17 results on '"Hung TN"'
Search Results
2. Global spread of norovirus gii.17 kawasaki 308, 2014–2016
- Author
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Chan, MCW, Hu, Y, Chen, H, Podkolzin, AT, Zaytseva, EV, Komano, J, Sakon, N, Poovorawan, Y, Vongpunsawad, S, Thanusuwannasak, T, Hewitt, J, Croucher, D, Collins, N, Vinjé, J, Pang, XL, Lee, BE, De Graaf, M, Van Beek, J, Vennema, H, Koopmans, MPG, Niendorf, S, Poljsak-Prijatelj, M, Steyer, A, White, PA, Lun, JH, Mans, J, Hung, TN, Kwok, K, Cheung, K, Lee, N, Chan, PKS, Chan, MCW, Hu, Y, Chen, H, Podkolzin, AT, Zaytseva, EV, Komano, J, Sakon, N, Poovorawan, Y, Vongpunsawad, S, Thanusuwannasak, T, Hewitt, J, Croucher, D, Collins, N, Vinjé, J, Pang, XL, Lee, BE, De Graaf, M, Van Beek, J, Vennema, H, Koopmans, MPG, Niendorf, S, Poljsak-Prijatelj, M, Steyer, A, White, PA, Lun, JH, Mans, J, Hung, TN, Kwok, K, Cheung, K, Lee, N, and Chan, PKS
- Abstract
Analysis of complete capsid sequences of the emerging norovirus GII.17 Kawasaki 308 from 13 countries demonstrated that they originated from a single haplotype since the initial emergence in China in late 2014. Global spread of a sublineage SL2 was identified. A new sublineage SL3 emerged in China in 2016.
- Published
- 2017
3. Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes
- Author
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Nguyet, MN, Duong, THK, Trung, VT, Nguyen, THQ, Tran, CNB, Long, VT, Dui, LT, Hoa, LN, Farrar, JJ, Holmes, EC, Rabaa, MA, Bryant, JE, Truong, TN, Huong, TCN, Lan, THN, Mai, PP, Hung, TN, Tai, THL, Wills, B, Chau, VVN, Wolbers, M, Simmons, CP, Nguyet, MN, Duong, THK, Trung, VT, Nguyen, THQ, Tran, CNB, Long, VT, Dui, LT, Hoa, LN, Farrar, JJ, Holmes, EC, Rabaa, MA, Bryant, JE, Truong, TN, Huong, TCN, Lan, THN, Mai, PP, Hung, TN, Tai, THL, Wills, B, Chau, VVN, Wolbers, M, and Simmons, CP
- Abstract
Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50% mosquito infectious dose for each of DENV-1-4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission.
- Published
- 2013
4. The clinical characteristics of pediatric patients infected by SARS-CoV-2 Omicron variant and whole viral genome sequencing analysis.
- Author
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Tsang HF, Yu ACS, Yim AKY, Jin N, Wu YO, Cheng HYL, Cheung WL, Leung WMS, Lam KW, Hung TN, Chan L, Chiou J, Pei XM, Lee OYA, Cho WCS, and Wong SCC
- Subjects
- Adult, Humans, Child, Phylogeny, SARS-CoV-2, Genome, Viral, COVID-19
- Abstract
Pediatric population was generally less affected clinically by SARS-CoV-2 infection. Few pediatric cases of COVID-19 have been reported compared to those reported in infected adults. However, a rapid increase in the hospitalization rate of SARS-CoV-2 infected pediatric patients was observed during Omicron variant dominated COVID-19 outbreak. In this study, we analyzed the B.1.1.529 (Omicron) genome sequences collected from pediatric patients by whole viral genome amplicon sequencing using Illumina next generation sequencing platform, followed by phylogenetic analysis. The demographic, epidemiologic and clinical data of these pediatric patients are also reported in this study. Fever, cough, running nose, sore throat and vomiting were the more commonly reported symptoms in children infected by Omicron variant. A novel frameshift mutation was found in the ORF1b region (NSP12) of the genome of Omicron variant. Seven mutations were identified in the target regions of the WHO listed SARS-CoV-2 primers and probes. On protein level, eighty-three amino acid substitutions and fifteen amino acid deletions were identified. Our results indicate that asymptomatic infection and transmission among children infected by Omicron subvariants BA.2.2 and BA.2.10.1 are not common. Omicron may have different pathogenesis in pediatric population., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Tsang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2023
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5. Photocatalytic disinfection of Coliforms and degradation of natural organic matters in river water using titanate nanotubes.
