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262 results on '"Hui Junfeng"'

17. An Injectable Hydrogel System with Mild Photothermal Effects Combined with Ion Release for Osteosarcoma‐Related Bone Defect Repair.

Author

Yao, Jiaxin, He, Qiya, Zheng, Xiaoyan, Shen, Shihong, Hui, Junfeng, and Fan, Daidi

Subjects
PHOTOTHERMAL effect, CANCER relapse, BONE products, HYDROGELS, BONE cells, IONS
Abstract

Osteosarcoma, a common invasive malignant bone disease, presents therapeutic challenges due to the persistent problem of incomplete resection during surgical treatment. This often results in postoperative tumor recurrence and metastasis, and large‐scale bone defects are difficult to self‐repair, seriously affecting patient health. In this study, a dual‐ion doped organic‐inorganic composited SOH1(CP)1 injectable hydrogel system is successfully designed and constructed. This system consists of sericin protein grafted with hydrazide bonds, oxidized chondroitin sulfate, Se and Mg co‐doped HAp nanorods, and polydopamine‐coated CaO2 nanospheres. The system displays strong anti‐tumor activity due to its mild photothermal effects combined with the chemotherapeutic efficacy of SeO32−. Because the degradation behavior of hydrogel matches the bone repair cycle, including the nutritional support of hydrogel skeleton degradation products to promote bone cell proliferation, and the positive regulation of Ca2+, Mg2+, and PO43− released via the degradation of inorganic nanoparticles to promote bone differentiation, the system shows excellent bone defect repair efficacy. Importantly, this system achieves 100% tumor inhibition after 18 days, while ensuring complete bone repair after 12 weeks. Hence, the SOH1(CP)1 injectable hydrogel system, which displays both high anti‐osteosarcoma efficacy and strong bone repair properties, can serve as a new tool for osteosarcoma‐related bone defect repair. [ABSTRACT FROM AUTHOR]

Published
2024
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41. A Dual‐Kinetic Control Strategy for Designing Nano‐Metamaterials: Novel Class of Metamaterials with Both Characteristic and Whole Sizes of Nanoscale

Author

Xu, Guanhua, primary, Li, Mengmeng, additional, Wang, Qiyue, additional, Feng, Feng, additional, Lou, Qi, additional, Hou, Yi, additional, Hui, Junfeng, additional, Zhang, Peisen, additional, Wang, Li, additional, Yao, Li, additional, Qin, Shijie, additional, Ouyang, Xiaoping, additional, Wu, Dazhuan, additional, Ling, Daishun, additional, and Wang, Xiuyu, additional

Published
2022
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50. A Dual‐Kinetic Control Strategy for Designing Nano‐Metamaterials: Novel Class of Metamaterials with Both Characteristic and Whole Sizes of Nanoscale.

Author

Xu, Guanhua, Li, Mengmeng, Wang, Qiyue, Feng, Feng, Lou, Qi, Hou, Yi, Hui, Junfeng, Zhang, Peisen, Wang, Li, Yao, Li, Qin, Shijie, Ouyang, Xiaoping, Wu, Dazhuan, Ling, Daishun, and Wang, Xiuyu

Subjects
DEGREES of freedom, METAMATERIALS, ENERGY policy, MAGNETIC resonance imaging
Abstract

Increasingly intricate in their multilevel multiscale microarchitecture, metamaterials with unique physical properties are challenging the inherent constraints of natural materials. Their applicability in the nanomedicine field still suffers because nanomedicine requires a maximum size of tens to hundreds of nanometers; however, this size scale has not been achieved in metamaterials. Therefore, "nano‐metamaterials," a novel class of metamaterials, are introduced, which are rationally designed materials with multilevel microarchitectures and both characteristic sizes and whole sizes at the nanoscale, investing in themselves remarkably unique and significantly enhanced material properties as compared with conventional nanomaterials. Microarchitectural regulation through conventional thermodynamic strategy is limited since the thermodynamic process relies on the frequency‐dependent effective temperature, Teff(ω), which limits the architectural regulation freedom degree. Here, a novel dual‐kinetic control strategy is designed to fabricate nano‐metamaterials by freezing a high‐free energy state in a Teff(ω)‐constant system, where two independent dynamic processes, non‐solvent induced block copolymer (BCP) self‐assembly and osmotically driven self‐emulsification, are regulated simultaneously. Fe3+‐"onion‐like core@porous corona" (Fe3+‐OCPCs) nanoparticles (the products) have not only architectural complexity, porous corona and an onion‐like core but also compositional complexity, Fe3+ chelating BCP assemblies. Furthermore, by using Fe3+‐OCPCs as a model material, a microstructure‐biological performance relationship is manifested in nano‐metamaterials. [ABSTRACT FROM AUTHOR]

Published
2023
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