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Gene regulatory divergence between species can result from cis-acting local changes to regulatory element DNA sequences or global trans-acting changes to the regulatory environment. Understanding how these mechanisms drive regulatory evolution has been limited by challenges in identifying trans-acting changes. We present a comprehensive approach to directly identify cis- and trans-divergent regulatory elements between human and rhesus macaque lymphoblastoid cells using assay for transposase-accessible chromatin coupled to self-transcribing active regulatory region (ATAC-STARR) sequencing. In addition to thousands of cis changes, we discover an unexpected number (∼10,000) of trans changes and show that cis and trans elements exhibit distinct patterns of sequence divergence and function. We further identify differentially expressed transcription factors that underlie ∼37% of trans differences and trace how cis changes can produce cascades of trans changes. Overall, we find that most divergent elements (67%) experienced changes in both cis and trans, revealing a substantial role for trans divergence-alone and together with cis changes-in regulatory differences between species.

Genomic time series from experimental evolution studies and ancient DNA datasets offer us a chance to directly observe the interplay of various evolutionary forces. We show how the genome-wide variance in allele frequency change between two time points can be decomposed into the contributions of gene flow, genetic drift, and linked selection. In closed populations, the contribution of linked selection is identifiable because it creates covariances between time intervals, and genetic drift does not. However, repeated gene flow between populations can also produce directionality in allele frequency change, creating covariances. We show how to accurately separate the fraction of variance in allele frequency change due to admixture and linked selection in a population receiving gene flow. We use two human ancient DNA datasets, spanning around 5,000 y, as time transects to quantify the contributions to the genome-wide variance in allele frequency change. We find that a large fraction of genome-wide change is due to gene flow. In both cases, after correcting for known major gene flow events, we do not observe a signal of genome-wide linked selection. Thus despite the known role of selection in shaping long-term polymorphism levels, and an increasing number of examples of strong selection on single loci and polygenic scores from ancient DNA, it appears to be gene flow and drift, and not selection, that are the main determinants of recent genome-wide allele frequency change. Our approach should be applicable to the growing number of contemporary and ancient temporal population genomics datasets.

Understanding decision-making and strategy in international relations is enriched by an approach that takes into account different historical scales. Big History, which delves into the interplay of cultural, evolutionary, and cosmological processes, serves as a valuable tool in elucidating the strategic behavior of political actors. In a systemic setting where anticipatory capability stands as a paramount asset, this approach aids in pinpointing potential sources of disorder within the international arena. When policymakers seek to understand an interconnected web of actors, make informed decisions, and anticipate the actions of others, they draw on a complex set of mental tools. These tools combine cultural information with ethological cognitive archetypes, shaped by millions of years of natural selection in primate species and hardwired into the human collective unconscious. Cultural information, stemming from these archetypes, has the capacity to either augment or suppress the expression of these innate structures. At an unconscious level, the formation of ingroups is a socio-cognitive process enabling human agents to frame their relationships with ingroup members in prosocial and non-lethal terms. It acknowledges the presence of conflict for status and influence among ingroup members, yet ethological suppression mechanisms work to minimize the potential for lethal aggression, thereby preserving group cohesion. Hence, we posit that when systems of international relations are crafted to maintain the status quo between parties while simultaneously being founded on principles and institutions suggesting solidarity and cooperation, human policymakers may experience marginal cognitive dissonance at an unconscious level. Such cognitive dissonance, arising from these mixed signals, could incline policymakers to pursue policies contravening the terms of the system. While this phenomenon alone cannot solely account for systemic failure at the international level, it likely contributes to it. We suggest that policymakers engaged in diplomatic initiatives such as the Concert of Europe (1814-1815), the Washington Naval Treaty (1922) and the Nuclear Non-Proliferation Treaty (since 1970, and still in force), were (and continue to be) susceptible to this cognitive phenomenon on a regular basis.

The management of large common-pool resources, like fisheries and forests, is more difficult when more people and more communities can access them-a particular problem given increased population sizes, higher mobility and globalized trade in the Anthropocene. Social relationships spanning communities, such as kin relationships, business or trade relationships and friendships, can make management even more challenging by facilitating and transmitting norms of overharvesting. However, these long-distance relationships can also bolster management by transmitting norms for sustainability, promoting interdependence and laying the groundwork for nested management systems. Here, we review the negative and positive impacts of long-distance relationships on local natural resource management (NRM), providing illustrative examples from our field research on forest and fisheries management in Tanzania. Drawing on the evolutionary literature, the development literature and our field data, we offer suggestions for how development partners can avoid the pitfalls of long-distance relationships and how they can use or even deliberately foster long-distance relationships to promote successful local NRM. This article is part of the theme issue Evolution and sustainability: gathering the strands for an Anthropocene synthesis.

Complex structural variations (cxSVs) are often overlooked in genome analyses due to detection challenges. We developed ARC-SV, a probabilistic and machine-learning-based method that enables accurate detection and reconstruction of cxSVs from standard datasets. By applying ARC-SV across 4,262 genomes representing all continental populations, we identified cxSVs as a significant source of natural human genetic variation. Rare cxSVs have a propensity to occur in neural genes and loci that underwent rapid human-specific evolution, including those regulating corticogenesis. By performing single-nucleus multiomics in postmortem brains, we discovered cxSVs associated with differential gene expression and chromatin accessibility across various brain regions and cell types. Additionally, cxSVs detected in brains of psychiatric cases are enriched for linkage with psychiatric GWAS risk alleles detected in the same brains. Furthermore, our analysis revealed significantly decreased brain-region- and cell-type-specific expression of cxSV genes, specifically for psychiatric cases, implicating cxSVs in the molecular etiology of major neuropsychiatric disorders. [Display omitted] • ARC-SV uses machine learning on pangenomes to detect cxSVs with high accuracy • Rare cxSVs in the human population are enriched in neural genes • Rare cxSVs are enriched in loci that underwent rapid human-specific evolution • cxSVs contribute to the genetic architecture of major psychiatric disorders ARC-SV enables highly accurate detection and characterization of localized complex rearrangements of multiple DNA segments. Applying ARC-SV across human populations and brain cohorts uncovers connections between complex structural variantion and human-specific evolution, neural genes, and major psychiatric disorders. [ABSTRACT FROM AUTHOR]

