Search

Your search keyword '"Huijgens, P C"' showing total 477 results
Start Over Author "Huijgens, P C"
477 results on '"Huijgens, P C"'

2. Externally Controlled Studies Using Real-World Data in Patients With Hematological Cancers: A Systematic Review

Author

Hermans, Sjoerd J. F., van der Maas, Niek G., van Norden, Yvette, Dinmohamed, Avinash G., Berkx, Elizabeth, Huijgens, Peter C., Rivera, Donna R., de Claro, R. Angelo, Pignatti, Francesco, Versluis, Jurjen, and Cornelissen, Jan J.

Abstract

IMPORTANCE: The use of real-world data (RWD) external control arms in prospective studies is increasing. The advantages, including the immediate availability of a control population, must be balanced with the requirements of meeting evidentiary standards. OBJECTIVE: To address the question of whether and to what extent the methods of RWD studies compare to standard methods used in randomized clinical trials. EVIDENCE REVIEW: A systematic search across 4 electronic databases and Google Scholar was conducted from January 1, 2000, to October 23, 2023. Studies were included in the systematic review if they compared an intervention arm in a clinical trial to an RWD control arm in patients with hematological cancers and if they were published between 2000 and 2023. FINDINGS: Thirty-two prospective intervention studies incorporating external control data from RWD sources of patients with hematological cancers were identified. A total of 4306 patients from intervention arms and 10 594 from RWD control arms were included across all studies. Only 2 studies (6%) included prospectively collected RWD. The complete trial inclusion criteria were applied to the RWD cohort in 7 studies (22%). Four studies (13%) published the statistical analysis plan and prespecified use of RWD. A total of 23 studies (72%) applied matching algorithms for trial and RWD cohorts, including matching for demographic, disease, and/or therapy-related characteristics. The end point criteria were the same as the trial in 8 studies (25%). In contrast, 12 studies (38%) used different end points, and 12 (38%) did not provide an end point definition for the RWD. Twelve studies (38%) had a median follow-up difference of less than a year between arms. Eight studies (25%) reported toxic effect data for the trial arm, of which 5 studies reported toxic effect data for the RWD arm. CONCLUSIONS AND RELEVANCE: In this systematic review, limitations were observed in the application of clinical trial eligibility criteria to RWD, statistical rigor and application of matching methods, the definition of end points, follow-up, and reporting of adverse events, which may challenge the conclusions reported in studies using RWD.

Published
2024
Full Text
View/download PDF

24. Three cases of hearing impairment with surprising subjective improvements after prayer. What can we say when analyzing them?

Author

Kruijthoff, Dirk J., Bendien, Elena, van der Kooi, Cornelis, Glas, Gerrit, Abma, Tineke A., and Huijgens, Peter C.

Abstract

Aim: to enhance the understanding of documented mismatches between 'subjective' experiences and 'objective' data in three cases of self-reported instantaneous healing of hearing impairment upon prayer.Method: description of three cases taken out of a larger retrospective case-based study of prayer healing in the Netherlands. In this larger study multiple reported healings were investigated using both medical files and patients' narratives through in-depth interviews. A subset of three cases with dramatic subjective reduction of hearing impairment upon prayer was studied. These patients underwent extensive additional investigations at the audiology center of the Amsterdam University Medical Centre. All data was evaluated by an interdisciplinary medical assessment team, subsequent analysis was transdisciplinary.Results: the three case histories with self-reported healing after prayer demonstrated a clear mismatch between subjective experiences and objective findings. No measurable improvements were found in four different audiological testing methods. However, in-depth interviews, hetero-anamnesis and a validated questionnaire all confirmed the healings. The medical assessment team could not label these healings as 'medically remarkable' because of absence of measurable 'objective' changes, but they did consider them as 'remarkable in a broader sense'. On expert consultation no equivalents of mismatches to this extent could be found. The healing experiences of our participants involved their entire being with profound positive effects in different domains of their lives, and a perception of a benevolent God who acted upon them. There was a distinctive pattern, labelled by the participants as a healing of mind, soul and body.Conclusions: The subjective-objective incongruities that were found were not well understood. We noticed a paradox: the 'objective' measurements did not reflect hearing abilities in daily life where-as 'subjective experiential' data did. The latter could be 'objectified' and validated in various ways. In fact, a rigid distinction between 'objective' and 'subjective' was not relevant here, nor a hierarchy among them. A model leaving room for different causations (horizontal epistemology) complied best with the multi dimensionality we came across. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

