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Background: College health education professionals need a comprehensive understanding of student health outcomes to promote health for all students. Purpose: To examine health-related outcomes by gender identity in a national sample of college students. Methods: Participants (n = 85,912) completed the National College Health Assessment IIc during the 2017-18 academic year. Forty-seven outcomes were compared between cisgender (CG; n = 83,425), transgender (TG; n = 1,439), and non-binary, non-transgender (NBNT; n = 1,048) students using separate logistic regression models and adjusting for age, race and relationship status. Results: There was a significant difference between groups for most outcomes, with TG and NBNT being more likely than CG to experience unhealthy outcomes. A similar pattern emerged for 31 of the variables, with TG and NBNT being significantly different from CG but not significantly different from each other. The greatest differences were found in the areas of drug use and mental/emotional health. Discussion: The results of this study indicate important differences in health outcomes by gender identity among college students. Translation to Health Education Practice: It is critical that health education professionals consider the unique experiences of TG and NBNT students when developing comprehensive interventions to improve their overall health status.

Doxorubicin (DOX) is associated with cardiac dysfunction and irreversible testicular damage. Androgen deprivation therapy (ADT) is administered prior to DOX treatment to preserve testicular function. However, ADT may exacerbate DOXinduced cardiac dysfunction. Exercise is cardioprotective, but the effects of exercise on cardiac function during combined ADT and DOX treatment are currently unknown. In this study, male Sprague-Dawley rats were randomly assigned to experimental groups: control (CON), ADT, DOX, or ADT+DOX. Animals received ADT or control implants on days 1 and 29 of the 56-day protocol. Animals remained sedentary (SED) or engaged in treadmill endurance exercise (TM) beginning on day 1. On day 15, the animals received DOX at 1 mg-(kg body mass)-1-d-1 by intraperitoneal injection for 10 consecutive days, or an equivalent volume of saline. On day 57, cardiac function was assessed in vivo and ex vivo. Animals treated with DOX alone, or with combined ADT+DOX, showed significant (P < 0.05) reductions in left ventricular developed pressure (-21% and -27%), maximal rate of pressure development (-29% and -32%), and maximal rate of pressure decline (25% and 31%), respectively when compared with the sedentary control animals. Endurance exercise training attenuated (P > 0.05) cardiac dysfunction associated with combined ADT+DOX treatment, indicating that exercise during simultaneous ADT+DOX treatment is cardioprotective. Key words: androgen deprivation therapy, cardiotoxicity, doxorubicin, endurance training, exercise, heart. La doxorubicine (DOX) est associee a la dysfonction cardiaque et a un dommage testiculaire irreversible. Une therapie de privation d'androgene (TPA) est administree prealablement au traitement a la DOX afin de preserver la fonction testiculaire. Cependant, la TPA peut exacerber la dysfonction cardiaque induite par la DOX. L'exercice est cardioprotecteur, mais les effets de l'exercice sur la fonction cardiaque durant le traitement combine TPA et DOX sont actuellement inconnus. Dans cette etude, des rats Sprague-Dawley ont ete repartis au hasard dans les groupes experimentaux designes : controle (CON), TPA, DOX ou TPA+DOX. Les animaux ont recu une TPA ou des implants controles aux jours 1 a 29 des 56 jours du protocole. Les animaux sont demeures sedentaires (SED) ou ont ete soumis a un exercice d'endurance sur tapis roulant (TR) commencant au jour 1. Au jour 15, les animaux ont recu de la DOX a 1 mg x [(kg de masse corporelle).sup.-1] x [jour.sup.-1], i.p., pendant 10 jours consecutifs, ou un volume equivalent de saline. Au jour 57, la fonction cardiaque a ete evaluee in vivo et ex vivo. Les animaux traites a la DOX seule de meme que ceux soumis au traitement TPA+DOX presentaient des reductions significatives (P 0,05) la dysfonction cardiaque associee au traitement TPA+DOX, indiquant que l'exercice lors d'un traitement simultane TPA+DOX est cardioprotecteur. [Traduit par la Redaction] Mots-cles: therapie de privation d'androgene, cardiotoxicite, doxorubicine, entrainement d'endurance, exercice, coeur., Introduction Anthracyclines have proven to be some of the most effective antineoplastic agents in the treatment of cancer. Doxorubicin (DOX), also known as Adriamycin, is one of the most widely [...]

Byline: Karen Y. Wonders, PhD (Department of Health, Physical Education, and Recreation, Wright State University, Dayton, Ohio); David S. Hydock, PhD (School of Sport and Exercise Science and the Rocky [...]

Reducing testosterone and estrogen levels with a luteinizing hormone-releasing hormone agonist such as Zoladex (i.e., chemical gonadectomy) is a common treatment for many prostate and breast cancer patients, respectively. There are reports of surgical gonadectomy inducing cardiac dysfunction, and exercise has been shown to be cardioprotective under these circumstances. Minimal research has been done investigating the effects of chemical gonadectomy and increased physical activity on cardiac function. The purpose of this investigation was to examine the effects of chemical gonadectomy and physical activity on cardiac function. Male (M) and female (F) Sprague-Dawley rats received either Zoladex treatment (Zol) that suppressed gonadal function for 8 wk or control implants (Con) and either were allowed unlimited access to voluntary running wheels (WR) or remained sedentary (Sed) throughout the treatment period. In vivo and ex vivo left ventricle (LV) function were then assessed, and myosin heavy chain (MHC) expression was analyzed to help explain LV functional differences. Hearts from M Sed+Zol exhibited significantly lower aortic blood flow velocity, developed pressure, and maximal rate of pressure development and higher [beta]-MHC expression than M Sed+Con. Hearts from F Sed+Zol exhibited significantly lower LV wall thicknesses, fractional shortening, and developed pressure and higher [beta]-MHC expression than F Sed+Con. This cardiac dysfunction was not evident in hearts from M or F WR+Zol, and this was associated with a preservation of the MHC isoform distribution. Thus an 8-wk chemical gonadectomy with Zoladex promoted cardiac dysfunction in male and female rats, and voluntary wheel running protected against this cardiac dysfunction. echocardiography; myosin heavy chain; orchiectomy; ovariectomy; sex hormones