Search

Your search keyword '"Huppertz, Charlotte"' showing total 35 results
Start Over Author "Huppertz, Charlotte"
35 results on '"Huppertz, Charlotte"'

1. Predictors of adherence to exercise interventions in people with schizophrenia

Author

Schwaiger, Rebecca, Maurus, Isabel, Lembeck, Moritz, Papazova, Irina, Greska, David, Muenz, Susanne, Sykorova, Eliska, Thieme, Cristina E., Vogel, Bob O., Mohnke, Sebastian, Huppertz, Charlotte, Roeh, Astrid, Keller-Varady, Katriona, Malchow, Berend, Walter, Henrik, Wolfarth, Bernd, Wölwer, Wolfgang, Henkel, Karsten, Hirjak, Dusan, Schmitt, Andrea, Hasan, Alkomiet, Meyer-Lindenberg, Andreas, Falkai, Peter, and Roell, Lukas

Published
2024
Full Text
View/download PDF

2. Step away from depression—results from a multicenter randomized clinical trial with a pedometer intervention during and after inpatient treatment of depression

Author

Große, Julia, Huppertz, Charlotte, Röh, Astrid, Oertel, Viola, Andresen, Sara, Schade, Niklas, Goerke-Arndt, Franziska, Kastinger, Anna, Schoofs, Nikola, Thomann, Philipp Arthur, Henkel, Karsten, Malchow, Berend, Plag, Jens, Terziska, Aleksandra, Brand, Ralf, Helmig, Frank, Schorb, Alexander, Wedekind, Dirk, Jockers-Scherübl, Maria, Schneider, Frank, Petzold, Moritz Bruno, and Ströhle, Andreas

Published
2024
Full Text
View/download PDF

4. Exercise as an add-on treatment in individuals with schizophrenia: Results from a large multicenter randomized controlled trial

Author

Maurus, Isabel, Roell, Lukas, Lembeck, Moritz, Papazova, Irina, Greska, David, Muenz, Susanne, Wagner, Elias, Campana, Mattia, Schwaiger, Rebecca, Schneider-Axmann, Thomas, Rosenberger, Kerstin, Hellmich, Martin, Sykorova, Eliska, Thieme, Cristina E., Vogel, Bob O., Harder, Carolin, Mohnke, Sebastian, Huppertz, Charlotte, Roeh, Astrid, Keller-Varady, Katriona, Malchow, Berend, Walter, Henrik, Wolfarth, Bernd, Wölwer, Wolfgang, Henkel, Karsten, Hirjak, Dusan, Schmitt, Andrea, Hasan, Alkomiet, Meyer-Lindenberg, Andreas, and Falkai, Peter

Published
2023
Full Text
View/download PDF

5. Uncovering the hidden effects of repetitive subconcussive head impact exposure: A mega‐analytic approach characterizing seasonal brain microstructural changes in contact and collision sports athletes.

Author

Kwiatkowski, Anna, Weidler, Carmen, Habel, Ute, Coverdale, Nicole S., Hirad, Adnan A., Manning, Kathryn Y., Rauscher, Alexander, Bazarian, Jeffrey J., Cook, Douglas J., Li, David K. B., Mahon, Bradford Z., Menon, Ravi S., Taunton, Jack, Reetz, Kathrin, Romanzetti, Sandro, and Huppertz, Charlotte

Subjects
DIFFUSION magnetic resonance imaging, DIFFUSION tensor imaging, HEAD injuries, WHITE matter (Nerve tissue), BRAIN injuries
Abstract

Repetitive subconcussive head impacts (RSHI) are believed to induce sub‐clinical brain injuries, potentially resulting in cumulative, long‐term brain alterations. This study explores patterns of longitudinal brain white matter changes across sports with RSHI‐exposure. A systematic literature search identified 22 datasets with longitudinal diffusion magnetic resonance imaging data. Four datasets were centrally pooled to perform uniform quality control and data preprocessing. A total of 131 non‐concussed active athletes (American football, rugby, ice hockey; mean age: 20.06 ± 2.06 years) with baseline and post‐season data were included. Nonparametric permutation inference (one‐sample t tests, one‐sided) was applied to analyze the difference maps of multiple diffusion parameters. The analyses revealed widespread lateralized patterns of sports‐season‐related increases and decreases in mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) across spatially distinct white matter regions. Increases were shown across one MD‐cluster (3195 voxels; mean change: 2.34%), one AD‐cluster (5740 voxels; mean change: 1.75%), and three RD‐clusters (817 total voxels; mean change: 3.11 to 4.70%). Decreases were shown across two MD‐clusters (1637 total voxels; mean change: −1.43 to −1.48%), two RD‐clusters (1240 total voxels; mean change: −1.92 to −1.93%), and one AD‐cluster (724 voxels; mean change: −1.28%). The resulting pattern implies the presence of strain‐induced injuries in central and brainstem regions, with comparatively milder physical exercise‐induced effects across frontal and superior regions of the left hemisphere, which need further investigation. This article highlights key considerations that need to be addressed in future work to enhance our understanding of the nature of observed white matter changes, improve the comparability of findings across studies, and promote data pooling initiatives to allow more detailed investigations (e.g., exploring sex‐ and sport‐specific effects). [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

