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4. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

Author

Stagno, J. R., Liu, Y., Bhandari, Y. R., Conrad, C. E., Panja, S., Swain, M., Fan, L., Nelson, G., Li, C., Wendel, D. R., White, T. A., Coe, J. D., Wiedorn, M. O., Knoska, J., Oberthuer, D., Tuckey, R. A., Yu, P., Dyba, M., Tarasov, S. G., Weierstall, U., Grant, T. D., Schwieters, C. D., Zhang, J., Ferr-DAmar, A. R., Fromme, P., Draper, D. E., Liang, M., Hunter, M. S., Boutet, S., Tan, K., Zuo, X., Ji, X., Barty, A., Zatsepin, N. A., Chapman, H. N., Spence, J. C. H., Woodson, S. A., and Wang, Y.-X.

Subjects
Crystallography -- Methods, RNA sequencing -- Methods, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): J. R. Stagno [1]; Y. Liu [1]; Y. R. Bhandari [1]; C. E. Conrad [2, 3]; S. Panja [4]; M. Swain [1]; L. Fan [5]; G. Nelson [6]; C. [...]

Published
2017
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14. Diffraction data from aerosolized Coliphage PR772 virus particles imaged with the Linac Coherent Light Source

Author

Department of Molecular Biology and Genetics, Demirci, Hasan (ORCID 0000-0002-9135-5397 & YÖK ID 307350), Li, H.; Nazari, R.; Abbey, B.; Alvarez, R.; Aquila, A.; Ayyer, K.; Barty, A.; Berntsen, P.; Bielecki, J.; Pietrini, A.; Bucher, M.; Carini, G.; Chapman, H. N.; Contreras, A.; Daurer, B. J.; Flűckiger, L.; Frank, M.; Hajdu, J.; Hantke, M. F.; Hogue, B. G.; Hosseinizadeh, A.; Hunter, M. S.; Jönsson, H. O.; Kirian, R. A.; Kurta, R. P.; Loh, D.; Maia, F. R. N. C.; Mancuso, A. P.; Morgan, A. J.; McFadden, M.; Muehlig, K.; Munke, A.; Reddy, H. K. N.; Nettelblad, C.; Ourmazd, A.; Rose, M.; Schwander, P.; Marvin, Seibert M.; Sellberg, J. A.; Sierra, R. G.; Sun, Z.; Svenda, M.; Vartanyants, I. A.; Walter, P.; Westphal, D.; Williams, G.; Xavier, P. L.; Yoon, C. H.; Zaare, S., Department of Molecular Biology and Genetics, Demirci, Hasan (ORCID 0000-0002-9135-5397 & YÖK ID 307350), and Li, H.; Nazari, R.; Abbey, B.; Alvarez, R.; Aquila, A.; Ayyer, K.; Barty, A.; Berntsen, P.; Bielecki, J.; Pietrini, A.; Bucher, M.; Carini, G.; Chapman, H. N.; Contreras, A.; Daurer, B. J.; Flűckiger, L.; Frank, M.; Hajdu, J.; Hantke, M. F.; Hogue, B. G.; Hosseinizadeh, A.; Hunter, M. S.; Jönsson, H. O.; Kirian, R. A.; Kurta, R. P.; Loh, D.; Maia, F. R. N. C.; Mancuso, A. P.; Morgan, A. J.; McFadden, M.; Muehlig, K.; Munke, A.; Reddy, H. K. N.; Nettelblad, C.; Ourmazd, A.; Rose, M.; Schwander, P.; Marvin, Seibert M.; Sellberg, J. A.; Sierra, R. G.; Sun, Z.; Svenda, M.; Vartanyants, I. A.; Walter, P.; Westphal, D.; Williams, G.; Xavier, P. L.; Yoon, C. H.; Zaare, S.

Abstract

Single Particle Imaging (SPI) with intense coherent X-ray pulses from X-ray free-electron lasers (XFELs) has the potential to produce molecular structures without the need for crystallization or freezing. Here we present a dataset of 285,944 diffraction patterns from aerosolized Coliphage PR772 virus particles injected into the femtosecond X-ray pulses of the Linac Coherent Light Source (LCLS). Additional exposures with background information are also deposited. The diffraction data were collected at the Atomic, Molecular and Optical Science Instrument (AMO) of the LCLS in 4 experimental beam times during a period of four years. The photon energy was either 1.2 or 1.7 keV and the pulse energy was between 2 and 4 mJ in a focal spot of about 1.3 μm x 1.7 μm full width at half maximum (FWHM). The X-ray laser pulses captured the particles in random orientations. The data offer insight into aerosolised virus particles in the gas phase, contain information relevant to improving experimental parameters, and provide a basis for developing algorithms for image analysis and reconstruction.

