, José, and de Mello, Vanessa Jóia more...
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LIPPIA (Genus) , *ALANINE aminotransferase , *RATS , *HYPERGLYCEMIA , *ASPARTATE aminotransferase , *MEDICINAL plants , *FLAVONOID glycosides , *INSULIN - Abstract
Diabetes mellitus is a metabolic disorder commonly associated with atherosclerosis. Plants with therapeutic potential, such as Lippia origanoides Kunth, emerge as effective alternatives for treating these diseases. Therefore, this work aims to analyze the antihyperglycemic and antidyslipidemic potential of the hydroalcoholic extract of Lippia origanoides Kunth (ELo) in alloxan‐diabetic rats. Animals were treated orally: normal control, hyperglycemic control, positive control glibenclamide (5 mg/kg), and groups treated with ELo (75, 150, and 250 mg/kg). Preclinical evaluation of ELo showed hypoglycemic, hypolipidemic, hepatic, and renal protective effects. At all doses, ELo significantly reduced hyperglycemia, triglycerides, total cholesterol, low‐density lipoprotein, atherogenic index, atherogenic coefficient, and cardiovascular risk index (p <.05). Elo at different doses promoted an increase in insulin release compared to untreated animals (p <.05) and showed α‐glucosidase inhibitory activity (p <.05). Also, ELo (250 mg/kg group) showed maximum reduction of hyperglycemia, alanine transaminase, aspartate aminotransferase, malonaldehyde, and urea compared to the hyperglycemic and glibenclamide groups, and creatinine only compared to the hyperglycemic groups (p <.05). The promising action of ELo in the context of diabetes may be related to the synergistic action of flavonoid compounds identified in liquid chromatography, whose pharmacological capabilities have already been documented in previous studies. The mechanisms may be the stimulation of insulin release; the inhibitory activity of α‐glucosidase; improving general clinical conditions; and the antioxidant effects of the extract. These findings pave the way for the future development of an herbal presentation of L. origanoides Kunth as a hypoglycemic and cardiovascular protector with a lipid‐lowering effect. [ABSTRACT FROM AUTHOR] more...
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- 2024
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47. Optimization of the conditions for microwave-assisted hot-water extraction of polysaccharides from Cordyceps militaris and analysis of their hypoglycemic activity.
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Ni, Zaizhong, Li, Jinting, Qian, Xinyi, Yong, Yidan, Zhang, Peng, Geng, Ying, Wang, Yanan, Chen, Anhui, and Shao, Ying
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LIPID metabolism disorders ,INSULIN sensitivity ,RESPONSE surfaces (Statistics) ,BLOOD sugar ,POLYSACCHARIDES ,INSULIN - Abstract
Cordyceps militaris is recognized for its health benefits in humans. In this study, we optimized the conditions required for microwave-assisted hot-water extraction of polysaccharides isolated from Cordyceps militaris (CM-P) using response surface methodology. The hypoglycemic effects of CM-P were evaluated in vitro and in vivo. The results showed that the optimal extraction conditions for CM-P were a microwave power of 430 W, a microwave time of 5 min, a solid–liquid ratio of 1:44, and three extractions. Under these conditions, we achieved an extraction rate for CM-P of 9.73% ± 0.16%. Within a concentration range of 1.0–10.0 mg/mL, the α-amylase and α-glucosidase inhibition rates of CM-P reached 63.82% ± 1.78% and 60.81% ± 0.94%, respectively, demonstrating the potent hypoglycemic activity of CM-P in vitro. In diabetic mice, CM-P treatment reduced blood glucose and insulin levels and improved insulin sensitivity and glucose tolerance in a dose-dependent manner. CM-P intervention also ameliorated lipid metabolism disorders and alleviated oxidative stress and inflammation. Histological analysis indicated that CM-P improved the organ index of the liver and kidney and reversed pancreatic, adipose, liver, and aortic injuries caused by diabetes. This study demonstrates that CM-P exhibits remarkable hypoglycemic effects and provides a theoretical basis for the development and utilization of polysaccharides from Cordyceps militaris. [ABSTRACT FROM AUTHOR] more...