- Author
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Nguyen NH, Tran Tien K, Hung TN, Vo Nguyen Xuan Q, Ho Thi T, Le Thi P, and Nguyen Thi T
- Subjects
- Adsorption, Catalysis, Disinfection, Rivers, Nanotubes chemistry, Titanium chemistry
- Abstract
In this study, we synthesized and modified titanate nanotubes (TNTs) under different conditions of acid rinsing and calcination. The produced materials were then characterized by transmission electron microscopy, X-ray diffraction, ultraviolet-visible spectroscopy, temperature programmed desorption, inductively coupled plasma atomic emission spectroscopy, and Brunauer-Emmett-Teller analysis. The activity of material was evaluated via its application for disinfection of Coliforms and removal of natural organic matters (NOMs) in river water. Results showed that TNTs rinsed at pH 1.6 and calcined at 500°C had the highest removal efficiency for the treatment of Coliforms and NOMs in Sai Gon river water, possibly due to its high surface area, crystallinity, and surface acidity. The application of this TNTs material for the treatment of waters from Dong Nai River and Mekong River also show high removal efficiency, which could meet the quality standard for supply water, suggesting the potential of TNTs for practical drinking water treatment.
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- 2022
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6. Oxidation of Cysteinate Anions Immobilized in the Interlamellar Space of CaAl-Layered Double Hydroxide.
- Author
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Timár Z, Hung TN, Pravda C, Kónya Z, Kukovecz Á, Sipos P, Varga G, and Pálinkó I
- Abstract
L-Cysteinate-intercalated CaAl-layered double hydroxide (LDH) was prepared by the co-precipitation method producing highly crystalline hydrocalumite phase with a well-pillared interlayer gallery. The obtained materials were characterized by X-ray diffractometry, IR as well as Raman spectroscopies. By performing interlamellar oxidation reactions with peracetic acid as oxidant, oxidation of cysteinate to cystinate in aqueous and cysteinate sulfenic acid in acetonic suspensions occurred. The oxidations could be performed under mild conditions, at room temperature, under neutral pH and in air. It has been shown that the transformation pathways are due to the presence of the layered structure, that is, the confined space of the LDH behaved as molecular reactor.
- Published
- 2021
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7. Increased Detection of Emergent Recombinant Norovirus GII.P16-GII.2 Strains in Young Adults, Hong Kong, China, 2016-2017.
- Author
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Kwok K, Niendorf S, Lee N, Hung TN, Chan LY, Jacobsen S, Nelson EAS, Leung TF, Lai RWM, Chan PKS, and Chan MCW
- Subjects
- Adolescent, Adult, Aged, Caliciviridae Infections epidemiology, Caliciviridae Infections virology, Child, Child, Preschool, Communicable Diseases, Emerging virology, Female, Gastroenteritis virology, Genotype, Hong Kong epidemiology, Humans, Infant, Male, Middle Aged, Norovirus isolation & purification, Phylogeny, Reassortant Viruses, Seasons, Young Adult, Communicable Diseases, Emerging epidemiology, Disease Outbreaks, Gastroenteritis epidemiology, Norovirus genetics
- Abstract
A new recombinant norovirus GII.P16-GII.2 outnumbered pandemic GII.4 as the predominant GII genotype in the winter of 2016-2017 in Hong Kong, China. Half of hospitalized case-patients were older children and adults, including 13 young adults. This emergent norovirus targets a wider age population compared with circulating pandemic GII.4 strains.
- Published
- 2017
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8. Global Spread of Norovirus GII.17 Kawasaki 308, 2014-2016.
