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3 results on '"Hui-Jen Hsu"'

1. Association of Single‐Nucleotide Polymorphism 3 and c.553G>T ofAPOA5with Hypertriglyceridemia after Treatment with Highly Active Antiretroviral Therapy Containing Protease Inhibitors in HIV‐Infected Individuals in Taiwan

Author

Wen-Chun Liu, Mao-Yuan Chen, Jau-Tsuen Kao, Cheng-Hsin Wu, Sui-Yuan Chang, Hsin-Yun Sun, Szu-Min Hsieh, Chuan-Liang Kao, Wang-Huei Sheng, Lan-Yang Chang, Chien-Ching Hung, Hui-Jen Hsu, Shu-Fang Chang, Chun-Nan Lee, Shan-Chwen Chang, and Wei-Shin Ko

Subjects
Adult, Male, Microbiology (medical), medicine.medical_treatment, Taiwan, HIV Infections, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Young Adult, Pharmacotherapy, Acquired immunodeficiency syndrome (AIDS), Antiretroviral Therapy, Highly Active, medicine, Humans, Point Mutation, Protease inhibitor (pharmacology), Sida, Apolipoproteins A, Aged, Aged, 80 and over, Hypertriglyceridemia, Protease, biology, business.industry, Haplotype, HIV Protease Inhibitors, Middle Aged, medicine.disease, biology.organism_classification, Virology, Infectious Diseases, Haplotypes, Apolipoprotein A-V, Immunology, Female, business
Abstract

We investigated the relationship between hypertriglyceridemia and the single-nucleotide polymorphisms (SNPs) on APOA5 in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) in Taiwan. Receipt of protease inhibitor-based HAART, high baseline triglyceride levels, and carriage of APOA5 SNP3 or c.553G>T variants or APOA5 SNP1T/ SNP2G/SNP3C/c.553T haplotype were statistically significantly associated with development of extreme hypertriglyceridemia (triglyceride level, >500 mg/dL).

Published
2009
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3. Association of Single-Nucleotide Polymorphism 3 and c.553G1T of APOA5 with Hypertriglyceridemia after Treatment with Highly Active Antiretroviral Therapy Containing Protease Inhibitors in HIV-Infected Individuals in Taiwan.

Author

Sui-Yuan Chang, Wei-Shin Ko, Jau-Tsuen Kao, Lan-Yang Chang, Hsin-Yun Sun, Mao-Yuan Chen, Szu-Min Hsieh, Wang-Huei Sheng, Shu-Fang Chang, Wen-Chun Liu, Cheng-Hsin Wu, Hui-Jen Hsu, Chuan-Liang Kao, Chun-Nan Lee, Chien-Ching Hung, and Shan-Chwen Chang

Subjects
HYPERTRIGLYCERIDEMIA, GENETIC polymorphisms, HIV-positive persons, HIGHLY active antiretroviral therapy, ANTIVIRAL agents, THERAPEUTICS, PROTEASE inhibitors, TRIGLYCERIDES
Abstract

We investigated the relationship between hypertriglyceridemia and the single-nucleotide polymorphisms (SNPs) on APOA5 in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) in Taiwan. Receipt of protease inhibitor-based HAART, high baseline triglyceride levels, and carriage of APOA5 SNP3 or c.553G>T variants or APOA5 SNP1T/SNP2G/SNP3C/c.553T haplotype were statistically significantly associated with development of extreme hypertriglyceridemia (triglyceride level, >500 mg/dL). [ABSTRACT FROM AUTHOR]

Published
2009
Full Text
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