Author

Graff, Mariaelisa, Scott, Robert A, Justice, Anne E, Young, Kristin L, Feitosa, Mary F, Barata, Llilda, Winkler, Thomas W, Chu, Audrey Y, Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L, den Hoed, Marcel, Ahluwalia, Tarunveer S, Qi, Qibin, Ngwa, Julius S, Renström, Frida, Quaye, Lydia, Eicher, John D, Hayes, James E, Cornelis, Marilyn, Kutalik, Zoltan, Lim, Elise, Luan, Jian'an, Huffman, Jennifer E, Zhang, Weihua, Zhao, Wei, Griffin, Paula J, Haller, Toomas, Ahmad, Shafqat, Marques-Vidal, Pedro M, Bien, Stephanie, Yengo, Loic, Teumer, Alexander, Smith, Albert Vernon, Kumari, Meena, Harder, Marie Neergaard, Justesen, Johanne Marie, Kleber, Marcus E, Hollensted, Mette, Lohman, Kurt, Rivera, Natalia V, Whitfield, John B, Zhao, Jing Hua, Stringham, Heather M, Lyytikäinen, Leo-Pekka, Huppertz, Charlotte, Willemsen, Gonneke, Peyrot, Wouter J, Wu, Ying, Kristiansson, Kati, Demirkan, Ayse, Fornage, Myriam, Hassinen, Maija, Bielak, Lawrence F, Cadby, Gemma, Tanaka, Toshiko, Mägi, Reedik, van der Most, Peter J, Jackson, Anne U, Bragg-Gresham, Jennifer L, Vitart, Veronique, Marten, Jonathan, Navarro, Pau, Bellis, Claire, Pasko, Dorota, Johansson, Åsa, Snitker, Søren, Cheng, Yu-Ching, Eriksson, Joel, Lim, Unhee, Aadahl, Mette, Adair, Linda S, Amin, Najaf, Balkau, Beverley, Auvinen, Juha, Beilby, John, Bergman, Richard N, Bergmann, Sven, Bertoni, Alain G, Blangero, John, Bonnefond, Amélie, Bonnycastle, Lori L, Borja, Judith B, Brage, Søren, Busonero, Fabio, Buyske, Steve, Campbell, Harry, Chines, Peter S, Collins, Francis S, Corre, Tanguy, Smith, George Davey, Delgado, Graciela E, Dueker, Nicole, Dörr, Marcus, Ebeling, Tapani, Eiriksdottir, Gudny, Esko, Tõnu, and Faul, Jessica D

Subjects
CHARGE Consortium, EPIC-InterAct Consortium, PAGE Consortium, Humans, Obesity, Genetic Predisposition to Disease, Body Mass Index, Waist-Hip Ratio, Exercise, Genotype, Female, Male, Adiposity, Waist Circumference, Genome-Wide Association Study, Epigenomics, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Genetics, Developmental Biology
Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

Published
2017

7. Genetics of Sedentariness

Author

Huppertz, Charlotte, de Geus, Eco J. C., van der Ploeg, Hidde P., Ahrens, Wolfgang, Series editor, Pigeot, Iris, Series editor, Leitzmann, Michael F., editor, Jochem, Carmen, editor, and Schmid, Daniela, editor

Published
2018
Full Text
View/download PDF

8. Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia—Data From a Multicenter Randomized-Controlled Study

Author

Roell, Lukas, primary, Keeser, Daniel, additional, Papazov, Boris, additional, Lembeck, Moritz, additional, Papazova, Irina, additional, Greska, David, additional, Muenz, Susanne, additional, Schneider-Axmann, Thomas, additional, Sykorova, Eliska B, additional, Thieme, Christina E, additional, Vogel, Bob O, additional, Mohnke, Sebastian, additional, Huppertz, Charlotte, additional, Roeh, Astrid, additional, Keller-Varady, Katriona, additional, Malchow, Berend, additional, Stoecklein, Sophia, additional, Ertl-Wagner, Birgit, additional, Henkel, Karsten, additional, Wolfarth, Bernd, additional, Tantchik, Wladimir, additional, Walter, Henrik, additional, Hirjak, Dusan, additional, Schmitt, Andrea, additional, Hasan, Alkomiet, additional, Meyer-Lindenberg, Andreas, additional, Falkai, Peter, additional, and Maurus, Isabel, additional

