Search

A strategy was established to minimize the stochastic effects of internal and external exposure to radioactive substances by wearing respiratory protection equipment (RPE) during an emergency evacuation. During the evacuation of residents in the event of a nuclear power plant accident, the stochastic effects of internal exposure caused by the inhalation of radioactive aerosol and external exposure due to accumulated radioactive particles in the filter medium of a mask must be minimized. The radioactivity concentration along an evacuation route considers atmospheric dispersion and the resuspension of particles deposited on surfaces. The effective dose due to internal exposure is evaluated using inhalation dose coefficients for each particle diameter. When the face seal leakage and filter medium penetration ratio for each particle diameter of the RPE (N95) is taken into consideration, the internal dose is reduced by 97.2%. Furthermore, the accumulated radioactivity in the filter medium decreases by 91.4% when the respirator is replaced every 48 h.

In this study, Monte Carlo simulations were used to calculate the full-energy peak efficiency of a p-type coaxial high-purity germanium (HPGe) detector. The HPGe detector was modeled using MCNP6 and Geant4, and the thickness of the dead layer of germanium crystals was estimated for an accurate simulation. The dead layer was divided into front and side components, where a point source and a Marinelli beaker source were used to estimate each dead layer thickness. The model was validated by comparing the simulated as well as experimental results for the standard sources of cylindrical and Marinelli beakers. The Geant4 results and experimental results matched up to 4% in the 59.54-1836.05 keV energy range, while MCNP6 matched up to 6% when adjusted for coincidence summing effects. HPGe detector modeled in Monte Carlo simulations can be utilized for experimental validation and experimental setup prior to using actual HPGe detectors.

Curcumin (CUR) has been used in the treatment of various diseases such as cough, fever, skin disease, and infection because of various biological benefits such as anti-inflammatory, antiviral, antibacterial, and antitumor activity. However, CUR is a BCS class 4 group and has a limitation of low bioavailability due to low solubility and permeability. Therefore, the purpose of this study is to prepare a nanosuspension (NSP) loaded with CUR (CUR-NSP) using a statistical design approach to improve the oral bioavailability of CUR, and then to develop CUR-NSP coated with tannic acid to increase the mucoadhesion in the GI tract. Firstly, the optimized CUR-NSP, composed of sodium dodecyl sulfate (SDS) and polyvinylpyrrolidone/vinyl acetate (PVP/VA), was modified with tannic acid (TA). The particle size and polydispersity index of the formulation measured by laser scattering analyzer were 127.7 ± 1.3 nm and 0.227 ± 0.010, respectively. In addition, the precipitation in distilled water (DW) was 1.52 ± 0.58%. Using a differential scanning calorimeter and X-ray diffraction analysis, the stable amorphous form of CUR was confirmed in the formulation, and it was confirmed that CUR-NSP formulation was coated with TA through a Fourier transform-infrared spectroscopy. In the mucoadhesion assay using the turbidity, it was confirmed that TA-CUR-NSP had higher affinity for mucus than CUR-NSP under all pH conditions. This means that the absorption of CUR can be improved by increasing the retention time in the GI tract of the formulation. In addition, the drug release profile showed more than 80% release, and in the cellular uptake study, the absorption of the formulation (TA-CUR-NSP) containing TA acting as an inhibitor of P-gp was increased by 1.6-fold. In the evaluation of antioxidant activity, the SOD activity of TA-CUR-NSP was remarkably high due to TA, which improves cellular uptake and has antioxidant activity. In the pharmacokinetic evaluation, the maximum drug plasma concentration of the TA-coated NSP formulation was 7.2-fold higher than that of the pure drug. In all experiments, it was confirmed that the TA-CUR-NSP is a promising approach to overcome the low oral bioavailability of CUR.

Metformin has several problems such as low bioavailability, short half-life, and narrow absorption window, sustained and site-specific drug delivery system is required. Floating drug delivery systems are very useful to achieve these purposes. However, conventional floating systems have several limitations; lag time, a high proportion of excipient in the tablet, using non-biocompatible excipient, and requirement of a complicated procedure. To overcome these obstacles, we developed a hollow-core floating tablet (HCFT). The HCFT immediately floated in pH 1.2, 4.0, 6.8 medium, and even distilled water. The floating duration time of HCFT was24 h. From the in vitro release study, it was confirmed that HCFT showed the sustain release profile of metformin for 12 h. Water uptake and matrix erosion were evaluated for predicting the buoyancy and drug release kinetics of HCFT in the body. Factor analysis was applied to optimize the formulation. There were significant (p 0.05) differences in metformin plasma concentration of 4 h and 6 h between two groups. Compared with Glucophage® XR, the relative bioavailability of metformin HCFT was 123.81 ± 3.52%. The X-ray imaging of optimized formulation revealed that HCFT was constantly floating in the stomach region of the rabbit, thereby indicating improved gastric retention for6 h. Consequently, all the findings indicate that HCFT could be an effective gastric retention system and applied extensively to other drugs with narrow absorption windows.