- Author
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Chan MCW, Hu Y, Chen H, Podkolzin AT, Zaytseva EV, Komano J, Sakon N, Poovorawan Y, Vongpunsawad S, Thanusuwannasak T, Hewitt J, Croucher D, Collins N, Vinjé J, Pang XL, Lee BE, de Graaf M, van Beek J, Vennema H, Koopmans MPG, Niendorf S, Poljsak-Prijatelj M, Steyer A, White PA, Lun JH, Mans J, Hung TN, Kwok K, Cheung K, Lee N, and Chan PKS
- Subjects
- Caliciviridae Infections history, Caliciviridae Infections transmission, Capsid Proteins genetics, Cluster Analysis, Gastroenteritis history, Genotype, Global Health, History, 21st Century, Humans, Norovirus genetics, Phylogeny, Sequence Analysis, DNA, Caliciviridae Infections epidemiology, Caliciviridae Infections virology, Gastroenteritis epidemiology, Gastroenteritis virology, Norovirus classification
- Abstract
Analysis of complete capsid sequences of the emerging norovirus GII.17 Kawasaki 308 from 13 countries demonstrated that they originated from a single haplotype since the initial emergence in China in late 2014. Global spread of a sublineage SL2 was identified. A new sublineage SL3 emerged in China in 2016.
- Published
- 2017
- Full Text
- View/download PDF
9. IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1pdm09 Influenza.
- Author
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Lee N, Cao B, Ke C, Lu H, Hu Y, Tam CHT, Ma RCW, Guan D, Zhu Z, Li H, Lin M, Wong RYK, Yung IMH, Hung TN, Kwok K, Horby P, Hui DSC, Chan MCW, and Chan PKS
- Subjects
- Adult, Aged, Asian People, China epidemiology, Female, Gene Frequency, Genetic Predisposition to Disease, Genotyping Techniques, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H7N9 Subtype, Influenza, Human epidemiology, Male, Middle Aged, Polymorphism, Single Nucleotide, Proportional Hazards Models, CD55 Antigens genetics, Influenza, Human genetics, Membrane Proteins genetics, RNA-Binding Proteins genetics, Toll-Like Receptor 3 genetics
- Abstract
Background: We examined associations between single-nucleotide polymorphisms (SNPs) of IFITM3, TLR3, and CD55 genes and influenza clinical outcomes in Chinese., Methods: A multicenter study was conducted on 275 adult cases of avian (H7N9) and pandemic (H1N1pdm09) influenza. Host DNA was extracted from diagnostic respiratory samples; IFITM3 rs12252, TLR3 rs5743313, CD55 rs2564978, and TLR4 rs4986790/4986791 were targeted for genotyping (Sanger sequencing). The primary outcome analyzed was death., Results: IFITM3 and TLR3 SNPs were in Hardy-Weinberg equilibrium; their allele frequencies (IFITM3/C-allele 0.56, TLR3/C-allele 0.88) were comparable to 1000 Genomes Han Chinese data. We found over-representation of homozygous IFITM3 CC (54.5% vs 33.2%; P = .02) and TLR3 CC (93.3% vs 76.9%; P = .04) genotypes among fatal cases. Recessive genetic models showed their significant independent associations with higher death risks (adjusted hazard ratio [aHR] 2.78, 95% confidence interval [CI] 1.29-6.02, and aHR 4.85, 95% CI 1.11-21.06, respectively). Cumulative effects were found (aHR 3.53, 95% CI 1.64-7.59 per risk genotype; aHR 9.99, 95% CI 1.27-78.59 with both). Results were consistent for each influenza subtype and other severity indicators. The CD55 TT genotype was linked to severity. TLR4 was nonpolymorphic., Conclusions: Host genetic factors may influence clinical outcomes of avian and pandemic influenza infections. Such findings have important implications on disease burden and patient care in at-risk populations., (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
- Published
- 2017
- Full Text
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10. Complete Genome Sequence of an Emergent Recombinant GII.P16-GII.2 Norovirus Strain Associated with an Epidemic Spread in the Winter of 2016-2017 in Hong Kong, China.
- Author
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Chan MCW, Kwok K, Hung TN, Chan LY, and Chan PKS
- Abstract
A new recombinant norovirus, GII.P16-GII.2, emerged in the winter of 2016-2017. Here, we report the complete genome of this strain (Hu/GII/HK/2016/GII.P16-GII.2/CUHK-NS-1082), which was collected from a patient hospitalized with gastroenteritis in September 2016 in Hong Kong, China, and sequenced using next-generation sequencing. This genome had a 95.2% nucleotide identity to the closest sequence in GenBank., (Copyright © 2017 Chan et al.)
