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5 results on '"Huilan Xiong"'

2. Tandem C–N coupling/Boulton–Katritzky rearrangement reactions of 3-aminoisoxazoles or 1,2,4-oxadiazol-3-amines with 2-pyridyl trifluoromethanesulfonate: a rapid access to [1,2,4]triazolo[1,5-a]pyridines

Author

Huilan Xiong, Zihao Li, Huang Tang, Lei He, and Wei Zhou

Subjects
Organic Chemistry
Abstract

A palladium-catalyzed tandem C–N coupling/BK rearrangement reaction of 1,2,4-oxadiazol-3-amines or 3-aminoisoxazoles with 2-pyridyl trifluoromethanesulfonate has been achieved for the first time.

Published
2022
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4. Asymmetric Synthesis of Spiro[Azetidine‐3,3′‐Indoline]‐2,2′‐Diones via Copper(I)‐Catalyzed Kinugasa/C−C Coupling Cascade Reaction

Author

Xianqiang Zhong, Meirong Huang, Huilan Xiong, Yuzhen Liang, Wei Zhou, and Qian Cai

Subjects
Indoles, Azetidines, General Medicine, General Chemistry, Copper, Catalysis
Abstract

Spiro[azetidine-indolines] are important scaffolds in diverse bioactive compounds. Current efforts to synthesize spiro[azetidine-indolines] are limited to chiral spiro[azetidine-2,3'-indolines]. Asymmetric synthesis of structurally similar chiral spiro[azetidine-3,3'-indolines] remains unexplored. In this work, the first copper(I)-catalyzed asymmetric Kinugasa/aryl C-C coupling cascade reaction is described. This provides a straightforward access to densely functionalized chiral spiro[azetidine-3,3'-indoline]-2,2'-diones in good yields and with high enantioselectivity.

Published
2022
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5. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro

Author

Yifan, Ouyang, Hongfei, Si, Chengjun, Zhu, Liang, Zhong, Haowen, Ma, Zongyang, Li, Huilan, Xiong, Tongzheng, Liu, Zhong, Liu, Zhang, Zhang, Zhi-Min, Zhang, and Qian, Cai

Subjects
Mice, Structure-Activity Relationship, Neoplasms, Animals, Humans, Protein Kinase Inhibitors
Abstract

RIOK2 is an atypical kinase implicated in multiple human cancers. Although recent studies establish the role of RIOK2 in ribosome maturation and cell cycle progression, its biological functions remain poorly elucidated, hindering the potential to explore RIOK2 as a therapeutic target. Here, we report the discovery of

Published
2022

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