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372 results on '"Hutchinson, Ryan"'

1. A tumor focused approach to resolving the etiology of DNA mismatch repair deficient tumors classified as suspected Lynch syndrome

Author

Walker, Romy, Mahmood, Khalid, Joo, Jihoon E., Clendenning, Mark, Georgeson, Peter, Como, Julia, Joseland, Sharelle, Preston, Susan G., Antill, Yoland, Austin, Rachel, Boussioutas, Alex, Bowman, Michelle, Burke, Jo, Campbell, Ainsley, Daneshvar, Simin, Edwards, Emma, Gleeson, Margaret, Goodwin, Annabel, Harris, Marion T., Henderson, Alex, Higgins, Megan, Hopper, John L., Hutchinson, Ryan A., Ip, Emilia, Isbister, Joanne, Kasem, Kais, Marfan, Helen, Milnes, Di, Ng, Annabelle, Nichols, Cassandra, O’Connell, Shona, Pachter, Nicholas, Pope, Bernard J., Poplawski, Nicola, Ragunathan, Abiramy, Smyth, Courtney, Spigelman, Allan, Storey, Kirsty, Susman, Rachel, Taylor, Jessica A., Warwick, Linda, Wilding, Mathilda, Williams, Rachel, Win, Aung K., Walsh, Michael D., Macrae, Finlay A., Jenkins, Mark A., Rosty, Christophe, Winship, Ingrid M., and Buchanan, Daniel D.

Published
2023
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3. Rare germline variants in the AXIN2 gene in families with colonic polyposis and colorectal cancer

Author

Chan, James M., Clendenning, Mark, Joseland, Sharelle, Georgeson, Peter, Mahmood, Khalid, Walker, Romy, Como, Julia, Joo, Jihoon E., Preston, Susan, Hutchinson, Ryan A., Pope, Bernard J., Metz, Andrew, Beard, Catherine, Purvis, Rebecca, Arnold, Julie, Vijay, Varnika, Konycheva, Galina, Atkinson, Nathan, Parry, Susan, Jenkins, Mark A., Macrae, Finlay A., Rosty, Christophe, Winship, Ingrid M., and Buchanan, Daniel D.

Published
2022
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4. Evaluating Multiple Next-Generation Sequencing–Derived Tumor Features to Accurately Predict DNA Mismatch Repair Status

Author

Walker, Romy, Georgeson, Peter, Mahmood, Khalid, Joo, Jihoon E., Makalic, Enes, Clendenning, Mark, Como, Julia, Preston, Susan, Joseland, Sharelle, Pope, Bernard J., Hutchinson, Ryan A., Kasem, Kais, Walsh, Michael D., Macrae, Finlay A., Win, Aung K., Hopper, John L., Mouradov, Dmitri, Gibbs, Peter, Sieber, Oliver M., O'Sullivan, Dylan E., Brenner, Darren R., Gallinger, Steven, Jenkins, Mark A., Rosty, Christophe, Winship, Ingrid M., and Buchanan, Daniel D.

Published
2022
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5. MSH2-deficient prostate tumours have a distinct immune response and clinical outcome compared to MSH2-deficient colorectal or endometrial cancer

Author

McCoy, Patrick, Mangiola, Stefano, Macintyre, Geoff, Hutchinson, Ryan, Tran, Ben, Pope, Bernard, Georgeson, Peter, Hong, Matthew K. H., Kurganovs, Natalie, Lunke, Sebastian, Clarkson, Michael J., Cmero, Marek, Kerger, Michael, Stuchbery, Ryan, Chow, Ken, Haviv, Izhak, Ryan, Andrew, Costello, Anthony J., Corcoran, Niall M., and Hovens, Christopher M.

