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3. Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis: Multidisciplinary Consensus Statement and Evidence‐Based Review with Recommendations

Author

Roland, Lauren T, Humphreys, Ian M, Le, Christopher H, Babik, Jennifer M, Bailey, Christopher E, Ediriwickrema, Lilangi S, Fung, Monica, Lieberman, Joshua A, Magliocca, Kelly R, Nam, Hannah H, Teo, Neville W, Thomas, Penelope C, Winegar, Blair A, Birkenbeuel, Jack L, David, Abel P, Goshtasbi, Khodayar, Johnson, Patricia G, Martin, Elaine C, Nguyen, Theodore V, Patel, Neil N, Qureshi, Hannan A, Tay, Kaijun, Vasudev, Milind, Abuzeid, Waleed M, Hwang, Peter H, Jafari, Aria, Russell, Matthew S, Turner, Justin H, Wise, Sarah K, and Kuan, Edward C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Humans, Prospective Studies, Invasive Fungal Infections, Acute Disease, Prognosis, Sinusitis, antifungals, aspergillosis, fungus, immunosuppression, intracranial, invasive fungal sinusitis, management, mucormycosis, orbit, outcomes, surgery, survival, Immunology, Clinical sciences
Abstract

BackgroundAcute invasive fungal sinusitis (AIFS) is an aggressive disease that requires prompt diagnosis and multidisciplinary treatment given its rapid progression. However, there is currently no consensus on diagnosis, prognosis, and management strategies for AIFS, with multiple modalities routinely employed. The purpose of this multi-institutional and multidisciplinary evidence-based review with recommendations (EBRR) is to thoroughly review the literature on AIFS, summarize the existing evidence, and provide recommendations on the management of AIFS.MethodsThe PubMed, EMBASE, and Cochrane databases were systematically reviewed from inception through January 2022. Studies evaluating management for orbital, non-sinonasal head and neck, and intracranial manifestations of AIFS were included. An iterative review process was utilized in accordance with EBRR guidelines. Levels of evidence and recommendations on management principles for AIFS were generated.ResultsA review and evaluation of published literature was performed on 12 topics surrounding AIFS (signs and symptoms, laboratory and microbiology diagnostics, endoscopy, imaging, pathology, surgery, medical therapy, management of extrasinus extension, reversing immunosuppression, and outcomes and survival). The aggregate quality of evidence was varied across reviewed domains.ConclusionBased on the currently available evidence, judicious utilization of a combination of history and physical examination, laboratory and histopathologic techniques, and endoscopy provide the cornerstone for accurate diagnosis of AIFS. In addition, AIFS is optimally managed by a multidisciplinary team via a combination of surgery (including resection whenever possible), antifungal therapy, and correcting sources of immunosuppression. Higher quality (i.e., prospective) studies are needed to better define the roles of each modality and determine diagnosis and treatment algorithms.

Published
2023

4. Sinonasal Tumors

Author

Johnson, Patricia G., Humphreys, Ian M., Schwartz, Theodore H., editor, Kong, Doo-Sik, editor, and Moe, Kris S., editor

Published
2024
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5. A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications

Author

Bliss, Carly M., Hulin-Curtis, Sarah L., Williams, Marta, Marušková, Mahulena, Davies, James A., Statkute, Evelina, Baker, Alexander T., Stack, Louise, Kerstetter, Lucas, Kerr-Jones, Lauren E., Milward, Kate F., Russell, Gabrielle, George, Sarah J., Badder, Luned M., Stanton, Richard J., Coughlan, Lynda, Humphreys, Ian R., and Parker, Alan L.

Published
2024
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6. Real-time Virtual Intraoperative CT for Image Guided Surgery

Author

Li, Yangming, Konuthula, Neeraja, Humphreys, Ian M., Moe, Kris, Hannaford, Blake, and Bly, Randall

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Computer Science - Robotics
Abstract

Abstract. Purpose: This paper presents a scheme for generating virtual intraoperative CT scans in order to improve surgical completeness in Endoscopic Sinus Surgeries (ESS). Approach: The work presents three methods, the tip motion-based, the tip trajectory-based, and the instrument based, along with non-parametric smoothing and Gaussian Process Regression, for virtual intraoperative CT generation. Results: The proposed methods studied and compared on ESS performed on cadavers. Surgical results show all three methods improve the Dice Similarity Coefficients > 86%, with F-score > 92% and precision > 89.91%. The tip trajectory-based method was found to have best performance and reached 96.87% precision in surgical completeness evaluation. Conclusions: This work demonstrated that virtual intraoperative CT scans improves the consistency between the actual surgical scene and the reference model, and improves surgical completeness in ESS. Comparing with actual intraoperative CT scans, the proposed scheme has no impact on existing surgical protocols, does not require extra hardware other than the one is already available in most ESS overcome the high costs, the repeated radiation, and the elongated anesthesia caused by actual intraoperative CTs, and is practical in ESS.

