14 results on '"Hwang, K-R."'
Search Results
2. Association of the interferon-γ gene (CA)n repeat polymorphism with endometriosis
- Author
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Kim, J J, Choi, Y M, Hwang, S S, Yoon, S H, Lee, G H, Chae, S J, Hwang, K R, and Moon, S Y
- Published
- 2011
- Full Text
- View/download PDF
3. Polycystic ovary syndrome with hyperandrogenism as a risk factor for non-obese non-alcoholic fatty liver disease
- Author
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Kim, J. J., primary, Kim, D., additional, Yim, J. Y., additional, Kang, J. H., additional, Han, K. H., additional, Kim, S. M., additional, Hwang, K. R., additional, Ku, S. Y., additional, Suh, C. S., additional, Kim, S. H., additional, and Choi, Y. M., additional
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- 2017
- Full Text
- View/download PDF
4. Development of Foldable Micro Eletric Vehicle
- Author
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Hwang, K. R. and Suh, I. S.
- Abstract
se vedhæftet fil
- Published
- 2012
5. Association study of anti-Mullerian hormone and anti-Mullerian hormone type II receptor polymorphisms with idiopathic primary ovarian insufficiency
- Author
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Yoon, S. H., primary, Choi, Y. M., additional, Hong, M. A., additional, Kim, J. J., additional, Lee, G. H., additional, Hwang, K. R., additional, and Moon, S. Y., additional
- Published
- 2013
- Full Text
- View/download PDF
6. Reproductive endocrinology
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Nazzaro, A., primary, Salerno, A., additional, Di Iorio, L., additional, Landino, G., additional, Marino, S., additional, Pastore, E., additional, Fabregues, F., additional, Iraola, A., additional, Casals, G., additional, Creus, M., additional, Peralta, S., additional, Penarrubia, J., additional, Manau, D., additional, Civico, S., additional, Balasch, J., additional, Lindgren, I., additional, Giwercman, Y. L., additional, Celik, E., additional, Turkcuoglu, I., additional, Ata, B., additional, Karaer, A., additional, Kirici, P., additional, Berker, B., additional, Park, J., additional, Kim, J., additional, Rhee, J., additional, Krishnan, M., additional, Rustamov, O., additional, Russel, R., additional, Fitzgerald, C., additional, Roberts, S., additional, Hapuarachi, S., additional, Tan, B. K., additional, Mathur, R. S., additional, van de Vijver, A., additional, Blockeel, C., additional, Camus, M., additional, Polyzos, N., additional, Van Landuyt, L., additional, Tournaye, H., additional, Turhan, N. O., additional, Hizli, D., additional, Kamalak, Z., additional, Kosus, A., additional, Kosus, N., additional, Kafali, H., additional, Lukaszuk, A., additional, Kunicki, M., additional, Liss, J., additional, Bednarowska, A., additional, Jakiel, G., additional, Lukaszuk, K., additional, Lukaszuk, M., additional, Olszak-Sokolowska, B., additional, Wasniewski, T., additional, Neuberg, M., additional, Cavalcanti, V., additional, Peluso, C., additional, Lechado, B. L., additional, Cordts, E. B., additional, Christofolini, D. M., additional, Barbosa, C. P., additional, Bianco, B., additional, Venetis, C. A., additional, Kolibianakis, E. M., additional, Bosdou, J., additional, Tarlatzis, B. C., additional, Onal, M., additional, Gungor, D. N., additional, Acet, M., additional, Kahraman, S., additional, Kuijper, E., additional, Twisk, J., additional, Caanen, M., additional, Korsen, T., additional, Hompes, P., additional, Kushnir, M., additional, Rockwood, A., additional, Meikle, W., additional, Lambalk, C. B., additional, Yan, X., additional, Dai, X., additional, Wang, J., additional, Zhao, N., additional, Cui, Y., additional, Liu, J., additional, Yarde, F., additional, Maas, A. H. E. M., additional, Franx, A., additional, Eijkemans, M. J. C., additional, Drost, J. T., additional, van