31 results on '"Huschek, D"'
Search Results
2. OP0219 INCIDENCE OF MAJOR ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH JAK-INHIBITORS COMPARED TO BDMARDS: DATA FROM AN INTERNATIONAL COLLABORATION OF REGISTRIES (THE “JAK-POT” STUDY)
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Aymon, R., primary, Mongin, D., additional, Bergstra, S. A., additional, Choquette, D., additional, Codreanu, C., additional, Cordtz, R. L., additional, Diederik, D. C., additional, Dreyer, L., additional, Elkayam, O., additional, Huschek, D., additional, Hyrich, K., additional, Iannone, F., additional, Inanc, N., additional, Kearsley-Fleet, L., additional, Kvien, T. K., additional, Leeb, B., additional, Lukina, G., additional, Nordström, D., additional, Onen, F., additional, Pavelka, K., additional, Pombo-Suarez, M., additional, Aarrestad Provan, S., additional, Rodrigues, A. M., additional, Rotar, Z., additional, Strangfeld, A., additional, Verschueren, P., additional, Zavada, J., additional, Courvoisier, D., additional, Finckh, A., additional, and Lauper, K., additional
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- 2023
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3. Beginn der Behandlung mit einem Januskinase-Inhibitor vor und nach den Sicherheitswarnungen: Veränderungen bei den Merkmalen von Patienten mit rheumatoider Arthritis
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Huschek, D, Herzer, P, Zink, A, Feuchtenberger, M, Strangfeld, A, Huschek, D, Herzer, P, Zink, A, Feuchtenberger, M, and Strangfeld, A
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- 2023
4. POS0234 HOW CLOSELY DO GERMAN RHEUMATOLOGISTS FOLLOW THE EULAR RECOMMENDATIONS FOR THE MANAGEMENT OF RHEUMATOID ARTHRITIS WHEN MAKING THERAPEUTIC DECISIONS?
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Meissner, Y., primary, Huschek, D., additional, Zink, A., additional, Kaufmann, J., additional, Bohl-Buehler, M., additional, and Strangfeld, A., additional
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- 2022
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5. Erfolgt die Therapieeskalation bei Patienten mit rheumatoider Arthritis gemäß der deutschen S2e-Leitlinie? - Daten aus dem Biologika Register RABBIT
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Meissner, Y, Huschek, D, Zink, A, Kaufmann, J, Bohl-Bühler, M, Strangfeld, A, Meissner, Y, Huschek, D, Zink, A, Kaufmann, J, Bohl-Bühler, M, and Strangfeld, A
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- 2022
6. INCIDENCE OF MAJOR ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH JAK-INHIBITORS COMPARED TO BDMARDS: DATA FROM AN INTERNATIONAL COLLABORATION OF REGISTRIES (THE "JAK-POT" STUDY).
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Aymon, R., Mongin, D., Bergstra, S. A., Choquette, D., Codreanu, C., Cordtz, R. L., Diederik, D. C., Dreyer, L., Elkayam, O., Huschek, D., Hyrich, K., Iannone, F., Inanc, N., Kearsley-Fleet, L., Kvien, T. K., Leeb, B., Lukina, G., Nordström, D., Onen, F., and Pavelka, K.
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- 2023
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7. OP0105 FEASIBILITY AND USEFULNESS OF MAPPING BIOLOGIC REGISTRIES TO A COMMON DATA MODEL: ILLUSTRATION USING COMORBIDITIES
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Kearsley-Fleet, L., primary, Hyrich, K., additional, Schaefer, M., additional, Huschek, D., additional, Strangfeld, A., additional, Zavada, J., additional, Lagová, M., additional, Courvoisier, D., additional, Tellenbach, C., additional, Lauper, K., additional, Sánchez-Piedra, C., additional, Montero, N., additional, Sánchez-Costa, J. T., additional, Prieto-Alhambra, D., additional, and Burn, E., additional
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- 2021
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8. OP0285 TOWARDS IMPLEMENTING THE OMOP CDM ACROSS FIVE EUROPEAN BIOLOGIC REGISTRIES
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Burn, E., primary, Kearsley-Fleet, L., additional, Hyrich, K., additional, Schaefer, M., additional, Huschek, D., additional, Strangfeld, A., additional, Zavada, J., additional, Lagová, M., additional, Courvoisier, D., additional, Tellenbach, C., additional, Lauper, K., additional, Sánchez-Piedra, C., additional, Montero, N., additional, Sanchez-Costa, J. T., additional, and Prieto-Alhambra, D., additional
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- 2020
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9. INITIATION OF A JANUS KINASE INHIBITOR BEFORE AND AFTER THE SAFETY WARNINGS: CHANGES IN CHARACTERISTICS OF PATIENTS WITH RHEUMATOID ARTHRITIS.