Micro-society experimental setups are increasingly used to infer aspects of human behavioural evolution. A key part of human society today is our dependence on, and use of, technology–whether simple (such as a knife) or complex (such as the technology that underpins AI). Previously, two groups of researchers used an abstracted-wheel experiment to explore the evolution of human technical behaviour, reaching fundamentally different outcomes. Whereas one group saw their results as indicating social learning only (void of causal understanding), the other inferred non-social technical reasoning as part of human technical behaviour. Here we report on the third generation of the micro-society abstracted-wheel experiment. We argue that causal reasoning is inseparable from both social learning and technical reasoning, and that these traits probably co-evolved into the current human socio-technical niche. Based on our outcomes, we present a critical assessment of what this experiment may (or may not) reveal about the evolution of human technical behaviour. We show that the abstracted-wheel experiment reflects behavioural output only, instead of testing for cognition. It is therefore limited in its ability to inform on aspects of human cognitive evolution, but it can provide useful insights into the interrelatedness of social learning, technical reasoning, and causal reasoning. Such a co-evolutionary insight has the potential to inform on aspects of human socio-technical evolution throughout the Pleistocene. [ABSTRACT FROM AUTHOR]

Integrated assessment models (IAMs) are popular tools used to predict the evolution of human society, a challenging question that science has long tried to address. The World3 model is a popular IAM, designed in the seventies by several scientists convened by the Club of Rome and mostly known for its usage to analyze the so‐called limits to growth. The recent Earth for all (E4A) model has been initiated by one of the major co‐authors of the World3 model, Jørgen Randers. It is substantially more complicated than the relatively simple World3 model, and it has been used to compare two different and opposite world development scenarios: the too little too late scenario, in which current policies are assumed to continue, and the giant leap (GL) scenario, in which 21 policies related to five turnarounds are identified to produce significant improvements in six indicators of human well‐being. By using global and local sensitivity analyses of the E4A model, we suggest that the evolution of the six indicators in the GL scenario can be approximately reached by focusing on just six policies and three turnarounds (namely, the energy, the inequality, and the poverty turnarounds). The evolution of the six indicators can be even improved by investing “reasonably” more on three of these six policies and by keeping unchanged the remaining three. From a methodological point of view, we exploit both global (Sobol) and local sensitivity analyses to identify the policies that most influence the six indicators, and we subsequently execute a scenario analysis of the identified policies to confirm that they can produce a similar (or even a better) evolution of the indicators themselves. [ABSTRACT FROM AUTHOR]

In current research on the Anthropocene, assessing the impact of human activities via stratigraphic records of sediments and demarcating the Anthropocene epoch globally are critical scientific issues that urgently need to be addressed. The northeastern Qinghai-Xizang Plateau (QXP), where humans first settled permanently in large numbers in the QXP, has varying sedimentary environments that are extremely sensitive to human activities. In contrast to other regions of the QXP, the northeastern sector boasts a richer array of climatic and environmental reconstruction sequences. This distinctive feature renders it an exemplary locale for investigating the stratigraphic boundary of the Anthropocene. Through in-depth analysis and integration of existing paleoclimate and paleoenvironment sequences in the northeastern QXP, we draw the following conclusions: (1) Throughout the past millennium, the impact of human activities on the environment of the northeastern QXP has become increasingly significant, especially in the past 200–300 years, gradually overshadowing climatic factors. (2) Since AD 1950, multiple physicochemical indicators related to human activities in the northeastern QXP have shown exponential growth, forming a distinct peak within the past millennium and clearly depicting the global "Great Acceleration" phenomenon and its development process. (3) Intensified human activities have driven swift environmental shifts and "decoupled" the interplay between climatic variations and the ecological environment, propelling the northeastern QXP into the "Early Anthropocene" from the "Late Holocene". On the basis of the above findings, we construct a model suitable for identifying the stratigraphic boundary of the Anthropocene in the northeastern QXP and note that since the ecological environment in the northeastern QXP has entered the "Early Anthropocene", the climate signals of certain physicochemical indicators in sediments are gradually becoming weaker, whereas the signals of human activities are becoming stronger. [ABSTRACT FROM AUTHOR]

Understanding the impact that climate had in shaping cranial variation is critical for inferring the evolutionary mechanisms that played a role in human diversification. Here, we provide a comprehensive study aiming to analyze the association between climate and cranial variation of high latitude populations living in temperate to cold environments of Asia, North America, and South America. For this, we compiled a large morphometric dataset (N = 2633), which was combined with climatic and genomic data. We tested the influence of climate on the facial skeleton, nasal protrusion, and cranial vault and through multiple statistical tests at two geographical scales: intracontinental and intercontinental. We show that populations living in cold areas share a morphological pattern characterized by an increase in nasal height, facial and orbital heights and widths, a decrease in facial protrusion, and larger, longer, and lower cranial vaults. There are also distinctive features; populations from north Asia present the tallest noses, largest faces, and cranial vaults of the whole sample. Nasal breadth dimensions show small values in Asians, large values in South Americans, and non‐significant changes in arctic North America. The morphological pattern in populations living at high latitude may be the result of parallel adaptation, as supported by physiological, morphometric, ecological, and genetic explanations, while the differences in magnitude and phenotypic expression could be due to the diverse population histories, severity of climate, and cultural strategies. Overall, our study shows that climate is a relevant factor shaping modern human morphology and it should be considered when studying modern human evolution and diversification. [ABSTRACT FROM AUTHOR]

The human brain's complex morphology is spatially constrained by numerous intrinsic and extrinsic physical interactions. Spatial constraints help to identify the source of morphological variability and can be investigated by employing anatomical network analysis. Here, a model of human craniocerebral topology is presented, based on the bony elements of the skull at birth and a previously designed model of the brain. The goal was to investigate the topological components fundamental to the craniocerebral geometric balance, to identify underlying phenotypic patterns of spatial arrangement, and to understand how these patterns might have influenced the evolution of human brain morphology. Analysis of the craniocerebral network model revealed that the combined structure of the body and lesser wings of the sphenoid bone, the parahippocampal gyrus, and the parietal and ethmoid bones are susceptible to sustain and apply major spatial constraints that are likely to limit or channel their morphological evolution. The results also showcase a high level of global integration and efficient diffusion of biomechanical forces across the craniocerebral system, a fundamental aspect of morphological variability in terms of plasticity. Finally, community detection in the craniocerebral system highlights the concurrence of a longitudinal and a vertical modular partition. The former reflects the distinct morphogenetic environments of the three endocranial fossae, while the latter corresponds to those of the basicranium and calvaria. [ABSTRACT FROM AUTHOR]