Rijn, B. B., additional, van Eyck, J., additional, van der Schouw, Y. T., additional, Broekmans, F. J. M., additional, Martyn, F., additional, Anglim, B., additional, Wingfield, M., additional, Fang, T., additional, Yan, G. J., additional, Sun, H. X., additional, Hu, Y. L., additional, Chrudimska, J., additional, Krenkova, P., additional, Macek, M., additional, Teixeira da Silva, J., additional, Cunha, M., additional, Silva, J., additional, Viana, P., additional, Goncalves, A., additional, Barros, N., additional, Oliveira, C., additional, Sousa, M., additional, Barros, A., additional, Nelson, S. M., additional, Lloyd, S. M., additional, McConnachie, A., additional, Khader, A., additional, Fleming, R., additional, Lawlor, D. A., additional, Thuesen, L., additional, Andersen, A. N., additional, Loft, A., additional, Smitz, J., additional, Abdel-Rahman, M., additional, Ismail, S., additional, Silk, J., additional, Abdellah, M., additional, Abdellah, A. H., additional, Ruiz, F., additional, Cruz, M., additional, Piro, M., additional, Collado, D., additional, Garcia-Velasco, J. A., additional, Requena, A., additional, Kollmann, Z., additional, Bersinger, N. A., additional, McKinnon, B., additional, Schneider, S., additional, Mueller, M. D., additional, von Wolff, M., additional, Vaucher, A., additional, Weiss, B., additional, Stute, P., additional, Marti, U., additional, Chai, J., additional, Yeung, W. Y. T., additional, Lee, C. Y. V., additional, Li, W. H. R., additional, Ho, P. C., additional, Ng, H. Y. E., additional, Kim, S. M., additional, Kim, S. H., additional, Jee, B. C., additional, Ku, S., additional, Suh, C. S., additional, Choi, Y. M., additional, Kim, J. G., additional, Moon, S. Y., additional, Lee, J. H., additional, Kim, S. G., additional, Kim, Y. Y., additional, Kim, H. J., additional, Lee, K. H., additional, Park, I. H., additional, Sun, H. G., additional, Hwang, Y. I., additional, Sung, N. Y., additional, Choi, M. H., additional, Cha, S. H., additional, Park, C. W., additional, Kim, J. Y., additional, Yang, K. M., additional, Song, I. O., additional, Koong, M. K., additional, Kang, I. S., additional, Kim, H. O., additional, Haines, C., additional, Wong, W. Y., additional, Kong, W. S., additional, Cheung, L. P., additional, Choy, T. K., additional, Leung, P. C., additional, Fadini, R., additional, Coticchio, G., additional, Renzini, M. M., additional, Guglielmo, M. C., additional, Brambillasca, F., additional, Hourvitz, A., additional, Albertini, D. F., additional, Novara, P., additional, Merola, M., additional, Dal Canto, M., additional, Iza, J. A. A., additional, DePablo, J. L., additional, Anarte, C., additional, Domingo, A., additional, Abanto, E., additional, Barrenetxea, G., additional, Kato, R., additional, Kawachiya, S., additional, Bodri, D., additional, Kondo, M., additional, Matsumoto, T., additional, Maldonado, L. G. L., additional, Setti, A. S., additional, Braga, D. P. A. F., additional, Iaconelli, A., additional, Borges, E., additional, Iaconelli, C., additional, Figueira, R. C. S., additional, Kitaya, K., additional, Taguchi, S., additional, Funabiki, M., additional, Tada, Y., additional, Hayashi, T., additional, Nakamura, Y., additional, Snajderova, M., additional, Zemkova, D., additional, Lanska, V., additional, Teslik, L., additional, Calonge, R. N. -, additional, Ortega, L., additional, Garcia, A., additional, Cortes, S., additional, Guijarro, A., additional, Peregrin, P. C., additional, Bellavia, M., additional, Pesant, M. H., additional, Wirthner, D., additional, Portman, L., additional, de