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7. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.

Author

Holmes, Michael V, Dale, Caroline E, Zuccolo, Luisa, Silverwood, Richard J, Guo, Yiran, Ye, Zheng, Prieto-Merino, David, Dehghan, Abbas, Trompet, Stella, Wong, Andrew, Cavadino, Alana, Drogan, Dagmar, Padmanabhan, Sandosh, Li, Shanshan, Yesupriya, Ajay, Leusink, Maarten, Sundstrom, Johan, Hubacek, Jaroslav A, Pikhart, Hynek, Swerdlow, Daniel I, Panayiotou, Andrie G, Borinskaya, Svetlana A, Finan, Chris, Shah, Sonia, Kuchenbaecker, Karoline B, Shah, Tina, Engmann, Jorgen, Folkersen, Lasse, Eriksson, Per, Ricceri, Fulvio, Melander, Olle, Sacerdote, Carlotta, Gamble, Dale M, Rayaprolu, Sruti, Ross, Owen A, McLachlan, Stela, Vikhireva, Olga, Sluijs, Ivonne, Scott, Robert A, Adamkova, Vera, Flicker, Leon, Bockxmeer, Frank M van, Power, Christine, Marques-Vidal, Pedro, Meade, Tom, Marmot, Michael G, Ferro, Jose M, Paulos-Pinheiro, Sofia, Humphries, Steve E, Talmud, Philippa J, Mateo Leach, Irene, Verweij, Niek, Linneberg, Allan, Skaaby, Tea, Doevendans, Pieter A, Cramer, Maarten J, van der Harst, Pim, Klungel, Olaf H, Dowling, Nicole F, Dominiczak, Anna F, Kumari, Meena, Nicolaides, Andrew N, Weikert, Cornelia, Boeing, Heiner, Ebrahim, Shah, Gaunt, Tom R, Price, Jackie F, Lannfelt, Lars, Peasey, Anne, Kubinova, Ruzena, Pajak, Andrzej, Malyutina, Sofia, Voevoda, Mikhail I, Tamosiunas, Abdonas, Maitland-van der Zee, Anke H, Norman, Paul E, Hankey, Graeme J, Bergmann, Manuela M, Hofman, Albert, Franco, Oscar H, Cooper, Jackie, Palmen, Jutta, Spiering, Wilko, de Jong, Pim A, Kuh, Diana, Hardy, Rebecca, Uitterlinden, Andre G, Ikram, M Arfan, Ford, Ian, Hyppönen, Elina, Almeida, Osvaldo P, Wareham, Nicholas J, Khaw, Kay-Tee, Hamsten, Anders, Husemoen, Lise Lotte N, Tjønneland, Anne, Tolstrup, Janne S, Rimm, Eric, Beulens, Joline WJ, and Verschuren, WM Monique

Subjects
InterAct Consortium, Humans, Coronary Disease, Alcohol Dehydrogenase, Genetic Markers, Models, Statistical, Alcohol Drinking, Genotype, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Female, Male, Stroke, Mendelian Randomization Analysis, Biomarkers, General & Internal Medicine, Clinical Sciences, Public Health and Health Services
Abstract

ObjectiveTo use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.DesignMendelian randomisation meta-analysis of 56 epidemiological studies.Participants261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers.Main outcome measuresOdds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption.ResultsCarriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m(2)). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)).ConclusionsIndividuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.

Published
2014

8. Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease

Author

Medici, Marco, Porcu, Eleonora, Pistis, Giorgio, Teumer, Alexander, Brown, Suzanne J, Jensen, Richard A, Rawal, Rajesh, Roef, Greet L, Plantinga, Theo S, Vermeulen, Sita H, Lahti, Jari, Simmonds, Matthew J, Husemoen, Lise Lotte N, Freathy, Rachel M, Shields, Beverley M, Pietzner, Diana, Nagy, Rebecca, Broer, Linda, Chaker, Layal, Korevaar, Tim IM, Plia, Maria Grazia, Sala, Cinzia, Völker, Uwe, Richards, J Brent, Sweep, Fred C, Gieger, Christian, Corre, Tanguy, Kajantie, Eero, Thuesen, Betina, Taes, Youri E, Visser, W Edward, Hattersley, Andrew T, Kratzsch, Jürgen, Hamilton, Alexander, Li, Wei, Homuth, Georg, Lobina, Monia, Mariotti, Stefano, Soranzo, Nicole, Cocca, Massimiliano, Nauck, Matthias, Spielhagen, Christin, Ross, Alec, Arnold, Alice, van de Bunt, Martijn, Liyanarachchi, Sandya, Heier, Margit, Grabe, Hans Jörgen, Masciullo, Corrado, Galesloot, Tessel E, Lim, Ee M, Reischl, Eva, Leedman, Peter J, Lai, Sandra, Delitala, Alessandro, Bremner, Alexandra P, Philips, David IW, Beilby, John P, Mulas, Antonella, Vocale, Matteo, Abecasis, Goncalo, Forsen, Tom, James, Alan, Widen, Elisabeth, Hui, Jennie, Prokisch, Holger, Rietzschel, Ernst E, Palotie, Aarno, Feddema, Peter, Fletcher, Stephen J, Schramm, Katharina, Rotter, Jerome I, Kluttig, Alexander, Radke, Dörte, Traglia, Michela, Surdulescu, Gabriela L, He, Huiling, Franklyn, Jayne A, Tiller, Daniel, Vaidya, Bijay, de Meyer, Tim, Jørgensen, Torben, Eriksson, Johan G, O'Leary, Peter C, Wichmann, Eric, Hermus, Ad R, Psaty, Bruce M, Ittermann, Till, Hofman, Albert, Bosi, Emanuele, Schlessinger, David, Wallaschofski, Henri, Pirastu, Nicola, Aulchenko, Yurii S, de la Chapelle, Albert, Netea-Maier, Romana T, Gough, Stephen CL, Schwabedissen, Henriette Meyer zu, Frayling, Timothy M, and Kaufman, Jean-Marc