Published
2023
Full Text
View/download PDF

9. Step away from depression—results from a multicenter randomized clinical trial with a pedometer intervention during and after inpatient treatment of depression

Author

Große, Julia, primary, Huppertz, Charlotte, additional, Röh, Astrid, additional, Oertel, Viola, additional, Andresen, Sara, additional, Schade, Niklas, additional, Goerke-Arndt, Franziska, additional, Kastinger, Anna, additional, Schoofs, Nikola, additional, Thomann, Philipp Arthur, additional, Henkel, Karsten, additional, Malchow, Berend, additional, Plag, Jens, additional, Terziska, Aleksandra, additional, Brand, Ralf, additional, Helmig, Frank, additional, Schorb, Alexander, additional, Wedekind, Dirk, additional, Jockers-Scherübl, Maria, additional, Schneider, Frank, additional, Petzold, Moritz Bruno, additional, and Ströhle, Andreas, additional

Published
2023
Full Text
View/download PDF

10. Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia—Data From a Multicenter Randomized-Controlled Study.

Author

Roell, Lukas, Keeser, Daniel, Papazov, Boris, Lembeck, Moritz, Papazova, Irina, Greska, David, Muenz, Susanne, Schneider-Axmann, Thomas, Sykorova, Eliska B, Thieme, Christina E, Vogel, Bob O, Mohnke, Sebastian, Huppertz, Charlotte, Roeh, Astrid, Keller-Varady, Katriona, Malchow, Berend, Stoecklein, Sophia, Ertl-Wagner, Birgit, Henkel, Karsten, and Wolfarth, Bernd

Subjects
BRAIN physiology, BRAIN anatomy, RESEARCH, AEROBIC exercises, SCHIZOPHRENIA, TREATMENT effectiveness, RANDOMIZED controlled trials, RESEARCH funding, PSYCHOLOGICAL adaptation, LOGISTIC regression analysis
Abstract

Background and Hypothesis Aerobic exercise interventions in people with schizophrenia have been demonstrated to improve clinical outcomes, but findings regarding the underlying neural mechanisms are limited and mainly focus on the hippocampal formation. Therefore, we conducted a global exploratory analysis of structural and functional neural adaptations after exercise and explored their clinical implications. Study Design In this randomized controlled trial, structural and functional MRI data were available for 91 patients with schizophrenia who performed either aerobic exercise on a bicycle ergometer or underwent a flexibility, strengthening, and balance training as control group. We analyzed clinical and neuroimaging data before and after 6 months of regular exercise. Bayesian linear mixed models and Bayesian logistic regressions were calculated to evaluate effects of exercise on multiple neural outcomes and their potential clinical relevance. Study Results Our results indicated that aerobic exercise in people with schizophrenia led to structural and functional adaptations mainly within the default-mode network, the cortico-striato-pallido-thalamo-cortical loop, and the cerebello-thalamo-cortical pathway. We further observed that volume increases in the right posterior cingulate gyrus as a central node of the default-mode network were linked to improvements in disorder severity. Conclusions These exploratory findings suggest a positive impact of aerobic exercise on 3 cerebral networks that are involved in the pathophysiology of schizophrenia. Clinical Trials Registration The underlying study of this manuscript was registered in the International Clinical Trials Database, ClinicalTrials.gov (NCT number: NCT03466112, https://clinicaltrials.gov/ct2/show/NCT03466112?term=NCT03466112&draw=2&rank=1) and in the German Clinical Trials Register (DRKS-ID: DRKS00009804). [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Exercise as an Add-On Treatment in Individuals with Schizophrenia: Results from a Large Multicentre Randomized Controlled Trial

Author

Maurus, Isabel, primary, Roell, Lukas, additional, Lembeck, Moritz, additional, Papazova, Irina, additional, Greska, David, additional, Münz, Susanne, additional, Wagner, Elias, additional, Campana, Mattia, additional, Schwaiger, Rebecca, additional, Schneider-Axmann, Thomas, additional, Rosenberger, Kerstin, additional, Hellmich, Martin, additional, Sykorova, Eliska, additional, Cristina, Thieme E., additional, Vogel, Bob O., additional, Harder, Carolin, additional, Mohnke, Sebastian, additional, Huppertz, Charlotte, additional, Roeh, Astrid, additional, Keller-Varady, Katriona, additional, Malchow, Berend, additional, Walter, Henrik, additional, Wolfarth, Bernd, additional, Wölwer, Wolfgang, additional, Henkel, Karsten, additional, Hirajk, Dusan, additional, Schmitt, Andrea, additional, Hasan, Alkomiet, additional, Meyer-Lindenberg, Andreas, additional, and Falkai, Peter, additional