Published
2021
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6. Androgen Receptor Variants Mediate DNA Repair after Prostate Cancer Irradiation

Author

Yin, Yi, Li, Rui, Xu, Kangling, Ding, Sentai, Li, Jeffrey, Baek, GuemHee, Ramanand, Susmita G, Ding, Sam, Liu, Zhao, Gao, Yunpeng, Kanchwala, Mohammed S, Li, Xiangyi, Hutchinson, Ryan, Liu, Xihui, Woldu, Solomon L, Xing, Chao, Desai, Neil B, Feng, Felix Y, Burma, Sandeep, de Bono, Johann S, Dehm, Scott M, Mani, Ram S, Chen, Benjamin PC, and Raj, Ganesh V

Subjects
Urologic Diseases, Genetics, Prostate Cancer, Aging, Cancer, 2.1 Biological and endogenous factors, Aetiology, Androgen Antagonists, Animals, Antineoplastic Agents, Benzamides, DNA Repair, DNA-Activated Protein Kinase, Humans, Male, Mice, Mice, Nude, Nitriles, Phenylthiohydantoin, Prostatic Neoplasms, Protein Kinase Inhibitors, Radiation, Ionizing, Receptors, Androgen, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

In prostate cancer, androgen deprivation therapy (ADT) enhances the cytotoxic effects of radiotherapy. This effect is associated with weakening of the DNA damage response (DDR) normally supported by the androgen receptor. As a significant number of patients will fail combined ADT and radiotherapy, we hypothesized that DDR may be driven by androgen receptor splice variants (ARV) induced by ADT. Investigating this hypothesis, we found that ARVs increase the clonogenic survival of prostate cancer cells after irradiation in an ADT-independent manner. Notably, prostate cancer cell irradiation triggers binding of ARV to the catalytic subunit of the critical DNA repair kinase DNA-PK. Pharmacologic inhibition of DNA-PKc blocked this interaction, increased DNA damage, and elevated prostate cancer cell death after irradiation. Our findings provide a mechanistic rationale for therapeutic targeting of DNA-PK in the context of combined ADT and radiotherapy as a strategy to radiosensitize clinically localized prostate cancer. Cancer Res; 77(18); 4745-54. ©2017 AACR.

Published
2017

12. The Existence of Strongly-MDS Convolutional Codes

Author

Hutchinson, Ryan

Subjects
Mathematics - Optimization and Control, Computer Science - Information Theory, 94B10
Abstract

It is known that maximum distance separable and maximum distance profile convolutional codes exist over large enough finite fields of any characteristic for all parameters $(n,k,\delta)$. It has been conjectured that the same is true for convolutional codes that are strongly maximum distance separable. Using methods from linear systems theory, we resolve this conjecture by showing that, over a large enough finite field of any characteristic, codes which are simultaneously maximum distance profile and strongly maximum distance separable exist for all parameters $(n,k,\delta)$., Comment: 17 pages

Published
2007

17. Data from Androgen Receptor Variants Mediate DNA Repair after Prostate Cancer Irradiation

Author

Yin, Yi, primary, Li, Rui, primary, Xu, Kangling, primary, Ding, Sentai, primary, Li, Jeffrey, primary, Baek, GuemHee, primary, Ramanand, Susmita G., primary, Ding, Sam, primary, Liu, Zhao, primary, Gao, Yunpeng, primary, Kanchwala, Mohammed S., primary, Li, Xiangyi, primary, Hutchinson, Ryan, primary, Liu, Xihui, primary, Woldu, Solomon L., primary, Xing, Chao, primary, Desai, Neil B., primary, Feng, Felix Y., primary, Burma, Sandeep, primary, de Bono, Johann S., primary, Dehm, Scott M., primary, Mani, Ram S., primary, Chen, Benjamin P.C., primary, and Raj, Ganesh V., primary

Published
2023
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18. Figure S1 from Androgen Receptor Variants Mediate DNA Repair after Prostate Cancer Irradiation

Author

Yin, Yi, primary, Li, Rui, primary, Xu, Kangling, primary, Ding, Sentai, primary, Li, Jeffrey, primary, Baek, GuemHee, primary, Ramanand, Susmita G., primary, Ding, Sam, primary, Liu, Zhao, primary, Gao, Yunpeng, primary, Kanchwala, Mohammed S., primary, Li, Xiangyi, primary, Hutchinson, Ryan, primary, Liu, Xihui, primary, Woldu, Solomon L., primary, Xing, Chao, primary, Desai, Neil B., primary, Feng, Felix Y., primary, Burma, Sandeep, primary, de Bono, Johann S., primary, Dehm, Scott M., primary, Mani, Ram S., primary, Chen, Benjamin P.C., primary, and Raj, Ganesh V., primary

