175 results on '"Huynh W"'
Search Results
2. FKRP‐related muscular dystrophy responsive to immunotherapy
- Author
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Waller, S., primary, Stockwell, J., additional, Tay, T., additional, Pamphlett, R., additional, Beuzeville, S., additional, and Huynh, W., additional
- Published
- 2024
- Full Text
- View/download PDF
3. Quantitative modeling of gate-tunable cavity exciton-polaritons in transition-metal dichalcogenides.
- Author
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B Iyer, R., Huynh, W., Luan, Y., Shinar, R., Shinar, J., Wang, J., and Fei, Z.
- Subjects
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DISPERSION relations , *POLARITONS , *HIGH voltages , *EXCITON theory , *LEGAL evidence - Abstract
We performed a comprehensive real-space simulation study of propagative exciton-polaritons (EPs) of tungsten disulfide (WS2) inside a Fabry–Pérot cavity. Through our simulations, we were able to construct the dispersion relation and determine the propagation length (Lp) of EPs, both of which show sensitive dependence on the applied gate voltage. We found that Lp increases at higher gate voltages when excited at the exciton energy but shows opposite gate dependence at the trion energy. These observations are direct evidence of the coupling between the cavity mode with excitons and trions of WS2. Furthermore, we demonstrate a proof-of-concept device based on the tunable cavity EPs of WS2, which is promising for application as photonic transistors, modulators, or electrical-to-optical converters. Our work unveils the real-space transport properties of gate-tunable cavity EPs and paves the way for future applications of EPs in nanophotonic devices and circuits. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Pitfalls in the Diagnosis and Management of an Unusual Presentation of Clinically Amyopathic Dermatomyositis: A Case Report Written With the Assistance of ChatGPT
- Author
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Jansz, Jacqueline, primary, Tran, Huynh W, additional, and Sweiss, Nadera J, additional
- Published
- 2023
- Full Text
- View/download PDF
5. Quantitative muscle ultrasound as a biomarker in Charcot-Marie-Tooth neuropathy
- Author
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Shahrizaila, N., Noto, Y., Simon, N.G., Huynh, W., Shibuya, K., Matamala, J.M., Dharmadasa, T., Devenney, E., Kennerson, M.L., Nicholson, G.A., and Kiernan, M.C.
- Published
- 2017
- Full Text
- View/download PDF
6. [18F]FDG-PET/CT in Staphylococcus aureus bacteremia: a systematic review
- Author
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Epi Infectieziekten Team 1, Infection & Immunity, MMB Medische Staf, Buis, D T P, Sieswerda, E, Kouijzer, I J E, Huynh, W Y, Burchell, G L, Berrevoets, M A H, Prins, J M, Sigaloff, K C E, Epi Infectieziekten Team 1, Infection & Immunity, MMB Medische Staf, Buis, D T P, Sieswerda, E, Kouijzer, I J E, Huynh, W Y, Burchell, G L, Berrevoets, M A H, Prins, J M, and Sigaloff, K C E
- Published
- 2022
7. Additional file 3 of [18F]FDG-PET/CT in Staphylococcus aureus bacteremia: a systematic review
- Author
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Buis, D. T. P., Sieswerda, E., Kouijzer, I. J. E., Huynh, W. Y., Burchell, G. L., Berrevoets, M. A. H., Prins, J. M., and Sigaloff, K. C. E.
- Abstract
Additional file 3. Table S1. Diagnostic findings on [18F]FDG-PET/CT per study.
- Published
- 2022
- Full Text
- View/download PDF
8. Additional file 1 of [18F]FDG-PET/CT in Staphylococcus aureus bacteremia: a systematic review
- Author
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Buis, D. T. P., Sieswerda, E., Kouijzer, I. J. E., Huynh, W. Y., Burchell, G. L., Berrevoets, M. A. H., Prins, J. M., and Sigaloff, K. C. E.
- Abstract
Additional file 1. Appendix SA. Search strategy review.
- Published
- 2022
- Full Text
- View/download PDF
9. Additional file 2 of [18F]FDG-PET/CT in Staphylococcus aureus bacteremia: a systematic review
- Author
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Buis, D. T. P., Sieswerda, E., Kouijzer, I. J. E., Huynh, W. Y., Burchell, G. L., Berrevoets, M. A. H., Prins, J. M., and Sigaloff, K. C. E.
- Abstract
Additional file 2. Appendix SB. Methods risk of bias assessment.
- Published
- 2022
- Full Text
- View/download PDF
10. Additional file 4 of [18F]FDG-PET/CT in Staphylococcus aureus bacteremia: a systematic review
- Author
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Buis, D. T. P., Sieswerda, E., Kouijzer, I. J. E., Huynh, W. Y., Burchell, G. L., Berrevoets, M. A. H., Prins, J. M., and Sigaloff, K. C. E.
- Abstract
Additional file 4. Appendix SC. Results risk of bias assessment individual studies with ROBINS-I.
- Published
- 2022
- Full Text
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11. Some days you win
- Author
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Tran, Huynh W. and Panush, Richard S.
- Published
- 2018
- Full Text
- View/download PDF
12. Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans
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Nepogodiev D., Omar O. M., Glasbey J. C., Li E., Simoes J. F. F., Abbott T. E. F., Ademuyiwa A. O., Biccard B. M., Chaudhry D., Davidson G. H., Di Saverio S., Gallo G., Ghosh D., Harrison E. M., Hutchinson P. J., Kamarajah S. K., Keller D. S., Lawani I., Minaya-Bravo A., Moore R., Morton D. G., Ntirenganya F., Pata F., Pearse R. M., la Medina A. R. -D., Tabiri S., Venn M. L., Omar A. B. O. M., Bhangu A., Siaw-Acheampong K., Adamina M., Agarwal A., Alameer E., Alderson D., Alakaloko F., Alser O., Arnaud A. P., Augestad K. M., Bankhead-Kendall B. K., Barlow E., Benson R. A., Blanco-Colino R., Brar A., Breen K. A., Buarque I. L., Caruana E. J., Chakrabortee S., Cox D., Cunha M. F., Dawson B. E., Desai A., Drake T. D., Edwards J. G., Elhadi M., Evans J. P., Farik S., Fiore M., Fitzgerald J. E., Ford S., Gomes G. M. A., Griffiths E. A., Gujjuri R. R., Halkias C., Heritage E., Isik A., Jenkinson M. D., Jones C. S., Khatri C., Keatley J. M., Kolias A., Lawday S., Lederhuber H., Leventoglu S., LAffler M. W., Martin J., Mashbari H. N., Mazingi D., Mckay S. C., Metallidis S., Mohan H. M., Moszkowicz D., Moug S., Ng-Kamstra J. S., Niquen M., Outani O., Pellino G., Pinkney T. D., Pockney P., Radenkovic D., Roberts K., Roslani A. C., Santos I., Schache A., Schnitzbauer A. A., Stewart G. D., Shaw R., Shu S., Soreide K., Spinelli A., Sundar S., Tiwari A., Townend P., Trout I. M., Tsoulfas G., van Ramshorst G. H., Vidya R., Vimalachandran D., Warren O., Wilkin R. J. W., Wright N., Hoste E., Huyghens L., Jacobs R., Opdenacker G., Poelaert J., Rijckaert D., De Decker K., Foubert L., De Neve N., Biston P., Piagnerelli M., Collin V., den Blauwen N., Clauwaert C., De Crop L., Verbeke A., Derumeaux P., Gardin C., Kindt S., Louage S., Verhamme B., DruwACopyright P., Lahaye I., Rosseel F., Rutsaert R., Vanlinthout L., De Kock M., Forget P., Kahn D., Lois F., Momeni M., Yemnga A. P. B., Jadoul J. -L., Malbrain M., Bosinceanu D., Collard E., Jorens P., Reyntiens D., Smitz C., Vercauteren M., Fagnoul D., Toplice K., OremuA¡ K., BeA¡lic G., Duzel V., Hauptman A., Peremin S., Aribar A., Aupcic M., Brod S., Mirkovic I., Bauer Z. A., Belavic M., BlaA¾anin B., KatuA¡in M. L., Krijan A. B., MiA¡kovic P., Aimic-Korac N., Topic J., Ailic A., Aunic J., Acan I., Adanic M., Ivanov N., Aaric J. P., Tomulic K., Viskovic N., BoA¡njak S., Drenjancevic I. H., Kristek G., Kvolik S., Markic S., Rakipovic A. S., Tot O. K., Fabris L. K., Bacak-Kocman I., Balenovic I., Bandic D., Deutsch P. A. J., Divjak L., Filipovic I. G., GuA¾vinec Z., Krznaric Z., Loncaric Y., MagaA¡ J. V., Mitrovic M., Okic M., Pavlek M., Ramov E., Rezek K., Sekulic A., Tomasevic B., Miric M., TomaA¡evic A., Mahecic T. T., Vrbanovic V., Bobinac M., BoA¾ic A., Debelic D., Frkovic V., Batinica I. M., Baranovic S., Gavranovic A., Kikec M., Maldini B., Maric S., Agnic I., Delic N., Dropulic N., GaA¡pic T. K., Ilic D., Ivancev B., Karanovic N., KuA¡cevic D., Marovic Z., Milic M., NeveA¡canin A., Petkovic T., Smoje M., Brozovic G., Goranovic T., Jelisavac M., Matolic M., Mazul-Sunko B., Oberhofer D., Pavicic A. M., Aakic K., Bozovic M. D., Krecek Z. K., Krobot R., Andabaka T., Bratanic M., Dzepina O., Kraljev M., Aeric J., Aimurina T., Grujic R., Nacevski-Bulaja B., BariA¾on M., Danira V., DraA¾en B., DuA¡anka K., HaluA¾an M. B., JoA¡ko A., Katica R., Labor M., Marinkovic T. G., Mihovilcevic D., Marija B., Srecko M., Drab M., Hudacek K., Krikava I., Stourac P., BrabcovA¡ M., KlozovA¡ R., Vajter J., Vymazal T., Toft P., Blichfeldt L., Hansen B. D., Moller K., Nielsen J. S., Frederiksen J., Andersen J. D., KA¼hne J. P., Leivdal S., Stendell L., Simonsen M., Zoltowski M. K., Ali Z. S., Freundlich M., Pilypaite J., Clausen N. G., Thorup L., Hansen F., Bestle M., Hansen C. S., Afshari A., Bille A. B., Lefort M., Secher E. L., Liboriussen L., Herodes V., HA¤rma E., Marvet K., Pool K., Kallas P., MA¤gi T. -K., SA¼tt J., Vijar K., Visk E., Vinnal M., Ellermaa J., Liibusk L., Hovilehto S., Kirsi A., Mustola S., Tiainen P., Toivonen J., Dabnell S., Kaminski T., Sysimetsa A., Kaukonen M., Silvasti P., Vainio K., Lund V., SjAvall S., Saarinen K., Viitanen M., Ahonen T., AlaspA¤A¤ A., Zittling R., Saarinen A., Moisander A., Wagner B., Laru-Sompa R., Elomaa E., Lavonen L., Nevantaus J., Geier K., Kavasmaa T., Koorits U., Kubjas M., Lauritsalo S., Ottelin L., Palve M., PynnAnen J., RA¤A¤bis I., Saarelainen M., HeikkilA¤ T., Kontula T., LehtimA¤ki M., Liimatainen J., Moilanen-Oikarinen M., Pakarinen M., Palanne R., SeppA¤nen H., Pulkkinen A., VA¤A¤rA¤niemi H., Kajaani, Paananen S., Koskenkari J., SA¤lkiA S., Vakkala M., Koskue T., Loisa P., Laitio R., HautamA¤ki R., Koivisto S. -P., Leon A., Bonnet F., Marret E., Spielvogel C., Papageorgiou C., Szymkiewicz O., Tounou-Akue F., Aubrun F., Bonnet A., Gazon M., Guiraud M., Laurent V., Tachon G., Demars N., Dumenil A. -S., Mercier F. J., Landais A., Mentec H., Bazin M., Futier E., Gonnu S., Petit A., Albaladejo P., Almeras L., Rossi-Blancher A. B. M., Lefrant J. Y., Barthel F., Hallel D., Sbai H., Khalifeh P., Lidzborski L., Jully M., Platon E., Pottecher J., Baumgarten R., Schultz C., ElMiloudi F., Lefebvre J., Waton K., Sprunck A., Steib A., Thibaud A., Thuet V., Kieffer V., Dubois-Vallaud D., Jacob L., Becanne X., Cherfaoui S., Gauzit R., Godier A., Lakhdari M., Samma C. M., Halchini C., Lacroix M., Pinna F., Barbes A., Just B., Mateu P., Benayoun L., Berger P., Granier N., Perrigault P. F., Libert N., De Rudnicki S., Merat S., Bourdet B., FerrACopyright F., Minville V., Piriou V., Rague P., Wallet F., Lebuffe G., Desbordes J., Robin E., Ichai C., Orban J. -C., Gottschalk A., Piontek A., Unterberg M., Hilpert J., Kees M., Triltsch A., Wiegand-LAhnert C., GlAckner C., Hohn A., Rose E., SchrAder S., Wiese O., Awlakpui E., Hoeft A., Scheidemann M., Wittmann M., Ramminger A., Dresden C., de Abreu M. G., Heller A. R., Marx C., Neidel J., Goldmann A., von Heymann C., Laetsch B., Maahs E., Scholz L., Frenzel D., Massarat K., Lenhart F. -P., Reichle F., Rudlof K., Borchers F., Buettner C., Schmutzler M., Lucht A., Wagner J., Wuppertal H. K., Pilge S., Schneider G., Untergehrer G., Bis B., Krassler J., Dittmann J., Haberkorn J., Eberitsch J., Eberitsch K., Nippraschk T., Wepler U., Engelen W. -C., Nau C., Scholler A., SchA¼ttler J., Wintzheimer S., Bloos F., Braune A., Fergen D., Ludewig K., Paxian M., Reinhart K., Graf N., Schwarzkopf K., Berger K., Habicher M., Kasperiunaite R., Savelsberg S., Krep H., Reindl M., Bauer W., Bingold F., Christ S., Friederich P., Kaviani R., Auer P., BonnlA¤nder G., Drescher J., Braun R., Eichenauer T., Kerner J., Bierbaum K., BrA¼nner H., Grond S., Perez-Platz U., Andresen B., Linstedt U., Stegmann N., Erkens U., Kopcke J., Meyer A., Brestrich H., Ernst S., Merkel S., Krieger L., Luers F., Weyland A., Noeldge-Schomburg G., Wasmund C., Bredtmann R. -D., Erler I., Haumann C., MAllemann A., Oehmichen U., Sergejewa O., Lehning B., Czeslick E., Geyer M., Malcharek M., Sablotzki A., Stier M., Feld F., Marx G., Rossaint R., Simon V., Armaganidis A., Kotanidou A., Nanas S., Papastylianou A., Psevdi A., Stathopoulos A., Voulas A., Kanna E., Koutsikou A., Moustaka A., Chovas A., Komnos A., Zafiridis T., Franses J., Lavrentieva A., Koraki E., Katsenos C., Kasianidou M. F., Nasopoulou P., Spyropoulou E., Gousia C., Katsanoulas C., Lathyris D., Kyriazopoulos G., Sfyras D., Tsirogianni A., Kostopanagiotou G., Koulenti D., Lignos M., Matsota P., Christopoulos C., Mouratidou A., Vrettou E., Boufidis S., Moka E., Arnaoutoglou E., Koulouras V., Nakos G., Papathanakos G., Anthopoulos G., Choutas G., Karapanos D., Tzani V., Gkiokas G., Nastos K., Nikolakopoulos F., Dragoumanis C., Nikitidis N., Pneumatikos I., Theodorou V., Zacharouli D., Kandi S., Tasopoulos K., Arvaniti K., Matamis D., Mplougoura E., Petropoulou P., Soumpasis I., Amaniti E., Giannakou-Peftoulidou M., Gkeka E., Soultati I., Kokinou M., Papatheodorou L., Stafylaraki M., Giasnetsova T., Gritsi-Gerogianni N., Kydona C., Kiskira O., Koulentis I., Apsokardos A., Dimitropoulos K., Soldatou O., Nathanail C., Papazotos A., Tsakas P., Clouva-Molyvdas P. -M., Kolotoura A., Sartzi M., Papanikolaou S., Polakis P., Karatzas S., Kyparissi A., Papavasilopoulou T., Koukoubani T., Mastora E., Nyktari V., Malliotakis P., Papaioannou A., Bekos V., Maragkou E., Spring A., Ioakeimidou S. E. A., Noulas N., MolnA¡r Z., CsA¼llAg E., Elekes E., MolnA¡r T., Katona Z., Kremer I., Miko A., Budapest, Csomos A., Galambos Z., Szucs A., Szekeres G., Szabo E., Kranitz K., Simon M., Szigeti J., GaA¡l E., Havas A., Ille A., Miskolc, BrA¡z K., Nagy G., Hafeez P., Hanumanthaiah D., Brohan J., O'Chroinin D., Bailey K., Ramamoorthy K. G., Doyle Y., Freir N., O'Rourke J., Jonson P., Saeed S., Hayes I., Loughrey J., Frohlich S., McCauley N., Ryan D., Fitzpatrick G., Kevin L., Thomas J., Warde B., Woolhead A., Duggan M., Egan C., Crowley S., Lebese S., Bergin A., Westbrook A., Page R., Collins D., McKenny M., Bresciani A., Carmino L., Ghelfi S., Lorenzelli L., Novelli M. T., Pescarmona C., Roasio A., Gatta A., Nastasi M., Sanseverino M., Tinti C., Bianchin A., Tormena M. P., Franco A., Marini F., Di Mauro P., Rapido F., Tommasino C., Bellotti F., Boninsegna D., Castellani G., Sances D., Spano G., Tredici S., Vezzoli D., Fucecchio I., Bacci A., Coppini R., Dell'unto S., Mori E., Stanzani M. R., Tosi M., Collareta M., Forfori F., Franchi M., Mancino G., Battistella M., Baricocchi E., Bona F., Debernardi F., Giacoletto G., Iacobellis A., Massucco P., Moselli N., Muratore A., Palomba G., Sardo E., Suita L., Zocca E., Bucci B., Corte F. D., Piciucco T., Viarengo V., Cantarini E., Giampieri M., Tanfani A., Recchia E., Bignami E., Bruno G., Costagliola R., Gandolfi A., Greco M., Lembo R., Monti G., Nicelli E., Pasculli N., Turi S., Rocca G. D., Baroselli A., Brazzoni M., Buttazzoni M., Buttera S., Centonze C., Serena G., Spagnesi L., Toretti I., Vilardi A., Zearo E., Arpino I., Baraldi S., Guarnerio C., Molene V., Monea M. C., Vaccarisi E., Vicari L., Albante A., Aversano M., Loiacono C., Marandola M., Fusari M., Petrucci N., Galla A., Mascia A., Primieri P., Di Noto A., Gratarola A., Molin A., Pelosi P., Spagnolo L., Spena C., Calligaro P., Marchiotto S., Merlini A., Pedrazzoli E., Perina G., Visentin R., Fumagalli R., Garbagnati A., Manetti B., Snaier C., Somaini M., Farnia A., Nani R., Pierantonio N., Grasso S., Gazzanelli S., Pugliese F., Ruberto F., Bergamini E., Tassinati T., Capuzzo M., Cirillo V., Tufano R., Oggioni R., Parrini V., Brunori E., Capone M., Carbone L., Corradetti F., Elisei D., Fiorentino S., Francesconi M., Gattari D., Gorgoglione M., Iacobone E., Minnucci F., Montironi C., Riccioni G., Tappata G., Zompanti V., Verdenelli P., Cerutti E., Ranieri V. M., Grigorjevs S., Rikmane M., Rozkalne D., Stepanovs J., Suba O., Golubovska I., Kazune S., Miscuk A., Nemme J., Oss P., Sipylaite J., Macas A., Ragaisis V., Kontrimaviciute E., Tomkute G., Boerma E. C., Leeuwarden M. C., Kramer I. F., Poeze M., Maria J., Pelzer G., Nijsten M., Schoorl M., Spanjersberg R., Buhre W., Dieleman S., van Klei W. A., Bouw M., Pickkers P., Schreiner F., Zandvliet R., van den Berg R., De Wit E., Keijzer C., Hollmann M. W., Preckel B., van Acker G. J. D., Dennesen P. J. W., Kuijpers-Visser A. G., Inan T., Gemert A. W. M. M. K. -V., Ponssen H. H., Brouwer T., Koopmans M., van Bommel J., van Duijn D., van der Hoven B., Ormskerk P., Beck O., Schiere S., Reidinga A. C., Venema A., Jammer I., Dokka V., Monsen S. A., Ytrebo L. M., Noursadeghi M., Shahzad A., Boksasp O. D., Roiss C., Strietzel H. F., Berntsen A. G. S., Haugland H., Vingsnes S. O., Axelsson P., Risom Olsen T. C., Katre S., Aakeroey K., Tamowicz B., Bozilow D., Goch R., Grabowski P., Kupisiak J., Mallek M., Szyca R., Kostyrka W., Choma R., Jankowski G., Koscielniak W., Pietraszek P., Szarowar B., FranA§a C., Lacerda A. P., Ormonde L., Rosa R., Pereira I., Vitor P., Bento H. C., Carvalho M. R. L. M., Faria M., Almeida E., Mealha R., Vicente R., Monte R., Rua F., Barros N., Esteves F., Pinheiro C. M. G., Real V., Oliveira V. M., Oliveira M. F., Martins I., Saraiva J. P., AssunA§A£o J. P., BA¡rtolo A., Carvalho A., Correia C., Martins S., Milheiro R., Diaz A., GonA§alves M. I., Ribeiro R., Estilita J., GlAria C., de Almeida J., Barros F., Ramos A., Camara M., Maul E. R., Nobrega J., Langner A., Maia D. F., Afonso O., Faria F., Serra S., Botelho M. M., Ferreira P., MourA£o L., Oliveira A. V., Resende M., Aleman M., Fonseca J., Isidoro M., de Meneses H., PAªgas A., Pereira J., Pereira L., Ramos B., Matos F., Matos R., de Lurdes GonA§alves Castro M., Martins A., Ramos C., de Sousa M., Bento L., Botas C., Lopes V., Mendes R., Blaj M., Damian M., Lupusoru A., Ristescu I., Codreanu M., Diaconescu C., Nistor A., Stelian D. S., Streanga L., Berneanu M., Bordeianu C., Florenta C., Iacob A., Lupu M. N., Mocanu I., Moraru C., Meran C., Nicolae B., Sandu M., Turcanu R., Epure F., Grigore M., Hotaranu C., Popescu N., Baban O., Baciu M., Ciobanu A., Maftei I., Moldovan I., Ungureanu L., Bogdan P., Corneci D., Dinu M., Madalina D., Rely M., Silvius N., Tomescu D., Gabriela D., Dinescu S. 