Search

Your search keyword '"Humphries H"' showing total 147 results
Start Over Author "Humphries H"
147 results on '"Humphries H"'

4. SIgA, TGF-beta 1, IL-10, and TNF alpha in Colostrum Are Associated with Infant Group B Streptococcus Colonization

Author

Le Doare, K, Bellis, K, Faal, A, Birt, J, Munblit, D, Humphries, H, Taylor, S, Warburton, F, Heath, PT, Kampmann, B, and Gorringe, A

Subjects
bacteria, bacterial infections and mycoses, reproductive and urinary physiology
Abstract

Background: Group B Streptococcus (GBS) is a major cause of mortality and morbidity in infants and is associated with transmission from a colonized mother at birth and via infected breastmilk. Although maternal/infant colonization with GBS is common, the majority of infants exposed to GBS remain unaffected. The association between breastmilk immune factors and infant colonization and disease prevention has not been elucidated.\ud \ud Objectives: We have investigated the association between SIgA and cytokines in breastmilk and infant GBS colonization and clearance.\ud \ud Methods: Mother/infant GBS colonization was determined in a prospective cohort of 750 Gambian mother/infant pairs followed to day 89 of life. Anti-GBS secretory IgA bound to the surface of whole bacteria was assessed by flow cytometry and a panel of 12 cytokines quantified by mesoscale discovery in colostrum, breastmilk and serum.\ud \ud Results: Compared with infants receiving low anti-GBS SIgA in colostrum, infants receiving high anti-GBS SIgA were at decreased risk of GBS colonization for serotypes III and V. Infants colonized at day 6 were twice as likely to receive colostrum with high TGF-β1, TNFα, IL10, and IL-6 compared to uncolonized infants. Infants receiving high colostral TGF-β1, TNFα, and IL-6 had two-fold enhanced GBS clearance between birth and day 89.\ud \ud Conclusion: Our results suggest that the infant GBS colonization risk diminishes with increasing anti-GBS SIgA antibody in breastmilk and that key maternally derived cytokines might contribute to protection against infant colonization. These findings might be leveraged to develop interventions including maternal vaccination that may reduce infant GBS colonization.

Published
2017

5. SIgA, TGF-ß1, IL-10 and TNFa in colostrum are associated with infant Group B Streptococcus colonisation

Author

Mehring-Le Doare, KEK, Bellis, K, Faal, A, Birt, J, Munblit, D, Humphries, H, Taylor, S, Warburton, F, Heath, PT, Gorringe, A, Kampmann, B, and Thrasher Research Fund

Subjects
bacteria, bacterial infections and mycoses, reproductive and urinary physiology
Abstract

Background: Group B Streptococcus is a major cause of mortality and morbidity in infants and is associated with transmission from a colonised mother at birth and via infected breastmilk. Although maternal/infant colonisation with Group B Streptococcus (GBS) is common, the majority of infants exposed to GBS remain unaffected. The association between breastmilk immune factors and infant colonisation and disease prevention has not been elucidated. Objectives: We have investigated the association between SIgA and cytokines in breastmilk and infant GBS colonisation and clearance. Methods: Mother/infant GBS colonisation was determined in a prospective cohort of 750 Gambian mother/infant pairs followed to day 90 of life. Anti-GBS secretory IgA bound to the surface of whole bacteria was assessed by flow cytometry and a panel of 12 cytokines quantified by mesoscale discovery in colostrum, breastmilk and serum. Results: Compared with infants receiving low anti-GBS SIgA in colostrum, infants receiving high anti-GBS SIgA were at decreased risk of GBS colonisation for serotypes III and V. Infants colonised at day 6 were twice as likely to receive colostrum with high TGF- β1, TNFα, IL10 and IL-6 compared to uncolonised infants. Infants receiving high colostral TGF- β1, TNFα and IL-6 had two-fold enhanced GBS clearance between birth and day 90. Conclusion: Our results suggest that the infant GBS colonisation risk diminishes with increasing anti-GBS SIgA antibody in breastmilk and that key maternally-derived cytokines might contribute to protection against infant colonisation. These findings might be leveraged to develop interventions including maternal vaccination that may reduce infant GBS colonisation.