Ziegler, D., additional, Wunder, D., additional, Chen, X., additional, Chen, S. H. L., additional, Liu, Y. D., additional, Tao, T., additional, Xu, L. J., additional, Tian, X. L., additional, Ye, D. S. H., additional, He, Y. X., additional, Carby, A., additional, Barsoum, E., additional, El-Shawarby, S., additional, Trew, G., additional, Lavery, S., additional, Mishieva, N., additional, Barkalina, N., additional, Korneeva, I., additional, Ivanets, T., additional, Abubakirov, A., additional, Chavoshinejad, R., additional, Hartshorne, G. m., additional, Marei, W., additional, Fouladi-nashta, A. a., additional, Kyrkou, G., additional, Trakakis, E., additional, Chrelias, C. H., additional, Alexiou, E., additional, Lykeridou, K., additional, Mastorakos, G., additional, Bersinger, N., additional, Ferrero, H., additional, Gomez, R., additional, Garcia-Pascual, C. M., additional, Simon, C., additional, Pellicer, A., additional, Turienzo, A., additional, Lledo, B., additional, Guerrero, J., additional, Ortiz, J. A., additional, Morales, R., additional, Ten, J., additional, Llacer, J., additional, Bernabeu, R., additional, De Leo, V., additional, Focarelli, R., additional, Capaldo, A., additional, Stendardi, A., additional, Gambera, L., additional, Marca, A. L., additional, Piomboni, P., additional, Kim, J. J., additional, Kang, J. H., additional, Hwang, K. R., additional, Chae, S. J., additional, Yoon, S. H., additional, Ku, S. Y., additional, Iliodromiti, S., additional, Kelsey, T. W., additional, Anderson, R. A., additional, Lee, H. J., additional, Weghofer, A., additional, Kushnir, V. A., additional, Shohat-Tal, A., additional, Lazzaroni, E., additional, Barad, D. H., additional, Gleicher, N. N., additional, Shavit, T., additional, Shalom-Paz, E., additional, Fainaru, O., additional, Michaeli, M., additional, Kartchovsky, E., additional, Ellenbogen, A., additional, Gerris, J., additional, Vandekerckhove, F., additional, Delvigne, A., additional, Dhont, N., additional, Madoc, B., additional, Neyskens, J., additional, Buyle, M., additional, Vansteenkiste, E., additional, De Schepper, E., additional, Pil, L., additional, Van Keirsbilck, N., additional, Verpoest, W., additional, Debacquer, D., additional, Annemans, L., additional, De Sutter, P., additional, Von Wolff, M., additional, Bersinger, N. a., additional, Verit, F. F., additional, Keskin, S., additional, Sargin, A. K., additional, Karahuseyinoglu, S., additional, Yucel, O., additional, Yalcinkaya, S., additional, Comninos, A. N., additional, Jayasena, C. N., additional, Nijher, G. M. K., additional, Abbara, A., additional, De Silva, A., additional, Veldhuis, J. D., additional, Ratnasabapathy, R., additional, Izzi-Engbeaya, C., additional, Lim, A., additional, Patel, D. A., additional, Ghatei, M. A., additional, Bloom, S. R., additional, Dhillo, W. S., additional, Colodron, M., additional, Guillen, J. J., additional, Garcia, D., additional, Coll, O., additional, Vassena, R., additional, Vernaeve, V., additional, Pazoki, H., additional, Bolouri, G., additional, Farokhi, F., additional, Azarbayjani, M. A., additional, Alebic, M. S., additional, Stojanovic, N., additional, Abali, R., additional, Yuksel, A., additional, Aktas, C., additional, Celik, C., additional, Guzel, S., additional, Erfan, G., additional, Sahin, O., additional, Zhongying, H., additional, Shangwei, L., additional, Qianhong, M., additional, Wei, F., additional, Lei, L., additional, Zhun, X., additional, Yan, W., additional, De