Subjects
Biological Sciences, Genetics, Prevention, Clinical Research, Autoimmune Disease, 2.1 Biological and endogenous factors, Aetiology, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Metabolic and endocrine, Autoantibodies, Genetic Loci, Genome-Wide Association Study, Graves Disease, Hashimoto Disease, Humans, Iodide Peroxidase, Risk Factors, Thyroiditis, Autoimmune, Thyrotropin, Developmental Biology
Abstract

Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely unknown, we performed GWAS meta-analyses in 18,297 individuals for TPOAb-positivity (1769 TPOAb-positives and 16,528 TPOAb-negatives) and in 12,353 individuals for TPOAb serum levels, with replication in 8,990 individuals. Significant associations (P

Published
2014

9. Fetal Overgrowth and Preterm Delivery in Women With Type 1 Diabetes Using Insulin Pumps or Multiple Daily Injections: A Post Hoc Analysis of the EVOLVE Study Cohort.

Author

Thorius, Ida Holte, Husemoen, Lise Lotte N., Nordsborg, Rikke Baastrup, Alibegovic, Amra C., Gall, Mari-Anne, Petersen, Janne, Damm, Peter, and Mathiesen, Elisabeth R.

Subjects
*PREMATURE labor, *TYPE 1 diabetes, *INSULIN pumps, *INSULIN therapy, *CONTINUOUS glucose monitoring
Abstract

OBJECTIVE: To compare the risk of fetal overgrowth and preterm delivery in pregnant women with type 1 diabetes (T1D) treated with insulin pumps versus multiple daily injections (MDI) and examine whether possible differences were mediated through improved glycemic control or gestational weight gain during pregnancy. RESEARCH DESIGN AND METHODS: The risk of pregnancy and perinatal outcomes were evaluated in a cohort of 2,003 pregnant women with T1D enrolled from 17 countries in a real-world setting during 2013–2018. RESULTS: In total, 723 women were treated with pumps and 1,280 with MDI. At inclusion (median gestational weeks 8.6 [interquartile range 7–10]), pump users had lower mean HbA1c (mean ± SD 50.6 ± 9.8 mmol/mol [6.8 ± 0.9%] vs. 53.6 ± 13.8 mmol/mol [7.1 ± 1.3%], P < 0.001), longer diabetes duration (18.4 ± 7.8 vs. 14.4 ± 8.2 years, P < 0.001), and higher prevalence of retinopathy (35.3% vs. 24.4%, P < 0.001). Proportions of large for gestational age (LGA) offspring and preterm delivery were 59.0% vs. 52.2% (adjusted odds ratio [OR] 1.36 [95% CI 1.09; 1.70], P = 0.007) and 39.6% vs. 32.1% (adjusted OR 1.46 (95% CI 1.17; 1.82), P < 0.001), respectively. The results did not change after adjustment for HbA1c or gestational weight gain. CONCLUSIONS: Insulin pump treatment in pregnant women with T1D, prior to the widespread use of continuous glucose monitoring or automated insulin delivery, was associated with a higher risk of LGA offspring and preterm delivery compared with MDI in crude and adjusted analyses. This association did not appear to be mediated by differences in glycemic control as represented by HbA1c or by gestational weight gain. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Prevalence of Diabetes and Cardiovascular Risk in the Middle East and Africa: Primary Results of the PACT-MEA Study