Published
2023
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19. Evaluating Multiple Next-Generation Sequencing–Derived Tumor Features to Accurately Predict DNA Mismatch Repair Status

Author

Walker, Romy, primary, Georgeson, Peter, additional, Mahmood, Khalid, additional, Joo, Jihoon E., additional, Makalic, Enes, additional, Clendenning, Mark, additional, Como, Julia, additional, Preston, Susan, additional, Joseland, Sharelle, additional, Pope, Bernard J., additional, Hutchinson, Ryan A., additional, Kasem, Kais, additional, Walsh, Michael D., additional, Macrae, Finlay A., additional, Win, Aung K., additional, Hopper, John L., additional, Mouradov, Dmitri, additional, Gibbs, Peter, additional, Sieber, Oliver M., additional, O'Sullivan, Dylan E., additional, Brenner, Darren R., additional, Gallinger, Steven, additional, Jenkins, Mark A., additional, Rosty, Christophe, additional, Winship, Ingrid M., additional, and Buchanan, Daniel D., additional

Published
2023
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21. Cell signaling activation and extracellular matrix remodeling underpin glioma tumor microenvironment heterogeneity and organization

Author

Dinevska, Marija, primary, Widodo, Samuel S., additional, Furst, Liam, additional, Cuzcano, Lucero, additional, Fang, Yitong, additional, Mangiola, Stefano, additional, Neeson, Paul J., additional, Darcy, Phillip K., additional, Ramsay, Robert G., additional, Hutchinson, Ryan, additional, MacKay, Fabienne, additional, Christie, Michael, additional, Stylli, Stanley S., additional, and Mantamadiotis, Theo, additional

Published
2022
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22. Additional file 1 of A tumor focused approach to resolving the etiology of DNA mismatch repair deficient tumors classified as suspected Lynch syndrome

Author

Walker, Romy, Mahmood, Khalid, Joo, Jihoon E., Clendenning, Mark, Georgeson, Peter, Como, Julia, Joseland, Sharelle, Preston, Susan G., Antill, Yoland, Austin, Rachel, Boussioutas, Alex, Bowman, Michelle, Burke, Jo, Campbell, Ainsley, Daneshvar, Simin, Edwards, Emma, Gleeson, Margaret, Goodwin, Annabel, Harris, Marion T., Henderson, Alex, Higgins, Megan, Hopper, John L., Hutchinson, Ryan A., Ip, Emilia, Isbister, Joanne, Kasem, Kais, Marfan, Helen, Milnes, Di, Ng, Annabelle, Nichols, Cassandra, O’Connell, Shona, Pachter, Nicholas, Pope, Bernard J., Poplawski, Nicola, Ragunathan, Abiramy, Smyth, Courtney, Spigelman, Allan, Storey, Kirsty, Susman, Rachel, Taylor, Jessica A., Warwick, Linda, Wilding, Mathilda, Williams, Rachel, Win, Aung K., Walsh, Michael D., Macrae, Finlay A., Jenkins, Mark A., Rosty, Christophe, Winship, Ingrid M., and Buchanan, Daniel D.