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Huschek, D., Herzer, P., Zink, A., Feuchtenberger, M., and Strangfeld, A.
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- 2023
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10. The European second generation compared: does the integration context matter?
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Hamel, C., Huschek, D., Milewsky, N. & de Valk, H.A.G. / In M. Crul, J. Schneider & F. Lelie (Eds.), Hamel, C, Huschek, D, and Milewsky, N. & de Valk, H.A.G. / In M. Crul, J. Schneider & F. Lelie (Eds.)
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- 2012
11. Special issue on Criminal Careers and Demographic Outcomes: A life-course perspective
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Bijleveld, C., Zoutewelle-Terovan, M., Huschek, D., Liefbroer, A.C., Bijleveld, C., Zoutewelle-Terovan, M., Huschek, D., and Liefbroer, A.C.
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- 2016
12. Criminal careers and demographic outcomes: An introduction to the special issue
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Bijleveld, C., Zoutewelle-Terovan, M., Huschek, D., Liefbroer, A.C., Bijleveld, C., Zoutewelle-Terovan, M., Huschek, D., and Liefbroer, A.C.
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- 2016
13. Parental criminality and entry into parenthood among sons and daughters
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Bijleveld, C., Huschek, D., Liefbroer, A.C., Bijleveld, C., Huschek, D., and Liefbroer, A.C.
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n this article, we examined to what extent parental offending influences the timing of entry into parenthood of children. Based on a literature review, we hypothesized that children of delinquent parents would be more likely to enter into parenthood at a relatively young age, and that part of that association could be explained by differences between children of delinquent and non-delinquent parents in the timing of entry into marriage and in their own delinquent behaviour. Using data from a five-generation study of high risk families in the Netherlands, we found that parental delinquency increases the chance of early childbearing among daughters, but not among sons. Among sons, parental delinquency increased son's delinquency, suggesting that parental delinquency has different consequences for the life courses of their sons and daughters.
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- 2016
14. Parental imprisonment and offspring outcomes: a study on offending and marriage chances
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Bijleveld, C.C.J.H., van de Weijer, S.G.A., Besemer, S., Huschek, D., Murray, J., Bijleveld, C.C.J.H., and Farrington, D.P.
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- 2014
15. Offending and mortality
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Bijleveld, C., Huschek, D., van de Weijer, S., van Poppel, F.W.A., and Nederlands Interdisciplinair Demografisch Instituut (NIDI)
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- 2012
16. Union formation and partner choice
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Hamel, C., Huschek, D., Milewsky, N., de Valk, H.A.G., Crul, M., Schneider, J., Lelie, F., and Nederlands Interdisciplinair Demografisch Instituut (NIDI)
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- 2012
17. Does social embeddedness influence union formation differences among the Turkish and Moroccan generation in the Netherlands?
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Huschek, D and de Valk, H.A.G. & Liefbroer, A.C.
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- 2011
18. Union formation and partner choice of the second generation of Turkish origin in Europe: The influence of third parties and institutional context
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Huschek, D., Liefbroer, AC, de Valk, H.A.G., Sociology, and Social Inequality and the Life Course (SILC)
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- 2011
19. Does social embeddedness influence union formation differences among the Turkish and Moroccan generation in the Netherlands?
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Huschek, D., de Valk, H.A.G., Liefbroer, A.C., and Netherlands Interdisciplinary Demographic Institute (NIDI)
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So far, most studies have examined the role of peers in school achievement, language acquisition and ethnic identity of second-generation migrants.This paper contributes to the literature first of all by studying how non-family networks influence union formation decisions of the second generation. Secondly, making a distinction between types of contact adds a new perspective to the study of network influence on union formation whereby strong ties consist of close friends and weak ties of acquaintances. Thirdly, comparing the relative importance of non-co-ethnic networks among men and women of two ethnic groups that share broad cultural and social similarities reveals the importance of these networks for different origin groups. Finally, studying multiple aspects of union formation enables a better assessment of the importance of social embeddedness into non-co-ethnic networks for choices in the family domain. In this paper, four aspects of union formation are covered, namely the timing of first union, timing of the first marriage, the type of union that is chosen and the ethnic origin of the partner.
