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Your search keyword '"Hunter, Arwen L."' showing total 13 results
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13 results on '"Hunter, Arwen L."'

10. Granzyme B Induces Smooth Muscle Cell Apoptosis in the Absence of Perforin

Author

Choy, Jonathan C., primary, Hung, Vivian H.Y., additional, Hunter, Arwen L., additional, Cheung, Paul K., additional, Motyka, Bruce, additional, Goping, Ing Swie, additional, Sawchuk, Tracy, additional, Bleackley, R. Chris, additional, Podor, Thomas J., additional, McManus, Bruce M., additional, and Granville, David J., additional

Published
2004
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12. Detection of Apoptosis in Cardiovascular Diseases.

Author

Walker, John M., Sun, Zhongjie, Hunter, Arwen L., Choy, Jonathan C., and Granville, David J.

Abstract

The past decade has seen a surge in research devoted to understanding the role of cell death in the pathogenesis of various forms of cardiovascular disease. In particular, apoptosis has received much attention owing to the tightly regulated biochemical nature of this form of cell death and the realization of potential therapeutic opportunities. The current chapter describes a few of the more widely used protocols for detecting and quantifying apoptosis in cardiovascular tissues. Specifically, this chapter describes terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining for DNA fragmentation, Hoechst staining for chromatin condensation, annexin V labeling of phosphatidylserine externalization, and Western blot and immunoflorescence detection of caspase cleavage and activation, respectively. [ABSTRACT FROM AUTHOR]

Published
2005
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13. Detection of apoptosis in cardiovascular diseases.

Author

Hunter AL, Choy JC, and Granville DJ

Subjects
Animals, Annexin A5 metabolism, Cardiovascular Diseases metabolism, Cardiovascular Diseases pathology, Caspases analysis, Cell Death, Cells, Cultured, DNA Fragmentation, Endothelium, Vascular cytology, Endothelium, Vascular metabolism, Humans, In Situ Nick-End Labeling, Mitochondria, Heart metabolism, Muscle, Smooth, Vascular, Myocytes, Cardiac cytology, Myocytes, Cardiac metabolism, Staining and Labeling, Apoptosis, Cardiovascular Diseases physiopathology
Abstract

The past decade has seen a surge in research devoted to understanding the role of cell death in the pathogenesis of various forms of cardiovascular disease. In particular, apoptosis has received much attention owing to the tightly regulated biochemical nature of this form of cell death and the realization of potential therapeutic opportunities. The current chapter describes a few of the more widely used protocols for detecting and quantifying apoptosis in cardiovascular tissues. Specifically, this chapter describes terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining for DNA fragmentation, Hoechst staining for chromatin condensation, annexin V labeling of phosphatidylserine externalization, and Western blot and immunoflorescence detection of caspase cleavage and activation, respectively.

Published
2005
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