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1. Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting

Author

Correale, Jorge, Caride, Alejandro, Deri, Norma H., Ballario, Carlos, Broadley, Simon, Kneebone, Chris, Barnett, Michael, Pollard, John, Hodgkinson, Suzanne, Kermode, Allan, Macdonell, Richard, King, John, Butzkueven, Helmut, Lechner-Scott, Jeannette, Saines, Noel, Slee, Mark, Plummer, Chris, Willekens, Barbara, Vanopdenbosch, Ludo, Belachew, Shibeshih, Phan-Ba, Rémy, Delvaux, Valérie, Bissay, Veronique, Debruyne, Jan, Decoo, Danny, Crols, Roeland, Symons, Anoek, Nagels, Guy, Van Pesch, Vincent, Sindic, Christian, Dubois, Benedicte, Medaer, Robert, D'Hooghe, Marie, Guillaume, Daniel, De Smet, Eric, Seeldrayers, Pierrette, Lysandropoulos, Andreas, Vokaer, Mathieu, Geens, Karine, Willems, Christina, Denayer, Pierre, Bureau, Michel, Retif, Cecile, Dupuis, Michel, Bouquiaux, Olivier, Vanderdonckt, Patrick, van Landegem, William, Caekebeke, Jo, Van Ingelghem, Erwin, Peeters, Katelijne, Gerard, Pascale, de Noordhout, Alain Maertens, Desfontaines, Philippe, Urbain, Etienne, Declercq, Inge, Van Wijmeersch, Bart, Vanroose, Erwin, Wibail, Alain, Barthomolé, Emmanuel, Ursell, Melanie, Sweet, Margaret Elizabeth, Howse, David, Jichici, Draga, Shawush, Melad, Namaka, Mike, Traboulsee, Anthony, Hashimoto, Stan, Lo, Raymond, Marchetti, Paul, Lapierre, Yves, Jacques, Francois, MacLean, Gregg, Bhan, Virender, Duquette, Pierre, Stewart, Bradley, Paulseth, John, Kremenchutzky, Marcelo, Vorobeychik, Galina, O'Connor, Paul, Grand'Maison, François, Havrdova, Eva, Meluzinová, Eva, Valis, Martin, Talab, Radomír, Stourac, Pavel, Zapletalová, Olga, Dufek, Michal, Sládková, Vladimíra, Novotna, Alena, Vancurová, Romana, Lhotaková, Libuse, Fiedler, Jiri, Vachova, Marta, Dolezil, David, Stetkarova, Ivana, Rehankova, Adela, Psenica, Petr, Ulehlova, Veronika, Feketova, Sona, Skoda, Ondrej, Färkkilä, Markus, Taneli, Sarasoja, Koivisto, Keijo, Seppä, Juha Matti, Airas, Laura, Elovaara, Irina, Hartikainen, Päivi, Pirttila, Tuula, Louchart, Pierre, Ille, Olivier, Thenint, Jean philippe, Godet, Etienne, Vioud, Marcel Maillet, Colamarino, Renato, Gugenheim, Michel, Grimaud, Jerome, Kopf, Audrey, Billy, Christophe, Huttin, Bernard, Borsotti, Jean paul, Devos, Philippe, Kendjuo, Jean bertin N, Verier, Albert, Chapuis, Stephane, Daluzeau, Nathalie, Angibaud, Gilles, Uriot, Marie-Sylvie Artaud, Ziegler, François, Sellal, François, Moulignier, Antoine, Lavenu, Isabelle, Ismail, Samir, Devy, Richard, Suceveanu, Manuel, Wagner, Marc, Marcel, Sebastien, Derouiche, Faycal, Mostoufizadehghalamfarsa, Sohrab, Delalande, Sophie, Ruggieri, Irene, Van Nieuwenhuyse, Catherine Bossu, Nifle, Chantal, Ondze, Basile, Vasilescu, Carmen Gurau, Vongsouthi, Cyrille, Coustans, Marc, Anne, Olivier, Amevigbe, Josephine, Servan, Jerome, Merienne, Marc, Eck, Philippe, Berroir, Stephane, Busson, Philippe, Barroso, Bruno, Larrieu, Jean-Marc, Giendaj, Catherine Louvet, Malkoun, Imad, Hautecoeur, Patrick, Kwiatkowski, Arnaud, Pouliquen, Andre, Garrigues, Guillaume, Delerue, Olivier, Giraud, Pierric, Gere, Julien, Vaunaize, Jean, Dereeper, Olivier, Seiller, Nicolas, Alsassa, Roger, Vlaicu, Mihaela, Neuville, Veronique, Faucheux, Jean Marc, Bernady, Patricia, Fanjaud, Guy, Viallet, François, Schroeter, Michael, Schlemilch-Paschen, Sylke, Lange, Thomas, Bohr, Kin-Arno, Jendroska, Klaus, Rehkopf, Elisabeth, Bergmann, Arnfin, Kleinschnitz, Christoph, Postert, Thomas, Scholz, Peter, Mauz, Uwe, Stratmann, Hubert, Siefjediers, Veneta, Prantl, Martin, Gehring, Klaus, Zellner, Ruth, Junge, Kathrin, Zellner, Anton, Bacay, Valerina, Schlegel, Eugen, Polzer, Udo, Strauss, Erik, Link, Andreas, Stenzel, Christoph, Freidel, Matthias, Drews, Joachim, Neudert, Christian, Schmitz, Frank, Jaeger, Joachim, Masri, Said, Heuberger, Wolfgang, Trausch, Beate, Ruhnke, Oliver, Scarel, Serena, Bach, Kathlen, Ernst, Michael, Landefeld, Harald, Richter, Nils, Schmidt, Stephan, Krause, Michaela, Dressel, Alezander, Ruth, Roland, Anvari, Kerstin, Gossling, Jens, Schenk, Christoph, Tiedge, Oliver, Bode, Lutz, Eder, Hans-Thomas, Pfeffer, Oliver, Krug, Reinhard, Lassek, Christoph, Fleischer, Eberhard, Meuth, Sven, Klotz, Luisa