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O., Aleksic D., Gerjevic B., Kalan K., Ursic T., Artigas A., Garcia A., Lisi A., Perez I., Perez G., Poch N., Vaquer S., Balciscueta G., Barrasa H., Cabanes S., Maynar J., Poveda Y., Rodero A. Q., Vallejo A., Duque P., Garcia-Bunger B., Elvira M. A., Lajara A. M., Palencia M., Ramos R., Fernandez A. S., LeAn J. P. T., LApez J. I., Murillo F. J. Y., Ramirez E. T., Rico P. U., Patricia M., VizcaAno M., Alvarez M. J. B., Real K. P., Serra A. M., Aracil N., Bodega B. M., GarcAa R. F., GarcAa M. A., de la Quintana Gordon B., JodrA¡ A. G., LApez A. D. S., Ros J. J. L., Soto R. A., SepAºlveda I., DAez E. P., FernA¡ndez L. F., Gulina C. S., Arviza L. P., Fernandez L. M., GAmez A. R., MartAnez C. A., RodrAguez A. B. R., Soto C. L., Aldecoa C., Garcia C., Lorenzo M., Pinilla E., Rico J., Ruperez I., Alonso E., Leira F., Maseda D. P. E., Royo C., Villagran J., Candi G. M., Esteva G. E., Folgado R. M., Fornaguera N. J., Montse P. C., Prat A. S., Sintes D., Arteta D. A., Delgado H. 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J., Williams S., Kaura V., Lanka P., Naylor C., Ahmed A., Myatt J., Shenoy R., Soon W.C., Tan J., Karadia S., Self J., Durant E., Tripathi S., Bullock C., Ghosh A., Bengeri S., Cowton A., Khalid M.S., Limb J., McAdam C., Porritt M., Shekar P., Harden C., Hollands H., King A., March L., Minto G., Patrick A., Waugh D., Kumara P., Simeson K., Yarwood J., Browning J., Julian H., Newton M., Pernu P.K., Wilson A., Commey T., Foot H., Glover L., Gupta A., Lancaster N., Levin J., Mackenzie F., Mestanza C., Nofal E., Pout L., Varden R., Wild J., Jones S., Davies C., Martin M., Thomas S., Burns K., McArthur C., Patel P., Lau G., Rich N., Davis F., Port B., Prout R., Smith C., Adelaja Y., Bennett V., Dumitrescu A., Murphy J.F., Keen A., Mguni N., Ong C., Adams G., Boshier P., Brown R., Butryn I., Chatterjee J., Freethy A., Tsakok M., Tsiligiannis S., Peat W., Stephenson L., Bradburn M., Pick S., Cunha P., Olagbaiye O., Tayeh S., Abernethy C., Balasubramaniam M., Bennett R., Bolton D., Martinson V., Bell S., Heather B., Kushakovsky V., Alcock L., Alexander H., Anderson C., Baker P., Brookes M., Cawthorn L., Cirstea E., Colling K., Coulter I., Das S., Haigh K., Hamdan A., Hugill K., Kottam L., Lisseter E., Mawdsley M., McGivern J., Padala K., Phelps V., Stewart K., Towse K., Tregonning J., Vahedi A., Walker A., Baines D., Bilolikar A., Chande S., Dunk N., Kulkarni R., Kumar P., Metodiev Y., Ncomanzi D., Raithatha B., Raymode P., Szafranski J., Twohey L., Watt P., Weatherall L., Weatherill J., Whitman Z., Wighton E., Abayasinghe C., Chan A., Darwish S., Gill J., Glasgow E., Harris C., Kochhar A., Mellis C., Pool A., Riozzi P., Selman A., Smith E.-J., Vele L., Gercek Y., Guy K., Holden D., Watson N., Whysall K., Andreou P., Hales D., Thompson J., Bowrey S., McDonald S., Gilmore J., Hills V., Kelly C., Kelly S., Lloyd G., Abbott T., Gall L., Torrance H., Vivian M., Berntsen E., Nolan T., Vohra A., Brown A., Clark R., Coughlan E., Daniel C., Patvardhan C., Pearson R., Predeep S., 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S.A., Chukkambotla S., Andrew A., Attrill E., Campbell G., Datson A., Fouracres A., Graterol J., Graves L., Hong B., Ishimaru A., Karthikeyan A., King H., Lawson T., Lee G., Lyons S., Hall A.M., Mathoulin S., Mcintyre E., Mclaughlin D., Mulcahy K., Robbins J., Sung W., Tayo A., Trembath L., Venugopal S., Wigmore G., Boereboom C., Downes C., Humphries R., Melbourne S., Tou S., Ullah S., Boxall L., Broomby R., Deen T., Hellewell A., Helliwell L., Hutchings M., Hutchins D., Keenan S., Mackie D., Potter A., Smith F., Stone L., Thorpe K., Wassall R., Woodgate A., Baillie S., Campbell T., James S., King C., de Araujo D.M., Martin D., Morkane C., Rajendram R., Burton M., James K., Keevil E., Minik O., Morgan J., Musgrave A., Rajanna H., Roberts T., Adamson M., Jumbe S., Kendall J., Muthuswamy M.B., Cruikshanks A., Wrench I., Zeidan L., Ardern D., Harris B., Hellstrom J., Varsani N., Brown C.W., Docherty P., Gillies M., McGregor E., Usher H., Bodger P., Creary T., Fowler A., Ijuo E., Jones T., Kantsedikas I., Lahiri S., McLean A.L., Phull M., Baldwin J., Doyle D., Mcmullan S., Oladapo M., Owen T., Williams A., Gregory P., Husain T., Mathers E., Montague L., Avis J., Cook T., Dali-Kemmery L., Kerslake I., Lambourne V., Pearson A., Boyd C., Lawson C., McCrossan R., Nesbitt V., O'connor L., Sinclair R., Farid N., Morgese C., Bhatia K., Karmarkar S., Ahmed J., Branagan G., Hutton M., Swain A., Brookes J., Cornell J., Dolan R., van Vuuren A.J., Jowitt T., Kalashetty G., Lloyd F., Patel K., Sherwood N., Chandler B., Deighton K., Emma T., Haunch K., Cheeseman M., Dent K., Gray C., Hood M., Jones D., Juj J., Rao R., Walker T., Cheah C., Cheing Y., Coutinho F., Gondo P., Hadebe B., Hove M.O., Krishnachetty B., Rhodes K., Sokhi J., Baker K.-A., Bertram W., Looseley A., Arya S., Balfoussia D., Baxter L., Harris J., Jones C., Knaggs A., Markar S., Perera A., Scott A., Shida A., Sirha R., Wright S., Frost V., MacGregor M., Andrews E., Arrandale L., Barrett S., Cifra E., Cooper M., Dragnea D., Elna C., Maclean J., Meier S., Milliken D., Munns C., Ratanshi N., Salvana A., Watson A., Ali H., Critchley R., Hicks C., Liddle A., Pass M., Ritchie C., Thomas C., Too L., Welsh S., Gill T., Johnson J., Reed J., Davis E., Papadopoullos S., Attwood C., Biffen A., Boulton K., Gray S., Hay D., Mills S., Riddell R., Simpson J., Bhardwaj N., Paul E., Uwubamwen N., Alexander M., Arrich J., Arumugam S., Blackwood D., Boggiano V., Chatterjee D., Chhabra A., Christian R., Costelloe H., Matthewman M.C., Dalton E., Darko J., Davari M., Dave T., Deacon M., Deepak S., Edmond H., Ellis J., El-Sayed A., Eneje P., English R., Ewe R., Foers W., Franklin J., Gallego L., Garrett E., Goldberg O., Goss H., Greaves R., Harris R., Hennings C., Jones E., Kamali N., Kokkinos N., Lewis C., Lignos L., Malgapo E.V., Malik R., Milne A., Mulligan J.-P., Nicklin P., Palipane N., Parsons T., Piper R., Prakash R., Ramesh B., Rasip S., Reading J., Rela M., Reyes A., Robert S., Rooms M., Shah K., Simons H., Solanki S., Spowart E., Stevens A., Waggett H., Yassaee A., Kennedy A., Scott S., Somanath S., Berg A., Hernandez M., Nanda R., Tank G., Wilson N., Wilson D., Al-Soudaine Y., Baldwin M., Cornish J., Davies Z., Davies L., Edwards M., Frewer N., Gallard S., Glasbey J., Harries R., Hopkins L., Kim T., Koompirochana V., Lawson S., Lewis M., Makzal Z., Scourfield S., Ahmad Y., Bates S., Blackwell C., Bryant H., Coulter S., Cruickshank R., Daniel S., Daubeny T., Helen B., Hinxman H., Levett D., Skinner B., Walsgrove J., Dickson J., Constantin K., Karen M., O'Brien P., O'Donohoe L., Sundayi S., Brooke J., Cardy J., Humphreys S., Kessack L., Kubitzek C., Cotterill D., Hodzovic E., Hosdurga G., Miles E., Saunders G., Campbell M., Jemmett K., Raj A., Naik A., Ramamoorthy R., Shah N., Sylvan A., Blyth K., Johnson E., Lo P., Martin T., Plunkett E., Allison J., Carroll C., Craw N., Craw S., Pitt-Kerby T., Rowland-Axe R., Spurdle K., McDonald A., Simon D., Sinha V., Banner-Goodspeed V., Boone M., Campbell K., Lu F., Scannell J., Sobol J., Balajonda N., Clemmons K., Conde C., Funk B., Hopkins T., Olaleye O., Omer O., Pender M., Porto A., Waweru P., Yeh E., Bodansky D., Evans A., Kleopoulos S., Maril R., Mathney E., Sanchez A., Tinuoye E., Bateman B., Eng K., Jiang N., Ladha K., Needleman J., Chen L.-L., Lane R., Robinowitz D., Ghushe N., Irshad M., Takemoto S., Wallace A., Mazzeffi M., Rock P., Wallace K., Zhu X., Chua P., Mattera M., Sharar R., Thilen S., Treggiari M., Morgan A., Sofjan I., Subramaniam K., Avidan M., Maybrier H., Muench M., Wildes T., Elkhogia A.M., Omigbodun A.O., Antwi-Kusi A., Samateh A.L.S., Ndonga A., Basenero A., Mbwele B., Gordon C.S., Youssouf C., Ashebir D.Z., Munlemvo D.M., Zoumenou E., Madzimbamuto F., Ndayisaba G., Sama H.D., Ndasi H., Kluyts H.-L., Tumukunde J., Fawzy M., Mehyaoui R.M., Amanor-Boadu S.D., Rakotoarison S., Esterhuizen T.M., Patel U., Gobin V., Le Manach Y., Ngumi Z., Mehyaoui R., Kanoun H., Chelbi L., Alghazali A., Metali A., Mokretar R., Ouanes F., Imessaoudene Z., Khalfallah, Guenane M., Sadat S., Gadi B., Benali D., Chikh N., Laksari M., Boufas F., Akodjenou J., Gbehade O., Mewanou S., Djessouho E., Ahossi R., Abadagan H., Guegni A., Assoum G., Zomahoun L., Oscar K., Souhe R., Dewanou H., Nascimento R., Guezo M., Adjignon S.V., Anani F., Allaye T., Tchegnonsi C., Fanou L., Hadecon R., Atomabe A., Tchaou B., Horugavye E., Habimana L., Nkesha T., Manirimbere C., Ndikumana R., Niyondiko J.C., Minani P., Bigirimana F., Uwiteyimbabazi J., Konwuoh N.D., Ekwen G., Kaggya M., Constance N., Samuel N., Akanyun S., Freeman T., Royas L., Tchoupa M., Simo W.A.G., Ngouane D., Tanjong B.N., Bouya A.P., Carlos F., Gallou P.D., Prosper A., Athombo J.S., Sanduku D.K., Mampangula Y., Nziene V.N., Odia P.K., Mbombo W.D., Wms M., Mukuna P.M., Boloko P.M., Mvwama N.M., Jjn I., Manzombi J.K., Mvwala K.R., Ilunga J.P.M., Mawisa T., Kilembe A.M., Bikuelo C.J., Mwepu I.M., Mwaluka C.N., Sarah H.N., Kukembila A.M., Diyoyo M.P., Ngalala A.M., Kabango R., Kongolo M., Mbayabu M., Namegabe E.S., Bula Bula I.M., Likongo T.B., Pengemale G.N., Bingidimi S.S., Imposo D.H., Matondo P.M., Lelo S.N., Kamanda R.J., Kady N., Ntueba B., Christian M., Badianga E.K., Clc L., Mubeya F.K., Bahta M.T., Kassa S.K., Assefa S.B., Girmaye G.T., Samateh A.L., Janneh L., Sanyang L.N., Nyassi M.T., Grey-Johnson S.V., Villarreal R., Antunez O., Jallow C.S., Roberts C.A., Clegg-Lamptey J.N., Kutor Y.Y., Adu-Aryee N.A., Domoyyeri D.P., Atito-Narh E., Anabah T.W.A., Ndonga A.K.N., Ngumi Z.W.W., Bitta C., Nyawanda H.O., Oduor O.E.O., Okelo O.S., Ogendo S.W.O., Ngari N.B.M., Nyokabi N.N., Chokwe T.M., Gacii V.M., Githae B., Gatheru A.P., Maranga O., Muriithi J.M., Mwangi C.M., Mwiti T.M., Nabulindo S.M., Ndung'u C., Mugambi J., Mtongwe V.M., Kiprop B., Mbadi R., Wambugu P.K., Hersi S., Mutahi S., Aluvale J.S., Gitau S., Kariuki K., Ngatia E., Sitima S., Obadiah S., Mwenda V., Iraya A.M., Waweru E.N., Muturi A., Miima S., Ojujo M., Mossy P., Macharia I., Gakenia A., Mitema F., Manvinder M., Kipng'etich B., Njoroge M., Ndegwa D., Karanja J.K., Muchiri K., Makori O., Kibochi W., Mathangani W., Swaleh A., Wafula A., Maina S.N., Njenga P.W., Okonu N., Maghrabi M., Saed S.S., al Shams E.S., Shkirban A.S., Alakkari E.A., Gweder M.G., Baghni R.B., Alsabri S.A., Hebli S.H., Elghandouri M., Shanin S.H., Rokhsi S., Hensheri M.E.L., Eltaguri M., Elyasir I.E., Alwahedi H.W., Almoraid F., Anjar N., Alkilani A., Ghnain A., Senusi F.S., Elsaity R., Almajbery A., Abokris A., Montenegro L., Mohammed F.A.M., Hammouda M., Elsaadi G., Makhlouf N.M., Elzoway A.Z., Abuzalout T.S., Elmehdawi H., Alhendery A.A., Tarhuni A., Feituri A., Benamour A.S.B., Alkobty F.A., Azzaidey H.M.Z., Mohammed N.M., Elghazal Z.S.E., Alhoty F.F.H., Abugassa S.O.A., Al-Zubaidy K., Ilbarasi M.N., Alalem R., Swayeb E., Zubia N.Z., Mohamed P., Teeka M.O., Sohoub A., Abushnaf A., Mohamed A., Ramadan L., Shubba A., Huwidi O., Al-Serksi M., Eshtiwi M., Hadia E., Ahmed A.-J., Mansour I., Rian J.R., Yousef G., Mohamed S., Ahmed E.-Z., Ahmed B., Jamal Z., Abujanah S.A., Amer A.-A., Yousef O., Abozaid W., Elfagieh M.A., Ali A., Zoobei N.Z., Juwid A., Wafa A., Alatresh O.A., Alashhab M., Elzufri A.M., Aldarrat A.D., Matoug F., Alsellabi B., Alkesa T., Addanfour A., Badi H.B., Elfaghi I.E., Salaheddin E., Hamadi L., Hashmi H., Abd-rouf A., Ahmed M., Karar M., Zidan A., Alraheem A.A., Attia A., Yahya A.A., Otman F., Elmadany H., Gerbel G., Saleh M., Eurayet O., Almesmary R., Mostafa H., Abdurazig S., Dahim L., Jermi K., Koraz M.Y.K., Elghallal A.M., Eshwehdi A.A., Elwerfelli A., Elharati F.T., Elrafifi D., Algbali M., Abuhdema F., Elmadani L., Algedar H.A., Shefren I., Abdulrahman A., Najat N.Z., Elkhwildi R.M., Elgelany S., Abduljalil A., Hdud A., Zentuti H.Z., Khetrish S.B., Zeiton A.Z., Altagazi A.A., Almisslati S.H.A., Gandy Y.G., Jasim I., Alghafoud I.A., Hokoma M., Abusnina S.A., Gwila M., Yahya A.I., Mohammed M., Alqawi O.A., Hasan S.H., 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Z., Juwid, A., Wafa, A., Alatresh, O. A., Alashhab, M., Elzufri, A. M., Aldarrat, A. D., Matoug, F., Alsellabi, B., Alkesa, T., Addanfour, A., Badi, H. B., Elfaghi, I. E., Salaheddin, E., Hamadi, L., Hashmi, H., Abd-rouf, A., Ahmed, M., Karar, M., Zidan, A., Alraheem, A. A., Attia, A., Yahya, A. A., Otman, F., Elmadany, H., Gerbel, G., Saleh, M., Eurayet, O., Almesmary, R., Mostafa, H., Abdurazig, S., Dahim, L., Jermi, K., Koraz, M. Y. K., Elghallal, A. M., Eshwehdi, A. A., Elwerfelli, A., Elharati, F. T., Elrafifi, D., Algbali, M., Abuhdema, F., Elmadani, L., Algedar, H. A., Shefren, I., Abdulrahman, A., Najat, N. Z., Elkhwildi, R. M., Elgelany, S., Abduljalil, A., Hdud, A., Zentuti, H. Z., Khetrish, S. B., Zeiton, A. Z., Altagazi, A. A., Almisslati, S. H. A., Gandy, Y. G., Jasim, I., Alghafoud, I. A., Hokoma, M., Abusnina, S. A., Gwila, M., Yahya, A. I., Mohammed, M., Alqawi, O. A., Hasan, S. H., Rakotoarison, S. R., Albert, F., Hery, A. H., Mamy, R. M., Andriamampionona, A. G. 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C., Nakangombe, P., Musiba, V. E. M., Gama, G. G. N., Mwanga, H. A. M., Mgonja, L., Rink, B., Amisi, B. T., Bangure, L., Rois, W., Rois, I., Sabwa, H. K., Barongo, M. L., Tshisekedi, S. M., Mbuyi, T., Lyimo, T. S. K., Munyika, A. A., Kornilov, A. A., Rwehumbiza, S. S. R., Kumar, M., Makopa, E. K., Njuguna, W., Mavesere, H. P., Kabongo, A. N., Mutasiigwa, M. G. H., Yangazov, Y. M., Masiyambiri, A. T. M., Jannetjies, M. J., Dibwe, D. F., Manyere, D. V., Gorelyk, O., Kabangu, J. K., Gagara, M., Salaou, H., Moutari, M., Bori, I., Ogboli-Nwasor, E. O., Aghadi, K., Mohammed, I., Sarkin-Pawa, A., Yunus, A. A., Ibrahim, A. I., Edaigbini, S. A., Yakubu, Y., Sholadoye, T., Koledale, A. K., Anyanwu, L. J. C., Salisu-Kabara, H. M., Sheshe, A. A., Ekwunife, N. C., Ike, I. A. R., Anele, A., Isiguzo, M., Ihezie, O., Onyegbule, A., Enendu, E. O., Akhideno, I., Desalu, I. S., Bankole, O. B., Ojewola, R. W., Osinowo, A. O., Afolabi, B. B., Menkiti, I. D., Mofikoya, B. O., Osazuwa, M. O., Yusuf, A. S., Adamu, Y. B., Alatise, O. I., Arowolo, O. A., Adisa, A. O., Etuk, E. B., Eyelade, O. R., Ogunbode, O., Shittu, O. B., Idowu, O. K., Ayandipo, O. O., Lawal, T. A., Echem, R. C., Otokwala, J., Jamabo, S., Gueye, S., Allopi, K., Singh, U., Bester, J. J. A., Saaiman, C. R., Alli, A., Bischof, K. E., Hurri, H., Smith, O. I., Elghobashy, A. M., Omoshoro-Jones, J., Murray, R., Basson, C. H., de Wet, J. B., Skinner, G. C., Kransingh, S., Kuhn, W., Madsen, A. S. M., Matubatuba, J. T., Mayeza, S., Naidoo, L. C., Narain, S. J., Nkuebe, T. N., Nabela, L., Nkunjana, M., Mhatu, S., Thomas, B. P., Wynne, E. E., Davids, J. G., Gra¼newald, K. K., Kruger, S., Ras, W. A. P., Venter, P. J., Cacala, S. R. C., Kruse, C., Mahomva, O., Marais, L. C., Semenya, E. M., Rayne, S. R., Alphonsus, C. S., Mbuyisa, M. W., Torborg, A. M., De Lange, J. T., Drummond, L. W., Dullab, K. D., Enicker, B. C., Gigabhoy, R., Hardcastle, T. C., Maharaj, A., Majola, N., Moopanar, M., Mukama, I. F., Naicker, K., Ngcobo, G. K., Ramnarain, H., Rocher, A. G. L., Singh, S., Stoltenkamp, H. L., Alberts, A. N. J. D., Luthuli, L., Lumbamba, A. J. M., Anderson, P. G. R., du Plessis, W. M., Ellis, S., Ford, L. M., Rousseau, F. J., Rousseau, N., Steyn, G., Steyn, H. C., Weideman, M., Church, B., Holford, E. B., Szpytko, A. J., Brouckaert, N. T., Freeman, Y. B. M., Ehouni, A., Jithoo, S., Naidoo, L., Peter, A. M., Belhaj, S., Tun, M., Kapp, P., Bwambale, Y. B., Holder, H., Kasongo, K. J. P., Makhanya, V., Morapedi, M., Mahomedy, N. A., Pillay, V., Reddy, S. R., Mgoqo, N., Mrara, B., Nibe, Z., Ninise, E., Pahlana, S. M., Usenbo, A. O., Malongwe, S. M., Giles, D. G., Porrill, O. S., Reed, A. R., Visser, J., Davies, G. L., Koller, V. L., Moodie, Q. K., Spicer, J. M., Van Dyk, J. G., Diedericks, B. J. S., Esterhuizen, J. L., Mavhungu, R., Mhlari, T. M., Akhter, M., Baloyi, A. M., Bamuza, K. A., Bamuza, M. I., Bashiya, L., Blignaut, F., Machowski, A. Z., Madzivhe, L. J., Mafafo, S. C., Mashile, M. V., Masia, O. R., Masipa, J. N., Matenchi, M. W., Mathe, R. C., Mogale, J. O., Mohlala, M. P., Mongwe, K. N., Morulana, T. G., Motloutsi, S. P., Mphephu, P. E., Muroonga, M. P., Mzezewa, S. Z., Neil, M. C., Neluheni, E. V., Nesengani, D. S., Nesengani, N. T., Netshimboni, L. E., Notoane, I., Omoding, S., Orjiako, O., Perez, N., Pheeha, R. M., Pilusa, K. A., Pochana, M. P., Pupyshev, M., Rambau, M., Ramuntshi, R., Roura, H., Ryabchiy, B. B., Ryndine, V., Sebei, M. P., Moses, V. L., Mungherera, A. R. W., and Pansegrouw, J.