Baerdemaeker, A., additional, Tilleman, K., additional, Vansteelandt, S., additional, Oliveira, J. B. A., additional, Baruffi, R. L. R., additional, Petersen, C. G., additional, Mauri, A. L., additional, Nascimento, A. M., additional, Vagnini, L., additional, Ricci, J., additional, Cavagna, M., additional, Massaro, F. C., additional, Pontes, A., additional, Franco, J. G., additional, El-khayat, W., additional, Elsadek, M., additional, Foroozanfard, F., additional, Saberi, H., additional, Moravvegi, A., additional, Kazemi, M., additional, Gidoni, Y. S., additional, Raziel, A., additional, Friedler, S., additional, Strassburger, D., additional, Hadari, D., additional, Kasterstein, E., additional, Ben-Ami, I., additional, Komarovsky, D., additional, Maslansky, B., additional, Bern, O., additional, Ron-El, R., additional, Izquierdo, M. P., additional, Araico, F., additional, Somova, O., additional, Feskov, O., additional, Feskova, I., additional, Bezpechnaya, I., additional, Zhylkova, I., additional, Tishchenko, O., additional, Oguic, S. K., additional, Baldani, D. P., additional, Skrgatic, L., additional, Simunic, V., additional, Vrcic, H., additional, Rogic, D., additional, Juras, J., additional, Goldstein, M. S., additional, Garcia De Miguel, L., additional, Campo, M. C., additional, Gurria, A., additional, Alonso, J., additional, Serrano, A., additional, Marban, E., additional, Shalev, L., additional, Yung, Y., additional, Yerushalmi, G., additional, Giovanni, C., additional, Has, J., additional, Maman, E., additional, Monterde, M., additional, Marzal, A., additional, Vega, O., additional, Rubio, J. m., additional, Diaz-Garcia, C., additional, Eapen, A., additional, Datta, A., additional, Kurinchi-selvan, A., additional, Birch, H., additional, Lockwood, G. M., additional, Ornek, M. C., additional, Ates, U., additional, Usta, T., additional, Goksedef, C. P., additional, Bruszczynska, A., additional, Glowacka, J., additional, Jaguszewska, K., additional, Oehninger, S., additional, Nelson, S., additional, Verweij, P., additional, Stegmann, B., additional, Ando, H., additional, Takayanagi, T., additional, Minamoto, H., additional, Suzuki, N., additional, Rubinshtein, N., additional, Saltek, S., additional, Demir, B., additional, Dilbaz, B., additional, Demirtas, C., additional, Kutteh, W., additional, Shapiro, B., additional, Witjes, H., additional, Gordon, K., additional, Lauritsen, M. P., additional, Pinborg, A., additional, Freiesleben, N. L., additional, Mikkelsen, A. L., additional, Bjerge, M. R., additional, Chakraborty, P., additional, Goswami, S. K., additional, Chakravarty, B. N., additional, Mittal, M., additional, Bajoria, R., additional, Narvekar, N., additional, Chatterjee, R., additional, Bentzen, J. G., additional, Johannsen, T. H., additional, Scheike, T., additional, Friis-Hansen, L., additional, Sunkara, S., additional, Coomarasamy, A., additional, Faris, R., additional, Braude, P., additional, Khalaf, Y., additional, Makedos, A., additional, Masouridou, S., additional, Chatzimeletiou, K., additional, Zepiridis, L., additional, Mitsoli, A., additional, Lainas, G., additional, Sfontouris, I., additional, Tzamtzoglou, A., additional, Kyrou, D., additional, Lainas, T., additional, Fermin, A., additional, Crisol, L., additional, Exposito, A., additional, Prieto, B., additional, Mendoza, R., additional, Matorras, R., additional, Louwers, Y., additional, Lao, O., additional, Kayser, M., additional, Palumbo, A., additional, Sanabria, V., additional, Rouleau, J. P., additional, Puopolo, M., additional, Hernandez, M. J., additional, Rubio, J. M., additional, Ozturk, S., additional, Sozen, B., additional, Yaba-Ucar, A., additional, Mutlu, D., additional, Demir, N., additional, Olsson, H., additional