Author

Verma, Subodh, primary, Alamuddin, Naji, additional, Alawadi, Fatheya, additional, Alkandari, Hessa, additional, Almahmeed, Wael, additional, Assaad-Khalil, Samir H., additional, Haddad, Jihad, additional, Husemoen, Lise Lotte N., additional, Lombard, Landman, additional, Malik, Rayaz A., additional, Mashaki Ceyhan, Emel, additional, Sabbour, Hani, additional, Tombak, Gamze, additional, Yadav, Gourav, additional, and Salek, Sam, additional

Published
2023
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16. Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data

Author

IMPROVE study group, The InterAct Consortium, Holmes, Michael V, Dale, Caroline E, Zuccolo, Luisa, Silverwood, Richard J, Guo, Yiran, Ye, Zheng, Prieto-Merino, David, Dehghan, Abbas, Trompet, Stella, Wong, Andrew, Cavadino, Alana, Drogan, Dagmar, Padmanabhan, Sandosh, Li, Shanshan, Yesupriya, Ajay, Leusink, Maarten, Sundstrom, Johan, Hubacek, Jaroslav A, Pikhart, Hynek, Swerdlow, Daniel I, Panayiotou, Andrie G, Borinskaya, Svetlana A, Finan, Chris, Shah, Sonia, Kuchenbaecker, Karoline B, Shah, Tina, Engmann, Jorgen, Folkersen, Lasse, Eriksson, Per, Ricceri, Fulvio, Melander, Olle, Sacerdote, Carlotta, Gamble, Dale M, Rayaprolu, Sruti, Ross, Owen A, McLachlan, Stela, Vikhireva, Olga, Sluijs, Ivonne, Scott, Robert A, Adamkova, Vera, Flicker, Leon, van Bockxmeer, Frank M, Power, Christine, Marques-Vidal, Pedro, Meade, Tom, Marmot, Michael G, Ferro, Jose M, Paulos-Pinheiro, Sofia, Humphries, Steve E, Talmud, Philippa J, Leach, Irene Mateo, Verweij, Niek, Linneberg, Allan, Skaaby, Tea, Doevendans, Pieter A, Cramer, Maarten J, van der Harst, Pim, Klungel, Olaf H, Dowling, Nicole F, Dominiczak, Anna F, Kumari, Meena, Nicolaides, Andrew N, Weikert, Cornelia, Boeing, Heiner, Ebrahim, Shah, Gaunt, Tom R, Price, Jackie F, Lannfelt, Lars, Peasey, Anne, Kubinova, Ruzena, Pajak, Andrzej, Malyutina, Sofia, Voevoda, Mikhail I, Tamosiunas, Abdonas, Maitland-vanderZee, Anke H, Norman, Paul E, Hankey, Graeme J, Bergmann, Manuela M, Hofman, Albert, Franco, Oscar H, Cooper, Jackie, Palmen, Jutta, Spiering, Wilko, de Jong, Pim A, Kuh, Diana, Hardy, Rebecca, Uitterlinden, Andre G, Ikram, M Arfan, Ford, Ian, Hyppönen, Elina, Almeida, Osvaldo P, Wareham, Nicholas J, Khaw, Kay-Tee, Hamsten, Anders, Husemoen, Lise Lotte N, Tjønneland, Anne, Tolstrup, Janne S, Rimm, Eric, Beulens, Joline W J, Verschuren, W M Monique, Onland-Moret, N Charlotte, Hofker, Marten H, Wannamethee, S Goya, Whincup, Peter H, Morris, Richard, Vicente, Astrid M, Watkins, Hugh, Farrall, Martin, Jukema, J Wouter, Meschia, James, Cupples, L Adrienne, Sharp, Stephen J, Fornage, Myriam, Kooperberg, Charles, LaCroix, Andrea Z, Dai, James Y, Lanktree, Matthew B, Siscovick, David S, Jorgenson, Eric, Spring, Bonnie, Coresh, Josef, Li, Yun R, Buxbaum, Sarah G, Schreiner, Pamela J, Curtis, R, Y Tsai, Michael, Patel, Sanjay R, Redline, Susan, Johnson, Andrew D, Hoogeveen, Ron C, Hakonarson, Hakon, Rotter, Jerome I, Boerwinkle, Eric, de Bakker, Paul I W, Kivimaki, Mika, Asselbergs, Folkert W, Sattar, Naveed, Lawlor, Debbie A, Whittaker, John, Smith, George Davey, Mukamal, Kenneth, Psaty, Bruce M, Wilson, James G, Lange, Leslie A, Hamidovic, Ajna, Hingorani, Aroon D, Nordestgaard, Børge G, Bobak, Martin, Leon, David A, Langenberg, Claudia, Palmer, Tom M, Reiner, Alex P, Keating, Brendan J, Dudbridge, Frank, and Casas, Juan P

Published
2014

19. Characteristics of pregnant women with diabetes using injectable glucose lowering drugs in the EVOLVE study.

Author

Mathiesen, Elisabeth R., Ali, Norsiah, Anastasiou, Eleni, Cypryk, Katarzyna, de Valk, Harold W., Dores, Jorge M., Dunne, Fidelma P., Ekelund, Magnus, García, Santiago Durán, Hanaire, Hélène, Husemoen, Lise Lotte N., Ivanisevick, Marina, Kempe, Hans-Peter, Nordsborg, Rikke B., and McCance, David R.