Copyright of Trans/Form/Ação is the property of Trans/Form/Acao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The impact of handedness on neural substrates of common tool processing and tool use skills as proxies to the mechanisms underlying modern reciprocal relationships among humans and their brains, the tools they create and use, and technologies they implement and utilise, has only recently started to be elucidated. Yet, as most of the reports on lateralisation of such processing or skills focused on a single task, and sharp divisions of participants into right-, left-, and mixed-handed, or non-righthanded for the latter two groups combined, little is known about interrelationships between the neuronal underpinnings of different skilled manual actions—e.g., manual praxis skills in the form of disparate hand-tool interactions, including their most common neural phenotypes in the population at large. Here, in 62 individuals with different handedness status, we studied the laterality of two praxic abilities involving common tools. Even though their neural substrates were expected to be closely linked, we identified numerous cases (in 7/28 righthanders [RH] – 25%, and in 6/21 lefthanders [LH] – 29% of participants) with hemispheric dissociations in the underlying mechanisms. They involved both right-lateralised functional grasp planning vs. left-lateralised visual tool use (8% of all tested cases, 3/28 RH: ~11%, and 2/21 LH: ~10%), and vice versa (13% of all cases, 4/28 RH: ~14%, and 4/21 LH: ~19% of participants). The laterality/organisation of these praxic skills was also compared to the laterality/organisation of productive language, with only few cases of dissociations identified. The observed phenotypes are discussed in the context of coevolutionary hypotheses linking ancient toolmaking and tool use skills, the associated cultural evolution, technological innovations, and language to the cortical expansion and functional lateralisation in human evolution. [ABSTRACT FROM AUTHOR]

Evolutionary changes in human brain structure and function have enabled our specialized cognitive abilities. How these changes have come about genetically and functionally has remained an open question. However, new methods are providing a wealth of information about the genetic, epigenetic, and transcriptomic differences that set the human brain apart. Combined with in vitro models that allow access to developing brain tissue and the cells of our closest living relatives, the puzzle pieces are now coming together to yield a much more complete picture of what is actually unique about the human brain. The challenge now will be linking these observations and making the jump from correlation to causation. However, elegant genetic manipulations are now possible and, when combined with model systems such as organoids, will uncover a mechanistic understanding of how evolutionary changes at the genetic level have led to key differences in development and function that enable human cognition. This perspective discusses the challenge of understanding what sets the human brain apart and proposes how the wealth of modern tools may allow for going from correlation to causation to understand the origins and biology behind human brain evolution. [ABSTRACT FROM AUTHOR]

In popular materials designed to teach American students about the evolution of human skin color, students are guided toward a model in which ancestral latitude predicts levels of skin pigmentation. While this model agrees with data from people whose ancestors practiced intensive agriculture in Europe, Asia, and Africa, this model does not match data from other human populations across the globe, including the predicted skin pigmentation of ancient hunter-gatherer populations who maintained long-term settlements in these same regions. In this review, we discuss findings from ancient genome sequencing and provide guidance on teaching an updated model on the evolution of human skin color. (To increase accessibility for non-specialists, we present here a targeted rationale for updating classroom teaching practices, with a set of frequently asked questions regarding the current state of scientific research on this topic addressed in supplemental material.) With this update, we hope to help students avoid common misconceptions about human evolution—particularly, that the evolutionary pressures encountered by those who adopted a single human culture would apply to all humans, everywhere—and leverage authentic data and argumentation to convey the anti-racist reality that people with a wide range of skin colors thrived in high-latitude regions for many thousands of years, just as students with a wide range of skin colors can thrive in whatever place they currently call home. [ABSTRACT FROM AUTHOR]

The human otolithic system (utricle and saccule), housed within the bony vestibule of the inner ear, establishes our sense of balance in conjunction with the semicircular canals. Yet, while the morphological evolution of the semicircular canals is actively explored, comparative morphological analyses of the otolithic system are lacking. This is regrettable because functional links with head orientation suggest the otolithic system could be used to track postural change throughout human evolution and across primates more broadly. In this context, we present the first analysis of the evolution of the human otolithic system within an anthropoid primate setting. Using the vestibule as a morphological proxy for the utricle and saccule, we compare humans to 13 other extant anthropoid species, and use phylogenetically-informed methods to find correlations with body size, endocranial flexion, and head-neck posture. Our results, obtained through micro-CT of 136 inner ears, reveal two major evolutionary transitions in hominoids, leading to distinctive vestibular morphology in humans, characterized by otolithic morphology resembling squirrel monkeys (possibly due to reversal), with a pronounced supraovalic fossa. Finally, we find a positional signal embedded in the anthropoid bony vestibule, providing the foundation to further explore the evolution of human head-neck posture using inner ear morphology. Morphometric modeling reveals evolutionary divergences of the otolithic inner ear in humans and apes, with a possible link to the evolution of postural behavior. [ABSTRACT FROM AUTHOR]

Leveraging the simplicity of nucleotide mismatch distributions, we provide an intuitive window into the evolution of the human influenza A 'nonstructural' (NS) gene segment. In an analysis suggested by the eminent Danish biologist Freddy B. Christiansen, we illustrate the existence of a continuous genetic "backbone" of influenza A NS sequences, steadily increasing in nucleotide distance to the 1918 root over more than a century. The 2009 influenza A/H1N1 pandemic represents a clear departure from this enduring genetic backbone. Utilizing nucleotide distance maps and phylogenetic analyses, we illustrate remaining uncertainties regarding the origin of the 2009 pandemic, highlighting the complexity of influenza evolution. The NS segment is interesting precisely because it experiences less pervasive positive selection, and departs less strongly from neutral evolution than e.g. the HA antigen. Consequently, sudden deviations from neutral diversification can indicate changes in other genes via the hitchhiking effect. Our approach employs two measures based on nucleotide mismatch counts to analyze the evolutionary dynamics of the NS gene segment. The rooted Hamming map of distances between a reference sequence and all other sequences over time, and the unrooted temporal Hamming distribution which captures the distribution of genotypic distances between simultaneously circulating viruses, thereby revealing patterns of nucleotide diversity and epi-evolutionary dynamics. [ABSTRACT FROM AUTHOR]

Before the increase in anthropogenic activities, the global coastal ocean was a net autotrophic system. From human activity and the evolution of the earth, changes have been generated in its continents, oceans, atmosphere and life. Transport of sediments and bioelements to the coastal zone has been drastically altered, and there is debate about whether this zone is autotrophic or heterotrophic. This work carried out an exploratory study of five sandy beaches in the central coastal area of the state of Veracruz, three urban beaches on a gradient of anthropogenic activities in the Metropolitan Zone of Veracruz (ZMV) and two natural, non-urbanized beaches far from the ZMV to determine the concentrations and biochemical characteristics of the heterotrophic bacterial groups found in samples of surface marine sediments during two contrasting seasons in the region: dry season and rainy season. The presence of heterotrophic bacteria reflected the degree of anthropogenic disturbance that each beach presents, with a tendency to concentrate mainly on those close to urban centers. On the other hand, the anthropogenic disturbance gradient did not influence the diversity of biochemical characteristics of heterotrophic bacteria. [ABSTRACT FROM AUTHOR]