Published
2023
Full Text
View/download PDF

15. The young Netherlands twin register (YNTR): Longitudinal twin and family studies in over 70,000 children

Author

van Beijsterveldt, Catharine EM, Groen-Blokhuis, Maria, Hottenga, Jouke Jan, Franic, Sanja, Hudziak, James J, Lamb, Diane, Huppertz, Charlotte, de Zeeuw, Eveline, Nivard, Michel, Schutte, Nienke, Swagerman, Suzanne, Glasner, Tina, van Fulpen, Michelle, Brouwer, Cyrina, Stroet, Therese, Nowotny, Dustin, Ehli, Erik A, Davies, Gareth E, Scheet, Paul, Orlebeke, Jacob F, Kan, Kees-Jan, Smit, Dirk, Dolan, Conor V, Middeldorp, Christel M, de Geus, Eco JC, Bartels, Meike, and Boomsma, Dorret I

Published
2013

19. Associations of sleep with psychological problems and well-being in adolescence: causality or common genetic predispositions?

Author

Vermeulen, Marije C M, van der Heijden, Kristiaan B, Kocevska, Desana, Treur, Jorien L, Huppertz, Charlotte, van Beijsterveldt, Catharina E M, Boomsma, Dorret I, Swaab, Hanna, Van Someren, Eus J W, Bartels, Meike, Vermeulen, Marije C M, van der Heijden, Kristiaan B, Kocevska, Desana, Treur, Jorien L, Huppertz, Charlotte, van Beijsterveldt, Catharina E M, Boomsma, Dorret I, Swaab, Hanna, Van Someren, Eus J W, and Bartels, Meike

Abstract

BACKGROUND: Whereas short and problematic sleep are associated with psychological problems in adolescence, causality remains to be elucidated. This study therefore utilized the discordant monozygotic cotwin design and cross-lagged models to investigate how short and problematic sleep affect psychological functioning.METHODS: Adolescent twins (N = 12,803, 13-20 years, 42% male) completed questionnaires on sleep and psychological functioning repeatedly over a two-year interval. Monozygotic twin pairs were classified as concordant or discordant for sleep duration and trouble sleeping. Resulting subgroups were compared regarding internalizing problems, externalizing problems, and subjective well-being.RESULTS: Cross-sectional analyses indicated associations of worse psychological functioning with both short sleep and problematic sleep, and cross-lagged models indicate bidirectional associations. Longitudinal analyses showed that an increase in sleep problems experienced selectively by one individual of an identical twin pair was accompanied by an increase of 52% in internalizing problem scores and 25% in externalizing problem scores. These changes were significantly different from the within-subject changes in cotwins with unchanged sleep quality (respectively, 3% increase and 5% decrease). Psychological functioning did, however, not worsen with decreasing sleep duration.CONCLUSIONS: The findings suggest that sleep quality, rather than sleep duration, should be the primary target for prevention and intervention, with possible effect on psychological functioning in adolescents.

Published
2021

22. Associations of sleep with psychological problems and well‐being in adolescence: causality or common genetic predispositions?

Author

Vermeulen, Marije C.M., primary, Heijden, Kristiaan B., additional, Kocevska, Desana, additional, Treur, Jorien L., additional, Huppertz, Charlotte, additional, Beijsterveldt, Catharina E.M., additional, Boomsma, Dorret I., additional, Swaab, Hanna, additional, Someren, Eus J.W., additional, and Bartels, Meike, additional

Published
2020
Full Text
View/download PDF

24. Associations of sleep with psychological problems and well‐being in adolescence: causality or common genetic predispositions?

Author

Vermeulen, Marije C.M., Heijden, Kristiaan B., Kocevska, Desana, Treur, Jorien L., Huppertz, Charlotte, Beijsterveldt, Catharina E.M., Boomsma, Dorret I., Swaab, Hanna, Someren, Eus J.W., and Bartels, Meike

Subjects
CAUSALITY (Physics), GENETICS, QUESTIONNAIRES, SLEEP, SLEEP disorders, TEENAGERS' conduct of life, ADOLESCENT health, TWINS, WELL-being, BEHAVIOR disorders, CROSS-sectional method, ADOLESCENCE
Abstract