Subjects
PREGNANT women, GLUCAGON-like peptide-1 receptor, TYPE 2 diabetes, DISEASE complications, PREGNANCY complications
Abstract

Aims To examine clinical parameters, glycemic control, folic acid supplementation, and the presence of other chronic diseases during early pregnancy in the EVOLVE study population (women with pre-existing diabetes treated with injectable glucose-lowering drugs). Methods Cross-sectional baseline evaluation of EVOLVE: an international, multicenter, non-interventional study investigating the safety of injectable glucose-lowering drugs in pregnant women with pre-existing type 1 (T1D) or type 2 diabetes (T2D). Data were collected at enrollment visit interviews before gestational week 16. Results In total, 2383 women from 17 mainly European countries were enrolled in the study: 2122 with T1D and 261 with T2D; mean age was 31 and 33 years, and duration of diabetes was 15 and 6 years, respectively. For women with T1D or T2D, 63% and 75%, respectively, received basal and rapid-acting insulin, 36% and 3% rapid-acting insulin only, 0.7% and 14.0% basal insulin only, 0.2% and 5.4% premix insulin, 0.0% and 1.2% injectable glucagon-like peptide-1 receptor agonist treatment without insulin. In women with T1D or T2D, respectively, during early pregnancy, 59% and 62% had HbA1c <7.0% (53 mmol/mol); 16% and 36% reported not taking folic acid before or during early pregnancy. Overall, >40% of women had ≥1 chronic concomitant condition (predominantly thyroid disease or hypertension). Retinopathy was the most commonly reported diabetic complication. The most commonly reported previous pregnancy complication was miscarriage. Conclusions Baseline data from this large multinational population of women with pre-existing diabetes indicate that sub-optimal glycemic control, poor pregnancy planning, and chronic concomitant conditions were common in early pregnancy. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Risk of Major Congenital Malformations or Perinatal or Neonatal Death With Insulin Detemir Versus Other Basal Insulins in Pregnant Women With Preexisting Diabetes: The Real-World EVOLVE Study

Author

Mathiesen, Elisabeth R., primary, Ali, Norsiah, additional, Alibegovic, Amra C., additional, Anastasiou, Eleni, additional, Cypryk, Katarzyna, additional, de Valk, Harold, additional, Dores, Jorge, additional, Dunne, Fidelma, additional, Gall, Mari-Anne, additional, Garcia, Santiago Duran, additional, Hanaire, Hélène P., additional, Husemoen, Lise Lotte N., additional, Ivanišević, Marina, additional, Kempe, Hans-Peter, additional, McCance, David R., additional, and Damm, Peter, additional

Published
2021
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21. Characteristics of pregnant women with diabetes using injectable glucose-lowering drugs in the EVOLVE study

Author

Mathiesen, Elisabeth R., primary, Ali, Norsiah, additional, Anastasiou, Eleni, additional, Cypryk, Katarzyna, additional, de Valk, Harold W., additional, Dores, Jorge M., additional, Dunne, Fidelma P., additional, Ekelund, Magnus, additional, Durán García, Santiago, additional, Hanaire, Hélène, additional, Husemoen, Lise Lotte N., additional, Ivanisevic, Marina, additional, Kempe, Hans-Peter, additional, Nordsborg, Rikke B., additional, and McCance, David R., additional

Published
2021
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23. Cardiovascular risk factors early in the course of treatment in people with type 2 diabetes without established cardiovascular disease: A population-based observational retrospective cohort study.

Author

Khunti, Kamlesh, Hertz, Christin L., Husemoen, Lise Lotte N., Mocevic, Emina, Nordsborg, Rikke B., Piltoft, Johanne S., and Bain, Stephen C.

Subjects
CARDIOVASCULAR diseases risk factors, SCIENTIFIC observation, CONFIDENCE intervals, CARDIOVASCULAR diseases, RETROSPECTIVE studies, TYPE 2 diabetes, COMPARATIVE studies, PROPORTIONAL hazards models
Abstract