Rotavirus A (RVA) is the main cause of acute gastroenteritis among children under the age of five globally. The unusual bat‐like human RVA strains G3P[10] (RVA/Human‐wt/THA/CMH079/05/2005/G3P[10] and RVA/Human‐wt/THA/CMH‐S015‐19/2019/G3P[10]) were detected in children with acute gastroenteritis in 2005 and 2019, respectively, in the same geographical area of Northern Thailand. To elucidate the genetic backgrounds of these unusual or bat‐like human RVA strains, the complete genome of these RVA strains was sequenced and phylogenetically analyzed. All eleven genome segments of these G3P[10] strains were genotyped as G3‐P[10]‐I8‐R3‐C3‐M3‐A9‐N3‐T3‐E3‐H6, which is closely related to bat G3P[10] RVA strain (RVA/Bat‐tc/CHN/MYAS33/2013/G3P[10]) and bat‐like human RVA strain (RVA/Human‐wt/THA/MS2015‐1‐0001/2015/G3P[10]). The findings indicate that human G3P[10] RVA strains detected in this study (RVA/Human‐wt/THA/CMH079/05/2005/G3P[10] and RVA/Human‐wt/THA/CMH‐S015‐19/2019/G3P[10]) contained all eleven genome segments similar to those of bat RVA strains and appeared to be human RVA strains of bat origin. Phylogenetic analysis revealed that several genome segments of these two RVA strains were also closely related with those of other species in addition to bats and had a zoonotic transmission history. The results of this study supported the roles of interspecies transmission of RVA strains among bats and humans in the natural environment and provided convincing evidence that the evolution of human RVAs was closely interrelated with those of animal RVAs. Continuing surveillance of RVAs in humans and animals is imperative to gain a better understanding of the origin and the evolution of these viruses. [ABSTRACT FROM AUTHOR]

The process of making stone tools, specifically knapping, is a hominin behaviour that typically involves using the upper limb to manipulate a stone hammer and apply concentrated percussive force to another stone, causing fracture and detachment of stone chips with sharp edges. To understand the emergence and subsequent evolution of tool-related behaviours in hominins, the connections between the mechanics of stone knapping, including the delivery of percussive forces, and biomechanics and hominin anatomy, especially in the upper limb, are required. However, there is an absence of direct experimental means to measure the actual forces generated and applied to produce flakes during knapping. Our study introduces a novel solution to this problem in the form of an ergonomic hand-held synthetic hammerstone that can record the percussive forces that occur during knapping experiments. This hammerstone is composed of a deformable pneumatic 3D-printed chamber encased within a 3D-printed grip and a stone-milled striker. During knapping, hammer impact causes the pneumatic chamber to deform, which leads to a change in pressure that is measured by a sensor. Comparisons of recorded pressure data against corresponding force values measured using a force plate show that the synthetic hammer quantifies percussion forces with relatively high accuracy. The performance of this hammerstone was further validated by conducting anvil-supported knapping experiments on glass that resulted in a root mean square error of under 6%, while recording forces up to 730 N with successful flake detachments. These validation results indicate that accuracy was not sensitive to variations up to 15° from the vertical in the hammer striking angle. Our approach allows future studies to directly examine the role of percussive force during the stone knapping process and its relationship with both anatomical and technological changes during human evolution. [ABSTRACT FROM AUTHOR]

While the human brain has evolved extraordinary abilities to dominate nature, modern living has paradoxically trapped it in a contemporary "cage" that stifles neuroplasticity. Within this modern environment lurk unseen natural laws with power to sustain the human brain's adaptive capacities - if consciously orchestrated into the environments we design. For too long our contemporary environments have imposed an unyielding static state, while still neglecting the brain's constant adaptive nature as it evolves to dominate the natural world with increasing sophistication. The theory introduced in this article aims to go back in nature without having to go back in time, introducing and expounding Neurosustainability as a novel paradigm seeing beyond the contemporary confines to architect environments and brains in parallel. Its integrated neuroevidenced framework proposes four enrichment scopes--spatial, natural, aesthetic, and social--each holding multifaceted attributes promising to sustain regions like the hippocampus, cortex and amygdala. Neurosustainability aims to liberate the quintessential essence of nature to sustain and enhance neuroplastic processes through a cycle that begins with design and extends through epigenetic changes. This paradigm shift aims to foster cognitive health and wellness by addressing issues like stress, depression, anxiety and cognitive decline common in the contemporary era thereby offering a path toward a more neurosustainable era aiming to nurture the evolution of the human brain now and beyond. [ABSTRACT FROM AUTHOR]

There's something strange about Freud's Civilization and its Discontents (1930). Biologically, Freud was a Neo-Lamarckian, who believed in both the modification of organisms through need and the inheritance of acquired characteristics. However, in Civilization, Freud argued that because human nature is immutable, society has dim odds of improving substantially. Lamarckians, of course, rejected that any species-nature is immutable, as species can always be transformed via the inheritance of acquired characteristics. In fact, many of Freud's Viennese contemporaries—such as Wilhelm Reich, Julius Tandler, and Paul Kammerer—took their Lamarckism to license precisely the sorts of radical social projects Freud deemed impossible. Thus the Freud of Civilization helped himself to a rigid view of human nature which, given his associated biological views, he seemingly ought to have rejected. In this paper, I explain this apparent inconsistency, and suggest Freud resolved it in the following way: Freud was not merely a Lamarckian, but also a strong and peculiar kind of recapitulationist, who believed stages of psychological development both recapitulate phylogeny, and "remain with us" throughout both individual lives and future species-history. I suggest Freud's recapitulationism supposed a certain inertia: what occurred in phylogenetic history cannot un-occur, and therefore there are aspects of our nature which we cannot un-acquire. In this way, Freud reached a rigid conception of human nature despite his Lamarckism. [ABSTRACT FROM AUTHOR]

Starting with the emotional response of university students to Li Bai's poems after watching the film "The Longest Day in Chang'an", this paper delves into the concept of entropy and the principle of entropy increase. By introducing the origin and significance of entropy, the paper aims to elucidate the contents and connections of the three laws of thermodynamics. It further explores the implications of the principle of entropy increase on both life and everyday living. The paper reveals that the entire history of human evolution and the development of life is a narrative of combating entropy. To live a meaningful life, one must continuously strive against entropy, breaking free from comfort zones and maintaining self-discipline. [ABSTRACT FROM AUTHOR]

Spatial interactions among anatomical elements help to identify topological factors behind morphological variation and can be investigated through network analysis. Here, a whole‐brain network model of the chimpanzee (Pan troglodytes, Blumenbach 1776) is presented, based on macroanatomical divisions, and compared with a previous equivalent model of the human brain. The goal was to contrast which regions are essential in the geometric balance of the brains of the two species, to compare underlying phenotypic patterns of spatial variation, and to understand how these patterns might have influenced the evolution of human brain morphology. The human and chimpanzee brains share morphologically complex inferior‐medial regions and a topological organization that matches the spatial constraints exerted by the surrounding braincase. These shared topological features are interesting because they can be traced back to the Chimpanzee‐Human Last Common Ancestor, 7–10 million years ago. Nevertheless, some key differences are found in the human and chimpanzee brains. In humans, the temporal lobe, particularly its deep and medial limbic aspect (the parahippocampal gyrus), is a crucial node for topological complexity. Meanwhile, in chimpanzees, the cerebellum is, in this sense, more embedded in an intricate spatial position. This information helps to interpret brain macroanatomical change in fossil hominids. [ABSTRACT FROM AUTHOR]

Since the 19th century, the study of shell middens has played an important role in archaeological research. Shell midden and broader coastal archaeology have transformed our understanding of human relationships with aquatic habitats, demonstrating the importance of marine environments to human evolution and ecology, the colonization of islands and establishment of maritime trade networks, changing social and political dynamics, and a variety of other issues. During the past two decades, shell midden research has greatly increased, marking an exciting time for new discoveries and heightened collaboration with Indigenous communities. Several key research trends in shell midden archaeology during the past 10–15 years include research on site distribution and temporality, underwater archaeology, historical ecology, terraforming, landscape legacies, and community collaboration. These research trends demonstrate the ways in which shell midden archaeologists are shaping our understanding of the human past and environmental change around the world. [ABSTRACT FROM AUTHOR]

Piloerection (e.g., goosebumps) is an essential thermoregulatory and social signaling mechanism in non‐human animals. Although humans also experience piloerection—often being perceived as an indicator of profound emotional experiences—its comparatively less effective role in thermoregulation and communication might influence our capacity to monitor its occurrence. We present three studies (total N = 617) demonstrating participants' general inability to detect their own piloerection events and their lack of awareness that piloerection occurs with a similar frequency on multiple anatomical locations. Self‐reported goosebumps were more frequent than observed piloerection. However, only 31.8% of self‐reports coincided with observable piloerection, a bias unrelated to piloerection intensity, anatomical location, heart‐rate variability, or interoceptive awareness. We also discovered a self‐report bias for the forearm, contradicting the observation that piloerection occurs with equal frequency on multiple anatomical locations. Finally, there was low correspondence between self‐reports of being "emotionally moved" and observed piloerection. These counterintuitive findings not only highlight a disconnect between an obvious physiological response and our capacity for self‐monitoring, but they underscore a fascinating divergence between human and non‐human species. Although piloerection is vital in non‐human organisms, the connection between piloerection and psychological experience in humans may be less significant than previously assumed, possibly due to its diminished evolutionary relevance. This research reveals a striking dissociation between an obvious physiological response—piloerection—and human capacity for self‐perception. Although this highlights the limitations of relying on self‐report measures, it also underscores an important divergence between humans and non‐human species. We propose that the relation between piloerection and psychological experience in humans is less pronounced than in other species, potentially due to its diminished role in human evolution. [ABSTRACT FROM AUTHOR]

Litter size plays an essential role in mammalian evolution and is one of the most important factors determining whether an organism is deemed to have a 'slow' or 'fast' life history strategy. Humans are distinct in being classified as having slow life history yet bearing singletons who have completed relatively less growth than other ape neonates. Previous work has proposed that the ancestral primate gave birth to singletons. However, primate litter size has not yet been contextualized within a broad phylogenetic assessment of mammalian life history. We performed a comprehensive investigation of primate litter size using life history data for 155 primate species, and litter size data for an additional 791 boreoeutherian mammals. Litter size and life history traits have strong phylogenetic signal in primates (Pagel's lambda: 0.99, p < 0.001; Blomberg's K: 0.6311. p < 0.001), and litter size is significantly negatively correlated with gestation length (p < 0.001). Our data support that the last common ancestors of both primates and Haplorhini gave birth to multiples (litter size 1.7 and 1.6, respectively). We also find that singleton-bearing pregnancies evolved convergently in multiple primate lineages, including tarsiers and other haplorhines. This study contributes significantly to our understanding of life history and litter size in mammals, and we emphasize the utility of a callitrichid model for investigating the evolution of human reproduction. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Arqueologia is the property of Revista de Arqueologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The use of tools played a central role in human culture and evolution. Early studies with apes demonstrated the tool use; however, currently the works have focused on Platyrrhine, particularly capuchin monkeys. Blonde capuchin monkeys, Sapajus flavius, have been observed using sticks to fish for termites in the Atlantic Forest, where this species has been extensively studied. In this study, we presented the first evidence of stone tool use by the blonde capuchin monkeys, as well as the dimensions and weight of these tools. We gathered data from three areas of Caatinga dry forest where we discovered this new tool use among the species. The mean weight of the hammers was 475.7 g (± 142 SD). The mean height of the anvils was 48.3 cm (± 18.7 SD), while the mean surface area of the anvils was 1.2 m2 (± 0.4 SD). We identified fruits and/or nuts from three plant species—Prunus dulces, Cnidoscolus quercifolius, and Syagrus coronate—near the anvils at the study sites. Additionally, we passively observed six instances of stone tool use by blonde capuchin monkeys. Their use of stones to crack encased foods mirrored behaviors previously reported in Sapajus libidinosus, a species well known for using stone tools to exploit hard nuts. Our findings place blonde capuchin monkeys among the list of primates that utilize stones as tools, highlighting the species' adaptability in exploiting resources within the Caatinga. Long-term studies are essentials to comprehend the use pattern of stone tools (across both general and seasonal perspectives) and the influence of variables, such as fruit hardness, distance to watercourses, and fruit availability on the use of this technology by this primate. [ABSTRACT FROM AUTHOR]

Evolution is a fundamental part of biology and thus it is essential that biology preservice teachers understand and accept it. The relationship between knowledge and acceptance of evolution, and specifically human evolution, has not been fully investigated in Israel. We sought to learn about that relationship amongst Israeli Jewish religious preservice science teachers. Twenty-three religious preservice teachers answered knowledge questions before and after participating in a human evolution activity and completed an acceptance questionnaire (I-SEA). In addition, eleven of them were interviewed regarding their knowledge of evolution and four were interviewed regarding their acceptance of evolution a few months after participating in the activity. Our main findings were that the relationship between knowledge and acceptance of evolution was not always one-to-one. The preservice teachers whose evolution knowledge is high and have firm religious faith accept the theory of evolution and are willing and eager to teach it. In addition, preservice teachers might have made a shift in their understanding of human evolution and thus accepted human evolution more due to the activity. More teacher training and exposure to evolution content and pedagogy are needed so that when preservice teachers will become in-service teachers they will teach evolution without hesitance. [ABSTRACT FROM AUTHOR]