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- 2011
20. A study of gender role attitudes and behavior among second-generation Turks with a first generation, second generation and native partner
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Huschek, D., De Valk, Helga, Liefbroer, Aart C., Social Research, and Interface Demography
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Europe ,second generation ,gender roles ,partner choice - Abstract
The partner choice of migrants and their children receives traditionally a lot of attention. Very often it is assumed that those with overall more traditional attitudes would be more likely to be married to a first-generation co-ethnic partner. Whether these attitudinal differences also translate into different behavior within couples living together remains unanswered. Linking the partner type and the division of tasks in the household can provide more in-depth insights in these different partnership arrangements. In addition, we compare the gender role behavior of second-generation Turks and natives in different European countries. It has been shown that gender role behavior overall differs throughout Europe. How and to what extend the societal context and policies would affect the gender role behavior of second-generation Turks in the same way has not been studied before. Using TIES data (2007-08), we aim at comparing gender role behavior of the Turkish second generation (with a first generation, a second generation, and a native partner) and native young adults across Europe. We include different aspects of gender role behavior (labor force participation, sharing of household tasks, childcare and taking care of finances). The study will take into account individual, family and partner characteristics. First results indicate that among the majority native population couples more often share tasks whereas this is less the case for the Turkish. Being higher educated results in more sharing of tasks for young adults of all origins. Finally, Turkish second-generation women living with a first-generation partner are more involved in taking care of finances than is the case for those with a second-generation partner. This suggests that gender role behavior and division of tasks is not only the result of attitudes but may also be influenced by practical constraints.
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- 2010
21. Partner Choice between Preferences and Structural Constraints: The Case of the Turkish Second Generation in Europe
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Huschek, D., De Valk, Helga, Liefbroer, Aart C., Social Research, and Interface Demography
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Europe ,second generation ,partner choice ,intermarriage ,Turkish migrants - Abstract
Among migrants & their descendants, it may not be sufficient to simply contrast exogamous & endogamous unions to draw conclusions on social distance or integration trends. A second-generation partner may constitute an important alternative, e.g. may represent an in-between choice between a first-generation & a native partner in terms of orientation toward the country of origin or the host country. Using TIES data (2007-08), this paper aims to contribute to the study of intermarriage by giving a comparative picture of the partner choice among second-generation Turks in 13 European cities in 7 countries. Specific attention is paid to the role of pref-erences, parents & non-coethnic peers as well as context factors such as group size & the type of integration policies. Competing risk models suggest that second-generation Turks with a propensity for a secondgeneration partner may be located on a continuum between the ‘poles’ of the other two partner choices in terms of family values & orientation toward the host country. The findings suggest furthermore that a shortage of suitable second-generation partners does not increase intermarriage rates, but rather leads to an increased pressure to find a suitable firstgeneration partner.
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- 2010
22. Union formation of the Turkish second generation
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Huschek, D., Hamel, Christelle, De Valk, Helga, Milewski, Nadja, Social Research, and Interface Demography
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Europe ,union formation ,second generation ,partner choice - Abstract
Partner choice and union formation as well as the family formation are the results of various social determinants: many sociological and demographic studies have shown that social homogamy plays an important role in the partner choice and that the timing of the union formation as well as the first birth is highly determined by the level of education. Some changes during the last decades have been identified too: the age at first union and at first birth is considerably delayed and there is a strong decline of marriage. These changes are due to both the increase of the age at the completion of education and the transformation of norms and values regarding sexuality and matrimonial life. These general trends vary by country but they are quite well studied in Europe. Nevertheless, we know quite few things on the matrimonial practice of descendants of immigrants. Descendants of immigrants have to manage the differences between their parents' culture of origin and the culture of the society in which they have been raised. This is particularly true for descendant of immigrants coming from Muslim countries such as Turkey where the patterns of union formation are clearly different from those in Europe: indeed, marriage is universal and age at marriage remains low. Yet, little is known about the matrimonial behaviors of the women and men of immigrant parentage in Western Europe. This chapter aims at expanding this knowledge by focusing on the transition to a first union of young adults of Turkish descent living in Europe. We especially study the timing of the first union, the type of union (marriage or cohabitation), the partner's origin and the partner's characteristics and especially the trend to form a transnational union. Variations between countries and between cities are discussed from the history of the Turkish migration and the size of the Turkish matrimonial market in each country. to which descendants of Turkish immigrants form a specific group (or not) among young adults, and to what extent they combine the patterns of their parents' country of origin and of their country of residence. In addition, diversity within the groups will be studied in the different national and city-level contexts.
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- 2010
23. Partner choice among the second generation: the influence of peers, parents and context
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Huschek, D., De Valk, Helga, Liefbroer, Aart C., Social Research, and Interface Demography
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children of immigrants ,Europe ,second generation ,Turks ,partner choice ,peers - Abstract
This study examines partner choice among the Turkish second generation by using data from a European wide survey (TIES). First, we aim to increase our insights into the intermarriage rates of the Turkish second generation. Second, our work goes beyond previous research by studying the influence of both parents and peers as well the effect that the host country context may exert on partner choice. Third, we not only study intermarriage with a native born partner, but include unions with a second generation partner from the same origin. Multinominal regression analyses show that marriage regimes and peer effects differentiate second-generation youths with a second generation partner from those with a first generation partner. For the choice between a native partner and a first-generation partner both parents and peers seem relevant. Further, both unions with second generation and native partners were less likely in countries with predominantly multicultural policies.