Published
2021

7. Real-time Informative Surgical Skill Assessment with Gaussian Process Learning

Author

Li, Yangming, Bly, Randall, Akkina, Sarah, Saxena, Rajeev C., Humphreys, Ian, Whipple, Mark, Moe, Kris, and Hannaford, Blake

Subjects
Computer Science - Machine Learning
Abstract

Endoscopic Sinus and Skull Base Surgeries (ESSBSs) is a challenging and potentially dangerous surgical procedure, and objective skill assessment is the key components to improve the effectiveness of surgical training, to re-validate surgeons' skills, and to decrease surgical trauma and the complication rate in operating rooms. Because of the complexity of surgical procedures, the variation of operation styles, and the fast development of new surgical skills, the surgical skill assessment remains a challenging problem. This work presents a novel Gaussian Process Learning-based heuristic automatic objective surgical skill assessment method for ESSBSs. Different with classical surgical skill assessment algorithms, the proposed method 1) utilizes the kinematic features in surgical instrument relative movements, instead of using specific surgical tasks or the statistics to assess skills in real-time; 2) provide informative feedback, instead of a summative scores; 3) has the ability to incrementally learn from new data, instead of depending on a fixed dataset. The proposed method projects the instrument movements into the endoscope coordinate to reduce the data dimensionality. It then extracts the kinematic features of the projected data and learns the relationship between surgical skill levels and the features with the Gaussian Process learning technique. The proposed method was verified in full endoscopic skull base and sinus surgeries on cadavers. These surgeries have different pathology, requires different treatment and has different complexities. The experimental results show that the proposed method reaches 100\% prediction precision for complete surgical procedures and 90\% precision for real-time prediction assessment.

Published
2021

8. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation

Author

Hulin-Curtis, Sarah, Geary, James K., MacLachlan, Bruce J., Altmann, Danny M., Baillon, Laury, Cole, David K., Greenshields-Watson, Alex, Hesketh, Sophie J., Humphreys, Ian R., Jones, Ian M., Lauder, Sarah N., Mason, Georgina H., Smart, Kathryn, Scourfield, D. Oliver, Scott, Jake, Sukhova, Ksenia, Stanton, Richard J., Wall, Aaron, Rizkallah, Pierre J., Barclay, Wendy S., Gallimore, Awen, and Godkin, Andrew

Published
2024
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11. Behavior Trees as a Representation for Medical Procedures

Author

Hannaford, Blake, Bly, Randall, Humphreys, Ian, and Whipple, Mark

Subjects
Computer Science - Human-Computer Interaction, Computer Science - Artificial Intelligence
Abstract

Objective: Effective collaboration between machines and clinicians requires flexible data structures to represent medical processes and clinical practice guidelines. Such a data structure could enable effective turn-taking between human and automated components of a complex treatment, accurate on-line monitoring of clinical treatments (for example to detect medical errors), or automated treatment systems (such as future medical robots) whose overall treatment plan is understandable and auditable by human experts. Materials and Methods: Behavior trees (BTs) emerged from video game development as a graphical language for modeling intelligent agent behavior. BTs have several properties which are attractive for modeling medical procedures including human-readability, authoring tools, and composability. Results: This paper will illustrate construction of BTs for exemplary medical procedures and clinical protocols. Discussion and Conclusion: Behavior Trees thus form a useful, and human authorable/readable bridge between clinical practice guidelines and AI systems., Comment: We are pleased to acknowledge support from National Science Foundation grant #IIS-1637444. arXiv admin note: text overlap with arXiv:1801.07864

Published
2018

12. University of Washington Quality of Life subdomain outcomes after treatment of sinonasal malignancy: A prospective, multicenter study.