Aims: To characterise the cardiovascular risk of people with type 2 diabetes without established cardiovascular disease but with risk factors, relative to those with established cardiovascular disease, to provide information on which patients could benefit from early use of glucose-lowering therapies that also reduce cardiovascular risk. Methods: Data from people with type 2 diabetes initiating second-line glucose-lowering medication were retrieved from the UK Clinical Practice Research Datalink GOLD database and linked with Hospital Episode Statistics and Office for National Statistics (2001-2016). Cox proportional hazards models were used to estimate relative risks of major adverse cardiovascular events within groups defined by the presence of selected risk factors in people without versus with established cardiovascular disease. Results: Of 53,182 individuals, 19.4% had established cardiovascular disease (i.e. a prior cardiovascular event). Over 5-7 years' follow-up, the rate of major adverse cardiovascular events was 14.0 and 49.6 events/1000 person-years without and with established cardiovascular disease, respectively (hazard ratio [HR] 0.28, 95% confidence interval [CI] 0.26, 0.29). Compared with a reference HR 1.0 for participants with established cardiovascular disease, estimated glomerular filtration rate <60 mL/min was the single factor associated with the highest risk of major adverse cardiovascular events (HR 0.75, 95% CI 0.70, 0.81) and mortality (HR 1.12, 95% CI 1.07, 1.18) in people with type 2 diabetes without established cardiovascular disease. The combination of chronic kidney disease with older age, smoking and/or dyslipidaemia was associated with a similarly high risk of cardiovascular events in people with type 2 diabetes and without cardiovascular disease compared with those having established cardiovascular disease. Conclusions: These analyses provide important information to identify people who may benefit from primary prevention of cardiovascular disease. Modifiable cardiovascular risk factors should be controlled early in all individuals with type 2 diabetes (as well as in all individuals with cardiovascular disease). [ABSTRACT FROM AUTHOR]

Published
2022
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30. Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight

Author

Rohde, Jeanett F, primary, Ängquist, Lars, additional, Larsen, Sofus C., additional, Tolstrup, Janne S., additional, Husemoen, Lise Lotte N., additional, Linneberg, Allan, additional, Toft, Ulla, additional, Overvad, Kim, additional, Halkjær, Jytte, additional, Tjønneland, Anne, additional, Hansen, Torben, additional, Pedersen, Oluf, additional, Sørensen, Thorkild I. A., additional, and Heitmann, Berit L, additional

Published
2017
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32. Heavier smoking may lead to a relative increase in waist circumference : evidence for causal relationship from a Mendelian iandomisation meta-analysis. The CARTA consortium

Author

Morris, Richard W., Taylor, Amy E., Fluharty, Meg E., Bjorngaard, Johan H., Asvold, Bjorn Olav, Gabrielsen, Maiken Elvestad, Campbell, Archie, Marioni, Riccardo, Kumari, Meena, Korhonen, Tellervo, Mannisto, Satu, Marques-Vidal, Pedro, Kaakinen, Marika, Cavadino, Alana, Postmus, Iris, Husemoen, Lise Lotte N., Skaaby, Tea, Ahluwalia, Tarun Veer Singh, Treur, Jorien L., Willemsen, Gonneke, Dale, Caroline, Wannamethee, S. Goya, Lahti, Jari, Palotie, Aarno, Räikkönen, Katri, McConnachie, Alex, Padmanabhan, Sandosh, Wong, Andrew, Dalgard, Christine, Paternoster, Lavinia, Ben-Shlomo, Yoav, Tyrrell, Jessica, Horwood, John, Fergusson, David M., Kennedy, Martin A., Nohr, Ellen A., Christiansen, Lene, Kyvik, Kirsten Ohm, Kuh, Diana, Watt, Graham, Eriksson, Johan G., Whincup, Peter H., Vink, Jacqueline M., Boomsma, Dorret I., Smith, George Davey, Lawlor, Debbie, Linneberg, Allan, Ford, Ian, Jukema, J. Wouter, Power, Chris, Hypponen, Elina, Jarvelin, Marjo-Riitta, Preisig, Martin, Borodulin, Katja, Kaprio, Jaakko, Kivimaki, Mika, Smith, Blair H., Hayward, Caroline, Romundstad, Pal R., Sorensen, Thorkild I. A., Munafo, Marcus R., Sattar, Naveed, Clinicum, Tellervo Korhonen / Principal Investigator, Department of Public Health, Behavioural Sciences, Institute for Molecular Medicine Finland, Aarno Palotie / Principal Investigator, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, Jaakko Kaprio / Principal Investigator, Developmental Psychology Research Group, Genomics of Neurological and Neuropsychiatric Disorders, and Genetic Epidemiology

Subjects
BODY-MASS INDEX, MORTALITY, RISK-FACTORS, WOMEN, CORONARY-HEART-DISEASE, ADIPOSITY, MEN, CIGARETTE-SMOKING, ASSOCIATION, WEIGHT CONCERNS, 3142 Public health care science, environmental and occupational health
Abstract

Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes. Participants: 148 731 current, former and neversmokers of European ancestry aged >= 16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Waist and hip circumferences, and waist-hip ratio. Results: The data included up to 66 809 never-smokers, 43 009 former smokers and 38 913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% Cl -0.57% to - 0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% Cl - 0.42% to -0.19), -0.08% (-0.19% to 0.03%) and - 0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele. Conclusions: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.