Published
2017

6. Association between functional antibody against Group B Streptococcus and maternal and infant colonization in a Gambian cohort

Author

Le Doare, K, Faal, A, Jaiteh, M, Sarfo, F, Taylor, S, Warburton, F, Humphries, H, Birt, J, Jarju, S, Darboe, S, Clarke, E, Antonio, M, Foster-Nyarko, E, Heath, PT, Gorringe, A, and Kampmann, B

Subjects
Group B Streptococcus, Adult, Mothers, Article, Cohort Studies, Young Adult, Pregnancy, Neonatal, Nasopharynx, Streptococcal Infections, Humans, Meningitis, Longitudinal Studies, Pregnancy Complications, Infectious, Child, reproductive and urinary physiology, Vaccines, Infant, Newborn, Infant, Streptococcus, Opsonin Proteins, bacterial infections and mycoses, Fetal Blood, Flow Cytometry, Antibodies, Bacterial, Infectious Disease Transmission, Vertical, Child, Preschool, Carrier State, Complement C3b, Immunologic Techniques, bacteria, Female, Gambia, Immunity, Maternally-Acquired
Abstract

Highlights • As maternally-derived anti-GBS antibody increases infant colonization risk decreases. • There is a serotype-specific threshold above which an infant is uncolonised with GBS. • Higher anti-GBS antibody is associated with infant clearance of GBS between birth and 3 months., Background Vertical transmission of Group B Streptococcus (GBS) is a prerequisite for early-onset disease and a consequence of maternal GBS colonization. Disease protection is associated with maternally-derived anti-GBS antibody. Using a novel antibody-mediated C3b/iC3b deposition flow cytometry assay which correlates with opsonic killing we developed a model to assess the impact of maternally-derived functional anti-GBS antibody on infant GBS colonization from birth to day 60–89 of life. Methods Rectovaginal swabs and cord blood (birth) and infant nasopharyngeal/rectal swabs (birth, day 6 and day 60–89) were obtained from 750 mother/infant pairs. Antibody-mediated C3b/iC3b deposition with cord and infant sera was measured by flow cytometry. Results We established that as maternally-derived anti-GBS functional antibody increases, infant colonization decreases at birth and up to three months of life, the critical time window for the development of GBS disease. Further, we observed a serotype (ST)-dependent threshold above which no infant was colonized at birth. Functional antibody above the upper 95th confidence interval for the geometric mean concentration was associated with absence of infant GBS colonization at birth for STII (p

Published
2017

7. Irish Society of Gastroenterology — Summer Meeting Held at Educational Centre, Althnagelvin Area Hospital, Londonderry on Friday 5th and Saturday 6th June, 1987

Author

Geraghty, J. G., Burke, P. E., McGovern, E., Shaw, K. M., Tobin, A., O’Leary, D., Dillon, M. E., O’Morain, C., Doyle, C. T., Brady, Caitriona, Gibney, M. J., Kelly, S. B., Wall, J., Panesar, K. J. S., O’Donohoe, M. K., Blake, A., Waldron, R. P., Dervan, P., Fitzpatrick, J. M., Cotter, P., Burke, G. J., Moran, K., McEntee, G., Jones, B., Duignan, J. P., Hone, R., O’Malley, E., Brennan, F., Whitehead, H., O’Connor, F. A., O’Dwyer, P. J., Martin, E. W., Kelly, S. B., Hershman, M. J., Habib, N. A., Williamson, R. C. N., Spencer, J., Wood, C. B., Kelly, Jacinta, Weir, D. G., Feighery, C., Doyle, C. T., Hanjavanit, C., Mulcahy, M. F., Courtney, M. G., Daly, P. A., Temperley, I. J., Keeling, P. W. N., Weir, D. G., Keating, J. J., Maxwell, W. J., Hogan, F. P., Keeling, P. W. N., McColl, Teresa, O’Leary, D., O’Morain, C. A., O’Connell, P. R., Horgan, P. G., Kirwan, W. O., O’Reilly, T., MacMathuna, P., Keeling, P. W. N., Feely, J., MacGowan, S. W., Bouchier-Hayes, D. J., Broe, P. J., Kennedy, N. P., Walsh, J. P., Maxwell, W. P., Hogan, F. P., Keeling, P. W. N., Coghlan, G., Gilligan, D., Humphries, H., McKenna, D., Dooley, C., Sweeney, E., Keane, C., O’Morain, C., O’Mahony, S., Whelton, M. J., Kearney, J., Keating, J., Kennedy, N., Keeling, P. W. N., Gibney, M. J., Deasy, J., Primrose, J., Holdsworth, P., Quirk, P., Dixon, M., Johnston, D., Healy, M., O’Connor, M. P., Weir, D. G., Keane, C. T., O’Moore, R. R., Nally, C. V., McMullin, L. J., Cianachan, A. S., Scott, G. W., O’Connor, M. P., Healy, M., Keane, C. T., O’Moore, R. R., Weir, D. G., Walsh, T. N., O’Malley, V. P., Given, H. F., O’Connor, H. J., Burrows, F. G., Neuberger, J., Elias, E., Kennedy, M. M., Hayes, M., Gibney, M. J., Keeling, P. W. N., Collins, A. -M., O’Connor, M. P., Weir, D. G., Gibney, M., Keeling, P., O’Sullivan, G., Kent, P., Gillen, P., Hennessy, T. P. J., Maxwell, W. J., Hogan, F. P., Keating, J. J., Keeling, P. W. N., Deasy, J. M., Lavelle, J. P., Clery, A. P., Coghlan, G., Gilligan, D., Humphries, H., McKenna, D., Sweeney, E., Keane, C., and O’Morain, C.