Hildegard, Peglau, Ines, Kukowski, Borries, Herting, Birgit, Guthke, Kersten, Schierenbeck, Jurgen, Brockmeier, Bernd, Albrecht, Holger, Wuttke, Matthias, Augspach-Hofmann, Regine, Gunther, Stefan, Redbrake, Martin, Franke, Christian, Buchner, Klaus, Gratz, Thomas, Horn, Rolf, Doemges, Frank, Schreiber, Martin, Brosch, Thomas, Horn, Markus, Kittlitz, Matthias, Vulturius, Gabriele, Hinse, Paul, Malessa, Rolf, Wiehler, Stephan, Katsarava, Zaza, Kastrup, Oliver, Kausch, Ulrich, Gullekes, Martin, Fickinger, Markus, Wenzel, Wilhelm, Botefur, Ingolf C., Reifschneider, Gerd, Rauer, Sebastian, Lang, Michael, Harms, Lutz, Eckhardt, Ulrich, Cursiefen, Simone, Linker, Ralf, Angstwurm, Klemens, Haas, Judith, Schuetze, Ivo, Rohm, Eva, Stienker-Fisse, H., Sailer, Michael, Bohringer, Johannes, Maurer, Mathias, Bause, Eberhard, Wersching, Ronald, Dachsel, Reinhardt, Domke, Sylke, Hoffman, Frank, Tackenberg, Bjorn, Roch, Kerstin, Ziebold, Uwe, Kallmann, Boris, Buehler, Bernhard, Faiss, Judith, Faiss, Juergen, Schimrigk, Sebastian, Menges, Christian, Knop, Karl Christian, Koehler, Wolfgang, Siever, Arno, Bufler, Johannes, Gramsl, Georg, Kuhnler, Benedicta, Maschke, Matthias, Stogbauer, Florian, Staude, Lisa, Bethke, Florian, Bitsch, Andreas, Harmjanz, Arndt D., Windsheimer, Jorg, Kieseier, Bernd C., Berkenfeld, Ralf, Tumani, Hayrettin, Kirsch, Michael, Wildemann, Brigitte, Daniels, Regina, Gottwald, Klaus, Elias, Wolfgang-Gerhard, Hoffmann, Olaf, Schwab, Matthias, Pilz, Christopher, Klostermann, Fabian, Hellwig, Kerstin, Berthele, Achim, Bayas, Antonios, Molitor, Daniel, Grothe, Christoph, Wagner, Bert, Karageorgiou, Klimentini, Mitsikostas, Dimosthenis, Kodounis, Antonios, Plaitakis, Andreas, Papadimitriou, Alexandros, Grigoriadis, Nikolaos, Vlaikidis, Nikolaos, Koutlas, Evaggelos, Kyritsis, Athanassios, Papathanassopoulos, Panagiotis, Makris, Nikolaos, Tavernarakis, Antonios, Scarpini, Elio, Montanari, Enrico, Marrosu, Maria Giovanna, Trojano, Maria, Amato, Maria Pia, Rottoli, Mariarosa, Lugaresi, Alessandra, Florio, Ciro, Gasperini, Claudio, Grimaldi, Luigi, Millefiorini, Enrico, Koudriavtseva, Tatiana, Perla, Franco, Mantegazza, Renato, Bertolotto, Antonio, Ghezzi, Angelo, Aguilar, Sandra Quinones, Eisenberg, Eli Skromne, Lopez, Leondardo Llamas, Estudillo, Rocio Marquez, Schrijver, H.M., Wittebol, M.C., Baart, J.C., van Golde, A.E.L., Hengstman, G.J.D., Pop, P.H.M., Bos (Geldrop), M., Medaer, R., Schyns-Soeterboek, Angelique, van der Zwart, A., van Diepen, A.J.H., Verheul, G.A.M., Verhagen, W.I.M., Bos (Helmond), M., Witjes, R.J.G.M., Sinnige, L.G.F., van Munster, E.Th.L., Sanders, E.A.C.M., van Dijl, Ron, Hupperts, R.M.M., Frequin, S.T.F.M., Visser, L.H., Henselmans, J.M.L., Moll, J.W.B., Midgard, Rune, Myhr, Kjell Morten, Edland, Astrid, Telstad, Wenche, Hognestad, Tone, Lund, Christian, Hovdal, Harald, Kamaljit, Kaur, Schepel, Jan, Hogenesch, Roelfien Ida, Schüler, Stephan, Odeh, Francis, Alstadhaug, Karl B., Korsgaard, Olav, Farbu, Elisabeth, Ingvaldsen, Teis Barclay, Soares (SCO), Diana, Rente, José, Guerra, José Manuel Costa, Morganho, Armando, Leitão, António, de Sá, João, Sá, Maria José, Marques, Pinto, Veloso, Mário, Baptista, Miguel Viana, Szilasiová, Jarmila, Copikova-Cudrakova, Daniela, Prochazkova, Lubica, Klimová, Eleonóra, Donath, Vladimir, Brozman, Miroslav, Ramo, Cristina, Ruiz, Domingo Pérez, Hernández, Carmen Calles, Sola, María Eugenia Marzo, Moro, Roberto Suarez, Vidal, Jose Antonio, Rodríguez, Ana Belén Caminero, Ozaeta, Gisela Martin, Nadal, Jordi Batlle, Esquide, Amaya Alvarez de Arcaya, Urtaza, Javier Olascoaga, Martínez-Yélamos, Sergio, Arbizu, Txomin, Torrenta, Lluis Ramio i, Boggild, Mike, Wilson, Martin, Al-Araji, Adnan, Nicholas, Richard, Harrower, Timothy, Redmond, Ian, Wolf, Tilo, Osei-Bonsu, Michael, Mazibrada, Gordon, Rog, David, Cottrell, David, Constantinescu, Cris, Gray, Orla, Belhag, Mohamed, Shehu, Abdullah, Rashid, Waqar, Duddy, Martin, Kappos, Ludwig, Wiendl, Heinz, Spelman, Tim, Pellegrini, Fabio, Chen, Yi, Dong, Qunming, and Koendgen, Harold

