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Point-based image editing enables accurate and flexible control through content dragging. However, the role of text embedding in the editing process has not been thoroughly investigated. A significant aspect that remains unexplored is the interaction between text and image embeddings. In this study, we show that during the progressive editing of an input image in a diffusion model, the text embedding remains constant. As the image embedding increasingly diverges from its initial state, the discrepancy between the image and text embeddings presents a significant challenge. Moreover, we found that the text prompt significantly influences the dragging process, particularly in maintaining content integrity and achieving the desired manipulation. To utilize these insights, we propose DragText, which optimizes text embedding in conjunction with the dragging process to pair with the modified image embedding. Simultaneously, we regularize the text optimization process to preserve the integrity of the original text prompt. Our approach can be seamlessly integrated with existing diffusion-based drag methods with only a few lines of code., Comment: 22 pages, 18 figures

Reducing scan time in Positron Emission Tomography (PET) imaging while maintaining high-quality images is crucial for minimizing patient discomfort and radiation exposure. Due to the limited size of datasets and distribution discrepancy across scanners in medical imaging, fine-tuning in a parameter-efficient and effective manner is on the rise. Motivated by the potential of Parameter-Efficient Fine-Tuning (PEFT), we aim to address these issues by effectively leveraging PEFT to improve limited data and GPU resource issues in multi-scanner setups. In this paper, we introduce PETITE, Parameter-Efficient Fine-Tuning for MultI-scanner PET to PET REconstruction that uses fewer than 1% of the parameters. To the best of our knowledge, this study is the first to systematically explore the efficacy of diverse PEFT techniques in medical imaging reconstruction tasks via prevalent encoder-decoder-type deep models. This investigation, in particular, brings intriguing insights into PETITE as we show further improvements by treating encoder and decoder separately and mixing different PEFT methods, namely, Mix-PEFT. Using multi-scanner PET datasets comprised of five different scanners, we extensively test the cross-scanner PET scan time reduction performances (i.e., a model pre-trained on one scanner is fine-tuned on a different scanner) of 21 feasible Mix-PEFT combinations to derive optimal PETITE. We show that training with less than 1% parameters using PETITE performs on par with full fine-tuning (i.e., 100% parameter)

In neuroimaging, generally, brain CT is more cost-effective and accessible imaging option compared to MRI. Nevertheless, CT exhibits inferior soft-tissue contrast and higher noise levels, yielding less precise structural clarity. In response, leveraging more readily available CT to construct its counterpart MRI, namely, medical image-to-image translation (I2I), serves as a promising solution. Particularly, while diffusion models (DMs) have recently risen as a powerhouse, they also come with a few practical caveats for medical I2I. First, DMs' inherent stochasticity from random noise sampling cannot guarantee consistent MRI generation that faithfully reflects its CT. Second, for 3D volumetric images which are prevalent in medical imaging, naively using 2D DMs leads to slice inconsistency, e.g., abnormal structural and brightness changes. While 3D DMs do exist, significant training costs and data dependency bring hesitation. As a solution, we propose novel style key conditioning (SKC) and inter-slice trajectory alignment (ISTA) sampling for the 2D Brownian bridge diffusion model. Specifically, SKC ensures a consistent imaging style (e.g., contrast) across slices, and ISTA interconnects the independent sampling of each slice, deterministically achieving style and shape consistent 3D CT-to-MRI translation. To the best of our knowledge, this study is the first to achieve high-quality 3D medical I2I based only on a 2D DM with no extra architectural models. Our experimental results show superior 3D medical I2I than existing 2D and 3D baselines, using in-house CT-MRI dataset and BraTS2023 FLAIR-T1 MRI dataset., Comment: 13 pages, 7 figures, Early accepted at Medical Image Computing and Computer Assisted Intervention (MICCAI) 2024

Image dehazing, addressing atmospheric interference like fog and haze, remains a pervasive challenge crucial for robust vision applications such as surveillance and remote sensing under adverse visibility. While various methodologies have evolved from early works predicting transmission matrix and atmospheric light features to deep learning and dehazing networks, they innately prioritize dehazing quality metrics, neglecting the need for real-time applicability in time-sensitive domains like autonomous driving. This work introduces FALCON (Frequency Adjoint Link with CONtinuous density mask), a single-image dehazing system achieving state-of-the-art performance on both quality and speed. Particularly, we develop a novel bottleneck module, namely, Frequency Adjoint Link, operating in the frequency space to globally expand the receptive field with minimal growth in network size. Further, we leverage the underlying haze distribution based on the atmospheric scattering model via a Continuous Density Mask (CDM) which serves as a continuous-valued mask input prior and a differentiable auxiliary loss. Comprehensive experiments involving multiple state-of-the-art methods and ablation analysis demonstrate FALCON's exceptional performance in both dehazing quality and speed (i.e., >$180 frames-per-second), quantified by metrics such as FPS, PSNR, and SSIM.

Significant methodological strides have been made toward Chest X-ray (CXR) understanding via modern vision-language models (VLMs), demonstrating impressive Visual Question Answering (VQA) and CXR report generation abilities. However, existing CXR understanding frameworks still possess several procedural caveats. (1) Previous methods solely use CXR reports, which are insufficient for comprehensive Visual Question Answering (VQA), especially when additional health-related data like medication history and prior diagnoses are needed. (2) Previous methods use raw CXR reports, which are often arbitrarily structured. While modern language models can understand various text formats, restructuring reports for clearer, organized anatomy-based information could enhance their usefulness. (3) Current evaluation methods for CXR-VQA primarily emphasize linguistic correctness, lacking the capability to offer nuanced assessments of the generated answers. In this work, to address the aforementioned caveats, we introduce WoLF, a Wide-scope Large Language Model Framework for CXR understanding. To resolve (1), we capture multi-faceted records of patients, which are utilized for accurate diagnoses in real-world clinical scenarios. Specifically, we adopt the Electronic Health Records (EHR) to generate instruction-following data suited for CXR understanding. Regarding (2), we enhance report generation performance by decoupling knowledge in CXR reports based on anatomical structure even within the attention step via masked attention. To address (3), we introduce an AI-evaluation protocol optimized for assessing the capabilities of LLM. Through extensive experimental validations, WoLF demonstrates superior performance over other models on MIMIC-CXR in the AI-evaluation arena about VQA (up to +9.47%p mean score) and by metrics about report generation (+7.3%p BLEU-1)., Comment: 11 pages main paper, 2 pages supplementary

Recent advances in text-conditioned image generation diffusion models have begun paving the way for new opportunities in modern medical domain, in particular, generating Chest X-rays (CXRs) from diagnostic reports. Nonetheless, to further drive the diffusion models to generate CXRs that faithfully reflect the complexity and diversity of real data, it has become evident that a nontrivial learning approach is needed. In light of this, we propose CXRL, a framework motivated by the potential of reinforcement learning (RL). Specifically, we integrate a policy gradient RL approach with well-designed multiple distinctive CXR-domain specific reward models. This approach guides the diffusion denoising trajectory, achieving precise CXR posture and pathological details. Here, considering the complex medical image environment, we present "RL with Comparative Feedback" (RLCF) for the reward mechanism, a human-like comparative evaluation that is known to be more effective and reliable in complex scenarios compared to direct evaluation. Our CXRL framework includes jointly optimizing learnable adaptive condition embeddings (ACE) and the image generator, enabling the model to produce more accurate and higher perceptual CXR quality. Our extensive evaluation of the MIMIC-CXR-JPG dataset demonstrates the effectiveness of our RL-based tuning approach. Consequently, our CXRL generates pathologically realistic CXRs, establishing a new standard for generating CXRs with high fidelity to real-world clinical scenarios.

Semantic segmentation has innately relied on extensive pixel-level annotated data, leading to the emergence of unsupervised methodologies. Among them, leveraging self-supervised Vision Transformers for unsupervised semantic segmentation (USS) has been making steady progress with expressive deep features. Yet, for semantically segmenting images with complex objects, a predominant challenge remains: the lack of explicit object-level semantic encoding in patch-level features. This technical limitation often leads to inadequate segmentation of complex objects with diverse structures. To address this gap, we present a novel approach, EAGLE, which emphasizes object-centric representation learning for unsupervised semantic segmentation. Specifically, we introduce EiCue, a spectral technique providing semantic and structural cues through an eigenbasis derived from the semantic similarity matrix of deep image features and color affinity from an image. Further, by incorporating our object-centric contrastive loss with EiCue, we guide our model to learn object-level representations with intra- and inter-image object-feature consistency, thereby enhancing semantic accuracy. Extensive experiments on COCO-Stuff, Cityscapes, and Potsdam-3 datasets demonstrate the state-of-the-art USS results of EAGLE with accurate and consistent semantic segmentation across complex scenes.