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Adult ,Global Health ,SARS‐CoV‐2 ,Health Services Accessibility ,NO ,cancellation ,Models ,COVID‐19 ,Humans ,Pandemics ,Bayes Theorem ,COVID-19 ,Elective Surgical Procedures ,Health Care Rationing ,Health Policy ,Infection Control ,Models, Statistical ,health care economics and organizations ,Elective Surgical Procedure ,Original Articles ,Statistical ,elective surgery ,Original Article ,human activities ,Human - Abstract
The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19.A global expert response study was conducted to elicit projections for the proportion of elective surgery that would be cancelled or postponed during the 12 weeks of peak disruption. A Bayesian β-regression model was used to estimate 12-week cancellation rates for 190 countries. Elective surgical case-mix data, stratified by specialty and indication (surgery for cancer versus benign disease), were determined. This case mix was applied to country-level surgical volumes. The 12-week cancellation rates were then applied to these figures to calculate the total number of cancelled operations.The best estimate was that 28 404 603 operations would be cancelled or postponed during the peak 12 weeks of disruption due to COVID-19 (2 367 050 operations per week). Most would be operations for benign disease (90·2 per cent, 25 638 922 of 28 404 603). The overall 12-week cancellation rate would be 72·3 per cent. Globally, 81·7 per cent of operations for benign conditions (25 638 922 of 31 378 062), 37·7 per cent of cancer operations (2 324 070 of 6 162 311) and 25·4 per cent of elective caesarean sections (441 611 of 1 735 483) would be cancelled or postponed. If countries increased their normal surgical volume by 20 per cent after the pandemic, it would take a median of 45 weeks to clear the backlog of operations resulting from COVID-19 disruption.A very large number of operations will be cancelled or postponed owing to disruption caused by COVID-19. Governments should mitigate against this major burden on patients by developing recovery plans and implementing strategies to restore surgical activity safely.La pandemia de COVID-19 ha interrumpido los servicios hospitalarios habituales a nivel mundial. En este estudio se calculó el número total de operaciones electivas para adultos que se cancelarían en todo el mundo durante las 12 semanas de interrupción máxima debido a COVID’19. MÉTODOS: Se realizó un estudio global de respuestas de expertos para obtener proyecciones sobre la proporción de cirugía electiva que se cancelaría o pospondría durante las 12 semanas del pico máximo de disrupción. Se usó un modelo bayesiano de regresión beta para estimar las tasas de cancelación durante 12 semanas en 190 países. Se determinaron los datos de la casuística de casos quirúrgicos electivos, estratificados por especialidad e indicación (cáncer versus cirugía benigna). Esta casuística de casos se aplicó a volúmenes quirúrgicos a nivel de país. Las tasas de cancelación de las 12 semanas se aplicaron a estas cifras para calcular el total de operaciones suspendidas.La mejor estimación fue que 28.404.603 operaciones hubieran sido canceladas o pospuestas durante las 12 semanas del pico de disrupción por COVID-19 (2.367.050 operaciones por semana). La mayoría hubieran sido operaciones por enfermedad benigna (90,2%, 25.638.922/28. 404. 603). La tasa de cancelación general en 12 semanas sería del 72,3%. A nivel mundial, el 81,7% (25.638.921/31.378.062) de la cirugía benigna, el 37,7% (2. 324.069/6.162.311) de la cirugía por cáncer y el 25,4% (441.611/1.735.483) de las cesáreas electivas hubieran sido canceladas o pospuestas. Si los países aumentan su volumen quirúrgico normal en un 20% después de la pandemia, se tardaría una mediana de 45 semanas para eliminar la acumulación de operaciones resultantes de la disrupción por COVID’19. CONCLUSIÓN: Se cancelará o pospondrá un número muy grande de operaciones debido a la disrupción causada por COVID-19. Los gobiernos deberían mitigar esta importante carga para los pacientes mediante el desarrollo de planes de recuperación e implementando estrategias para reiniciar de manera segura la actividad quirúrgica.
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- 2020
13. Motor neuron disease: current management and future prospects
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Simon, N. G., Huynh, W., Vucic, S., Talbot, K., and Kiernan, M. C.
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- 2015
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14. Platform Communications: Abstract Book – 33rd International Symposium on ALS/MND (Complete printable file).
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Gage, F., Jones, J., Herdy, J., Mertens, J., Pupillo, E., Bianchi, E., Bendotti, C., Bonetto, V., Paganoni, S., Mazzini, L., Beghi, E., Bensimon, G., Leigh, P.N., Vucic, S., Menon, P., Huynh, W., Mahoney, C., Ho, K., Rynders, A., and Evan, J.
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AMYOTROPHIC lateral sclerosis ,RILUZOLE ,HEAT shock proteins - Abstract
Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. State and metropolitan area-based amyotrophic lateral sclerosis (ALS) surveillance. [Extracted from the article]
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- 2022
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15. Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries
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Ahmad T., Bouwman R. A., Grigoras I., Aldecoa C., Hofer C., Hoeft A., Holt P., Buhre W., Pearse R. M., Clavien P. -A., Demartines N., Grocott M., Haddow J., Moreno R., Pritchard N., Rhodes A., Wilson M., Ahmed T., Halliwell R., Shulman M., Myles P., Schmid W., Hiesmayr M., Wouters P., De Hert S., Lobo S., Beattie S., Wijeysundera D., Fang X., Rasmussen L., Futier E., Biais M., Venara A., Slim K., Sander M., Koulenti D., Arvaniti K., Chan M., Kulkarni A., Chandra S., Tantri A., Geddoa E., Abbas M., Della Rocca G., Sivasakthi D., Mansor M., Luna P., Bouwman A., Beavis V., Campbell D., Short T., Osinaike T., Matos R., Kirov M., Protsenko D., Biccard B., Chew M., Hubner M., Ditai J., Szakmany T., Fleisher L., Ferguson M., MacMahon M., Cherian R., Currow H., Kanathiban K., Gillespie D., Pathmanathan E., Phillips K., Reynolds J., Rowley J., Douglas J., Kerridge R., Garg S., Bennett M., Jain M., Alcock D., Terblanche N., Cotter R., Leslie K., Stewart M., Zingerle N., Clyde A., Hambidge O., Rehak A., Cotterell S., Huynh W. B. Q., McCulloch T., Ben-Menachem E., Egan T., Cope J., Fellinger P., Markus P., Haselberger S., Holaubek C., Lichtenegger P., Scherz F., Hoffer F., Cakova V., Eichwalder A., Fischbach N., Klug R., Schneider E., Vesely M., Wickenhauser R., Gernot K., Leitgeb M., Lang F., Toro N., Bauer M., Laengle F., Haberl C., Mayrhofer T., Trybus C., Buerkle C., Forstner K., Germann R., Rinoesl H., Schindler E., Trampitsch E., Bogner G., Dankl D., Duenser M., Fritsch G., Gradwohl I. -M., Hartmann A., Hoelzenbein T., Jaeger T., Landauer F., Lindl G., Lux M., Steindl J., Stundner O., Szabo C., Bidgoli J., Verdoodt H., Forget P., Kahn D., Lois F., Momeni M., Pregardien C., Pospiech A., Steyaert A., Veevaete L., De Kegel D., De Jongh K., Foubert L., Smitz C., Vercauteren M., Poelaert J., Van Mossevelde V., Abeloos J., Bouchez S., Coppens M., De Baerdemaeker L., Deblaere I., De Bruyne A., Fonck K., Heyse B., Jacobs T., Lapage K., Moerman A., Neckebroek M., Parashchanka A., Roels N., Van Den Eynde N., Vandenheuvel M., Van Limmen J., Vanluchene A., Vanpeteghem C., Wyffels P., Huygens C., Vandenbempt P., Van De Velde M., Dylst D., Janssen B., Schreurs E., Aleixo F. B., Candido K., Batista H. D., Guimaraes M., Guizeline J., Hoffmann J., Lobo F. R. M., Nascimento V., Nishiyama K., Pazetto L., Souza D., Rodrigues R. S., Dos Santos A. M. V., Jardim J., Sa Malbouisson L. M., Silva J., Do Nascimento P., Baio T. H., De Castro G. I. P., Oliveira H. R. W., Amendola C. P., Cardoso G., Ortega D., Brotto A. F., De Oliveira M. C., Rea-Neto A., Dias F., Travi M. E., Zerman L., Azambuja P., Knibel M. F., Martins A., Almeida W., Neto C. N., Tardelli M. A., Caser E., MacHado M., Aguzzoli C., Baldisserotto S., Tabajara F. B., Bettega F., Rodrigues L. H. C., De Gasperi J., Faina L., Nolasco M. F., Da Costa Fischer B. F., De Campos Ferreira M. F., Hartmann C., Kliemann M., Ribeiro G. L. H., Fraga J. M., Netto T. M., Pozza L. V., Wendling P. R., Azevedo C., Garcia J., Lopes M., Maia B., Maselli P., Melo R., Mendes W., Neves M., Ney J., Piras C., Applewhaite C., Carr A., Chow L., Duttchen K., Foglia J., Greene M., Hinther A., Houston K., McCormick T. J., Mikhayel J., Montasser S., Ragan A., Suen A., Woolsey A., Yu H. C., Funk D., Stephen D., Regina D., Heather D., Faisal D., Pridham J., Rowe B., Sampson S., Thiessen B., Zbitnew G., Bernard A., George R., Jones P., Moor R., Siddiqui N., Wolfer A., Tran D., Winch D., Dobson G., Montasser O., Hall R., Baghirzada L., Curley G., Dai S. Y., Hare G., Lee E., Shastri U., Tsui A., Yagnik A., Alvares D., Choi S., Dwyer H., Flores K., McCartney C., Somascanthan P., Carroll J., Pazmino-Canizares J., Ami N., Chan V., Perlas A., Argue R., Huang Y., Lavis K., Mayson K., Cao Y., Gao H., Hu T., Lv J., Yang J., Yang Y., Zhong Y., Zhou J., Zou X., He M., Li X., Luo D., Wang H., Yu T., Chen L., Wang L., Cai Y., Cao Z., Li Y., Lian J., Sun H., Wang S., Wang Z., Wang K., Zhu Y., Du X., Fan H., Fu Y., Huang L., Hwan H., Luo H., Qu P. -S., Tao F., Wang G., Zhang Y., Zhang X., Chen C., Wang W., Liu Z., Fan L., Tang J., Chen Y., Han Y., Huang C., Liang G., Shen J., Wang J., Yang Q., Zhen J., Zhou H., Chen J., Chen Z., Meng B., Ye H., Bi Y., Cao J., Guo F., Lin H., Liu Y., Lv M., Shi P., Song X., Sun C., Sun Y., Wang Y., Zhang M., Chen R., Hou J., Leng Y., Meng Q. -T., Qian L., Shen Z. -Y., Xia Z. -Y., Xue R., Zhao B., Zhou X. -J., Chen Q., Guo H., Guo Y., Qi Y., Wei J., Zhang W., Zheng L., Bao Q., Fei Y., Hu N., Hu X., Lei M., Lv X., Miao F., Ouyang L., Shen C., Wang D., Wu C., Xu L., Yuan J., Zhang L., Zhang H., Zhao J., Zhao C., Zhao L., Zheng T., Zhou D., Zhou C., Lu K., Zhao T., He C., Chen H., Chen S., Cheng B., He J., Jin L., Li C., Li H., Pan Y., Shi Y., Wen X. H., Wu S., Xie G., Zhang K., Lu X., Chen F., Liang Q., Lin X., Ling Y., Liu G., Tao J., Yang L., Cheng Z., Dai H., Feng Y., Hou B., Gong H., Hua C., Huang H., Huang J., Jiang Z., Li M., Lin J., Liu M., Liu W., Luo F., Ma L., Min J., Shi X., Song Z., Wan X., Xiong Y., Yang S., Zhang Q., Zhao W., Zhu X., Bai Y., Dai Q., Geng W., Han K., He X., Ji B., Jia D., Jin S., Li Q., Liang D., Luo S., Lwang L., Mo Y., Qi X., Qian M., Qin J., Ren Y., Xie J., Yan Y., Yao Y., Zhuang X., Ai Y., Du F., He L., Li Z., Li L., Meng S., Yuan Y., Zhang E., Zhang J., Zhao S., Ji Z., Pei L., Dong B., Li J., Miao Z., Mu H., Qin C., Su L., Wen Z., Xie K., Yu Y., Yuan F., Xiao W., Zhu Z., Fu K., Hu R., Huang S., Liang Y., Yu S., Guo Z., Jing Y., Tang N., Wu J., Yuan D., Zhang R., Zhao X., Bai H. -P., Liu C. -X., Liu F. -F., Ren W., Wang X. -L., Xu G. -J., Li B., Ou Y., Tang Y., Yao S., Zhang S., Kong C. -C., Liu B., Wang T., Lu B., Xia Y., Cai F., Chen P., Hu S., Xu Q., Hu L., Jing L., Liu Q., Dan Z., Qiu X., Ren Q., Tong Y., Wen Y., Wu Q., Xia J., Xiong X., Xu S., Yang T., Yin N., Zeng Q., Zhang B., Zheng K., Cang J., Fan Y., Fu S., Ge X., Guo B., Huang W., Jiang L., Jiang X., Shan Q., Wang F., Christiansen I. C., Granum S. N., Rasmussen B. S., Daugaard M., Gambhir R., Brandsborg B., Steingrimsdottir G. E., Jensen-Gadegaard P., Kovgaard K. O., Siegel H., Eskildsen K. Z., Gatke M. R., Wibrandt I., Heintzelmann S. B., Lange K. H. W., Lundsgaard R. S., Amstrup-Hansen L., Hovendal C., Larsen M., Lenstrup M., Kobborg T., Larsen J. R., Pedersen A. B., Smith S. H., Oestervig R. M., Afshari A., Andersen C., Ekelund K., Lilja E., Beloeil H., Lasocki S., Ouattara A., Sineus M., Molliex S., Legouge M. L., Wallet F., Tesniere A., Gaudin C., Lehur P., Forsans E., De Rudnicki S., Maudet V. S., Sojod G., Ouaissi M., Regimbeau J. -M., Desbordes J., Comptaer N., El Manser D., Ethgen S., Lebuffe G., Auer P., Hartl C., Deja M., Legashov K., Sonnemann S., Wiegand-Loehnert C., Falk E., Habicher M., Angermair S., Laetsch B., Schmidt K., Von Heymann C., Ramminger A., Jelschen F., Pabel S., Weyland A., Czeslick E., Gille J., Malcharek M., Sablotzki A., Lueke K., Wetzel P., Weimann J., Lenhart F. -P., Reichle F., Schirmer F., Huppe M., Klotz K., Nau C., Schon J., Mencke T., Wasmund C., Bankewitz C., Baumgarten G., Fleischer A., Guttenthaler V., Hack Y., Kirchgaessner K., Manner O., Schurig-Urbaniak M., Struck R., Van Rebekkazyl, Wittmann M., Goebel U., Harris S., Veit S., Andreadaki E., Souri F., Katsiadramis I., Skoufi A., Vasileiou M., Aimoniotou-Georgiou E., Katsourakis A., Veroniki F., Vlachogianni G., Petra K., Chlorou D., Oloktsidou E., Ourailoglou V., Papapostolou K., Tsaousi G., Daikou P., Dedemadi G., Kalaitzopoulos I., Loumpias C., Bristogiannis S., Dafnios N., Gkiokas G., Kontis E., Kozompoli D., Papailia A., Theodosopoulos T., Bizios C., Koutsikou A., Moustaka A., Plaitakis I., Armaganidis A., Christodoulopoulou T., Lignos M., Theodorakopoulou M., Asimakos A., Ischaki E., Tsagkaraki A., Zakynthinos S., Antoniadou E., Koutelidakis I., Lathyris D., Pozidou I., Voloudakis N., Dalamagka M., Elena G., Chronis C., Manolakaki D., Mosxogiannidis D., Slepova T., Tsakiridou I. -S., Lampiri C., Vachlioti A., Panagiotakis C., Sfyras D., Tsimpoukas F., Tsirogianni A., Axioti E., Filippopoulos A., Kalliafa E., Kassavetis G., Katralis P., Komnos I., Pilichos G., Ravani I., Totis A., Apagaki E., Efthymiadi A., Kampagiannis N., Paraforou T., Tsioka A., Georgiou G., Vakalos A., Bairaktari A., Charitos E., Markou G., Niforopoulou P., Papakonstantinou N., Tsigou E., Xifara A., Zoulamoglou M., Gkioni P., Karatzas S., Kyparissi A., Mainas E., Papapanagiotou I., Papavasilopoulou T., Fragandreas G., Georgopoulou E., Katsika E., Psarras K., Synekidou E., Verroiotou M., Vetsiou E., Zaimi D., Anagnou A., Apostolou K., Melissopoulou T., Rozenberg T., Tsigris C., Boutsikos G., Kalles V., Kotsalas N., Lavdaiou C., Paikou F., Panagou G. -L., Spring A., Botis I., Drimala M., Georgakakis G., Kiourtzieva E., Ntouma P., Prionas A., Xouplidis K., Dalampini E., Giannaki C., Iasonidou C., Ioannidis O., Lavrentieva A., Papageorgiou G., Kokkinoy M., Stafylaraki M., Gaitanakis S., Karydakis P., Paltoglou J., Ponireas P., Chaloulis P., Provatidis A., Sousana A., Gardikou V. V., Konstantivelli M., Lataniotou O., Lisari E., Margaroni M., Stamatiou K., Nikolaidis E., Pnevmatikos I., Sertaridou E., Andreou A., Arkalaki E., Athanasakis E., Chaniotaki F., Chatzimichali C. A., Christofaki M., Dermitzaki D., Fiorentza K., Frantzeskos G., Geromarkaki E., Kafkalaki K., Kalogridaki M., Karydi K., Kokkini S., Kougentakis G., Lefaki T., Lilitsis E., Makatounaki A., Malliotakis P., Michelakis D., Neonaki M., Nyktari V., Palikyra I., Papadakis E., Papaioannou A., Sfakianakis K., Sgouraki M., Souvatzis X., Spartinou A., Stefanidou N., Syrogianni P., Tsagkaraki G., Arnaoutoglou E., Arnaoutoglou C., Bali C., Bouris V., Doumos R., Gkini K. -P., Kapaktsi C., Koulouras V., Lena A., Lepida D., Michos E., Papadopoulos D., Paschopoulos M., Rompou V. A., Siouti I., Tsampalas S., Ververidou O., Zilis G., Charlalampidoy A., Christodoulidis G., Flossos A., Stamoulis K., Tsang M. S. C., Lai M. L., Yip C. P., Chan H. M. H., Law B., Li W. S., Chu H. M., Koo E. G. Y., Lam C. C. J., Cheng K. H., Lam T., Chu S., Lam W. Y., Wong K. W. K., Kwok D., Hung C. Y. J., Chan W. K. J., Wong W. L., Chung C. K. E., Ma S. K., Kaushik S., Shah B., Shah D., Shah S., Ar P., Muthuchellappan R., Agarwal V., Divatia J., Mishra S., Nimje G., Pande S., Savarkar S., Shrivastava A., Thomas M., Yegnaram S., Hidayatullah R., Puar N., Niman S., Indra I., Hamzah Z., Yuliana A., Abidin U. N., Dursin A. N., Kurnia A., Susanti A., Handayani D., Alit M. A., Arya A., Senapathi T. G. A., Utara U. H., Wid W. M., Wima S., Wir W. M., Jehosua B., Kaunang J., Lantang E. Y., Najoan R., Waworuntu N., Awad H., Fuad A., Geddoa B., Khalaf A. R., Al Hussaini S., Albaj S., Kenber M., Bettinelli A., Spadaro S., AlbertoVolta C., Giancarlo L., Sottosanti V., Copetti U. E., Spagnesi L., Toretti I., Alloj C., Cardellino S., Carmino L., Costanzo E., Fanfani L. C., Novelli M. T., Roasio A., Bellandi M. 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I., Cheong, E., Durst, A., Fengas, L., Flatt, J., Glister, G., Narwani, V., Photi, E., Rankin, A., Rosbergen, M., Beaton, C., Horn, R., Hunt, J., Rousseau, G., Stancombe, L., Absar, M., Allsop, J., Drinkwater, Z., Hodgkiss, T., Smith, K., Alexander-Sefre, F., Campey, L., Dudgeon, L., Hall, K., Hitchcock, R., James, L., Winstone, U., Ahmad, N., Bauchmuller, K., Harrison, J., Jeffery, H., Miller, D., Pinder, A., Pothuneedi, S., Rosser, J., Sanghera, S., Swift, D., Walker, R., Bester, D., Cavanagh, S., Cripps, H., Daniel, H., Lynch, J., Pyke, S., Scholefield, J., Whitworth, H., Bottrill, F., Ramalingam, G., Webb, S., Akerman, N., Antill, P., Bourner, L., Buckley, S., Castle, G., Charles, R., Eggleston, C., Foster, R., Gill, S., Lindley, K., Lklouk, M., Lowery, T., Martin, O., Milne, D., O'Connor, P., Ratcliffe, A., Rose, A., Smith, A., Varma, S., Ward, J., Barcraft-Barnes, H., Camsooksai, J., Colvin, C., Reschreiter, H., Tbaily, L., Venner, N., Hamilton, C., Kelly, L., Toth-Tarsoly, P., Dodsworth, K., Foord, D., Gordon, P., Hawes, E., Lamb, N., Mouland, J., Nightingale, J., Rose, S., Schrieber, J., Al 'Amri, K., Aladin, H., Arshad, M. A., Barraclough, J., Bentley, C., Bergin, C., Carrera, R., Clarkson, A., Collins, M., Denham, S., Griffiths, E., Ip, P., Jeyanthan, S., Joory, K., Kaur, S., Marriott, P., Mitchell, N., Nagaiah, S., Nilsson, A., Parekh, N., Pope, M., Seager, J., Serag, H., Tameem, A., Thomas, A., Thunder, J., Torrance, A., Vohra, R., Whitehouse, A., Wong, T., Blunt, M., Wong, K., Giles, J., Reed, I., Weller, D., Bell, G., Birch, J., Damant, R., Maiden, J., Mewies, C., Prince, C., Radford, J., Reynolds, T., Balain, B., Banerjee, R., Barnett, A., Burston, B., Edwards, J., Evans, C., Ford, D., Gallacher, P., Hill, S., Jaffray, D., Karlakki, S., Kennedy, J., Kiely, N., Lewthwaite, S., Marquis, C., Ockendon, M., Phillips, S., Pickard, S., Richardson, J., Roach, R., Smith, T., Spencer-Jones, R., Steele, N., Steen, J., Van Liefland, M., White, S., Faulds, M., Harris, M., Nicol, S., Pearson, S. A., Chukkambotla, S., Andrew, A., Attrill, E., Campbell, G., Datson, A., Fouracres, A., Graterol, J., Graves, L., Hong, B., Ishimaru, A., Karthikeyan, A., King, H., Lawson, T., Lee, G., Lyons, S., Hall, A. M., Mathoulin, S., Mcintyre, E., Mclaughlin, D., Mulcahy, K., Paddle, J., Robbins, J., Sung, W., Tayo, A., Trembath, L., Venugopal, S., Wigmore, G., Boereboom, C., Downes, C., Humphries, R., Melbourne, S., Tou, S., Ullah, S., Batchelor, N., Boxall, L., Broomby, R., Deen, T., Hellewell, A., Helliwell, L., Hutchings, M., Hutchins, D., Keenan, S., Mackie, D., Potter, A., Smith, F., Stone, L., Thorpe, K., Wassall, R., Woodgate, A., Baillie, S., Campbell, T., James, S., King, C., De Araujo, D. M., Martin, D., Morkane, C., Neely, J., Rajendram, R., Burton, M., James, K., Keevil, E., Minik, O., Morgan, J., Musgrave, A., Rajanna, H., Roberts, T., Adamson, M., Jumbe, S., Kendall, J., Muthuswamy, M. 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J., Jowitt, T., Kalashetty, G., Lloyd, F., Kiran, Patel, Sherwood, N., Brown, L., Chandler, B., Deighton, K., Emma, T., Haunch, K., Cheeseman, M., Dent, K., Gray, C., Hood, M., Jones, D., Juj, J., Rao, R., Walker, T., Al Anizi, M., Cheah, C., Cheing, Y., Coutinho, F., Gondo, P., Hadebe, B., Hove, M. O., Khader, A., Krishnachetty, B., Rhodes, K., Sokhi, J., Baker, K. -A., Bertram, W., Looseley, A., Mouton, R., Hanna, G., Arnold, G., Arya, S., Balfoussia, D., Baxter, L., Harris, J., Jones, C., Knaggs, A., Markar, S., Perera, A., Scott, A., Shida, A., Sirha, R., Wright, S., Frost, V., Andrews, E., Arrandale, L., Barrett, S., Cifra, E., Cooper, M., Dragnea, D., Elna, C., Maclean, J., Meier, S., Milliken, D., Munns, C., Ratanshi, N., Ramessur, S., Salvana, A., Watson, A., Ali, H., Critchley, R., Endersby, S., Hicks, C., Liddle, A., Pass, M., Ritchie, C., Thomas, C., Too, L., Welsh, S., Gill, T., Johnson, J., Reed, J., Davis, E., Papadopoullos, S., Attwood, C., Biffen, A., Boulton, K., Gray, S., Hay, D., Mills, S., Montgomery, J., Riddell, R., Simpson, J., Bhardwaj, N., Paul, E., Uwubamwen, N., Alexander, M., Arrich, J., Arumugam, S., Blackwood, D., Boggiano, V., Lam, Y., Chatterjee, D., Chhabra, A., Christian, R., Costelloe, H., Matthewman, M. 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V., Malik, R., Milne, A., Mulligan, J. -P., Nicklin, P., Palipane, N., Parsons, T., Piper, R., Prakash, R., Ramesh, B., Rasip, S., Reading, J., Rela, M., Reyes, A., Stephens, R., Rooms, M., Shah, K., Simons, H., Solanki, S., Spowart, E., Stevens, A., Waggett, H., Yassaee, A., Kennedy, A., Scott, S., Somanath, S., Berg, A., Hernandez, M., Nanda, R., Tank, G., Wilson, N., Wilson, D., Al-Soudaine, Y., Baldwin, M., Cornish, J., Davies, Z., Davies, L., Edwards, M., Frewer, N., Gallard, S., Glasbey, J., Harries, R., Hopkins, L., Kim, T., Koompirochana, V., Lawson, S., Lewis, M., Makzal, Z., Scourfield, S., Ahmad, Y., Bates, S., Blackwell, C., Bryant, H., Collins, H., Coulter, S., Cruickshank, R., Daniel, S., Daubeny, T., Golder, K., Hawkins, L., Helen, B., Hinxman, H., Levett, D., Salmon, K., Seaward, L., Ben, L., Tyrell, B., Wadams, B., Walsgrove, J., Dickson, J., Constantin, K., Karen, M., O'Brien, P., O'Donohoe, L., Payne, H., Sundayi, S., Walker, E., Brooke, J., Cardy, J., Humphreys, S., Kessack, L., Kubitzek, C., Kumar, S., Cotterill, D., Hodzovic, E., Hosdurga, G., Miles, E., Saunders, G., Campbell, M., Chan, P., Jemmett, K., Raj, A., Naik, A., Oshowo, A., Ramamoorthy, R., Shah, N., Sylvan, A., Blyth, K., Burtenshaw, A., Freeman, D., Johnson, E., Lo, P., Martin, T., Plunkett, E., Wollaston, J., Allison, J., Carroll, C., Craw, N., Craw, S., Pitt-Kerby, T., Rowland-Axe, R., Spurdle, K., Mcdonald, A., Simon, D., Sinha, V., Banner-Goodspeed, V., Boone, M., Campbell, K., Lu, F., Scannell, J., Sobol, J., Balajonda, N., Clemmons, K., Conde, C., Elgasim, M., Funk, B., Hopkins, T., Olaleye, O., Omer, O., Pender, M., Porto, A., Waweru, P., Yeh, E., Bodansky, D., Evans, A., Kleopoulos, S., Maril, R., Mathney, E., Sanchez, A., Tinuoye, E., Bateman, B., Eng, K., Jiang, N., Ladha, K., Needleman, J., Chen, L. -L., Lane, R., Robinowitz, D., Ghushe, N., Irshad, M., O'Connor, J., Patel, S., Takemoto, S., Wallace, A., Mazzeffi, M., Rock, P., Wallace, K., Chua, P., Mattera, M., Sharar, R., Thilen, S., Treggiari, M., Morgan, A., Sofjan, I., Subramaniam, K., Avidan, M., Maybrier, H., Muench, M., and Wildes, T.
