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3 results on '"Hyandavi Balla"'

1. Expression of heat shock protein 70 in oral epithelial dysplasia and oral squamous cell carcinoma: An immunohistochemical study

Author

K P Priyanka, Sumit Majumdar, Sreekanth Kotina, Divya Uppala, and Hyandavi Balla

Subjects
heat shock proteins 70, immunohistochemistry, oral cancer, tumor node and metastasis staging, Dentistry, RK1-715
Abstract

Introduction: Heat shock proteins are biomarkers regulating the degree of differention and aggressiveness in oral carcinogenesis. The study was carried out to evaluate the expression of HSP 70 in histological grades of epithelial dysplasia and oral squamous cell carcinoma using immunohistochemistry. Methodology: A sample of 40, which included 10 (Normal), 15 (epithelial dysplasia) and 15 (oral squamous cell carcinoma) were selected. The biopsy samples were stained using H and E staining and HSP 70 IHC. Results: There was a statistical significant difference in expression of HSP 70 between normal oral mucosal tissue, leukoplakia and OSCC. Discussion and Conclusion: This study concludes the critical role of HSP70 as an oncogene in the development of oral cancer. HSP70 inhibition is, therefore a promising therapeutic approach for cancer treatment.

Published
2019
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2. Evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma

Author

Divya Uppala, Hyandavi Balla, Sravya Kodati, Sreekanth Kotina, Madhurya Namana, and Sumit Majumdar

Subjects
Pathology, medicine.medical_specialty, business.industry, medicine.medical_treatment, H&E stain, Neck dissection, lymph node, medicine.disease, Primary tumor, Pathology and Forensic Medicine, Metastasis, oral squamous cell carcinoma, medicine.anatomical_structure, Otorhinolaryngology, Cervical lymph nodes, medicine, Immunomorphological patterns, metastasis, Original Article, tumor node metastasis staging, Lymph, Stage (cooking), business, General Dentistry, Lymph node
Abstract

Background: The Immunomorphological patterns of Lymph Nodes indirectly assess the host immune response facing a malignant tumor. These patterns also help us predict the susceptibility of the patient to Lymph Node Metastasis. Aims and Objectives: To evaluate the Immunomorphological patterns of Lymph Nodes in Oral Squamous Cell Carcinoma and to correlate them with the histopathological subtype of Oral Squamous Cell Carcinoma, TNM staging and the degree of tumor involvement within the Lymph Nodes. Methodology: A total of 40 subjects were taken for the study. Individuals who were clinically and histopathologically diagnosed as cases of Squamous Cell Carcinoma, who had undergone Radical or Elective Neck dissection were considered. The excised Lymph Nodes along with the primary tumor were collected stained with Hematoxylin and Eosin. The Lymph Nodes were assessed for Metastasis and Immunomorphological patterns. Statistical Correlation was done between the Immunomorphological pattern of Lymph Nodes and (a) Size of the tumor, (b) TNM stage of the tumor, (c) Histopathological Grade of the primary tumor, (d) Metastasis of the Lymph Node and (e) Grade of the Metastasis of Lymph Node. Statistical Correlation was done between the Metastasis of the Lymph Node and (a) Size of the tumor and (b) TNM stage of the tumor. Results and Conclusion: Statistically, a significant association was observed between TNM staging and Immunomorphological patterns of Lymph Node (P < 0.01). The relationship between histopathological grade of primary tumor of Squamous Cell Carcinoma and the Immunomorphological patterns was statistically significant (P < 0.01). Statistically, a significant association was observed between Sinus Histiocytosis pattern and decreased occurrence of nodal metastasis (P < 0.01).

Published
2020

3. Ameloblastic fibrosarcoma of mandible–A case report

Author

Sumit Majumdar, Hyandavi Balla, Divya Uppala, and Siva Kalyan Utharavalli

Subjects
Ameloblastic Fibrosarcoma, Posterior mandible, Pathology, medicine.medical_specialty, business.industry, Ectomesenchyme, Mandible, 030206 dentistry, medicine.disease, Pathology and Forensic Medicine, Odontogenic, 03 medical and health sciences, Ameloblastic fibroma, 0302 clinical medicine, Otorhinolaryngology, Male patient, 030220 oncology & carcinogenesis, Medicine, Surgery, Sarcoma, Oral Surgery, business
Abstract

Ameloblastic fibrosarcoma (AFS) is considered as a rare malignant neoplasm composed of benign, odontogenic ameloblastomatous epithelium and malignant ectomesenchyme. It predominantly occurs in the posterior mandible with age ranging from 3 to 83 years. Pain and swelling are the most commonly associated clinical symptoms. The purpose of this report is to present a case of 16-year-old male patient who presented with an extra oral swelling in posterior mandible region which was later proven histopathologically as AFS.

Published
2017

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