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Your search keyword '"Hurov, Kristen E."' showing total 31 results
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31 results on '"Hurov, Kristen E."'

1. Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

Author

McDonald, E. Robert, III, de Weck, Antoine, Schlabach, Michael R., Billy, Eric, Mavrakis, Konstantinos J., Hoffman, Gregory R., Belur, Dhiren, Castelletti, Deborah, Frias, Elizabeth, Gampa, Kalyani, Golji, Javad, Kao, Iris, Li, Li, Megel, Philippe, Perkins, Thomas A., Ramadan, Nadire, Ruddy, David A., Silver, Serena J., Sovath, Sosathya, Stump, Mark, Weber, Odile, Widmer, Roland, Yu, Jianjun, Yu, Kristine, Yue, Yingzi, Abramowski, Dorothee, Ackley, Elizabeth, Barrett, Rosemary, Berger, Joel, Bernard, Julie L., Billig, Rebecca, Brachmann, Saskia M., Buxton, Frank, Caothien, Roger, Caushi, Justina X., Chung, Franklin S., Cortés-Cros, Marta, deBeaumont, Rosalie S., Delaunay, Clara, Desplat, Aurore, Duong, William, Dwoske, Donald A., Eldridge, Richard S., Farsidjani, Ali, Feng, Fei, Feng, JiaJia, Flemming, Daisy, Forrester, William, Galli, Giorgio G., Gao, Zhenhai, Gauter, François, Gibaja, Veronica, Haas, Kristy, Hattenberger, Marc, Hood, Tami, Hurov, Kristen E., Jagani, Zainab, Jenal, Mathias, Johnson, Jennifer A., Jones, Michael D., Kapoor, Avnish, Korn, Joshua, Liu, Jilin, Liu, Qiumei, Liu, Shumei, Liu, Yue, Loo, Alice T., Macchi, Kaitlin J., Martin, Typhaine, McAllister, Gregory, Meyer, Amandine, Mollé, Sandra, Pagliarini, Raymond A., Phadke, Tanushree, Repko, Brian, Schouwey, Tanja, Shanahan, Frances, Shen, Qiong, Stamm, Christelle, Stephan, Christine, Stucke, Volker M., Tiedt, Ralph, Varadarajan, Malini, Venkatesan, Kavitha, Vitari, Alberto C., Wallroth, Marco, Weiler, Jan, Zhang, Jing, Mickanin, Craig, Myer, Vic E., Porter, Jeffery A., Lai, Albert, Bitter, Hans, Lees, Emma, Keen, Nicholas, Kauffmann, Audrey, Stegmeier, Frank, Hofmann, Francesco, Schmelzle, Tobias, and Sellers, William R.

Published
2017
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2. Supplementary Tables from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., primary, Hurov, Kristen E., primary, Tamayo, Pablo, primary, Creighton, Chad J., primary, Sonkin, Dmitriy, primary, Giacomelli, Andrew O., primary, Du, Charles, primary, Fries, Daniel F., primary, Wong, Kwok-Kin, primary, Mesirov, Jill P., primary, Loeffler, Jay S., primary, Schreiber, Stuart L., primary, Hammerman, Peter S., primary, and Meyerson, Matthew, primary

Published
2023
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3. Supplementary Figure 2 from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., primary, Hurov, Kristen E., primary, Tamayo, Pablo, primary, Creighton, Chad J., primary, Sonkin, Dmitriy, primary, Giacomelli, Andrew O., primary, Du, Charles, primary, Fries, Daniel F., primary, Wong, Kwok-Kin, primary, Mesirov, Jill P., primary, Loeffler, Jay S., primary, Schreiber, Stuart L., primary, Hammerman, Peter S., primary, and Meyerson, Matthew, primary

Published
2023
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4. Supplementary Figure Legends from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., primary, Hurov, Kristen E., primary, Tamayo, Pablo, primary, Creighton, Chad J., primary, Sonkin, Dmitriy, primary, Giacomelli, Andrew O., primary, Du, Charles, primary, Fries, Daniel F., primary, Wong, Kwok-Kin, primary, Mesirov, Jill P., primary, Loeffler, Jay S., primary, Schreiber, Stuart L., primary, Hammerman, Peter S., primary, and Meyerson, Matthew, primary