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Copyright of Kölner Zeitschrift für Soziologie und Sozialpsychologie ( KZfSS) is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

AbstractUncovering the collective behavior of flows among locations is critical to understanding the structure within an ever-changing spatial network. When a network evolves, there may exist subgraphs within which the internal flows generally follow a rule: the change rates of the flow weight are either collectively high or low. Classic network measures such as degree, clustering, and betweenness can be used to quantify the process of network evolution by profiling the overall characteristics over time. However, it remains challenging to elucidate how a spatial network is evolving without looking at structures where collective changes emerge. To bridge this gap, we introduce the concept of the Collective Flow-Evolutionary Pattern (CFEP) as a mesoscopic description for spatial network evolution. Four types of patterns with distinct features are defined to clarify the collective behaviors of the flow-evolutionary characteristics. We provide an analytical framework that utilizes flow change rates between two snapshots of the spatial network to detect CFEPs as optimized flow evolution (evo-groups). Synthetic experiments are presented to validate the method. A case study of large-scale individual mobile positioning data is conducted in the Twin Cities Metropolitan Area, Minnesota, US to demonstrate how CFEP can effectively understand the evolution of human mobility networks. [ABSTRACT FROM AUTHOR]

Background: Some of the most consistent factors associated with college students' evolution acceptance are how much they know about evolution (understanding), and the extent to which they identify as religious (religiosity). However, few studies explore how the relationship between understanding and acceptance can be impacted by student religiosity levels. Further, students show different levels of acceptance of evolution depending on the scale of evolution and context of evolution, but few studies explore how evolution understanding is related to acceptance at different scales and in different contexts. In this study, we analyzed survey responses from 11,409 college biology students sampled from across the United States. Using linear mixed models, we explored the relationship between students' understanding and acceptance of evolution and how their religiosity impacted that relationship. We also explored how these relationships changed based on scale and context of evolution. Results: We found evidence of six different scales or contexts of evolution ranging from acceptance of microevolution to accepting that all life on Earth shares a common ancestor. We found that students were most likely to accept microevolution while they were the least likely to accept the common ancestry of life. Interactions between student religiosity and understanding of evolution were significant predictors of their acceptance of macroevolution, human evolution within the species, human common ancestry with other apes, and the common ancestry of life. Notably, among highly religious students, how much they understood about evolution was not related to how much they accepted the common ancestry of life. Conclusions: This study provides evidence for six different scales or contexts of evolution for which college students have different levels of acceptance. Students accepted the common ancestry of life the least indicating that this might be important to expand upon in future research. Further, we provide evidence that the relationship between evolution acceptance and understanding depends on scale and context of evolution as well as student religiosity levels. These results indicate that acceptance of evolution among college students is more multifaceted than previously thought and that highly religious students may find it particularly difficult to translate their understanding of evolution to their acceptance. [ABSTRACT FROM AUTHOR]

Objectives: Homo naledi is near the extreme of small brain size within Homo but is easily recognized as Homo in other aspects of endocast morphology. This study adds new evidence of the endocast morphology of H. naledi by describing the Lesedi Hominin 1 (LES1) endocranium from the Lesedi Chamber and compares it to the previously known H. naledi individual Dinaledi Hominin 3 (DH3) as well as other hominin taxa. Materials and Methods: We examined interlandmark distances with both univariate and multivariate methods in multiple hominin taxa and both species of Pan. For each distance, we compared groups using adjusted Z‐scores (Azs). Our multivariate analyses included both principal component analyses (PCA) and linear discriminant analyses (LDA). Results: DH3 and LES1 each have absolute third frontal convolution measures that enter the upper half of the variation for Homo sapiens, Homo erectus, and Homo neanderthalensis. Examined relative to the cube root of endocranial volume, H. naledi ranks among the highest values in these samples of Homo. Both absolute and relative values for H. naledi specimens are far above Pan, Australopithecus, and Paranthropus, suggesting an expanded Broca's area. Conclusions: Both qualitative and quantitative analyses show consistency between LES1 and other H. naledi endocasts and confirm the shared morphology of H. naledi with H. sapiens, H. neanderthalensis, and some specimens of H. erectus. [ABSTRACT FROM AUTHOR]

Although repetitive DNA forms much of the human genome, its study is challenging due to limitations in assembly and alignment of repetitive short-reads. We have deployed k-Seek , software that detects tandem repeats embedded in single reads, on 2,504 human genomes from the 1,000 Genomes Project to quantify the variation and abundance of simple satellites (repeat units <20 bp). We find that the ancestral monomer of Human Satellite 3 makes up the largest portion of simple satellite content in humans (mean of ∼8 Mb). We discovered ∼50,000 rare tandem repeats that are not detected in the T2T-CHM13v2.0 assembly, including undescribed variants of telomericand pericentromeric repeats. We find broad homogeneity of the most abundant repeats across populations, except for AG-rich repeats which are more abundant in African individuals. We also find cliques of highly similar AG- and AT-rich satellites that are interspersed and form higher-order structures that covary in copy number across individuals, likely through concerted amplification via unequal exchange. Finally, we use pericentromeric polymorphisms to estimate centromeric genetic relatedness between individuals and find a strong predictive relationship between centromeric lineages and pericentromeric simple satellite abundances. In particular, ancestral monomers of Human Satellite 2 and Human Satellite 3 abundances correlate with clusters of centromeric ancestry on chromosome 16 and chromosome 9, with some clusters structured by population. These results provide new descriptions of the population dynamics that underlie the evolution of simple satellites in humans. [ABSTRACT FROM AUTHOR]

Behavioural economics works toward more realistic accounts of economic action, which includes efforts to endogenise the 'social'. In its social strand, behavioural economics is specifically concerned with fair outcomes in interactive economic games, which are explained by reference to social preferences, norms and institutions. While these concepts also matter to scholars in political economy and socioeconomics, behavioural economists seek to go further in specifying their behavioural and evolutionary foundations. This article critically evaluates evolutionary research strategies in the social strand of behavioural economics, which aim to uncover the evolutionary origins of fairness in economic experiments. Representatives of this field offer new support for the classical idea of 'doux commerce', or the civilising function of markets, by suggesting that cooperation with strangers in economic exchange fundamentally shaped the course of human evolution. Their explanatory framework is gene-culture coevolution, which covers long timespans of human existence. However, the case for the virtuous effect of markets in human prehistory remains ambiguous: basic concepts, causal mechanisms, and timescales of analysis vary to an extent that it is possible to arrive at very different projections of 'doux commerce' into the past. With regard to the present, these fulfil a similar function in naturalising market moralities. [ABSTRACT FROM AUTHOR]