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operative ,Male ,Pediatrics ,GLOBAL HEALTH ,Cohort Studies ,0302 clinical medicine ,Postoperative Complications ,030202 anesthesiology ,surgical procedures, operative, mortality ,Health care ,statistics and numerical data ,030212 general & internal medicine ,Hospital Mortality ,Prospective Studies ,Prospective cohort study ,Aged, 80 and over ,HIGH-RISK SURGERY ,COMPLICATIONS ,OUTCOMES ,Incidence (epidemiology) ,Middle Aged ,PATIENT MORTALITY ,Female ,SURGICAL MORTALITY ,Cohort study ,Adult ,medicine.medical_specialty ,methods ,03 medical and health sciences ,Anesthesiology ,medicine ,QUALITY ,Humans ,Elective surgery ,postoperative care, statistics and numerical data ,Aged ,Quality of Health Care ,Postoperative Care ,business.industry ,Postoperative complication ,mortality ,CANCER-SURGERY ,surgical procedures ,Anesthesiology and Pain Medicine ,Logistic Models ,VOLUME ,postoperative care, methods ,Human medicine ,Complication ,business - Abstract
Background.The incidence and impact of postoperative complications are poorly described. Failure-to-rescue, the rate of death following complications, is an important quality measure for perioperative care but has not been investigated across multiple health care systems.Methods.We analysed data collected during the International Surgical Outcomes Study, an international 7-day cohort study of adults undergoing elective inpatient surgery. Hospitals were ranked by quintiles according to surgical procedural volume (Q1 lowest to Q5 highest). For each quintile we assessed in-hospital complications rates, mortality, and failure-to-rescue. We repeated this analysis ranking hospitals by risk-adjusted complication rates (Q1 lowest to Q5 highest).Results.A total of 44 814 patients from 474 hospitals in 27 low-, middle-, and high-income countries were available for analysis. Of these, 7508 (17%) developed one or more postoperative complication, with 207 deaths in hospital (0.5%), giving an overall failure-to-rescue rate of 2.8%. When hospitals were ranked in quintiles by procedural volume, we identified a three-fold variation in mortality (Q1: 0.6% vs Q5: 0.2%) and a two-fold variation in failure-to-rescue (Q1: 3.6% vs Q5: 1.7%). Ranking hospitals in quintiles by risk-adjusted complication rate further confirmed the presence of important variations in failure-to-rescue, indicating differences between hospitals in the risk of death among patients after they develop complications.Conclusions.Comparison of failure-to-rescue rates across health care systems suggests the presence of preventable postoperative deaths. Using such metrics, developing nations could benefit from a data-driven approach to quality improvement, which has proved effective in high-income countries.
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- 2017
16. The healing of dental extraction sockets in patients with Type 2 diabetes on oral hypoglycaemics: a prospective cohort
- Author
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Huang, S, Dang, H, Huynh, W, Sambrook, P J, and Goss, A N
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- 2013
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17. Respiratory function and cognitive profile in amyotrophic lateral sclerosis
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Huynh, W., primary, Sharplin, L. E., additional, Caga, J., additional, Highton‐Williamson, E., additional, and Kiernan, M. C., additional
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- 2019
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18. Spontaneous peroneal compartment syndrome causing acute foot drop
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Kehdi, E. E., Huynh, W., Cordato, D. J., Bonura, A., and Hanna, I. Y.
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- 2008
19. Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination
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Tea, F, Lopez, JA, Ramanathan, S, Merheb, V, Lee, FXZ, Zou, A, Pilli, D, Patrick, E, van der Walt, A, Monif, M, Tantsis, EM, Yiu, EM, Vucic, S, Henderson, APD, Fok, A, Fraser, CL, Lechner-Scott, J, Reddel, SW, Broadley, S, Barnett, MH, Brown, DA, Lunemann, JD, Dale, RC, Brilot, F, Sinclair, A, Kermode, AG, Kornberg, A, Bye, A, McGettigan, B, Trewin, B, Brew, B, Taylor, B, Bundell, C, Miteff, C, Troedson, C, Pridmore, C, Spooner, C, Yiannikas, C, O'Gorman, C, Clark, D, Suan, D, Jones, D, Kilfoyle, D, Gill, D, Wakefield, D, Hofmann, D, Mathey, E, O'Grady, G, Jones, HF, Beadnall, H, Butzkueven, H, Joshi, H, Andrews, I, Sutton, I, MacIntyre, J, Sandbach, JM, Freeman, J, King, J, O'Neill, JH, Parratt, J, Barton, J, Garber, J, Ahmad, K, Riney, K, Buzzard, K, Kothur, K, Cantrill, LC, Menezes, MP, Paine, MA, Marriot, M, Ghadiri, M, Boggild, M, Lawlor, M, Badve, M, Ryan, M, Aaqib, M, Shuey, N, Jordan, N, Urriola, N, Lawn, N, White, O, McCombe, P, Patel, R, Leventer, R, Webster, R, Smith, R, Gupta, S, Mohammad, SS, Pillai, S, Hawke, S, Simon, S, Calvert, S, Blum, S, Malone, S, Hodgkinson, S, Nguyen, TK, Hardy, TA, Kalincik, T, Ware, T, Fung, VSC, Huynh, W, Tea, F, Lopez, JA, Ramanathan, S, Merheb, V, Lee, FXZ, Zou, A, Pilli, D, Patrick, E, van der Walt, A, Monif, M, Tantsis, EM, Yiu, EM, Vucic, S, Henderson, APD, Fok, A, Fraser, CL, Lechner-Scott, J, Reddel, SW, Broadley, S, Barnett, MH, Brown, DA, Lunemann, JD, Dale, RC, Brilot, F, Sinclair, A, Kermode, AG, Kornberg, A, Bye, A, McGettigan, B, Trewin, B, Brew, B, Taylor, B, Bundell, C, Miteff, C, Troedson, C, Pridmore, C, Spooner, C, Yiannikas, C, O'Gorman, C, Clark, D, Suan, D, Jones, D, Kilfoyle, D, Gill, D, Wakefield, D, Hofmann, D, Mathey, E, O'Grady, G, Jones, HF, Beadnall, H, Butzkueven, H, Joshi, H, Andrews, I, Sutton, I, MacIntyre, J, Sandbach, JM, Freeman, J, King, J, O'Neill, JH, Parratt, J, Barton, J, Garber, J, Ahmad, K, Riney, K, Buzzard, K, Kothur, K, Cantrill, LC, Menezes, MP, Paine, MA, Marriot, M, Ghadiri, M, Boggild, M, Lawlor, M, Badve, M, Ryan, M, Aaqib, M, Shuey, N, Jordan, N, Urriola, N, Lawn, N, White, O, McCombe, P, Patel, R, Leventer, R, Webster, R, Smith, R, Gupta, S, Mohammad, SS, Pillai, S, Hawke, S, Simon, S, Calvert, S, Blum, S, Malone, S, Hodgkinson, S, Nguyen, TK, Hardy, TA, Kalincik, T, Ware, T, Fung, VSC, and Huynh, W
- Abstract
Over recent years, human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have been associated with monophasic and relapsing central nervous system demyelination involving the optic nerves, spinal cord, and brain. While the clinical relevance of MOG Ab detection is becoming increasingly clear as therapeutic and prognostic differences from multiple sclerosis are acknowledged, an in-depth characterization of human MOG Ab is required to answer key challenges in patient diagnosis, treatment, and prognosis. Herein, we investigated the epitope, binding sensitivity, and affinity of MOG Ab in a cohort of 139 and 148 MOG antibody-seropositive children and adults (n = 287 patients at baseline, 130 longitudinal samples, and 22 cerebrospinal fluid samples). MOG extracellular domain was also immobilized to determine the affinity of MOG Ab. MOG Ab response was of immunoglobulin G1 isotype, and was of peripheral rather than intrathecal origin. High affinity MOG Ab were detected in 15% paediatric and 18% adult sera. More than 75% of paediatric and adult MOG Ab targeted a dominant extracellular antigenic region around Proline42. MOG Ab titers fluctuated over the progression of disease, but affinity and reactivity to Proline42 remained stable. Adults with a relapsing course intrinsically presented with a reduced immunoreactivity to Proline42 and had a more diverse MOG Ab response, a feature that may be harnessed for predicting relapse. Higher titers of MOG Ab were observed in more severe phenotypes and during active disease, supporting the pathogenic role of MOG Ab. Loss of MOG Ab seropositivity was observed upon conformational changes to MOG, and this greatly impacted the sensitivity of the detection of relapsing disorders, largely considered as more severe. Careful consideration of the binding characteristics of autoantigens should be taken into account when detecting disease-relevant autoantibodies.
- Published
- 2019
20. Some days you win
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Huynh W. Tran and Richard S. Panush
- Subjects
030203 arthritis & rheumatology ,Male ,medicine.medical_specialty ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Rheumatology ,Arthritis, Rheumatoid ,03 medical and health sciences ,0302 clinical medicine ,Methotrexate ,Adrenal Cortex Hormones ,Internal medicine ,Rheumatoid arthritis ,Antirheumatic Agents ,Ill-Housed Persons ,medicine ,Humans ,030212 general & internal medicine ,business ,Physical Therapy Modalities - Published
- 2018
21. Has Rheumatology Become a More Attractive Career Choice? Comparison of Trends in the Rheumatology Fellowship Match From 2008 to 2013 With Those From 2014 to 2017
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Lauren M Mathias, Huynh W. Tran, and Richard S. Panush
- Subjects
030203 arthritis & rheumatology ,medicine.medical_specialty ,Career Choice ,business.industry ,education ,Rheumatology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Family medicine ,Workforce ,medicine ,Humans ,Job satisfaction ,Salary ,Fellowships and Scholarships ,business ,Career choice ,Retrospective Studies - Abstract
Objective Rheumatology has previously been a less attractive career choice than other internal medicine (IM) subspecialties. Recent fellowship data from the National Resident Matching Program (NRMP) has suggested that this may have changed. Therefore, we evaluated the current attractiveness of rheumatology as a career choice and compared it with other medical subspecialties. Methods Data from the NRMP from 2008 to 2017, the 2015 American College of Rheumatology workforce study, and Medscape physician salaries from 2010 to 2017 were used to determine annual numbers of fellowship applicants, availability of positions, and post-fellowship salary trends. Data from 2008 to 2013 were compared with those from 2014 to 2017, and rheumatology was compared with other IM subspecialties. Results The total number of annual fellowship applicants to rheumatology for 2008-2013 decreased by 3% (average annual mean ± SEM percentage change of -1.9 ± 2.6%), from 251 to 244 applicants. However, for 2014-2017, annual rheumatology applications increased by 44% (average annual mean ± SEM percentage change of 20.7 ± 10.5% [P = 0.03]), from 230 to 332 applicants. Other nonprocedural and procedural IM subspecialties did not exhibit a similar increase. For rheumatology, the increases in the ratio of annual applicants to positions (P = 0.02) and in the percentage of US medical graduates applying (P = 0.03) were statistically significant, and mean post-fellowship salary also rose. Conclusion The aforementioned observations suggest that rheumatology has become a more attractive career choice since 2014. We speculate that the increasing popularity of the field is multifactorial, likely reflecting lifestyle, job satisfaction and availability, influence of mentors, and other elements. This salutary and exciting potential opportunity for rheumatology should be exploited.
- Published
- 2018
22. Has Rheumatology Become a More Attractive Career Choice? Comparison of Trends in the Rheumatology Fellowship Match From 2008 to 2013 With Those From 2014 to 2017
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Tran, Huynh W., primary, Mathias, Lauren M., additional, and Panush, Richard S., additional
- Published
- 2019
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23. The provision of written information and its effect on levels of pain and anxiety during electrodiagnostic studies: A randomised controlled trial
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Lai, YL, Van Heuven, A, Borire, A, Kandula, T, Colebatch, JG, Krishnan, AV, Huynh, W, Lai, YL, Van Heuven, A, Borire, A, Kandula, T, Colebatch, JG, Krishnan, AV, and Huynh, W
- Abstract
Objective The provision of written information is a low-cost and readily available intervention that has been found to reduce pain and anxiety in a variety of clinical settings. The current study was undertaken to determine if information provision may improve patients’ experience during conventional electrodiagnostic studies. Methods 128 participants were recruited from a tertiary teaching hospital who were referred for electrodiagnostic studies. They were randomized into 2 groups where the intervention group was provided with written information about the electrodiagnostic testing. Patients were invited to complete a questionnaire that included pain and anxiety using a visual analogue scale (VAS) following the testing. All participants underwent nerve conduction studies (NCS) whilst a subset also underwent subsequent needle electromyography (EMG). Results Those who received information had a statistically significant lower perception of anxiety during NCS, whilst only females who received information had a statistically significant lower perception of pain to both NCS and EMG. Conclusions The provision of written information can reduce the degree of pain and anxiety experienced during electrodiagnostic testing. Significance Improving patient comfort and tolerability during electrodiagnostic testing may have practical implications towards more reliable and accurate results obtained from such investigations that may in turn improve patient diagnosis and management.
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- 2018
24. Respiratory function and cognitive profile in amyotrophic lateral sclerosis.
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Huynh, W., Sharplin, L. E., Caga, J., Highton‐Williamson, E., and Kiernan, M. C.
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AMYOTROPHIC lateral sclerosis , *COGNITIVE ability , *BURDEN of care , *COGNITION disorders , *MINI-Mental State Examination - Abstract
Background and purpose: Amyotrophic lateral sclerosis (ALS) is increasingly recognized as a multisystem disorder with 30%–50% of patients exhibiting cognitive impairment. The pathophysiological mechanisms of cognitive dysfunction are probably multifactorial although hypoventilation secondary to respiratory dysfunction may contribute to cognitive decline. The current study aimed to identify the relationship between respiratory function in ALS patients and the presence and degree of cognitive impairment. Methods: Amyotrophic lateral sclerosis patients were prospectively recruited from a multidisciplinary ALS clinic. Baseline clinical assessments including respiratory function as assessed by spirometry were recorded with forced vital capacity (FVC) ≤ 75% considered to be reduced respiratory function. Cognitive testing was performed utilizing the Addenbrooke's Cognitive Examination (ACE) and the Mini‐Mental State Examination (MMSE). Results: From a cohort of 100 ALS patients, 48% were categorized as having impaired respiratory function (FVC = 58.24% ± 2.15%) whilst 52% had normal function (88.65% ± 1.27%). Compared to the group with normal respiratory function (ACE 90.68 ± 0.89, MMSE 28.22 ± 0.21), patients with respiratory dysfunction had significantly reduced cognitive function (ACE 86.83 ± 1.5, P = 0.025; MMSE 26.29 ± 0.45, P = 0.029). Furthermore, subscores demonstrated significant differences between the groups with respect to domains in memory (P = 0.003) and attention (P = 0.05) with a trend observed in fluency (P = 0.082). There was a significant correlation between patient baseline FVC and ACE scores as well as between FVC and memory and fluency subscores (P < 0.01). Conclusion: Amyotrophic lateral sclerosis patients with respiratory compromise were more likely to develop reduced cognitive function. In addition to improving physical function, it remains plausible that non‐invasive ventilation may alter the progression of cognitive impairment in ALS patients and potentially improve overall quality of life and carer burden. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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25. Immune dysregulation in patients with carpal tunnel syndrome
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Moalem-Taylor, G, Baharuddin, B, Bennett, B, Krishnan, AV, Huynh, W, Kiernan, MC, Shin-Yi Lin, C, Shulruf, B, Keoshkerian, E, Cameron, B, Lloyd, A, Moalem-Taylor, G, Baharuddin, B, Bennett, B, Krishnan, AV, Huynh, W, Kiernan, MC, Shin-Yi Lin, C, Shulruf, B, Keoshkerian, E, Cameron, B, and Lloyd, A
- Abstract
Peripheral immunity plays a key role in maintaining homeostasis and conferring crucial neuroprotective effects on the injured nervous system, while at the same time may contribute to increased vulnerability to neuropathic pain. Little is known about the reciprocal relationship between entrapment neuropathy and peripheral immunity. This study investigated immune profile in patients with carpal tunnel syndrome (CTS), the most prevalent entrapment neuropathy. All patients exhibited neurophysiological abnormalities in the median nerve, with the majority reporting neuropathic pain symptoms. We found a significant increase in serum CCL5, CXCL8, CXCL10 and VEGF, and in CD4+ central and effector memory T cells in CTS patients, as compared to healthy controls. CCL5 and VEGF were identified as having the highest power to discriminate between patients and controls. Interestingly, and contrary to the prevailing view of CCL5 as a pro-nociceptive factor, the level of circulating CCL5 was inversely correlated with neuropathic pain intensity and median nerve motor latency. In contrast, the level of central memory T cells was positively associated with abnormal neurophysiological findings. These results suggest that entrapment neuropathy is associated with adaptive changes in the homeostasis of memory T cells and an increase in systemic inflammatory modulating cytokines/chemokines, which potentially regulate neuropathic symptoms.