Published
1988
Full Text
View/download PDF

8. Irish Society of Gastroenterology — Winter Meeting Held at Freeman Auditorium, Mater Misericordiae Hospital, Dublin on Friday, 20th and Saturday, 21st November, 1987

Author

Brown, J. S., Humphreys, W. W., Parks, T. G., Dolan, C., O’Farrelly, C., Weiser, H., Whelan, A., Weir, D. G., Feighery, C., Mackle, E. J., Parks, T. G., Pender, D., Moghissi, K., Geraghty, J. G., Anderson, W. J., Carter, D. C., Cuddihy, A., Jenkins, D., Whelton, M. J., Gilligan, D., Cafferkey, M., Keane, C., O’Morain, C., MacMathuna, P., O’Connor, M. K., O’Connor, M. P., Freyne, P., Keeling, P. W. N., Deasy, J. M., Lavelle, J. P., Clery, A. P., Mackle, E. J., Sawhney, B. B., Mills, J. O. M., Parks, T. G., O’Connor, H. J., Ellis, W. R., Manning, A. P., Lintott, D. L., McMahon, M. J., Axon, A. T. B., Stuart, R., Byrne, P., Keeling, P., Connolly, J., Keane, R. M., Hennessy, T. P. J., Courtney, M. G., McDonald, G. S. A., Hourihane, D. O’B., Weir, D. G., McGibney, Carol, Darzi, A., Monson, J. R. T., Morrison, P., Tanner, W. A., Keane, F. B., Tobin, A., Gilligan, D., Hutchinson, L., Casey, E., McKenna, D., Keane, C. T., Sweeney, E. A., O’Morain, C. A., MacMathuna, P., Foley, B., O’Reilly, T., Chua, A., Feely, J., Keeling, P. W. N., Kelly, C. P., Dolan, C., Feighery, C., Weir, D. G., Darzi, A., Monson, J. R. T., Kay, E., Hurley, C. D., Tanner, W. A., Keane, F. B. V., Deasy, J. M., Carr, J., Clery, A. P., O’Donoghue, D. P., Duffy, M. J., Afdhal, N. H., Creagh, T., Broe, P., Bouchier-Hayes, D., Moran, B. J., Busch, I., Singleton, J. McL, Johnston, P., O’Brien, M., Dervan, P., Crowe, J., Lennon, J., Carney, D. N., Bourke, S., Murphy, B., Maher, K., Stafford, F., O’Morain, C., Daly, C. A., Gorey, T. F., Lavelle, J., Coakley, J. B., Bouchier-Hayes, D., Peng, S. Y., Parks, T. G., Maxwell, W. J., Keating, J., Hogan, F. P., McDonald, G. S. A., Keeling, P. W. N., Coyle, D., Gorey, T. F., Leahy, A. L., Fitzpatrick, P., Bouchier-Hayes, D., O’Donoghue, D. P., Duffy, M. J., Afdhal, N. H., Waldron, D. J., Gill, R. C., Bowes, K. L., Gallagher, R. B., Cervi, P., Dolan, C., Kelly, J., Weir, D. G., Feighery, C., Lavelle, E. M., Stevens, F. M., Duffy, B. S., Coghlan, J. G., Gilligan, D., Humphries, H., McKenna, D., Sweeney, E., Keane, C., O’Morain, C., Murray, D., O’Mahony, S., Buchanan, K., and Whelton, M.