Published
2018
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6. Predicting long-term sustained disability progression in multiple sclerosis.

Author

Van Wijmeersch B., Malpas C., Hupperts R.M.M., Alroughani R., Boz C., Shaygannejad V., Van Pesch V., Kappos L., Lechner-Scott J., Bergamaschi R., Turkoglu R., Solaro C., Ramo-Tello C., Iuliano G., Granella F., Spitaleri D.L.A., Bolanos R.F., Slee M., McCombe P., Prevost J., Ampapa R., Ozakbas S., Sanchez-Menoyo J.L., Soysal A., Vucic O., Petersen T., Verheul F., Butler E., Hodgkinson S., Sidhom Y., Gouider R., Cristiano E., Urtaza F.J.O., Saladino M.L., Barnett M., Deri N., Moore F., Rozsa C., Yamout B., Skibina O., Gray O., Campbell J., Sempere A., Singhal B., Fragoso Y., Shaw C., Kermode A., Petkovska-Boskova T., Taylor B., Simo M., Vella N., Shuey N., Alkhaboori J., Al-Harbi T., Macdonell R., Dominguez J.A., Kister I., Csepany T., Vrech C., Kovacs K., Sirbu C.A., Hughes S., Sormani M.P., Butzkueven H., Kalincik T., Sharmin S., Bovis F., Horakova D., Havrdova E., Ayuso G.I., Eichau S., Trojano M., Prat A., Girard M., Duquette P., Onofrj M., Lugaresi A., Grand'Maison F., Grammond P., Sola P., Ferraro D., Terzi M., Van Wijmeersch B., Malpas C., Hupperts R.M.M., Alroughani R., Boz C., Shaygannejad V., Van Pesch V., Kappos L., Lechner-Scott J., Bergamaschi R., Turkoglu R., Solaro C., Ramo-Tello C., Iuliano G., Granella F., Spitaleri D.L.A., Bolanos R.F., Slee M., McCombe P., Prevost J., Ampapa R., Ozakbas S., Sanchez-Menoyo J.L., Soysal A., Vucic O., Petersen T., Verheul F., Butler E., Hodgkinson S., Sidhom Y., Gouider R., Cristiano E., Urtaza F.J.O., Saladino M.L., Barnett M., Deri N., Moore F., Rozsa C., Yamout B., Skibina O., Gray O., Campbell J., Sempere A., Singhal B., Fragoso Y., Shaw C., Kermode A., Petkovska-Boskova T., Taylor B., Simo M., Vella N., Shuey N., Alkhaboori J., Al-Harbi T., Macdonell R., Dominguez J.A., Kister I., Csepany T., Vrech C., Kovacs K., Sirbu C.A., Hughes S., Sormani M.P., Butzkueven H., Kalincik T., Sharmin S., Bovis F., Horakova D., Havrdova E., Ayuso G.I., Eichau S., Trojano M., Prat A., Girard M., Duquette P., Onofrj M., Lugaresi A., Grand'Maison F., Grammond P., Sola P., Ferraro D., and Terzi M.

Abstract

Objective: Using global MSBase registry, this study establishes 6-month confirmed disability progression events as indicators of long-term disability worsening suitable for use in randomized clinical trials in multiple sclerosis (MS). Background(s): Randomized clinical trials evaluate short-term treatment effect on disability in the form of 3-6-month confirmed disability progression, but whether these translate into long-term disability outcomes is unknown. Design/Methods: A Cox proportional hazards model identified associations between patients' demographic and clinical characteristics and the probability of recovery from disability progression events. The coefficients from this model were used to calculate a sustained progression score, which was evaluated in a validation cohort and applied to a trial cohort. Result(s): 902 patients (development cohort), patient characteristics at the time of progression associated with lower probability of subsequent improvement were age (hazard ratio (HR)=0.98), primary progressive (HR=0.37) and progressive-relapsing (HR=0.36) MS, expanded disability status scale score >=6 (HR=0.71) and its change from baseline (HR=0.67), number of affected functional system scores (HR=0.92) and pyramidal (HR=0.79) functional system score (p<0.05). The strength of the association with pyramidal score decreased with time (HR=1.01). A relapse within previous month (HR=1.46) and worsening in sensory functional system score (HR=1.17) were associated with higher probability of improvement after progression. The sustained progression score (range 0.39-4.79) in the validation cohort with 1,271 progression events, estimated a 53% lower chance of improvement for each unit increase in the score (HR=0.47). The proportions of progression events sustained at 5 years stratified by the score were 1: 68%, 2: 79%, 3: 94%, 4: 100%. The progression scores were then applied to the CLARITY trial data. Conclusion(s): Estimate of the probability of disability progress

Published
2020

8. Predicting Long-Term Sustained Disability Progression in Multiple Sclerosis (2002)

Author

Sharmin, Sifat, primary, Bovis, Francesca, additional, Malpas, Charles, additional, Horakova, Dana, additional, Havrdova, Eva, additional, Ayuso, Guillermo Izquierdo, additional, Eichau, Sara, additional, Trojano, Maria, additional, Prat, Alexandre, additional, Girard, Marc, additional, Duquette, Pierre, additional, Onofrj, Marco, additional, Lugaresi, Alessandra, additional, Grand’Maison, Francois, additional, Grammond, Pierre, additional, Sola, Patrizia, additional, Ferraro, Diana, additional, Terzi, Murat, additional, Hupperts, R.M.M., additional, Alroughani, Raed, additional, Boz, Cavit, additional, Shaygannejad, Vijay, additional, Van Pesch, Vincent, additional, Kappos, Ludwig, additional, Lechner-Scott, Jeannette, additional, Bergamaschi, Roberto, additional, Turkoglu, Recai, additional, Solaro, Claudio, additional, Ramo-Tello, Cristina, additional, Iuliano, Gerardo, additional, Granella, Franco, additional, Van Wijmeersch, Bart, additional, Spitaleri, Daniele Litterio A., additional, Bolanos, Ricardo Fernandez, additional, Slee, Mark, additional, McCombe, Pamela, additional, Prevost, Julie, additional, Ampapa, Radek, additional, Ozakbas, Serkan, additional, Sanchez-Menoyo, Jose Luis, additional, Soysal, Aysun, additional, Vucic, Ostoja (Steve), additional, Petersen, Thor, additional, Verheul, Freek, additional, Butler, Ernest, additional, Hodgkinson, Suzanne, additional, Sidhom, Youssef, additional, Gouider, Riadh, additional, Cristiano, Edgardo, additional, Urtaza, Francisco Javier Olascoaga, additional, Saladino, Maria Laura, additional, Barnett, Michael, additional, Deri, Norma, additional, Moore, Fraser, additional, Rozsa, Csilla, additional, Yamout, Bassem, additional, Skibina, Olga, additional, Gray, Orla, additional, Campbell, Jamie, additional, Sempere, Angel, additional, Singhal, Bhim, additional, Fragoso, Yara, additional, Shaw, Cameron, additional, Kermode, Allan, additional, Petkovska-Boskova, Tatjana, additional, Taylor, Bruce, additional, Simo, Magdolna, additional, Vella, Norbert, additional, Shuey, Neil, additional, Alkhaboori, Jabir, additional, Al-Harbi, Talal, additional, Macdonell, Richard, additional, Dominguez, Jose Andres, additional, Kister, Ilya, additional, Csepany, Tunde, additional, Vrech, Carlos, additional, Kovacs, Krisztina, additional, Sirbu, Carmen Adella, additional, Hughes, Stella, additional, Sormani, Maria Pia, additional, Butzkueven, Helmut, additional, and Kalincik, Tomas, additional