Abstract

Additional file 1: Table S1. Table displaying optimal cut-offs for the six tumor features determined previously (Walker et al. 2023) in the additive feature combination approach. Table S2. SLS tumors (n=13) that showed discordant MMR IHC findings between clinical diagnostic testing before study entry and testing completed internally during this study and the change in their MMR status and/or pattern of MMR protein loss. Table S3. The concordance between the final MMR IHC result and the predicted dMMR status from the additive feature combination approach overall and by tumor type. Table S4. The tumor MLH1 methylation testing completed for SLS tumors prior to entering the study showing either negative, inconclusive, or not tested results and the subsequent MLH1 methylation testing results from internal testing using MethyLight and MS-HRM assays highlighting the positive MLH1 methylation results found by this study. Table S5. Presentation of germline pathogenic variants and variants of uncertain clinical significance (VUS) identified in the MMR, MUTYH and POLE genes. Table S6. Summary of the clinicopathological features for the double somatic MMR mutation (dMMR-DS) tumors overall and by tumor type. Figure S1. Bar plots presenting the results from the additive tumor feature combination approach to assess the MMR status in the double somatic mutation cohort for A) all tumors combined and separated by B) CRC, C) EC and D) SST tissue types. Figure S2. Bar plot presenting the prevalence of pathogenic/likely pathogenic somatic mutations (including loss of heterozygosity, LOH) by subtype for the study cohort. Figure S3. Pie graphs displaying the frequency of the mutation combination type (two single somatic mutations versus a single somatic mutation with loss of heterozygosity (LOH)) as well as the type of mutation A) overall and B) separated by tissue type. Figure S4. Bar graphs presenting the site distribution in the double somatic mutation cohort across all CRCs and SSTs. Figure S5. Boxplots presenting the site distribution in the double somatic mutation cohort across all A) CRCs and B) SSTs. Significant (< 0.05) p-values are indicated for pairwise (t-test) and multigroup comparisons (Anova). Figure S6. Scatter plots presenting the PREMM5 score distribution in the test cohort for A) all tumors combined and separated by B) CRC, C) EC and D) SST tissue types. Figure S7. The distribution of tumor values for each of the six features that are included in the additive feature combination approach for determining tumor dMMR status grouped by molecular subtype and by combining sporadic dMMR groups dMMR-DS and dMMR-MLH1me into a “sporadic combined” group.

Published
2023
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24. Prognostic Value of PD-1 and PD-L1 Expression in Patients with High Grade Upper Tract Urothelial Carcinoma

Author

Krabbe, Laura-Maria, Heitplatz, Barbara, Preuss, Sina, Hutchinson, Ryan C., Woldu, Solomon L., Singla, Nirmish, Boegemann, Martin, Wood, Christopher G., Karam, Jose A., Weizer, Alon Z., Raman, Jay D., Remzi, Mesut, Rioux-Leclercq, Nathalie, Haitel, Andrea, Rapoport, Leonid M., Glybochko, Peter V., Roscigno, Marco, Bolenz, Christian, Bensalah, Karim, Sagalowsky, Arthur I., Shariat, Shahrokh F., Lotan, Yair, Xylinas, Evanguelos, and Margulis, Vitaly

Published
2017
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25. Evaluating multiple next-generation sequencing derived tumor features to accurately predict DNA mismatch repair status

Author

Walker, Romy, primary, Georgeson, Peter, additional, Mahmood, Khalid, additional, Joo, Jihoon E., additional, Makalic, Enes, additional, Clendenning, Mark, additional, Como, Julia, additional, Preston, Susan, additional, Joseland, Sharelle, additional, Pope, Bernard J., additional, Hutchinson, Ryan, additional, Kasem, Kais, additional, Walsh, Michael D., additional, Macrae, Finlay A., additional, Win, Aung K., additional, Hopper, John L., additional, Mouradov, Dmitri, additional, Gibbs, Peter, additional, Sieber, Oliver M., additional, O’Sullivan, Dylan E., additional, Brenner, Darren R., additional, Gallinger, Steven, additional, Jenkins, Mark A., additional, Rosty, Christophe, additional, Winship, Ingrid M., additional, and Buchanan, Daniel D., additional

Published
2022
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29. Postoperative Nomogram for Relapse-Free Survival in Patients with High Grade Upper Tract Urothelial Carcinoma

Author

Krabbe, Laura-Maria, Eminaga, Okyaz, Shariat, Shahrokh F., Hutchinson, Ryan C., Lotan, Yair, Sagalowsky, Arthur I., Raman, Jay D., Wood, Christopher G., Weizer, Alon Z., Roscigno, Marco, Montorsi, Francesco, Bolenz, Christian, Novara, Giacomo, Kikuchi, Eiji, Fajkovic, Harun, Rapoport, Leonid M., Glybochko, Peter V., Zigeuner, Richard, Remzi, Mesut, Bensalah, Karim, Kassouf, Wassim, and Margulis, Vitaly