Published
1988
Full Text
View/download PDF

9. Screening for 'window-period' acute HIV infection among pregnant women in rural South Africa

Author

Kharsany, Ayesha B. M., Hancock, N., Frohlich, Janet A., Humphries, H. R., Abdool Karim, Salim, and Abdool Karim, Quarraisha

Subjects
Adult, Male, Rural Population, Adolescent, Epidemiology, Enzyme-Linked Immunosorbent Assay, HIV Infections, HIV Antibodies, Article, South Africa, Young Adult, Pregnancy, Virology, Ambulatory Care, Humans, Mass Screening, Pregnancy Complications, Infectious, Incidence, virus diseases, Middle Aged, Viral Load, Infectious Disease Transmission, Vertical, Acute Disease, RNA, Viral, Female, Nucleic Acid Amplification Techniques
Abstract

OBJECTIVES: The aim of this study was to evaluate the HIV-1 RNA pooled nucleic acid amplification testing (NAAT) strategy to screen pregnant women in the 'window period' of acute HIV infection (AHI) in rural South Africa. METHODS: In 2007 and 2008, 750 consecutive pregnant women on their first antenatal care visit to a primary health care clinic were tested anonymously for HIV infection. HIV-1 RNA pooled NAAT was performed on HIV antibody-negative samples. All positive pools were tested individually and positive samples were classified as incident cases to calculate HIV incidence. RESULTS: The overall HIV prevalence was 37.3% [95% confidence interval (CI) 34.3-41.3]. Of the 467 HIV antibody-negative samples, four (0.9%) were HIV-1 RNA-positive. The mean viral load in the four samples was 386 260 HIV-1 RNA copies/mL (range 64 200-1 228130). The HIV incidence was 11.2%per year (95% CI 0.3-22.1) and all women with AHI were 21 years of age. CONCLUSIONS: Identifying AHI in pregnancy is important for health interventions to reduce perinatal and heterosexual transmission of HIV, and to estimate HIV incidence for epidemiological surveillance.

Published
2010

11. Productivity is a poor predictor of plant species richness

Author

Adler, P B, Seabloom, E W, Borer, E T, Hillebrand, H, Hautier, Y, Hector, A, Harpole, W Stanley; https://orcid.org/0000-0002-3404-9174, O'Halloran, L R, Grace, J B, Anderson, T Michael, Bakker, J D, Biederman, L A, Brown, C S, Buckley, Y M, Calabrese, L B, Chu, C J, Cleland, E E, Collins, S L, Cottingham, K L, Crawley, M J, Damschen, E I, Davies, K F, DeCrappeo, N M, Fay, P A, Firn, J, Frater, P, Gasarch, E I, Gruner, D S, Hagenah, N, Hille Ris Lambers, J, Humphries, H, Jin, V L, Kay, A D, Kirkman, K P, Klein, J A, Knops, J M H, La Pierre, K J, Lambrinos, J G, Li, W, MacDougall, A S, McCulley, R L, Melbourne, B A, Mitchell, C E, Moore, J L, Morgan, J W, Mortensen, B, Orrock, J L, Prober, S M, Pyke, D A, Risch, A C, Schuetz, M, Smith, M D, Stevens, C J, Sullivan, L L, Wang, G, Wragg, P D, Wright, J P, Yang, L H, Adler, P B, Seabloom, E W, Borer, E T, Hillebrand, H, Hautier, Y, Hector, A, Harpole, W Stanley; https://orcid.org/0000-0002-3404-9174, O'Halloran, L R, Grace, J B, Anderson, T Michael, Bakker, J D, Biederman, L A, Brown, C S, Buckley, Y M, Calabrese, L B, Chu, C J, Cleland, E E, Collins, S L, Cottingham, K L, Crawley, M J, Damschen, E I, Davies, K F, DeCrappeo, N M, Fay, P A, Firn, J, Frater, P, Gasarch, E I, Gruner, D S, Hagenah, N, Hille Ris Lambers, J, Humphries, H, Jin, V L, Kay, A D, Kirkman, K P, Klein, J A, Knops, J M H, La Pierre, K J, Lambrinos, J G, Li, W, MacDougall, A S, McCulley, R L, Melbourne, B A, Mitchell, C E, Moore, J L, Morgan, J W, Mortensen, B, Orrock, J L, Prober, S M, Pyke, D A, Risch, A C, Schuetz, M, Smith, M D, Stevens, C J, Sullivan, L L, Wang, G, Wragg, P D, Wright, J P, and Yang, L H