, Sandstrom, R., additional, Grundemar, L., additional, Papaleo, E., additional, Corti, L., additional, Rabellotti, E., additional, Vanni, V. S., additional, Potenza, M., additional, Molgora, M., additional, Vigano, P., additional, Candiani, M., additional, Fernandez-Sanchez, M., additional, Bosch, E., additional, Visnova, H., additional, Barri, P., additional, Fauser, B. J. C. M., additional, Arce, J. C., additional, Peluso, P., additional, Trevisan, C. M., additional, Fonseca, F. A., additional, Bakas, P., additional, Vlahos, N., additional, Hassiakos, D., additional, Tzanakaki, D., additional, Gregoriou, O., additional, Liapis, A., additional, Creatsas, G., additional, Adda-Herzog, E., additional, Steffann, J., additional, Sebag-Peyrelevade, S., additional, Poulain, M., additional, Benachi, A., additional, Fanchin, R., additional, Zhang, D., additional, Aybar, F., additional, Temel, S., additional, Hamdine, O., additional, Macklon, N. S., additional, Laven, J. S., additional, Cohlen, B. J., additional, Verhoeff, A., additional, van Dop, P. A., additional, Bernardus, R. E., additional, Oosterhuis, G. J. E., additional, Holleboom, C. A. G., additional, van den Dool-Maasland, G. C., additional, Verburg, H. J., additional, van der Heijden, P. F. M., additional, Blankhart, A., additional, Fauser, B. C. J. M., additional, Broekmans, F. J., additional, Bhattacharya, J., additional, Mitra, A., additional, Dutta, G. B., additional, Kundu, A., additional, Bhattacharya, M., additional, Kundu, S., additional, Pigny, P., additional, Dassonneville, A., additional, Catteau-Jonard, S., additional, Decanter, C., additional, Dewailly, D., additional, Pouly, J., additional, Olivennes, F., additional, Massin, N., additional, Celle, M., additional, Caizergues, N., additional, Gaudoin, M., additional, Messow, M., additional, Vanhove, L., additional, Peigne, M., additional, Thomas, P., additional, and Robin, G., additional
- Published
- 2013
- Full Text
- View/download PDF
7. Atherogenic changes in low-density lipoprotein particle profiles were not observed in non-obese women with polycystic ovary syndrome
- Author
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Kim, J. J., primary, Chae, S. J., additional, Choi, Y. M., additional, Hwang, K. R., additional, Song, S. H., additional, Yoon, S. H., additional, Kim, S. M., additional, Ku, S. Y., additional, Kim, S. H., additional, Kim, J. G., additional, and Moon, S. Y., additional
- Published
- 2013
- Full Text
- View/download PDF
8. Sensitivity verification and application of UHF sensor for partial discharge measurement in high voltage power transformer
- Author
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Jung, J. R., primary, Hwang, K. R., additional, Kim, Y. M., additional, Lyu, E. T., additional, and Yang, H. J., additional
- Published
- 2012
- Full Text
- View/download PDF
9. Assessment of hirsutism among Korean women: results of a randomly selected sample of women seeking pre-employment physical check-up
- Author
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Kim, J. J., primary, Chae, S. J., additional, Choi, Y. M., additional, Hwang, S. S., additional, Hwang, K. R., additional, Kim, S. M., additional, Yoon, S. H., additional, and Moon, S. Y., additional
- Published
- 2010
- Full Text
- View/download PDF
10. Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women
- Author
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Chae, S. J., primary, Kim, J. J., additional, Choi, Y. M., additional, Hwang, K. R., additional, Jee, B. C., additional, Ku, S. Y., additional, Suh, C. S., additional, Kim, S. H., additional, Kim, J. G., additional, and Moon, S. Y., additional