- Published
- 2017
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11. Molecular Epidemiology and Strain Comparison between Hepatitis E Viruses in Human Sera and Pig Livers during 2014 to 2016 in Hong Kong.
- Author
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Chan MCW, Kwok K, Hung TN, and Chan PKS
- Subjects
- Animals, Female, Genotype, Hepatitis E transmission, Hepatitis E virology, Hepatitis E virus classification, Hepatitis E virus isolation & purification, Hong Kong, Humans, Intestines virology, Male, Meat virology, Middle Aged, Molecular Epidemiology, Ostreidae virology, RNA, Viral genetics, Real-Time Polymerase Chain Reaction, Sheep virology, Swine Diseases virology, Foodborne Diseases virology, Hepatitis E epidemiology, Hepatitis E veterinary, Hepatitis E virus genetics, Liver virology, Swine virology
- Abstract
Hepatitis E virus (HEV) causes substantial morbidity and mortality in developing countries and is considered an emerging foodborne pathogen in developed countries in which it was previously not endemic. To investigate genetic association between human HEV infection and HEV-contaminated high-risk food in Hong Kong, we compared local virus strains obtained from hepatitis E patient sera with those surveyed from high-risk food items during 2014 to 2016. Twenty-four cases of laboratory-confirmed human HEV infections were identified from January 2014 to March 2016 in our hospitals. Five types of food items at risk of HEV contamination were purchased on a biweekly basis from April 2014 to March 2016 in two local market settings: supermarkets (lamb, oyster, and pig liver) and wet markets (oyster, pig blood curd, pig large intestine, and pig liver). HEV RNA detection was performed by a real-time reverse transcription-PCR assay. HEV RNA was detected in pig liver, pig intestine, and oyster samples with prevalences of 1.5%, 0.4%, and 0.2%, respectively. Neighbor-joining phylogenetic inference showed that all human and swine HEV strains belonged to genotype 4. HEV subtype distributions in humans and swine were highly comparable: subtype 4b predominated, while subtype 4d was the minority. Local human and swine HEV genotype 4 strains shared over 95% nucleotide identity and were genetically very similar, implicating swine as an important foodborne source of autochthonous human HEV infections in Hong Kong. Action should be taken to raise the awareness among public and health care professionals of hepatitis E as an emerging foodborne disease., (Copyright © 2017 American Society for Microbiology.)
- Published
- 2017
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12. Recurrent Infections of Emergent Norovirus GII.17 in an Elderly.
- Author
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Chan MC, Lee N, Hung TN, Chan LY, Kwok K, Wong RY, and Chan PK
- Published
- 2017
- Full Text
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13. Reduced Diagnostic Performance of Two Norovirus Antigen Enzyme Immunoassays for the Emergent Genogroup II Genotype 17 Kawasaki 2014 Variant.
- Author
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Chan MCW, Kwok K, Hung TN, and Chan PKS
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- Adolescent, Adult, Aged, Asia, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Norovirus classification, Norovirus genetics, Sensitivity and Specificity, Young Adult, Antigens, Viral analysis, Caliciviridae Infections diagnosis, Clinical Laboratory Techniques methods, False Negative Reactions, Genotype, Immunoenzyme Techniques methods, Norovirus isolation & purification
- Abstract
Two commonly used norovirus enzyme immunoassays have reduced diagnostic performance, with clinical sensitivities ranging from 11% to 35% for the detection of the recently emerging genogroup II genotype 17 (GII.17) Kawasaki 2014 variant that caused the majority of infections in Asia during the winter of 2014 to 2015. False-negative results can compromise infection control and patient management., (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)
- Published
- 2016
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14. Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014.