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- 2010
24. Does social embedness influence union formation differences among the Turkish and Moroccan second generation in the Netherlands?
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De Valk, Helga, Huschek, D., Liefbroer, Aart C., and Interface Demography
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Embedness - Published
- 2008
25. Partner choice patterns among the descendants of Turkish immigrants in Europe
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Huschek, D., de Valk, H.A.G., Liefbroer, A.C., Huschek, D., de Valk, H.A.G., and Liefbroer, A.C.
- Abstract
We examine the partner choice patterns of second-generation Turks in 13 European cities in seven countries. We not only compare intermarriage versus endogamous marriage, but also explicitly include the choice of a second-generation partner of the same origin and of a partner of other migrant origin as important alternatives. In Europe, populations are made up increasingly of migrants and their descendants resulting in new alternative partner options not open before. Findings suggest that second-generation Turks who choose a second-generation partner seem to be located between the partner choice of a first-generation and native partner in terms of family values and contact to non-coethnic peers. The choice of a partner of other migrant origin hardly differs in these characteristics from the choice of a native partner. Context variables such as group size and type of integration policies seem to play a role for the likelihood of having a first-generation versus a secondgeneration partner of Turkish origin but not for the likelihood of exogamous partner choice. A second-generation partner is the most popular choice in Germany but represents a minor option in the other countries. Furthermore, a partner of other migrant origin is more common among men but is in some countries more popular than a native partner among Turkish second-generation men and women. Keywords: second generation migrants; intermarriage; Europe; Turks; partner choice, We examine the partner choice patterns of second-generation Turks in 13 European cities in seven countries. We not only compare intermarriage versus endogamous marriage, but also explicitly include the choice of a second-generation partner of the same origin and of a partner of other migrant origin as important alternatives. In Europe, populations are made up increasingly of migrants and their descendants resulting in new alternative partner options not open before. Findings suggest that second-generation Turks who choose a second-generation partner seem to be located between the partner choice of a first-generation and native partner in terms of family values and contact to non-coethnic peers. The choice of a partner of other migrant origin hardly differs in these characteristics from the choice of a native partner. Context variables such as group size and type of integration policies seem to play a role for the likelihood of having a first-generation versus a secondgeneration partner of Turkish origin but not for the likelihood of exogamous partner choice. A second-generation partner is the most popular choice in Germany but represents a minor option in the other countries. Furthermore, a partner of other migrant origin is more common among men but is in some countries more popular than a native partner among Turkish second-generation men and women. Keywords: second generation migrants; intermarriage; Europe; Turks; partner choice
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- 2012
26. Gender-role behavior of second-generation Turks: the role of partner choice, gender ideology and societal context
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Huschek, D., de Valk, H.A.G., Liefbroer, A.C., Huschek, D., de Valk, H.A.G., and Liefbroer, A.C.
- Abstract
This study explores and compares gender-role behavior of second-generation Turks in six European countries. On the individual level, we study the role of gender ideology and consequences of (transnational) partner choice on four aspects of gender-role behavior; childcare, routine household tasks, financial matters, and income contribution. Furthermore, we ask whether welfare state regimes and policies have a similar effect on the gender-role behavior of the second generation across countries, as they have on the majority populations. Analyzing data from the survey The Integration of the European Second Generation (TIES, 2006-08), we find that the gender-role behavior of secondgeneration Turks follows a typology based on gender relations and predominant family models, but mainly for the traditionally female domain of childcare and routine household tasks. Our results show that contributing to the household income is clearly shared in Sweden, but less so in the other countries. Taking care of financial matters follows no clear country pattern and women are twice as likely as men to indicate this as a shared task. The findings underline the importance of policies in shaping gender-role behavior also for migrants and their descendants. Intra-group comparison points to the strong influence of gender ideology on behavior and to the fact that men choosing a partner from Turkey live in couples where the division of labor is the most traditional. Keywords: Gender-role behavior; second generation; Turks; partner choice, This study explores and compares gender-role behavior of second-generation Turks in six European countries. On the individual level, we study the role of gender ideology and consequences of (transnational) partner choice on four aspects of gender-role behavior; childcare, routine household tasks, financial matters, and income contribution. Furthermore, we ask whether welfare state regimes and policies have a similar effect on the gender-role behavior of the second generation across countries, as they have on the majority populations. Analyzing data from the survey The Integration of the European Second Generation (TIES, 2006-08), we find that the gender-role behavior of secondgeneration Turks follows a typology based on gender relations and predominant family models, but mainly for the traditionally female domain of childcare and routine household tasks. Our results show that contributing to the household income is clearly shared in Sweden, but less so in the other countries. Taking care of financial matters follows no clear country pattern and women are twice as likely as men to indicate this as a shared task. The findings underline the importance of policies in shaping gender-role behavior also for migrants and their descendants. Intra-group comparison points to the strong influence of gender ideology on behavior and to the fact that men choosing a partner from Turkey live in couples where the division of labor is the most traditional. Keywords: Gender-role behavior; second generation; Turks; partner choice
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- 2011
27. Timing of first union among second-generation Turks in Europe: The role of parents, peers and institutional context
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Huschek, D., Liefbroer, A.C., de Valk, H.A.G., Huschek, D., Liefbroer, A.C., and de Valk, H.A.G.
