1. A non‐antibiotic organic coating on ZA6‐1 surface releasing different concentrations of sodium dodecyl sulphate/levulinic acid for orthopaedic application
- Author
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Feng Zou, Deren Zhao, Yangkai Liu, Qiqi Lu, Hulin Liu, Zilin Chen, Yaxing Fang, Xiaodong Tan, Yunjie Xiang, Xue Feng, Yongping Zhang, and Xi Rao
- Subjects
antibacterial ,biocompatibility ,biomaterials ,material property ,Biotechnology ,TP248.13-248.65 ,Biochemistry ,QD415-436 - Abstract
Abstract Bone implantation surgery is often accompanied by bacterial infection, resulting in infectious bone non‐union, pathological fracture and other serious consequences, which will aggravate the pain of patients. A non‐antibiotic coating consisting of sodium dodecyl sulphate (SDS) and levulinic acid (LA) with different concentrations was prepared by the authors on the zinc–aluminium alloy (ZA6‐1) using a wet chemistry treatment for orthopaedic application. The influence of SDS/LA concentrations on the surface morphology, composition and performance of the developed coating was investigated. The results showed that as‐prepared coating on a zinc alloy surface could improve the substrate's corrosion resistance and increase the degradation rate from 0.82 to 19.70 μm/year upon raising the SDS/LA concentration. Furthermore, higher hydrophilicity (100%) and morphology, as well as good cell adhesion and differentiation (ALP >95% for 7 days) were observed on coated zinc alloys. The increased SDS/LA concentration slightly weakens the biocompatibility and enhances the antibacterial performance of coated zinc alloys due to the synergistic effect of SDS/LA. Overall, the coating comprising 6 wt.% SDS and 9 wt.% LA showed excellent antibacterial action with a high level of biocompatibility, confirming its potential application for orthopaedic implants.
- Published
- 2024
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