Background: Whereas short and problematic sleep are associated with psychological problems in adolescence, causality remains to be elucidated. This study therefore utilized the discordant monozygotic cotwin design and cross‐lagged models to investigate how short and problematic sleep affect psychological functioning. Methods: Adolescent twins (N = 12,803, 13–20 years, 42% male) completed questionnaires on sleep and psychological functioning repeatedly over a two‐year interval. Monozygotic twin pairs were classified as concordant or discordant for sleep duration and trouble sleeping. Resulting subgroups were compared regarding internalizing problems, externalizing problems, and subjective well‐being. Results: Cross‐sectional analyses indicated associations of worse psychological functioning with both short sleep and problematic sleep, and cross‐lagged models indicate bidirectional associations. Longitudinal analyses showed that an increase in sleep problems experienced selectively by one individual of an identical twin pair was accompanied by an increase of 52% in internalizing problem scores and 25% in externalizing problem scores. These changes were significantly different from the within‐subject changes in cotwins with unchanged sleep quality (respectively, 3% increase and 5% decrease). Psychological functioning did, however, not worsen with decreasing sleep duration. Conclusions: The findings suggest that sleep quality, rather than sleep duration, should be the primary target for prevention and intervention, with possible effect on psychological functioning in adolescents. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

25. Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Author

Graff, Mariaelisa, Scott, Robert A., Justice, Anne E., Young, Kristin L., Feitosa, Mary F., Barata, Llilda, Winkler, Thomas W., Chu, Audrey Y., Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L., den Hoed, Marcel, Ahluwalia, Tarunveer S., Qi, Qibin, Ngwa, Julius S., Renström, Frida, Quaye, Lydia, Eicher, John D., Hayes, James E., Cornelis, Marilyn, Kutalik, Zoltan, Lim, Elise, Luan, Jian’an, Huffman, Jennifer E., Zhang, Weihua, Zhao, Wei, Griffin, Paula J., Haller, Toomas, Ahmad, Shafqat, Marques-Vidal, Pedro M., Bien, Stephanie, Yengo, Loic, Teumer, Alexander, Smith, Albert Vernon, Kumari, Meena, Harder, Marie Neergaard, Justesen, Johanne Marie, Kleber, Marcus E., Hollensted, Mette, Lohman, Kurt, Rivera, Natalia V., Whitfield, John B., Zhao, Jing Hua, Stringham, Heather M., Lyytikäinen, Leo-Pekka, Huppertz, Charlotte, Willemsen, Gonneke, Peyrot, Wouter J., Graff, Mariaelisa, Scott, Robert A., Justice, Anne E., Young, Kristin L., Feitosa, Mary F., Barata, Llilda, Winkler, Thomas W., Chu, Audrey Y., Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L., den Hoed, Marcel, Ahluwalia, Tarunveer S., Qi, Qibin, Ngwa, Julius S., Renström, Frida, Quaye, Lydia, Eicher, John D., Hayes, James E., Cornelis, Marilyn, Kutalik, Zoltan, Lim, Elise, Luan, Jian’an, Huffman, Jennifer E., Zhang, Weihua, Zhao, Wei, Griffin, Paula J., Haller, Toomas, Ahmad, Shafqat, Marques-Vidal, Pedro M., Bien, Stephanie, Yengo, Loic, Teumer, Alexander, Smith, Albert Vernon, Kumari, Meena, Harder, Marie Neergaard, Justesen, Johanne Marie, Kleber, Marcus E., Hollensted, Mette, Lohman, Kurt, Rivera, Natalia V., Whitfield, John B., Zhao, Jing Hua, Stringham, Heather M., Lyytikäinen, Leo-Pekka, Huppertz, Charlotte, Willemsen, Gonneke, and Peyrot, Wouter J.

Published
2017
Full Text
View/download PDF

27. Smoking During Adolescence as a Risk Factor for Attention Problems

Author

Treur, Jorien L., primary, Willemsen, Gonneke, additional, Bartels, Meike, additional, Geels, Lot M., additional, van Beek, Jenny H.D.A., additional, Huppertz, Charlotte, additional, van Beijsterveldt, Catharina E.M., additional, Boomsma, Dorret I., additional, and Vink, Jacqueline M., additional

Published
2015
Full Text
View/download PDF

30. The Dopaminergic Reward System And Leisure Time Exercise Behavior

Author

Huppertz, Charlotte, primary, Bartels, Meike, additional, Groen-Blokhuis, Maria, additional, de Moor, Marleen, additional, van der Aa, Niels, additional, Abdellaoui, Abdel, additional, van Beijsterveldt, Catharina, additional, Ehli, Erik, additional, Hottenga, Jouke-Jan, additional, Willemsen, Gonneke, additional, Xiao, Xiangjun, additional, Scheet, Paul, additional, Davies, Gareth, additional, Boomsma, Dorret, additional, Hudziak, James, additional, and de Geus, Eco, additional