Author

Maoz, Sabrina L., Golzar, Autreen, Choby, Garret, Hwang, Peter H., Wang, Eric W., Kuan, Edward C., Adappa, Nithin D., Geltzeiler, Mathew, Getz, Anne E., Humphreys, Ian M., Le, Christopher H., Pinheiro‐Neto, Carlos D., Fischer, Jakob L., Chan, Erik P., Abuzeid, Waleed M., Chang, Eugene H., Jafari, Aria, Kingdom, Todd T., Kohanski, Michael A., and Lee, Jivianne K.

Published
2024
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14. Generalized biomolecular modeling and design with RoseTTAFold All-Atom

Author

Krishna, Rohith, primary, Wang, Jue, additional, Ahern, Woody, additional, Sturmfels, Pascal, additional, Venkatesh, Preetham, additional, Kalvet, Indrek, additional, Lee, Gyu Rie, additional, Morey-Burrows, Felix S., additional, Anishchenko, Ivan, additional, Humphreys, Ian R., additional, McHugh, Ryan, additional, Vafeados, Dionne, additional, Li, Xinting, additional, Sutherland, George A., additional, Hitchcock, Andrew, additional, Hunter, C. Neil, additional, Kang, Alex, additional, Brackenbrough, Evans, additional, Bera, Asim K., additional, Baek, Minkyung, additional, DiMaio, Frank, additional, and Baker, David, additional

Published
2024
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15. Essential and virulence-related protein interactions of pathogens revealed through deep learning

Author

Humphreys, Ian R., primary, Zhang, Jing, additional, Baek, Minkyung, additional, Wang, Yaxi, additional, Krishnakumar, Aditya, additional, Pei, Jimin, additional, Anishchenko, Ivan, additional, Tower, Catherine A., additional, Jackson, Blake A., additional, Warrier, Thulasi, additional, Hung, Deborah T., additional, Peterson, S. Brook, additional, Mougous, Joseph D., additional, Cong, Qian, additional, and Baker, David, additional

Published
2024
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17. SNOT‐22 subdomain outcomes following treatment for sinonasal malignancy: A prospective, multicenter study.

Author

Grimm, David R., Beswick, Daniel M., Maoz, Sabrina L., Wang, Eric W., Choby, Garret W., Kuan, Edward C., Chan, Erik P., Adappa, Nithin D., Geltzeiler, Mathew, Getz, Anne E., Humphreys, Ian M., Le, Christopher H., Abuzeid, Waleed M., Chang, Eugene H., Jafari, Aria, Kingdom, Todd T., Kohanski, Michael A., Lee, Jivianne K., Nayak, Jayakar V., and Palmer, James N.

Published
2024
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18. Multiportal Retrograde Endoscopy to Enhance Surgical Target Visualization: A Pilot Study.

Author

Konuthula, Neeraja, Bly, Randall A., Abuzeid, Waleed M., Humphreys, Ian M., Masco, Vanessa V., Hannaford, Blake, and Moe, Kris S.

Subjects
ENDOSCOPIC surgery, SKULL base, SKULL surgery, DEPTH perception, PILOT projects, ENDOSCOPES
Abstract

Objective Current transnasal endoscopic techniques for sinus and skull base surgery use a single endoscope to provide visualization from one perspective curtailing depth perception and compromising visualization of the instrument–target interface. The view can be blocked by instruments, and collisions between instruments often occur. The objective of this study was to investigate the use of multiportal retrograde endoscopy to provide more accurate manipulation of the surgical target. Design Maxillary antrostomy and frontal sinusotomy were performed on three different cadavers by three different surgeons. A zero-degree rigid endoscope was introduced through the nose for the standard transnasal approach. A flexible endoscope was introduced transorally, directed past the palate superiorly, and then flexed 180 degrees for the retrograde view. Videos of the standard transnasal view from the rigid endoscope and retrograde view from the flexible endoscope were recorded simultaneously. Results All surgeries were able to be performed with dual-screen viewing of the standard and retrograde view. The surgeons noted that they utilized the retrograde view to adjust the location of ends/tips of their instruments. Four surgeons reviewed the videos and individually agreed that the visualization achieved provided a perspective otherwise not attainable with rigid transnasal endoscopy alone. Conclusion High-quality visualization of surgical targets such as the frontal or maxillary ostia can be challenging with rigid endoscopes alone. Multiportal retrograde endoscopy provides proof of concept that additional views of a surgical target can be achieved. Additional work is needed to further develop indications, techniques, and generalizability to targets beyond those investigated here. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