Published
2020

15. Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer : Aggregate data and individual patient data meta-analyses

Author

Buffart, L. M., Schreurs, M. A. C., Abrahams, H. J. G., Kalter, J., Aaronson, N. K., Jacobsen, P. B., Newton, R. U., Courneya, K. S., Armes, J., Arving, Cecilia, Braamse, A. M., Brandberg, Y., Dekker, J., Ferguson, R. J., Gielissen, M. F., Glimelius, Bengt, Goedendorp, M. M., Graves, K. D., Heiney, S. P., Horne, R., Hunter, M. S., Johansson, Birgitta, Northouse, L. L., Oldenburg, H. S., Prins, J. B., Savard, J., van Beurden, M., van den Berg, S. W., Brug, J., Knoop, H., Verdonck-de Leeuw, I. M., Buffart, L. M., Schreurs, M. A. C., Abrahams, H. J. G., Kalter, J., Aaronson, N. K., Jacobsen, P. B., Newton, R. U., Courneya, K. S., Armes, J., Arving, Cecilia, Braamse, A. M., Brandberg, Y., Dekker, J., Ferguson, R. J., Gielissen, M. F., Glimelius, Bengt, Goedendorp, M. M., Graves, K. D., Heiney, S. P., Horne, R., Hunter, M. S., Johansson, Birgitta, Northouse, L. L., Oldenburg, H. S., Prins, J. B., Savard, J., van Beurden, M., van den Berg, S. W., Brug, J., Knoop, H., and Verdonck-de Leeuw, I. M.

Abstract

PURPOSE: This study evaluated the effects of coping skills training (CST) on symptoms of depression and anxiety in cancer patients, and investigated moderators of the effects. METHODS: Overall effects and intervention-related moderators were studied in meta-analyses of pooled aggregate data from 38 randomized controlled trials (RCTs). Patient-related moderators were examined using linear mixed-effect models with interaction tests on pooled individual patient data (n = 1953) from 15 of the RCTs. RESULTS: CST had a statistically significant but small effect on depression (g = -0.31,95% confidence interval (CI) = -0.40;-0.22) and anxiety (g = -0.32,95%CI = -0.41;-0.24) symptoms. Effects on depression symptoms were significantly larger for interventions delivered face-to-face (p = .003), led by a psychologist (p = .02) and targeted to patients with psychological distress (p = .002). Significantly larger reductions in anxiety symptoms were found in younger patients (pinteraction < 0.025), with the largest reductions in patients <50 years (β = -0.31,95%CI = -0.44;-0.18) and no significant effects in patients ≥70 years. Effects of CST on depression (β = -0.16,95%CI = -0.25;-0.07) and anxiety (β = -0.24,95%CI = -0.33;-0.14) symptoms were significant in patients who received chemotherapy but not in patients who did not (pinteraction < 0.05). CONCLUSIONS: CST significantly reduced symptoms of depression and anxiety in cancer patients, and particularly when delivered face-to-face, provided by a psychologist, targeted to patients with psychological distress, and given to patients who were younger and received chemotherapy.

Published
2020
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18. A fixed-target platform for serial femtosecond crystallography in a hydrated environment

Author

Shelby, M. L., primary, Gilbile, D., additional, Grant, T. D., additional, Seuring, C., additional, Segelke, B. W., additional, He, W., additional, Evans, A. C., additional, Pakendorf, T., additional, Fischer, P., additional, Hunter, M. S., additional, Batyuk, A., additional, Barthelmess, M., additional, Meents, A., additional, Coleman, M. A., additional, Kuhl, T. L., additional, and Frank, M., additional

Published
2020
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21. Abstracts of Papers Presented at The International Workshop onBemisia Spp.: October 3–7, 1994 Shoresh Hotel and Conference Center, Shoresh, Israel