- Published
- 2017
26. Structure of a mechanotransduction ion channel Drosophila NOMPC in nanodisc
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Jin, P., primary, Bulkley, D., additional, Guo, Y., additional, Zhang, W., additional, Guo, Z., additional, Huynh, W., additional, Wu, S., additional, Meltzer, S., additional, Chen, T., additional, Jan, L.Y., additional, Jan, Y.-N., additional, and Cheng, Y., additional
- Published
- 2017
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27. Job performance and bonus
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Huynh, W., Cavalini, P (Thesis Advisor), Huynh, W., and Cavalini, P (Thesis Advisor)
- Abstract
The purpose of this research is to study the relationship between performance and bonuses and whether this relationship differs across gender and personality traits (extraversion and conscientiousness) of individuals. The study was conducted at a bank, 309 participants filled in an online questionnaire. As expected, results indicated that performance is positively related to the amount bonus. Employees who had higher performance received a higher bonus. There were no significant differences between relations of each performance measure (appraisal, manager’s opinion & self-opinion). We found a significant interaction effect of gender on the relationship between performance and bonus. However we did not find a significant interaction effect for both extraversion and conscientiousness. We can conclude that performance does predict bonus but that the effects are small. This information could be used to arouse further interest in researching what other factors influence bonus.
- Published
- 2016
28. Utility of maximum perfusion sity as an ultrasonographic marker of intraneural blood flow
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Borire, Aa, Visser, Lh, Padua, Luca, Colebatch, Jg, Huynh, W, Simon, Ng, Kiernan, Mc, Krishnan, Av, Padua, Luca (ORCID:0000-0003-2570-9326), Borire, Aa, Visser, Lh, Padua, Luca, Colebatch, Jg, Huynh, W, Simon, Ng, Kiernan, Mc, Krishnan, Av, and Padua, Luca (ORCID:0000-0003-2570-9326)
- Abstract
We quantified intraneural blood flow (INBF) using a perfusion measurement software (PixelFlux), and compared it to the qualitative method of counting blood vessels (vessel score) in a cohort of carpal tunnel syndrome (CTS) patients. METHODS: 47 patients (67 wrists) with clinical and electrophysiological diagnosis of CTS, and 20 healthy controls (40 wrists) were enrolled. Median nerve ultrasound (US) was performed at the carpal tunnel inlet to measure the cross-sectional area (CSA) and vessel score. Power Doppler sonograms from nerves with detectable INBF were processed with PixelFlux, to obtain the maximum perfusion intensity (MPI). RESULTS: Forty-nine percent of CTS patients had detectable INBF compared to none in the control group (P<0.0001). MPI correlated significantly with vessel score (r=0.945, P<0.0001), CSA (r=0.613, P<0.0001), and electrophysiological severity (r=0.440, P<0.0001). MPI had higher intra/inter-observer reliability compared to vessel score (0.95 vs 0.47). CONCLUSION: MPI is a better method for quantification of INBF.
- Published
- 2016
29. Ion Channel Modulation as a Therapeutic Approach in Multiple Sclerosis
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Arnold, R., primary, Huynh, W., additional, Kiernan, M.C., additional, and Krishnan, A.V., additional
- Published
- 2015
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30. Potassium and nitrogen poising: Physiological changes and biomass gains in rice and barley
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Britto, D. T., primary, Balkos, K. D., additional, Becker, A., additional, Coskun, D., additional, Huynh, W. Q., additional, and Kronzucker, H. J., additional
- Published
- 2014
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31. Factors influencing recent dental graduates' location and sector of employment in Victoria
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Silva, M., primary, Phung, K., additional, Huynh, W., additional, Wong, H., additional, Lu, J., additional, Aijaz, A., additional, and Hopcraft, M., additional
- Published
- 2006
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32. Nanocrystal/Polymer Composite Photovoltaic Devices
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Huynh, W., primary, Manna, L., additional, and Alivisatos, A. P., additional
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- 2000
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33. Near-field optical spectroscopy of individual surface-plasmon modes in colloid clusters
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Markel, V. A., primary, Shalaev, V. M., additional, Zhang, P., additional, Huynh, W., additional, Tay, L., additional, Haslett, T. L., additional, and Moskovits, M., additional
- Published
- 1999
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34. Meningococcal meningitis and a negative cerebrospinal fluid: case report and its medicolegal implications.
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Huynh W, Lahoria R, Beran RG, and Cordato D
- Published
- 2007
35. Dimetal Linked Open Frameworks: [(CH<INF>3</INF>)<INF>4</INF>N]<INF>2</INF>(Ag<INF>2</INF>,Cu<INF>2</INF>)Ge<INF>4</INF>S<INF>10</INF>
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Bowes, C. L., Huynh, W. U., Kirkby, S. J., Malek, A., Ozin, G. A., Petrov, S., Twardowski, M., Young, D., Bedard, R. L., and Broach, R.
- Abstract
Synthetic and X-ray structural details, optical and vibrational spectroscopic, and thermal properties of the materials [(CH
3 )4 N]2 M2 Ge4 S10 (where M = Cu, Ag), are described for the first time. Rietveld PXRD full-profile structure refinements of [(CH3 )4 N]2 M2 Ge4 S10 reveal a novel open-framework architecture in which dimetal M2 2+ and adamantanoid Ge4 S10 4- building blocks are alternately substituted into the tetrahedral Zn2+ and S2- sites of a zinc blende lattice, all linked together by [Ge(μ-S)]2 M−M[(μ-S)Ge]2 metal−metal bonded bridging units. The metal−metal distances in the S2 M−MS2 twisted I dihedral unit are 2.761 Å (Ag) and 2.409 Å (Cu). These internuclear separations are shorter than the bulk metals themselves (2.89 Å, Ag; 2.54 Å, Cu). This implies that the adamantanoid Ge4 S10 4--based open-framework structure is held together by d10−d10 M+−M+ metal−metal bonds. FT-Raman provides a direct probe of this interaction. Dimetal-framework breathing vibrational modes are observed around 38 cm-1 for M = Ag and 55 cm-1 for M = Cu. In situ VT-PXRD analysis demonstrates that [(CH3 )4 N]2 Ag2 Ge4 S10 retains its structural integrity upon exposure to air after in vacuo heating above the [(CH3 )4 N]+ loss temperature. It seems likely that the disilver connection of adamantanoid Ge4 S10 4- building blocks confers thermal stability upon the framework.- Published
- 1996
36. Critical care admission following elective surgery was not associated with survival benefit
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Kahan, Brennan C., Desponia, Koulenti, Kostoula, Arvaniti, Vanessa, Beavis, Douglas, Campbell, Matthew, Chan, Rui, Moreno, Pearse, Rupert M., Scott, Beattie, Pierre-Alain, Clavien, Nicolas, Demartines, Lee, A Fleisher, Mike, Grocott, James, Haddow, Andreas, Hoeft, Peter, Holt, Naomi, Pritchard, Andrew, Rhodes, Duminda, Wijeysundera, Matt, Wilson, Tahania, Ahmed, Kirsty, Everingham, Russell, Hewson, Marta, Januszewska, Rupert, M Pearse, Mandeep-Kaur, Phull, Richard, Halliwell, Mark, Shulman, Paul, Myles, Werner, Schmid, Michael, Hiesmayr, Patrick, Wouters, Stefan de Hert, Suzana, Lobo, Xiangming, Fang, Lars, Rasmussen, Emmanuel, Futier, Matthieu, Biais, Aurélien, Venara, Karem, Slim, Michael, Sander, Despoina, Koulenti, Mathew, Chan, Atul, Kulkarni, Susilo, Chandra, Aida, Tantri, Emad, Geddoa, Muntadhar, Abbas, Giorgio Della Rocca, Datin, Sivasakthi, Marzida, Mansor, Pastor, Luna, Arthur, Bouwman, Wolfgang, Buhre, Tim, Short, Tunde, Osinaike, Ricardo, Matos, Ioana, Grigoras, Mikhail, Kirov, Denis, Protsenko, Bruce, Biccard, Cesar, Aldecoa, Michelle, Chew, Christoph, Hofer, Martin, Hubner, James, Ditai, Tamas, Szakmany, Lee, Fleisher, Marissa, Ferguson, Michael, Macmahon, Ritchie, Cherian, Helen, Currow, Kathirgamanathan, Kanathiban, David, Gillespie, Edward, Pathmanathan, Katherine, Phillips, Jenifer, Reynolds, Joanne, Rowley, Jeanene, Douglas, Ross, Kerridge, Sameer, Garg, Michael, Bennett, Megha, Jain, David, Alcock, Nico, Terblanche, Rochelle, Cotter, Kate, Leslie, Marcelle, Stewart, Nicolette, Zingerle, Antony, Clyde, Oliver, Hambidge, Adam, Rehak, Sharon, Cotterell, Wilson Binh Quan Huynh, Timothy, Mcculloch, Erez, Ben-Menachem, Thomas, Egan, Jennifer, Cope, Paul, Fellinger, Simone, Haselberger, Caroline, Holaubek, Paul, Lichtenegger, Florian, Scherz, Franz, Hoffer, Veronika, Cakova, Andreas, Eichwalder, Norbert, Fischbach, Reinhold, Klug, Elisabeth, Schneider, Martin, Vesely, Reinhart, Wickenhauser, Karl Gernot Grubmueller, Marion, Leitgeb, Friedrich, Lang, Nancy, Toro, Marlene, Bauer, Friedrich, Laengle, Thomas, Mayrhofer, Christian, Buerkle, Karin, Forstner, Reinhard, Germann, Harald, Rinoesl, Elke, Schindler, Ernst, Trampitsch, Gerhard, Fritsch, Christian, Szabo, Jawad, Bidgoli, Hans, Verdoodt, Patrice, Forget, David, Kahn, Fernande, Lois, Mona, Momeni, Caroline, Prégardien, Audrey, Pospiech, Arnaud, Steyaert, Laurent, Veevaete, Dirk De Kegel, Karen De Jongh, Luc, Foubert, Carine, Smitz, Marcel, Vercauteren, Jan, Poelaert, Veerle Van Mossevelde, Jacques, Abeloos, Stefaan, Bouchez, Marc, Coppens, Luc De Baerdemaeker, Isabel, Deblaere, Ann De Bruyne, Stefan De Hert, Kristine, Fonck, Bjorn, Heyse, Tom, Jacobs, Koen, Lapage, Anneliese, Moerman, Martine, Neckebroek, Aliaksandra, Parashchanka, Nathalie, Roels, Nancy Van Den Eynde, Michael, Vandenheuvel, Jurgen Van Limmen, Ann, Vanluchene, Caroline, Vanpeteghem, Piet, Wyffels, Christel, Huygens, Punitha, Vandenbempt, Marc Van de Velde, Dimitri, Dylst, Bruno, Janssen, Evelien, Schreurs, Fábia Berganton Aleixo, Keulle, Candido, Hugo Dias Batista, Mario, Guimarães, Jaqueline, Guizeline, João, Hoffmann, Suzana, M Lobo, Francisco Ricardo Lobo, Vinícius, Nascimento, Katia, Nishiyama, Lucas, Pazetto, Daniela, Souza, Rodrigo Souza Rodrigues, Ana Maria Vilela Dos Santos, Jaquelline, Jardim, Joao, Silva, Paulo do Nascimento Junior, Thalissa Hermínia Baio, Gabriel Isaac Pereira de Castro, Henri Roger Watanabe Oliveira, Cristina Prata Amendola, Gutemberg, Cardoso, Daniela, Ortega, Ana Flavia Brotto, Mirella Cristine De Oliveira, Álvaro, Réa-Neto, Fernando, Dias, Pedro, Azambuja, Marcos Freitas Knibel, Antonio, Martins, William, Almeida, Calim Neder Neto, Maria Angela Tardelli, Eliana, Caser, Marcio, Machado, Crisitiano, Aguzzoli, Sérgio, Baldisserotto, Fernanda Beck Tabajara, Fernanda, Bettega, La Hore Correa Rodrigues Júnior, Julia de Gasperi, Lais, Faina, Marcos Farias Nolasco, Bruna Ferreira da Costa Fischer, Mariana Fosch de Campos Ferreira, Cristina, Hartmann, Marta, Kliemann, Gustavo Luis Hubert Ribeiro, Julia Merladete Fraga, Thiago Motta Netto, Laura Valduga Pozza, Paulo Rafael Wendling, Caroline, Azevedo, Juliana, Garcia, Marcel, Lopes, Bernardo, Maia, Paula, Maselli, Ralph, Melo, Weslley, Mendes, Matheus, Neves, Jacqueline, Ney, Claudio, Piras, Christopher, Applewhaite, Adrienne, Carr, Lorraine, Chow, Kaylene, Duttchen, Julena, Foglia, Michael, Greene, Ashley, Hinther, Kendra, Houston, Thomas Jared McCormick, Jennifer, Mikhayel, Sam, Montasser, Alex, Ragan, Andrew, Suen, Adrianna, Woolsey, Hai Chuan Yu, Duane, Funk, Stephen, Kowalski, Regina, Legaspi, Heather, Mcdonald, Faisal, Siddiqui, Jeremy, Pridham, Bernadette, Rowe, Sonia, Sampson, Barton, Thiessen, Geoff, Zbitnew, Andre, Bernard, Ronald, George, Philip, Jones, Rita, Moor, Naveed, Siddiqui, Alexandra, Wolfer, Diem, Tran, Denyse, Winch, Gary, Dobson, Thomas, Mccormick, Osama, Montasser, Richard, Hall, Leyla, Baghirzada, Si Yuan Dai, Gregory, Hare, Esther, Lee, Uma, Shastri, Albert, Tsui, Anmol, Yagnik, Danielle, Alvares, Stephen, Choi, Heather, Dwyer, Kathrina, Flores, Colin, Mccartney, Priya, Somascanthan, Carroll, Jo, Janneth, Pazmino-Canizares, Noam, Ami, Vincent, Chan, Anahi, Perlas, Ruth, Argue, Katie, Lavis, Kelly, Mayson, Ying, Cao, Hong, Gao, Tingju, Hu, Jie, Lv, Jian, Yang, Yang, Yang, Zhong, Yi, Jing, Zhou, Xiaohua, Zou, Miao, He, Xiaoying, Li, Dihuan, Luo, Haiying, Wang, Tian, Yu, Liyong, Chen, Lijun, Wang, Yunfei, Cai, Zhongming, Cao, Yanling, Li, Jiaxin, Lian, Haiyun, Sun, Sheng, Wang, Zhipeng, Wang, Kenru, Wang, Zhu, Yi, Xindan, Du, Hao, Fan, Yunbin, Fu, Lixia, Huang, Yanming, Huang, Haifang, Hwan, Hong, Luo, Pi-Sheng, Qu, Fan, Tao, Zhen, Wang, Guoxiang, Wang, Shun, Wang, Yan, Zhang, Xiaolin, Zhang, Chao, Chen, Weixing, Wang, Zhengyuan, Liu, Lihua, Fan, Jing, Tang, Yijun, Chen, Yongjie, Chen, Yangyang, Han, Changshun, Huang, Guojin, Liang, Jing, Shen, Jun, Wang, Qiuhong, Yang, Jungang, Zhen, Haidong, Zhou, Junping, Chen, Zhang, Chen, Xiaoyu, Li, Meng, Bo, Haiwang, Ye, Xiaoyan, Zhang, Yanbing, Bi, Jianqiao, Cao, Fengying, Guo, Hong, Lin, Yang, Liu, Meng, Lv, Pengcai, Shi, Xiumei, Song, Chuanyu, Sun, Yongtao, Sun, Yuelan, Wang, Shenhui, Wang, Min, Zhang, Rong, Chen, Jiabao, Hou, Yan, Leng, Qing-Tao, Meng, Qian, Li, Zi-Ying, Shen, Zhong-Yuan, Xia, Rui, Xue, Yuan, Zhang, Zhao, Bo, Xian-Jin, Zhou, Qiang, Chen, Huinan, Guo, Yongqing, Guo, Yuehong, Qi, Zhi, Wang, Jianfeng, Wei, Weiwei, Zhang, Lina, Zheng, Bao, Qi, Yaqiu, Chen, Yijiao, Chen, Yue, Fei, Nianqiang, Hu, Xuming, Hu, Min, Lei, Xiaoqin, Li, Xiaocui, Lv, Fangfang, Miao, Lingling, Ouyang, Qian, Lu, Conyu, Shen, Sun, Yu, Yuting, Wang, Dong, Wang, Chao, Wu, Liyuan, Xu, Jiaqi, Yuan, Lina, Zhang, Huan, Zhang, Yapping, Zhang, Jinning, Zhao, Chong, Zhao, Lei, Zhao, Tianzhao, Zheng, Dachun, Zhou, Haiyan, Zhou, Zhou, Ce, Kaizhi, Lu, Ting, Zhao, Changlin, He, Hong, Chen, Shasha, Chen, Baoli, Cheng, Jie, He, Lin, Jin, Caixia, Li, Hui, Li, Yuanming, Pan, Yugang, Shi, Xiao Hong Wen, Shuijing, Wu, 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Bhavika, Daya, Leanne, Drummond, Ali, Elabib, Ehab Helmy Abdel Goad, Ismail, E Goga, Riaz, Goga, Harrichandparsad, R, Richard, E Hodgson, Jordaan, J, Nicky, Kalafatis, Christian, Kampik, T Landers, A, Emil, Loots, Rajhmum, Madansein, Anil, Madaree, Thandinkosi, E Madiba, Vukani, T Manzini, Mbali, Mbuyisa, Rajan, Moodley, Mduduzi, Msomi, Innocent, Mukama, Desigan, Naidoo, Rubeshan, Naidoo, Tesuven, K Naidu, Sindiswa, Ntloko, Eneshia, Padayachee, Lucelle, Padayachee, Martijn, Phaff, Bala, Pillay, Desigan, Pillay, Lutchmee, Pillay, Anupa, Ramnarain, Suren, R Ramphal, Paul, Ryan, Ahmed, Saloojee, Motshedisi, Sebitloane, Noluyolo, Sigcu, Jenna, L Taylor, Alexandra, Torborg, Linda, Visser, Philip, Anderson, Alae, Conradie, Mathew de Swardt, Martin de Villiers, Johan, Eikman, Riaan, Liebenberg, Johan, Mouton, Abbey, Paton, Louwrence van der Merwe, Candice, Wilscott-Davids, Wendy Joan Barrett, Marlet, Bester, Johan de Beer, Jacques, Geldenhuys, Hanni, Gouws, Jan-Hendrik, Potgieter, Magdel, Strydom, Edwin, Wilberforce-Turton, Rubendraj, R Chetty, Subash, Chirkut, Larissa, Cronje, Kim de Vasconcellos, Nokukhanya, Z Dube, N Sibusiso Gama, Garyth, M Green, Randolph, Green-Thompson, Suman Mewa Kinoo, Prenolin, Kistnasami, Kapil, Maharaj, Manogaran, S Moodley, Sibongile, J Mothae, Ruvashni, Naidoo, Aslam, M, Noorbhai, F, Vivesh, Rughubar, Jenendhiran, Reddy, Avesh, Singh, David, L Skinner, Murray, J Smith, Bhagwan, Singh, Ravi, Misra, Maheshwar, Naidoo, Pireshin, Ramdharee, Yvonne, Selibea, Selina, Sewpersad, Shailendra, Sham, Joseph, D Wessels, Cucu, Africander, Tarek, Bejia, Stephen, P Blakemore, Marisa, Botes, Bimalshakth, Bunwarie, Carlos, B Hernandez, Mohammud, A Jeeraz, Dagmara, A Legutko, Acela, G Lopez, Jenine, N De Meyer, Tanaka, Muzenda, Noel, Naidoo, Maryam, Patel, Rao, Pentela, Marina, Junge, Naj, Mansoor, Lana, Rademan, Pawel, Scislowski, Ismail, Seedat, Bianca van den Berg, Doreen van der Merwe, Steyn van Wyk, Komalan, Govender, Darshan, Naicker, Rajesh, Ramjee, Mueen, Saley, Warren Paul Kuhn, Roel, Matos-Puig, Zaheer, Moolla, Alberto, Lisi, Gisela, Perez, Anna Valle Beltran, Angels, Lozano, Carlos Delgado Navarro, Alejandro, Duca, Ernesto Pastor Martinez, Carlos, Ferrando, Isabel, Fuentes, Maria Luisa García-Pérez, Estefania, Gracia, Ana Izquierdo Palomares, Antonio, Katime, Amanda, Miñana, Raul, Incertis, Esther, Romero, Carolina Soledad Romero Garcia, Concepcion, Rubio, Tania Socorro Artiles, Marina, Soro, Paola, Valls, Gisela Alaman Laguarda, Pau, Benavent, Vicente Chisbert Cuenca, Andreu, Cueva, Matilde, Lafuente, Asuncion Marques Parra, Alejandra Romero Rodrigo, Silvia, Sanchez-Morcillo, Sergi, Tormo, Francisco Javier Redondo, Jose De Andres, Lorena Gómez Diago, Maria José Hernández Cádiz, Granell Gil Manuel, Raquel, Peris, Cristina, Saiz, Jose, Tatay, Maria Teresa Tebar Soto, Tamara, Brunete, David, Cancho, David, R Delgado García, Diana, Zamudio, Santiago Garcia Del Valle, M Luz Serrano, Eduardo, Alonso, Victor, Anillo, Emilio, Maseda, Patricia, Salgado, Luis, Suarez, Alejandro, Suarez-de-la-Rica, María José Villagrán, José Ignacio Alonso, Estefania, Cabezuelo, Irene, Garcia-Saiz, Olga Lopez Del Moral, Silvia, Martín, Alba Perez Gonzalez, Sherezade Tovar Doncel, Martin Agüero Vera, Francisco José Ávila Sánchez, Beatriz, Castaño, Beatriz Castaño Moreira, Sahely Flores Risco, Daniel Paz Martín, Fernando Pérez Martín, Paloma, Poza, Adela, Ruiz, Wilson Fabio Serna Martínez, Bárbara Vázquez Vicente, Saul Velaz Dominguez, Salvador, Fernández, Alfonso, Munoz-López, Maria Jose