Abstract

For more than 30 years, the relationship between net primary productivity and species richness has generated intense debate in ecology about the processes regulating local diversity. The original view, which is still widely accepted, holds that the relationship is hump-shaped, with richness first rising and then declining with increasing productivity. Although recent meta-analyses questioned the generality of hump-shaped patterns, these syntheses have been criticized for failing to account for methodological differences among studies. We addressed such concerns by conducting standardized sampling in 48 herbaceous-dominated plant communities on five continents. We found no clear relationship between productivity and fine-scale (meters−2) richness within sites, within regions, or across the globe. Ecologists should focus on fresh, mechanistic approaches to understanding the multivariate links between productivity and richness.

Published
2011

19. Calcium and calmodulin in the regulation of human thyroid adenylate cyclase activity

Author

Lakey, T, Mac Neil, S, Humphries, H, Walker, S W, Munro, D S, and Tomlinson, S

Abstract

TSH (thyrotropin)-stimulated human thyroid adenylate cyclase has a biphasic response to Ca2+, being activated by submicromolar Ca2+ (optimum 22nM), with inhibition at higher concentrations. Calmodulin antagonists caused an inhibition of TSH-stimulated adenylate cyclase in a dose-dependent manner. Inhibition of TSH-and TSIg-(thyroid-stimulating immunoglobulins)-stimulated activity was more marked than that of basal, NaF- or forskolin-stimulated activity. This inhibition was not due to a decreased binding of TSH to its receptor. Addition of pure calmodulin to particulate preparations of human non-toxic goitre which had not been calmodulin-depleted had no effect on adenylate cyclase activity. EGTA was ineffective in removing calmodulin from particulate preparations, but treatment with the tervalent metal ion La3+ resulted in a loss of up to 98% of calmodulin activity from these preparations. Addition of La3+ directly to the adenylate cyclase assay resulted in a partial inhibition of TSH- and NaF-stimulated activity, with 50% inhibition produced by 5.1 microM and 4.0 microM-La3+ respectively. Particulate preparations with La3+ showed a decrease of TSH- and NaF-stimulated adenylate cyclase activity (approx. 40-60%). In La3+-treated preparations there was a decrease in sensitivity of TSH-stimulated adenylate cyclase to Ca2+ over a wide range of Ca2+ concentrations, but most markedly in the region of the optimal stimulatory Ca2+ concentration. In particulate preparations from which endogenous calmodulin had been removed by La3+ treatment, the addition of pure calmodulin caused an increase (73 +/- 22%; mean +/- S.E.M., n = 8) in TSH-stimulated thyroid adenylate cyclase activity. This was seen in 8 out of 13 experiments.

Published
1985
Full Text
View/download PDF

20. Interaction of epidermal growth factor with receptors on human and porcine thyroid membranes

Author

Humphries, H., MacNeil, S., Munro, D. S., and Tomlinson, S.

Abstract

Recent evidence suggests that epidermal growth factor (EGF) may play an important role in the regulation of thyroid growth and function. We have examined the interaction of murine EGF (mEGF) with human and porcine thyroid membranes and compared this with the binding of bovine TSH (bTSH) using 125I-labelled hormones as tracers. The characteristics of the binding of mEGF were found to be similar for human and porcine thyroid membranes. Epidermal growth factor bound with high affinity (affinity constant = 1·4 × 109l/mol); the density of binding sites was low compared with the TSH receptor. At 37 °C, the binding of 125I-labelled EGF was maximal at 1 h and was saturable in the presence of unlabelled EGF; half-maximal inhibition was at 1 ng EGF/tube (0·5 nmol/l) using 0·5 mg membrane protein/tube. Unlabelled bTSH had no effect on the binding of labelled EGF. Similarly, unlabelled EGF did not affect the binding of labelled TSH; hence it was concluded that mEGF and bTSH bound to independent sites. Epidermal growth factor had no effect on adenylate cyclase activity in membranes prepared from human non-toxic goitre; increasing concentrations of EGF did not affect basal, TSH-stimulated or fluoride-stimulated enzyme activity.J. Endocr.(1984) 102, 57–61

Published
1984
Full Text
View/download PDF

23. (View) Plate II (in Volume III). Port Dick, near Cook's Inlet.