Published
2017
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33. Kidney and Ureteral Carcinoma

Author

Wong, William W., primary, Peterson, Jennifer L., additional, Tan, Winston W., additional, Haddock, Michael G., additional, Parker, Alexander S., additional, Wehle, Michael J., additional, and Hutchinson, Ryan C., additional

Published
2016
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34. Contributors

Author

Abrams, Ross A., primary, Adelstein, David J., additional, Alektiar, Kaled M., additional, Alexander, Brian, additional, Alsner, Jan, additional, Altun, Ersan, additional, Anderson, Bethany, additional, Ang, K. Kian, additional, Arthur, Douglas W., additional, Ashman, Jonathan B., additional, Ballo, Matthew T., additional, Barker, Christopher Andrew, additional, Beadle, Beth M., additional, Bedard, Phillipe, additional, Beitler, Jonathan J., additional, Bishop, Michael W., additional, Blackstock, A. William, additional, Bogart, Jeffrey A., additional, Bonner, James A., additional, Bourland, J. Daniel, additional, Bovi, Joseph, additional, Breneman, John, additional, Brito, Juan P., additional, Brown, Paul D., additional, Brundage, Michael D., additional, Buchholz, Thomas A., additional, Burmeister, Bryan Henry, additional, Calderwood, Stuart K., additional, Callister, Matthew D., additional, Calvo, Felipe A., additional, Cannon, George M., additional, Chabner, Bruce A., additional, Chan, Michael D., additional, Chao, Sam T., additional, Charpentier, Anne-Marie, additional, Chung, Christine H., additional, Chung, Peter W.M., additional, Constine, Louis S., additional, Corn, Benjamin W., additional, Covens, Allan, additional, Craciunescu, Oana I., additional, Crane, Christopher H., additional, Creutzberg, Carien L., additional, Crook, Juanita M., additional, Curran, Walter J., additional, Czito, Brian G., additional, Dabaja, Bouthaina S., additional, Das, Shiva, additional, David, Marc, additional, Dawson, Laura A., additional, DeLaney, Thomas F., additional, Devlin, Phillip M., additional, Dewhirst, Mark, additional, Dizon, Don S., additional, Dome, Jeffrey S., additional, Donohue, John H., additional, Duprez, Thierry P., additional, Efstathiou, Jason A., additional, Eisbruch, Avraham, additional, Eisele, David W., additional, Feng, Mary, additional, Fernandes, Rui P., additional, Fielding, Julia R., additional, Fleming, Gini F., additional, Foote, Robert L., additional, Fraass, Benedick A., additional, Freeman, Carolyn R., additional, Garden, Adam S., additional, Gentry, Lindell R., additional, Gien, Lilian T., additional, Gospodarowicz, Mary K., additional, Grau, Cai, additional, Grégoire, Vincent, additional, Greven, Craig M., additional, Greven, Kathryn McConnell, additional, Gunderson, Leonard L., additional, Haddock, Michael G., additional, Halyard, Michele, additional, Hamoir, Marc, additional, Hanna, Timothy Paul, additional, Harari, Paul M., additional, Hay, Ian D., additional, Herman, Joseph M., additional, Holloway, Caroline L., additional, Hong, Theodore Sunki, additional, Horowitz, Neil S., additional, Horseman, Michael R., additional, Howle, Julie, additional, Hrycushko, Brian A., additional, Hsu, David, additional, Hudgins, Patricia A., additional, Hutchinson, Ryan C., additional, Iacobuzio-Donahue, Christine, additional, Izar, Benjamin, additional, Jewells, Valerie L., additional, Jurcic, Joseph Gerard, additional, Kalapurakal, John A., additional, Kavanagh, Brian D., additional, Kelly, Kara M., additional, Khandani, Amir H., additional, Khuntia, Deepak, additional, Kiess, Ana Ponce, additional, Knox, Susan J., additional, Koh, Wui-Jin, additional, Krasin, Matthew J., additional, Kun, Larry