This paper describes an experimental setup developed to measure the beta-ray energy spectrum as well as a Geant4 simulation study conducted to characterize the properties of a beta-spectrometer. The beta-spectrometer comprises a multi-wire chamber to generate signals to indicate the incidence of beta rays and a plastic scintillation detector to measure its energy. The coincidence method of the detector signals was used to remove high gamma-ray interference. To evaluate the performance of the developed spectrometer, the energy spectra were measured with the radionuclide sources ( 137Cs and 207Bi) emitting internal conversion electrons and gamma rays. The gamma-ray interference removal rate of the spectrometer using the coincidence method was 99.12 ± 0.09%. To reconstruct the beta spectrum from the measured spectrum, Monte Carlo simulations using the Geant4 toolkit were performed to calculate the coefficient related to the effect of gamma rays. The obtained spectrum confirmed that the energy resolution and intrinsic internal conversion peak detection efficiency of the beta-spectrometer were 10.2% at 1 MeV and 91.6%, respectively.

A simple, sensitive, and rapid UHPLC-MS/MS method was developed for the simultaneous determination of veratraldehyde and its metabolite veratric acid in rat plasma. Cinnamaldehyde was used as an internal standard (IS) and the one-step protein precipitation method with 0.2% formic acid in acetonitrile (mobile phase B) was used for the sample extraction. Reversed C18 column (YMC-Triart C18 column, 50 mm &times, 2.0 mm, 1.9 &micro, m) was used for chromatographic separation and was maintained at 30 &deg, C. The total run time was 4.5 min and the electrospray ionization in positive mode was used with the transition m/z 167.07 &rarr, 139.00 for veratraldehyde, m/z 183.07 &rarr, 139.00 for veratric acid, and m/z 133.00 &rarr, 55.00 for IS. The developed method exhibited good linearity (r2&thinsp, &ge, &thinsp, 0.9977), and the lower limits of quantification ranged from 3 to 10 ng/mL for the two analytes. Intra-day precision and accuracy parameters met the criteria (within &plusmn, 15%) during the validation. The bioanalytical method was applied for the determination of veratraldehyde and veratric acid in rat plasma after oral and percutaneous administration of 300 and 600 mg/kg veratraldehyde. Using the analytical methods established in this study, we can confirm the absorption and metabolism of veratraldehyde in rats for various routes.

Docetaxel (DTX) has clinical efficacy in the treatment of breast cancer, but it is difficult to develop a product for oral administration, due to low solubility and permeability. This study focused on preparing a self-microemulsifying drug delivery system (SME) loaded with DTX-phospholipid complex (DTX@PLC), to improve the dissolution and gastrointestinal (GI) permeability of DTX. A dual technique combining the phospholipid complexation and SME formulation described as improving upon the disadvantages of DTX has been proposed. We hypothesized that the complexation of DTX with phospholipids can improve the lipophilicity of DTX, thereby increasing the affinity of the drug to the cell lipid membrane, and simultaneously improving permeability through the GI barrier. Meanwhile, DTX@PLC-loaded SME (DTX@PLC-SME) increases the dissolution and surface area of DTX by forming a microemulsion in the intestinal fluid, providing sufficient opportunity for the drug to contact the GI membrane. First, we prepared DTX@PLC-SME by combining dual technologies, which are advantages for oral absorption. Next, we optimized DTX@PLC-SME with nanosized droplets (117.1 nm), low precipitation (8.9%), and high solubility (33.0 mg/g), which formed a homogeneous microemulsion in the aqueous phase. Dissolution and cellular uptake studies demonstrated that DTX@PLC-SME showed 5.6-fold higher dissolution and 2.3-fold higher DTX uptake in Caco-2 cells than raw material. In addition, an ex vivo gut sac study confirmed that DTX@PLC-SME improved GI permeability of DTX by 2.6-fold compared to raw material. These results suggested that DTX@PLC-SME can significantly overcome the disadvantages of anticancer agents, such as low solubility and permeability.

In this paper, we looked around the application of the lens distortion correction and 3D posture correction algorithm which is preferentially to be performed for three dimensional information extraction and visibility of the object material using stereo camera. Regarding the part of lens distortion correction, distortion due to the spherical aberration of the lens was corrected by obtaining the pattern image of each camera and calculating k 1 , k 2 , p 1 , p 2 . It could be confirmed that more stereoscopic perception output of an image is possible through convergence control according to the distance of the object material.

In this paper, the in-orbit receiving environment of a GPS receiver for low/medium altitude satellites is studied and in particular, antenna characteristics of the GPS receiver for various antenna beam directions are examined. In addition, we propose a method to reduce error in calculating the position by reducing the geometric dilution of precision (GDOP). By computer simulations, the relation between the number of visible GPS satellites and GDOP is investigated and the fact that there must exist the most possible GPS satellites in order to reduce GDOP is also confirmed. Besides, since the error factor can be reduced if GDOP becomes smaller can yield the better performance of the GPS receiver. Another simulation result indicates that the heading angle of the GPS receiver antenna must be changed in proportion to the altitude of the receiver in order to obtain better receiving characteristics. The wider receiving range of the antenna can prevent from the situation that the direction of the satellite body must be changed. In this paper, even though we analyze the characteristics for GPS receivers with high inclination angle by computer simulations, we can also characterize the characteristics for GPS receivers with arbitrary inclination angle by considering the earth is a nearly sphere and GPS satellites are uniformly distributed.

In this paper, an SOTDMA algorithm which is a core technique of AIS was developed ahead of developing AIS which is suggested as a measure to solve the problem of frequent ship collision accident at sea and a performance estimation simulator based on the AIS technology recommendation, was also developed to examine the algorithm in the environment which is similar to the reality. And the verification on the algorithm and the simulator was conducted by the international standard.