Published
2015

34. Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference

Author

Olsen, Nanna J, primary, Ängquist, Lars, additional, Larsen, Sofus C, additional, Linneberg, Allan, additional, Skaaby, Tea, additional, Husemoen, Lise Lotte N, additional, Toft, Ulla, additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Hansen, Torben, additional, Pedersen, Oluf, additional, Overvad, Kim, additional, Ahluwalia, Tarunveer S, additional, Sørensen, Thorkild IA, additional, and Heitmann, Berit L, additional

Published
2016
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35. Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity

Author

Larsen, Sofus C., primary, Ängquist, Lars, additional, Moldovan, Max, additional, Huikari, Ville, additional, Sebert, Sylvain, additional, Cavadino, Alana, additional, Singh Ahluwalia, Tarunveer, additional, Skaaby, Tea, additional, Linneberg, Allan, additional, Husemoen, Lise Lotte N., additional, Toft, Ulla, additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Herzig, Karl-Heinz, additional, Jarvelin, Marjo-Riitta, additional, Power, Chris, additional, Hyppönen, Elina, additional, Heitmann, Berit L., additional, and Sørensen, Thorkild I. A., additional

Published
2016
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37. Effect of Smoking on Blood Pressure and Resting Heart Rate

Author

Linneberg, Allan, primary, Jacobsen, Rikke K., additional, Skaaby, Tea, additional, Taylor, Amy E., additional, Fluharty, Meg E., additional, Jeppesen, Jørgen L., additional, Bjorngaard, Johan H., additional, Åsvold, Bjørn O., additional, Gabrielsen, Maiken E., additional, Campbell, Archie, additional, Marioni, Riccardo E., additional, Kumari, Meena, additional, Marques-Vidal, Pedro, additional, Kaakinen, Marika, additional, Cavadino, Alana, additional, Postmus, Iris, additional, Ahluwalia, Tarunveer S., additional, Wannamethee, S. Goya, additional, Lahti, Jari, additional, Räikkönen, Katri, additional, Palotie, Aarno, additional, Wong, Andrew, additional, Dalgård, Christine, additional, Ford, Ian, additional, Ben-Shlomo, Yoav, additional, Christiansen, Lene, additional, Kyvik, Kirsten O., additional, Kuh, Diana, additional, Eriksson, Johan G., additional, Whincup, Peter H., additional, Mbarek, Hamdi, additional, de Geus, Eco J.C., additional, Vink, Jacqueline M., additional, Boomsma, Dorret I., additional, Smith, George Davey, additional, Lawlor, Debbie A., additional, Kisialiou, Aliaksei, additional, McConnachie, Alex, additional, Padmanabhan, Sandosh, additional, Jukema, J. Wouter, additional, Power, Chris, additional, Hyppönen, Elina, additional, Preisig, Martin, additional, Waeber, Gerard, additional, Vollenweider, Peter, additional, Korhonen, Tellervo, additional, Laatikainen, Tiina, additional, Salomaa, Veikko, additional, Kaprio, Jaakko, additional, Kivimaki, Mika, additional, Smith, Blair H., additional, Hayward, Caroline, additional, Sørensen, Thorkild I.A., additional, Thuesen, Betina H., additional, Sattar, Naveed, additional, Morris, Richard W., additional, Romundstad, Pål R., additional, Munafò, Marcus R., additional, Jarvelin, Marjo-Riitta, additional, and Husemoen, Lise Lotte N., additional

Published
2015
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38. Standardizing serum 25-hydroxyvitamin D data from four Nordic population samples using theVitamin D Standardization Programprotocols: Shedding new light on vitamin D status in Nordic individuals

Author

Cashman, Kevin D., primary, Dowling, Kirsten G., additional, Škrabáková, Zuzana, additional, Kiely, Mairead, additional, Lamberg-Allardt, Christel, additional, Durazo-Arvizu, Ramon A., additional, Sempos, Christopher T., additional, Koskinen, Seppo, additional, Lundqvist, Annamari, additional, Sundvall, Jouko, additional, Linneberg, Allan, additional, Thuesen, Betina, additional, Husemoen, Lise Lotte N., additional, Meyer, Haakon E., additional, Holvik, Kristin, additional, Grønborg, Ida M., additional, Tetens, Inge, additional, and Andersen, Rikke, additional

Published
2015
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39. Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium: Table 1