This article presents a bibliometric analysis of the current research landscape and future prospects in the field of elastomeric soft pneumatic actuators (ESPAs) inspired by the human hand. Drawing inspiration from the intricate mechanisms of the human hand, the study maps out the research landscape in the field of ESPAs, highlighting recent advancements and emerging trends. By analyzing the leading countries, institutions, authors, journals, funding bodies, citation patterns and intellectual structures, the article identifies emerging themes and research directions, shedding light on the evolution of human hand inspired ESPAs. Finally, the literature analysis is synthesized in the form of a list of research topics which could further extend the horizons of research on ESPAs. The findings of this bibliometric analysis offer valuable guidance for researchers, practitioners, and policymakers in understanding the current state of ESPA research and charting future research agendas. By synthesizing and visualizing the research landscape, the article aims to foster collaboration, innovation, and interdisciplinary exchange in the field of soft robotics and human-machine interaction. [ABSTRACT FROM AUTHOR]

One of the important signs that can be seen in the fundamental traditions of the world in the transition stage of a person to individuality is [passing through] a horizontal or vertical winding corridor (well/cave); a dark place full of fear and terror due to not being seen and unknown. Monsters, snakes and creatures of the underworld live in this place and can only be saved by fighting. Sometimes, in the depth of this scary place, there are obstacles that appear to be rewards or anything else pleasant, but the same object or situation, by creating suspense, is itself considered a test stage and sometimes an obstacle to victory. He will be a hero. In this article, the examples of suspension with the repeating pattern of "Hanging Man" in public and official literature of Iran and the world will be investigated. The result of the work shows that this image is rooted in the common essence of human attitude in facing life difficulties and according to the time and place of life and the type of human being, it is powerful in literature, culture and religion, art, politics and economy. It has continued its life. This image, influenced by the experience of disaster, which is the function of the human mind, and despite the cultural evolution of the human species, has not been removed from his mind, and was first reflected in the form of materialistic myths and rituals, and in modern times, by entering formal or general literary types, it has found a different function and created special literary types. [ABSTRACT FROM AUTHOR]

Lake sediments are ideal archives to evaluate the interactions between climatically driven environmental responses and human activity on seasonal to multi‐decadal timescales. This study focuses on the unique sediments of Diss Mere, the only lake in England providing an annually laminated (varved) record for most of the Holocene. We combine microfacies analysis with X‐ray core scanning data to explore the influence of natural and human‐led changes on sediment deposition over the past 10 200 years and evaluate the sensitivity of the lake sediments to climate variability through time. Variability of titanium (Ti), calcium (Ca) and silica (Si) explain most of the lithological changes observed in the sediment and we identify three stages with low (10 290–2070 cal a bp), intermediate (2070–1040 cal a bp) and intensified (1040 cal a bp – present) human influence. During the first stage, where varved sediments are preserved, Ti is low due to the minimal detrital input into the lake. Ca and Si during this stage reveal high‐amplitude variability responding to seasonal changes in sediment deposition. The termination of varved sediment preservation and increases in sedimentation rates coincide with a major rise in Ti after this first stage, marking the intensification of human activity around the lake. Ca is used here as an indicator of temperature‐included calcite precipitation, and the long‐term variability of the Ca profile resembles Holocene temperature evolution. This continues during periods of intensified human activity, suggesting that the Diss Mere sediments remain sensitive to climate through time. [ABSTRACT FROM AUTHOR]

This paper aims to place the general thesis for a species-unique “shared” or “we” intentionality, against the theoretical background of the material engagement approach. We will argue that the human ability to enact and share intentions rests upon a relational and participatory foundation of situated activity where intentional transactions between humans as well as between humans and things (in the broadest sense of material environment) are inseparable from the situational affordances of their engagement. Based on that, the paper advocates for an ecological-enactive account of shared intentionality which understands material engagement as central to the evolution and development of human social cognition. [ABSTRACT FROM AUTHOR]

Introduction: This study aims to investigate the impact of human activities on the evolution of coastal wetlands in the Liaohe River Delta. Understanding these impacts is crucial for the management, protection, and sustainable development of the ecological environment in the region. Methods: Quantitative analysis of the evolution of coastal wetlands along the Liaohe River from 1995 to 2020 using Landsat series remote sensing images. This study examines the changes in different landscapes and explores the impact of human activities on wetlands through methods such as land transfer matrix, landscape pattern index, and human activity hotspots. Results: The results show that the area of coastal wetlands in the Liaohe River Delta exhibited a fluctuating downward trend from 1995 to 2020. The eastern and western parts of the delta experienced greater disturbance to wetland landscapes due to human activities, while the northern and southern parts were mostly waters and reed lands with a smaller degree of human disturbance. Human activities have led to significant changes in farmland, ponds, rice paddies, construction land, and reed fields, thereby promoting the evolution of coastal wetlands. Discussion: This article discusses the characteristics of landscape pattern evolution in the study area, as well as the impact of human interference, economy, policies, and other factors on it, and compares it with the evolution patterns of other coastal wetlands in China. The changes in the landscape pattern of the study area are mainly reflected in the reduction and fragmentation of natural wetland areas, which are closely related to human activities, especially the development of construction and agriculture. The main economic manifestation is that the increase in land demand due to economic and urban development has led to the transformation of natural wetlands into construction land and other artificial landscapes. The implementation of regulations such as the Wetland Protection Law has contributed to the rational use and ecological restoration of wetlands, and also reflects the influence of policy factors. Compared with other studies, coastal wetlands in China generally face issues of degradation and loss, mainly caused by human activities, but also affected by natural factors such as rising sea levels, changes in coastlines, and climate change. [ABSTRACT FROM AUTHOR]

