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5. Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma

Author

Won Kim, Se, Lee, Seung-Eun, Lyun Oh, Young, Kim, Seokhwi, Hee Park, Sun, and Hyeon Kim, Jae

Abstract

Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient’s serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.

Published
2016
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6. Effect of structured individualized education on continuous glucose monitoring use in poorly controlled patients with type 1 diabetes: A randomized controlled trial.

Author

Yoo, Jee Hee, Kim, Gyuri, Lee, Hyun Jung, Sim, Kang Hee, Jin, Sang-Man, Kim, Jae Hyeon, Hee Yoo, Jee, Jung Lee, Hyun, Hee Sim, Kang, and Hyeon Kim, Jae

Subjects
*TYPE 1 diabetes, *INSULIN pumps, *INDIVIDUALIZED instruction, *RANDOMIZED controlled trials, *GROUP extensions (Mathematics), *GLUCOSE
Abstract

Aim: We aimed to evaluate the efficacy of structured individualized education combined with real-time continuous glucose monitoring (rt-CGM) on glycemic outcomes in adults with type 1 diabetes.Methods: This was a single-center, 3-month, randomized controlled trial of 47 adults with type 1 diabetes with HbA1c ≥ 7.0% (53 mmol/mol). Study participants were assigned randomly (1:1) to a structured education group or control group. The control group received the same education as the intervention group in a 3-month extension study. The primary outcome was the mean difference in time in range (TIR 70-180 mg/dL [3.9-10.0 mmol/L]) between groups.Results: TIR was higher for the education group than the control group (63.4% vs. 44.5%), resulting in a between-group difference of 15.3% (95% CI 7.9 to 22.8, p < 0.001) at week 12. HbA1c decreased 0.5% (5.5 mmol/mol) more in the intervention group than the control group at week 12 (-0.1 to -1.0, p < 0.001). In the extension period, TIR increased significantly (8.9% [2.2 to 15.6], p = 0.01) in educated control group.Conclusions: In adults with type 1 diabetes, rt-CGM use with individualized education resulted in better TIR than rt-CGM alone, highlighting the importance of personalized structured education when using rt-CGM. (ClinicalTrials.gov, number NCT03794934). [ABSTRACT FROM AUTHOR]

Published
2022
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