Leveraging semantically precise pseudo masks derived from image-level class knowledge for segmentation, namely image-level Weakly Supervised Semantic Segmentation (WSSS), still remains challenging. While Class Activation Maps (CAMs) using CNNs have steadily been contributing to the success of WSSS, the resulting activation maps often narrowly focus on class-specific parts (e.g., only face of human). On the other hand, recent works based on vision transformers (ViT) have shown promising results based on their self-attention mechanism to capture the semantic parts but fail in capturing complete class-specific details (e.g., entire body parts of human but also with a dog nearby). In this work, we propose Complementary Branch (CoBra), a novel dual branch framework consisting of two distinct architectures which provide valuable complementary knowledge of class (from CNN) and semantic (from ViT) to each branch. In particular, we learn Class-Aware Projection (CAP) for the CNN branch and Semantic-Aware Projection (SAP) for the ViT branch to explicitly fuse their complementary knowledge and facilitate a new type of extra patch-level supervision. Our model, through CoBra, fuses CNN and ViT's complementary outputs to create robust pseudo masks that integrate both class and semantic information effectively. Extensive experiments qualitatively and quantitatively investigate how CNN and ViT complement each other on the PASCAL VOC 2012 dataset, showing a state-of-the-art WSSS result. This includes not only the masks generated by our model, but also the segmentation results derived from utilizing these masks as pseudo labels.

Transfer learning has been widely utilized to mitigate the data scarcity problem in the field of Alzheimer's disease (AD). Conventional transfer learning relies on re-using models trained on AD-irrelevant tasks such as natural image classification. However, it often leads to negative transfer due to the discrepancy between the non-medical source and target medical domains. To address this, we present evidence-empowered transfer learning for AD diagnosis. Unlike conventional approaches, we leverage an AD-relevant auxiliary task, namely morphological change prediction, without requiring additional MRI data. In this auxiliary task, the diagnosis model learns the evidential and transferable knowledge from morphological features in MRI scans. Experimental results demonstrate that our framework is not only effective in improving detection performance regardless of model capacity, but also more data-efficient and faithful., Comment: Accepted to IEEE International Symposium on Biomedical Imaging (ISBI) 2023. The authorship was changed from co-first authors to a single first author, which was authorized by the adviser/corresponding author Jinyoung Yeo (Apr 18th, 2023)

Multiclass neural networks are a common tool in modern unsupervised domain adaptation, yet an appropriate theoretical description for their non-uniform sample complexity is lacking in the adaptation literature. To fill this gap, we propose the first PAC-Bayesian adaptation bounds for multiclass learners. We facilitate practical use of our bounds by also proposing the first approximation techniques for the multiclass distribution divergences we consider. For divergences dependent on a Gibbs predictor, we propose additional PAC-Bayesian adaptation bounds which remove the need for inefficient Monte-Carlo estimation. Empirically, we test the efficacy of our proposed approximation techniques as well as some novel design-concepts which we include in our bounds. Finally, we apply our bounds to analyze a common adaptation algorithm that uses neural networks.

The topic of generalizing machine learning models learned on a collection of source domains to unknown target domains is challenging. While many domain generalization (DG) methods have achieved promising results, they primarily rely on the source domains at train-time without manipulating the target domains at test-time. Thus, it is still possible that those methods can overfit to source domains and perform poorly on target domains. Driven by the observation that domains are strongly related to styles, we argue that reducing the gap between source and target styles can boost models' generalizability. To solve the dilemma of having no access to the target domain during training, we introduce Test-time Fourier Style Calibration (TF-Cal) for calibrating the target domain style on the fly during testing. To access styles, we utilize Fourier transformation to decompose features into amplitude (style) features and phase (semantic) features. Furthermore, we present an effective technique to Augment Amplitude Features (AAF) to complement TF-Cal. Extensive experiments on several popular DG benchmarks and a segmentation dataset for medical images demonstrate that our method outperforms state-of-the-art methods., Comment: 31st International Joint Conference on Artificial Intelligence (IJCAI) 2022

