Search

Your search keyword '"Hussey H"' showing total 419 results
Start Over Author "Hussey H"
419 results on '"Hussey H"'

2. Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa

Author

Davies, M-A, Kassanjee, R, Rosseau, P, Morden, E, Johnson, L, Solomon, W, Hsiao, N-Y, Hussey, H, Meintjes, G, Paleker, M, Jacobs, T, Raubenheimer, P, Heekes, A, Dane, P, Bam, J-L, Smith, M, Preiser, W, Pienaar, D, Mendelson, M, Naude, J, Schrueder, N, Mnguni, A, Roux, SL, Murie, K, Prozesky, H, Mahomed, H, Rossouw, L, Wasserman, S, Maughan, D, Boloko, L, Smith, B, Taljaard, J, Symons, G, Ntusi, N, Parker, A, Wolter, N, Jassat, W, Cohen, C, Lessells, R, Wilkinson, RJ, Arendse, J, Kariem, S, Moodley, M, Vallabhjee, K, Wolmarans, M, Cloete, K, Boulle, A, and Wellcome Trust

Subjects
Model organisms, Adult, Male, sub-Saharan Africa, 2ND WAVES, COVID-19 Vaccines, Omicron, Immunology, VARIANT, Infectious Disease, 1ST, Article, 1117 Public Health and Health Services, Cohort Studies, South Africa, Young Adult, COVID-19 Testing, Seroepidemiologic Studies, Tropical Medicine, Humans, prior infection, Public, Environmental & Occupational Health, Human Biology & Physiology, Science & Technology, Clinical Laboratory Techniques, SARS-CoV-2, FOS: Clinical medicine, Public Health, Environmental and Occupational Health, COVID-19, vaccination, immunity, Infectious Diseases, Delta, Western Cape and South African National Departments of Health in collaboration with the National Institute for Communicable Diseases in South Africa Affiliations, Parasitology, Female, Life Sciences & Biomedicine
Abstract

Objectives: We aimed to compare COVID-19 outcomes in the Omicron-driven fourth wave with prior waves in the Western Cape, the contribution of undiagnosed prior infection to differences in outcomes in a context of high seroprevalence due to prior infection, and whether protection against severe disease conferred by prior infection and/or vaccination was maintained. Methods: In this cohort study, we included public sector patients aged ≥20 years with a laboratory confirmed COVID-19 diagnosis between 14 November-11 December 2021 (wave four) and equivalent prior wave periods. We compared the risk between waves of the following outcomes using Cox regression: death, severe hospitalization or death and any hospitalization or death (all ≤14 days after diagnosis) adjusted for age, sex, comorbidities, geography, vaccination and prior infection. Results: We included 5,144 patients from wave four and 11,609 from prior waves. Risk of all outcomes was lower in wave four compared to the Delta-driven wave three (adjusted Hazard Ratio (aHR) [95% confidence interval (CI)] for death 0.27 [0.19; 0.38]. Risk reduction was lower when adjusting for vaccination and prior diagnosed infection (aHR:0.41, 95% CI: 0.29; 0.59) and reduced further when accounting for unascertained prior infections (aHR: 0.72). Vaccine protection was maintained in wave four (aHR for outcome of death: 0.24; 95% CI: 0.10; 0.58). Conclusions: In the Omicron-driven wave, severe COVID-19 outcomes were reduced mostly due to protection conferred by prior infection and/or vaccination, but intrinsically reduced virulence may account for an approximately 25% reduced risk of severe hospitalization or death compared to Delta.

Published
2022

5. Consumer and Public Involvement in Guideline Development

Author

Robertson, P. and Hussey, H.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Background: In March 2011, the Institute of Medicine released a consensus report titled 'Clinical Practice Guidelines We Can Trust'. The report highlighted eight standards that epitomized trustworthy guidelines and included calls for greater consumer and public involvement in the guideline[for full text, please go to the a.m. URL], G-I-N Conference 2012

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results