- Published
- 2008
- Full Text
- View/download PDF
11. Association of the interferon-γ gene (CA)n repeat polymorphism with endometriosis.
- Author
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Kim, J. J., Choi, Y. M., Hwang, S. S., Yoon, S. H., Lee, G. H., Chae, S. J., Hwang, K. R., and Moon, S. Y.
- Subjects
ENDOMETRIOSIS ,GENETIC polymorphisms ,GENE frequency ,GENOTYPE-environment interaction ,POLYMERASE chain reaction ,INTERFERONS - Abstract
Objective To investigate whether the interferon-γ (IFN-γ) gene (CA)
n repeat polymorphism is associated with susceptibility to endometriosis.Design Case-control study. Setting University Department of Obstetrics and Gynaecology. Population Women with (n = 622) and without (n = 442) endometriosis. Methods Genotyping was performed by fluorescent polymerasechain reaction (PCR) and gene-scan analysis. Main outcome measures Genotype distribution and allele frequency of the dinucleotide (CA)n repeat polymorphism in the IFN-γ gene. Results Seven alleles (12-18 repeats) of the IFN-γ gene (CA)n repeat polymorphism were found. In both patients with endometriosis and controls the most common allele was composed of 13 repeats, followed by an allele of 15 repeats, and then by an allele of 12 repeats. Patients with endometriosis had a significantly higher incidence of genotypes with alleles composed of fewer repeats (12-13 repeats), compared with the controls (92.0 versus 84.4%, respectively, P < 001). Conclusions Our results suggest that the (CA)n repeat polymorphism in the IFN-γ gene may be associated with a risk of endometriosis in the South Korean population. [ABSTRACT FROM AUTHOR]- Published
- 2011
- Full Text
- View/download PDF
12. Computed tomography and magnetic resonance imaging evaluation in pediatric unilateral sensorineural hearing loss.
- Author
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Lee, B. D., Hwang, K. R., Lee, S. A., Lee, J. D., and Kim, B. G.
- Subjects
- *
CONFERENCES & conventions , *COCHLEAR implants , *SENSORINEURAL hearing loss , *MAGNETIC resonance imaging , *TOMOGRAPHY - Abstract
Objectives: Children with unilateral sensorineural hearing loss (USNHL) are not actively evaluated by physicians. The diagnostic tool for evaluation of USNHL is also controversial, and no strategy for diagnosing USNHL through imaging studies has been established. We examined the results of temporal bone computed tomography (TBCT) imaging and magnetic resonance imaging (MRI) studies on children with USNHL. Subjects and Method: Eighty-nine patients with USNHL were reviewed. Of these patients, 21 underwent both TBCT and MRI, 51 underwent temporal MRI only, and 17 underwent TBCT only. Results: The etiology of USNHL were determined through imaging studies in 20 patients. The most common abnormal finding (65%) was a narrow internal auditory canal identified on TBCT and cochlear nerve aplasia on temporal MRI. Incomplete partition (20%), common cavity (10%), and labyrinthitis ossificans (5%) were also observed in imaging studies. The hearing threshold was lower in USNHL patients with normal findings (76.1±28.7 dB) than in USNHL patients with abnormal findings on TBCT or temporal MRI (100.1±22.3 dB). Conclusions: Cochlear and cochlear nerve abnormalities can be detected through imaging studies in approximately 25% of patients with USNHL. Therefore, we suggest that children should undergo TBCT when USNHL is confirmed through audiologic evaluation. [ABSTRACT FROM AUTHOR]
