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17. VER EECKE, Wilfried. Breaking through Schizophrenia

Author

Hutchinson, Thomas

Subjects
Breaking Through Schizophrenia (Nonfiction work) -- Ver Eecke, Wilfried -- Book reviews, Philosophy and religion
Abstract

VER EECKE, Wilfried. Breaking through Schizophrenia. London: Rowman & Littlefield, 2019. 269 pp. Paper, $55.00--Wilfried Ver Eecke's Breaking through Schizophrenia is a fitting title. It breaks through disciplinary barriers befitting [...]

Published
2020

22. Design, Synthesis, and Activity of a Series of Arylpyrid-3-ylmethanones as Type I Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors

Author

Hogenkamp, Derk J, Ford-Hutchinson, Thomas A, Li, Wen-Yen, Whittemore, Edward R, Yoshimura, Ryan F, Tran, Minhtam B, Johnstone, Timothy BC, Bascom, Gavin D, Rollins, Hannah, Lu, Lena, and Gee, Kelvin W

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Neurosciences, Behavioral and Social Science, Brain Disorders, Mental Health, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Allosteric Regulation, Animals, Binding Sites, Dose-Response Relationship, Drug, Drug Design, Humans, Mice, Molecular Structure, Oocytes, Pyridines, Structure-Activity Relationship, Xenopus, alpha7 Nicotinic Acetylcholine Receptor, Organic Chemistry, Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry, Organic chemistry
Abstract

A series of novel arylpyrid-3-ylmethanones (7a-aa) were designed as modulators of α7 nicotinic acetylcholine receptors (nAChRs). The methanones were found to be type I positive allosteric modulators (PAMs) of human α7 nAChRs expressed in Xenopus ooctyes. Structure-activity relationship (SAR) studies resulted in the identification of compound 7v as a potent and efficacious type I PAM with maximum modulation of a nicotine EC5 response of 1200% and EC50 = 0.18 μM. Compound 7z was active in reversing the effect of scopolamine in the novel object recognition (NOR) paradigm with a minimum effective ip dose of 1.0 mg/kg (2.7 μmol/kg). This effect was blocked by the selective α7 nAChR antagonist methyllycaconitine (MLA). These compounds are potent type I positive allosteric modulators of α7 nAChRs that may have therapeutic value in restoring impaired sensory gating and cognitive deficits in schizophrenia and Alzheimer's disease.

Published
2013

31. Development and validation of an OECD reproductive toxicity test guideline with the mudsnail Potamopyrgus antipodarum (Mollusca, Gastropoda)

Author

Ruppert, Katharina, Geiß, Cornelia, Askem, Clare, Benstead, Rachel, Brown, Rebecca, Coke, Maira, Ducrot, Virginie, Egeler, Philipp, Holbech, Henrik, Hutchinson, Thomas H., Kinnberg, Karin L., Lagadic, Laurent, Le Page, Gareth, Macken, Ailbhe, Matthiessen, Peter, Ostermann, Sina, Schimera, Agnes, Schmitt, Claudia, Seeland-Fremer, Anne, Smith, Andy J., Weltje, Lennart, and Oehlmann, Jörg

Published
2017
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34. Optimizing the design of a reproduction toxicity test with the pond snail Lymnaea stagnalis

Author

Charles, Sandrine, Ducrot, Virginie, Azam, Didier, Benstead, Rachel, Brettschneider, Denise, De Schamphelaere, Karel, Filipe Goncalves, Sandra, Green, John W., Holbech, Henrik, Hutchinson, Thomas H., Faber, Daniel, Laranjeiro, Filipe, Matthiessen, Peter, Norrgren, Leif, Oehlmann, Jörg, Reategui-Zirena, Evelyn, Seeland-Fremer, Anne, Teigeler, Matthias, Thome, Jean-Pierre, Tobor Kaplon, Marysia, Weltje, Lennart, and Lagadic, Laurent

Published
2016
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36. The effects of environmental contaminants on the immune functions of marine flatfish