Author

Petersdorf, Effie W, Carrington, Mary, O'hUigin, Colm, Bengtsson, Mats, De Santis, Dianne, Dubois, Valerie, Gooley, Ted, Horowitz, Mary, Hsu, Katharine, Madrigal, J Alejandro, Maiers, Martin, Malkki, Mari, McKallor, Caroline, Morishima, Yasuo, Oudshoorn, Machteld, Spellman, Stephen, Villard, Jean, Stevenson, Phil, Apperley, Jane, Bardy, Peter, Bernard, Ghislaine, Bertrand, Yves, Bloor, Adrian, Bonini, Chiara, Buhler, Stephane, Bungener, Laura, Campbell, Helen, Carlson, Kristina, Carpenter, Ben, Cesbron, Anne, Chabannon, Christian, Chalandon, Yves, Chapman, Jeremy, Chebel, Réda, Chevallier, Patrice, Choi, Gerda, Collin, Matt, Cornelissen, Jan J, Crawley, Charles, D'Orsogna, Lloyd, Dalle, Jean-Hugues, Deconinck, Eric, DeMatteis, Muriel, Diviney, Mary, Dormoy, Anne, Gagne, Katia, Gibson, Brenda, Gilleece, Maria, Gottlieb, David, Gribben, John, Güngör, Tayfun, Haagenson, Mike, Hart, Cathie, Holdsworth, Rhonda, Humphreys, Ian, Kodera, Yoshihisa, Koh, Mickey, Labussière-Wallet, Hélène, Lankester, Arjan C, Lardy, Neubery, Lawson, Sarah, Leleu, Xavier, MacKinnon, Stephen, Malladi, Ram, Marsh, Steven GE, Martin, Murray, Mayor, Neema P, McQuaker, I Grant, Meijer, Ellen, Morishima, Satoko, Nikolousis, Emmanouil, Orchard, Kim, Passweg, Jacob, Patel, Amit, Patrick, Katherine, Pedron, Béatrice, Peniket, Andy, Perry, Julia, Petersen, Eefke, Potter, Victoria, Potter, Mike, Protheroe, Rachel, Raus, Nicole, Ruiz de Elvira, Carmen, Russell, Nigel, Schaap, Nicholaas PM, Schanz, Urs, Schouten, Harry, Skinner, Roderick, Snowden, John, Spierings, Eric, Steward, Colin, Tholouli, Eleni, Thornton, Alycia, Tilanus, Marcel, van de Meer, Arnold, Veelkens, Hendrik, Veys, Paul, Watson, Narelle, Weston, Lyanne, Wilson, Keith, Wilson, Marie, Wynn, Robert, Zsiros, József, Maiers, Martin J, and Spellman, Stephen R

Published
2020
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21. How Do Patients and Otolaryngologists Define Dizziness?

Author

Murphy, Brianna L., primary, Fischer, Jakob L., additional, Tolisano, Anthony M., additional, Navarro, Alvaro I., additional, Trinh, Lily, additional, Abuzeid, Waleed M., additional, Humphreys, Ian M., additional, Akbar, Nadeem A., additional, Shah, Sharan, additional, Schneider, John S., additional, Riley, Charles A., additional, and McCoul, Edward D., additional

Published
2024
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26. Generalized Biomolecular Modeling and Design with RoseTTAFold All-Atom

Author

Krishna, Rohith, primary, Wang, Jue, additional, Ahern, Woody, additional, Sturmfels, Pascal, additional, Venkatesh, Preetham, additional, Kalvet, Indrek, additional, Lee, Gyu Rie, additional, Morey-Burrows, Felix S, additional, Anishchenko, Ivan, additional, Humphreys, Ian R, additional, McHugh, Ryan, additional, Vafeados, Dionne, additional, Li, Xinting, additional, Sutherland, George A, additional, Hitchcock, Andrew, additional, Hunter, C Neil, additional, Baek, Minkyung, additional, DiMaio, Frank, additional, and Baker, David, additional

Published
2023
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27. International consensus statement on allergy and rhinology: Sinonasal tumors