Author

Morris, Richard W, primary, Taylor, Amy E, additional, Fluharty, Meg E, additional, Bjørngaard, Johan H, additional, Åsvold, Bjørn Olav, additional, Elvestad Gabrielsen, Maiken, additional, Campbell, Archie, additional, Marioni, Riccardo, additional, Kumari, Meena, additional, Korhonen, Tellervo, additional, Männistö, Satu, additional, Marques-Vidal, Pedro, additional, Kaakinen, Marika, additional, Cavadino, Alana, additional, Postmus, Iris, additional, Husemoen, Lise Lotte N, additional, Skaaby, Tea, additional, Ahluwalia, Tarun Veer Singh, additional, Treur, Jorien L, additional, Willemsen, Gonneke, additional, Dale, Caroline, additional, Wannamethee, S Goya, additional, Lahti, Jari, additional, Palotie, Aarno, additional, Räikkönen, Katri, additional, McConnachie, Alex, additional, Padmanabhan, Sandosh, additional, Wong, Andrew, additional, Dalgård, Christine, additional, Paternoster, Lavinia, additional, Ben-Shlomo, Yoav, additional, Tyrrell, Jessica, additional, Horwood, John, additional, Fergusson, David M, additional, Kennedy, Martin A, additional, Nohr, Ellen A, additional, Christiansen, Lene, additional, Kyvik, Kirsten Ohm, additional, Kuh, Diana, additional, Watt, Graham, additional, Eriksson, Johan G, additional, Whincup, Peter H, additional, Vink, Jacqueline M, additional, Boomsma, Dorret I, additional, Davey Smith, George, additional, Lawlor, Debbie, additional, Linneberg, Allan, additional, Ford, Ian, additional, Jukema, J Wouter, additional, Power, Chris, additional, Hyppönen, Elina, additional, Jarvelin, Marjo-Riitta, additional, Preisig, Martin, additional, Borodulin, Katja, additional, Kaprio, Jaakko, additional, Kivimaki, Mika, additional, Smith, Blair H, additional, Hayward, Caroline, additional, Romundstad, Pål R, additional, Sørensen, Thorkild I A, additional, Munafò, Marcus R, additional, and Sattar, Naveed, additional

Published
2015
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40. The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample

Author

Esserlind, Ann-Louise, primary, Christensen, Anne Francke, additional, Steinberg, Stacy, additional, Grarup, Niels, additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Werge, Thomas, additional, Hansen, Thomas Folkmann, additional, Husemoen, Lise Lotte N, additional, Linneberg, Allan, additional, Budtz-Jorgensen, Esben, additional, Westergaard, Maria Lurenda, additional, Stefansson, Hreinn, additional, and Olesen, Jes, additional

Published
2015
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41. Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers

Author

Taylor, Amy E., primary, Morris, Richard W., additional, Fluharty, Meg E., additional, Bjorngaard, Johan H., additional, Åsvold, Bjørn Olav, additional, Gabrielsen, Maiken E., additional, Campbell, Archie, additional, Marioni, Riccardo, additional, Kumari, Meena, additional, Hällfors, Jenni, additional, Männistö, Satu, additional, Marques-Vidal, Pedro, additional, Kaakinen, Marika, additional, Cavadino, Alana, additional, Postmus, Iris, additional, Husemoen, Lise Lotte N., additional, Skaaby, Tea, additional, Ahluwalia, Tarunveer S., additional, Treur, Jorien L., additional, Willemsen, Gonneke, additional, Dale, Caroline, additional, Wannamethee, S. Goya, additional, Lahti, Jari, additional, Palotie, Aarno, additional, Räikkönen, Katri, additional, Kisialiou, Aliaksei, additional, McConnachie, Alex, additional, Padmanabhan, Sandosh, additional, Wong, Andrew, additional, Dalgård, Christine, additional, Paternoster, Lavinia, additional, Ben-Shlomo, Yoav, additional, Tyrrell, Jessica, additional, Horwood, John, additional, Fergusson, David M., additional, Kennedy, Martin A., additional, Frayling, Tim, additional, Nohr, Ellen A., additional, Christiansen, Lene, additional, Ohm Kyvik, Kirsten, additional, Kuh, Diana, additional, Watt, Graham, additional, Eriksson, Johan, additional, Whincup, Peter H., additional, Vink, Jacqueline M., additional, Boomsma, Dorret I., additional, Davey Smith, George, additional, Lawlor, Debbie, additional, Linneberg, Allan, additional, Ford, Ian, additional, Jukema, J. Wouter, additional, Power, Christine, additional, Hyppönen, Elina, additional, Jarvelin, Marjo-Riitta, additional, Preisig, Martin, additional, Borodulin, Katja, additional, Kaprio, Jaakko, additional, Kivimaki, Mika, additional, Smith, Blair H., additional, Hayward, Caroline, additional, Romundstad, Pål R., additional, Sørensen, Thorkild I. A., additional, Munafò, Marcus R., additional, and Sattar, Naveed, additional

Published
2014
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42. Interaction between Genetic Predisposition to Adiposity and Dietary Protein in Relation to Subsequent Change in Body Weight and Waist Circumference