E., additional, Laack, Nadia Issa, additional, LaCasce, Ann S., additional, Langer, Corey Jay, additional, Laramore, George E., additional, Lassman, Andrew B., additional, Lawton, Colleen A.F., additional, Lee, Nancy, additional, Lengelé, Benoît, additional, Levin, William P., additional, Lindegaard, Jacob C., additional, Lucas, John T., additional, MacDonald, Shannon M., additional, Mackillop, William J., additional, Mahindra, Anuj, additional, Mancuso, Anthony A., additional, Marcus, Karen Jean, additional, Marks, Lawrence B., additional, Matceyevsky, Diana, additional, Mazeron, Jean-Jacques, additional, McDonald, Mark W., additional, Medin, Paul M., additional, Mehta, Minesh P., additional, Mendenhall, William M., additional, Meredith, Ruby F., additional, Michalski, Jeff M., additional, Milano, Michael T., additional, Minsky, Bruce D., additional, Morrison, William H., additional, Murphy, Erin S., additional, Murthy, Rashmi K., additional, Ng, Andrea K., additional, Nordsmark, Marianne, additional, O'Farrell, Desmond A., additional, Okunieff, Paul, additional, Ove, Roger, additional, Overgaard, Jens, additional, Palta, Manisha, additional, Parker, Alexander S., additional, Pater, Luke E., additional, Peterson, Jennifer L., additional, Pisansky, Thomas M., additional, Potters, Louis, additional, Quon, Harry, additional, Raben, David, additional, Recht, Abram, additional, Rengan, Ramesh, additional, Reyngold, Marsha, Laufer, additional, Riaz, Nadeem, additional, Roberts, Stephen S., additional, Roberts, Kenneth B., additional, Rockhill, Jason K., additional, Rödel, Claus M., additional, Rodriguez-Galindo, Carlos, additional, Rogers, C. Leland, additional, Rosenblat, Todd L., additional, Rule, William G., additional, Russell, Anthony Henryk, additional, Russo, Suzanne, additional, Ryan, David P., additional, Sandlund, John Torsten, additional, Sandow, Pamela L., additional, Sargent, Daniel J., additional, Schild, Steven E., additional, Seegenschmiedt, Michael Heinrich, additional, Shah, Chirag, additional, Shaw, Edward G., additional, Sheehan, Jason P., additional, Sheikh, Arif, additional, Shi, Qian, additional, Siker, Malika L., additional, Small, William, additional, Smith, Benjamin D., additional, Smith, Grace L., additional, Solberg, Timothy D., additional, Stauffer, Paul R., additional, Stevenson, Mary Ann, additional, Stewart, Alexandra J., additional, Suh, John H., additional, Tan, Winston W., additional, Tepper, Joel E., additional, Thomas, Charles R., additional, Thomas, Gillian M., additional, Timmerman, Robert D., additional, Tsang, Richard W., additional, Usuki, Kenneth Y., additional, Valentini, Vincenzo, additional, Valero, Vicente, additional, van den Bent, Martin J., additional, Veness, Michael J., additional, Vicini, Frank A., additional, Vicus, Danielle, additional, Viswanathan, Akila N., additional, Vujaskovic, Zeljko, additional, Wadsworth, J. Trad, additional, Wagner, Henry, additional, Wahl, Daniel R., additional, Warde, Padraig R., additional, Waxweiler, Timothy V., additional, Wehle, Michael J., additional, Weil, Robert J., additional, Weiss, Lawrence M., additional, Werning, John W., additional, Willett, Christopher G., additional, Willey, Christopher Douglas, additional, Wilson, Lynn D., additional, Winkfield, Karen M., additional, Yon-Li, Jennifer, additional, Wolden, Suzanne L., additional, Wong, Terence Z., additional, Wong, Jeffrey Y.C., additional, Wong, William W., additional, Wu, Wenting, additional, Yahalom, Joachim, additional, Yang, Eddy Shih-Hsin, additional, You, Y. Nancy, additional, Zeman, Elaine M., additional, Zeng, Jing, additional, and Zietman, Anthony L., additional