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- 2024
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48. Functional Properties, Rheological Characteristics, Simulated Digestion, and Fermentation by Human Fecal Microbiota of Polysaccharide from Morchella importuna.
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Shurong Wang, Dongjie Li, Guangle Li, Naixin Duan, Chang He, Junlong Meng, Yanfen Cheng, Xueran Geng, Ludan Hou, Mingchang Chang, and Lijing Xu
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Morchella importuna polysaccharide (MIP) has been proven to have obvious hypoglycemic effects on mice with type 2 diabetes (T2DM). This study looked at the functional and rheological characteristics of MIP, and investigated the effects of MIP on the human fecal microbiota through in vitro fermentation experiments. The outcomes demonstrate the excellent oil-holding capacity, emulsifying, foaming, and rheological characteristics of MIP. After salivary gastrointestinal digestion, the Mw of MIP decreased from 398.2 kDa and 21.5 kDa to 21.9 kDa and 11.7 kDa. By 16S rRNA sequencing of bacteria fermented in vitro, it was found that MIP did not improve the richness and diversity of intestinal microorganisms, but it may exert an anti-T2DM function by significantly increasing the relative abundance of Firmicutes and promoting Ruminococcaceae_UCG_014, Bacteroides, and Blautia proliferation. Escherichia-Shigella could also be inhibited to improve the intestinal microenvironment. In addition, the fermentation of MIP increased the total short-chain fatty acid (SCFA) concentration from 3.23 mmol/L to 39.12 mmol/L, and the propionic acid content increased significantly. In summary, MIP has excellent processing performance and is expected to exert potential anti-T2DM activity through the human intestinal microbiota, which has broad market prospects. [ABSTRACT FROM AUTHOR] more...
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- 2024
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49. 青梅蛹蟲草發酵酒的品質分析及保健效果研究.
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鄭太極, 沈袁媛, 王保忠, 朱海亮, 趙衛民, 張瑩, and 王忠長
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FRUIT wines ,COPPER ,BLOOD lipids ,COLORECTAL cancer ,BLOOD sugar ,WINE flavor & odor - Abstract
Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
- Published
- 2024
- Full Text
- View/download PDF
50. Hypoglycemic Effects of Ginseng α-Amylase Inhibitory Peptides.
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YANG Wen, ZOU Jiaqi, LIU Shengnan, LIU Shiwei, XUE Tingfang, MENG Xingjian, YU Lei, ZHAN Xiaofeng, and BI Yunfeng
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GINSENG ,TYPE 2 diabetes ,AMYLASES ,PEPTIDES ,WEIGHT loss ,BLOOD sugar - Abstract
Mouse models of type 2 diabetes mellitus (T2DM) were constructed using a high-sugar and high-fat diet combined with an intraperitoneal injection of streptozotocin (STZ). After successful modeling, T2DM mice were treated with drugs for four consecutive weeks. The body weight, organ index, blood glucose level, blood lipid level, hepatic oxidative stress response, and pathology test results of the liver were used as reference indicators to investigate the hypoglycemic effects of ginseng α-amylase inhibitory peptides on T2DM mice. The results showed that the acarbose positive group and the ginseng α-amylase inhibitory peptide groups (regardless of the dose) exhibited improvement and regulatory effects of different degrees in the body weight loss and hyperglycemia in mice. Furthermore, the effects were more obvious as the dose increased. Therefore, it was concluded that ginseng α-amylase inhibitory peptides have hypoglycemic effects on T2DM mice at all doses tested. After four weeks of treatment, the blood glucose level in the high-dose group decreased from 15.43 mmol/L right after modeling to 12.10 mmol/L. Similarly, the level in the acarbose-positive group declined from 15.71 mmol/L after modeling to 10.17 mmol/L. In addition, liver injury in both groups was less severe, indicating that a high dose of ginseng α-amylase inhibitory peptides could provide significant protection against T2DM-induced liver injury (P<0.01). Hence, ginseng α-amylase inhibitory peptides were confirmed to have hypoglycemic effects proving their potential as dietary supplements or supplementary products for the treatment of T2DM. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
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