- Abstract
This study examines the influence of parents and peers on first union timing among the Turkish second generation in Europe using pooled data from the TIES survey. Cross-national differences in union formation are assessed by comparing countries with different integration policies and welfare regimes. Analyses show that both parents and peers are relevant predictors of entry into union: More modern parental characteristics and contact with non-coethnic peers result in postponement of union entry. Furthermore, parental and peer influences are found to be rather similar in all seven countries despite a variety of integration policies. Actual timing differences between countries may be caused by welfare state provisions directed at young adults.
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- 2010
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28. Evaluation of discontinuation for adverse events of JAK inhibitors and bDMARDs in an international collaboration of rheumatoid arthritis registers (the 'JAK-pot' study).
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Aymon R, Mongin D, Bergstra SA, Choquette D, Codreanu C, De Cock D, Dreyer L, Elkayam O, Huschek D, Hyrich KL, Iannone F, Inanc N, Kearsley-Fleet L, Koca SS, Kvien TK, Leeb BF, Lukina G, Nordström DC, Pavelka K, Pombo-Suarez M, Rodrigues A, Rotar Z, Strangfeld A, Verschueren P, Westermann R, Zavada J, Courvoisier DS, Finckh A, and Lauper K
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- Humans, Treatment Outcome, Tumor Necrosis Factor-alpha, Tumor Necrosis Factor Inhibitors therapeutic use, Antirheumatic Agents therapeutic use, Janus Kinase Inhibitors therapeutic use, Arthritis, Rheumatoid drug therapy, Azetidines, Purines, Pyrazoles, Sulfonamides
- Abstract
Background: In a clinical trial setting, patients with rheumatoid arthritis (RA) taking the Janus kinase inhibitor (JAKi) tofacitinib demonstrated higher adverse events rates compared with those taking the tumour necrosis factor inhibitors (TNFi) adalimumab or etanercept., Objective: Compare treatment discontinuations for adverse events (AEs) among second-line therapies in an international real-world RA population., Methods: Patients initiating JAKi, TNFi or a biological with another mode of action (OMA) from 17 registers participating in the 'JAK-pot' collaboration were included. The primary outcome was the rate of treatment discontinuation due to AEs. We used unadjusted and adjusted cause-specific Cox proportional hazard models to compare treatment discontinuations for AEs among treatment groups by class, but also evaluating separately the specific type of JAKi., Results: Of the 46 913 treatment courses included, 12 523 were JAKi (43% baricitinib, 40% tofacitinib, 15% upadacitinib, 2% filgotinib), 23 391 TNFi and 10 999 OMA. The adjusted cause-specific hazard rate of treatment discontinuation for AEs was similar for TNFi versus JAKi (1.00, 95% CI 0.92 to 1.10) and higher for OMA versus JAKi (1.11, 95% CI 1.01 to 1.23), lower with TNFi compared with tofacitinib (0.81, 95% CI 0.71 to 0.90), but higher for TNFi versus baricitinib (1.15, 95% CI 1.01 to 1.30) and lower for TNFi versus JAKi in patients 65 or older with at least one cardiovascular risk factor (0.79, 95% CI 0.65 to 0.97)., Conclusion: While JAKi overall were not associated with more treatment discontinuations for AEs, subgroup analyses suggest varying patterns with specific JAKi, such as tofacitinib, compared with TNFi. However, these observations should be interpreted cautiously, given the observational study design., Competing Interests: Competing interests: RA has nothing to disclose. DM has nothing to disclose. SAB reports grants from Pfizer outside of this work and speaker fees from Benecke. DC has nothing to disclose. CC reports reports personal fees from AbbVie, Amgen, Boehringer Ingelheim, Ewopharma, Lilly, Novartis, Pfizer outside the submitted work. DDC has nothing to disclose. LD reports contract with BMS outside the present work. OE reports consulting and speaker fees from AbbVie, Pfizer, Eli Lilly, Novartis and Jansen. DH has nothing to disclose. KLH reports grant support from Pfizer and Bristol Myers Squibb and speaking fees from AbbVie. FI reports consulting fees from AbbVie, Janssen, UCB, Galapagos and speaker fees from AbbVie, Galapagos, Eli Lilly, Pfizer and UCB. NI reports consulting and speaking fees from AbbVie, Novartis, UCB, Eli Lilly, Pfizer and Celltrion. LKF has nothing to disclose. SSK has nothing to disclose. TKK reports grants from AbbVie, BMS, Galapagos, Novartis, Pfizer and UCB, consulting fees from AbbVie, Gilead, Janssen, Novartis, Pfizer, Sandoz, UCB Grünenthal, Sandoz and speaker fees from Grünenthal, Sandoz. BFL reports consulting