Search

Your search keyword '"Huynh, Do Luong"' showing total 23 results
Start Over Author "Huynh, Do Luong"
23 results on '"Huynh, Do Luong"'

14. MicroRNA-128 suppresses paclitaxel-resistant lung cancer by inhibiting MUC1-C and BMI-1 in cancer stem cells

Author

Koh, Hyebin, primary, Park, Hyeri, additional, Chandimali, Nisansala, additional, Huynh, Do Luong, additional, Zhang, Jiao Jiao, additional, Ghosh, Mrinmoy, additional, Gera, Meeta, additional, Kim, Nameun, additional, Bak, Yesol, additional, Yoon, Do-Young, additional, Park, Yang Ho, additional, Kwon, Taeho, additional, and Jeong, Dong Kee, additional

Published
2017
Full Text
View/download PDF

15. A PiggyBac mediated approach for lactoferricin gene transfer in bovine mammary epithelial stem cells for management of bovine mastitis

Author

Sharma, Neelesh, primary, Huynh, Do Luong, additional, Kim, Sung Woo, additional, Ghosh, Mrinmoy, additional, Sodhi, Simrinder Singh, additional, Singh, Amit Kumar, additional, Kim, Nam Eun, additional, Lee, Sung Jin, additional, Hussain, Kafil, additional, Oh, Sung Jong, additional, and Jeong, Dong Kee, additional

Published
2017
Full Text
View/download PDF

19. Novel phyto-derivative BRM270 inhibits hepatocellular carcinoma cells proliferation by inducing G2/M phase cell cycle arrest and apoptosis in xenograft mice model

Author

Kumar Mongre, Raj, primary, Sharma, Neelesh, additional, Singh Sodhi, Simrinder, additional, Ghosh, Mrinmoy, additional, Kumar Singh, Amit, additional, Kim, Nameun, additional, Park, Yang Ho, additional, Shin, Young Gyu, additional, Kim, Sung Jin, additional, Jiao Jiao, Zhang, additional, Huynh, Do Luong, additional, and Jeong, Dong Kee, additional

Published
2017
Full Text
View/download PDF

21. Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-κB inhibitor BRM270 in a xenograft model of lung adenocarcinoma

Author

MONGRE, RAJ KUMAR, primary, SODHI, SIMRINDER SINGH, additional, SHARMA, NEELESH, additional, GHOSH, MRINMOY, additional, KIM, JEONG HYUN, additional, KIM, NAMEUN, additional, PARK, YANG HO, additional, SHIN, YOUNG GYU, additional, KIM, SUNG JIN, additional, JIAO, ZHANG JIAO, additional, HUYNH, DO LUONG, additional, and JEONG, DONG KEE, additional

Published
2015
Full Text
View/download PDF

22. Innovative Approach of Non-Thermal Plasma Application for Improving the Growth Rate in Chickens.

Author

Zhang, Jiao Jiao, Wang, Xian Zhong, Kwon, Taeho, Huynh, Do Luong, Chandimali, Nisansala, Kim, Nameun, Kang, Tae Yoon, Ghosh, Mrinmoy, Gera, Meeta, Lee, Sang Baek, Lee, Sung Jin, Lee, Wang Shik, Kim, Seong Bong, Mok, Young Sun, and Jeong, Dong Kee

Subjects
NON-thermal plasmas, LIVESTOCK development, GROWTH rate, EGGS, REACTIVE oxygen species
Abstract

As an innovative technology in biological applications—non-thermal plasma technique—has recently been applied to living cells and tissues. However, it is unclear whether non-thermal plasma treatment can directly regulate the growth and development of livestock. In this study, we exposed four-day-incubated fertilized eggs to plasma at 11.7 kV for 2 min, which was found to be the optimal condition in respect of highest growth rate in chickens. Interestingly, plasma-treated male chickens conspicuously grew faster than females. Plasma treatment regulated the reactive oxygen species homeostasis by controlling the mitochondrial respiratory complex activity and up-regulating the antioxidant defense system. At the same time, growth metabolism was improved due to the increase of growth hormone and insulin-like growth factor 1 and their receptors expression, and the rise of thyroid hormones and adenosine triphosphate levels through the regulation of demethylation levels of growth and hormone biosynthesis-related genes in the skeletal muscles and thyroid glands. To our knowledge, this study was the first to evaluate the effects of a non-thermal plasma treatment on the growth rate of chickens. This safe strategy might be beneficial to the livestock industry. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

23. Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-κB inhibitor BRM270 in a xenograft model of lung adenocarcinoma.

Author

Mongre RK, Sodhi SS, Sharma N, Ghosh M, Kim JH, Kim N, Park YH, Shin YG, Kim SJ, Jiao ZJ, Huynh do L, and Jeong DK

Subjects
Acute-Phase Proteins biosynthesis, Adenocarcinoma pathology, Adenocarcinoma of Lung, Animals, Apoptosis drug effects, Cell Line, Tumor, Doxorubicin administration & dosage, Drugs, Chinese Herbal administration & dosage, Epigenesis, Genetic genetics, Gene Expression Regulation, Neoplastic drug effects, Humans, Lipocalin-2, Lipocalins biosynthesis, Lung Neoplasms pathology, Mice, NF-kappa B genetics, Neoplasm Metastasis, Proto-Oncogene Proteins biosynthesis, Xenograft Model Antitumor Assays, Acute-Phase Proteins genetics, Adenocarcinoma genetics, Carcinogenesis genetics, Drug Resistance, Neoplasm genetics, Epithelial-Mesenchymal Transition genetics, Lipocalins genetics, Lung Neoplasms genetics, Proto-Oncogene Proteins genetics
Abstract

Tumor initiating cancer stem-like cells (TICSCs) have recently become the object of intensive study. Human-Lipocalin-2 (hLCN2) acts as a biomarker for cancers. The aim of the present study was to explore new insights regarding the potential role of LCN2 in inducing epithelial to mesenchymal transition (EMT) by transfecting LCN2 into CD133+-A549-TICSCs and its cross-talk with the NF-κB signaling pathway in adenocarcinoma of the lung. Furthermore, EMT was confirmed by transcriptomic analysis, immunoblotting and immunocyto/histochemical analyses. Tumorigenesis and metastasis were confirmed by molecular therapeutics tracer 2DG infrared optical probe in BALB/cSIc-nude mice. It was observed that the CD133+-expressing-LCN2-A549 TICSCs population increased in adenocarcinoma of the lung compared to the normal lung tissue. The expressions of genes involved in stemness, adhesion, motility and drug efflux was higher in these cells than in their non-LCN2 expressing counterparts. The present study revealed that elevated expression of LCN2 significantly induced metastasis via EMT. Overexpression of LCN2 significantly increased stemness and tumor metastasis by modulating NF-κB cellular signaling. BRM270, a novel inhibitor of NF-κB plays a significant role in the EMT reversal. BRM270, a naturaceutical induces cell shrinkage, karyorrhexis and programmed cell death (PCD) which were observed by Hoechst 33342 staining while flow cytometry analysis showed significant (P<0.05) decrease in cell population from G0-G1 phases. Also, 2DG guided in vivo model revealed that BRRM270 significantly (P<0.0003) reduced tumor metastasis and increased percent survival in real-time with complete resection. An elaborate study on the novel concept with respect to linking of naturaceutics as selective and potential anticancer agent that eliminates the elevated LCN2 induced EMT and tumor dissemination through cooperation with the NF-κB signaling as the baseline data for the planning of new therapeutic strategies was conducted for the first time. Our results also illustrate a molecular mechanistic approach for 2DG-guided molecular imaging-based cancer therapy using BRM270 as a novel cancer therapeutic drug to enhance the effect of doxorubicin (Dox)-resistant LCN2 induced metastasis of solid tumors in nude mice.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results