Published
2020
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9. Lower Long-Term Disability with Early Start of High-Efficacy Therapies in Multiple Sclerosis (1182)

Author

He, Anna, primary, Merkel, Bernd, additional, Brown, J William, additional, Ryerson, Lana Zhovtis, additional, Kister, Ilya, additional, Malpas, Charles, additional, Horakova, Dana, additional, Havrdova, Eva, additional, Ayuso, Guillermo Izquierdo, additional, Madueno, Sara Eichau, additional, Lugaresi, Alessandra, additional, Hupperts, R.M.M., additional, Sola, Patrizia, additional, Ferraro, Diana, additional, Butzkueven, Helmut, additional, Grand-Maison, Francois, additional, Prat, Alexandre, additional, Girard, Marc, additional, Duquette, Pierre, additional, Petersen, Thor, additional, Grammond, Pierre, additional, Granella, Franco, additional, Van Pesch, Vincent, additional, Bergamaschi, Roberto, additional, and Kalincik, Tomas, additional

Published
2020
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10. Immunotherapies Improve Long-Term Disability Outcomes in Relapsing-Remitting Multiple Sclerosis (639)

Author

Kalincik, Tomas, primary, Diouf, Ibrahima, additional, Malpas, Charles, additional, Horakova, Dana, additional, Havrdova, Eva, additional, Trojano, Maria, additional, Ayuso, Guillermo Izquierdo, additional, Eichau, Sara, additional, Onofrj, Marco, additional, Lugaresi, Alessandra, additional, Prat, Alexandre, additional, Girard, Marc, additional, Duquette, Pierre, additional, Grammond, Pierre, additional, Grand’Maison, Francois, additional, Sola, Patrizia, additional, Ferraro, Diana, additional, Shaygannejad, Vahid, additional, Alroughani, Raed, additional, Hupperts, R.M.M., additional, Terzi, Murat, additional, Boz, Cavit, additional, Lechner-Scott, Jeannette, additional, Cartechini, Elisabetta, additional, Van Pesch, Vincent, additional, Iuliano, Gerardo, additional, Granella, Franco, additional, Bergamaschi, Roberto, additional, Bolanos, Ricardo Fernandez, additional, Spitaleri, Daniele Litterio A., additional, Slee, Mark, additional, Vucic, Ostoja (Steve), additional, Ampapa, Radek, additional, McCombe, Pamela, additional, Ramo-Tello, Cristina, additional, Petersen, Thor, additional, Verheul, Freek, additional, Prevost, Julie, additional, Urtaza, Francisco Javier Olascoaga, additional, Cristiano, Edgardo, additional, and Butzkueven, Helmut, additional

Published
2020
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11. Caregiver strain among life partners of individuals with relapsing-remitting multiple sclerosis

Author

Hiele, van der K., Gorp, D.A.M. van, Heerings, M., Jongen, P.J., Lieshout, I., Klink, van der J.J.L., Reneman, M.F., Arnoldus, E.P.J., Beenakker, E.A.C., Bos, H.M., Eijk, van J.J.J., Fermont, J., Frequin, S.T.F.M., Geel, van B., Hengstman, G.J.D., Hoitsma, E., Hupperts, R.M.M., Moll, J.W.B., Mostert, J.P., Pop, P., Verhagen, W., Gans, de K., Zemel, D., Middelkoop, H.A.M., Visser, L. H., A just and caring society, University of Humanistic Studies, and Care Ethics

Published
2019

13. Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting

Author

Trojano, Maria, primary, Butzkueven, Helmut, additional, Kappos, Ludwig, additional, Wiendl, Heinz, additional, Spelman, Tim, additional, Pellegrini, Fabio, additional, Chen, Yi, additional, Dong, Qunming, additional, Koendgen, Harold, additional, Belachew, Shibeshih, additional, Correale, Jorge, additional, Caride, Alejandro, additional, Deri, Norma H., additional, Ballario, Carlos, additional, Broadley, Simon, additional, Kneebone, Chris, additional, Barnett, Michael, additional, Pollard, John, additional, Hodgkinson, Suzanne, additional, Kermode, Allan, additional, Macdonell, Richard, additional, King, John, additional, Lechner-Scott, Jeannette, additional, Saines, Noel, additional, Slee, Mark, additional, Plummer, Chris, additional, Willekens, Barbara, additional, Vanopdenbosch, Ludo, additional, Phan-Ba, Rémy, additional, Delvaux, Valérie, additional, Bissay, Veronique, additional, Debruyne, Jan, additional, Decoo, Danny, additional, Crols, Roeland, additional, Symons, Anoek, additional, Nagels, Guy, additional, Van Pesch, Vincent, additional, Sindic, Christian, additional, Dubois, Benedicte, additional, Medaer, Robert, additional, D'Hooghe, Marie, additional, Guillaume, Daniel, additional, De Smet, Eric, additional, Seeldrayers, Pierrette, additional, Lysandropoulos, Andreas, additional, Vokaer, Mathieu, additional, Geens, Karine, additional, Willems, Christina, additional, Denayer, Pierre, additional, Bureau, Michel, additional, Retif, Cecile, additional, Dupuis, Michel, additional, Bouquiaux, Olivier, additional, Vanderdonckt, Patrick, additional, van Landegem, William, additional, Caekebeke, Jo, additional, Van Ingelghem, Erwin, additional, Peeters, Katelijne, additional, Gerard, Pascale, additional, de Noordhout, Alain Maertens, additional, Desfontaines, Philippe, additional, Urbain, Etienne, additional, Declercq, Inge, additional, Van Wijmeersch, Bart, additional, Vanroose, Erwin, additional, Wibail, Alain, additional, Barthomolé, Emmanuel, additional, Ursell, Melanie, additional, Sweet, Margaret Elizabeth, additional, Howse, David, additional, Jichici, Draga, additional, Shawush, Melad, additional, Namaka, Mike, additional, Traboulsee, Anthony, additional, Hashimoto, Stan, additional, Lo, Raymond, additional, Marchetti, Paul, additional, Lapierre, Yves, additional, Jacques, Francois, additional, MacLean, Gregg, additional, Bhan, Virender, additional, Duquette, Pierre, additional, Stewart, Bradley, additional, Paulseth, John, additional, Kremenchutzky, Marcelo, additional, Vorobeychik, Galina, additional, O'Connor, Paul, additional, Grand'Maison, François, additional, Havrdova, Eva, additional, Meluzinová, Eva, additional, Valis, Martin, additional, Talab, Radomír, additional, Stourac, Pavel, additional, Zapletalová, Olga, additional, Dufek, Michal, additional, Sládková, Vladimíra, additional, Novotna, Alena, additional, Vancurová, Romana, additional, Lhotaková, Libuse, additional, Fiedler, Jiri, additional, Vachova, Marta, additional, Dolezil, David, additional, Stetkarova, Ivana, additional, Rehankova, Adela, additional, Psenica, Petr, additional, Ulehlova, Veronika, additional, Feketova, Sona, additional, Skoda, Ondrej, additional, Färkkilä, Markus, additional, Taneli, Sarasoja, additional, Koivisto, Keijo, additional, Seppä, Juha Matti, additional, Airas, Laura, additional, Elovaara, Irina, additional, Hartikainen, Päivi, additional, Pirttila, Tuula, additional, Louchart, Pierre, additional, Ille, Olivier, additional, Thenint, Jean philippe, additional, Godet, Etienne, additional, Vioud, Marcel Maillet, additional, Colamarino, Renato, additional, Gugenheim, Michel, additional, Grimaud, Jerome, additional, Kopf, Audrey, additional, Billy, Christophe, additional, Huttin, Bernard, additional, Borsotti, Jean paul, additional, Devos, Philippe, additional, Kendjuo, Jean bertin N, additional, Verier, Albert, additional, Chapuis, Stephane, additional, Daluzeau, Nathalie, additional, Angibaud, Gilles, additional, Uriot, Marie-Sylvie Artaud, additional, Ziegler, François, additional, Sellal, François, additional, Moulignier, Antoine, additional, Lavenu, Isabelle, additional, Ismail, Samir, additional, Devy, Richard, additional, Suceveanu, Manuel, additional, Wagner, Marc, additional, Marcel, Sebastien, additional, Derouiche, Faycal, additional, Mostoufizadehghalamfarsa, Sohrab, additional, Delalande, Sophie, additional, Ruggieri, Irene, additional, Van Nieuwenhuyse, Catherine Bossu, additional, Nifle, Chantal, additional, Ondze, Basile, additional, Vasilescu, Carmen Gurau, additional, Vongsouthi, Cyrille, additional, Coustans, Marc, additional, Anne, Olivier, additional, Amevigbe, Josephine, additional, Servan, Jerome, additional, Merienne, Marc, additional, Eck, Philippe, additional, Berroir, Stephane, additional, Busson, Philippe, additional, Barroso, Bruno, additional, Larrieu, Jean-Marc, additional, Giendaj, Catherine Louvet, additional, Malkoun, Imad, additional, Hautecoeur, Patrick, additional, Kwiatkowski, Arnaud, additional, Pouliquen, Andre, additional, Garrigues, Guillaume, additional, Delerue, Olivier, additional, Giraud, Pierric, additional, Gere, Julien, additional, Vaunaize, Jean, additional, Dereeper, Olivier, additional, Seiller, Nicolas, additional, Alsassa, Roger, additional, Vlaicu, Mihaela, additional, Neuville, Veronique, additional, Faucheux, Jean Marc, additional, Bernady, Patricia, additional, Fanjaud, Guy, additional, Viallet, François, additional, Schroeter, Michael, additional, Schlemilch-Paschen, Sylke, additional, Lange, Thomas, additional, Bohr, Kin-Arno, additional, Jendroska, Klaus, additional, Rehkopf, Elisabeth, additional, Bergmann, Arnfin, additional, Kleinschnitz, Christoph, additional, Postert, Thomas, additional, Scholz, Peter, additional, Mauz, Uwe, additional, Stratmann, Hubert, additional, Siefjediers, Veneta, additional, Prantl, Martin, additional, Gehring, Klaus, additional, Zellner, Ruth, additional, Junge, Kathrin, additional, Zellner, Anton, additional, Bacay, Valerina, additional, Schlegel, Eugen, additional, Polzer, Udo, additional, Strauss, Erik, additional, Link, Andreas, additional, Stenzel, Christoph, additional, Freidel, Matthias, additional, Drews, Joachim, additional, Neudert, Christian, additional, Schmitz, Frank, additional, Jaeger, Joachim, additional, Masri, Said, additional, Heuberger, Wolfgang, additional, Trausch, Beate, additional, Ruhnke, Oliver, additional, Scarel, Serena, additional, Bach, Kathlen, additional, Ernst, Michael, additional, Landefeld, Harald, additional, Richter, Nils, additional, Schmidt, Stephan, additional, Krause, Michaela, additional, Dressel, Alezander, additional, Ruth, Roland, additional, Anvari, Kerstin, additional, Gossling, Jens, additional, Schenk, Christoph, additional, Tiedge, Oliver, additional, Bode, Lutz, additional, Eder, Hans-Thomas, additional, Pfeffer, Oliver, additional, Krug, Reinhard, additional, Lassek, Christoph, additional, Fleischer, Eberhard, additional, Meuth, Sven, additional, Klotz, Luisa Hildegard, additional, Peglau, Ines, additional, Kukowski, Borries, additional, Herting, Birgit, additional, Guthke, Kersten, additional, Schierenbeck, Jurgen, additional, Brockmeier, Bernd, additional, Albrecht, Holger, additional, Wuttke, Matthias, additional, Augspach-Hofmann, Regine, additional, Gunther, Stefan, additional, Redbrake, Martin, additional, Franke, Christian, additional, Buchner, Klaus, additional, Gratz, Thomas, additional, Horn, Rolf, additional, Doemges, Frank, additional, Schreiber, Martin, additional, Brosch, Thomas, additional, Horn, Markus, additional, Kittlitz, Matthias, additional, Vulturius, Gabriele, additional, Hinse, Paul, additional, Malessa, Rolf, additional, Wiehler, Stephan, additional, Katsarava, Zaza, additional, Kastrup, Oliver, additional, Kausch, Ulrich, additional, Gullekes, Martin, additional, Fickinger, Markus, additional, Wenzel, Wilhelm, additional, Botefur, Ingolf C., additional, Reifschneider, Gerd, additional, Rauer, Sebastian, additional, Lang, Michael, additional, Harms, Lutz, additional, Eckhardt, Ulrich, additional, Cursiefen, Simone, additional, Linker, Ralf, additional, Angstwurm, Klemens, additional, Haas, Judith, additional, Schuetze, Ivo, additional, Rohm, Eva, additional, Stienker-Fisse, H., additional, Sailer, Michael, additional, Bohringer, Johannes, additional, Maurer, Mathias, additional, Bause, Eberhard, additional, Wersching, Ronald, additional, Dachsel, Reinhardt, additional, Domke, Sylke, additional, Hoffman, Frank, additional, Tackenberg, Bjorn, additional, Roch, Kerstin, additional, Ziebold, Uwe, additional, Kallmann, Boris, additional, Buehler, Bernhard, additional, Faiss, Judith, additional, Faiss, Juergen, additional, Schimrigk, Sebastian, additional, Menges, Christian, additional, Knop, Karl Christian, additional, Koehler, Wolfgang, additional, Siever, Arno, additional, Bufler, Johannes, additional, Gramsl, Georg, additional, Kuhnler, Benedicta, additional, Maschke, Matthias, additional, Stogbauer, Florian, additional, Staude, Lisa, additional, Bethke, Florian, additional, Bitsch, Andreas, additional, Harmjanz, Arndt D., additional, Windsheimer, Jorg, additional, Kieseier, Bernd C., additional, Berkenfeld, Ralf, additional, Tumani, Hayrettin, additional, Kirsch, Michael, additional, Wildemann, Brigitte, additional, Daniels, Regina, additional, Gottwald, Klaus, additional, Elias, Wolfgang-Gerhard, additional, Hoffmann, Olaf, additional, Schwab, Matthias, additional, Pilz, Christopher, additional, Klostermann, Fabian, additional, Hellwig, Kerstin, additional, Berthele, Achim, additional, Bayas, Antonios, additional, Molitor, Daniel, additional, Grothe, Christoph, additional, Wagner, Bert, additional, Karageorgiou, Klimentini, additional, Mitsikostas, Dimosthenis, additional, Kodounis, Antonios, additional, Plaitakis, Andreas, additional, Papadimitriou, Alexandros, additional, Grigoriadis, Nikolaos, additional, Vlaikidis, Nikolaos, additional, Koutlas, Evaggelos, additional, Kyritsis, Athanassios, additional, Papathanassopoulos, Panagiotis, additional, Makris, Nikolaos, additional, Tavernarakis, Antonios, additional, Scarpini, Elio, additional, Montanari, Enrico, additional, Marrosu, Maria Giovanna, additional, Trojano, Maria, additional, Amato, Maria Pia, additional, Rottoli, Mariarosa, additional, Lugaresi, Alessandra, additional, Florio, Ciro, additional, Gasperini, Claudio, additional, Grimaldi, Luigi, additional, Millefiorini, Enrico, additional, Koudriavtseva, Tatiana, additional, Perla, Franco, additional, Mantegazza, Renato, additional, Bertolotto, Antonio, additional, Ghezzi, Angelo, additional, Aguilar, Sandra Quinones, additional, Eisenberg, Eli Skromne, additional, Lopez, Leondardo Llamas, additional, Estudillo, Rocio Marquez, additional, Schrijver, H.M., additional, Wittebol, M.C., additional, Baart, J.C., additional, van Golde, A.E.L., additional, Hengstman, G.J.D., additional, Pop, P.H.M., additional, Bos (Geldrop), M., additional, Medaer, R., additional, Schyns-Soeterboek, Angelique, additional, van der Zwart, A., additional, van Diepen, A.J.H., additional, Verheul, G.A.M., additional, Verhagen, W.I.M., additional, Bos (Helmond), M., additional, Witjes, R.J.G.M., additional, Sinnige, L.G.F., additional, van Munster, E.Th.L., additional, Sanders, E.A.C.M., additional, van Dijl, Ron, additional, Hupperts, R.M.M., additional, Frequin, S.T.F.M., additional, Visser, L.H., additional, Henselmans, J.M.L., additional, Moll, J.W.B., additional, Midgard, Rune, additional, Myhr, Kjell Morten, additional, Edland, Astrid, additional, Telstad, Wenche, additional, Hognestad, Tone, additional, Lund, Christian, additional, Hovdal, Harald, additional, Kamaljit, Kaur, additional, Schepel, Jan, additional, Hogenesch, Roelfien Ida, additional, Schüler, Stephan, additional, Odeh, Francis, additional, Alstadhaug, Karl B., additional, Korsgaard, Olav, additional, Farbu, Elisabeth, additional, Ingvaldsen, Teis Barclay, additional, Soares (SCO), Diana, additional, Rente, José, additional, Guerra, José Manuel Costa, additional, Morganho, Armando, additional, Leitão, António, additional, de Sá, João, additional, Sá, Maria José, additional, Marques, Pinto, additional, Veloso, Mário, additional, Baptista, Miguel Viana, additional, Szilasiová, Jarmila, additional, Copikova-Cudrakova, Daniela, additional, Prochazkova, Lubica, additional, Klimová, Eleonóra, additional, Donath, Vladimir, additional, Brozman, Miroslav, additional, Ramo, Cristina, additional, Ruiz, Domingo Pérez, additional, Hernández, Carmen Calles, additional, Sola, María Eugenia Marzo, additional, Moro, Roberto Suarez, additional, Vidal, Jose Antonio, additional, Rodríguez, Ana Belén Caminero, additional, Ozaeta, Gisela Martin, additional, Nadal, Jordi Batlle, additional, Esquide, Amaya Alvarez de Arcaya, additional, Urtaza, Javier Olascoaga, additional, Martínez-Yélamos, Sergio, additional, Arbizu, Txomin, additional, Torrenta, Lluis Ramio i, additional, Boggild, Mike, additional, Wilson, Martin, additional, Al-Araji, Adnan, additional, Nicholas, Richard, additional, Harrower, Timothy, additional, Redmond, Ian, additional, Wolf, Tilo, additional, Osei-Bonsu, Michael, additional, Mazibrada, Gordon, additional, Rog, David, additional, Cottrell, David, additional, Constantinescu, Cris, additional, Gray, Orla, additional, Belhag, Mohamed, additional, Shehu, Abdullah, additional, Rashid, Waqar, additional, and Duddy, Martin, additional