fees from Eli Lilly, Pfizer and AbbVie, and speaking fees from Sandoz. GL has nothing to disclose. DN reports grants from MSD, consulting fees from BMS, Lilly, Novartis, Pfizer, UCB and speaker fees from Pfizer and UCB. KP reports speaker fees from Novartis, Eli Lilly, Roche, Pfizer, Sobi, AbbVie, Pfizer and MSD. MPS has nothing to disclose. AR reports grants from Amgen, AstraZeneca, Novartis, AbbVie, Pfizer, MSD, Lilly, Boehringer Ingelheim, speaker fees from Amgen, AbbVie and Novartis. ZR reports consulting fees from AbbVie, Pfizer, Janssen, AstraZeneca, Novartis, Boehringer Ingelheim, Eli Lilly and speaker fees from AbbVie, Pfizer, Janssen, AstraZeneca, Novartis, Boehringer Ingelheim, Eli Lilly, SOBI, Lek (Sandoz). AS reports speaker fees from AbbVie, BMC, MSD, Pfizer and Roche. PV reports grants from Pfizer and Galapagos, consulting fees from Galapagos, Gilead, Pfizer, Sidekick Health, speaking fees from Eli Lilly, Galapagos and Roularta. RW has nothing to disclose. JZ reports speaking fees from AbbVie, Sobi, Pfizer and Eli Lilly. DSC reports consulting fees from Medela AG. AF reports grants from AbbVie, Pfizer, Galapagos and Eli Lilly, consulting fees from Eli Lilly, Pfizer, AbbVie, speaker fees from Pfizer, Eli Lilly, AbbVie, MSD and BMS. KL has received consultancy and/or speaker fees from Pfizer, Viatris, Celltrion and Galapagos paid to her institution., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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29. Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration.
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Lauper K, Iudici M, Mongin D, Bergstra SA, Choquette D, Codreanu C, Cordtz R, De Cock D, Dreyer L, Elkayam O, Hauge EM, Huschek D, Hyrich KL, Iannone F, Inanc N, Kearsley-Fleet L, Kristianslund EK, Kvien TK, Leeb BF, Lukina G, Nordström DC, Pavelka K, Pombo-Suarez M, Rotar Z, Santos MJ, Strangfeld A, Verschueren P, Courvoisier DS, and Finckh A
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- Abatacept therapeutic use, Humans, Interleukin-6, Treatment Outcome, Tumor Necrosis Factor Inhibitors, Tumor Necrosis Factor-alpha, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid chemically induced, Arthritis, Rheumatoid drug therapy, Janus Kinase Inhibitors therapeutic use
- Abstract
Background: JAK-inhibitors (JAKi), recently approved in rheumatoid arthritis (RA), have changed the landscape of treatment choices. We aimed to compare the effectiveness of four current second-line therapies of RA with different modes of action, since JAKi approval, in an international collaboration of 19 registers., Methods: In this observational cohort study, patients initiating tumour necrosis factor inhibitors (TNFi), interleukin-6 inhibitors (IL-6i), abatacept (ABA) or JAKi were included. We compared the effectiveness of these treatments in terms of drug discontinuation and Clinical Disease Activity Index (CDAI) response rates at 1 year. Analyses were adjusted for patient, disease and treatment characteristics, including lines of therapy and accounted for competing risk., Results: We included 31 846 treatment courses: 17 522 TNFi, 2775 ABA, 3863 IL-6i and 7686 JAKi. Adjusted analyses of overall discontinuation were similar across all treatments. The main single reason of stopping treatment was ineffectiveness. Compared with TNFi, JAKi were less often discontinued for ineffectiveness (adjusted HR (aHR) 0.75, 95% CI 0.67 to 0.83), as was IL-6i (aHR 0.76, 95% CI 0.67 to 0.85) and more often for adverse events (aHR 1.16, 95% CI 1.03 to 1.33). Adjusted CDAI response rates at 1 year were similar between TNFi, JAKi and IL-6i and slightly lower for ABA., Conclusion: The adjusted overall drug discontinuation and 1 year response rates of JAKi and IL-6i were similar to those observed with TNFi. Compared with TNFi, JAKi were more often discontinued for adverse events and less for ineffectiveness, as were IL-6i., Competing Interests: Competing interests: KL reports personal fees from Gilead-Galapagos, Pfizer, Viatris, Celltrion, outside the submitted work. ML reports speaking fee from Boehringer Inghelheim, outside the submitted work. DM has nothing to disclose. SAB report grants from Pfizer, outside the submitted work. DC report grants, personal fees and non-financial support from Abbvie, grants, personal fees and non-financial support from Amgen, grants, personal fees and non-financial support from BMS, grants, personal fees and non-financial support from Eli Lilly, grants, personal fees and non-financial support from Merck, grants, personal fees and non-financial support from Novartis, grants, personal fees and non-financial support from Pfizer, grants, personal fees and non-financial support from Roche, grants, personal