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Building livable urban space is an important component of urban construction. The evaluation of urban space livability is of great significance for urban sustainable development. The study measured the level of urban spatial livability in the urban area of Hefei from the spatial perspective of production-living-ecological space (PLES), using spatial analysis methods, to provide new ideas for the construction of livable urban spatial and to promote the coordination of urban spatial elements and spatial optimization. Firstly, this study constructed the evaluation model for urban spatial livability from three perspectives: Comfortable living, convenient production and ecological health. Secondly, using the evaluation model for urban spatial livability, the global spatial autocorrelation analysis method and the coupling coordination degree model, the single factor differentiation of urban space livable potential, comprehensive livable degree and the coupling degree of PLES in the urban area of Hefei were analyzed, respectively. Finally, this study discusses the coordination of PLES elements of the urban space in Hefei urban area, and puts forward spatial optimization strategies. The results show three important aspects of this system. (1) In terms of the single-factor livability of living, production and ecology, there are significant differences in the spatial distribution characteristics of the livability of the Hefei urban area. There is a spatial clustering of living comfort areas in the center, a spreading of production convenience areas from the center to the periphery, and a scattering of ecological health areas around the perimeter. (2) The overall livability of the urban space in Hefei is high. In terms of space, it shows the characteristics of high in the middle and low around the periphery, and the high-value area of livability is mainly concentrated in the urban center. (3) The coupling coordination degree of PLES in the urban area of Hefei is high in the city center and low around the city. The coupling coordination degree of life-production is the highest, which indicates that the spatial layout of these two elements has certain rationality and achieves benign coordination. [ABSTRACT FROM AUTHOR]

As a Second generation tyrosine kinase inhibitor (TKI), afatinib is approved to treat advanved/metastatic EGFR-mutant NSCLC (non-small cell lung cancer). However, the clinical application of afatinib is limited via acquired resistance. It has been revealed that CDK4/6 inhibitors hinder proliferation of cells and bring about differentiation as well as death of multiple malignant cells not only in vivo but also in vitro. Our research investigated whether a combination of Palbociclib with afatinib treatment was able to reverse acquired resistance with regard to NSCLC cells. The findings of our research demonstrated that combined Palbociclib and afatinib treatment exerted synergism in decreasing survival of cells with acquired resistance. Furthermore, combined Palbociclib with afatinib attenuated resistance that brings about recurrence of malignancies in xenografts with acquired resistance. In summary, the combination of Palbociclib and afatinib serves as an innovative strategy to reverse the acquired AR in pulmonary malignancies.