Discourse analysis allows us to attain inferences of a text document that extend beyond the sentence-level. The current performance of discourse models is very low on texts outside of the training distribution's coverage, diminishing the practical utility of existing models. There is need for a measure that can inform us to what extent our model generalizes from the training to the test sample when these samples may be drawn from distinct distributions. While this can be estimated via distribution shift, we argue that this does not directly correlate with change in the observed error of a classifier (i.e. error-gap). Thus, we propose to use a statistic from the theoretical domain adaptation literature which can be directly tied to error-gap. We study the bias of this statistic as an estimator of error-gap both theoretically and through a large-scale empirical study of over 2400 experiments on 6 discourse datasets from domains including, but not limited to: news, biomedical texts, TED talks, Reddit posts, and fiction. Our results not only motivate our proposal and help us to understand its limitations, but also provide insight on the properties of discourse models and datasets which improve performance in domain adaptation. For instance, we find that non-news datasets are slightly easier to transfer to than news datasets when the training and test sets are very different. Our code and an associated Python package are available to allow practitioners to make more informed model and dataset choices.

Despite the extensive usage of point clouds in 3D vision, relatively limited data are available for training deep neural networks. Although data augmentation is a standard approach to compensate for the scarcity of data, it has been less explored in the point cloud literature. In this paper, we propose a simple and effective augmentation method called PointWOLF for point cloud augmentation. The proposed method produces smoothly varying non-rigid deformations by locally weighted transformations centered at multiple anchor points. The smooth deformations allow diverse and realistic augmentations. Furthermore, in order to minimize the manual efforts to search the optimal hyperparameters for augmentation, we present AugTune, which generates augmented samples of desired difficulties producing targeted confidence scores. Our experiments show our framework consistently improves the performance for both shape classification and part segmentation tasks. Particularly, with PointNet++, PointWOLF achieves the state-of-the-art 89.7 accuracy on shape classification with the real-world ScanObjectNN dataset., Comment: 9 pages, Accepted to ICCV 2021

Application of deep neural networks to medical imaging tasks has in some sense become commonplace. Still, a "thorn in the side" of the deep learning movement is the argument that deep networks are prone to overfitting and are thus unable to generalize well when datasets are small (as is common in medical imaging tasks). One way to bolster confidence is to provide mathematical guarantees, or bounds, on network performance after training which explicitly quantify the possibility of overfitting. In this work, we explore recent advances using the PAC-Bayesian framework to provide bounds on generalization error for large (stochastic) networks. While previous efforts focus on classification in larger natural image datasets (e.g., MNIST and CIFAR-10), we apply these techniques to both classification and segmentation in a smaller medical imagining dataset: the ISIC 2018 challenge set. We observe the resultant bounds are competitive compared to a simpler baseline, while also being more explainable and alleviating the need for holdout sets., Comment: MICCAI 2021

We consider a model-agnostic solution to the problem of Multi-Domain Learning (MDL) for multi-modal applications. Many existing MDL techniques are model-dependent solutions which explicitly require nontrivial architectural changes to construct domain-specific modules. Thus, properly applying these MDL techniques for new problems with well-established models, e.g. U-Net for semantic segmentation, may demand various low-level implementation efforts. In this paper, given emerging multi-modal data (e.g., various structural neuroimaging modalities), we aim to enable MDL purely algorithmically so that widely used neural networks can trivially achieve MDL in a model-independent manner. To this end, we consider a weighted loss function and extend it to an effective procedure by employing techniques from the recently active area of learning-to-learn (meta-learning). Specifically, we take inner-loop gradient steps to dynamically estimate posterior distributions over the hyperparameters of our loss function. Thus, our method is model-agnostic, requiring no additional model parameters and no network architecture changes; instead, only a few efficient algorithmic modifications are needed to improve performance in MDL. We demonstrate our solution to a fitting problem in medical imaging, specifically, in the automatic segmentation of white matter hyperintensity (WMH). We look at two neuroimaging modalities (T1-MR and FLAIR) with complementary information fitting for our problem., Comment: IEEE International Symposium on Biomedical Imaging 2021