Author

Kuan, Edward C., primary, Wang, Eric W., additional, Adappa, Nithin D., additional, Beswick, Daniel M., additional, London, Nyall R., additional, Su, Shirley Y., additional, Wang, Marilene B., additional, Abuzeid, Waleed M., additional, Alexiev, Borislav, additional, Alt, Jeremiah A., additional, Antognoni, Paolo, additional, Alonso‐Basanta, Michelle, additional, Batra, Pete S., additional, Bhayani, Mihir, additional, Bell, Diana, additional, Bernal‐Sprekelsen, Manuel, additional, Betz, Christian S., additional, Blay, Jean‐Yves, additional, Bleier, Benjamin S., additional, Bonilla‐Velez, Juliana, additional, Callejas, Claudio, additional, Carrau, Ricardo L., additional, Casiano, Roy R., additional, Castelnuovo, Paolo, additional, Chandra, Rakesh K., additional, Chatzinakis, Vasileios, additional, Chen, Simon B., additional, Chiu, Alexander G., additional, Choby, Garret, additional, Chowdhury, Naweed I., additional, Citardi, Martin J., additional, Cohen, Marc A., additional, Dagan, Roi, additional, Dalfino, Gianluca, additional, Dallan, Iacopo, additional, Dassi, Camila Soares, additional, de Almeida, John, additional, Tos, Angelo P. Dei, additional, DelGaudio, John M., additional, Ebert, Charles S., additional, El‐Sayed, Ivan H., additional, Eloy, Jean Anderson, additional, Evans, James J., additional, Fang, Christina H., additional, Farrell, Nyssa F., additional, Ferrari, Marco, additional, Fischbein, Nancy, additional, Folbe, Adam, additional, Fokkens, Wytske J., additional, Fox, Meha G., additional, Lund, Valerie J., additional, Gallia, Gary L., additional, Gardner, Paul A., additional, Geltzeiler, Mathew, additional, Georgalas, Christos, additional, Getz, Anne E., additional, Govindaraj, Satish, additional, Gray, Stacey T., additional, Grayson, Jessica W., additional, Gross, Bradley A., additional, Grube, Jordon G., additional, Guo, Ruifeng, additional, Ha, Patrick K., additional, Halderman, Ashleigh A., additional, Hanna, Ehab Y., additional, Harvey, Richard J., additional, Hernandez, Stephen C., additional, Holtzman, Adam L., additional, Hopkins, Claire, additional, Huang, Zhigang, additional, Huang, Zhenxiao, additional, Humphreys, Ian M., additional, Hwang, Peter H., additional, Iloreta, Alfred M., additional, Ishii, Masaru, additional, Ivan, Michael E., additional, Jafari, Aria, additional, Kennedy, David W., additional, Khan, Mohemmed, additional, Kimple, Adam J., additional, Kingdom, Todd T., additional, Knisely, Anna, additional, Kuo, Ying‐Ju, additional, Lal, Devyani, additional, Lamarre, Eric D., additional, Lan, Ming‐Ying, additional, Le, Hien, additional, Lechner, Matt, additional, Lee, Nancy Y., additional, Lee, Jivianne K., additional, Lee, Victor H., additional, Levine, Corinna G., additional, Lin, Jin‐Ching, additional, Lin, Derrick T., additional, Lobo, Brian C., additional, Locke, Tran, additional, Luong, Amber U., additional, Magliocca, Kelly R., additional, Markovic, Svetomir N., additional, Matnjani, Gesa, additional, McKean, Erin L., additional, Meço, Cem, additional, Mendenhall, William M., additional, Michel, Loren, additional, Na'ara, Shorook, additional, Nicolai, Piero, additional, Nuss, Daniel W., additional, Nyquist, Gurston G., additional, Oakley, Gretchen M., additional, Omura, Kazuhiro, additional, Orlandi, Richard R., additional, Otori, Nobuyoshi, additional, Papagiannopoulos, Peter, additional, Patel, Zara M., additional, Pfister, David G., additional, Phan, Jack, additional, Psaltis, Alkis J., additional, Rabinowitz, Mindy R., additional, Ramanathan, Murugappan, additional, Rimmer, Ryan, additional, Rosen, Marc R., additional, Sanusi, Olabisi, additional, Sargi, Zoukaa B., additional, Schafhausen, Philippe, additional, Schlosser, Rodney J., additional, Sedaghat, Ahmad R., additional, Senior, Brent A., additional, Shrivastava, Raj, additional, Sindwani, Raj, additional, Smith, Timothy L., additional, Smith, Kristine A., additional, Snyderman, Carl H., additional, Solares, C. Arturo, additional, Sreenath, Satyan B., additional, Stamm, Aldo, additional, Stölzel, Katharina, additional, Sumer, Baran, additional, Surda, Pavol, additional, Tajudeen, Bobby A., additional, Thompson, Lester D. R., additional, Thorp, Brian D., additional, Tong, Charles C. L., additional, Tsang, Raymond K., additional, Turner, Justin H., additional, Turri‐Zanoni, Mario, additional, Udager, Aaron M., additional, van Zele, Thibaut, additional, VanKoevering, Kyle, additional, Welch, Kevin C., additional, Wise, Sarah K., additional, Witterick, Ian J., additional, Won, Tae‐Bin, additional, Wong, Stephanie N., additional, Woodworth, Bradford A., additional, Wormald, Peter‐John, additional, Yao, William C., additional, Yeh, Chien‐Fu, additional, Zhou, Bing, additional, Palmer, James N., additional, Abiri, Arash, additional, Adams, Carrie D., additional, Ayoub, Noel F., additional, Bitner, Benjamin F., additional, Boyd, Jacob T., additional, Chang, Michael T., additional, Chapurin, Nikita, additional, Chaskes, Mark B., additional, Chua, Andy, additional, Chung, Sei Y., additional, Contrera, Kevin J., additional, Dilley, Katelyn K., additional, Dutra, André Zanette, additional, Eide, Jacob G., additional, Fenberg, Rachel, additional, Godse, Neal R., additional, Jawad, Basit, additional, Johnson, Jared, additional, Johnson, B. Jake, additional, Judd, Ryan, additional, Khalife, Sarah, additional, Khosravi, Pooya, additional, Kolarski, Mirko Manojlovic, additional, Kong, Keonho A., additional, Kshirsagar, Rijul S., additional, Lee, Joseph S., additional, Lin, Tian‐Yun, additional, McCormick, Justin P., additional, Melder, Katie, additional, Morse, Elliot, additional, Nguyen, Theodore V., additional, Norwood, Timothy G., additional, Pang, Jonathan C., additional, Parsel, Sean M., additional, Patel, Prayag S., additional, Ringel, Barak, additional, Schneider, Alexander L., additional, Spielman, Daniel B., additional, Spock, Todd, additional, and Vasudev, Milind, additional