Bernat, Arantxa, Mas, Kenneth, Planas, Monir, Jawad, Yousif, Saeed, Annika, Hedin, Helena, Levander, Sandra, Holmström, David, Lönn, Frank, Zoerner, Irene, Åkring, Carl, Widmark, Jan, Zettergren, Victor Aspelund Liljequist, Lena, Nystrom, Suzanne, Odeberg-Wernerman, Anders, Oldner, Patrik, Reje, Sara, Lyckner, Jesper, Sperber, Anne, Adolfsson, Bengt, Klarin, Katrin, Ögren, Jean-Pierre, Barras, Thomas, Bührer, Vasileios, Despotidis, Naeder, Helmy, Stephan, Holliger, Dimitri Aristotle Raptis, Roger, Schmid, Antoine, Meyer, Yves, Jaquet, Ulf, Kessler, Mirza, Muradbegovic, Solange, R Nahum, Teresa, Rotunno, Boris, Schiltz, François, Voruz, Marc, Worreth, Dimitri, Christoforidis, Sotirios Georgios Popeskou, Markus, Furrer, Gian Andrea Prevost, Andrea, Stocker, Klaus, Lang, Stefan, Breitenstein, Michael, T Ganter, Martin, Geisen, Christopher, Soll, Michelle, Korkmaz, Iris, Lubach, Michael, Schmitz, Moritz Meyer Zu Schwabedissen, Urs, Zingg, Thomas, Hillermann, Stefan, Wildi, Bernardo Bollen Pinto, Bernhard, Walder, Martin, Hübner, Giustina, Mariotti, Ksenija, Slankamenac, Mirioce, Namuyuga, Edward, Kyomugisha, Olivia, Kituuka, Anne Wesonga Shikanda, Nasser, Kakembo, Charles Otim Tom, Antonina, Webombesa, Emmanuel, Bua, Eden Michael Ssettabi, Joseph, Epodoi, Fiona, Kabagenyi, Fred, Kirya, Ged, Dempsey, Colette, Seasman, Raja Basit Nawaz Khan, Claire, Kurasz, Mark, Macgregor, Burhan, Shawki, Vimal, Hariharan, Simon, Chau, Kate, Ellis, 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Woon, Yuan Liang, Abd Hadi, Husni Zaeem, Ahmad Azam, Ummi Azmira, Alias, Abdul Hafiz, Kesut, Saiful Aizar, Lee, Jun May, Ooi, Dar Vin, Sulaiman, Hetty Ayuni, Tengku Lih, Tengku Alini, Veerakumaran, Jeyaganesh, Rojas, Eder, Resendiz, Gerardo Esteban Alvarez, Zapata, Darcy Danitza Mari, Aguilar López, Julio Cesar Jesú, Flores, Armando Adolfo Alvarez, Amador, Juan Carlosc Bravo, Avila, Erendira Jocelin Dominguez, Aquino, Laura Patricia González, Rodriguez, Ricardo Lopez, Landa, Mariana Torre, Urias, Emma, Hollmann, Marku, Hulst, Abraham, Kirzner, Osne, Preckel, Benedikt, Koopman-van Gemert, Ankie, Buise, Marc, Tolenaar, Noortje, Weber, Eric, de Fretes, Jennifer, Houweling, Peter, Ormskerk, Patricia, Van Bommel, Jasper, Lance, Marcu, Smit-Fun, Valerie, van Zundert, Tom, Baas, Peter, de Boer, Hans Donald, Sprakel, Joost, Elferink-Vonk, Renske, Noordzij, Peter, van Zeggeren, Laura, Brand, Bastiaan, spanjersberg, Rob, ten Bokkel-Andela, Janneke, Numan, Janneke, van Klei, Wilton, van Zaane, 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Sarki, Adamu Muhammad, Adekola, Oyebola, Akanmu, Olanrewaju, Durodola, Akanmu, Olukoju, Olusegun, Raji, Victor, Olajumoke, Tokunbo, Oyebamiji, Emmanuel, Adenekan, Anthony, Adetoye, Adenekan, Faponle, Folayemi, Olateju, Simeon, Owojuyigbe, Afolabi, Talabi, Ademola, Adenike, Odewabi, Adewale, Badru, Collins, Nwokoro, Ezekiel, Emmanuel, Fatungase, Oluwabunmi Motunrayo, Grace, Anuforo, Sola, Sotannde, Stella, Ogunmuyiwa, Ademola, Adeyinka, Adeolu, Augustine A., Adigun, Tinuolac, Akinwale, Mukaila, Fasina, Oluyemi, Gbolahan, Olalere, Idowu, Olusola, Olonisakin, Rotimi Peter, Osinaike, Babatunde Babasola, Asudo, Felicia, Mshelia, Danladi, Abdur-Rahman, Lukman, Agodirin, Olayide, Bello, Jibril, Bolaji, Benjamin, Oyedepo, Olanrewaju Olubukola, Ezike, Humphrey, Iloabachie, Ikechukwu, Okonkwo, Ikemefuna, Onuora, Elia, Onyeka, Tonia, Ugwu, Innocent, Umeh, Friday, Alagbe-Briggs, Olubusola, Dodiyi-Manuel, Amabra, Echem, Richard, Obasuyi, Bright, Onajin-Obembe, Bisola, Bandeira, Maria Expedito, Martins, Alda, Tomé, Miguel, Martins Costa, Ana Cristina Miranda, Krystopchuk, Andriy, Branco, Teresa, Esteves, Simao, Melo, Marco António, Monte, Júlia, Rua, Fernando, Martins, Isabel, Pinho-Oliveira, Vítor Miguel, Rodrigues, Carla Maria, Cabral, Raquel, Marques, Sofia, Rêgo, Sara, Teixeira Jesus, Joana Sofia, Conceição Marques, Maria, Romao, Cristina, Dias, Sandra, Santos, Ana Margarida, Alves, Maria Joao, Salta, Cristina, Cruz, Salome, Duarte, Célia, Furtado Paiva, António Armando, do Nascimento Cabral, Tiago, Fariae Maia, Dionisio, Correia da Silva, Rui Freitas Mendonça, Langner, Anuschka, Oliveira Resendes, Hernâni, da Conceição Soares, Maria, Abrunhosa, Alexandra, Faria, Filomena, Miranda, Lina, Pereira, Helena, Serra, Sofia, Ionescu, Daniela, Margarit, Simona, Mitre, Calin, Vasian, Horatiu, Manga, Gratiela, Stefan, Andreea, Tomescu, Dana, Filipescu, Daniela, Paunescu, Marilena-Alina, Stefan, Mihai, Stoica, Radu, Gavril, Laura, Pătrăşcanu, Emilia, Ristescu, Irina, Rusu, Daniel, Diaconescu, Ciresica, Iosep, Gabriel Florin, Pulbere, Dorin, Ursu, Irina, Balanescu, Andreea, Grintescu, Ioana, Mirea, Liliana, Rentea, Irina, Vartic, Mihaela, Lupu, Mary-Nicoleta, Stanescu, Dorin, Streanga, Lavinea, Antal, Oana, Hagau, Natalia, Patras, Dumitru, Petrisor, Cristina, Tosa, Flaviu, Tranca, Sebastian, Copotoiu, Sanda Maria, Ungureanu, Liviu Lucian, Harsan, Cristian Remu, Papurica, Mariu, Cernea, Daniela Denisa, Dragoescu, Nicoleta Alice, Aflori, Laura, Vaida, Carmen, Ciobotaru, Oana Roxana, Aignatoaie, Mariana, Carp, Cristina Paula, Cobzaru, Isabelle, Mardare, Oana, Purcarin, Bianca, Tutunaru, Valentin, Ionita, Victor, Arustei, Mirela, Codita, Anisoara, Busuioc, Mihai, Chilinciuc, Ion, Ciobanu, Cristina, Belciu, Ioana, Tincu, Eugen, Blaj, Mihaela, Grosu, Ramona-Mihaela, Sandu, Gigel, Bruma, Dana, Corneci, Dan, Dutu, Madalina, Krepil, Adriana, Copaciu, Elena, Dumitrascu, Clementina Oana, Jemna, Ramona, Mihaescu, Florentina, Petre, Raluca, Tudor, Cristina, Ursache, Elena, Kulikov, Alexander, Lubnin, Andrey, Grigoryev, Evgeny, Pugachev, Stanislav, Tolmasov, Alexander, Hussain, Ayyaz, Ilyina, Yana, Roshchina, Anna, Iurin, Aleksandr, Chazova, Elena, Dunay, Artem, Karelov, Alexey, Khvedelidze, Irina, Voldaeva, Olga, Belskiy, Vladislav, Dzhamullaev, Parvin, Grishkowez, Elena, Kretov, Vladimir, Levin, Valeriy, Molkov, Aleksandr, Puzanov, Sergey, Samoilenko, Aleksandr, Tchekulaev, Aleksandr, Tulupova, Valentina, Utkin, Ivan, Allorto, Nikki Leigh, Bishop, David Gray, Builu, Pierre Monji, Cairns, Carel, Dasrath, Ashish, de Wet, Jacque, den Hoedt, Marielle, Grey, Ben, Hayes, Morgan Philip, Küsel, Belinda Senta, Shangase, Nomcebo, Wise, Robert, Cacala, Sharon, Farina, Zane, Govindasamy, Vishendran, Kruse, Carl-Heinz, Lee, Carolyn, Marais, Leonard, Naidoo, Thinagrin Dhasarthun, Rajah, Chantal, Rodseth, Reitze Nil, Ryan, Lisa, von Rhaden, Richard, Adam, Suwayba, Alphonsus, Christella, Ameer, Yusuf, Anderson, Frank, Basanth, Sujith, Bechan, Sudha, Bhula, Chettan, 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Delgado García, David R., Zamudio, Diana, Garcia Del Valle, Santiago, Luz Serrano, M., Alonso, Eduardo, Anillo, Victor, Maseda, Emilio, Salgado, Patricia, Suarez, Lui, Suarez-de-la-Rica, Alejandro, Villagrán, María José, Alonso, José Ignacio, Cabezuelo, Estefania, Garcia-Saiz, Irene, Lopez del Moral, Olga, Martín, Silvia, Perez Gonzalez, Alba, Tovar Doncel, Sherezade, Vera, Martin Agüero, Ávila Sánchez, Francisco José, Castaño, Beatriz, Castaño Moreira, Beatriz, Flores Risco, Sahely, Paz Martín, Daniel, Pérez Martín, Fernando, Poza, Paloma, Ruiz, Adela, Serna Martínez, Wilson Fabio, Vicente, Bárbara Vázquez, Dominguez, Saul Velaz, Fernández, Salvador, Munoz-López, Alfonso, Bernat, Maria Jose, Mas, Arantxa, Planas, Kenneth, Jawad, Monir, Saeed, Yousif, Hedin, Annika, Levander, Helena, Holmström, Sandra, Lönn, David, Zoerner, Frank, Åkring, Irene, Widmark, Carl, Zettergren, Jan, Liljequist, Victor Aspelund, Nystrom, Lena, Odeberg-Wernerman, Suzanne, Oldner, Ander, Reje, Patrik, Lyckner, 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Bottrill, Fiona, Ramalingam, Ganesh, Webb, Stephen, Akerman, Nik, Antill, Philip, Bourner, Lynsey, Buckley, Sarah, Castle, Gail, Charles, Rob, Eggleston, Christopher, Foster, Rebecca, Gill, Satwant, Lindley, Kate, Lklouk, Mohamed, Lowery, Tracey, Martin, Oliver, Milne, David, O’Connor, Patrick, Ratcliffe, Andrew, Rose, Alastair, Smith, Annie, Varma, Sandeep, Ward, Jackie, Barcraft-Barnes, Helena, Camsooksai, Julie, Colvin, Carolyn, Reschreiter, Henrik, Tbaily, Lee, Venner, Nicola, Hamilton, Caroline, Kelly, Lewi, Toth-Tarsoly, Piroska, Dodsworth, Kerry, Foord, Denise, Gordon, Paul, Hawes, Elizabeth, Lamb, Nikki, Mouland, Johanna, Nightingale, Jeremy, Rose, Steve, Schrieber, Joe, Al ‘Amri, Khalid, Aladin, Hafiz, Arshad, Mohammed Asif, Barraclough, Jame, Bentley, Conor, Bergin, Colin, Carrera, Ronald, Clarkson, Aisling, Collins, Michelle, Cooper, Lauren, Denham, Samuel, Griffiths, Ewen, Ip, Peter, Jeyanthan, Somasundaram, Joory, Kavita, Kaur, Satwant, Marriott, Paul, Mitchell, Natalie, Nagaiah, Sukumar, Nilsson, Annette, Parekh, Nilesh, Pope, Martin, Seager, Joseph, Serag, Hosam, Tameem, Alifia, Thomas, Anna, Thunder, Joanne, Torrance, Andrew, Vohra, Ravinder, whitehouse, Arlo, Wong, Tony, Blunt, Mark, Wong, Kate, Giles, Julian, Reed, Isabelle, Weller, Debbie, Bell, Gillian, Birch, Julie, Damant, Rose, Maiden, Jane, Mewies, Clare, Prince, Claire, Radford, Jane, Balain, Birender, Banerjee, Robin, Barnett, Andrew, Burston, Ben, Davies, Kirsty, Edwards, Jayne, Evans, Chri, Ford, David, Gallacher, Pete, Hill, Simon, Jaffray, David, Karlakki, Sudheer, Kelly, Cormac, Kennedy, Julia, Kiely, Nigel, Lewthwaite, Simon, Marquis, Chri, Ockendon, Matthew, Phillips, Stephen, Pickard, Simon, Richardson, Jame, Roach, Richard, Smith, Tony, Spencer-Jones, Richard, Steele, Niall, Steen, Julie, Van Liefland, Marck, White, Steve, Faulds, Matthew, Harris, Meredyth, Kelly, Carrie, Nicol, Scott, Pearson, Sally Anne, Chukkambotla, Srikanth, Andrew, Alyson, Attrill, Elizabeth, Campbell, Graham, Datson, Amanda, Fouracres, Anna, Graterol, Juan, Graves, Lynne, Hong, Bosun, Ishimaru, Alexander, Karthikeyan, Arvind, King, Helen, Lawson, Tom, Lee, Gregory, Lyons, Saoirse, Macalister Hall, Andrew, Mathoulin, Sophie, Mcintyre, Eilidh, Mclaughlin, Danny, Mulcahy, Kathleen, Ratcliffe, Anna, Robbins, Jame, Sung, Weilin, Tayo, Adeoluwa, Trembath, Lisa, Venugopal, Suneetha, Walker, Robert, Wigmore, Geoffrey, Boereboom, Catherine, Downes, Charlotte, Humphries, Ryan, Melbourne, Susan, Smith, Coral, Tou, Samson, Ullah, Shafa, Batchelor, Nick, Boxall, Leigh, Broomby, Rupert, Deen, Tariq, Hellewell, Alistair, Helliwell, Laurence, Hutchings, Melanie, Hutchins, David, Keenan, Samantha, Mackie, Donna, Donna, Alison, Smith, France, Stone, Lucy, Thorpe, Kevin, Wassall, Richard, Woodgate, Andrew, Baillie, Shelley, Campbell, Tara, James, Sarah, King, Chri, Marques de Araujo, Daniela, Martin, Daniel, Morkane, Clare, Neely, Julia, Rajendram, Rajkumar, Burton, Megan, James, Kathryn, Keevil, Edward, Minik, Orsolya, Morgan, Jenna, Musgrave, Anna, Rajanna, Harish, Roberts, Tracey, Adamson, Michael, Jumbe, Sandra, Kendall, Jennie, Muthuswamy, Mohan Babu, Anderson, Charlotte, Cruikshanks, Andrew, Wrench, Ian, Zeidan, Lisa, Ardern, Diane, Harris, Benjamin, Hellstrom, Johanna, Martin, Jane, Thomas, Richard, Varsani, Nimu, Wrey Brown, Caroline, Docherty, Philip, Gillies, Michael, McGregor, Euan, Usher, Helen, Craig, Jayne, Smith, Andrew, Ahmad, Tahania, Bodger, Phoebe, Creary, Thai, Fowler, Alexander, Hewson, Ru, Ijuo, Eke, Jones, Timothy, Kantsedikas, Ilya, Lahiri, Sumitra, McLean, Aaron Lawson, Niebrzegowska, Edyta, Phull, Mandeep, Wang, Difei, Wickboldt, Nadine, Baldwin, Jacqueline, Doyle, Donna, Mcmullan, Sean, Oladapo, Michelle, Owen, Thoma, Williams, Alexandra, Daniel, Hull, Gregory, Peter, Husain, Tauqeer, Kirk-Bayley, Justin, Mathers, Edward, Montague, Laura, White, Stuart, Avis, Joanne, Cook, Tim, Dali-Kemmery, Lola, Kerslake, Ian, Lambourne, Victoria, Pearson, Annabel, Boyd, Christine, Callaghan, Mark, Lawson, Cathy, McCrossan, Roopa, Nesbitt, Vanessa, O’connor, Laura, Scott, Julia, Sinclair, Rhona, Farid, Nahla, Morgese, Ciro, Bhatia, Kailash, Karmarkar, Swati, Ahmed, Jamil, Branagan, Graham, Hutton, Monica, Swain, Andrew, Brookes, Jamie, Cornell, Jonathan, Dolan, Rachael, Hulme, Jonathan, Jansen van Vuuren, Amanda, Jowitt, Tom, Kalashetty, Gunasheela, Lloyd, Fran, Patel, Kiran, Sherwood, Nichola, Brown, Lynne, Chandler, Ben, Deighton, Kerry, Emma, Temlett, Haunch, Kirsty, Cheeseman, Michelle, Dent, Kathy, Garg, Sanjeev, Gray, Carol, Hood, Marion, Jones, Dawn, Juj, Joanne, Rao, Roshan, Walker, Tara, Al Anizi, Mashel, Cheah, Clarissa, Cheing, Yushio, Coutinho, Francisco, Gondo, Prisca, Hadebe, Bernard, Onie Hove, Mazvangu, khader, Ahamed, Krishnachetty, Bobby, Rhodes, Karen, Sokhi, Jagdish, Baker, Katie-Anne, Bertram, Wendy, Looseley, Alex, Mouton, Ronelle, Arnold, Glenn, Arya, Shobhit, Balfoussia, Danai, Baxter, Linden, Harris, Jame, Jones, Craig, Knaggs, Alison, Markar, Sheraz, Perera, Anisha, Scott, Alasdair, Shida, Asako, Sirha, Ravneet, Wright, Sally, Frost, Victoria, Gray, Catherine, MacGregor, Mark, Andrews, Emma, Arrandale, Lindsay, Barrett, Stephen, Cifra, Elna, Cooper, Mariese, Dragnea, Drago, Elna, Cifra, Maclean, Jennifer, Meier, Sonja, Milliken, Donald, Munns, Christopher, Ratanshi, Nadir, Salvana, Abegail, Watson, Anthony, Ali, Hani, Campbell, Gill, Critchley, Rebecca, Hicks, Catherine, Liddle, Alison, Pass, Marc, Ritchie, Charlotte, Thomas, Charlotte, Too, Lingxi, Welsh, Sarah, Gill, Talvinder, Johnson, Joanne, Reed, Joanne, Davis, Edward, Papadopoullos, Sam, Attwood, Clare, Biffen, Andrew, Boulton, Kerenza, Gray, Sophie, Hay, David, Mills, Sarah, Montgomery, Jane, Riddell, Rory, Simpson, Jame, Bhardwaj, Neeraj, Paul, Elaine, Uwubamwen, Nosakhare, Alexander, Maini, Arrich, Jame, Arumugam, Swarna, Blackwood, Dougla, Boggiano, Victoria, Brown, Robyn, Lam Chan, Yik, Chatterjee, Devnandan, Chhabra, Ashok, Christian, Rachel, Costelloe, Hannah, Coxwell Matthewman, Madeline, Dalton, Emma, Darko, Julia, Davari, Maria, Dave, Tejal, Deacon, Matthew, Deepak, Shantal, Edmond, Holly, Ellis, Jessica, El-Sayed, Ahmed, Eneje, Philip, English, Rose, Ewe, Renee, Foers, William, Franklin, John, Gallego, Laura, Garrett, Emily, Goldberg, Olivia, Goss, Harry, Greaves, Rosanna, Harris, Rudy, Hennings, Charle, Jones, Eleanor, Kamali, Nelson, Kokkinos, Naomi, Lewis, Cary, Lignos, Leda, Malgapo, Evaleen Victoria, Malik, Rizwana, Milne, Andrew, Mulligan, John-Patrick, Nicklin, Philippa, Palipane, Natasha, Parsons, Thoma, Piper, Rebecca, Prakash, Rohan, Ramesh, Byron, Rasip, Sarah, Reading, Jacob, Rela, Mariam, Reyes, Anna, Robert, Stephen, Rooms, Martin, Shah, Karishma, Simons, Henry, Solanki, Shalil, Spowart, Emma, Stevens, Amy, Thomas, Christopher, Waggett, Helena, Yassaee, Arrash, Kennedy, Anthony, Scott, Sara, Somanath, Sameer, Berg, Andrew, Hernandez, Miguel, Nanda, Rajesh, Tank, Ghanshyambhai, Wilson, Natalie, 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Tsang, M.S., Lai, M.L., Yip, C.P., Chan, HMH, Law, B., Li, W.S., Chu, H.M., Koo, EGY, Lam, CCJ, Cheng, K.H., Lam, T., Chu, S., Lam, W.Y., Wong, KWK, Kwok, D., Hung, CYJ, Chan, WKJ, LamWong, W., Chung, CKE, Ma, S.K., Kaushik, S., Shah, B., Shah, D., Shah, S., Ar, P., Muthuchellappan, R., Agarwal, V., Divatia, J., Mishra, S., Nimje, G., Pande, S., Savarkar, S., Shrivastava, A., Thomas, M., Yegnaram, S., Hidayatullah, R., Puar, N., Niman, S., Indra, I., Hamzah, Z., Yuliana, A., Abidin, U.N., Dursin, A.N., Kurnia, A., Susanti, A., Handayani, D., Aribawa, M.A., Arya, A., Senapathi, TGA, Utara, U.H., Wid, W.M., Wima, S., Wir, W.M., Jehosua, B., Kaunang, J., Lantang, E.Y., Najoan, R., Waworuntu, N., Awad, H., Fuad, A., Geddoa, B., Khalaf, A.R., Al Hussaini, S., Albaj, S., Kenber, M., Bettinelli, A., Spadaro, S., Volta, C.A., Giancarlo, L., Sottosanti, V., Spagnesi, L., Toretti, I., Alloj, C., Cardellino, S., Carmino, L., Costanzo, E., Fanfani, L.C., Novelli, M.T., Roasio, A., Bellandi, M., Bignami, E., Bocchino, S., Cabrini, L., Corti, D., Landoni, G., Meroni, R., Moizo, E., Monti, G., Pintaudi, M., Plumari, V.P., Taddeo, D., Testa, V., Winterton, D., Zangrillo, A., Cloro, L.M., Colangelo, C., Colangelo, A., Rotunno, G., Angel, M.P., Maria, C.P., Pata, A., Parrini, V., Gatta, A., Nastasi, M., Tinti, C., Arrigo, M., Benevento, A., Bottini, C., Cannavo', M., Gastaldi, C., Marchesi, A., Pascazio, A., Pata, F., Pozzi, E., Premoli, A., Tessera, G., Boschi, L., D'Andrea, R., Ghignone, F., Poggioli, G., Sibilio, A., Taffurelli, M., Ugolini, G., Ab Majid, M.A., Ab Rahman, R., Joseph, J., Pathan, F., Shah, MHS, Yap, H.L., Cheah, S., Chin, I.I., Looi, J.K., Tan, S.C., Visvalingam, S., Kwok, F.Y., Lee, C.K., Tan, T.S., Wong, S.M., Abdullah, N.H., Liew, C.F., Luxuman, L., Mohd Zin, N.H., Norddin, M.F., Alias, RLR, Wong, J.Y., Yong, J., Bin Mustapha, M.T., Chan, W.K., Dzulkipli, N., Kuan, P.X., Lee, Y.C., Alias, A., Guok, E.C., Jee, C.C., Ramon, B.R., Weng, C.W., Abd Ghafar, FNI, Aziz, F.Z., Hussain, N., Lee, H.S., Sukawi, I., Woon, Y.L., Abd Hadi, H.Z., Ahmad Azam, U.A., Alias, A.H., Kesut, S.A., Lee, J.M., Ooi, D.V., Sulaiman, H.A., Tengku Lih, T.A., Veerakumaran, J., Rojas, E., Resendiz, GEA, Zapata, DDM, Aguilar López, JCJ, Flores, AAA, Amador, JCB, Avila, EJD, Aquino, LPG, Rodriguez, R.L., Landa, M.T., Urias, E., Hollmann, M., Hulst, A., Kirzner, O., Preckel, B., Koopman-van Gemert, A., Buise, M., Tolenaar, N., Weber, E., de Fretes, J., Houweling, P., Ormskerk, P., Van Bommel, J., Lance, M., Smit-Fun, V., van Zundert, T., Baas, P., de Boer, H.D., Sprakel, J., Elferink-Vonk, R., Noordzij, P., van Zeggeren, L., Brand, B., Spanjersberg, R., Ten Bokkel-Andela, J., Numan, J., van Klei, W., van Zaane, B., Boer, C., van Duivenvoorde, Y., Hering, J.P., Zonneveldt, H., Hoare, S., Santa, S., Allen, S.J., Bell, R., Choi, H.D., Drake, M., Farrell, H., Higgie, K., Holmes, K., Jenkins, N., Kim, C.J., Kim, S., Law, K.C., McAllister, D., Park, K., Pedersen, K., Pfeifer, L., Salmond, T., Steynor, M., Tan, M., Waymouth, E., Ab