Author

Perring, Thomas M., Nelson, D. R., Buckner, J. S., Frohlich, D. R., Brown, J. K., Hong, W. Lei, Tjallingii, Freddy, Lenteren, Joop C. van, Rosell, R. C., Bedford, I. D., Markham, P. G., Guershon, Moshe, Gerling, Dan, Salas, Jorge, Mendoza, Omar, Cebrian, R., Carnero, A., Pérez-Padrón, F., Byrne, David N., Blackmer, Jacquelyn L., Rathman, Robin J., Kasterstein), Esther Weisz, Fasulo, Thomas R., Riley, D. G., Allen, J. C., Brewster, C. C., Paris, J. F., Summers, C. G., Riley, D. G., Naranjo, S. E., Ellsworth, P. C., Diehl, J., Dennehy, T., Flint, H., Carnerol, A., González-Andujar, J. L., Peterling, O., Helman, S., Rumei, Xu, Legg, J., Fishpool, L., Natwick, E. T., Toscano, N. C., Yates, L., Hendrix, Donald L., Steele, Terry, Bar, H., Weinberg, A., Mor, U., Oetting, Donald D., Schuster, David J., Stansly, Philip A., Shapiro, Jeffrey P., Duffus, James E., Harris, K., Esbroeck, Z. Pesic-Van, Hiebert, E., Abouzid, A., Polston, J. E., Liu, S., Pinner, M., Briddon, R. W., Brown, J. K., Bird, J., Wyatt, S. D., Antignus, Y., Adler, O., Perlsman, Melanie, Joseph, Rachel Ben, Cohen, S., Serra, C., Conception, S., Polston, J., Ortiz, M., Benoit, P., Klaassen, Vicki A., Boeshore, Maury, Koonin, Eugene V., Tian, Tongyan, Falk, Bryce W., Cohen, J., Gera, A., Ecker, R., Gokkes, M., Fauquet, Claude M., Sangare, Abdourahamane, Deng, Dalun, Fux, Charles, Beachy, Roger N., Scott, J. W., Schuster, D. J., Barten, J. H. M., Stevens, M. R., Thome, C. H., Chambliss, O. L., Muniyappa, V., Nateshan, H. M., Jalikop, S. H., Chennarayappa, Ramappa, H. K., Raccah, B., Cheek, S., Nordlund, Donald A., Legaspi, Jesusa C., Dean, D. E., Schelt, J. van, Meyerdirk, D. E., Hennessey, R. D., Wendel, L., Goolsby, John, Ciomperlik, Matt, Vecek, Don, Kirk, A. A., Lacey, L. A., Heinz, K. M., Contreras, M., Hoelmer, K. A., Brasch, Klara, Henter, Heather, Minkenberg, Oscar, Kaltenbach, John, Leonard, Catie, Malloy, Richard, Simmons, Gregory, Ziegweid, Katie, Rose, M., Zolnerowich, G., Hunter, M. S., Oster, Noga, Arno, Judit, Gabarra, Rosa, Steinberg, S., Prag, H., Carruthers, R., Fransen, J. J., Barash, I., Mor, H., Gindin, G., Ben-Ze’ev, I., Ben-Ze’ev, I. S., Peterkin, Dorothy D., Hall, Richard A., Horowitz, A. R., Ishaaya, I., Denholm, I., Cahill, M. R., Byrne, F. J., Devonshire, A. L., Henneberry, T. J., Castle, N. Prabhaker, Castle, S., Anthony, N. M., Constant, R. H. ffrench, Sachs, Y., Fehmy, M., Hegab, A. H., Moawad, G. M., Nichols, R. L., Chu, C. C., Watson, T. F., Davidson, Elizabeth W., Patron, Rufino B. R., Mitich, Dusan, Stansly, P. A., Liu, T. X., Veierov, D., Aharonson, N., Eliyahu, Miriam, Fenigstein, Annie, Kletter, E., Munthali, D. C., Berlinger, M. J., Mordechi, Sarah Lebiush, Ausher, Reuben, Diehl, J. W., Husman, S. H., Kravchenko, Vasilyi, Arnal, Eustaquio, Ramos, Fidel, Fridja, Devorah, Ferrentino, G. W., Caballero, R., Nicholson, W. F., Senn, R., Fluckiger, C. R., Puri, S. N., Bhosle, B. B., Fartade, M. K., Kolhal, R. N., Butler, G. D., and Gupta, G. P.