Author

Vancouver, George, 1757-1798, Humphries, H., B.T. Pouncy, and W. Alexander

Subjects
London
Abstract

Atlas, without title, as issued. Contains ten charts and six sheets of views (profiles of parts of the coastlines). Compare the English charts to the French issues in the French Neptune of 1820. Vancouver's charts were the most accurate of the area for many years into the 19th century. In addition to the eight Northwest Coast charts, there is a "Chart shewing part of the S.W. Coast of New Holland" (with inset charts of New Zealand) and "A Chart of the Sandwich Islands." Maps are without color and bound into half leather burgundy cloth covered boards with "Atlas To Vancouvers Voyage" stamped in gilt on a red leather label on the spine. Streeter calls the accounts of the voyage, "One of the most important accounts of the exploration of the Pacific Northwest and New Zealand, and valuable source of information about Tahiti and the Hawaiian Islands in the last decade of the eighteenth century." Voyage accounts are bound in three volumes, all in half leather with green cloth boards. "Vancouver's Voyage" and the volume number embossed in gold on spine., P197; Streeter 3497; Sabin 98443; Cowan 1933; Wagner 853-860.

Published
1798

24. (View) Plate VII (in Volume I). Friendly Cove, Nootka Sound.

Author

Vancouver, George, 1757-1798, Humphries, H., Heath, and W. Alexander

Subjects
London
Abstract

Atlas, without title, as issued. Contains ten charts and six sheets of views (profiles of parts of the coastlines). Compare the English charts to the French issues in the French Neptune of 1820. Vancouver's charts were the most accurate of the area for many years into the 19th century. In addition to the eight Northwest Coast charts, there is a "Chart shewing part of the S.W. Coast of New Holland" (with inset charts of New Zealand) and "A Chart of the Sandwich Islands." Maps are without color and bound into half leather burgundy cloth covered boards with "Atlas To Vancouvers Voyage" stamped in gilt on a red leather label on the spine. Streeter calls the accounts of the voyage, "One of the most important accounts of the exploration of the Pacific Northwest and New Zealand, and valuable source of information about Tahiti and the Hawaiian Islands in the last decade of the eighteenth century." Voyage accounts are bound in three volumes, all in half leather with green cloth boards. "Vancouver's Voyage" and the volume number embossed in gold on spine., P197; Streeter 3497; Sabin 98443; Cowan 1933; Wagner 853-860.

Published
1798

26. Reaction of D-ribo-Hexos-3-ulose and of 1,2:5,6-Di-O-Isopropylidene-alpha-D-ribo-hexo-1,4-furanos-3-ulose 3-hydrate with Methanol-Hydrogen Chloride. A preparation of D-ribo-3-Hexulose

Author

SVENSKA TRAFORSKNINGSINSTITUTET STOCKHOLM, Humphries,H. Peter, Theander,Olof, SVENSKA TRAFORSKNINGSINSTITUTET STOCKHOLM, Humphries,H. Peter, and Theander,Olof

Abstract

The reaction of D-ribo-hexos-3-ulose with methanol-hydrogen chloride yielded as major products methyl (methyl beta-D-ribo-hexo-1,4-furanosid)-beta-D-3-ulo-3,6-furanoside, and methyl (methyl alpha-D-ribo-hexo-1,4-furanosid)-beta-D-3-ulo-3,6-furanoside. Similar treatment of 1,2:5,6-di-O-isopropylidene-alpha-D-ribo-hexo-1,4-furanos-3-ulose 3-hydrate afforded the same products together with methyl (1,2-O-isopropylidene-alpha-D-ribo-hexo-1,4-furanos)-beta-D-3-ulo-3,6-furanoside. (Author), Prepared in cooperation with Swedish Forest Products Research Lab., Stockholm.

Published
1970

Catalog

Books, media, physical & digital resources
See catalog results