Published
2023
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29. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1

Author

Clement, Mathew, primary, Ladell, Kristin, additional, Miners, Kelly L, additional, Marsden, Morgan, additional, Chapman, Lucy, additional, Cardus Figueras, Anna, additional, Scott, Jake, additional, Andrews, Robert, additional, Clare, Simon, additional, Kriukova, Valeriia V, additional, Lupyr, Ksenia R, additional, Britanova, Olga V, additional, Withers, David R, additional, Jones, Simon A, additional, Chudakov, Dmitriy M, additional, Price, David A, additional, and Humphreys, Ian R, additional

Published
2023
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34. Impact of Endoscopic Skull Base Surgery on Sleep and Cognitive Function.

Author

Aboueisha, Mohamed A., Popovici, Nadia Y., Ruzevick, Jacob, Emerson, Sam, Ferreira, Manuel, Lehmann, Ashton E., Abuzeid, Waleed M., Humphreys, Ian M., and Jafari, Aria

Subjects
SKULL base, SKULL surgery, COGNITIVE ability, SLEEP interruptions, RHINORRHEA, SLEEP quality, CEREBROSPINAL fluid leak
Abstract

This article, published in the Journal of Neurological Surgery, explores the impact of endoscopic skull base surgery (ESBS) on sleep quality and cognitive function. The study conducted a retrospective cohort analysis of patients who underwent ESBS at an academic center. Patient-reported outcome measures were used to assess sleep quality and cognitive function before and after surgery. The results showed that patient-reported sleep quality worsened in the immediate postoperative period but improved over time. Cognitive function did not exhibit significant differences. The study suggests that factors such as anesthesia, hospitalization, and disrupted sleep patterns may contribute to sleep disturbance following ESBS. The findings have practical implications for preoperative counseling and managing patient expectations. [Extracted from the article]

Published
2024
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36. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion.