Published
1994
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26. Cognitive behavioral therapy for menopausal symptoms.

Author

Hunter, M. S.

Subjects
*COGNITIVE therapy, *HOT flashes, *ANXIETY treatment, *ELECTRONIC books, *BREAST cancer, *SELF-help materials
Abstract

This article describes cognitive behavioral therapy (CBT) for women with problematic menopausal symptoms, and provides the evidence from clinical trials of women going through the menopause, women with breast cancer treatment-induced symptoms and women with problematic symptoms in a work context. The CBT focus is primarily on vasomotor symptoms (VMS) but it also targets stress, low mood and sleep problems. CBT is a brief therapy (four to six sessions) that is theory- and evidence-based; it is acceptable to women and effectively reduces the impact of VMS, improves sleep and has benefits to quality of life. VMS frequency is also reduced significantly in some trials but not others. CBT has been found to be consistently effective when delivered in groups, self-help book and on-line formats (with or without additional support). The MENOS 1 and MENOS 2 CBT protocols are recommended for the treatment of VMS by the North American Menopause Society (2015); CBT has been recommended for the treatment of anxiety and depression for women during the menopause transition and post menopause (NICE, 2015); and telephone CBT has been shown to be an effective treatment for insomnia. [ABSTRACT FROM AUTHOR]

Published
2021
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27. Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer : An individual patient data meta-analysis of 22 RCTs

Author

Kalter, J., Verdonck-de Leeuw, I. M., Sweegers, M. G., Aaronson, N. K., Jacobsen, P. B., Newton, R. U., Courneya, K. S., Aitken, J. F., Armes, J., Arving, Cecilia, Boersma, L. J., Braamse, A. M. J., Brandberg, Y., Chambers, S. K., Dekker, J., Ell, K., Ferguson, R. J., Gielissen, M. F. M., Glimelius, Bengt, Goedendorp, M. M., Graves, K. D., Heiney, S. P., Horne, R., Hunter, M. S., Johansson, Birgitta, Kimman, M. L., Knoop, H., Meneses, K., Northouse, L. L., Oldenburg, H. S., Prins, J. B., Savard, J., van Beurden, M., van den Berg, S. W., Brug, J., Buffart, L. M., Kalter, J., Verdonck-de Leeuw, I. M., Sweegers, M. G., Aaronson, N. K., Jacobsen, P. B., Newton, R. U., Courneya, K. S., Aitken, J. F., Armes, J., Arving, Cecilia, Boersma, L. J., Braamse, A. M. J., Brandberg, Y., Chambers, S. K., Dekker, J., Ell, K., Ferguson, R. J., Gielissen, M. F. M., Glimelius, Bengt, Goedendorp, M. M., Graves, K. D., Heiney, S. P., Horne, R., Hunter, M. S., Johansson, Birgitta, Kimman, M. L., Knoop, H., Meneses, K., Northouse, L. L., Oldenburg, H. S., Prins, J. B., Savard, J., van Beurden, M., van den Berg, S. W., Brug, J., and Buffart, L. M.

Abstract

Objective: This individual patient data (IPD) meta-analysis aimed to evaluate the effects of psychosocial interventions (PSI) on quality of life (QoL), emotional function (EF), and social function (SF) in patients with cancer, and to study moderator effects of demographic, clinical, personal, and intervention-related characteristics. Methods: Relevant studies were identified via literature searches in 4 databases. We pooled IPD from 22 (n = 4217) of 61 eligible randomized controlled trials. Linear mixed-effect model analyses were used to study intervention effects on the post-intervention values of QoL, EF, and SF (z-scores), adjusting for baseline values, age, and cancer type. We studied moderator effects by testing interactions with the intervention for demographic, clinical, personal, and intervention-related characteristics, and conducted subsequent stratified analyses for significant moderator variables.Results: PSI significantly improved QoL (=0.14,95%CI=0.06;0.21), EF ( beta = 0.13,95%CI = 0.05;0.20), and SF (beta = 0.10,95%CI = 0.03;0.18). Significant differences in effects of different types of PSI were found, with largest effects of psychotherapy. The effects of coping skills training were moderated by age, treatment type, and targeted interventions. Effects of psychotherapy on EF may be moderated by cancer type, but these analyses were based on 2 randomized controlled trials with small sample sizes of some cancer types. Conclusions: PSI significantly improved QoL, EF, and SF, with small overall effects. However, the effects differed by several demographic, clinical, personal, and intervention-related characteristics. Our study highlights the beneficial effects of coping skills training in patients treated with chemotherapy, the importance of targeted interventions, and the need of developing interventions tailored to the specific needs of elderly patients.

Published
2018
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28. Prevalence and predictors of complementary and alternative medicine/non-pharmacological interventions use for menopausal symptoms within the UK Collaborative Trial of Ovarian Cancer Screening

Author

Gentry-maharaj, A., Karpinskyj, C., Glazer, C., Burnell, M., Bailey, K., Apostolidou, S., Ryan, A., Lanceley, A., Fraser, L., Jacobs, I., Hunter, M. S., and Menon, U.

Subjects
Complementary Therapies, Ovarian Neoplasms, Menopausal symptoms, CAM, Estrogen Replacement Therapy, prevalence, Middle Aged, Article, State Medicine, United Kingdom, non-pharmacological interventions, Predictive Value of Tests, Surveys and Questionnaires, Hot Flashes, Humans, Mass Screening, Original Article, Female, UKCTOCS, NPI, Menopause, Aged, complementary and alternative medicine
Abstract

Objectives: The negative publicity about menopausal hormone therapy (MHT) has led to increased use of complementary and alternative medicines (CAM) and non-pharmacological interventions (NPI) for menopausal symptom relief. We report on the prevalence and predictors of CAM/NPI among UK postmenopausal women. Method: Postmenopausal women aged 50–74 years were invited to participate in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). A total of 202 638 women were recruited and completed a baseline questionnaire. Of these, 136 020 were sent a postal follow-up-questionnaire between September 2006 and May 2009 which included ever-use of CAM/NPI for menopausal symptom relief. Both questionnaires included MHT use. Results: A total of 88 430 (65.0%) women returned a completed follow-up-questionnaire; 22 206 (25.1%) reported ever-use of one or more CAM/NPI. Highest use was reported for herbal therapies (43.8%; 9725/22 206), vitamins (42.6%; 9458/22 206), lifestyle approaches (32.1%; 7137/22 206) and phytoestrogens (21.6%; 4802/22 206). Older women reported less ever-use of herbal therapies, vitamins and phytoestrogens. Lifestyle approaches, aromatherapy/reflexology/acupuncture and homeopathy were similar across age groups. Higher education, Black ethnicity, MHT or previous oral contraceptive pill use were associated with higher CAM/NPI use. Women assessed as being less hopeful about their future were less likely to use CAM/NPI. Conclusion: One in four postmenopausal women reported ever-use of CAM therapies/NPI for menopausal symptom relief, with lower use reported by older women. Higher levels of education and previous MHT use were positive predictors of CAM/NPI use. UKCTOCS Trial registration: ISRCTN22488978

Published
2017

29. Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review.

Author

Iliodromiti, S, Wang, W, Lumsden, MA, Hunter, MS, Bell, R, Mishra, G, Hickey, M, Lumsden, M A, and Hunter, M S

Subjects
HOT flashes, META-analysis, CLINICAL trials, METADATA
Abstract

Background: There is substantial variation in how menopausal vasomotor symptoms are reported and measured among intervention studies. This has prevented meaningful comparisons between treatments and limited data synthesis.Objectives: To review systematically the outcome reporting and measures used to assess menopausal vasomotor symptoms from randomised controlled trials of treatments.Search Strategy: We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials from inception to May 2018.Selection Criteria: Randomised controlled trials with a primary outcome of menopausal vasomotor symptoms in women and a sample size of at least 20 women per study arm.Data Collection and Analysis: Data about study characteristics, primary vasomotor-related outcomes and methods of measuring them.Main Results: The search identified 5591 studies, 214 of which were included. Forty-nine different primary reported outcomes were identified for vasomotor symptoms and 16 different tools had been used to measure these outcomes. The most commonly reported outcomes were frequency (97/214), severity (116/214), and intensity (28/114) of vasomotor symptoms or a composite of these outcomes (68/214). There was little consistency in how the frequency and severity/intensity of vasomotor symptoms were defined.Conclusions: There is substantial variation in how menopausal vasomotor symptoms have been reported and measured in treatment trials. Future studies should include standardised outcome measures which reflect the priorities of patients, clinicians, and researchers. This is most effectively achieved through the development of a Core Outcome Set. This systematic review is the first step towards development of a Core Outcome Set for menopausal vasomotor symptoms.Tweetable Summary: Menopausal hot flushes and night sweats have been reported in 49 different ways in clinical research. A core outcome set is urgently required. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

Author

Stagno, J. R., primary, Liu, Y., additional, Bhandari, Y. R., additional, Conrad, C. E., additional, Panja, S., additional, Swain, M., additional, Fan, L., additional, Nelson, G., additional, Li, C., additional, Wendel, D. R., additional, White, T. A., additional, Coe, J. D., additional, Wiedorn, M. O., additional, Knoska, J., additional, Oberthuer, D., additional, Tuckey, R. A., additional, Yu, P., additional, Dyba, M., additional, Tarasov, S. G., additional, Weierstall, U., additional, Grant, T. D., additional, Schwieters, C. D., additional, Zhang, J., additional, Ferré-D'Amaré, A. R., additional, Fromme, P., additional, Draper, D. E., additional, Liang, M., additional, Hunter, M. S., additional, Boutet, S., additional, Tan, K., additional, Zuo, X., additional, Ji, X., additional, Barty, A., additional, Zatsepin, N. A., additional, Chapman, H. N., additional, Spence, J. C. H., additional, Woodson, S. A., additional, and Wang, Y.-X., additional

Published
2017
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33. The menopausal hot flush: a review

Author

Sturdee, D. W., primary, Hunter, M. S., additional, Maki, P. M., additional, Gupta, P., additional, Sassarini, J., additional, Stevenson, J. C., additional, and Lumsden, M. A., additional

Published
2017
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35. Prevalence and predictors of complementary and alternative medicine/non-pharmacological interventions use for menopausal symptoms within the UK Collaborative Trial of Ovarian Cancer Screening

Author

Gentry-Maharaj, A., primary, Karpinskyj, C., additional, Glazer, C., additional, Burnell, M., additional, Bailey, K., additional, Apostolidou, S., additional, Ryan, A., additional, Lanceley, A., additional, Fraser, L., additional, Jacobs, I., additional, Hunter, M. S., additional, and Menon, U., additional

Published
2017
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37. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

Author

Stagno, J. R., primary, Liu, Y., additional, Bhandari, Y. R., additional, Conrad, C. E., additional, Panja, S., additional, Swain, M., additional, Fan, L., additional, Nelson, G., additional, Li, C., additional, Wendel, D. R., additional, White, T. A., additional, Coe, J. D., additional, Wiedorn, M. O., additional, Knoska, J., additional, Oberthuer, D., additional, Tuckey, R. A., additional, Yu, P., additional, Dyba, M., additional, Tarasov, S. G., additional, Weierstall, U., additional, Grant, T. D., additional, Schwieters, C. D., additional, Zhang, J., additional, Ferré-D’Amaré, A. R., additional, Fromme, P., additional, Draper, D. E., additional, Liang, M., additional, Hunter, M. S., additional, Boutet, S., additional, Tan, K., additional, Zuo, X., additional, Ji, X., additional, Barty, A., additional, Zatsepin, N. A., additional, Chapman, H. N., additional, Spence, J. C. H., additional, Woodson, S. A., additional, and Wang, Y.-X., additional

Published
2016
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43. Men’s experience of a guided self-help intervention for hot flushes associated with prostate cancer treatment.

Author

Grunfeld, E. A., Hunter, M. S., and Yousaf, O.