Author

Ankarfeldt, Mikkel Z., primary, Larsen, Sofus C., additional, Ängquist, Lars, additional, Husemoen, Lise Lotte N., additional, Roswall, Nina, additional, Overvad, Kim, additional, Jakobsen, Marianne Uhre, additional, Halkjær, Jytte, additional, Tjønneland, Anne, additional, Linneberg, Allan, additional, Toft, Ulla, additional, Hansen, Torben, additional, Pedersen, Oluf, additional, Heitmann, Berit L., additional, Astrup, Arne, additional, and Sørensen, Thorkild I. A., additional

Published
2014
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43. Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium

Author

Taylor, Amy E, primary, Fluharty, Meg E, additional, Bjørngaard, Johan H, additional, Gabrielsen, Maiken Elvestad, additional, Skorpen, Frank, additional, Marioni, Riccardo E, additional, Campbell, Archie, additional, Engmann, Jorgen, additional, Mirza, Saira Saeed, additional, Loukola, Anu, additional, Laatikainen, Tiina, additional, Partonen, Timo, additional, Kaakinen, Marika, additional, Ducci, Francesca, additional, Cavadino, Alana, additional, Husemoen, Lise Lotte N, additional, Ahluwalia, Tarunveer Singh, additional, Jacobsen, Rikke Kart, additional, Skaaby, Tea, additional, Ebstrup, Jeanette Frost, additional, Mortensen, Erik Lykke, additional, Minica, Camelia C, additional, Vink, Jacqueline M, additional, Willemsen, Gonneke, additional, Marques-Vidal, Pedro, additional, Dale, Caroline E, additional, Amuzu, Antoinette, additional, Lennon, Lucy T, additional, Lahti, Jari, additional, Palotie, Aarno, additional, Räikkönen, Katri, additional, Wong, Andrew, additional, Paternoster, Lavinia, additional, Wong, Angelita Pui-Yee, additional, Horwood, L John, additional, Murphy, Michael, additional, Johnstone, Elaine C, additional, Kennedy, Martin A, additional, Pausova, Zdenka, additional, Paus, Tomáš, additional, Ben-Shlomo, Yoav, additional, Nohr, Ellen A, additional, Kuh, Diana, additional, Kivimaki, Mika, additional, Eriksson, Johan G, additional, Morris, Richard W, additional, Casas, Juan P, additional, Preisig, Martin, additional, Boomsma, Dorret I, additional, Linneberg, Allan, additional, Power, Chris, additional, Hyppönen, Elina, additional, Veijola, Juha, additional, Jarvelin, Marjo-Riitta, additional, Korhonen, Tellervo, additional, Tiemeier, Henning, additional, Kumari, Meena, additional, Porteous, David J, additional, Hayward, Caroline, additional, Romundstad, Pål R, additional, Smith, George Davey, additional, and Munafò, Marcus R, additional

Published
2014
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45. Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts

Author

Larsen, Sofus C, primary, Ängquist, Lars, additional, Ahluwalia, Tarunveer Singh, additional, Skaaby, Tea, additional, Roswall, Nina, additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Overvad, Kim, additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Linneberg, Allan, additional, Husemoen, Lise Lotte N, additional, Toft, Ulla, additional, Heitmann, Berit L, additional, and Sørensen, Thorkild IA, additional

Published
2014
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48. Association between Loss-of-Function Mutations in the Filaggrin Gene and Self-Reported Food Allergy and Alcohol Sensitivity

Author

Linneberg, Allan, primary, Fenger, Runa V., additional, Husemoen, Lise-Lotte N., additional, Thuesen, Betina H., additional, Skaaby, Tea, additional, Gonzalez-Quintela, Arturo, additional, Vidal, Carmen, additional, Carlsen, Berit C., additional, Johansen, Jeanne D., additional, Menné, Torkil, additional, Stender, Steen, additional, Melgaard, Michael, additional, Szecsi, Pal B., additional, Berg, Nikolaj D., additional, and Thyssen, Jacob P., additional

Published
2013
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49. Standardizing serum 25-hydroxyvitamin D data from four Nordic population samples using the Vitamin D Standardization Program protocols: Shedding new light on vitamin D status in Nordic individuals.

Author

Cashman, Kevin D, Dowling, Kirsten G, Skrabáková, Zuzana, Kiely, Mairead, Lamberg-Allardt, Christel, Durazo-Arvizu, Ramon A, Sempos, Christopher T, Koskinen, Seppo, Lundqvist, Annamari, Sundvall, Jouko, Linneberg, Allan, Thuesen, Betina, Husemoen, Lise Lotte N, Meyer, Haakon E, Holvik, Kristin, Grønborg, Ida M, Tetens, Inge, and Andersen, Rikke

Published
2015
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