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2,453 results on '"Hui J."'

1. YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation

Author

Jian-Pu Zheng, Xiangqin He, Fang Liu, Shuping Yin, Shichao Wu, Maozhou Yang, Jiawei Zhao, Xiaohua Dai, Hong Jiang, Luyi Yu, Qin Yin, Donghong Ju, Claire Li, Leonard Lipovich, Youming Xie, Kezhong Zhang, Hui J. Li, Jiliang Zhou, and Li Li

Subjects
Medicine, Science
Abstract

Abstract Yin Yang 1 (YY1) regulates gene transcription in a variety of biological processes. In this study, we aim to determine the role of YY1 in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and in vitro. Here we show that vascular injury in rodent carotid arteries induces YY1 expression along with reduced expression of smooth muscle differentiation markers in the carotids. Consistent with this finding, YY1 expression is induced in differentiated VSMCs in response to serum stimulation. To determine the underlying molecular mechanisms, we found that YY1 suppresses the transcription of CArG box-dependent SMC-specific genes including SM22α, SMα-actin and SMMHC. Interestingly, YY1 suppresses the transcriptional activity of the SM22α promoter by hindering the binding of serum response factor (SRF) to the proximal CArG box. YY1 also suppresses the transcription and the transactivation of myocardin (MYOCD), a master regulator for SMC-specific gene transcription by binding to SRF to form the MYOCD/SRF/CArG box triad (known as the ternary complex). Mechanistically, YY1 directly interacts with MYOCD to competitively displace MYOCD from SRF. This is the first evidence showing that YY1 inhibits SMC differentiation by directly targeting MYOCD. These findings provide new mechanistic insights into the regulatory mechanisms that govern SMC phenotypic modulation in the pathogenesis of vascular diseases.

Published
2020
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2. Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

Author

Hui J. Wang, Chang Seok Lee, Rachel Sue Zhen Yee, Linda Groom, Inbar Friedman, Lyle Babcock, Dimitra K. Georgiou, Jin Hong, Amy D. Hanna, Joseph Recio, Jong Min Choi, Ting Chang, Nadia H. Agha, Jonathan Romero, Poonam Sarkar, Nicol Voermans, M. Waleed Gaber, Sung Yun Jung, Matthew L. Baker, Robia G. Pautler, Robert T. Dirksen, Sheila Riazi, and Susan L. Hamilton

Subjects
Science
Abstract

Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHS

Published
2020
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3. Measurements of a LYSO crystal array from threshold to 100 MeV

Author

Beesley, O., Carlton, J., Davis-Purcell, B., Ding, D., Foster, S., Frahm, K., Gibbons, L., Gorringe, T., Hertzog, D. W., Hochrein, S., Hui, J., Kammel, P., LaBounty, J., Liu, J., Roehnelt, R., Schwendimann, P., Soter, A., Swanson, E., and Taylor, B.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract

We report measurements of ten custom-made high-homogeneity LYSO crystals. The investigation is motivated by the need for a compact, high-resolution, and fast electromagnetic calorimeter for a new rare pion decay experiment. Each $2.5\times 2.5 \times 18$ cm$^3$ crystal was first characterized for general light yield properties and then its longitudinal response uniformity and energy resolution were measured using low-energy gamma sources. The ten crystals were assembled as an array and subjected to a 30 - 100 MeV positron beam with excellent momentum definition. The energy and timing resolutions were measured as a function of energy, and the spatial resolution was determined at 70 MeV. An additional measurement using monoenergetic 17.6 MeV gammas produced through a p-Li resonance was later made after the photosensors used in positron testing were improved. As an example of the results, the energy resolution at 70 MeV of 1.52 $\pm$ 0.03% is more than two times better than reported results using previous generation LYSO crystals., Comment: Minor editorial revision and additional table of manufacturer measurements

Published
2024

4. Effects of Peer Influences and Life-History Strategy on Chinese Junior High School Students’ Prosocial and Antisocial Behaviors

Author

Nan Zhu, Hui J. Lu, and Lei Chang

Subjects
adolescence, friendship, life history strategy, migrant students, peer influence, prosociality, Education (General), L7-991
Abstract

Peer influence and life-history strategy have been shown in previous research as facilitators of adolescents’ social conduct. The current research uses the data from a two-wave, nationally representative survey of Chinese junior high school students to examine how different aspects of peer influence and life-history strategy in Grade 7 might contribute to prosocial and antisocial behaviors in Grade 8. We also considered differences between local and migrant students. The results showed that friend prestige predicted more prosocial behaviors and less antisocial behaviors, whereas friend deviancy predicted less prosocial behaviors and more antisocial behaviors. Moreover, the facilitating effect of friend deviancy on antisocial behaviors was amplified in migrant students more than for local students. Slow life-history strategy predicted more prosocial behaviors and, especially for migrant students, less antisocial behaviors. These findings indicate adolescents’ migrant backgrounds deserve extra attention when investigating peer influence and life-history strategy as distinct contributors to adolescents’ social conduct.

Published
2020
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5. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

Author

Cristina Llorente, Peter Jepsen, Tatsuo Inamine, Lirui Wang, Sena Bluemel, Hui J. Wang, Rohit Loomba, Jasmohan S. Bajaj, Mitchell L. Schubert, Masoumeh Sikaroodi, Patrick M. Gillevet, Jun Xu, Tatiana Kisseleva, Samuel B. Ho, Jessica DePew, Xin Du, Henrik T. Sørensen, Hendrik Vilstrup, Karen E. Nelson, David A. Brenner, Derrick E. Fouts, and Bernd Schnabl

Subjects
Science
Abstract

Proton pump inhibitors (PPIs) reduce gastric acid secretion and modulate gut microbiota composition. Here Llorente et al. show that PPIs induce bacterial overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disease both in mice and humans.

Published
2017
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6. Corrosion Resistance of DLC Film-Coated SUS316L Steel Prepared by Ion Beam Enhanced Deposition

Author

Bei B. Han, Dong Y. Ju, Mao R. Chai, Hui J. Zhao, and Susumu Sato

Subjects
Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

In order to improve the conductivity and anticorrosive resistance of bipolar plates in fuel cells, the characterizations and corrosion behaviors of the DLC-coated SUS316L steel deposited with different gas ratios CH4/H2 and deposition times were investigated and evaluated. The chemical bonding structure and composition of the DLC coatings were confirmed by Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). The micromorphology and surface roughness of the DLC were observed by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The element compositions of cross section were determined by electron probe microanalysis (EPMA). The interfacial contact resistance (ICR) was measured. Furthermore, the DLC-coated SUS316L steel was corroded by potentiostatic polarizations in a 0.5 M H2SO4 solution at 0.8 V, 90°C for 168 h, and the corrosion behaviors were investigated in the solution using electrochemical techniques. In addition, the metal ions in sulfuric acid corrosion solution were detected by inductively coupled plasma-atomic emission spectroscopy. The results indicate that the DLC coatings deposited at a lower gas ratio CH4/H2 of 1 : 1 could result in a decreasing ID/IG ratio of 1.03, low Ra roughness of 3.77 nm, low ICR of 12.9 mΩ cm2, and low metal ion concentration of 16.60 ppm in the corrosion solution. The significant improvement in the anticorrosion resistance of the DLC film was mainly due to the increased sp3 element and formation of the passive film. As a result, the DLC coating deposited on the SUS316L steel at CH4/H2 = 1 : 1 has better anticorrosion properties. However, the DLC film-coated SUS316L steel still cannot meet the corrosive resistance of the bipolar plate.

Published
2019
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7. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

Author

Cristina Llorente, Peter Jepsen, Tatsuo Inamine, Lirui Wang, Sena Bluemel, Hui J. Wang, Rohit Loomba, Jasmohan S. Bajaj, Mitchell L. Schubert, Masoumeh Sikaroodi, Patrick M. Gillevet, Jun Xu, Tatiana Kisseleva, Samuel B. Ho, Jessica DePew, Xin Du, Henrik T. Sørensen, Hendrik Vilstrup, Karen E. Nelson, David A. Brenner, Derrick E. Fouts, and Bernd Schnabl

Subjects
Science
Abstract

In the original PDF version of this Article, which was published on 16 October 2017, the publication date was incorrectly given as 10 October 2017. This has now been corrected in the PDF; the HTML version of the paper was correct from the time of publication.

Published
2017
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11. Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine

Author

Khanra, Sourav, Reddy, Preethi, Giménez-Palomo, Anna, Park, Chun Hui J., Panizzutti, Bruna, McCallum, Madeleine, Arumugham, Shyam Sundar, Umesh, Shreekantiah, Debnath, Monojit, Das, Basudeb, Venkatasubramanian, Ganesan, Ashton, Melanie, Turner, Alyna, Dean, Olivia M., Walder, Ken, Vieta, Eduard, Yatham, Lakshmi N., Pacchiarotti, Isabella, Reddy, Y. C. Janardhan, Goyal, Nishant, Kesavan, Muralidharan, Colomer, Lluc, Berk, Michael, and Kim, Jee Hyun

Published
2023
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12. Optimization of the JUNO liquid scintillator composition using a Daya Bay antineutrino detector

Author

Bay, Daya, collaborations, JUNO, Abusleme, A., Adam, T., Ahmad, S., Aiello, S., Akram, M., Ali, N., An, F. P., An, G. P., An, Q., Andronico, G., Anfimov, N., Antonelli, V., Antoshkina, T., Asavapibhop, B., de André, J. P. A. M., Babic, A., Balantekin, A. B., Baldini, W., Baldoncini, M., Band, H. R., Barresi, A., Baussan, E., Bellato, M., Bernieri, E., Biare, D., Birkenfeld, T., Bishai, M., Blin, S., Blum, D., Blyth, S., Bordereau, C., Brigatti, A., Brugnera, R., Budano, A., Burgbacher, P., Buscemi, M., Bussino, S., Busto, J., Butorov, I., Cabrera, A., Cai, H., Cai, X., Cai, Y. K., Cai, Z. Y., Cammi, A., Campeny, A., Cao, C. Y., Cao, G. F., Cao, J., Caruso, R., Cerna, C., Chakaberia, I., Chang, J. F., Chang, Y., Chen, H. S., Chen, P. A., Chen, P. P., Chen, S. M., Chen, S. J., Chen, X. R., Chen, Y. W., Chen, Y. X., Chen, Y., Chen, Z., Cheng, J., Cheng, Y. P., Cheng, Z. K., Chepurnov, A., Cherwinka, J. J., Chiarello, F., Chiesa, D., Chimenti, P., Chu, M. C., Chukanov, A., Chuvashova, A., Clementi, ., Clerbaux, B., Di Lorenzo, S. Conforti, Corti, D., Costa, S., Corso, F. D., Cummings, J. P., Dalager, O., De La Taille, C., Deng, F. S., Deng, J. W., Deng, Z., Deng, Z. Y., Depnering, W., Diaz, M., Ding, X. F., Ding, Y. Y., Dirgantara, B., Dmitrievsky, S., Diwan, M. V., Dohnal, T., Donchenko, G., Dong, J. M., Dornic, D., Doroshkevich, E., Dove, J., Dracos, M., Druillole, F., Du, S. X., Dusini, S., Dvorak, M., Dwyer, D. A., Enqvist, T., Enzmann, H., Fabbri, A., Fajt, L., Fan, D. H., Fan, L., Fang, C., Fang, J., Fatkina, A., Fedoseev, D., Fekete, V., Feng, L. C., Feng, Q. C., Fiorentini, G., Ford, R., Formozov, A., Fournier, A., Franke, S., Gallo, J. P., Gan, H. N., Gao, F., Garfagnini, A., Göttel, A., Genster, C., Giammarchi, M., Giaz, A., Giudice, N., Giuliani, F., Gonchar, M., Gong, G. H., Gong, H., Gorchakov, O., Gornushkin, Y., Grassi, M., Grewing, C., Gromov, M., Gromov, V., Gu, M. H., Gu, W. Q., Gu, X. F., Gu, Y., Guan, M. Y., Guardone, N., Gul, M., Guo, C., Guo, J. Y., Guo, L., Guo, W. L., Guo, X. H., Guo, Y. H., Guo, Z., Haacke, M., Hackenburg, R. W., Hackspacher, P., Hagner, C., Han, R., Han, Y., Hans, S., He, M., He, W., Heeger, K. M., Heinz, T., Heng, Y. K., Herrera, R., Higuera, A., Hong, D. J., Hor, Y. K., Hou, S. J., Hsiung, Y. B., Hu, B. Z., Hu, H., Hu, J. R., Hu, J., Hu, S. Y., Hu, T., Hu, Z. J., Huang, C. H., Huang, G. H., Huang, H. X., Huang, Q. H., Huang, W. H., Huang, X. T., Huang, Y. B., Huber, P., Hui, J. Q., Huo, L., Huo, W. J., Huss, C., Hussain, S., Insolia, A., Ioannisian, A., Ioannisyan, D., Isocrate, R., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Ji, X. Z., Jia, H. H., Jia, J. J., Jian, S. Y., Jiang, D., Jiang, X. S., Jin, R. Y., Jing, X. P., Johnson, R. A., Jollet, C., Jones, D., Joutsenvaara, J., Jungthawan, S., Kalousis, L., Kampmann, P., Kang, L., Karagounis, M., Kazarian, N., Kettell, S. H., Khan, A., Khan, W., Khosonthongkee, K., Kinz, P., Kohn, S., Korablev, D., Kouzakov, K., Kramer, M., Krasnoperov, A., Krokhaleva, S., Krumshteyn, Z., Kruth, A., Kutovskiy, N., Kuusiniemi, P., Lachacinski, B., Lachenmaier, T., Langford, T. J., Lee, J., Lee, J. H. C., Lefevre, F., Lei, L., Lei, R., Leitner, R., Leung, J., Li, C., Li, D. M., Li, F., Li, H. T., Li, H. L., Li, J., Li, J. J., Li, J. Q., Li, K. J., Li, M. Z., Li, N., Li, Q. J., Li, R. H., Li, S. C., Li, S. F., Li, S. J., Li, T., Li, W. D., Li, W. G., Li, X. M., Li, X. N., Li, X. L., Li, X. Q., Li, Y., Li, Y. F., Li, Z. B., Li, Z. Y., Liang, H., Liang, J. J., Liebau, D., Limphirat, A., Limpijumnong, S., Lin, C. J., Lin, G. L., Lin, S. X., Lin, T., Lin, Y. H., Ling, J. J., Link, J. M., Lippi, I., Littenberg, L., Littlejohn, B. R., Liu, F., Liu, H., Liu, H. B., Liu, H. D., Liu, H. J., Liu, H. T., Liu, J. C., Liu, J. L., Liu, M., Liu, Q., Liu, R. X., Liu, S. Y., Liu, S. B., Liu, S. L., Liu, X. W., Liu, Y., Lokhov, A., Lombardi, P., Loo, K., Lorenz, S., Lu, C., Lu, H. Q., Lu, J. B., Lu, J. G., Lu, S. X., Lu, X. X., Lubsandorzhiev, B., Lubsandorzhiev, S., Ludhova, L., Luk, K. B., Luo, F. J., Luo, G., Luo, P. W., Luo, S., Luo, W. M., Lyashuk, V., Ma, Q. M., Ma, S., Ma, X. B., Ma, X. Y., Ma, Y. Q., Malyshkin, Y., Mantovani, F., Mao, Y. J., Mari, S. M., Marini, F., Marium, S., Marshall, C., Martellini, C., Martin-Chassard, G., Caicedo, D. A. Martinez, Martini, A., Martino, J., Mayilyan, D., McDonald, K. T., McKeown, R. D., Müller, A., Meng, G., Meng, Y., Meregaglia, A., Meroni, E., Meyhöfer, D., Mezzetto, M., Miller, J., Miramonti, L., Monforte, S., Montini, P., Montuschi, M., Morozov, N., Muralidharan, P., Napolitano, J., Nastasi, M., Naumov, D. V., Naumova, E., Nemchenok, I., Nikolaev, A., Ning, F. P., Ning, Z., Nunokawa, H., Oberauer, L., Ochoa-Ricoux, J. P., Olshevskiy, A., Ortica, F., Pan, H. R., Paoloni, A., Park, J., Parkalian, N., Parmeggiano, S., Patton, S., Payupol, T., Pec, V., Pedretti, D., Pei, Y. T., Pelliccia, N., Peng, A. G., Peng, H. P., Peng, J. C., Perrot, F., Petitjean, P. A., Rico, L. F. Pineres, Popov, A., Poussot, P., Pratumwan, W., Previtali, E., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, S., Qian, X., Qian, X. H., Qiao, H., Qin, Z. H., Qiu, S. K., Rajput, M., Ranucci, G., Raper, N., Re, A., Rebber, H., Rebii, A., Ren, B., Ren, J., Reveco, C. M., Rezinko, T., Ricci, B., Robens, M., Roche, M., Rodphai, N., Rohwer, L., Romani, A., Rosero, R., Roskovec, B., Roth, C., Ruan, X. C., Ruan, X. D., Rujirawat, S., Rybnikov, A., Sadovsky, A., Saggese, P., Salamanna, G., Sangka, A., Sanguansak, N., Sawangwit, U., Sawatzki, J., Sawy, F., Schever, M., Schuler, J., Schwab, C., Schweizer, K., Selivanov, D., Selyunin, A., Serafini, A., Settanta, G., Settimo, M., Shahzad, M., Shi, G., Shi, J. Y., Shi, Y. J., Shutov, V., Sidorenkov, A., Simkovic, F., Sirignano, C., Siripak, J., Sisti, M., Slupecki, M., Smirnov, M., Smirnov, O., Sogo-Bezerra, T., Songwadhana, J., Soonthornthum, B., Sotnikov, A., Sramek, O., Sreethawong, W., Stahl, A., Stanco, L., Stankevich, K., Stefanik, D., Steiger, H., Steiner, H., Steinmann, J., Stender, M., Strati, V., Studenikin, A., Sun, G. X., Sun, L. T., Sun, J. L., Sun, S. F., Sun, X. L., Sun, Y. J., Sun, Y. Z., Suwonjandee, N., Szelezniak, M., Tang, J., Tang, Q., Tang, X., Tietzsch, A., Tkachev, I., Tmej, T., Treskov, K., Troni, G., Trzaska, W., Tse, W. -H., Tull, C. E., Tuve, C., van Waasen, S., Boom, J. Vanden, Vassilopoulos, N., Vedin, V., Verde, G., Vialkov, M., Viaud, B., Viren, B., Volpe, C., Vorobel, V., Votano, L., Walker, P., Wang, C., Wang, C. H., Wang, E., Wang, G. L., Wang, J., Wang, K. Y., Wang, L., Wang, M. F., Wang, M., Wang, N. Y., Wang, R. G., Wang, S. G., Wang, W., Wang, W. S., Wang, X., Wang, X. Y., Wang, Y., Wang, Y. F., Wang, Y. G., Wang, Y. M., Wang, Y. Q., Wang, Z., Wang, Z. M., Wang, Z. Y., Watcharangkool, A., Wei, H. Y., Wei, L. H., Wei, W., Wei, Y. D., Wen, L. J., Whisnant, K., White, C. G., Wiebusch, C., Wong, S. C. F., Wong, H. L. H., Wonsak, B., Worcester, E., Wu, C. H., Wu, D. R., Wu, F. L., Wu, Q., Wu, W. J., Wu, Z., Wurm, M., Wurtz, J., Wysotzki, C., Xi, Y. F., Xia, D. M., Xie, Y. G., Xie, Z. Q., Xing, Z. Z., Xu, D. L., Xu, F. R., Xu, H. K., Xu, J. L., Xu, J., Xu, M. H., Xu, T., Xu, Y., Xue, T., Yan, B. J., Yan, X. B., Yan, Y. P., Yang, A. B., Yang, C. G., Yang, H., Yang, J., Yang, L., Yang, X. Y., Yang, Y. F., Yang, Y. Z., Yao, H. F., Yasin, Z., Ye, J. X., Ye, M., Yegin, U., Yeh, M., Yermia, F., Yi, P. H., You, Z. Y., Young, B. L., Yu, B. X., Yu, C. X., Yu, C. Y., Yu, H. Z., Yu, M., Yu, X. H., Yu, Z. Y., Yuan, C. Z., Yuan, Y., Yuan, Z. X., Yuan, Z. Y., Yue, B. B., Zafar, N., Zambanini, A., Zeng, P., Zeng, S., Zeng, T. X., Zeng, Y. D., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, G. Q., Zhang, H. H., Zhang, H. Q., Zhang, J., Zhang, J. B., Zhang, J. W., Zhang, P., Zhang, Q. M., Zhang, T., Zhang, X. M., Zhang, X. T., Zhang, Y., Zhang, Y. H., Zhang, Y. M., Zhang, Y. P., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, F. Y., Zhao, J., Zhao, R., Zhao, S. J., Zhao, T. C., Zheng, D. Q., Zheng, H., Zheng, M. S., Zheng, Y. H., Zhong, W. R., Zhou, J., Zhou, L., Zhou, N., Zhou, S., Zhou, X., Zhu, J., Zhu, K. J., Zhuang, H. L., Zong, L., and Zou, J. H.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

To maximize the light yield of the liquid scintillator (LS) for the Jiangmen Underground Neutrino Observatory (JUNO), a 20 t LS sample was produced in a pilot plant at Daya Bay. The optical properties of the new LS in various compositions were studied by replacing the gadolinium-loaded LS in one antineutrino detector. The concentrations of the fluor, PPO, and the wavelength shifter, bis-MSB, were increased in 12 steps from 0.5 g/L and <0.01 mg/L to 4 g/L and 13 mg/L, respectively. The numbers of total detected photoelectrons suggest that, with the optically purified solvent, the bis-MSB concentration does not need to be more than 4 mg/L. To bridge the one order of magnitude in the detector size difference between Daya Bay and JUNO, the Daya Bay data were used to tune the parameters of a newly developed optical model. Then, the model and tuned parameters were used in the JUNO simulation. This enabled to determine the optimal composition for the JUNO LS: purified solvent LAB with 2.5 g/L PPO, and 1 to 4 mg/L bis-MSB., Comment: 13 pages, 8 figures

Published
2020

15. Contralateral Hemispheric Cerebral Blood Flow Measured With Arterial Spin Labeling Can Predict Outcome in Acute Stroke

Author

Thamm, Thoralf, Guo, Jia, Rosenberg, Jarrett, Liang, Tie, Marks, Michael P, Christensen, Soren, Do, Huy M, Kemp, Stephanie M, Adair, Emma, Eyngorn, Irina, Mlynash, Michael, Jovin, Tudor G, Keogh, Bart P, Chen, Hui J, Lansberg, Maarten G, Albers, Gregory W, and Zaharchuk, Greg

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Neurosciences, Brain Disorders, Stroke, Biomedical Imaging, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Aged, Brain, Brain Ischemia, Cerebrovascular Circulation, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Prospective Studies, Treatment Outcome, cerebrovascular circulation, magnetic resonance imaging, perfusion imaging, prognosis, prospective studies, stroke, Cardiorespiratory Medicine and Haematology, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and Purpose- Imaging is frequently used to select acute stroke patients for intra-arterial therapy. Quantitative cerebral blood flow can be measured noninvasively with arterial spin labeling magnetic resonance imaging. Cerebral blood flow levels in the contralateral (unaffected) hemisphere may affect capacity for collateral flow and patient outcome. The goal of this study was to determine whether higher contralateral cerebral blood flow (cCBF) in acute stroke identifies patients with better 90-day functional outcome. Methods- Patients were part of the prospective, multicenter iCAS study (Imaging Collaterals in Acute Stroke) between 2013 and 2017. Consecutive patients were enrolled after being diagnosed with anterior circulation acute ischemic stroke. Inclusion criteria were ischemic anterior circulation stroke, baseline National Institutes of Health Stroke Scale score ≥1, prestroke modified Rankin Scale score ≤2, onset-to-imaging time

Published
2019

17. BCL6 coordinates muscle mass homeostasis with nutritional states.

Author

Wang, Hui J., Weiwei Fan, Sihao Liu, Kyeongkyu Kim, Ayami Matsushima, Satoshi Ogawa, Hyun Gyu Kang, Jonathan Zhu, Estepa, Gabriela, Mingxiao He, Crossley, Lillian, Liddle, Christopher, Kim, Minseok S., Truitt, Morgan L., Yu, Ruth T., Atkins, Annette R., Downes, Michael, and Evans, Ronald M.

Subjects
*SUPPRESSORS of cytokine signaling, *B cell lymphoma, *MUSCLE mass, *MUSCLE strength, *SOMATOTROPIN
Abstract

Nutritional status is a determining factor for growth during development and homeostatic maintenance in adulthood. In the context of muscle, growth hormone (GH) coordinates growth with nutritional status; however, the detailed mechanisms remain to be fully elucidated. Here, we show that the transcriptional repressor B cell lymphoma 6 (BCL6) maintains muscle mass by sustaining GH action. Muscle-specific genetic deletion of BCL6 at either perinatal or adult stages profoundly reduces muscle mass and compromises muscle strength. Conversely, muscle-directed viral overexpression of BCL6 significantly reverses the loss of muscle mass and strength. Mechanistically, we show that BCL6 transcriptionally represses the suppressor of cytokine signaling 2 to sustain the anabolic actions of GH in muscle. Additionally, we find that GH itself transcriptionally inhibits BCL6 through the Janus kinase and signal transducer and activator of transcription 5 (JAK/STAT5) pathway. Supporting the physiologic relevance of this feedback regulation, we show the coordinated suppression of muscle Bcl6 expression with the induction of GH in the fasted state. These findings reveal the complexity of the feedback controls modulating GH signaling and identify BCL6 as a key homeostatic regulator coordinating muscle mass with nutrient availability. Moreover, these studies open avenues for targeted therapeutic strategies to combat muscle-wasting conditions. [ABSTRACT FROM AUTHOR]

Published
2025
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21. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus.

Author

Llorente, Cristina, Jepsen, Peter, Inamine, Tatsuo, Wang, Lirui, Bluemel, Sena, Wang, Hui J, Loomba, Rohit, Bajaj, Jasmohan S, Schubert, Mitchell L, Sikaroodi, Masoumeh, Gillevet, Patrick M, Xu, Jun, Kisseleva, Tatiana, Ho, Samuel B, DePew, Jessica, Du, Xin, Sørensen, Henrik T, Vilstrup, Hendrik, Nelson, Karen E, Brenner, David A, Fouts, Derrick E, and Schnabl, Bernd

Abstract

In the original PDF version of this Article, which was published on 16 October 2017, the publication date was incorrectly given as 10 October 2017. This has now been corrected in the PDF; the HTML version of the paper was correct from the time of publication.

Published
2017

26. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

Author

Llorente, Cristina, Jepsen, Peter, Inamine, Tatsuo, Wang, Lirui, Bluemel, Sena, Wang, Hui J, Loomba, Rohit, Bajaj, Jasmohan S, Schubert, Mitchell L, Sikaroodi, Masoumeh, Gillevet, Patrick M, Xu, Jun, Kisseleva, Tatiana, Ho, Samuel B, DePew, Jessica, Du, Xin, Sørensen, Henrik T, Vilstrup, Hendrik, Nelson, Karen E, Brenner, David A, Fouts, Derrick E, and Schnabl, Bernd

Subjects
Alcoholism, Alcohol Use and Health, Genetics, Hepatitis, Chronic Liver Disease and Cirrhosis, Liver Disease, Substance Misuse, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Oral and gastrointestinal, Good Health and Well Being, Animals, Disease Progression, Enterococcus, Female, Gastric Acid, Humans, Incidence, Liver Diseases, Alcoholic, Male, Mice, Mice, Inbred C57BL, Microbiota, Non-alcoholic Fatty Liver Disease, Proton Pump Inhibitors
Abstract

Chronic liver disease is rising in western countries and liver cirrhosis is the 12th leading cause of death worldwide. Simultaneously, use of gastric acid suppressive medications is increasing. Here, we show that proton pump inhibitors promote progression of alcoholic liver disease, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis in mice by increasing numbers of intestinal Enterococcus spp. Translocating enterococci lead to hepatic inflammation and hepatocyte death. Expansion of intestinal Enterococcus faecalis is sufficient to exacerbate ethanol-induced liver disease in mice. Proton pump inhibitor use increases the risk of developing alcoholic liver disease among alcohol-dependent patients. Reduction of gastric acid secretion therefore appears to promote overgrowth of intestinal Enterococcus, which promotes liver disease, based on data from mouse models and humans. Recent increases in the use of gastric acid-suppressive medications might contribute to the increasing incidence of chronic liver disease.

Published
2016

27. Lipidomic Risk Score to Enhance Cardiovascular Risk Stratification for Primary Prevention

Author

Wu, J, Giles, C, Dakic, A, Beyene, HB, Huynh, K, Wang, T, Meikle, T, Olshansky, G, Salim, A, Duong, T, Watts, GF, Hung, J, Hui, J, Cadby, G, Beilby, J, Blangero, J, Moses, EK, Shaw, JE, Magliano, DJ, Zhu, D, Yang, JY, Grieve, SM, Wilson, A, Chow, CK, Vernon, ST, Gray, MP, Figtree, GA, Carrington, MJ, Inouye, M, Marwick, TH, Meikle, PJ, Wu, J, Giles, C, Dakic, A, Beyene, HB, Huynh, K, Wang, T, Meikle, T, Olshansky, G, Salim, A, Duong, T, Watts, GF, Hung, J, Hui, J, Cadby, G, Beilby, J, Blangero, J, Moses, EK, Shaw, JE, Magliano, DJ, Zhu, D, Yang, JY, Grieve, SM, Wilson, A, Chow, CK, Vernon, ST, Gray, MP, Figtree, GA, Carrington, MJ, Inouye, M, Marwick, TH, and Meikle, PJ

Abstract

BACKGROUND: Accurate risk stratification is vital for primary prevention of cardiovascular disease (CVD). However, traditional tools such as the Framingham Risk Score (FRS) may underperform within the diverse intermediate-risk group, which includes individuals requiring distinct management strategies. OBJECTIVES: This study aimed to develop a lipidomic-enhanced risk score (LRS), specifically targeting risk prediction and reclassification within the intermediate group, benchmarked against the FRS. METHODS: The LRS was developed via a machine learning workflow using ridge regression on the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab; n = 10,339). It was externally validated with the Busselton Health Study (n = 4,492), and its predictive utility for coronary artery calcium scoring (CACS)-based outcomes was independently validated in the BioHEART cohort (n = 994). RESULTS: LRS significantly improved discrimination metrics for the intermediate-risk group in both AusDiab and Busselton Health Study cohorts (all P < 0.001), increasing the area under the curve for CVD events by 0.114 (95% CI: 0.1123-0.1157) and 0.077 (95% CI: 0.0755-0.0785), with a net reclassification improvement of 0.36 (95% CI: 0.21-0.51) and 0.33 (95% CI: 0.15-0.49), respectively. For CACS-based outcomes in BioHEART, LRS achieved a significant area under the curve improvement of 0.02 over the FRS (0.76 vs 0.74; P < 1.0 × 10-5). A simplified, clinically applicable version of LRS was also created that had comparable performance to the original LRS. CONCLUSIONS: LRS, augmenting the FRS, presents potential to improve intermediate-risk stratification and to predict atherosclerotic markers using a simple blood test, suitable for clinical application. This could facilitate the triage of individuals for noninvasive imaging such as CACS, fostering precision medicine in CVD prevention and management.

Published
2024

28. Real-time monitoring for the next core-collapse supernova in JUNO

Author

Abusleme, A, Adam, T, Ahmad, S, Ahmed, R, Aiello, S, Akram, M, Aleem, A, An, F, An, Q, Andronico, G, Anfimov, N, Antonelli, V, Antoshkina, T, Asavapibhop, B, de André, J, Auguste, D, Bai, W, Balashov, N, Baldini, W, Barresi, A, Basilico, D, Baussan, E, Bellato, M, Beretta, M, Bergnoli, A, Bick, D, Bieger, L, Biktemerova, S, Birkenfeld, T, Morton-Blake, I, Blum, D, Blyth, S, Bolshakova, A, Bongrand, M, Bordereau, C, Breton, D, Brigatti, A, Brugnera, R, Bruno, R, Budano, A, Busto, J, Cabrera, A, Caccianiga, B, Cai, H, Cai, X, Cai, Y, Cai, Z, Callier, S, Cammi, A, Campeny, A, Cao, C, Cao, G, Cao, J, Caruso, R, Cerna, C, Cerrone, V, Chan, C, Chang, J, Chang, Y, Chatrabhuti, A, Chen, C, Chen, G, Chen, P, Chen, S, Chen, Y, Chen, Z, Cheng, J, Cheng, Y, Chepurnov, A, Chetverikov, A, Chiesa, D, Chimenti, P, Chin, Y, Chu, Z, Chukanov, A, Claverie, G, Clementi, C, Clerbaux, B, Molla, M, Lorenzo, S, Coppi, A, Corti, D, Csakli, S, Corso, F, Dalager, O, Datta, J, Taille, C, Deng, Z, Ding, X, Ding, Y, Dirgantara, B, Dittrich, C, Dmitrievsky, S, Dohnal, T, Dolzhikov, D, Donchenko, G, Dong, J, Doroshkevich, E, Dou, W, Dracos, M, Druillole, F, Du, R, Du, S, Dugas, K, Dusini, S, Duyang, H, Eck, J, Enqvist, T, Fabbri, A, Fahrendholz, U, Fan, L, Fang, J, Fang, W, Fargetta, M, Fedoseev, D, Fei, Z, Feng, L, Feng, Q, Ferraro, F, Fournier, A, Gan, H, Gao, F, Garfagnini, A, Gavrikov, A, Giammarchi, M, Giudice, N, Gonchar, M, Gong, G, Gong, H, Gornushkin, Y, Göttel, A, Grassi, M, Gromov, M, Gromov, V, Gu, M, Gu, X, Gu, Y, Guan, M, Guan, Y, Guardone, N, Guo, C, Guo, W, Guo, X, Hagner, C, Han, R, Han, Y, He, M, He, W, Heinz, T, Hellmuth, P, Heng, Y, Herrera, R, Hor, Y, Hou, S, Hsiung, Y, Hu, B, Hu, H, Hu, J, Hu, S, Hu, T, Hu, Y, Hu, Z, Huang, G, Huang, H, Huang, J, Huang, K, Huang, W, Huang, X, Huang, Y, Hui, J, Huo, L, Huo, W, Huss, C, Hussain, S, Imbert, L, Ioannisian, A, Isocrate, R, Jafar, A, Jelmini, B, Jeria, I, Ji, X, Jia, H, Jia, J, Jian, S, Jiang, C, Jiang, D, Jiang, W, Jiang, X, Jing, X, Jollet, C, Kampmann, P, Kang, L, Karaparambil, R, Kazarian, N, Khan, A, Khatun, A, Khosonthongkee, K, Korablev, D, Kouzakov, K, Krasnoperov, A, Kuleshov, S, Kutovskiy, N, Labit, L, Lachenmaier, T, Landini, C, Leblanc, S, Lebrin, V, Lefevre, F, Lei, R, Leitner, R, Leung, J, Li, D, Li, F, Li, G, Li, H, Li, J, Li, M, Li, N, Li, Q, Li, R, Li, S, Li, T, Li, W, Li, X, Li, Y, Li, Z, Liang, H, Liao, J, Limphirat, A, Lin, G, Lin, S, Lin, T, Ling, J, Ling, X, Lippi, I, Liu, C, Liu, F, Liu, H, Liu, J, Liu, M, Liu, Q, Liu, R, Liu, S, Liu, X, Liu, Y, Liu, Z, Lokhov, A, Lombardi, P, Lombardo, C, Loo, K, Lu, C, Lu, H, Lu, J, Lu, P, Lu, S, Lu, X, Lubsandorzhiev, B, Lubsandorzhiev, S, Ludhova, L, Lukanov, A, Luo, D, Luo, F, Luo, G, Luo, J, Luo, S, Luo, W, Luo, X, Lyashuk, V, Ma, B, Ma, Q, Ma, S, Ma, X, Maalmi, J, Magoni, M, Mai, J, Malyshkin, Y, Mandujano, R, Mantovani, F, Mao, X, Mao, Y, Mari, S, Marini, F, Martini, A, Mayer, M, Mayilyan, D, Mednieks, I, Meng, Y, Meraviglia, A, Meregaglia, A, Meroni, E, Meyhöfer, D, Miramonti, L, Mohan, N, Montuschi, M, Müller, A, Nastasi, M, Naumov, D, Naumova, E, Navas-Nicolas, D, Nemchenok, I, Thi, M, Nikolaev, A, Ning, F, Ning, Z, Nunokawa, H, Oberauer, L, Ochoa-Ricoux, J, Olshevskiy, A, Orestano, D, Ortica, F, Othegraven, R, Paoloni, A, Parmeggiano, S, Pei, Y, Pelicci, L, Peng, A, Peng, H, Peng, Y, Peng, Z, Perrot, F, Petitjean, P, Petrucci, F, Pilarczyk, O, Rico, L, Popov, A, Poussot, P, Previtali, E, Qi, F, Qi, M, Qi, X, Qian, S, Qian, X, Qian, Z, Qiao, H, Qin, Z, Qiu, S, Qu, M, Qu, Z, Ranucci, G, Rasheed, R, Re, A, Rebii, A, Redchuk, M, Ren, B, Ren, J, Ricci, B, Rientong, K, Rifai, M, Roche, M, Rodphai, N, Romani, A, Roskovec, B, Ruan, X, Rybnikov, A, Sadovsky, A, Saggese, P, Sandanayake, D, Sangka, A, Sava, G, Sawangwit, U, Schever, M, Schwab, C, Schweizer, K, Selyunin, A, Serafini, A, Settimo, M, Sharov, V, Shaydurova, A, Shi, J, Shi, Y, Shutov, V, Sidorenkov, A, Šimkovic, F, Singhal, A, Sirignano, C, Siripak, J, Sisti, M, Smirnov, M, Smirnov, O, Sogo-Bezerra, T, Sokolov, S, Songwadhana, J, Soonthornthum, B, Sotnikov, A, Šrámek, O, Sreethawong, W, Stahl, A, Stanco, L, Stankevich, K, Steiger, H, Steinmann, J, Sterr, T, Stock, M, Strati, V, Studenikin, A, Su, A, Su, J, Sun, S, Sun, X, Sun, Y, Sun, Z, Suwonjandee, N, Szelezniak, M, Takenaka, A, Tang, J, Tang, Q, Tang, X, Hariharan, V, Theisen, E, Tietzsch, A, Tkachev, I, Tmej, T, Torri, M, Tortorici, F, Treskov, K, Triossi, A, Triozzi, R, Trzaska, W, Tung, Y, Tuve, C, Ushakov, N, Vedin, V, Venettacci, C, Verde, G, Vialkov, M, Viaud, B, Vollbrecht, C, von Sturm, K, Vorobel, V, Voronin, D, Votano, L, Walker, P, Wang, C, Wang, E, Wang, G, Wang, J, Wang, L, Wang, M, Wang, R, Wang, S, Wang, W, Wang, X, Wang, Y, Wang, Z, Watcharangkool, A, Wei, W, Wei, Y, Wen, K, Wen, L, Weng, J, Wiebusch, C, Wirth, R, Wonsak, B, Wu, D, Wu, Q, Wu, Y, Wu, Z, Wurm, M, Wurtz, J, Wysotzki, C, Xi, Y, Xia, D, Xiao, F, Xiao, X, Xie, X, Xie, Y, Xie, Z, Xin, Z, Xing, Z, Xu, B, Xu, C, Xu, D, Xu, F, Xu, H, Xu, J, Xu, M, Xu, X, Xu, Y, Yan, B, Yan, Q, Yan, T, Yan, X, Yan, Y, Yang, C, Yang, J, Yang, L, Yang, X, Yang, Y, Yao, H, Ye, J, Ye, M, Ye, Z, Yermia, F, You, Z, Yu, B, Yu, C, Yu, G, Yu, H, Yu, M, Yu, X, Yu, Z, Yuan, C, Yuan, Y, Yuan, Z, Yue, B, Zafar, N, Zavadskyi, V, Zeng, F, Zeng, S, Zeng, T, Zeng, Y, Zhan, L, Zhang, A, Zhang, B, Zhang, F, Zhang, H, Zhang, J, Zhang, L, Zhang, M, Zhang, P, Zhang, Q, Zhang, S, Zhang, T, Zhang, X, Zhang, Y, Zhang, Z, Zhao, J, Zhao, R, Zhao, S, Zheng, D, Zheng, H, Zheng, Y, Zhong, W, Zhou, J, Zhou, L, Zhou, N, Zhou, S, Zhou, T, Zhou, X, Zhu, J, Zhu, K, Zhu, Z, Zhuang, B, Zhuang, H, Zong, L, Zou, J, Züfle, J, Null, N, Abusleme, Angel, Adam, Thomas, Ahmad, Shakeel, Ahmed, Rizwan, Aiello, Sebastiano, Akram, Muhammad, Aleem, Abid, An, Fengpeng, An, Qi, Andronico, Giuseppe, Anfimov, Nikolay, Antonelli, Vito, Antoshkina, Tatiana, Asavapibhop, Burin, de André, João Pedro Athayde Marcondes, Auguste, Didier, Bai, Weidong, Balashov, Nikita, Baldini, Wander, Barresi, Andrea, Basilico, Davide, Baussan, Eric, Bellato, Marco, Beretta, Marco, Bergnoli, Antonio, Bick, Daniel, Bieger, Lukas, Biktemerova, Svetlana, Birkenfeld, Thilo, Morton-Blake, Iwan, Blum, David, Blyth, Simon, Bolshakova, Anastasia, Bongrand, Mathieu, Bordereau, Clément, Breton, Dominique, Brigatti, Augusto, Brugnera, Riccardo, Bruno, Riccardo, Budano, Antonio, Busto, Jose, Cabrera, Anatael, Caccianiga, Barbara, Cai, Hao, Cai, Xiao, Cai, Yanke, Cai, Zhiyan, Callier, Stéphane, Cammi, Antonio, Campeny, Agustin, Cao, Chuanya, Cao, Guofu, Cao, Jun, Caruso, Rossella, Cerna, Cédric, Cerrone, Vanessa, Chan, Chi, Chang, Jinfan, Chang, Yun, Chatrabhuti, Auttakit, Chen, Chao, Chen, Guoming, Chen, Pingping, Chen, Shaomin, Chen, Yixue, Chen, Yu, Chen, Zhangming, Chen, Zhiyuan, Chen, Zikang, Cheng, Jie, Cheng, Yaping, Cheng, Yu Chin, Chepurnov, Alexander, Chetverikov, Alexey, Chiesa, Davide, Chimenti, Pietro, Chin, Yen-Ting, Chu, Ziliang, Chukanov, Artem, Claverie, Gérard, Clementi, Catia, Clerbaux, Barbara, Molla, Marta Colomer, Lorenzo, Selma Conforti Di, Coppi, Alberto, Corti, Daniele, Csakli, Simon, Corso, Flavio Dal, Dalager, Olivia, Datta, Jaydeep, Taille, Christophe De La, Deng, Zhi, Deng, Ziyan, Ding, Xiaoyu, Ding, Xuefeng, Ding, Yayun, Dirgantara, Bayu, Dittrich, Carsten, Dmitrievsky, Sergey, Dohnal, Tadeas, Dolzhikov, Dmitry, Donchenko, Georgy, Dong, Jianmeng, Doroshkevich, Evgeny, Dou, Wei, Dracos, Marcos, Druillole, Frédéric, Du, Ran, Du, Shuxian, Dugas, Katherine, Dusini, Stefano, Duyang, Hongyue, Eck, Jessica, Enqvist, Timo, Fabbri, Andrea, Fahrendholz, Ulrike, Fan, Lei, Fang, Jian, Fang, Wenxing, Fargetta, Marco, Fedoseev, Dmitry, Fei, Zhengyong, Feng, Li-Cheng, Feng, Qichun, Ferraro, Federico, Fournier, Amélie, Gan, Haonan, Gao, Feng, Garfagnini, Alberto, Gavrikov, Arsenii, Giammarchi, Marco, Giudice, Nunzio, Gonchar, Maxim, Gong, Guanghua, Gong, Hui, Gornushkin, Yuri, Göttel, Alexandre, Grassi, Marco, Gromov, Maxim, Gromov, Vasily, Gu, Minghao, Gu, Xiaofei, Gu, Yu, Guan, Mengyun, Guan, Yuduo, Guardone, Nunzio, Guo, Cong, Guo, Wanlei, Guo, Xinheng, Hagner, Caren, Han, Ran, Han, Yang, He, Miao, He, Wei, Heinz, Tobias, Hellmuth, Patrick, Heng, Yuekun, Herrera, Rafael, Hor, YuenKeung, Hou, Shaojing, Hsiung, Yee, Hu, Bei-Zhen, Hu, Hang, Hu, Jianrun, Hu, Jun, Hu, Shouyang, Hu, Tao, Hu, Yuxiang, Hu, Zhuojun, Huang, Guihong, Huang, Hanxiong, Huang, Jinhao, Huang, Junting, Huang, Kaixuan, Huang, Wenhao, Huang, Xin, Huang, Xingtao, Huang, Yongbo, Hui, Jiaqi, Huo, Lei, Huo, Wenju, Huss, Cédric, Hussain, Safeer, Imbert, Leonard, Ioannisian, Ara, Isocrate, Roberto, Jafar, Arshak, Jelmini, Beatrice, Jeria, Ignacio, Ji, Xiaolu, Jia, Huihui, Jia, Junji, Jian, Siyu, Jiang, Cailian, Jiang, Di, Jiang, Wei, Jiang, Xiaoshan, Jing, Xiaoping, Jollet, Cécile, Kampmann, Philipp, Kang, Li, Karaparambil, Rebin, Kazarian, Narine, Khan, Ali, Khatun, Amina, Khosonthongkee, Khanchai, Korablev, Denis, Kouzakov, Konstantin, Krasnoperov, Alexey, Kuleshov, Sergey, Kutovskiy, Nikolay, Labit, Loïc, Lachenmaier, Tobias, Landini, Cecilia, Leblanc, Sébastien, Lebrin, Victor, Lefevre, Frederic, Lei, Ruiting, Leitner, Rupert, Leung, Jason, Li, Demin, Li, Fei, Li, Fule, Li, Gaosong, Li, Huiling, Li, Jiajun, Li, Mengzhao, Li, Min, Li, Nan, Li, Qingjiang, Li, Ruhui, Li, Rui, Li, Shanfeng, Li, Tao, Li, Teng, Li, Weidong, Li, Weiguo, Li, Xiaomei, Li, Xiaonan, Li, Xinglong, Li, Yi, Li, Yichen, Li, Yufeng, Li, Zhaohan, Li, Zhibing, Li, Ziyuan, Li, Zonghai, Liang, Hao, Liao, Jiajun, Limphirat, Ayut, Lin, Guey-Lin, Lin, Shengxin, Lin, Tao, Ling, Jiajie, Ling, Xin, Lippi, Ivano, Liu, Caimei, Liu, Fang, Liu, Fengcheng, Liu, Haidong, Liu, Haotian, Liu, Hongbang, Liu, Hongjuan, Liu, Hongtao, Liu, Hui, Liu, Jianglai, Liu, Jiaxi, Liu, Jinchang, Liu, Min, Liu, Qian, Liu, Qin, Liu, Runxuan, Liu, Shenghui, Liu, Shubin, Liu, Shulin, Liu, Xiaowei, Liu, