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BACKGROUND: Postoperative delirium (POD) is a common complication following cardiac surgery and increases postoperative morbidity and mortality. Intraoperative electroencephalogram (EEG) burst suppression suggests excessively deep anesthesia and predicts POD. Use of remimazolam provides a stable hemodynamic status and an appropriate depth of anesthesia. We aim to assess remimazolam administered for anesthesia and sedation in elderly patients having cardiac surgery. METHODS: This is a randomized controlled clinical trial with noninferiority design. A total of 260 elderly patients aged equal to or greater than 60 years undergoing cardiac surgery will be randomly allocated to receive remimazolam or propofol (1:1) for general anesthesia and postoperative sedation until extubation. The primary outcome is the cumulative time with EEG burst suppression which is obtained from the SedLine system. The noninferiority margin is 2.0 min. The secondary outcomes include the POD occurrence within the first 5 days postoperatively and the duration of perioperative hypotension. DISCUSSION: This noninferiority trial is the first to evaluate the effect of perioperative remimazolam administration on EEG burst suppression, POD occurrence, and duration of hypotension in elderly patients who undergo cardiac surgery. TRIAL REGISTRATION: Chinese Clinical Trial Registry (ChiCTR2200056353).

Postoperative complications are common after major surgical procedures, leading to increased morbidity and mortality. Regional cerebral oxygen saturation (rScO2) reflects cerebral and global perfusion, and thus it can be used to guide hemodynamic management. We aim to explore the effect of rScO2-guided blood pressure management strategy on postoperative major complications in older adults who undergo major noncardiac surgery. This randomized controlled clinical trial includes a total of 400 elderly patients receiving major noncardiac surgery and general anesthesia. Patients will be randomized (1:1) to one of two blood pressure management groups: a standard care group (targeting mean arterial pressure >65 mmHg or within 20% of baseline value), and a rScO2-guided group (absolute value of rScO2 >60% or decrease in rScO2

The Tarim River Basin (TRB) faces significant ecological challenges due to global warming, making it essential to understand the changes in the climates of its sub-basins for effective management. With this aim, data from national meteorological stations, ERA5_Land, and climate indices from 1961 to 2021 were used to analyze the temperature and precipitation variations in the TRB and its sub-basins and to assess their climate sensitivity. Our results showed that (1) the annual mean temperature increased by 0.2 °C/10a and precipitation increased by 7.1 mm/10a between 1961 and 2021. Moreover, precipitation trends varied significantly among the sub-basins, with that in the Aksu River Basin increasing the most (12.9 mm/10a) and that in the Cherchen River Basin increasing the least (1.9 mm/10a). Moreover, ERA5_Land data accurately reproduced the spatiotemporal patterns of temperature (correlation 0.92) and precipitation (correlation 0.72) in the TRB. (2) Empirical Orthogonal Function analysis identified the northern sections of the Kaidu, Weigan, and Yerqiang river basins as centers of temperature sensitivity and the western part of the Kaidu and Cherchen River Basin as the center of precipitation sensitivity. (3) Global warming is closely correlated with sub-basin temperature (correlation above 0.5) but weakly correlated with precipitation (correlation 0.2~0.5). TRB temperatures were found to have a positive correlation with AMO, especially in the Hotan, Kashgar, and Aksu river basins, and a negative correlation with AO and NAO, particularly in the Keriya and Hotan river basins. Precipitation correlations between the climate indices were complex and varied across the different basins. [ABSTRACT FROM AUTHOR]

The urban heat island (UHI) effect is one of the most prominent surface climate changes driven by human activities. This study examines the UHI characteristics and influencing factors in the Southern Xinjiang urban agglomeration using MODIS satellite data combined with observational datasets. Our results reveal a significant increase in impervious surfaces in the region between 1995 and 2015, with the most rapid expansion occurring from 2010 to 2015. This urban expansion is the primary driver of changes in UHI intensity. The analysis from 2000 to 2015 shows substantial spatial variation in UHI effects across cities. Hotan recorded the highest annual average daytime UHI intensity of 3.7 °C, while Aksu exhibited the lowest at approximately 1.6 °C. Daytime UHI intensity generally increased during the study period, with the highest intensities observed in the summer. However, nighttime UHI trends varied across cities, with most showing an increase in intensity. Temperature, precipitation, and aerosol optical depth (AOD) were identified as the main factors influencing annual average daytime UHI intensity, while PM10 concentration showed a weak and inconsistent correlation with UHI intensity, varying by city and season. [ABSTRACT FROM AUTHOR]

Objective: Combined with the determination of macromolecular protein, amino acid and total protein, a quantitative analysis method for the content of small molecular peptides in infant formula milk powder was established. Methods: The contents of total protein, polymer protein and free amino acid in infant formula milk powder were determined by Kjeldahl nitrogen determination method, gravimetric method and ion exchange chromatography, and then the contents of small molecular protein peptide were calculated. Results: The precision RSD of the macromolecular protein detection (n=6) was 0.74%; The recovery rates of the 17 kinds of amino acids were 91.0%~103.2%, and the relative deviations of the detection results were 0.6%~ 2.5%. The recovery rates of small molecular weight peptides were 95.2%~98.2%. Conclusion: The established method has been validated by methodology, with good precision and recovery rate, and can be used for the determination of small molecular peptides in infant formula milk powder.

Dust and air pollution events are increasingly occurring around the Taklimakan Desert in southern Xinjiang and in the urban areas of northern Xinjiang. Predicting such events is crucial for the advancement, growth, and prosperity of communities. This study evaluated a dust and air pollution forecasting system based on the Weather Research and Forecasting model coupled with the China Meteorological Administration Chemistry Environment (WRF-CUACE) model using ground and satellite observations. The results showed that the forecasting system accurately predicted the formation, development, and termination of dust events. It demonstrated good capability for predicting the evolution and spatial distribution of dust storms, although it overestimated dust intensity. Specifically, the correlation coefficient (R) between simulated and observed PM10 was up to 0.85 with a mean absolute error (MAE) of 721.36 µg·m−3 during dust storm periods. During air pollution events, the forecasting system displayed notable variations in predictive accuracy across various urban areas. The simulated trends of PM2.5 and the Air Quality Index (AQI) closely aligned with the actual observations in Ürümqi. The R for simulated and observed PM2.5 concentrations at 24 and 48 h intervals were 0.60 and 0.54, respectively, with MAEs of 28.92 µg·m−3 and 29.10 µg·m−3, respectively. The correlation coefficients for simulated and observed AQIs at 24 and 48 h intervals were 0.79 and 0.70, respectively, with MAEs of 24.21 and 27.56, respectively. The evolution of the simulated PM10 was consistent with observations despite relatively high concentrations. The simulated PM2.5 concentrations in Changji and Shihezi were notably lower than those observed, resulting in a lower AQI. For PM10, the simulation–observation error was relatively small; however, the trends were inconsistent. Future research should focus on optimizing model parameterization schemes and emission source data. [ABSTRACT FROM AUTHOR]

Coupling solar-induced chlorophyll fluorescence (SIF) with gross primary productivity (GPP) for ecological function integration research presents numerous uncertainties, especially in ecologically fragile and climate-sensitive arid regions. Therefore, evaluating the suitability of SIF data for estimating GPP and the feasibility of improving its accuracy in the northern region of Xinjiang is of profound significance for revealing the spatial distribution patterns of GPP and the strong coupling relationship between GPP and SIF in arid regions, achieving the goal of "carbon neutrality" in arid regions. This study is based on multisource SIF satellite data and GPP observation data from sites in three typical ecosystems (cultivated and farmlands, pasture grasslands, and desert vegetation). Two precision improvement methods (canopy and linear) are used to couple multiple indicators to determine the suitability of multisource SIF data for GPP estimation and the operability of accuracy improvement methods in arid regions reveal the spatial characteristics of SIF (GPP). The results indicate the following. (1) The interannual variation of GPP shows an inverted "U" shape, with peaks values in June and July. The cultivated and farmland areas have the highest peak value among the sites (0.35 gC/m2/month). (2) The overall suitability ranking of multisource SIF satellite products for GPP estimation in arid regions is RTSIF > CSIF > SIF_OCO2_005 > GOSIF. RTSIF shows better suitability in the pasture grassland and cultivated and farmland areas (R2 values of 0.85 and 0.84, respectively). (3) The canopy method is suitable for areas with a high leaf area proportion (R2 improvement range: 0.05–0.06), while the linear method is applicable across different surface types (R2 improvement range: 0.01–0.13). However, the improvement effect of the linear method is relatively weaker in areas with high vegetation cover. (4) Combining land use data, the overall improvement of SIF (GPP) is approximately 0.11%, and the peak values of its are mainly distributed in the northern and southern slopes of the Tianshan Mountains, while the low values are primarily found in the Gurbantunggut Desert. The annual mean value of SIF (GPP) is about 0.13 mW/m2/nm/sr. This paper elucidates the applicability of SIF for GPP estimation and the feasibility of improving its accuracy, laying the theoretical foundation for the spatiotemporal coupling study of GPP and SIF in an arid region, and providing practical evidence for achieving carbon neutrality goals. [ABSTRACT FROM AUTHOR]