Subjects
*MENTAL health, *QUALITY of life, *PREVENTION of psychological stress, *HOT flashes, *PSYCHOLOGICAL adaptation, *BEHAVIOR modification, *ANTIANDROGENS, *COGNITIVE therapy, *EXPERIENCE, *HEALTH behavior, *INTERVIEWING, *LONGITUDINAL method, *RESEARCH methodology, *PROSTATE tumors, *RELAXATION for health, *RESEARCH funding, *HEALTH self-care, *THEMATIC analysis, *TREATMENT effectiveness, *MEDICAL coding, *DESCRIPTIVE statistics, *PSYCHOEDUCATION, *PSYCHOLOGY, *THERAPEUTICS
Abstract

Up to 80% of men who receive androgen deprivation therapy report hot flushes and for many these are associated with reduced quality of life. However it is recognised that there are a number of barriers to men's engagement with support to manage symptoms and improve quality of life. This qualitative study was embedded within a larger randomised controlled trial (MANCAN) of a guided self-help cognitive behavioural intervention to manage hot flushes resulting among men receiving androgen deprivation therapy. The study aimed to explore the engagement and experiences with the guided self-help intervention. Twenty men recruited from the treatment arm of the MANCAN trial participated in a semi-structured interview exploring acceptability of the intervention, factors affecting engagement and perceived usefulness of the intervention. Interviews were audio-recorded, transcribed verbatim and analysed using a Framework approach. Over two thirds of respondents (69%) reported reading the intervention booklet in full and over 90% reporting practising the relaxation CD at least once a week. Analysis of the interviews identified three super-ordinate themes and these related to changes in hot flush symptomatology (learned to cope with hot flushes in new ways), the skills that participants had derived from the intervention (promoting relaxation and reducing stressors), and to a broader usefulness of the intervention (broader impact of the intervention and skills). The present study identified positive engagement with a guided self-help intervention and that men applied the skills developed through the intervention to help them undertake general lifestyle changes. Psycho-educational interventions (e.g. cognitive behaviour therapy, relaxation, and positive lifestyle elements) offer the potential to be both effective and well received by male cancer survivors. [ABSTRACT FROM AUTHOR]

Published
2017
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49. Mesoscale morphology of airborne core-shell nanoparticle clusters : x-ray laser coherent diffraction imaging

Author

Pedersoli, E., Loh, N. D., Capotondi, F., Hampton, C. Y., Sierra, R. G., Starodub, D., Bostedt, C., Bozek, J., Nelson, A. J., Aslam, M., Li, S., Dravid, V. P., Martin, A. V., Aquila, A., Barty, A., Fleckenstein, H., Gumprecht, L., Liang, M., Nass, K., Schulz, J., White, T. A., Coppola, N., Bajt, S., Barthelmess, M., Graafsma, H., Hirsemann, H., Wunderer, C., Epp, S. W., Erk, B., Rudek, B., Rudenko, A., Foucar, L., Kassemeyer, S., Lomb, L., Rolles, D., Shoeman, R. L., Steinbrener, J., Hartmann, R., Hartmann, A., Hauser, G., Holl, P., Kimmel, N., Reich, C., Soltau, H., Weidenspointner, G., Benner, W. H., Farquar, G. R., Hau-Riege, S. P., Hunter, M. S., Ekeberg, Tomas, Hantke, Max, Maia, Filipe R. N. C., Tobias, H. J., Marchesini, S., Frank, M., Strueder, L., Schlichting, I., Ullrich, J., Chapman, H. N., Bucksbaum, P. H., Kiskinova, M., Bogan, M. J., Pedersoli, E., Loh, N. D., Capotondi, F., Hampton, C. Y., Sierra, R. G., Starodub, D., Bostedt, C., Bozek, J., Nelson, A. J., Aslam, M., Li, S., Dravid, V. P., Martin, A. V., Aquila, A., Barty, A., Fleckenstein, H., Gumprecht, L., Liang, M., Nass, K., Schulz, J., White, T. A., Coppola, N., Bajt, S., Barthelmess, M., Graafsma, H., Hirsemann, H., Wunderer, C., Epp, S. W., Erk, B., Rudek, B., Rudenko, A., Foucar, L., Kassemeyer, S., Lomb, L., Rolles, D., Shoeman, R. L., Steinbrener, J., Hartmann, R., Hartmann, A., Hauser, G., Holl, P., Kimmel, N., Reich, C., Soltau, H., Weidenspointner, G., Benner, W. H., Farquar, G. R., Hau-Riege, S. P., Hunter, M. S., Ekeberg, Tomas, Hantke, Max, Maia, Filipe R. N. C., Tobias, H. J., Marchesini, S., Frank, M., Strueder, L., Schlichting, I., Ullrich, J., Chapman, H. N., Bucksbaum, P. H., Kiskinova, M., and Bogan, M. J.