Published
2018
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14. Multiple sclerosis

Author

Knippenberg, S., Damoiseaux, J.G.M.C., Hupperts, R.M.M., Shoenfeld, Meroni, Interne Geneeskunde, Klinische Neurowetenschappen, and RS: NUTRIM - R4 - Gene-environment interaction

Published
2012

22. Is empathy related to work participation, work role functioning and productivity in multiple sclerosis patients?

Author

Gorp, D.A.M. van, Hiele, van der K., Heerings, M., Jongen, P.J., van Lieshout, I., Reneman, M.F., van der Klink, J.J.L., Arnoldus, E., Beenakker, E.A.C., Bos, H.M., van Eijk, J.J.J., Fermont, J., Frequin, S., van Geel, B.M., Hengstman, G.J.D., Hoitsma, E., Hupperts, R.M.M., Moll, J.W.B., Mostert, J.P., Pop, P., Verhagen, W., Verheul, F., Zemel, D., Middelkoop, H.A.M., Visser, L. H., Extremities Pain and Disability (EXPAND), A just and caring society, University of Humanistic Studies, and Care Ethics

Abstract

Background: Empathy refers to the ability to understand other persons intentions, predict their behaviour and experience an emotion triggered by their emotion. It allows us to interact with the social world and has been associated with improved labor climate and teamwork. Empathy has a down side as well, considering its associations with Neuroticism and fatigue in professionals caring for suffering people. A few studies have reported reduced degrees of empathy, empathic concern and fantasy in multiple sclerosis (MS) patients. The current study examines relations between empathy and work participation, work role functioning , productivity and other clinical and personal variables in employed relapsing-remitting MS patients. Methods: In the context of the MS@Work study, 19 unemployed and 148 employed patients with relapsing-remitting MS completed the Baron-Cohen"s Empathy Quotient and questionnaires on demographics, work role functioning and productivity, physical and cognitive functioning, fatigue, depression, anxiety, personality and coping. Mann-Whitney U-tests were used to examine group differences in empathy. Correlation analyses and stepwise linear regression analysis were used to examine relations between empathy and work role functioning, productivity, demographic, clinical and personal variables in employed MS patients. The significance level was set at 0.05. We used p< =0.001 for the correlations. Results: Empathy was, although not statistically significant, lower in unemployed as compared with employed MS patients (U=1059.50, p=.081, r=.14). Empathy was higher in females (U=1409.50, p=.002, ) and in patients with a higher educational level (H(7)=17,99, p=.012). We found significant relations between empathy and the personality traits Agreeableness (rs=.560, p < .001), Conscientiousness (rs=.287, p< .001) and Extraversion (rs=.263, p=.001). Empathy did not correlate with work role functioning and productivity. In a stepwise linear regression, controlling for gender and education, the personality trait Agreeableness (β=.50, t(147) = 7.21, p< .001) was positively associated with empathy (R²=.41, p< .001). Conclusions: Empathy did not differ significantly between employed and unemployed MS patients. Empathy was not associated with work role functioning and productivity in employed MS patients, but was associated with the personality trait Agreeableness. Longitudinal studies are needed to examine further relations between empathy and employment.

23. Comparative efficacy of first-line natalizumab vs IFN-β or glatiramer acetate in relapsing MS

Author

Spelman, Tim, Kalincik, Tomas, Jokubaitis, Vilija, Zhang, Annie, Pellegrini, Fabio, Wiendl, Heinz, Belachew, Shibeshih, Hyde, Robert, Verheul, Freek, Lugaresi, Alessandra, Havrdova, Eva, Horakova, Dana, Grammond, Pierre, Duquette, Pierre, Prat, Alexandre, Iuliano, Gerardo, Terzi, Murat, Izquierdo, Guillermo, Hupperts, Raymond M. M., Boz, Cavit, Pucci, Eugenio, Giuliani, Giorgio, Sola, Patrizia, Spitaleri, Daniele L. A., Lechner-Scott, Jeannette, Bergamaschi, Roberto, Grand'Maison, Francois, Granella, Franco, Kappos, Ludwig, Trojano, Maria, Butzkueven, Helmut, MSBase Investigators TOP Investiga, DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE, OMÜ, Spelman, T, Kalincik, T, Jokubaitis, V, Zhang, A, Pellegrini, F, Wiendl, H, Belachew, S, Hyde, R, Verheul, F, Lugaresi, A, Havrdová, E, Horáková, D, Grammond, P, Duquette, P, Prat, A, Iuliano, G, Terzi, M, Izquierdo, G, Hupperts, R.M.M, Boz, C, Pucci, E, Giuliani, G, Sola, P, Spitaleri, D.L.A, Lechner-Scott, J, Bergamaschi, R, Grand'Maison, F, Granella, F, Kappos, L, Trojano, M, Butzkueven, H., RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Med Staf Spec Neurologie (9), Klinische Neurowetenschappen, [Spelman, Tim] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3010, Australia, [Kalincik, Tomas] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3010, Australia, [Jokubaitis, Vilija] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3010, Australia, [Butzkueven, Helmut] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3010, Australia, [Spelman, Tim] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Melbourne, Vic 3010, Australia, [Kalincik, Tomas] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Melbourne, Vic 3010, Australia, [Jokubaitis, Vilija] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Melbourne, Vic 3010, Australia, [Butzkueven, Helmut] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Melbourne, Vic 3010, Australia, [Zhang, Annie] Biogen Idec Inc, Cambridge, MA USA, [Pellegrini, Fabio] Biogen Idec Inc, Cambridge, MA USA, [Belachew, Shibeshih] Biogen Idec Inc, Cambridge, MA USA, [Hyde, Robert] Biogen Idec Inc, Cambridge, MA USA, [Wiendl, Heinz] Univ Munster, Dept Neurol, Munster, Germany, [Verheul, Freek] Groene Hart Ziekenhuis, Gouda, Netherlands, [Lugaresi, Alessandra] Univ G DAnnunzio, Dept Neurosci Imaging & Clin Sci, MS Ctr, Chieti, Italy, [Havrdova, Eva] Charles Univ Prague, Dept Neurol, MS Ctr, Fac Med 1, Prague, Czech Republic, [Horakova, Dana] Charles Univ Prague, Dept Neurol, MS Ctr, Fac Med 1, Prague, Czech Republic, [Grammond, Pierre] Ctr Readaptat Deficience Phys Chaudiere Appalache, Levis, PQ, Canada, [Duquette, Pierre] Hop Notre Dame De Bon Secours, Montreal, PQ, Canada, [Prat, Alexandre] Hop Notre Dame De Bon Secours, Montreal, PQ, Canada, [Iuliano, Gerardo] Osped Riuniti Salerno, Salerno, Italy, [Terzi, Murat] 19 Mayis Univ, Fac Med, Samsun, Turkey, [Izquierdo, Guillermo] Hosp Univ Virgen Macarena, Seville, Spain, [Hupperts, Raymond M. M.] Orbis Med Ctr, Sittard Geleen, Netherlands, [Boz, Cavit] Farabi Hosp, KTU Med Fac, Trabzon, Turkey, [Pucci, Eugenio] ASUR Marche AV3, Neurol Unit, Macerata, Italy, [Giuliani, Giorgio] ASUR Marche AV3, Neurol Unit, Macerata, Italy, [Sola, Patrizia] Nuovo Osped Civile S Agostino, Modena, Italy, [Spitaleri, Daniele L. A.] AORN San Giuseppe Moscati, Avellino, Italy, [Lechner-Scott, Jeannette] John Hunter Hosp, Newcastle, NSW, Australia, [Bergamaschi, Roberto] IRCCS Mondino, Neurol Inst, Pavia, Italy, [Grand'Maison, Francois] Hop Charles LeMoyne, Neuro Rive Sud, Longueuil, PQ, Canada, [Granella, Franco] Univ Parma, I-43100 Parma, Italy, [Kappos, Ludwig] Univ Basel Hosp, Dept Neurol, Basel, Switzerland, [Trojano, Maria] Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, I-70121 Bari, Italy, [Butzkueven, Helmut] Monash Univ, Dept Neurol, Eastern Hlth, Clayton, Vic 3800, Australia, NHMRC, NHMRC Center for Research Excellence, MSBase Foundation, Merck Serono, Biogen, Novartis Pharma, Bayer-Schering, Sanofi-Aventis, BioCSL, and Czech Ministry of Education