Published
2014
Full Text
View/download PDF

31. The Dopaminergic Reward System and Leisure Time Exercise Behavior: A Candidate Allele Study

Author

Huppertz, Charlotte, primary, Bartels, Meike, additional, Groen-Blokhuis, Maria M., additional, Dolan, Conor V., additional, de Moor, Marleen H. M., additional, Abdellaoui, Abdel, additional, van Beijsterveldt, Catharina E. M., additional, Ehli, Erik A., additional, Hottenga, Jouke-Jan, additional, Willemsen, Gonneke, additional, Xiao, Xiangjun, additional, Scheet, Paul, additional, Davies, Gareth E., additional, Boomsma, Dorret I., additional, Hudziak, James J., additional, and Geus, Eco J. C. de, additional

Published
2014
Full Text
View/download PDF

33. The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children

Author

van Beijsterveldt, Catharina E. M., primary, Groen-Blokhuis, Maria, additional, Hottenga, Jouke Jan, additional, Franić, Sanja, additional, Hudziak, James J., additional, Lamb, Diane, additional, Huppertz, Charlotte, additional, de Zeeuw, Eveline, additional, Nivard, Michel, additional, Schutte, Nienke, additional, Swagerman, Suzanne, additional, Glasner, Tina, additional, van Fulpen, Michelle, additional, Brouwer, Cyrina, additional, Stroet, Therese, additional, Nowotny, Dustin, additional, Ehli, Erik A., additional, Davies, Gareth E., additional, Scheet, Paul, additional, Orlebeke, Jacob F., additional, Kan, Kees-Jan, additional, Smit, Dirk, additional, Dolan, Conor V., additional, Middeldorp, Christel M., additional, de Geus, Eco J. C., additional, Bartels, Meike, additional, and Boomsma, Dorret I., additional

