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Abstract The weather conditions of the summer of 2022 were very unusual, particularly in Eastern Asia, Europe, and North America. The devasting impact of climate change has come to our attention, with much hotter and drier conditions, and with more frequent and intense flooding events. Some extreme events have reached a dangerous level, increasingly threatening human lives. The interconnected risks caused by these extreme disaster events are triggering a chain effect, forcing us to respond to these crises through changes in our living environment, which affect the atmosphere, the biosphere, the economy including the availability of energy, our cities, and our global society. Moreover, we have to confront the abnormal consequences of untypical, rapid changes of extreme events and fast switches between extreme states, such as from severe drought to devastating flooding. Recognizing this new situation, it is crucial to improve the adaptation capacity of our societies in order to reduce the risks associated with climate change, and to develop smarter strategies for climate governance. High-quality development must be science-based, balanced, safe, sustainable, and climate-resilient, supported by the collaborative governance of climate mitigation and adaptation. This article provides some recommendations and suggestions for resilience building and collaborative governance with respect to climate adaptation in response to a new planetary state that is characterized by more frequent and severe extreme weather events.

Abstract Knowledge of the chemical characteristics and sources of organic aerosols (OA) over marine is needed for evaluating their effects on climate change and air quality. Here, a quadrupole aerosol chemical speciation monitor (Q-ACSM) and a single-particle aerosol mass spectrometry (SPAMS) were synchronously employed to investigate the chemical composition, mixing state, and oxidation degree of oxidized organic aerosols (OOA) in PM1 over the East China Sea (ECS) from 3 to 27 June 2017. Both aerosol mass spectrometers demonstrated that a higher oxidation state of OOA in aerosol particles could be generated during marine air mass-dominated periods (MDP) than that generated during land air mass-dominated periods (LDP). Two OOA factors including semi-volatile oxidized organic aerosol (SV-OOA) and low-volatility oxidized organic aerosol (LV-OOA) were distinguished based on Q-ACSM. Fifty-seven percent of the total detected particles with obvious signals of organic markers were identified as oxidized organic carbon (OOC) particles via SPAMS and further divided into lower oxidized organic carbon (LOOC) particles and more oxidized organic carbon (MOOC) particles. All OOC-containing particles were clustered into seven particle subgroups. The EC and K subgroups dominated the LOOC and MOOC particles, respectively, during periods controlled by land air masses, indicating that notable OOC formation was influenced by continental sources. OOA with higher oxygen states were found to dominate near ports. This suggested that OOA chemical characteristics over the ESC are seriously affected by continental, ship, and port emissions, which should be synergistically considered in evaluating their effects on solar radiation transfer and cloud processes.

Abstract It is unequivocal that human influence has warmed the planet, which is seriously affecting the planetary health including human health. Adapting climate change should not only be a slogan, but requires a united, holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately. Recognizing the urgent needs to tackle the risk connection between climate change and One Health, the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided. Graphical Abstract

Abstract Chondrocyte differentiation is a critical process for endochondral ossification, which is responsible for long bone development and fracture repair. Considerable progress has been made in understanding the transcriptional control of chondrocyte differentiation; however, epigenetic regulation of chondrocyte differentiation remains to be further studied. NSD1 is a H3K36 (histone H3 at lysine 36) methyltransferase. Here, we showed that mice with Nsd1 deficiency in Prx1+ mesenchymal progenitors but not in Col2+ chondrocytes showed impaired skeletal growth and fracture healing accompanied by decreased chondrogenic differentiation. Via combined RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) analysis, we identified sex determining region Y box 9 (Sox9), the key transcription factor of chondrogenic differentiation, as a functional target gene of NSD1. Mechanistically, NSD1 regulates Sox9 expression by modulating H3K36me1 and H3K36me2 levels in the Sox9 promoter region, constituting a novel epigenetic regulatory mechanism of chondrogenesis. Moreover, we found that NSD1 can directly activate the expression of hypoxia-inducible factor 1α (HIF1α), which plays a vital role in chondrogenic differentiation through its regulation of Sox9 expression. Collectively, the results of our study reveal crucial roles of NSD1 in regulating chondrogenic differentiation, skeletal growth, and fracture repair and expand our understanding of the function of epigenetic regulation in chondrogenesis and skeletal biology.