Typical machine learning frameworks heavily rely on an underlying assumption that training and test data follow the same distribution. In medical imaging which increasingly begun acquiring datasets from multiple sites or scanners, this identical distribution assumption often fails to hold due to systematic variability induced by site or scanner dependent factors. Therefore, we cannot simply expect a model trained on a given dataset to consistently work well, or generalize, on a dataset from another distribution. In this work, we address this problem, investigating the application of machine learning models to unseen medical imaging data. Specifically, we consider the challenging case of Domain Generalization (DG) where we train a model without any knowledge about the testing distribution. That is, we train on samples from a set of distributions (sources) and test on samples from a new, unseen distribution (target). We focus on the task of white matter hyperintensity (WMH) prediction using the multi-site WMH Segmentation Challenge dataset and our local in-house dataset. We identify how two mechanically distinct DG approaches, namely domain adversarial learning and mix-up, have theoretical synergy. Then, we show drastic improvements of WMH prediction on an unseen target domain., Comment: IEEE International Symposium on Biomedical Imaging 2021

Theoretically, domain adaptation is a well-researched problem. Further, this theory has been well-used in practice. In particular, we note the bound on target error given by Ben-David et al. (2010) and the well-known domain-aligning algorithm based on this work using Domain Adversarial Neural Networks (DANN) presented by Ganin and Lempitsky (2015). Recently, multiple variants of DANN have been proposed for the related problem of domain generalization, but without much discussion of the original motivating bound. In this paper, we investigate the validity of DANN in domain generalization from this perspective. We investigate conditions under which application of DANN makes sense and further consider DANN as a dynamic process during training. Our investigation suggests that the application of DANN to domain generalization may not be as straightforward as it seems. To address this, we design an algorithmic extension to DANN in the domain generalization case. Our experimentation validates both theory and algorithm.

Tremendous recent literature show that associations between different brain regions, i.e., brain connectivity, provide early symptoms of neurological disorders. Despite significant efforts made for graph neural network (GNN) techniques, their focus on graph nodes makes the state-of-the-art GNN methods not suitable for classifying brain connectivity as graphs where the objective is to characterize disease-relevant network dysfunction patterns on graph links. To address this issue, we propose Multi-resolution Edge Network (MENET) to detect disease-specific connectomic benchmarks with high discrimination power across diagnostic categories. The core of MENET is a novel graph edge-wise transform that we propose, which allows us to capture multi-resolution ``connectomic'' features. Using a rich set of the connectomic features, we devise a graph learning framework to jointly select discriminative edges and assign diagnostic labels for graphs. Experiments on two real datasets show that MENET accurately predicts diagnostic labels and identify brain connectivities highly associated with neurological disorders such as Alzheimer's Disease and Attention-Deficit/Hyperactivity Disorder.

Generative models using neural network have opened a door to large-scale studies for various application domains, especially for studies that suffer from lack of real samples to obtain statistically robust inference. Typically, these generative models would train on existing data to learn the underlying distribution of the measurements (e.g., images) in latent spaces conditioned on covariates (e.g., image labels), and generate independent samples that are identically distributed in the latent space. Such models may work for cross-sectional studies, however, they are not suitable to generate data for longitudinal studies that focus on "progressive" behavior in a sequence of data. In practice, this is a quite common case in various neuroimaging studies whose goal is to characterize a trajectory of pathologies of a specific disease even from early stages. This may be too ambitious especially when the sample size is small (e.g., up to a few hundreds). Motivated from the setup above, we seek to develop a conditional generative model for longitudinal data generation by designing an invertable neural network. Inspired by recurrent nature of longitudinal data, we propose a novel neural network that incorporates recurrent subnetwork and context gating to include smooth transition in a sequence of generated data. Our model is validated on a video sequence dataset and a longitudinal AD dataset with various experimental settings for qualitative and quantitative evaluations of the generated samples. The results with the AD dataset captures AD specific group differences with sufficiently generated longitudinal samples that are consistent with existing literature, which implies a great potential to be applicable to other disease studies.

There has recently been a concerted effort to derive mechanisms in vision and machine learning systems to offer uncertainty estimates of the predictions they make. Clearly, there are enormous benefits to a system that is not only accurate but also has a sense for when it is not sure. Existing proposals center around Bayesian interpretations of modern deep architectures -- these are effective but can often be computationally demanding. We show how classical ideas in the literature on exponential families on probabilistic networks provide an excellent starting point to derive uncertainty estimates in Gated Recurrent Units (GRU). Our proposal directly quantifies uncertainty deterministically, without the need for costly sampling-based estimation. We demonstrate how our model can be used to quantitatively and qualitatively measure uncertainty in unsupervised image sequence prediction. To our knowledge, this is the first result describing sampling-free uncertainty estimation for powerful sequential models such as GRUs., Comment: Version 2