Published
2016
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37. Rare germline variants in the AXIN2 gene in families with colonic polyposis and colorectal cancer

Author

Chan, James M., primary, Clendenning, Mark, additional, Joseland, Sharelle, additional, Georgeson, Peter, additional, Mahmood, Khalid, additional, Walker, Romy, additional, Como, Julia, additional, Joo, Jihoon E., additional, Preston, Susan, additional, Hutchinson, Ryan A., additional, Pope, Bernard J., additional, Metz, Andrew, additional, Beard, Catherine, additional, Purvis, Rebecca, additional, Arnold, Julie, additional, Vijay, Varnika, additional, Konycheva, Galina, additional, Atkinson, Nathan, additional, Parry, Susan, additional, Jenkins, Mark A., additional, Macrae, Finlay A., additional, Rosty, Christophe, additional, Winship, Ingrid M., additional, and Buchanan, Daniel D., additional

Published
2021
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47. PICan: An integromics framework for dynamic cancer biomarker discovery

Author

McArt, Darragh G., Blayney, Jaine K., Boyle, David P., Irwin, Gareth W., Moran, Michael, Hutchinson, Ryan A., Bankhead, Peter, Kieran, Declan, Wang, Yinhai, Dunne, Philip D., Kennedy, Richard D., Mullan, Paul B., Harkin, Paul D., Catherwood, Mark A., James, Jacqueline A., Salto-Tellez, Manuel, and Hamilton, Peter W.

Published
2015
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48. Single‐cell analysis of mouse and human prostate reveals novel fibroblasts with specialized distribution and microenvironment interactions

Author

Joseph, Diya B, primary, Henry, Gervaise H, additional, Malewska, Alicia, additional, Reese, Jeffrey C, additional, Mauck, Ryan J, additional, Gahan, Jeffrey C, additional, Hutchinson, Ryan C, additional, Malladi, Venkat S, additional, Roehrborn, Claus G, additional, Vezina, Chad M, additional, and Strand, Douglas W, additional

Published
2021
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49. Immunohistochemical evaluation of the prognostic and predictive power of epidermal growth factor receptor ligand levels in patients with metastatic colorectal cancer

Author

Siavash Foroughi, Hutchinson, Ryan A., Wong, Hui-Li, Christie, Michael, Ahida Batrouney, Wong, Rachel, Lee, Margaret, Tie, Jeanne, Burgess, Antony Wilks, and Gibbs, Peter

Abstract

For patients with metastatic colorectal cancer (mCRC), epidermal growth factor receptor (EGFR) inhibitors are limited to patients with RAS wild-type tumours. Not all patients will benefit from treatment and better predictive biomarkers are needed. Here we investigated the prognostic and predictive impact of the EGFR ligands amphiregulin (AREG) and epiregulin (EREG). Expression levels were assessed by immunohistochemistry on 99 KRAS wild-type tumours. AREG and EREG positivity was seen in 49% and 50% of cases, respectively. No difference in expression was observed by primary tumour side. There was no significant difference in OS by AREG or EREG expression. In the subset of patients who received an EGFR inhibitor, EREG positivity was associated with longer OS (median 34.0 vs. 27.0 months, p = 0.033), driven by a difference in patients with a left-sided primary (HR 0.37, p = 0.015). Our study supports further investigation into EREG as a predictive biomarker in mCRC.

Published
2021
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50. sj-docx-1-isp-10.1177_00207640211057727 ��� Supplemental material for How effective is group intervention in the treatment for unaccompanied and accompanied refugee minors with mental health difficulties: A systematic review

Author

Hutchinson, Ryan, King, Natalie, and Majumder, Pallab

Subjects
FOS: Psychology, FOS: Clinical medicine, education, food and beverages, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-1-isp-10.1177_00207640211057727 for How effective is group intervention in the treatment for unaccompanied and accompanied refugee minors with mental health difficulties: A systematic review by Ryan Hutchinson, Natalie King and Pallab Majumder in International Journal of Social Psychiatry

Published
2021
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