Subjects
Risk, Oncology, medicine.medical_specialty, Outcomes, 03 medical and health sciences, 0302 clinical medicine, Natalizumab, Patient selection, Internal medicine, Disease-activity, Medicine, 030212 general & internal medicine, Long-term safety, Glatiramer acetate, Autoimmune disease, Predictors, business.industry, Progressive multifocal leukoencephalopathy, Multiple sclerosis, Research, Double-blind, Interferon-beta, medicine.disease, Remitting multiple-sclerosis, Benefits, Institutional repository, Physical therapy, Population study, Observational study, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Jokubaitis, Vilija G./0000-0002-3942-4340; pietrolongo, erika/0000-0002-6311-5994; Horakova, Dana/0000-0003-1915-0036; Lugaresi, Alessandra/0000-0003-2902-5589; Belachew, Shibeshih/0000-0003-3976-1950; Havrdova, Eva Kubala/0000-0002-9543-4359; Trojano, Maria/0000-0002-6329-8946; Butzkueven, Helmut/0000-0003-3940-8727; Kalincik, Tomas/0000-0003-3778-1376; pucci, eugenio/0000-0001-7606-7330 WOS: 000392602400009 Background: We compared efficacy and treatment persistence in treatment-naive patients with relapsing-remitting multiple sclerosis (RRMS) initiating natalizumab compared with interferon-beta (IFN-beta)/glatiramer acetate (GA) therapies, using propensity score-matched cohorts from observational multiple sclerosis registries. Methods: The study population initiated IFN-beta/GA in the MSBase Registry or natalizumab in the Tysabri Observational Program, had >= 3 months of on-treatment follow-up, and had active RRMS, defined as >= 1 gadolinium-enhancing lesion on cerebral MRI at baseline or >= 1 relapse within the 12 months prior to baseline. Baseline demographics and disease characteristics were balanced between propensity-matched groups. Annualized relapse rate (ARR), time to first relapse, treatment persistence, and disability outcomes were compared between matched treatment arms in the total population (n = 366/group) and subgroups with higher baseline disease activity. Results: First-line natalizumab was associated with a 68% relative reduction in ARR from a mean (SD) of 0.63 (0.92) on IFN-beta/GA to 0.20 (0.63) (p [signed-rank] < 0.0001), a 64% reduction in the rate of first relapse (hazard ratio [HR] 0.36, 95% confidence interval [CI] 0.28-0.47; p < 0.001), and a 27% reduction in the rate of discontinuation (HR 0.73, 95% CI 0.58-0.93; p = 0.01), compared with first-line IFN-beta/GA therapy. Confirmed disability progression and area under the Expanded Disability Status Scale-time curve analyses were not significant. Similar relapse and treatment persistence results were observed in each of the higher disease activity subgroups. Conclusions: This study provides Class IV evidence that first-line natalizumab for RRMS improves relapse and treatment persistence outcomes compared to first-line IFN-beta/GA. This needs to be balanced against the risk of progressive multifocal leukoencephalopathy in natalizumab-treated patients. Classification of evidence: This study provides Class IV evidence that first-line natalizumab for RRMS improves relapse rates and treatment persistence outcomes compared to first-line IFN-beta/GA. NHMRCNational Health and Medical Research Council of Australia [628856, 1071124, 1032484, 1083539]; NHMRC Center for Research ExcellenceNational Health and Medical Research Council of Australia [1001216]; MSBase Foundation; Merck SeronoMerck SeronoMerck & Company; BiogenBiogen; Novartis Pharma; Bayer-ScheringBayer AG; Sanofi-AventisSanofi-Aventis; BioCSL; Czech Ministry of EducationMinistry of Education, Youth & Sports - Czech Republic [PRVOUK-P26/LF1/4] Supported by the NHMRC Career Development Award (Clinical) to H.B. (ID628856), NHMRC Early Career Fellowship (1071124), NHMRC Project Grants (1032484 and 1083539), NHMRC Center for Research Excellence (Grant ID 1001216), and the MSBase Foundation. The MSBase Foundation is a not-for-profit organization that receives support from Merck Serono, Biogen, Novartis Pharma, Bayer-Schering, Sanofi-Aventis, and BioCSL. The Tysabri Observational Program is fully funded by Biogen. E. Havrdova and D. Horakova have been supported by Research Grant of Czech Ministry of Education, PRVOUK-P26/LF1/4.

Published
2016

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