Author

Whiteside, Sarah K., Grant, Francis M., Alvisi, Giorgia, Clarke, James, Tang, Leqi, Imianowski, Charlotte J., Zhang, Baojie, Evans, Alexander C., Wesolowski, Alexander J., Conti, Alberto G., Yang, Jie, Lauder, Sarah N., Clement, Mathew, Humphreys, Ian R., Dooley, James, Burton, Oliver, Liston, Adrian, Alloisio, Marco, Voulaz, Emanuele, and Langhorne, Jean

Subjects
T cells, IMMUNITY, IMMUNOTHERAPY, IMMUNE response, IMMUNOSUPPRESSION, TREATMENT failure, TREATMENT effectiveness
Abstract

Regulatory T (Treg) cells contribute to immune homeostasis but suppress immune responses to cancer. Strategies to disrupt Treg cell–mediated cancer immunosuppression have been met with limited clinical success, but the underlying mechanisms for treatment failure are poorly understood. By modeling Treg cell–targeted immunotherapy in mice, we find that CD4+ Foxp3− conventional T (Tconv) cells acquire suppressive function upon depletion of Foxp3+ Treg cells, limiting therapeutic efficacy. Foxp3− Tconv cells within tumors adopt a Treg cell–like transcriptional profile upon ablation of Treg cells and acquire the ability to suppress T cell activation and proliferation ex vivo. Suppressive activity is enriched among CD4+ Tconv cells marked by expression of C-C motif receptor 8 (CCR8), which are found in mouse and human tumors. Upon Treg cell depletion, CCR8+ Tconv cells undergo systemic and intratumoral activation and expansion, and mediate IL-10–dependent suppression of antitumor immunity. Consequently, conditional deletion of Il10 within T cells augments antitumor immunity upon Treg cell depletion in mice, and antibody blockade of IL-10 signaling synergizes with Treg cell depletion to overcome treatment resistance. These findings reveal a secondary layer of immunosuppression by Tconv cells released upon therapeutic Treg cell depletion and suggest that broader consideration of suppressive function within the T cell lineage is required for development of effective Treg cell–targeted therapies. Editor's Summary: Regulatory T (Treg) cells have immunosuppressive properties, which has led to the development of Treg cell–depleting cancer immunotherapies. Targeted Treg cell depletion has had limited clinical efficacy, and Whiteside et al. examined the underlying mechanism of treatment failure using a mouse model of Treg cell–targeted immunotherapy. Upon Treg cell depletion, intratumoral CD4+ Foxp3− conventional T (Tconv) cells acquired Treg cell transcriptional characteristics and assumed immunosuppressive properties as measured ex vivo. Depletion of Treg cells caused expansion of CCR8-expressing Tconv cells, which drove IL-10–mediated suppression of antitumor immunity. Consequently, resistance to Treg cell depletion could be prevented through conditional deletion of Il10 in T cells or cotreatment with antibodies that block IL-10 signaling. These findings highlight multiple layers of immunosuppression that can be overcome to unleash cancer immunotherapy efficacy. —Christiana Fogg [ABSTRACT FROM AUTHOR]

Published
2023
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38. Genetic manipulation of candidate phyla radiation bacteria provides functional insights into microbial dark matter

Author

Wang, Yaxi, primary, Gallagher, Larry A., additional, Andrade, Pia A., additional, Liu, Andi, additional, Humphreys, Ian R., additional, Turkarslan, Serdar, additional, Cutler, Kevin J., additional, Arrieta-Ortiz, Mario L., additional, Li, Yaqiao, additional, Radey, Matthew C., additional, McLean, Jeffrey S., additional, Cong, Qian, additional, Baker, David, additional, Baliga, Nitin S., additional, Peterson, S. Brook, additional, and Mougous, Joseph D., additional

Published
2023
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39. Long‐term quality of life after treatment in sinonasal malignancy: A prospective, multi‐center study

Author

Maoz, Sabrina L., primary, Wang, Eric W., additional, Hwang, Peter H., additional, Choby, Garret, additional, Kuan, Edward C., additional, Fleseriu, Cara M., additional, Chan, Erik P., additional, Adappa, Nithin D., additional, Geltzeiler, Mathew, additional, Getz, Anne E., additional, Humphreys, Ian M., additional, Le, Christopher H., additional, Abuzeid, Waleed M., additional, Chang, Eugene H., additional, Jafari, Aria, additional, Kingdom, Todd T., additional, Kohanski, Michael A., additional, Lee, Jivianne K., additional, Lazor, Jillian W., additional, Nabavizadeh, Ali, additional, Nayak, Jayakar V., additional, Palmer, James N., additional, Patel, Zara M., additional, Pinheiro‐Neto, Carlos D., additional, Resnick, Adam C., additional, Smith, Timothy L., additional, Snyderman, Carl H., additional, St. John, Maie A., additional, Storm, Phillip B., additional, Suh, Jeffrey D., additional, Wang, Marilene B., additional, Sim, Myung S., additional, and Beswick, Daniel M., additional