Rahman, A.S., Armstrong, J., Dudson, R., Nilakant, J., Richard, S., Virdi, P., Dixon, L., Donohue, R., Farrow, M., Kennedy, R., Marissa, H., McKellow, M., Nicola, D., Pascoe, R., Roberts, S.J., Rowell, G., Sumner, M., Templer, P., Chandrasekharan, S., Fulton, G., Jammer, I., Ali, M., More, R., Wilson, L., Chang, Y.H., Chang, J., Fowler, C., Panckhurst, J., Sara, R., Stapelberg, F., Cherrett, V., Ganter, D.L., McCann, L., Foley, J., Gilmour, F., Lumsden, R., Moores, M., Olliff, S., Sardareva, E., Tai, J., Wikner, M., Wong, C., Chaddock, M., Czepanski, C., McKendry, P., Polakovic, D., Polakovich, D., Robert, A., Tormo Belda, M., Norton, T., Alherz, F., Barneto, L., Ramirez, A., Sayeed, A., Smith, N., Bennett, C., McQuoid, S., Jansen, T.L., Nico, Z., Scott, J., Freschini, D., Freschini, A., Hopkins, B., Manson, L., Stoltz, D., Bates, A., Davis, S., Freeman, V., McGaughran, L., Baskar Sharma, S., Burrows, T., Byrne, K., English, D., Johnson, R., Chai Law, K., Manikkam, B., Naidoo, S., Rumball, M., Whittle, N., Franks, R., Gibson-Lapsley, H., Salter, R., Walsh, D., Cooper, R., Perry, K., Obobolo, A., Sule, U.M., Ahmad, A., Atiku, M., Mohammed, A.D., Sarki, A.M., Adekola, O., Akanmu, O., Durodola, A., Olukoju, O., Raji, V., Olajumoke, T., Oyebamiji, E., Adenekan, A., Adetoye, A., Faponle, F., Olateju, S., Owojuyigbe, A., Talabi, A., Adenike, O., Adewale, B., Collins, N., Ezekiel, E., Fatungase, O.M., Grace, A., Sola, S., Stella, O., Ademola, A., Adeolu, A.A., Adigun, T., Akinwale, M., Fasina, O., Gbolahan, O., Idowu, O., Olonisakin, R.P., Osinaike, B.B., Asudo, F., Mshelia, D., Abdur-Rahman, L., Agodirin, O., Bello, J., Bolaji, B., Oyedepo, O.O., Ezike, H., Iloabachie, I., Okonkwo, I., Onuora, E., Onyeka, T., Ugwu, I., Umeh, F., Alagbe-Briggs, O., Dodiyi-Manuel, A., Echem, R., Obasuyi, B., Onajin-Obembe, B., Bandeira, M.E., Tomé, M., Martins Costa, ACM, Krystopchuk, A., Branco, T., Esteves, S., Melo, M.A., Monte, J., Rua, F., Martins, I., Pinho-Oliveira, V.M., Rodrigues, C.M., Cabral, R., Marques, S., Rêgo, S., Teixeira Jesus, J.S., Conceição Marques, M., Romao, C., Dias, S., Santos, A.M., Alves, M.J., Salta, C., Cruz, S., Duarte, C., Furtado Paiva, A.A., do Nascimento Cabral, T., Fariae Maia, D., Correia da Silva, RFM, Langner, A., Oliveira Resendes, H., da Conceição Soares, M., Abrunhosa, A., Faria, F., Miranda, L., Pereira, H., Serra, S., Ionescu, D., Margarit, S., Mitre, C., Vasian, H., Manga, G., Stefan, A., Tomescu, D., Filipescu, D., Paunescu, M.A., Stefan, M., Stoica, R., Gavril, L., Pătrăşcanu, E., Ristescu, I., Rusu, D., Diaconescu, C., Iosep, G.F., Pulbere, D., Ursu, I., Balanescu, A., Grintescu, I., Mirea, L., Rentea, I., Vartic, M., Lupu, M.N., Stanescu, D., Streanga, L., Antal, O., Hagau, N., Patras, D., Petrisor, C., Tosa, F., Tranca, S., Copotoiu, S.M., Ungureanu, L.L., Harsan, C.R., Papurica, M., Cernea, D.D., Dragoescu, N.A., Aflori, L., Vaida, C., Ciobotaru, O.R., Aignatoaie, M., Carp, C.P., Cobzaru, I., Mardare, O., Purcarin, B., Tutunaru, V., Ionita, V., Arustei, M., Codita, A., Busuioc, M., Chilinciuc, I., Ciobanu, C., Belciu, I., Tincu, E., Blaj, M., Grosu, R.M., Sandu, G., Bruma, D., Corneci, D., Dutu, M., Krepil, A., Copaciu, E., Dumitrascu, C.O., Jemna, R., Mihaescu, F., Petre, R., Tudor, C., Ursache, E., Kulikov, A., Lubnin, A., Grigoryev, E., Pugachev, S., Tolmasov, A., Hussain, A., Ilyina, Y., Roshchina, A., Iurin, A., Chazova, E., Dunay, A., Karelov, A., Khvedelidze, I., Voldaeva, O., Belskiy, V., Dzhamullaev, P., Grishkowez, E., Kretov, V., Levin, V., Molkov, A., Puzanov, S., Samoilenko, A., Tchekulaev, A., Tulupova, V., Utkin, I., Allorto, N.L., Bishop, D.G., Builu, P.M., Cairns, C., Dasrath, A., de Wet, J., den Hoedt, M., Grey, B., Hayes, M.P., Küsel, B.S., Shangase, N., Wise, R., Cacala, S., Farina, Z., Govindasamy, V., Kruse, C.H., Lee, C., Marais, L., Naidoo, T.D., Rajah, C., Rodseth, R.N., Ryan, L., von Rhaden, R., Adam, S., Alphonsus, C., 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Makowski, A., Misztal, B., Moldovan, E., Pegg, C., Donovan, A., Foot, J., Large, S., Claxton, A., Netke, B., Armstrong, R., Calderwood, C., Kwok, A., Mohr, O., Oyeniyi, P., Patnaik, L., Post, B., Ali, S., Arshad, H., Baker, G., Brenner, L., Brincat, M., Brunswicker, A., Cox, H., Cozar, O.I., Durst, A., Fengas, L., Flatt, J., Glister, G., Narwani, V., Photi, E., Rankin, A., Rosbergen, M., Beaton, C., Horn, R., Hunt, J., Rousseau, G., Stancombe, L., Absar, M., Allsop, J., Drinkwater, Z., Hodgkiss, T., Smith, K., Alexander-Sefre, F., Campey, L., Dudgeon, L., Hall, K., Hitchcock, R., James, L., Winstone, U., Ahmad, N., Bauchmuller, K., Harrison, J., Jeffery, H., Miller, D., Pinder, A., Pothuneedi, S., Rosser, J., Sanghera, S., Swift, D., Walker, R., Bester, D., Cavanagh, S., Cripps, H., Daniel, H., Lynch, J., Pyke, S., Scholefield, J., Whitworth, H., Bottrill, F., Ramalingam, G., Webb, S., Akerman, N., Antill, P., Bourner, L., Buckley, S., Castle, G., Charles, R., Eggleston, C., Foster, R., Gill, S., Lindley, K., Lklouk, M., Lowery, T., Martin, O., Milne, D., O'Connor, P., Ratcliffe, A., Rose, A., Smith, A., Varma, S., Ward, J., Barcraft-Barnes, H., Camsooksai, J., Colvin, C., Reschreiter, H., Tbaily, L., Venner, N., Hamilton, C., Kelly, L., Toth-Tarsoly, P., Dodsworth, K., Foord, D., Gordon, P., Hawes, E., Lamb, N., Mouland, J., Nightingale, J., Rose, S., Schrieber, J., Al 'Amri, K., Aladin, H., Arshad, M.A., Barraclough, J., Bentley, C., Bergin, C., Carrera, R., Clarkson, A., Collins, M., Denham, S., Griffiths, E., Ip, P., Jeyanthan, S., Joory, K., Kaur, S., Marriott, P., Mitchell, N., Nagaiah, S., Nilsson, A., Parekh, N., Pope, M., Seager, J., Serag, H., Tameem, A., Thomas, A., Thunder, J., Torrance, A., Vohra, R., Whitehouse, A., Wong, T., Blunt, M., Wong, K., Giles, J., Reed, I., Weller, D., Bell, G., Birch, J., Damant, R., Maiden, J., Mewies, C., Prince, C., Radford, J., Balain, B., Banerjee, R., Barnett, A., Burston, B., Edwards, J., Evans, C., Ford, D., Gallacher, P., Hill, S., Jaffray, D., Karlakki, S., Kennedy, J., Kiely, N., Lewthwaite, S., Marquis, C., Ockendon, M., Phillips, S., Pickard, S., Richardson, J., Roach, R., Smith, T., Spencer-Jones, R., Steele, N., Steen, J., Van Liefland, M., White, S., Faulds, M., Harris, M., Nicol, S., Pearson, S.A., Chukkambotla, S., Andrew, A., Attrill, E., Campbell, G., Datson, A., Fouracres, A., Graterol, J., Graves, L., Hong, B., Ishimaru, A., Karthikeyan, A., King, H., Lawson, T., Lee, G., Lyons, S., Macalister Hall, A., Mathoulin, S., Mcintyre, E., Mclaughlin, D., Mulcahy, K., Robbins, J., Sung, W., Tayo, A., Trembath, L., Venugopal, S., Wigmore, G., Boereboom, C., Downes, C., Humphries, R., Melbourne, S., Tou, S., Ullah, S., Batchelor, N., Boxall, L., Broomby, R., Deen, T., Hellewell, A., Helliwell, L., Hutchings, M., Hutchins, D., Keenan, S., Mackie, D., Donna, A., Smith, F., Stone, L., Thorpe, K., Wassall, R., Woodgate, A., Baillie, S., Campbell, T., James, S., King, C., Marques de Araujo, D., Martin, D., Morkane, C., Neely, J., Rajendram, R., Burton, M., James, K., Keevil, E., Minik, O., Morgan, J., Musgrave, A., Rajanna, H., Roberts, T., Adamson, M., Jumbe, S., Kendall, J., Muthuswamy, M.B., Cruikshanks, A., Wrench, I., Zeidan, L., Ardern, D., Harris, B., Hellstrom, J., Martin, J., Thomas, R., Varsani, N., Wrey Brown, C., Docherty, P., Gillies, M., McGregor, E., Usher, H., Craig, J., Ahmad, T., Bodger, P., Creary, T., Fowler, A., Ijuo, E., Jones, T., Kantsedikas, I., Lahiri, S., McLean, A.L., Niebrzegowska, E., Phull, M., Wickboldt, N., Baldwin, J., Doyle, D., Mcmullan, S., Oladapo, M., Owen, T., Williams, A., Gregory, P., Husain, T., Kirk-Bayley, J., Mathers, E., Montague, L., Avis, J., Cook, T., Dali-Kemmery, L., Kerslake, I., Lambourne, V., Pearson, A., Boyd, C., Callaghan, M., Lawson, C., McCrossan, R., Nesbitt, V., O'connor, L., Sinclair, R., Farid, N., Morgese, C., Bhatia, K., Karmarkar, S., Ahmed, J., Branagan, G., Hutton, M., Swain, A., Brookes, J., Cornell, J., Dolan, R., Hulme, J., Jansen van Vuuren, A., Jowitt, T., Kalashetty, G., Lloyd, F., Patel, K., Sherwood, N., Brown, L., Chandler, B., Deighton, K., Emma, T., Haunch, K., Cheeseman, M., Dent, K., Gray, C., Hood, M., Jones, D., Juj, J., Rao, R., Walker, T., Al Anizi, M., Cheah, C., Cheing, Y., Coutinho, F., Gondo, P., Hadebe, B., Onie Hove, M., Khader, A., Krishnachetty, B., Rhodes, K., Sokhi, J., Baker, K.A., Bertram, W., Looseley, A., Mouton, R., Arnold, G., Arya, S., Balfoussia, D., Baxter, L., Harris, J., Jones, C., Knaggs, A., Markar, S., Perera, A., Scott, A., Shida, A., Sirha, R., Wright, S., Frost, V., MacGregor, M., Andrews, E., Arrandale, L., Barrett, S., Cifra, E., Cooper, M., Dragnea, D., Elna, C., Maclean, J., Meier, S., Milliken, D., Munns, C., Ratanshi, N., Salvana, A., Watson, A., Ali, H., Critchley, R., Hicks, C., Liddle, A., Pass, M., Ritchie, C., Thomas, C., Too, L., Welsh, S., Gill, T., Johnson, J., Reed, J., Davis, E., Papadopoullos, S., Attwood, C., Biffen, A., Boulton, K., Gray, S., Hay, D., Mills, S., Montgomery, J., Riddell, R., Simpson, J., Bhardwaj, N., Paul, E., Uwubamwen, N., Alexander, M., Arrich, J., Arumugam, S., Blackwood, D., Boggiano, V., Lam Chan, Y., Chatterjee, D., Chhabra, A., Christian, R., Costelloe, H., Coxwell Matthewman, M., Dalton, E., Darko, J., Davari, M., Dave, T., Deacon, M., Deepak, S., Edmond, H., Ellis, J., El-Sayed, A., Eneje, P., English, R., Ewe, R., Foers, W., Franklin, J., Gallego, L., Garrett, E., Goldberg, O., Goss, H., Greaves, R., Harris, R., Hennings, C., Jones, E., Kamali, N., Kokkinos, N., Lewis, C., Lignos, L., Malgapo, E.V., Malik, R., Milne, A., Mulligan, J.P., Nicklin, P., Palipane, N., Parsons, T., Piper, R., Prakash, R., Ramesh, B., Rasip, S., Reading, J., Rela, M., Reyes, A., Robert, S., Rooms, M., Shah, K., Simons, H., Solanki, S., Spowart, E., Stevens, A., Waggett, H., Yassaee, A., Kennedy, A., Scott, S., Somanath, S., Berg, A., Hernandez, M., Nanda, R., Tank, G., Wilson, N., Wilson, D., Al-Soudaine, Y., Baldwin, M., Cornish, J., Davies, Z., Davies, L., Edwards, M., Frewer, N., Gallard, S., Glasbey, J., Harries, R., Hopkins, L., Kim, T., Koompirochana, V., Lawson, S., Lewis, M., Makzal, Z., Scourfield, S., Ahmad, Y., Bates, S., Blackwell, C., Bryant, H., Coulter, S., Cruickshank, R., Daniel, S., Daubeny, T., Golder, K., Hawkins, L., Helen, B., Hinxman, H., Levett, D., Skinner, B., Walsgrove, J., Dickson, J., Constantin, K., Karen, M., O'Brien, P., O'Donohoe, L., Payne, H., Sundayi, S., Walker, E., Brooke, J., Cardy, J., Humphreys, S., Kessack, L., Kubitzek, C., Kumar, S., Cotterill, D., Hodzovic, E., Hosdurga, G., Miles, E., Saunders, G., Campbell, M., Chan, P., Jemmett, K., Raj, A., Naik, A., Ramamoorthy, R., Shah, N., Sylvan, A., Blyth, K., Burtenshaw, A., Freeman, D., Johnson, E., Lo, P., Martin, T., Plunkett, E., Wollaston, J., Allison, J., Carroll, C., Craw, N., Craw, S., Pitt-Kerby, T., Rowland-Axe, R., Spurdle, K., McDonald, A., Simon, D., Sinha, V., Banner-Goodspeed, V., Boone, M., Campbell, K., Lu, F., Scannell, J., Sobol, J., Balajonda, N., Clemmons, K., Conde, C., Funk, B., Hopkins, T., Olaleye, O., Omer, O., Pender, M., Porto, A., Waweru, P., Yeh, E., Bodansky, D., Evans, A., Kleopoulos, S., Maril, R., Mathney, E., Sanchez, A., Tinuoye, E., Bateman, B., Eng, K., Jiang, N., Ladha, K., Needleman, J., Chen, L.L., Lane, R., Robinowitz, D., Ghushe, N., Irshad, M., Patel, S., Takemoto, S., Wallace, A., Mazzeffi, M., Rock, P., Wallace, K., Zhu, X., Chua, P., Mattera, M., Sharar, R., Thilen, S., Treggiari, M., Morgan, A., Sofjan, I., Subramaniam, K., Avidan, M., Maybrier, H., Muench, M., and Wildes, T.
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Male ,HSJ UCI ,Critical Care and Intensive Care Medicine ,law.invention ,Perioperative Care/methods ,0302 clinical medicine ,Surgical procedures ,030202 anesthesiology ,law ,Critical care/utilisation, Postoperative care/methods, Postoperative care/statistics and numerical data, Surgical procedures, operative/mortality ,statistics and numerical data ,Prospective Studies ,Postoperative Period ,Postoperative care/methods ,education.field_of_study ,Postoperative care/method ,Elective Surgical Procedures/mortality ,fluid output ,Middle Aged ,fluid administration ,Intensive care unit ,Hospitalization ,Length of Stay/statistics & numerical data ,operative/mortality ,Intensive Care Units/statistics & numerical data ,outcome ,Female ,Elective Surgical Procedure ,Human ,Adult ,medicine.medical_specialty ,Logistic Model ,Postoperative care/statistics and numerical data ,Critical care/utilisation ,Population ,Intensive Care Unit ,Elective Surgical Procedures/statistics & numerical data ,Hospitalization/statistics & numerical data ,Humans ,Logistic Models ,Surgical procedures, operative/mortality ,Postoperative care ,methods ,Perioperative Care ,NO ,03 medical and health sciences ,Anesthesiology ,Intensive care ,medicine ,Elective surgery ,Intensive care medicine ,education ,business.industry ,030208 emergency & critical care medicine ,Perioperative ,Length of Stay ,Clinical trial ,Prospective Studie ,septic shock ,business - Abstract
PURPOSE: As global initiatives increase patient access to surgical treatments, there is a need to define optimal levels of perioperative care. Our aim was to describe the relationship between the provision and use of critical care resources and postoperative mortality. METHODS: Planned analysis of data collected during an international 7-day cohort study of adults undergoing elective in-patient surgery. We used risk-adjusted mixed-effects logistic regression models to evaluate the association between admission to critical care immediately after surgery and in-hospital mortality. We evaluated hospital-level associations between mortality and critical care admission immediately after surgery, critical care admission to treat life-threatening complications, and hospital provision of critical care beds. We evaluated the effect of national income using interaction tests. RESULTS: 44,814 patients from 474 hospitals in 27 countries were available for analysis. Death was more frequent amongst patients admitted directly to critical care after surgery (critical care: 103/4317 patients [2%], standard ward: 99/39,566 patients [0.3%]; adjusted OR 3.01 [2.10-5.21]; p < 0.001). This association may differ with national income (high income countries OR 2.50 vs. low and middle income countries OR 4.68; p = 0.07). At hospital level, there was no association between mortality and critical care admission directly after surgery (p = 0.26), critical care admission to treat complications (p = 0.33), or provision of critical care beds (p = 0.70). Findings of the hospital-level analyses were not affected by national income status. A sensitivity analysis including only high-risk patients yielded similar findings. CONCLUSIONS: We did not identify any survival benefit from critical care admission following surgery. info:eu-repo/semantics/publishedVersion
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- 2017
37. Central neurodegeneration in Kennedy's disease accompanies peripheral motor dysfunction.
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Tu S, Li T, Carroll AS, Mahoney CJ, Huynh W, Park SB, Henderson R, Vucic S, Kiernan MC, and Lin CS
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- Humans, Male, Middle Aged, Female, Aged, Adult, Amyotrophic Lateral Sclerosis physiopathology, Amyotrophic Lateral Sclerosis pathology, Amyotrophic Lateral Sclerosis diagnostic imaging, Brain diagnostic imaging, Brain pathology, Brain physiopathology, Magnetic Resonance Imaging, White Matter diagnostic imaging, White Matter pathology, White Matter physiopathology, Bulbo-Spinal Atrophy, X-Linked physiopathology, Bulbo-Spinal Atrophy, X-Linked pathology
- Abstract
Spinal and bulbar muscular atrophy (SBMA), or Kennedy's disease (KD), is a rare hereditary neuromuscular disorder demonstrating commonalities with amyotrophic lateral sclerosis (ALS). The current study aimed to define functional and central nervous system abnormalities associated with SBMA pathology, their interaction, and to identify novel clinical markers for quantifying disease activity. 27 study participants (12 SBMA; 8 ALS; 7 Control) were recruited. SBMA patients underwent comprehensive motor and sensory functional assessments, and neurophysiological testing. All participants underwent whole-brain structural and diffusion MRI. SBMA patients demonstrated marked peripheral motor and sensory abnormalities across clinical assessments. Increased abnormalities on neurological examination were significantly associated with increased disease duration in SBMA patients (R
2 = 0.85, p < 0.01). Widespread juxtacortical axonal degeneration of corticospinal white matter tracts were detected in SBMA patients (premotor; motor; somatosensory; p < 0.05), relative to controls. Increased axial diffusivity was significantly correlated with total neuropathy score in SBMA patients across left premotor (R2 = 0.59, p < 0.01), motor (R2 = 0.63, p < 0.01), and somatosensory (R2 = 0.61, p < 0.01) tracts. The present series has identified involvement of motor and sensory brain regions in SBMA, associated with disease duration and increasing severity of peripheral neuropathy. Quantification of annualized brain MRI together with Total Neuropathy Score may represent a novel approach for clinical monitoring., (© 2024. The Author(s).)- Published
- 2024
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38. Novel approaches to assessing upper motor neuron dysfunction in motor neuron disease/amyotrophic lateral sclerosis: IFCN handbook chapter.