47. Prospective Dutch colorectal cancer cohort : an infrastructure for long-term observational, prognostic, predictive and (randomized) intervention research

Author

Burbach, J P M, Kurk, S A, Coebergh van den Braak, R R J, Dik, V K, May, A M, Meijer, G. A., Punt, C J A, Vink, G R, Los, M, Hoogerbrugge, N, Huijgens, P C, Ijzermans, J N M, Kuipers, E J, de Noo, M E, Pennings, J P, van der Velden, A M T, Verhoef, C, Siersema, P D, van Oijen, M G H, Verkooijen, H M, Koopman, M, Burbach, J P M, Kurk, S A, Coebergh van den Braak, R R J, Dik, V K, May, A M, Meijer, G. A., Punt, C J A, Vink, G R, Los, M, Hoogerbrugge, N, Huijgens, P C, Ijzermans, J N M, Kuipers, E J, de Noo, M E, Pennings, J P, van der Velden, A M T, Verhoef, C, Siersema, P D, van Oijen, M G H, Verkooijen, H M, and Koopman, M

Published
2016

48. Prospective Dutch colorectal cancer cohort: an infrastructure for long-term observational, prognostic, predictive and (randomized) intervention research

Author

Onderzoek Radiotherapie, MS Medische Oncologie, MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Externen Med. Onco, Trialbureau Beeld, Circulatory Health, Epi Kanker Team A, Burbach, J P M, Kurk, S A, Coebergh van den Braak, R R J, Dik, V K, May, A M, Meijer, G. A., Punt, C J A, Vink, G R, Los, M, Hoogerbrugge, N, Huijgens, P C, Ijzermans, J N M, Kuipers, E J, de Noo, M E, Pennings, J P, van der Velden, A M T, Verhoef, C, Siersema, P D, van Oijen, M G H, Verkooijen, H M, Koopman, M, Onderzoek Radiotherapie, MS Medische Oncologie, MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Externen Med. Onco, Trialbureau Beeld, Circulatory Health, Epi Kanker Team A, Burbach, J P M, Kurk, S A, Coebergh van den Braak, R R J, Dik, V K, May, A M, Meijer, G. A., Punt, C J A, Vink, G R, Los, M, Hoogerbrugge, N, Huijgens, P C, Ijzermans, J N M, Kuipers, E J, de Noo, M E, Pennings, J P, van der Velden, A M T, Verhoef, C, Siersema, P D, van Oijen, M G H, Verkooijen, H M, and Koopman, M

Published
2016

49. Prospective Dutch colorectal cancer cohort: an infrastructure for long-term observational, prognostic, predictive and (randomized) intervention research

Author

Burbach, J. P. M., primary, Kurk, S. A., additional, Coebergh van den Braak, R. R. J., additional, Dik, V. K., additional, May, A. M., additional, Meijer, G. A., additional, Punt, C. J. A., additional, Vink, G. R., additional, Los, M., additional, Hoogerbrugge, N., additional, Huijgens, P. C., additional, Ijzermans, J. N. M., additional, Kuipers, E. J., additional, de Noo, M. E., additional, Pennings, J. P., additional, van der Velden, A. M. T., additional, Verhoef, C., additional, Siersema, P. D., additional, van Oijen, M. G. H., additional, Verkooijen, H. M., additional, and Koopman, M., additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results