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1,857 results on '"Hunt, Andrew"'

4. Chemical Reaction Dynamics under Vibrational Strong Coupling

Author

Hunt, Andrew C.

Subjects
Physics - Chemical Physics, Quantum Physics
Abstract

In this thesis, we use classical, semi-classical and quantum-mechanical methods to simulate chemical reaction dynamics inside of an optical cavity. Within such a cavity, by selectively coupling vibrational modes of the reactants to the vacuum state of light, recent experiments have observed significant changes in reaction rates and equilibrium constants - all without any external input of energy. We investigate the dynamics of both a single reaction and an ensemble of N identical reactions coupled to the cavity. In our single reactant studies, we find significant modification to the rate of reaction and to its quantum-mechanical equilibrium constant. All of the effects observed in our single molecule studies are however found to diminish as the number of reactants is increased. For any experimentally relevant number of molecules, the cavity effects on the reaction rate and the equilibrium constant are therefore shown to be negligible within all theories considered in this thesis. This thesis therefore does not offer any explanation for the experimental observations. It does however highlight issues with all current theoretical work on this topic, and provides suggestions - in light of the results presented here and in recent literature - as to what might be required to explain these effects., Comment: undergrad thesis

Published
2024

12. Cover

Author

Hunt, Andrew

Published
2006

13. Notes

Author

Hunt, Andrew

Published
2006

21. Index

Author

Hunt, Andrew

Published
2006

26. Thermal quenching of classical and semiclassical scrambling

Author

Sadhasivam, Vijay Ganesh, Hunt, Andrew C., Meuser, Lars, Litman, Yair, and Althorpe, Stuart C.

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

Quantum scrambling often gives rise to short-time exponential growth in out-of-time-ordered correlators (OTOCs). The scrambling rate over an isolated saddle point at finite temperature is shown here to be reduced by a hierarchy of quenching processes. Two of these appear in the classical limit, where escape from the neighbourhood of the saddle reduces the rate by a factor of two, and thermal fluctuations around the saddle reduce it further; a third process can be explained semiclassically as arising from quantum thermal fluctuations around the saddle, which are also responsible for imposing the Maldacena-Shenker-Stanford bound.

Published
2023

27. Index

Author

Hunt, Andrew

Published
1999

34. Notes

Author

Hunt, Andrew

Published
1999

40. Cover

Author

Hunt, Andrew

Published
1999

42. Medication-Assisted Psychotherapy: The Past and Future of Psychiatry

Author

Malidelis, Ioannis Alex, Hunt, Andrew, and Aftab, Awais

Subjects
Medical colleges, Amobarbital, Clinical psychiatry, Neurophysiology, Health, Psychology and mental health
Abstract

Psychiatric practice has increasingly relied on medication management rather than psychotherapy as a mainstay of treatment over the past few decades, despite the general recognition that pharmacology alone is insufficient [...]

Published
2024

48. Land-use interactions, Oil-Field infrastructure, and natural processes control hydrocarbon and arsenic concentrations in groundwater, Poso Creek Oil Field, California, USA

Author

McMahon, Peter B., Landon, Matthew K., Stephens, Michael J., Taylor, Kim A., Wright, Michael T., Hansen, Angela M., Kraus, Tamara E.C., Cozzarelli, Isabelle M., Shimabukuro, David H., Sowers, Theron A., Kulongoski, Justin T., Hunt, Andrew G., Karolytė, Ruta, Hillegonds, Darren J., and Ballentine, Chris J.

Published
2024
Full Text
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50. Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

Author

Hunt, Andrew C, Case, James Brett, Park, Young-Jun, Cao, Longxing, Wu, Kejia, Walls, Alexandra C, Liu, Zhuoming, Bowen, John E, Yeh, Hsien-Wei, Saini, Shally, Helms, Louisa, Zhao, Yan Ting, Hsiang, Tien-Ying, Starr, Tyler N, Goreshnik, Inna, Kozodoy, Lisa, Carter, Lauren, Ravichandran, Rashmi, Green, Lydia B, Matochko, Wadim L, Thomson, Christy A, Vögeli, Bastian, Krüger, Antje, VanBlargan, Laura A, Chen, Rita E, Ying, Baoling, Bailey, Adam L, Kafai, Natasha M, Boyken, Scott E, Ljubetič, Ajasja, Edman, Natasha, Ueda, George, Chow, Cameron M, Johnson, Max, Addetia, Amin, Navarro, Mary Jane, Panpradist, Nuttada, Gale, Michael, Freedman, Benjamin S, Bloom, Jesse D, Ruohola-Baker, Hannele, Whelan, Sean PJ, Stewart, Lance, Diamond, Michael S, Veesler, David, Jewett, Michael C, and Baker, David

Subjects
Medical Biotechnology, Engineering, Biomedical and Clinical Sciences, Biomedical Engineering, Vaccine Related, Lung, Emerging Infectious Diseases, Biodefense, Pneumonia, Autoimmune Disease, Infectious Diseases, Pneumonia & Influenza, Prevention, Biotechnology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Animals, Antibodies, Neutralizing, Antibodies, Viral, COVID-19, Cryoelectron Microscopy, Humans, Mice, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Biological Sciences, Medical and Health Sciences, Medical biotechnology, Biomedical engineering
Abstract

New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a cell-free expression workflow to rapidly screen and optimize constructs containing multiple computationally designed miniprotein inhibitors of SARS-CoV-2. We found the broadest efficacy was achieved with a homotrimeric version of the 75-residue angiotensin-converting enzyme 2 (ACE2) mimic AHB2 (TRI2-2) designed to geometrically match the trimeric spike architecture. Consistent with the design model, in the cryo-electron microscopy structure TRI2-2 forms a tripod at the apex of the spike protein that engaged all three receptor binding domains simultaneously. TRI2-2 neutralized Omicron (B.1.1.529), Delta (B.1.617.2), and all other variants tested with greater potency than the monoclonal antibodies used clinically for the treatment of COVID-19. TRI2-2 also conferred prophylactic and therapeutic protection against SARS-CoV-2 challenge when administered intranasally in mice. Designed miniprotein receptor mimics geometrically arrayed to match pathogen receptor binding sites could be a widely applicable antiviral therapeutic strategy with advantages over antibodies in greater resistance to viral escape and antigenic drift, and advantages over native receptor traps in lower chances of autoimmune responses.

Published
2022

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