Author

Hutchinson, Thomas Henry

Subjects
636.089, Fish immunology
Abstract

Given the widespread concern that chemical contaminants may be associated with infectious disease outbreaks in marine fish populations, work has been undertaken with the aim of developing a suite of non-specific and specific assays of marine fish immune function and the application of these techniques in a variety of field and laboratory investigations. Most of the work focused on dab, Limanda limanda (L.) in view of the importance of this species in several North Sea fish disease monitoring programmes, and was also supplemented with investigations of specific immune function in turbot, Scopthalmus maximus (L.). Initial field studies examined non-specific immune function in terms of lymphoid organ morphology in dab sampled along a North Sea gradient of chemical contamination during the March 1990 ICES/IOC Bremerhaven workshop. Significant differences were observed in the kidney and spleen cell populations from dab, and these observations were considered in view of the various other physico-chemical and biological results generated during the Bremerhaven workshop. Following the valuable experience gained of the practical aspects of the field monitoring approach, laboratory investigations were initiated with the aim of developing a suite of immune function assays for deployment in either laboratory or field studies of marine fish health. Assays for non-specific immune functions were considered, including serum protein and lysozyme levels, methods of phagocyte collection, phagocyte chemiluminescence, calorimetric detection of individual reactive oxygen species and in vitro cell migration assays. Additional field work was undertaken, with the monitoring of serum total protein levels and lysozyme activity in dab sampled from Lyme Bay, UK This study provided evidence of a marked seasonal variation in non-specific immune function, which appeared to be associated with environmental factors (e.g. water temperature) and the reproductive cycle. Selected non-specific assays were applied to dab and turbot exposed under controlled laboratory conditions to a variety of important marine contaminants, including cadmium, polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs), and the biological data integrated with appropriate chemical characterisation of the exposure matrix. Using cultured turbot as a test species, the non-specific assays were also supplemented with the assay of specific immune function in fish exposed to PCB contaminated sediments. In brief, there was evidence of significant impairment of immune function in fish exposed to either individual contaminants (viz. cadmium and PAHs) or contaminant mixtures (viz. PAHs and PCBs) under the laboratory conditions described. In summary, the project was successful in its primary aims of developing a suite of techniques for evaluating both cellular and humoral immune functions in marine flatfish, and applying these techniques in the laboratory to assess the impact of important classes of environmental contaminants on fish health. Selected techniques were also used in field monitoring studies of marine fish immune function, illustrating the potential of such techniques for use in future laboratory and field studies of fish health.

Published
1996

38. New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians

Author

Mitchell, Constance A., primary, Burden, Natalie, additional, Bonnell, Mark, additional, Hecker, Markus, additional, Hutchinson, Thomas H., additional, Jagla, Magdalena, additional, LaLone, Carlie A., additional, Lagadic, Laurent, additional, Lynn, Scott G., additional, Shore, Bryon, additional, Song, You, additional, Vliet, Sara M., additional, Wheeler, James R., additional, and Embry, Michelle R., additional

Published
2023
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39. Validation of the OECD reproduction test guideline with the New Zealand mudsnail Potamopyrgus antipodarum using trenbolone and prochloraz

Author

Geiß, Cornelia, Ruppert, Katharina, Askem, Clare, Barroso, Carlos, Faber, Daniel, Ducrot, Virginie, Holbech, Henrik, Hutchinson, Thomas H., Kajankari, Paula, Kinnberg, Karin Lund, Lagadic, Laurent, Matthiessen, Peter, Morris, Steve, Neiman, Maurine, Penttinen, Olli-Pekka, Sanchez-Marin, Paula, Teigeler, Matthias, Weltje, Lennart, and Oehlmann, Jörg

Published
2017
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42. Development and validation of an OECD reproductive toxicity test guideline with the pond snail Lymnaea stagnalis (Mollusca, Gastropoda)

Author

Ducrot, Virginie, Askem, Clare, Azam, Didier, Brettschneider, Denise, Brown, Rebecca, Charles, Sandrine, Coke, Maïra, Collinet, Marc, Delignette-Muller, Marie-Laure, Forfait-Dubuc, Carole, Holbech, Henrik, Hutchinson, Thomas, Jach, Arne, Kinnberg, Karin L., Lacoste, Cédric, Le Page, Gareth, Matthiessen, Peter, Oehlmann, Jörg, Rice, Lynsey, Roberts, Edward, Ruppert, Katharina, Davis, Jessica Elphinstone, Veauvy, Clemence, Weltje, Lennart, Wortham, Ruth, and Lagadic, Laurent

Published
2014
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45. Case Study – When A Roof is More Than a Roof

Author

Hutchinson Thomas W.

Subjects
Environmental sciences, GE1-350
Abstract

The repurposing of existing buildings is becoming more prevalent. But changing a buildings use is not without concern. A European Company purchased an existing warehouse located north of Chicago, Illinois, USA as the space filled their needs for the layout of their manufacturing equipment. Producing medical grade synthetic mesh requires interior temperatures of 90°F (32.2C) with a relative humidity of 90%. The roof of the facility was low-sloped trapezoidal standing seam metal roof system that was watertight in all types of precipitation: Rain, snow, ice. The insulation, below the roof panels and above the steel purlins, was vinyl face fiberglass batt laid over the structural steel bar joist and pinned by the metal roof panels. Shortly after manufacturing commenced, water build-up in the batt insulation during winter started and was so severe that the vinyl facing would belly downward and split the lap seams, which would release the water, soiling the 2m wide rolls of mesh that then did not meet medical standards and had to be discarded. This case study will review the issues that arose out of repurposing a warehouse to a manufacturing facility and what the solution to correct moisture related issues. Hutchinson Design Group, Ltd. of Barrington, Illinois, was retained to investigate the conditions, determine the causes and develop a corrective solution.

Published
2020
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