Abstract

Unraveling the complex morphology of functional materials like core-shell nanoparticles and its evolution in different environments is still a challenge. Only recently has the single-particle coherent diffraction imaging (CDI), enabled by the ultrabright femtosecond free-electron laser pulses, provided breakthroughs in understanding mesoscopic morphology of nanoparticulate matter. Here, we report the first CDI results for Co@SiO2 core-shell nanoparticles randomly clustered in large airborne aggregates, obtained using the x-ray free-electron laser at the Linac Coherent Light Source. Our experimental results compare favourably with simulated diffraction patterns for clustered Co@SiO2 nanoparticles with similar to 10 nm core diameter and similar to 30 nm shell outer diameter, which confirms the ability to resolve the mesoscale morphology of complex metastable structures. The findings in this first morphological study of core-shell nanomaterials are a solid base for future time-resolved studies of dynamic phenomena in complex nanoparticulate matter using x-ray lasers.

Published
2013
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50. Profiling structured beams using injected aerosols

Author

Duane Loh, N., Starodub, D., Lomb, L., Hampton, C. Y., Martin, A. V., Sierra, R. G., Barty, A., Aquila, A., Schulz, J., Steinbrener, J., Shoeman, R. L., Kassemeyer, S., Bostedt, C., Bozek, J., Epp, S. W., Erk, B., Hartmann, R., Rolles, D., Rudenko, A., Rudek, B., Foucar, L., Kimmel, N., Weidenspointner, G., Hauser, G., Holl, P., Pedersoli, E., Liang, M., Hunter, M. S., Gumprecht, L., Coppola, N., Wunderer, C., Graafsma, H., Maia, F. R. N. C., Ekeberg, T., Hantke, Max Felix, Fleckenstein, H., Hirsemann, H., Nass, K., White, T. A., Tobias, H. J., Farquar, G. R., Henry Benner, W., Hau-Riege, S., Reich, C., Hartmann, A., Soltau, H., Marchesini, S., Bajt, S., Barthelmess, M., Strueder, L., Ullrich, J., Bucksbaum, P., Hodgson, K. O., Frank, M., Schlichting, I., Chapman, H. N., Bogan, M. J., Duane Loh, N., Starodub, D., Lomb, L., Hampton, C. Y., Martin, A. V., Sierra, R. G., Barty, A., Aquila, A., Schulz, J., Steinbrener, J., Shoeman, R. L., Kassemeyer, S., Bostedt, C., Bozek, J., Epp, S. W., Erk, B., Hartmann, R., Rolles, D., Rudenko, A., Rudek, B., Foucar, L., Kimmel, N., Weidenspointner, G., Hauser, G., Holl, P., Pedersoli, E., Liang, M., Hunter, M. S., Gumprecht, L., Coppola, N., Wunderer, C., Graafsma, H., Maia, F. R. N. C., Ekeberg, T., Hantke, Max Felix, Fleckenstein, H., Hirsemann, H., Nass, K., White, T. A., Tobias, H. J., Farquar, G. R., Henry Benner, W., Hau-Riege, S., Reich, C., Hartmann, A., Soltau, H., Marchesini, S., Bajt, S., Barthelmess, M., Strueder, L., Ullrich, J., Bucksbaum, P., Hodgson, K. O., Frank, M., Schlichting, I., Chapman, H. N., and Bogan, M. J.

Abstract

Profiling structured beams produced by X-ray free-electron lasers (FELs) is crucial to both maximizing signal intensity for weakly scattering targets and interpreting their scattering patterns. Earlier ablative imprint studies describe how to infer the X-ray beam profile from the damage that an attenuated beam inflicts on a substrate. However, the beams in-situ profile is not directly accessible with imprint studies because the damage profile could be different from the actual beam profile. On the other hand, although a Shack-Hartmann sensor is capable of in-situ profiling, its lenses may be quickly damaged at the intense focus of hard X-ray FEL beams. We describe a new approach that probes the in-situ morphology of the intense FEL focus. By studying the translations in diffraction patterns from an ensemble of randomly injected sub-micron latex spheres, we were able to determine the non-Gaussian nature of the intense FEL beam at the Linac Coherent Light Source (SLAC National Laboratory) near the FEL focus. We discuss an experimental application of such a beam-profiling technique, and the limitations we need to overcome before it can be widely applied.

Published
2012
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