- Author
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Chan MC, Lee N, Hung TN, Kwok K, Cheung K, Tin EK, Lai RW, Nelson EA, Leung TF, and Chan PK
- Subjects
- Adolescent, Adult, Aged, Australia epidemiology, Caliciviridae Infections epidemiology, Child, Child, Preschool, Disease Outbreaks, Female, Gastroenteritis epidemiology, Genotype, Hong Kong epidemiology, Humans, Male, Middle Aged, Molecular Sequence Data, Norovirus classification, Phylogeny, Seasons, Viral Proteins genetics, Young Adult, Caliciviridae Infections virology, Evolution, Molecular, Gastroenteritis virology, Norovirus genetics, Norovirus isolation & purification
- Abstract
Norovirus genogroup II genotype 4 (GII.4) has been the predominant cause of viral gastroenteritis since 1996. Here we show that during the winter of 2014-2015, an emergent variant of a previously rare norovirus GII.17 genotype, Kawasaki 2014, predominated in Hong Kong and outcompeted contemporary GII.4 Sydney 2012 in hospitalized cases. GII.17 cases were significantly older than GII.4 cases. Root-to-tip and Bayesian BEAST analyses estimate GII.17 viral protein 1 (VP1) evolves one order of magnitude faster than GII.4 VP1. Residue substitutions and insertion occur in four of five inferred antigenic epitopes, suggesting immune evasion. Sequential GII.4-GII.17 infections are noted, implicating a lack of cross-protection. Virus bound to saliva of secretor histo-blood groups A, B and O, indicating broad susceptibility. This fast-evolving, broadly recognizing and probably immune-escaped emergent GII.17 variant causes severe gastroenteritis and hospitalization across all age groups, including populations who were previously less vulnerable to GII.4 variants; therefore, the global spread of GII.17 Kawasaki 2014 needs to be monitored.
- Published
- 2015
- Full Text
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15. Synthesis and anti-proliferative activity of novel azazerumbone conjugates with chalcones.
- Author
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Truong VV, Nam TD, Hung TN, Nga NT, Quan PM, Chinh LV, and Jung SH
- Subjects
- Antineoplastic Agents pharmacology, Cell Line, Tumor, Chalcones pharmacology, Drug Screening Assays, Antitumor, Ellipticines pharmacology, Humans, Lactams chemical synthesis, Sesquiterpenes pharmacology, Stereoisomerism, Structure-Activity Relationship, Antineoplastic Agents chemical synthesis, Chalcones chemical synthesis, Lactams pharmacology
- Abstract
The conjugation of azazerumbone ((3E,7E,11E)-5,5,8,12-tetramethylazacyclododeca-3,7,11-trien-2-one (7)) and 2,4-dihydroxychalcones was carried out for the preparation of novel target compounds 9a-g with 1-ethylene-4-methylene-1,2,3-triazole linker and 10a-f with propylene linker between amide nitrogen of azazerumbone and 4-hydroxy group of chalcone. The anti-proliferative activity of these compounds against the LU-1, Hep-G2, MCF-7 and SW480 human cancer cell lines were significantly improved compared to those of azazerumbone or zerumbone. The anti-proliferative activities of (3E,7E,11E)-1-((1-(2-(3-hydroxy-4-((E)-3-(3-methoxyphenyl)acryloyl)phenoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-5,5,8,12-tetramethyl azacyclododeca-3,7,11-trien-2-one (9b) and (3E,7E,11E)-1-(3-(4-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)phenoxy)propyl)-5,5,8,12-tetramethylazacyclododeca-3,7,11-trien-2-one (10d) are nearly comparable to those of ellipticine., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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16. Complete Genome Sequence of a Novel Recombinant GII.Pe_GII.17 Norovirus Strain from Hong Kong in 2015.
- Author
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Chan MC, Hung TN, Kwok K, and Chan PK
- Abstract
The complete genome sequence of a novel recombinant GII.Pe_GII.17 norovirus strain, tentatively named GII.17 Hong Kong 2015, was determined. RNA-dependent RNA polymerase has 95.6% and 98.4% and viral protein 1 has 90.6% and 95.9% identity at the nucleotide and amino acid levels, respectively, to the closest sequences in GenBank., (Copyright © 2015 Chan et al.)
- Published
- 2015
- Full Text
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17. Inertial sensor-based two feet motion tracking for gait analysis.
- Author
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Hung TN and Suh YS
- Subjects
- Algorithms, Humans, Walking physiology, Foot physiology, Gait physiology, Monitoring, Ambulatory instrumentation, Motion
- Abstract
Two feet motion is estimated for gait analysis. An inertial sensor is attached on each shoe and an inertial navigation algorithm is used to estimate the movement of both feet. To correct inter-shoe position error, a camera is installed on the right shoe and infrared LEDs are installed on the left shoe. The proposed system gives key gait analysis parameters such as step length, stride length, foot angle and walking speed. Also it gives three dimensional trajectories of two feet for gait analysis.
- Published
- 2013
- Full Text
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