Published
2023
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5. Supplementary Figures 1 - 6 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling

Author

Schoumacher, Marie, primary, Hurov, Kristen E., primary, Lehár, Joseph, primary, Yan-Neale, Yan, primary, Mishina, Yuji, primary, Sonkin, Dmitriy, primary, Korn, Joshua M., primary, Flemming, Daisy, primary, Jones, Michael D., primary, Antonakos, Brandon, primary, Cooke, Vesselina G., primary, Steiger, Janine, primary, Ledell, Jebediah, primary, Stump, Mark D., primary, Sellers, William R., primary, Danial, Nika N., primary, and Shao, Wenlin, primary

Published
2023
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6. Supplementary Materials, Figure Legends, Table Legends from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling

Author

Schoumacher, Marie, primary, Hurov, Kristen E., primary, Lehár, Joseph, primary, Yan-Neale, Yan, primary, Mishina, Yuji, primary, Sonkin, Dmitriy, primary, Korn, Joshua M., primary, Flemming, Daisy, primary, Jones, Michael D., primary, Antonakos, Brandon, primary, Cooke, Vesselina G., primary, Steiger, Janine, primary, Ledell, Jebediah, primary, Stump, Mark D., primary, Sellers, William R., primary, Danial, Nika N., primary, and Shao, Wenlin, primary

Published
2023
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7. Data from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., primary, Hurov, Kristen E., primary, Tamayo, Pablo, primary, Creighton, Chad J., primary, Sonkin, Dmitriy, primary, Giacomelli, Andrew O., primary, Du, Charles, primary, Fries, Daniel F., primary, Wong, Kwok-Kin, primary, Mesirov, Jill P., primary, Loeffler, Jay S., primary, Schreiber, Stuart L., primary, Hammerman, Peter S., primary, and Meyerson, Matthew, primary

Published
2023
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8. Data from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling

Author

Schoumacher, Marie, primary, Hurov, Kristen E., primary, Lehár, Joseph, primary, Yan-Neale, Yan, primary, Mishina, Yuji, primary, Sonkin, Dmitriy, primary, Korn, Joshua M., primary, Flemming, Daisy, primary, Jones, Michael D., primary, Antonakos, Brandon, primary, Cooke, Vesselina G., primary, Steiger, Janine, primary, Ledell, Jebediah, primary, Stump, Mark D., primary, Sellers, William R., primary, Danial, Nika N., primary, and Shao, Wenlin, primary

Published
2023
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9. Supplementary Figure 7 from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., primary, Hurov, Kristen E., primary, Tamayo, Pablo, primary, Creighton, Chad J., primary, Sonkin, Dmitriy, primary, Giacomelli, Andrew O., primary, Du, Charles, primary, Fries, Daniel F., primary, Wong, Kwok-Kin, primary, Mesirov, Jill P., primary, Loeffler, Jay S., primary, Schreiber, Stuart L., primary, Hammerman, Peter S., primary, and Meyerson, Matthew, primary

Published
2023
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10. Supplementary Figure 1 from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., primary, Hurov, Kristen E., primary, Tamayo, Pablo, primary, Creighton, Chad J., primary, Sonkin, Dmitriy, primary, Giacomelli, Andrew O., primary, Du, Charles, primary, Fries, Daniel F., primary, Wong, Kwok-Kin, primary, Mesirov, Jill P., primary, Loeffler, Jay S., primary, Schreiber, Stuart L., primary, Hammerman, Peter S., primary, and Meyerson, Matthew, primary

Published
2023
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11. Supplementary Figure 6 from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., primary, Hurov, Kristen E., primary, Tamayo, Pablo, primary, Creighton, Chad J., primary, Sonkin, Dmitriy, primary, Giacomelli, Andrew O., primary, Du, Charles, primary, Fries, Daniel F., primary, Wong, Kwok-Kin, primary, Mesirov, Jill P., primary, Loeffler, Jay S., primary, Schreiber, Stuart L., primary, Hammerman, Peter S., primary, and Meyerson, Matthew, primary