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Dharmadasa T, Pavey N, Tu S, Menon P, Huynh W, Mahoney CJ, Timmins HC, Higashihara M, van den Bos M, Shibuya K, Kuwabara S, Grosskreutz J, Kiernan MC, and Vucic S
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- Humans, Evoked Potentials, Motor physiology, Motor Cortex physiopathology, Motor Cortex diagnostic imaging, Amyotrophic Lateral Sclerosis physiopathology, Amyotrophic Lateral Sclerosis diagnosis, Transcranial Magnetic Stimulation methods, Motor Neuron Disease physiopathology, Motor Neuron Disease diagnosis, Motor Neurons physiology
- Abstract
Identifying upper motor neuron (UMN) dysfunction is fundamental to the diagnosis and understanding of disease pathogenesis in motor neuron disease (MND). The clinical assessment of UMN dysfunction may be difficult, particularly in the setting of severe muscle weakness. From a physiological perspective, transcranial magnetic stimulation (TMS) techniques provide objective biomarkers of UMN dysfunction in MND and may also be useful to interrogate cortical and network function. Single, paired- and triple pulse TMS techniques have yielded novel diagnostic and prognostic biomarkers in MND, and have provided important pathogenic insights, particularly pertaining to site of disease onset. Cortical hyperexcitability, as heralded by reduced short interval intracortical inhibition (SICI) and increased short interval intracortical facilitation, has been associated with the onset of lower motor neuron degeneration, along with patterns of disease spread, development of specific clinical features such as the split hand phenomenon, and may provide an indication about the rate of disease progression. Additionally, reduction of SICI has emerged as a potential diagnostic aid in MND. The triple stimulation technique (TST) was shown to enhance the diagnostic utility of conventional TMS measures in detecting UMN dysfunction in MND. Separately, sophisticated brain imaging techniques have uncovered novel biomarkers of neurodegeneration that have bene associated with progression. The present review will discuss the utility of TMS and brain neuroimaging derived biomarkers of UMN dysfunction in MND, focusing on recently developed TMS techniques and advanced neuroimaging modalities that interrogate structural and functional integrity of the corticomotoneuronal system, with an emphasis on pathogenic, diagnostic, and prognostic utility., (Copyright © 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
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- 2024
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39. Identification of small molecule inhibitors of G3BP-driven stress granule formation.
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Freibaum BD, Messing J, Nakamura H, Yurtsever U, Wu J, Kim HJ, Hixon J, Lemieux RM, Duffner J, Huynh W, Wong K, White M, Lee C, Meyers RE, Parker R, and Taylor JP
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- Poly-ADP-Ribose Binding Proteins genetics, RNA Recognition Motif Proteins genetics, DNA Helicases genetics, RNA Helicases genetics, Stress Granules
- Abstract
Stress granule formation is triggered by the release of mRNAs from polysomes and is promoted by the action of the RNA-binding proteins G3BP1/2. Stress granules have been implicated in several disease states, including cancer and neurodegeneration. Consequently, compounds that limit stress granule formation or promote their dissolution have potential as both experimental tools and novel therapeutics. Herein, we describe two small molecules, G3BP inhibitor a and b (G3Ia and G3Ib), designed to bind to a specific pocket in G3BP1/2 that is targeted by viral inhibitors of G3BP1/2 function. In addition to disrupting the co-condensation of RNA, G3BP1, and caprin 1 in vitro, these compounds inhibit stress granule formation in cells treated prior to or concurrent with stress and dissolve pre-existing stress granules. These effects are consistent across multiple cell types and a variety of initiating stressors. Thus, these compounds represent powerful tools to probe the biology of stress granules and hold promise for therapeutic interventions designed to modulate stress granule formation., (© 2024 Freibaum et al.)
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- 2024
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40. Enhancing Campus Safety: Exploring Student Perspectives on a Text Message-Delivered Intervention for Addressing Sexual Violence and Alcohol Use.
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Anderson JC, Nguyen MU, Huynh W, Sharif K, and Draughon Moret JE
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- Female, Humans, Male, Interpersonal Relations, Students, Universities, Text Messaging, Sex Offenses prevention & control, Rape
- Abstract
Background: Alcohol-related sexual violence, including sexual coercion, nonconsensual contact, and rape, is prevalent on college campuses., Aim: The purpose of the study was to investigate college students' feedback and recommendations regarding content for a text-message-delivered harm reduction intervention to jointly address alcohol use and alcohol's role in sexual violence risk., Methods: This qualitative thematic study used focus groups and individual interviews to collect feedback from 61 college students between February 2019 and July 2020., Results: Targeted recruitment resulted in a sample that was nearly half queer/ lesbian, gay, bisexual (46.2%) or trans* (9.8%) identified students. Participants endorsed text messaging as an effective way to reach college students but diverged in specific content they felt was relevant and appropriate for a universal education intervention. Students preferred content describing individual strategies versus those requiring collaboration from friends or potential sex partners. Students also preferred content phrased as suggestions or questions versus declarative statements. Although most participants recognized the value of content related to consent, sexual violence, sexual health, and resources, a few male-identifying participants failed to recognize that content as important to their experience. Maintaining brevity while discussing consent in the overlapping settings of drinking and interpersonal relationships was described as a particular challenge., Impact of This Work on Campus Sexual Assault and Forensic Nursing: Students in our sample highlighted the challenges of sharing sexual violence and alcohol-related harm reduction text messaging because of the complexities of rape culture, consent, and interpersonal dynamics during college student drinking events., Competing Interests: The authors declare no conflict of interest., (Copyright © 2023 International Association of Forensic Nurses.)
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- 2024
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41. Putting the "learning" in "pre-learning": effects of a self-directed study hall on skill acquisition in a simulation-based central line insertion course.
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Diederich E, Lineberry M, Schott V, Broski J, Alsayer A, Eckels KA, Murray MJ, Huynh W, and Thomas LA
- Abstract
Background: Opportunities to practice procedural skills in the clinical learning environment are decreasing, and faculty time to coach skills is limited, even in simulation-based training. Self-directed learning with hands-on practice early in a procedural skill course might help maximize the benefit of later faculty coaching and clinical experience. However, it may also lead to well-learned errors if learners lack critical guidance. The present study sought to investigate the effects of a hands-on, self-directed "study hall" for central line insertion among first-year residents., Methods: Learner cohorts before vs. after introduction of the study hall (n = 49) were compared on their pre- and post-test performance of key procedural behaviors that were comparable across cohorts, with all learners receiving traditional instructor-led training between tests., Results: Study hall participants spent a median of 116 min in hands-on practice (range 57-175). They scored higher at pre-test (44% vs. 27%, p = .00; Cohen's d = 0.95) and at post-test (80% vs. 72%, p = .02; Cohen's d = 0.69). A dose-response relationship was found, such that 2 h of study hall were roughly equivalent to the performance improvement seen with four clinical observations or supervised insertions of central lines., Conclusions: Self-directed, hands-on "study hall" supported improved procedural skill learning in the context of limited faculty availability. Potential additional benefits make the approach worth further experimentation and evaluation., (© 2023. Society in Europe for Simulation Applied to Medicine (SESAM) and BioMed Central Ltd.)
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- 2023
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42. Identification of small molecule inhibitors of G3BP-driven stress granule formation.
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Freibaum BD, Messing J, Nakamura H, Yurtsever U, Wu J, Kim HJ, Hixon J, Lemieux R, Duffner J, Huynh W, Wong K, White M, Lee C, Meyers R, Parker R, and Taylor JP
- Abstract
Stress granule formation is triggered by the release of mRNAs from polysomes and is promoted by the action of the paralogs G3BP1 and G3BP2. G3BP1/2 proteins bind mRNAs and thereby promote the condensation of mRNPs into stress granules. Stress granules have been implicated in several disease states, including cancer and neurodegeneration. Consequently, compounds that limit stress granule formation or promote their dissolution have potential as both experimental tools and novel therapeutics. Herein, we describe two small molecules, referred to as G3BP inhibitor a and b (G3Ia and G3Ib), designed to bind to a specific pocket in G3BP1/2 that is known to be targeted by viral inhibitors of G3BP1/2 function. In addition to disrupting co-condensation of RNA, G3BP1, and caprin 1 in vitro , these compounds inhibit stress granule formation in cells treated prior to or concurrent with stress, and dissolve pre-existing stress granules when added to cells after stress granule formation. These effects are consistent across multiple cell types and a variety of initiating stressors. Thus, these compounds represent ideal tools to probe the biology of stress granules and hold promise for therapeutic interventions designed to modulate stress granule formation., Competing Interests: Conflict of interest: JPT is a consultant for Nido Biosciences.
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- 2023
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43. Efficacy and safety of CNM-Au8 in amyotrophic lateral sclerosis (RESCUE-ALS study): a phase 2, randomised, double-blind, placebo-controlled trial and open label extension.
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Vucic S, Menon P, Huynh W, Mahoney C, Ho KS, Hartford A, Rynders A, Evan J, Evan J, Ligozio S, Glanzman R, Hotchkin MT, and Kiernan MC
- Abstract
Background: CNM-Au8® is a catalytically-active gold nanocrystal neuroprotective agent that enhances intracellular energy metabolism and reduces oxidative stress. The phase 2, randomised, double-blind, placebo-controlled trial and open label extension RESCUE-ALS trial evaluated the efficacy and safety of CNM-Au8 for treatment of amyotrophic lateral sclerosis (ALS)., Methods: RESCUE-ALS and its long-term open label extension (OLE) were conducted at two multidisciplinary ALS clinics located in Sydney, Australia: (i) the Brain and Mind Centre and (ii) Westmead Hospital. The double-blind portion of RESCUE-ALS was conducted from January 16, 2020 (baseline visit, first-patient first-visit (FPFV)) through July 13, 2021 (double-blind period, last-patient last-visit (LPLV)). Participants (N = 45) were randomised 1:1 to receive 30 mg of CNM-Au8 or matching placebo daily over 36 weeks in addition to background standard of care, riluzole. The primary outcome was mean percent change in summed motor unit number index (MUNIX), a sensitive neurophysiological biomarker of lower motor neuron function. Change in total (or summated) MUNIX score and change in forced vital capacity (FVC) were secondary outcome measures. ALS disease progression events, ALS Functional Rating Scale (ALSFRS-R) change, change in quality of life (ALSSQOL-SF) were assessed as exploratory outcome measures. Long-term survival evaluated vital status of original active versus placebo randomisation for all participants through at least 12 months following last-patient last-visit (LPLV) of the double-blind period. RESCUE-ALS and the open label study are registered in clinicaltrials.gov with registration numbers NCT04098406 and NCT05299658, respectively., Findings: In the intention-to-treat (ITT) population, there was no significant difference in the summated MUNIX score percent change (LS mean difference: 7.7%, 95% CI: -11.9 to 27.3%, p = 0.43), total MUNIX score change (18.8, 95% CI: -56.4 to 94.0), or FVC change (LS mean difference: 3.6, 95% CI: -12.4 to 19.7) between the active and placebo treated groups at week 36. In contrast, survival analyses through 12-month LPLV demonstrated a 60% reduction in all-cause mortality with CNM-Au8 treatment [hazard ratio = 0.408 (95% Wald CI: 0.166 to 1.001, log-rank p = 0.0429). 36 participants entered the open label extension (OLE), and those initially randomised to CNM-Au8 exhibited a slower rate of disease progression, as measured by time to the occurrence of death, tracheostomy, initiation of non-invasive ventilatory support, or gastrostomy tube placement. CNM-Au8 was well-tolerated, and no safety signals were observed., Interpretation: CNM-Au8, in combination with riluzole, was well-tolerated in ALS with no identified safety signals. While the primary and secondary outcomes of this trial were not significant, the clinically meaningful exploratory results support further investigation of CNM-Au8 in ALS., Funding: The RESCUE-ALS was substantially funded by a grant from FightMND. Additional funding was provided by Clene Australia Pty Ltd., Competing Interests: AR, KSH, RG, AH, JaE, JeE, and MTH are full time employees and hold stock or options in Clene Nanomedicine. SL is an employee of Instat Clinical Research, a clinical research organization contracted by Clene Nanomedicine. SV and MCK are directors of companies that hold equity in Clene Nanomedicine. SV, MCK, and their respective institutions receive research funding support for the Rescue-ALS study from Clene Nanomedicine. MCK was Editor-in-Chief of the Journal of Neurology, Neurosurgery and Psychiatry (BMJ Publishers, UK)., (© 2023 The Author(s).)
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- 2023
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44. CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database.
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Alcock BP, Huynh W, Chalil R, Smith KW, Raphenya AR, Wlodarski MA, Edalatmand A, Petkau A, Syed SA, Tsang KK, Baker SJC, Dave M, McCarthy MC, Mukiri KM, Nasir JA, Golbon B, Imtiaz H, Jiang X, Kaur K, Kwong M, Liang ZC, Niu KC, Shan P, Yang JYJ, Gray KL, Hoad GR, Jia B, Bhando T, Carfrae LA, Farha MA, French S, Gordzevich R, Rachwalski K, Tu MM, Bordeleau E, Dooley D, Griffiths E, Zubyk HL, Brown ED, Maguire F, Beiko RG, Hsiao WWL, Brinkman FSL, Van Domselaar G, and McArthur AG
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- Anti-Bacterial Agents pharmacology, Genes, Bacterial, Likelihood Functions, Software, Molecular Sequence Annotation, Databases, Factual, Drug Resistance, Microbial, Machine Learning, Data Curation
- Abstract
The Comprehensive Antibiotic Resistance Database (CARD; card.mcmaster.ca) combines the Antibiotic Resistance Ontology (ARO) with curated AMR gene (ARG) sequences and resistance-conferring mutations to provide an informatics framework for annotation and interpretation of resistomes. As of version 3.2.4, CARD encompasses 6627 ontology terms, 5010 reference sequences, 1933 mutations, 3004 publications, and 5057 AMR detection models that can be used by the accompanying Resistance Gene Identifier (RGI) software to annotate genomic or metagenomic sequences. Focused curation enhancements since 2020 include expanded β-lactamase curation, incorporation of likelihood-based AMR mutations for Mycobacterium tuberculosis, addition of disinfectants and antiseptics plus their associated ARGs, and systematic curation of resistance-modifying agents. This expanded curation includes 180 new AMR gene families, 15 new drug classes, 1 new resistance mechanism, and two new ontological relationships: evolutionary_variant_of and is_small_molecule_inhibitor. In silico prediction of resistomes and prevalence statistics of ARGs has been expanded to 377 pathogens, 21,079 chromosomes, 2,662 genomic islands, 41,828 plasmids and 155,606 whole-genome shotgun assemblies, resulting in collation of 322,710 unique ARG allele sequences. New features include the CARD:Live collection of community submitted isolate resistome data and the introduction of standardized 15 character CARD Short Names for ARGs to support machine learning efforts., (© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.)
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- 2023
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45. Formation of a Strong Heterogeneous Aluminum Lewis Acid on Silica.
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Samudrala KK, Huynh W, Dorn RW, Rossini AJ, and Conley MP
- Abstract
Al(OC(CF
3 )3 )(PhF) reacts with silanols present on partially dehydroxylated silica to form well-defined ≡SiOAl(OC(CF3 )3 )2 (O(Si≡)2 ) (1).27 Al NMR and DFT calculations with a small cluster model to approximate the silica surface show that the aluminum in 1 adopts a distorted trigonal bipyramidal coordination geometry by coordinating to a nearby siloxane bridge and a fluorine from the alkoxide. Fluoride ion affinity (FIA) calculations follow experimental trends and show that 1 is a stronger Lewis acid than B(C6 F5 )3 and Al(OC(CF3 )3 )(PhF) but is weaker than Al(OC(CF3 )3 ) andi Pr3 Si+ . Cp2 Zr(CH3 )2 reacts with 1 to form [Cp2 ZrCH3 ][≡SiOAl(OC(CF3 )3 )2 (CH3 )] (3) by methide abstraction. This reactivity pattern is similar to reactions of organometallics with the proposed strong Lewis acid sites present on Al2 O3 ., (© 2022 Wiley-VCH GmbH.)- Published
- 2022
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46. Editorial: Cognitive and Behavioral Features in ALS: Beyond Motor Impairment in ALS-FTD Spectrum Disorders.
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Bersano E, Manera U, and Huynh W
- Abstract
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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- 2022
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47. Prognostic indicators of subacute combined degeneration from B12 deficiency: A systematic review.
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Jhunjhnuwala D, Tanglay O, Briggs NE, Yuen MTY, and Huynh W
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- Humans, Magnetic Resonance Imaging, Prognosis, Vitamin B 12 therapeutic use, Subacute Combined Degeneration diagnosis, Vitamin B 12 Deficiency complications, Vitamin B 12 Deficiency diagnosis, Vitamin B 12 Deficiency drug therapy
- Abstract
Objective: A systematic review was conducted on published data of subacute combined degeneration (SCD) from B12 deficiency to investigate potential prognostic indicators of final ambulatory function in affected patients. TYPE: Systematic review., Literature Survey: Records published from 1999 through 2018 were searched on the electronic databases MEDLINE, PUBMED, and SCOPUS. The publication language was restricted to English and French., Methodology: Records that described cases of SCD from B12 deficiency in patients ≥16 years of age at onset were included. From a final total of 66 cases of SCD identified, ambulation scores were assigned based on the clinical descriptions reported. Patient characteristics, clinical manifestations, and ambulatory function were reported descriptively. Subanalyses on potential prognostic indicators were performed., Synthesis: Greater ambulatory function at diagnosis was associated with recovery of normal ambulatory function at follow-up (P < .001). Nearly 90% of patients walking unsupported at diagnosis made a complete recovery regardless of etiology. For patients initially walking with support, 22% of cases from impaired B12 digestion/absorption made a complete recovery compared with ≥50% of cases from other etiologies. For patients initially requiring a wheelchair, 33% of cases from impaired digestion/absorption were able to walk with support compared with ≥50% of cases from other etiologies. The total B12 administered over the course of treatment was correlated with improved ambulation (P = .024) for all patients, with a higher B12 replacement regimen associated with better outcomes in patients who were unable to walk unsupported at diagnosis (number needed to treat = 4)., Conclusions: Initial ambulatory function may be a useful clinical marker of the severity of spinal cord dysfunction and final functional outcome. Etiological risk factors influenced both clinical manifestations and final walking ability in SCD, suggesting a distinct pathophysiological mechanism among the causes. In addition, a more intensive B12 replacement regimen may improve ultimate ambulatory function in advanced cases of SCD., (© 2021 American Academy of Physical Medicine and Rehabilitation.)
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- 2022
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48. The changing landscape of neuroimaging in frontotemporal lobar degeneration: from group-level observations to single-subject data interpretation.
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McKenna MC, Murad A, Huynh W, Lope J, and Bede P
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- Brain diagnostic imaging, Humans, Magnetic Resonance Imaging methods, Neuroimaging, Frontotemporal Dementia, Frontotemporal Lobar Degeneration diagnostic imaging
- Abstract
Introduction: While the imaging signatures of frontotemporal lobar degeneration (FTLD) phenotypes and genotypes are well-characterized based on group-level descriptive analyses, the meaningful interpretation of single MRI scans remains challenging. Single-subject MRI classification frameworks rely on complex computational models and large training datasets to categorize individual patients into diagnostic subgroups based on distinguishing imaging features. Reliable individual subject data interpretation is hugely important in the clinical setting to expedite the diagnosis and classify individuals into relevant prognostic categories., Areas Covered: This article reviews (1) single-subject MRI classification strategies in symptomatic and pre-symptomatic FTLD, (2) practical clinical implications, and (3) the limitations of current single-subject data interpretation models., Expert Opinion: Classification studies in FTLD have demonstrated the feasibility of categorizing individual subjects into diagnostic groups based on multiparametric imaging data. Preliminary data indicate that pre-symptomatic FTLD mutation carriers may also be reliably distinguished from controls. Despite momentous advances in the field, significant further improvements are needed before these models can be developed into viable clinical applications.
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- 2022
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49. Isospin magnetism and spin-polarized superconductivity in Bernal bilayer graphene.
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Zhou H, Holleis L, Saito Y, Cohen L, Huynh W, Patterson CL, Yang F, Taniguchi T, Watanabe K, and Young AF
- Abstract
In conventional superconductors, Cooper pairing occurs between electrons of opposite spin. We observe spin-polarized superconductivity in Bernal bilayer graphene when doped to a saddle-point van Hove singularity generated by large applied perpendicular electric field. We observe a cascade of electrostatic gate-tuned transitions between electronic phases distinguished by their polarization within the isospin space defined by the combination of the spin and momentum-space valley degrees of freedom. Although all of these phases are metallic at zero magnetic field, we observe a transition to a superconducting state at finite B
‖ ≈ 150mT applied parallel to the two-dimensional sheet. Superconductivity occurs near a symmetry breaking transition, and exists exclusively above the B‖ -limit expected of a paramagnetic superconductor with the observed transition temperature TC ≈ 30mK, consistent with a spin-triplet order parameter.- Published
- 2022
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50. Apathy is associated with parietal cortical-subcortical dysfunction in ALS.
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Caga J, Tu S, Dharmadasa T, Tse NY, Zoing MC, Huynh W, Mahoney C, Ahmed RM, and Kiernan MC
- Subjects
- Emotions, Humans, Quality of Life, Amyotrophic Lateral Sclerosis, Apathy, Frontotemporal Dementia
- Abstract
Apathy is the core behavioural feature of frontotemporal dysfunction in amyotrophic lateral sclerosis (ALS). Initiation and emotional manifestations of apathy significantly affect patients and carers, particularly in terms of quality of life. As such, the primary aim of the present study was to investigate the prevalence and neural correlates of initiation, and emotional subtypes of apathy in ALS. A total of 109 participants were recruited from a specialised, tertiary referral ALS/FTD clinic. Overall rates of apathy, including cognitive, initiation and emotion subtypes as assessed by the Dimensional Apathy Scale (DAS), were examined and correlated with brain volumes, including voxel-based morphometry on high resolution MRI. Clinically significant apathy ranged between 49% (patient-rated DAS) and 64% (carer-rated DAS), with the most common apathy subtypes being initiation (84-96%) and emotional (74-75%) apathy. The results of the two-way repeated measures ANOVA revealed significant differences across the DAS executive, emotional and initiation subscales (p = .0001). Multivariate analysis using a logistic regression model showed that only initiation; (odds ratio = 3.08, p = .004) and emotional (odds ratio = 2.40, p = .008) apathy were predictive of clinically significant apathy, controlling for education and depression. Increased initiation apathy correlated with reduced grey matter within bilateral superior frontal gyrus and increased emotional apathy correlated with reduced grey matter in prefrontal cortices and right anterior cingulate, previously implicated in apathy. Additional correlations were identified including the angular gyrus (or the temporo-parietal junction), important in reward valuation and subsequent goal-directed behaviour. Taken together, results from the present series highlight the frequency and multi-dimensionality of apathy in ALS. The pathophysiological mechanisms of apathy in ALS may be critically underpinned by neurodegeneration across a distributed brain network, with key roles in task initiation, emotion, reward processing and subsequent goal-directed behaviour., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
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