Climate change is one of the biggest threats to human living and health in the 21st century. Whilst a large number of papers have been published addressing the health impact of climate change, there is a lack of comprehensive bibliometric analysis in the crosscutting field. This study evaluated the global scientific output of research in the field of climate change and health between 1990 and 2020, based on the Web of Science Core Collection database. Research themes were identified using a social network analysis technique based on author keywords. Research trends were assessed by the change in overall publication number and the percentage of publications in each research theme. Articles were further categorized by the availability of funding and author affiliation to compare the difference between developed and developing countries. Results showed that the research output in the field of climate change and health has increased dramatically in the past 30 years, mainly dominated by researchers in developed countries. The percentage of research receiving funding was found to be the lowest in those published by developing countries only and the highest in those published by the collaboration of developed and developing countries. A total of nine major research themes was identified. Research related to ‘risk assessment and adaptation’, ‘sustainable development’ and ‘infectious diseases’ were relatively underfunded. A significant research trend was observed between 2006 and 2020, with increased attention on research themes related to ‘risk assessment and adaptation’, ‘sustainable development’, ‘extreme events’ and ‘air pollution’, and reduced attention on research themes related to ‘ocean’, ‘infectious disease’ and ‘phenology’. The shift of the research trend was mainly driven by research in developed countries. Suggestions, recommendations and future priorities identified by experts in the field of atmospheric sciences, epidemiology, public health, climate change, environmental sciences, and policy development are also provided to guide future research. It is important to shift our focus from single health aspects to an integrated system (such as One Health framework, which considers environmental health, animal health and human health as a whole), with future research focusing more on the systemic impact of climate change in order to achieve better, more effective and efficient risk governance. More funding should be mobilized to support the research capacity building in developing countries and to support climate change adaptation strategies for sustainable development.

During the aging process, bone marrow mesenchymal stem cells (BMSCs) exhibit declined osteogenesis accompanied by excess adipogenesis, which will lead to osteoporosis. Here, we report that the H3 lysine 36 trimethylation (H3K36me3), catalyzed by histone methyltransferase SET-domain-containing 2 (SETD2), regulates lineage commitment of BMSCs. Deletion of Setd2 in mouse bone marrow mesenchymal stem cells (mBMSCs), through conditional Cre expression driven by Prx1 promoter, resulted in bone loss and marrow adiposity. Loss of Setd2 in BMSCs in vitro facilitated differentiation propensity to adipocytes rather than to osteoblasts. Through conjoint analysis of RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) data, we identified a SETD2 functional target gene, Lbp, on which H3K36me3 was enriched, and its expression was affected by Setd2 deficiency. Furthermore, overexpression of lipopolysaccharide-binding protein (LBP) could partially rescue the lack of osteogenesis and enhanced adipogenesis resulting from the absence of Setd2 in BMSCs. Further mechanistic studies demonstrated that the trimethylation level of H3K36 could regulate Lbp transcriptional initiation and elongation. These findings suggest that H3K36me3 mediated by SETD2 could regulate the cell fate of mesenchymal stem cells (MSCs) in vitro and in vivo, indicating that the regulation of H3K36me3 level by targeting SETD2 and/or the administration of downstream LBP may represent a potential therapeutic way for new treatment in metabolic bone diseases, such as osteoporosis.

Fate and seasonal variations of α-hexachlorocyclohexane (α-HCH) were simulated using a dynamic fugacity model in Lake Chaohu, China. Sensitivity analyses were performed to identify influential parameters and Monte Carlo simulation was conducted to assess model uncertainty. The calculated and measured values of the model were in good agreement except for suspended solids, which might be due to disregarding the plankton in water. The major source of α-HCH was an input from atmospheric advection, while the major environmental outputs were atmospheric advection and sediment degradation. The net annual input and output of α-HCH were approximately 0.294 t and 0.412 t, respectively. Sediment was an important sink for α-HCH. Seasonal patterns in various media were successfully modeled and factors leading to this seasonality were discussed. Sensitivity analysis found that parameters of source and degradation were more important than the other parameters. The sediment was influenced more by various parameters than air and water were. Temperature variation had a greater impact on the dynamics of the model output than other dynamic parameters. Uncertainty analysis showed that the model uncertainty was relatively low but significantly increased in the second half of the simulation period due to the increase in the gas-water diffusion flux variability.

Based on source-specific saccharide tracers, the characteristic of biomass burning (BB) and biogenic emissions to saccharides was investigated in three rural sites at Lincang, where covered with 65 % of forest in the southwest border of China. The total saccharides accounted for 8.4 ± 2.7 % of OC, and 1.6 ± 0.6 % of PM2.5. The measured anhydrosugars accounted for 48.5 % of total saccharides, among which levoglucosan was the most dominant species. The high level of levoglucosan was both attributed to the local BB activities and biomass combustion smoke transported from the neighboring regions of Southeast Asia (Myanmar) and the northern Indian Peninsula. The measured mono (di) saccharides and sugar alcohols accounted for 24.9 ± 8.3 % and 26.6 ± 9.9 % of the total saccharides, respectively, were both proved to be mostly emitted by direct biogenic volatilization from plant materials/surface soils, rather than as byproducts of polysaccharides breakdown during BB processes. Five sources of saccharides were resolved by non-negative matrix factorization (NMF) analysis, including BB, soil microbiota, plant senescence, airborne pollen and plant detritus with the contribution of 34.0 %, 16.0 %, 21.0 %, 23.7 % and 5.3 %, respectively. The results provide the information on the magnitude of levoglucosan and contributions of BB, as well as the characteristic of biogenic saccharides, at the remote sites of Southwest China, which can be further applied to regional source apportionment models and global climate models. [ABSTRACT FROM AUTHOR]