fees and non-financial support from Sanofi-Genzyme, grants, personal fees and non-financial support from UCB, grants, personal fees and non-financial support from Sandoz, outside the submitted work. CC reports personal fees from Abbvie, Amgen, Boehringer Ingelheim, Ewopharma, Lilly, Novartis, Pfizer outside the submitted work. RC has nothing to disclose. DDC has nothing to disclose. LD reports institutional grant from BMS outside the present work and speakers bureau from Eli Lilly and Galderma. OE has nothing to disclose. E-MH reports personal fees from AbbVie, Sanofi, Sobi ; institutional grants from Novo Nordic Foundation, Danish Rheumatism Association, Danish Regions Medicine Grants, Roche, Novartis, AbbVie outside the submitted work. DH has nothing to discloseKLH reports honoraria from Abbvie and grants from Pfizer and BMS outside the submitted work, and is supported by the NIHR Manchester Biomedical Research Centre. FI reports speaking fees from Abbvie, BMS, Eli-Lilly, Roche, MSD, Galapagos, Pfizer, Celltrion, Janssen outside the submitted work. NI reports grants from Roche, Pfizer, personal fees from AbbVie, Roche, Pfizer, UCB, Novartis,Amgen, Lilly, MSD. LK-F has nothing to disclose. EKK has nothing to disclose. TKK reports fees for speaking and/or consulting last 2 years from AbbVie, Amgen, Celltrion, Egis, Evapharma, Ewopharma, Gilead, Hikma, Janssen, Mylan, Novartis, Oktal, Pfizer, Sandoz, UCB. BFL reports personal fees from Abbvie, personal fees from Biogen, personal fees from Celgene, personal fees from Eli Lilly, personal fees from MSD, personal fees from Pfizer, personal fees from Roche, and personal fees from Novartis and Sandoz. GL reports personal fees from Abbvie, personal fees from Eli Lilly, personal fees from MSD, personal fees from Novartis, personal fees from Pfizer, personal fees from Roche, personal fees from Janssen, personal fees from BMS, outside the submitted work. DCN reports grants from Roche, during the conduct of the study; personal fees from Abbvie, personal fees from BMS, grants from Celgene, personal fees from Lilly, grant from MSD, personal fees from Novartis, personal fees from Pfizer, personal fees from UCB, outside the submitted work. KP has received honoraria for lectures and consultations from: AbbVie, BMS, Egis, Roche, Amgen, MSD, Medac, Eli Lilly, Pfizer. MPS reports personal fees from Janssen, MSD, Sanofi, outside the submitted work. ZR honoraria for lectures and consultations from: Abbvie, Pfizer, MSD, Medis, Roche, outside the submitted work. MJS reports personal fees from AbbVie, personal fees from Pfizer, personal fees from Novartis, personal fees from Roche, outside the submitted work. AS reports speaker honoraria from AbbVie, BMS, MSD, Pfizer, and Roche. PV reports speakers bureau for Eli Lilly, MSD, Galapagos, Roularta, consultancy fees from Galapagos, Gilead, Pfizer, Sanofi, Sidekick Health, Eli Lilly, Nordic Pharma, ABBVIE, Celltrion, BMS, UCB and is the grant holder from the Pfizer Chair Management of Early Rheumatoid Arthritis at KU Leuven. DSC has nothing to disclose. AF reports grants from AbbVie, BMS, Eli-Lilly, Galapagos and Pfizer and speaker honoraria (educational events or symposia) from companies producing several of the targeted therapies that are included in this analysis (honoraria < 10’000 USD): AbbVie, BMS, Eli-Lilly, Gilead, MSD, Pfizer. Clinical work in Czech Republic was partially supported by the project from the Ministry of Health for conceptual development of research organisation MZ00023728023728 (Institute of Rheumatology). BIOBADASER has received funding from Fundacion Española de Reumatología, the Spanish Medicines and Health Products Agency (Agencia Española del Medicamento y Productos Sanitarios) and equal grants from pharmaceutical companies (AbbVie, BMS, Celltrion, Galapagos, Janssen, Lilly, MSD, Novartis, Pfizer, Regeneron, Roche, Samsung, Schering‐Plough and UCB). BioRx.si has received funding for clinical research paid to Društvo za razvoj revmatologije from AbbVie, Roche, Medis, MSD, Biogen, Amgen, Sanofi, Celgene and Pfizer. The British Society for Rheumatology Biologics Register in Rheumatoid Arthritis (BSRBR-RA) is funded by a grant from the British Society for Rheumatology (BSR). The BSR currently receives funding from Abbvie, Amgen, Celltrion HC, Eli Lilly, Pfizer, Samsung Bioepis, Sanofi, Sandoz and in the past Hospira, MSD, Roche, SOBI and UCB. This income finances a wholly separate contract between the BSR and The University of Manchester to host the BSRBR-RA. All decisions concerning study design, data capture, analyses, interpretation and publication are made autonomously of any industrial contribution. The BSRBR-RA would like to gratefully acknowledge the support of the National Institute for Health Research, through the Local Clinical Research Networks in England (and equivalent organisations in the devolved nations) at participating centres and the BSRBR-RA Control Centre Consortium. DANBIO was partially supported by public and private funding (AbbVie, Biogen, Bristol Myers Squibb, Eli Lilly, MSD, Novartis, Pfizer, Roche, Sanofi, UCB). NOR-DMARD was has been supported with research funding to Diakonhjemmet Hospital from AbbVie, Amgen, BMS, MSD, Novartis, Pfizer and UCB. The RABBIT register is currently supported by an unconditional grant with equal parts from AbbVie, Amgen, BMS, Celltrion, Fresenius Kabi, Galapagos, Hexal, Lilly, MSD, Viatris, Pfizer, Roche, Samsung Bioepis, Sanofi-Aventis, and UCB. REUMA. PT is supported by unrestricted grants from Abbvie, Biogen, Celgene, MSD, Roche, Sanofi and Pfizer. ROB-FIN is funded by AbbVie, Hospira, BMS, MSD, Pfizer, Roche and UCB. The Romanian Registry of Rheumatic Diseases (RRBR) uses unrestricted grants from AbbVie, Pfizer, Eli Lilly, Ewopharma, Nopvartis MSD, Roche, UCB, and BMS. Swiss Clinical Quality Management in Rheumatic Diseases (SCQM) database is sponsored by public and industrial support (http://scqm.ch/en/sponsoren/)., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
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30. Rapid dereplication of microbial isolates using matrix-assisted laser desorption ionization time-of-flight mass spectrometry: A mini-review.
- Author
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Huschek D and Witzel K
- Abstract
Matrix-Assisted Laser Desorption Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF MS) has become one of the most popular methods for the rapid, cost-effective and accurate classification and characterization of cultivable microorganisms. Due to its simple sample preparation and short measurement time, MALDI-TOF MS is an excellent choice for the high-throughput study of microbial isolates from rhizospheres or plants grown under diverse environmental conditions. While clinical isolates have a higher identification rate than environmental isolates due to the focus of commercial mass spectral libraries on the former, no identification is necessary in the dereplication step of large environmental studies. The grouping of large sets of isolates according to their intact protein profiles can be performed without knowledge of their taxonomy. Thus, this method is easily applicable to environmental samples containing microorganisms from yet undescribed phylogenetic origins. The main strategies applied to achieve effective dereplication are, first, expanding existing mass spectral libraries and, second, using an additional statistical analysis step to group measured mass spectra and identify unique isolates. In this review, these aspects are addressed. It closes with a prospective view on how MALDI-TOF MS-based microbial characterisation can accelerate the exploitation of plant-associated microbiota.
- Published
- 2019
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31. Partner Choice Patterns Among the Descendants of Turkish Immigrants in Europe.
- Author
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Huschek D, de Valk HA, and Liefbroer AC
- Abstract
We examine the partner choice patterns of second-generation Turks in 13 European cities in seven countries. We not only compare intermarriage versus endogamous marriage, but also explicitly include the choice of a second-generation partner of the same origin and of a partner of other migrant origin as important alternatives. In Europe, populations are made up increasingly of migrants and their descendants resulting in new alternative partner options not open before. Findings suggest that second-generation Turks who choose a second-generation partner seem to be located between the partner choice of a first-generation and native partner in terms of family values and contact to non-coethnic peers. The choice of a partner of other migrant origin hardly differs in these characteristics from the choice of a native partner. Context variables such as group size and type of integration policies seem to play a role for the likelihood of having a first-generation versus a second-generation partner of Turkish origin but not for the likelihood of exogamous partner choice. A second-generation partner is the most popular choice in Germany but represents a minor option in the other countries. Furthermore, a partner of other migrant origin is more common among men but is in some countries more popular than a native partner among Turkish second-generation men and women.
- Published
- 2012
- Full Text
- View/download PDF
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