Published
2023
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40. Layperson Perception of Reflux‐Related Symptoms

Author

Fischer, Jakob L., primary, Tolisano, Anthony M., additional, Navarro, Alvaro I., additional, Trinh, Lily, additional, Abuzeid, Waleed M., additional, Humphreys, Ian M., additional, Akbar, Nadeem A., additional, Shah, Sharan, additional, Schneider, John S., additional, Riley, Charles A., additional, and McCoul, Edward D., additional

Published
2023
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41. Orbital resection by intranasal technique (ORBIT): A new classification system for reporting endoscopically resectable primary benign orbital tumors

Author

Jafari, Aria, primary, Adappa, Nithin D., additional, Anagnos, Vincent J., additional, Campbell, Raewyn G., additional, Castelnuovo, Paolo, additional, Chalian, Ara, additional, Chambers, Christopher B., additional, Chitguppi, Chandala, additional, Dallan, Iacopo, additional, El Rassi, Edward, additional, Freitag, Suzanne K., additional, Fernandez Miranda, Juan C., additional, Ferreira, Manuel, additional, Gardner, Paul A., additional, Gudis, David A., additional, Harvey, Richard J., additional, Huang, Qian, additional, Humphreys, Ian M., additional, Kennedy, David W., additional, Lee, John Y.K., additional, Lehmann, Ashton E., additional, Locatelli, Davide, additional, McKinney, Kibwei A., additional, Moreau, Annie, additional, Nyquist, Gurston, additional, Palmer, James N., additional, Prepageran, Narayanan, additional, Pribitkin, Edmund A., additional, Rabinowitz, Mindy R., additional, Rosen, Marc R., additional, Sacks, Raymond, additional, Sharma, Dhruv, additional, Snyderman, Carl H., additional, Tonya Stefko, S., additional, Stokken, Janalee K., additional, Wang, Eric W., additional, Workman, Alan D., additional, Wu, Arthur W., additional, Yu, Jen Y., additional, Zhang, Matthew M., additional, Zhou, Bing, additional, and Bleier, Benjamin S., additional

Published
2023
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44. Long‐term quality of life after treatment in sinonasal malignancy: A prospective, multicenter study.

Author

Maoz, Sabrina L., Wang, Eric W., Hwang, Peter H., Choby, Garret, Kuan, Edward C., Fleseriu, Cara M., Chan, Erik P., Adappa, Nithin D., Geltzeiler, Mathew, Getz, Anne E., Humphreys, Ian M., Le, Christopher H., Abuzeid, Waleed M., Chang, Eugene H., Jafari, Aria, Kingdom, Todd T., Kohanski, Michael A., Lee, Jivianne K., Lazor, Jillian W., and Nabavizadeh, Ali

Published
2023
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46. Layperson Perception of Symptoms Caused by the Sinuses

Author

Riley, Charles A., primary, Soneru, Christian P., additional, Navarro, Alvaro, additional, Trinh, Lily, additional, Abuzeid, Waleed M., additional, Humphreys, Ian M., additional, Akbar, Nadeem A., additional, Shah, Sharan, additional, Lee, Jivianne T., additional, Wu, Tara J., additional, Schneider, John S., additional, and McCoul, Edward D., additional

Published
2023
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50. A Targeted Amino Acid Mutation in Influenza a Virus Universal Epitope Transforms Immunogenicity and Protective Immunity via CD4 T Cell Activation

Author

Hulin-Curtis, Sarah Louise, primary, Geary, James, additional, MacLachlan, Bruce, additional, Altmann, Daniel, additional, Baillon, Laury, additional, Cole, David, additional, Greenshields-Watson, Alexander, additional, Hesketh, Sophie, additional, Humphreys, Ian R., additional, Jones, Ian, additional, Lauder, Sarah, additional, Mason, Georgina, additional, Smart, Kathryn, additional, Scourfield, Oliver, additional, Scott, Jake, additional, Sukhova, Ksenia, additional, Stanton, Richard J., additional, Wall, Aaron, additional, Rizkallah, Pierre, additional, Barclay, Wendy S., additional, Gallimore, Awen, additional, and Godkin, Andrew, additional

Published
2023
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