The Neolithic transition introduced major diet and lifestyle changes to human populations across continents. Beyond well‐documented bioarcheological and genetic effects, whether these changes also had molecular‐level epigenetic repercussions in past human populations has been an open question. In fact, methylation signatures can be inferred from UDG‐treated ancient DNA through postmortem damage patterns, but with low signal‐to‐noise ratios; it is thus unclear whether published paleogenomes would provide the necessary resolution to discover systematic effects of lifestyle and diet shifts. To address this we compiled UDG‐treated shotgun genomes of 13 pre‐Neolithic hunter‐gatherers (HGs) and 21 Neolithic farmers (NFs) individuals from West and North Eurasia, published by six different laboratories and with coverage c.1×–58× (median = 9×). We used epiPALEOMIX and a Monte Carlo normalization scheme to estimate methylation levels per genome. Our paleomethylome dataset showed expected genome‐wide methylation patterns such as CpG island hypomethylation. However, analyzing the data using various approaches did not yield any systematic signals for subsistence type, genetic sex, or tissue effects. Comparing the HG‐NF methylation differences in our dataset with methylation differences between hunter‐gatherers versus farmers in modern‐day Central Africa also did not yield consistent results. Meanwhile, paleomethylome profiles did cluster strongly by their laboratories of origin. Using larger data volumes, minimizing technical noise and/or using alternative protocols may be necessary for capturing subtle environment‐related biological signals from paleomethylomes. [ABSTRACT FROM AUTHOR]

The goal of Artificial Life research, as articulated by Chris Langton, is "to contribute to theoretical biology by locating life-as-we-know-it within the larger picture of life-as-it-could-be." The study and pursuit of open-ended evolution in artificial evolutionary systems exemplify this goal. However, open-ended evolution research is hampered by two fundamental issues: the struggle to replicate open-endedness in an artificial evolutionary system and our assumption that we only have one system (genetic evolution) from which to draw inspiration. We argue not only that cultural evolution should be seen as another real-world example of an open-ended evolutionary system but that the unique qualities seen in cultural evolution provide us with a new perspective from which we can assess the fundamental properties of, and ask new questions about, open-ended evolutionary systems, especially with regard to evolved open-endedness and transitions from bounded to unbounded evolution. Here we provide an overview of culture as an evolutionary system, highlight the interesting case of human cultural evolution as an open-ended evolutionary system, and contextualize cultural evolution by developing a new framework of (evolved) open-ended evolution. We go on to provide a set of new questions that can be asked once we consider cultural evolution within the framework of open-ended evolution and introduce new insights that we may be able to gain about evolved open-endedness as a result of asking these questions. [ABSTRACT FROM AUTHOR]

As we venture into 2025, the intersection of anthropology and technology presents a fascinating frontier for understanding humanity. This article explores the transformative impact of emerging technologies on our perceptions and experiences of being human. Anthropology, traditionally focused on the study of human societies, cultures, and evolutionary development, is now increasingly intertwined with the rapid advancements in technology. (Lytvynova, L. V. 2004) The article delves into the evolution of anthropological studies in the context of technological innovation. Historically, anthropology has provided insights into the cultural and social dynamics of human societies. However, the advent of digital technologies, artificial intelligence, and biotechnology is reshaping these dynamics, prompting anthropologists to reconsider their frameworks and methodologies. The integration of big data analytics, for instance, allows for a more nuanced understanding of human behavior on a global scale, uncovering patterns and trends that were previously elusive. Next, the article examines how technologies such as virtual reality (VR) and augmented reality (AR) are revolutionizing anthropological research and education. These immersive technologies enable researchers to recreate and explore ancient civilizations, offering new perspectives on historical and cultural contexts. Moreover, VR and AR provide powerful tools for education, allowing students to engage with anthropological content in more interactive and impactful ways. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Guangxi Normal University - Natural Science Edition is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A long-standing goal of evolutionary biology is to decode how changes in gene regulatory networks contribute to human-specific traits. Human accelerated regions (HARs) are prime candidates for driving gene regulatory modifications in human development. The RBFOX1 locus is densely populated with HARs, providing a set of potential regulatory elements that could have changed its expression in the human lineage. Here, we examined the role of RBFOX1-HARs using transgenic zebrafish reporter assays and identified 15 transcriptional enhancers that are active in the developing nervous system, 9 of which displayed differential activity between the human and chimpanzee sequences. The engineered loss of two selected RBFOX1-HARs in knockout mouse models modified Rbfox1 expression at specific developmental stages and tissues in the brain, influencing the expression and splicing of a high number of Rbfox1 target genes. Our results provided insight into the spatial and temporal changes in gene expression driven by RBFOX1-HARs. [ABSTRACT FROM AUTHOR]

Neandertais and Denisovans, having inhabited distinct regions in Eurasia and possibly Oceania for over 200,000 y, experienced ample time to adapt to diverse environmental challenges these regions presented. Among present-day human populations, Papua New Guineans (PNG) stand out as one of the few carrying substantial amounts of both Neandertal and Denisovan DNA, a result of past admixture events with these archaic human groups. This study investigates the distribution of introgressed Denisovan and Neandertal DNA within two distinct PNG populations, residing in the highlands of Mt Wilhelm and the lowlands of Daru Island. These locations exhibit unique environmental features, some of which may parallel the challenges that archaic humans once confronted and adapted to. Our results show that PNG highlanders carry higher levels of Denisovan DNA compared to PNG lowlanders. Among the Denisovan-like haplotypes with higher frequencies in highlander populations, those exhibiting the greatest frequency difference compared to lowlander populations also demonstrate more pronounced differences in population frequencies than frequency-matched nonarchaic variants. Two of the five most highly differentiated of those haplotypes reside in genomic areas linked to brain development genes. Conversely, Denisovan-like haplotypes more frequent in lowlanders overlap with genes associated with immune response processes. Our findings suggest that Denisovan DNA has provided genetic variation associated with brain biology and immune response to PNG genomes, some of which might have facilitated adaptive processes to environmental challenges. [ABSTRACT FROM AUTHOR]

Cumulative culture, the accumulation of modifications, innovations, and improvements over generations through social learning, is a key determinant of the behavioral diversity across Homo sapiens populations and their ability to adapt to varied ecological habitats. Generations of improvements, modifications, and lucky errors allow humans to use technologies and know-how well beyond what a single naive individual could invent independently within their lifetime. The human dependence on cumulative culture may have shaped the evolution of biological and behavioral traits in the hominin lineage, including brain size, body size, life history, sociality, subsistence, and ecological niche expansion. Yet, we do not know when, in the human career, our ancestors began to depend on cumulative culture. Here, we show that hominins likely relied on a derived form of cumulative culture by at least ~600 kya, a result in line with a growing body of existing evidence. We analyzed the complexity of stone tool manufacturing sequences over the last 3.3 My of the archaeological record. We then compare these to the achievable complexity without cumulative culture, which we estimate using nonhuman primate technologies and stone tool manufacturing experiments. We find that archaeological technologies become significantly more complex than expected in the absence of cumulative culture only after ~600 kya. [ABSTRACT FROM AUTHOR]