216 results on '"Hungate, Randall"'
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2. Stereoselective synthesis of anti-N-protected 3-amino-1,2-epoxides by nucleophilic addition to N-tert-butanesulfinyl imine of a glyceraldehyde synthon
3. An efficient and scalable one-pot double Michael addition-dieckmann condensation for the synthesis of 4,4-disubstituted cyclohexane [beta]-keto esters
4. The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase
5. Discovery and evaluation of 3-(5-Thien-3-ylpyridin-3-yl)-1H-indoles as a novel class of KDR kinase inhibitors
6. Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics
7. Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies
8. Rapid X-ray diffraction analysis of HIV-1 protease–inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme
9. Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN®
10. New cytochalasins: Synthetic studies of a novel HIV-1 protease inhibitor
11. Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency
12. Conformationally constrained HIV-1 protease inhibitors
13. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ*S–X) Interaction for Conformational Constraint
14. ChemInform Abstract: New Cytochalasins: Synthetic Studies of a Novel HIV-1 Protease Inhibitor
15. ChemInform Abstract: Aromatic P1 Replacements for the Highly Potent HIV-1 Protease Inhibitor Crixivan
16. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2
17. Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit
18. 3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation
19. Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors
20. Aryl sulfonamides containing tetralin allylic amines as potent and selective bradykinin B1 receptor antagonists
21. Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines
22. Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists
23. Azole-based inhibitors of AKT/PKB for the treatment of cancer
24. 2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics
25. Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease
26. Discovery of Clinical Candidate 1-(4-(3-(4-(1H-Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)
27. Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR
28. Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors
29. Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11β-HSD1 inhibitors
30. Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors
31. Aryl sulfones as novel Bradykinin B1 receptor antagonists for treatment of chronic pain
32. Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors
33. Discovery of amido-benzisoxazoles as potent c-Kit inhibitors
34. Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists
35. Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation
36. Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases
37. Discovery of potent LPA 2 (EDG4) antagonists as potential anticancer agents
38. Synthesis, antiviral activity, and bioavailability studies of gamma-lactam derived HIV protease inhibitors
39. Dipeptidyl-Quinolone Derivatives Inhibit Hypoxia Inducible Factor-1α Prolyl Hydroxylases-1, -2, and -3 with Altered Selectivity
40. Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
41. ChemInform Abstract: Stereoselective Synthesis of anti‐N‐Protected 3‐Amino‐1,2‐epoxides by Nucleophilic Addition to N‐tert‐Butanesulfinyl Imine of a Glyceraldehyde Synthon.
42. Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2−Tumor Protein 53 Protein−Protein Interaction
43. Stereoselective Synthesis ofanti-N-Protected 3-Amino-1,2-epoxides by Nucleophilic Addition toN-tert-Butanesulfinyl Imine of a Glyceraldehyde Synthon†
44. New ‘chemical probes’ to examine the role of the hFPRL1 (or ALXR) receptor in inflammation
45. The discovery of 2-anilinothiazolones as 11β-HSD1 inhibitors
46. An efficient synthesis of 1,6- and 1,7-dibromo-3-aminoisoquinolines: versatile templates for the preparation of functionalized isoquinolines
47. Further Studies with the 2-Amino-1,3-thiazol-4(5H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in a Monkey Pharmacodynamic Model
48. Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors
49. Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model▽
50. Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit
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