- Published
- 2018
13. Association of the interferon-γ gene (CA)n repeat polymorphism with endometriosis.
- Author
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Kim JJ, Choi YM, Hwang SS, Yoon SH, Lee GH, Chae SJ, Hwang KR, and Moon SY
- Subjects
- Adult, Case-Control Studies, Female, Genotype, Humans, Polymerase Chain Reaction, Polymorphism, Genetic, Republic of Korea, Endometriosis genetics, Gene Frequency, Genetic Predisposition to Disease, Interferon-gamma genetics, Trinucleotide Repeats genetics
- Abstract
Objective: To investigate whether the interferon-γ (IFN-γ) gene (CA)(n) repeat polymorphism is associated with susceptibility to endometriosis., Design: Case-control study., Setting: University Department of Obstetrics and Gynaecology., Population: Women with (n = 622) and without (n = 442) endometriosis., Methods: Genotyping was performed by fluorescent polymerase chain reaction (PCR) and gene-scan analysis., Main Outcome Measures: Genotype distribution and allele frequency of the dinucleotide (CA)(n) repeat polymorphism in the IFN-γ gene., Results: Seven alleles (12-18 repeats) of the IFN-γ gene (CA)(n) repeat polymorphism were found. In both patients with endometriosis and controls the most common allele was composed of 13 repeats, followed by an allele of 15 repeats, and then by an allele of 12 repeats. Patients with endometriosis had a significantly higher incidence of genotypes with alleles composed of fewer repeats (12-13 repeats), compared with the controls (92.0 versus 84.4%, respectively, P < 001)., Conclusions: Our results suggest that the (CA)(n) repeat polymorphism in the IFN-γ gene may be associated with a risk of endometriosis in the South Korean population., (© 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.)
- Published
- 2011
- Full Text
- View/download PDF
14. Noradrenergic neurotransmission at PVN in locus ceruleus-induced baroreflex suppression in rats.
- Author
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Hwang KR, Chan SH, and Chan JY
- Subjects
- Animals, Extracellular Space metabolism, Glutamic Acid pharmacology, Locus Coeruleus drug effects, Male, Norepinephrine metabolism, Osmolar Concentration, Rats, Rats, Sprague-Dawley, Receptors, Adrenergic, alpha physiology, Time Factors, Baroreflex physiology, Locus Coeruleus physiology, Norepinephrine physiology, Paraventricular Hypothalamic Nucleus physiology, Synaptic Transmission physiology
- Abstract
We investigated the role of ascending noradrenergic projections from the locus ceruleus (LC) to the paraventricular nucleus (PVN) of the hypothalamus in LC-induced suppression of the baroreceptor reflex (BRR) response in adult Sprague-Dawley rats maintained under pentobarbital anesthesia. On the basis of in vivo microdialysis and high-performance liquid chromatography-electrochemical detection, microinjection of L-glutamate (5 nmol) into the LC resulted in a site-specific increase in norepinephrine (NE) concentration in the dialysate collected from the parvocellular subnucleus of the PVN. The temporal course of this increase in extracellular NE concentration in the PVN coincided with the time course of inhibition elicited by the LC on the BRR response. Microinfusion of NE (10, 50, or 100 nM) into the parvocellular subnucleus of the PVN by reverse microdialysis also promoted a parallel increase in NE at the PVN and a reduction in the BRR response. Inhibition of the BRR response induced by microinjection into the PVN of the alpha 1-adrenoceptor agonist phenylephrine (10 nmol) or chemical activation of the LC was reversed by bilateral PVN microinjection of prazosin (100 pmol). However, local application to the PVN of the alpha 2- or beta-adrenoceptor agonist guanabenz (10 nmol) or isoproterenol (10 nmol) was ineffective. Our results suggest that NE released from the LC-PVN noradrenergic projection may participate in LC-induced suppression of the BRR response by activating the alpha 1-adrenoceptors at the parvocellular subnucleus of the PVN.
- Published
- 1998
- Full Text
- View/download PDF
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