Published
2012
Full Text
View/download PDF

34. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Author

Graff, Mariaelisa, Scott, Robert A, Justice, Anne E, Young, Kristin L, Feitosa, Mary F, Barata, Llilda, Winkler, Thomas W, Chu, Audrey Y, Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L, Den Hoed, Marcel, Ahluwalia, Tarunveer S, Qi, Qibin, Ngwa, Julius S, Renström, Frida, Quaye, Lydia, Eicher, John D, Hayes, James E, Cornelis, Marilyn, Kutalik, Zoltan, Lim, Elise, Luan, Jian'an, Huffman, Jennifer E, Zhang, Weihua, Zhao, Wei, Griffin, Paula J, Haller, Toomas, Ahmad, Shafqat, Marques-Vidal, Pedro M, Bien, Stephanie, Yengo, Loic, Teumer, Alexander, Smith, Albert Vernon, Kumari, Meena, Harder, Marie Neergaard, Justesen, Johanne Marie, Kleber, Marcus E, Hollensted, Mette, Lohman, Kurt, Rivera, Natalia V, Whitfield, John B, Zhao, Jing Hua, Stringham, Heather M, Lyytikäinen, Leo-Pekka, Huppertz, Charlotte, Willemsen, Gonneke, Peyrot, Wouter J, Wu, Ying, Kristiansson, Kati, Demirkan, Ayse, Fornage, Myriam, Hassinen, Maija, Bielak, Lawrence F, Cadby, Gemma, Tanaka, Toshiko, Mägi, Reedik, Van Der Most, Peter J, Jackson, Anne U, Bragg-Gresham, Jennifer L, Vitart, Veronique, Marten, Jonathan, Navarro, Pau, Bellis, Claire, Pasko, Dorota, Johansson, Åsa, Snitker, Søren, Cheng, Yu-Ching, Eriksson, Joel, Lim, Unhee, Aadahl, Mette, Adair, Linda S, Amin, Najaf, Balkau, Beverley, Auvinen, Juha, Beilby, John, Bergman, Richard N, Bergmann, Sven, Bertoni, Alain G, Blangero, John, Bonnefond, Amélie, Bonnycastle, Lori L, Borja, Judith B, Brage, Søren, Busonero, Fabio, Buyske, Steve, Campbell, Harry, Chines, Peter S, Collins, Francis S, Corre, Tanguy, Smith, George Davey, Delgado, Graciela E, Dueker, Nicole, Dörr, Marcus, Ebeling, Tapani, Eiriksdottir, Gudny, Esko, Tõnu, Faul, Jessica D, Fu, Mao, Færch, Kristine, Gieger, Christian, Gläser, Sven, Gong, Jian, Gordon-Larsen, Penny, Grallert, Harald, Grammer, Tanja B, Grarup, Niels, Van Grootheest, Gerard, Harald, Kennet, Hastie, Nicholas D, Havulinna, Aki S, Hernandez, Dena, Hindorff, Lucia, Hocking, Lynne J, Holmens, Oddgeir L, Holzapfel, Christina, Hottenga, Jouke Jan, Huang, Jie, Huang, Tao, Hui, Jennie, Huth, Cornelia, Hutri-Kähönen, Nina, James, Alan L, Jansson, John-Olov, Jhun, Min A, Juonala, Markus, Kinnunen, Leena, Koistinen, Heikki A, Kolcic, Ivana, Komulainen, Pirjo, Kuusisto, Johanna, Kvaløy, Kirsti, Kähönen, Mika, Lakka, Timo A, Launer, Lenore J, Lehne, Benjamin, Lindgren, Cecilia M, Lorentzon, Mattias, Luben, Robert, Marre, Michel, Milaneschi, Yuri, Monda, Keri L, Montgomery, Grant W, De Moor, Marleen HM, Mulas, Antonella, Müller-Nurasyid, Martina, Musk, AW, Männikkö, Reija, Männistö, Satu, Narisu, Narisu, Nauck, Matthias, Nettleton, Jennifer A, Nolte, Ilja M, Oldehinkel, Albertine J, Olden, Matthias, Ong, Ken K, Padmanabhan, Sandosh, Paternoster, Lavinia, Perez, Jeremiah, Perola, Markus, Peters, Annette, Peters, Ulrike, Peyser, Patricia A, Prokopenko, Inga, Puolijoki, Hannu, Raitakari, Olli T, Rankinen, Tuomo, Rasmussen-Torvik, Laura J, Rawal, Rajesh, Ridker, Paul M, Rose, Lynda M, Rudan, Igor, Sarti, Cinzia, Sarzynski, Mark A, Savonen, Kai, Scott, William R, Sanna, Serena, Shuldiner, Alan R, Sidney, Steve, Silbernagel, Günther, Smith, Blair H, Smith, Jennifer A, Snieder, Harold, Stančáková, Alena, Sternfeld, Barbara, Swift, Amy J, Tammelin, Tuija, Tan, Sian-Tsung, Thorand, Barbara, Thuillier, Dorothée, Vandenput, Liesbeth, Vestergaard, Henrik, Van Vliet-Ostaptchouk, Jana V, Vohl, Marie-Claude, Völker, Uwe, Waeber, Gérard, Walker, Mark, Wild, Sarah, Wong, Andrew, Wright, Alan F, Zillikens, M Carola, Zubair, Niha, Haiman, Christopher A, Lemarchand, Loic, Gyllensten, Ulf, Ohlsson, Claes, Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, André G, Pérusse, Louis, Wilson, James F, Hayward, Caroline, Polasek, Ozren, Cucca, Francesco, Hveem, Kristian, Hartman, Catharina A, Tönjes, Anke, Bandinelli, Stefania, Palmer, Lyle J, Kardia, Sharon LR, Rauramaa, Rainer, Sørensen, Thorkild IA, Tuomilehto, Jaakko, Salomaa, Veikko, Penninx, Brenda WJH, De Geus, Eco JC, Boomsma, Dorret I, Lehtimäki, Terho, Mangino, Massimo, Laakso, Markku, Bouchard, Claude, Martin, Nicholas G, Kuh, Diana, Liu, Yongmei, Linneberg, Allan, März, Winfried, Strauch, Konstantin, Kivimäki, Mika, Harris, Tamara B, Gudnason, Vilmundur, Völzke, Henry, Qi, Lu, Järvelin, Marjo-Riitta, Chambers, John C, Kooner, Jaspal S, Froguel, Philippe, Kooperberg, Charles, Vollenweider, Peter, Hallmans, Göran, Hansen, Torben, Pedersen, Oluf, Metspalu, Andres, Wareham, Nicholas J, Langenberg, Claudia, Weir, David R, Porteous, David J, Boerwinkle, Eric, Chasman, Daniel I, CHARGE Consortium, EPIC-InterAct Consortium, PAGE Consortium, Abecasis, Gonçalo R, Barroso, Inês, McCarthy, Mark I, Frayling, Timothy M, O'Connell, Jeffrey R, Van Duijn, Cornelia M, Boehnke, Michael, Heid, Iris M, Mohlke, Karen L, Strachan, David P, Fox, Caroline S, Liu, Ching-Ti, Hirschhorn, Joel N, Klein, Robert J, Johnson, Andrew D, Borecki, Ingrid B, Franks, Paul W, North, Kari E, Cupples, L Adrienne, Loos, Ruth JF, and Kilpeläinen, Tuomas O

Subjects
Epigenomics, Male, Genotype, Waist-Hip Ratio, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, 3. Good health, Body Mass Index, Humans, Female, Genetic Predisposition to Disease, Obesity, Waist Circumference, Exercise, Adiposity, Genome-Wide Association Study
Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

35. Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

Author

Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renström F, Quaye L, Eicher JD, Hayes JE, Cornelis M, Kutalik Z, Lim E, Luan J, Huffman JE, Zhang W, Zhao W, Griffin PJ, Haller T, Ahmad S, Marques-Vidal PM, Bien S, Yengo L, Teumer A, Smith AV, Kumari M, Harder MN, Justesen JM, Kleber ME, Hollensted M, Lohman K, Rivera NV, Whitfield JB, Zhao JH, Stringham HM, Lyytikäinen LP, Huppertz C, Willemsen G, Peyrot WJ, Wu Y, Kristiansson K, Demirkan A, Fornage M, Hassinen M, Bielak LF, Cadby G, Tanaka T, Mägi R, van der Most PJ, Jackson AU, Bragg-Gresham JL, Vitart V, Marten J, Navarro P, Bellis C, Pasko D, Johansson Å, Snitker S, Cheng YC, Eriksson J, Lim U, Aadahl M, Adair LS, Amin N, Balkau B, Auvinen J, Beilby J, Bergman RN, Bergmann S, Bertoni AG, Blangero J, Bonnefond A, Bonnycastle LL, Borja JB, Brage S, Busonero F, Buyske S, Campbell H, Chines PS, Collins FS, Corre T, Smith GD, Delgado GE, Dueker N, Dörr M, Ebeling T, Eiriksdottir G, Esko T, Faul JD, Fu M, Færch K, Gieger C, Gläser S, Gong J, Gordon-Larsen P, Grallert H, Grammer TB, Grarup N, van Grootheest G, Harald K, Hastie ND, Havulinna AS, Hernandez D, Hindorff L, Hocking LJ, Holmens OL, Holzapfel C, Hottenga JJ, Huang J, Huang T, Hui J, Huth C, Hutri-Kähönen N, James AL, Jansson JO, Jhun MA, Juonala M, Kinnunen L, Koistinen HA, Kolcic I, Komulainen P, Kuusisto J, Kvaløy K, Kähönen M, Lakka TA, Launer LJ, Lehne B, Lindgren CM, Lorentzon M, Luben R, Marre M, Milaneschi Y, Monda KL, Montgomery GW, De Moor MHM, Mulas A, Müller-Nurasyid M, Musk AW, Männikkö R, Männistö S, Narisu N, Nauck M, Nettleton JA, Nolte IM, Oldehinkel AJ, Olden M, Ong KK, Padmanabhan S, Paternoster L, Perez J, Perola M, Peters A, Peters U, Peyser PA, Prokopenko I, Puolijoki H, Raitakari OT, Rankinen T, Rasmussen-Torvik LJ, Rawal R, Ridker PM, Rose LM, Rudan I, Sarti C, Sarzynski MA, Savonen K, Scott WR, Sanna S, Shuldiner AR, Sidney S, Silbernagel G, Smith BH, Smith JA, Snieder H, Stančáková A, Sternfeld B, Swift AJ, Tammelin T, Tan ST, Thorand B, Thuillier D, Vandenput L, Vestergaard H, van Vliet-Ostaptchouk JV, Vohl MC, Völker U, Waeber G, Walker M, Wild S, Wong A, Wright AF, Zillikens MC, Zubair N, Haiman CA, Lemarchand L, Gyllensten U, Ohlsson C, Hofman A, Rivadeneira F, Uitterlinden AG, Pérusse L, Wilson JF, Hayward C, Polasek O, Cucca F, Hveem K, Hartman CA, Tönjes A, Bandinelli S, Palmer LJ, Kardia SLR, Rauramaa R, Sørensen TIA, Tuomilehto J, Salomaa V, Penninx BWJH, de Geus EJC, Boomsma DI, Lehtimäki T, Mangino M, Laakso M, Bouchard C, Martin NG, Kuh D, Liu Y, Linneberg A, März W, Strauch K, Kivimäki M, Harris TB, Gudnason V, Völzke H, Qi L, Järvelin MR, Chambers JC, Kooner JS, Froguel P, Kooperberg C, Vollenweider P, Hallmans G, Hansen T, Pedersen O, Metspalu A, Wareham NJ, Langenberg C, Weir DR, Porteous DJ, Boerwinkle E, Chasman DI, Abecasis GR, Barroso I, McCarthy MI, Frayling TM, O'Connell JR, van Duijn CM, Boehnke M, Heid IM, Mohlke KL, Strachan DP, Fox CS, Liu CT, Hirschhorn JN, Klein RJ, Johnson AD, Borecki IB, Franks PW, North KE, Cupples LA, Loos RJF, and Kilpeläinen TO

Abstract

[This corrects the article DOI: 10.1371/journal.pgen.1006528.].

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results