Published
2023
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12. Supplementary Methods and References from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., primary, Hurov, Kristen E., primary, Tamayo, Pablo, primary, Creighton, Chad J., primary, Sonkin, Dmitriy, primary, Giacomelli, Andrew O., primary, Du, Charles, primary, Fries, Daniel F., primary, Wong, Kwok-Kin, primary, Mesirov, Jill P., primary, Loeffler, Jay S., primary, Schreiber, Stuart L., primary, Hammerman, Peter S., primary, and Meyerson, Matthew, primary

Published
2023
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13. Supplementary Figure 4 from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., primary, Hurov, Kristen E., primary, Tamayo, Pablo, primary, Creighton, Chad J., primary, Sonkin, Dmitriy, primary, Giacomelli, Andrew O., primary, Du, Charles, primary, Fries, Daniel F., primary, Wong, Kwok-Kin, primary, Mesirov, Jill P., primary, Loeffler, Jay S., primary, Schreiber, Stuart L., primary, Hammerman, Peter S., primary, and Meyerson, Matthew, primary

Published
2023
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14. Supplementary Table 1 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling

Author

Schoumacher, Marie, primary, Hurov, Kristen E., primary, Lehár, Joseph, primary, Yan-Neale, Yan, primary, Mishina, Yuji, primary, Sonkin, Dmitriy, primary, Korn, Joshua M., primary, Flemming, Daisy, primary, Jones, Michael D., primary, Antonakos, Brandon, primary, Cooke, Vesselina G., primary, Steiger, Janine, primary, Ledell, Jebediah, primary, Stump, Mark D., primary, Sellers, William R., primary, Danial, Nika N., primary, and Shao, Wenlin, primary

Published
2023
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15. Supplementary Table 3 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling

Author

Schoumacher, Marie, primary, Hurov, Kristen E., primary, Lehár, Joseph, primary, Yan-Neale, Yan, primary, Mishina, Yuji, primary, Sonkin, Dmitriy, primary, Korn, Joshua M., primary, Flemming, Daisy, primary, Jones, Michael D., primary, Antonakos, Brandon, primary, Cooke, Vesselina G., primary, Steiger, Janine, primary, Ledell, Jebediah, primary, Stump, Mark D., primary, Sellers, William R., primary, Danial, Nika N., primary, and Shao, Wenlin, primary

Published
2023
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16. Supplementary Table 5 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling

Author

Schoumacher, Marie, primary, Hurov, Kristen E., primary, Lehár, Joseph, primary, Yan-Neale, Yan, primary, Mishina, Yuji, primary, Sonkin, Dmitriy, primary, Korn, Joshua M., primary, Flemming, Daisy, primary, Jones, Michael D., primary, Antonakos, Brandon, primary, Cooke, Vesselina G., primary, Steiger, Janine, primary, Ledell, Jebediah, primary, Stump, Mark D., primary, Sellers, William R., primary, Danial, Nika N., primary, and Shao, Wenlin, primary

Published
2023
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17. Supplementary Table 2 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling

Author

Schoumacher, Marie, primary, Hurov, Kristen E., primary, Lehár, Joseph, primary, Yan-Neale, Yan, primary, Mishina, Yuji, primary, Sonkin, Dmitriy, primary, Korn, Joshua M., primary, Flemming, Daisy, primary, Jones, Michael D., primary, Antonakos, Brandon, primary, Cooke, Vesselina G., primary, Steiger, Janine, primary, Ledell, Jebediah, primary, Stump, Mark D., primary, Sellers, William R., primary, Danial, Nika N., primary, and Shao, Wenlin, primary

Published
2023
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18. Supplementary Table 4 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling

Author

Schoumacher, Marie, primary, Hurov, Kristen E., primary, Lehár, Joseph, primary, Yan-Neale, Yan, primary, Mishina, Yuji, primary, Sonkin, Dmitriy, primary, Korn, Joshua M., primary, Flemming, Daisy, primary, Jones, Michael D., primary, Antonakos, Brandon, primary, Cooke, Vesselina G., primary, Steiger, Janine, primary, Ledell, Jebediah, primary, Stump, Mark D., primary, Sellers, William R., primary, Danial, Nika N., primary, and Shao, Wenlin, primary

Published
2023
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19. Supplementary Figure 5 from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., primary, Hurov, Kristen E., primary, Tamayo, Pablo, primary, Creighton, Chad J., primary, Sonkin, Dmitriy, primary, Giacomelli, Andrew O., primary, Du, Charles, primary, Fries, Daniel F., primary, Wong, Kwok-Kin, primary, Mesirov, Jill P., primary, Loeffler, Jay S., primary, Schreiber, Stuart L., primary, Hammerman, Peter S., primary, and Meyerson, Matthew, primary

Published
2023
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24. A role for proapoptotic BID in the DNA-damage response

Author

Zinkel, Sandra S., Hurov, Kristen E., Ong, Christy, Abtahi, Farvardean M., Gross, Atan, and Korsmeyer, Stanley J.

Subjects
DNA damage -- Research, Genetic research, Biological sciences
Abstract

BID has an unexpected role in the intra-S phase checkpoint downstream of DNA damage distinct from its proapoptotic function. The DNA-damage kinase ATM mediates this role through BID phosphorylation and these results establish a link between proapoptotic BID and the DNA-damage response.

Published
2005

25. Abstract 3257: Activation of CD137 using multivalent and tumor targeted Bicyclic peptides

Author

Hurov, Kristen E., primary, Upadhyaya, Punit, additional, Kublin, Jessica, additional, Zhou, Xueyuan, additional, Kristensson, Julia, additional, Lani, Rachid, additional, Mudd, Gemma, additional, Rietschoten, Katerine van, additional, An, Frank, additional, Lahdenranta, Johanna, additional, Chen, Liuhong, additional, Bennett, Gavin, additional, McDonnell, Kevin, additional, Park, Peter, additional, and Keen, Nicholas, additional

Published
2019
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26. Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling

Author

Schoumacher, Marie, primary, Hurov, Kristen E., additional, Lehár, Joseph, additional, Yan-Neale, Yan, additional, Mishina, Yuji, additional, Sonkin, Dmitriy, additional, Korn, Joshua M., additional, Flemming, Daisy, additional, Jones, Michael D., additional, Antonakos, Brandon, additional, Cooke, Vesselina G., additional, Steiger, Janine, additional, Ledell, Jebediah, additional, Stump, Mark D., additional, Sellers, William R., additional, Danial, Nika N., additional, and Shao, Wenlin, additional

Published
2014
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27. Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer

Author

Abazeed, Mohamed E., primary, Adams, Drew J., additional, Hurov, Kristen E., additional, Tamayo, Pablo, additional, Creighton, Chad J., additional, Sonkin, Dmitriy, additional, Giacomelli, Andrew O., additional, Du, Charles, additional, Fries, Daniel F., additional, Wong, Kwok-Kin, additional, Mesirov, Jill P., additional, Loeffler, Jay S., additional, Schreiber, Stuart L., additional, Hammerman, Peter S., additional, and Meyerson, Matthew, additional

Published
2013
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31. Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion.

Author

Gwanghee Lee, White, Lynn S., Hurov, Kristen E., Stappenbeck, Thaddeus S., and Piwnica-Worms, Helen

Subjects
EPITHELIAL cells, CELL division, PHOSPHOPROTEIN phosphatases, ESTERASES, CELL cycle, CANCER
Abstract

The CDC25 protein phosphatases (CDC25A, B, and C) drive cell cycle transitions by activating key components of the cell cycle engine. CDC25A and CDC25B are frequently overproduced in human cancers. Disruption of Cdc25B or Cdc2SC individually or in combination has no effect on mouse viability. Here we report that CDC25A is the only family member to provide an essential function during early embryonic development, and that other family members compensate for its loss in adult mice. In contrast, conditional disruption of the entire family is lethal in adults due to a loss of small intestinal epithelial cell proliferation in crypts of Lieberkühn. Cdc25 loss induced Wnt signaling, and overall crypt structures were preserved. In the face of continuous Wnt signaling, nearly all crypt epithelial progenitors differentiated into multiple cell lineages, including crypt base columnar cells, a proposed stem cell. A small population of Musashi/Dcamkl-1/nuclearβ-catenin-positive epithelial cells was retained in these crypts. These findings have implications for the development of novel; less cytotoxic cancer chemotherapeutic drugs that specifically target the cell cycle. [ABSTRACT FROM AUTHOR]

Published
2009
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