Author: "Hyouei Kawai" - Searchworks@Jio Institute Digital Library Search Results

Author: Hyouei Kawai, Yuichiro Sato, Ken‐ichiro Awasaguchi, Yozo Todo, Kazuya Hayashi, Hiroko Tominaga, and Hiromi Hayashi
Subjects: chemistry.chemical_classification, Potassium carbonate, chemistry.chemical_compound, Oxoquinolines, Ketone, chemistry, One pot reaction, Aryl, Organic Chemistry, Synthon, Chemical synthesis, Aldehyde, Combinatorial chemistry
Abstract: We have achieved the synthesis of 1-aryl-2-substituted 4-oxoquinoline and 4-oxo-1,8-naphthyridine derivatives, which cannot be synthesized by known methods, via two useful synthons, 2-formyl-4-oxoquinoline and 2-methylsulfonyl-4-oxo-1,8-naphthyridine. We also succeeded in the synthesis of 1-aryl-3-fluoro-4-oxoquinoline by fluorocyclization of N-arylenaminone with Select-fluor ® and potassium carbonate in DMF in a one-pot procedure. To the best of our knowledge, this is the first synthesis of 3-fluoro-4-oxoquinoline derivatives. We confirmed that these protocols were mutually applicable to the synthesis of 4-oxoquinoline and 4-oxo-1,8-naphthyridine derivatives.
Published: 2012
Full Text: View/download PDF

Author: Hiroshi Furukawa, Yoshitsugu Arai, Yukio Masaki, Akichika Itoh, Tomoyasu Yamada, and Hyouei Kawai
Subjects: chemistry.chemical_classification, Solvent free, Aqueous solution, chemistry, Organic Chemistry, Diels alder, Organic chemistry, Aza-Diels–Alder reaction, Polymer, Electron, Recyclable catalyst, Catalysis
Abstract: A polymer-supported π-acid (poly-DCKA-1) was found to be a highly efficient and recyclable catalyst in two- and three-component inverse-electron-demand aza-Diels-Alder reactions at room temperature not only in water but also under solvent-free conditions.
Published: 2006
Full Text: View/download PDF

Author: Yuichiro Sato, Hiromi Hayashi, Kazuya Hayashi, Ken‐ichiro Awasaguchi, Hiroko Tominaga, Yozo Todo, and Hyouei Kawai
Subjects: chemistry.chemical_compound, Oxoquinolines, Chemistry, Aryl, Organic chemistry, General Medicine, Combinatorial chemistry
Abstract: Various 2-substituted 4-oxoquinoline and 4-oxo-1,8-naphthyridine derivatives are prepared from the key intermediates (I) and (VIII), respectively.
Published: 2012
Full Text: View/download PDF

Author: Yukio Masaki, Akichika Itoh, Tomoyasu Yamada, Kouichi Yamazaki, Yoshitsugu Arai, Hiroshi Furukawa, and Hyouei Kawai
Subjects: Solvent, chemistry.chemical_compound, Chemistry, Polymer chemistry, Acetal, Copolymer, General Medicine, Ethyleneglycol dimethacrylate, Recyclable catalyst, Catalysis
Abstract: Polymer-supported dicyanoketene acetal (poly-DCKA-1), synthesized by copolymerization of a DCKA bearing a 4-vinylbenzyl group with ethyleneglycol dimethacrylate, was found to be an excellent recyclable catalyst for the three-component Mannich-type reaction of aldehydes, aromatic amines, and TMS enolate of ethyl isobutyrate in water as the sole solvent.
Published: 2006
Full Text: View/download PDF

Author: Hiroshi Furukawa, Yukio Masaki, Kouichi Yamazaki, Akichika Itoh, Tomoyasu Yamada, Yoshitsugu Arai, and Hyouei Kawai
Subjects: Polymers, Chemistry, Organic, Methacrylate, Catalysis, Styrene, Mannich Bases, chemistry.chemical_compound, Acetals, Isobutyrates, Drug Discovery, Nitriles, Copolymer, Organic chemistry, Amines, chemistry.chemical_classification, Aldehydes, Acetal, Water, General Chemistry, General Medicine, Polymer, Organic Chemistry Phenomena, Solvent, Butyrates, chemistry, Models, Chemical, Methacrylates, Ethyleneglycol dimethacrylate
Abstract: Polymer-supported dicyanoketene acetal (poly-DCKA-1), synthesized by copolymerization of a DCKA bearing a 4-vinylbenzyl group with ethyleneglycol dimethacrylate, was found to be an excellent recyclable catalyst for the three-component Mannich-type reaction of aldehydes, aromatic amines, and TMS enolate of ethyl isobutyrate in water as the sole solvent.
Published: 2006

Searchworks