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2. Impact of the COVID-19 pandemic on the homeless: results from a retrospective closed cohort in France (March–May 2020)

Author

Husain, Maya, primary, Rachline, Anne, additional, Cousien, Anthony, additional, Rolland, Simon, additional, Rouzaud, Claire, additional, Ferre, Valentine Marie, additional, Gomez, Maria Vargas, additional, Le Teurnier, Maï, additional, Wicky-Thisse, Marie, additional, Descamps, Diane, additional, Yazdanpanah, Yazdan, additional, Charpentier, Charlotte, additional, and Pasquet-Cadre, Armelle, additional

Published
2021
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5. Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

Author

Bastard, Paul, Gervais, Adrian, Taniguchi, Maki, Saare, Liisa, Särekannu, Karita, Le Voyer, Tom, Philippot, Quentin, Rosain, Jérémie, Bizien, Lucy, Asano, Takaki, Garcia-Prat, Marina, Parra-Martínez, Alba, Migaud, Mélanie, Tsumura, Miyuki, Conti, Francesca, Belot, Alexandre, Rivière, Jacques G., Morio, Tomohiro, Tanaka, Junko, Javouhey, Etienne, Haerynck, Filomeen, Duvlis, Sotirija, Ozcelik, Tayfun, Keles, Sevgi, Tandjaoui-Lambiotte, Yacine, Escoda, Simon, Husain, Maya, Pan-Hammarström, Qiang, Hammarström, Lennart, Ahlijah, Gloria, Abi Haidar, Anthony, Soudee, Camille, Arseguel, Vincent, Abolhassani, Hassan, Sahanic, Sabina, Tancevski, Ivan, Nukui, Yoko, Hayakawa, Seiichi, Chrousos, George P., Michos, Athanasios, Tatsi, Elizabeth-Barbara, Filippatos, Filippos, Rodriguez-Palmero, Agusti, Troya, Jesus, Tipu, Imran, Meyts, Isabelle, Roussel, Lucie, Ostrowski, Sisse Rye, Schidlowski, Laire, Prando, Carolina, Condino-Neto, Antonio, Cheikh, Nathalie, Bousfiha, Ahmed A., El Bakkouri, Jalila, Peterson, Pärt, Pujol, Aurora, Lévy, Romain, Quartier, Pierre, Vinh, Donald C., Boisson, Bertrand, Béziat, Vivien, Zhang, Shen-Ying, Borghesi, Alessandro, Pession, Andrea, Andreakos, Evangelos, Marr, Nico, Mentis, Alexios-Fotios A., Mogensen, Trine H., Rodríguez-Gallego, Carlos, Soler-Palacin, Pere, Colobran, Roger, Tillmann, Vallo, Neven, Bénédicte, Trouillet-Assant, Sophie, Brodin, Petter, Abel, Laurent, Jouanguy, Emmanuelle, Zhang, Qian, Martinón-Torres, Federico, Salas, Antonio, Gómez-Carballa, Alberto, Gonzalez-Granado, Luis I., Kisand, Kai, Okada, Satoshi, Puel, Anne, Cobat, Aurélie, and Casanova, Jean-Laurent

Abstract

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2.

Published
2024
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6. Tularemia in Pediatric Patients: A Case Series and Review of the Literature.

Author

Kossadoum RF, Baron A, Parizot M, Husain M, Poey N, Maurin M, Caspar Y, Caseris M, Bidet P, and Bonacorsi S

Abstract

Background: Unfamiliar to pediatricians, tularemia can lead to delays in diagnosis and hinder appropriate treatment, as its clinical presentation often shares similarities with other more prevalent causes of lymphadenopathy diseases in children. We conducted a comprehensive literature review to offer contemporary insights into the clinical manifestations and treatment strategies for tularemia infection in children., Methods: Three cases of glandular tularemia were diagnosed in the Pediatric Robert Debré Hospital (Paris) between October 2020 and February 2022. In addition, we conducted a literature search using PubMed in December 2023 of cases of tularemia in children published in English., Results: The 94 cases of the literature review highlight the large age range (from 6 weeks to 17 years) and multiple sources of infection, including diverse zoonotic transmission (86.7%) and contact with contaminated water (13.3%). Fever was a consistent symptom. Ulceroglandular (46.7%), glandular (17%) and oropharyngeal forms (18.1%) predominated. The most frequently used diagnostic method was serology (60.6%). The median time to diagnosis for tularemia was 23.5 days. Hospitalization was required in 63.2% of cases, with a median duration of 4 days. Targeted treatment was based on aminoglycosides (37.6%), fluoroquinolones (30.6%) or tetracyclines (12.9%), in accordance with WHO recommendations, with a mainly favorable outcome, although several cases of meningitis were observed., Conclusion: Pediatricians should be aware of the etiology of this febrile lymphadenopathy, notably when experiencing beta-lactam treatment failure, even in young infants, which could help reduce the extra costs associated with inappropriate antibiotic use and hospitalization., Competing Interests: The authors have no funding or conflicts of interest to disclose., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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7. First Case of Mild Encephalopathy with Reversible Splenial Lesion in SARS-CoV-2 Infection.

Author

Chauffier J, Poey N, Husain M, Broucker T, Khalil A, Lariven S, and Henry-Feugeas MC

Subjects
Brain Diseases virology, Brain Edema diagnostic imaging, Brain Edema virology, Cerebrovascular Circulation, Corpus Callosum diagnostic imaging, Corpus Callosum virology, Humans, Male, Middle Aged, SARS-CoV-2, Treatment Outcome, Brain Diseases etiology, COVID-19 complications
Published
2021
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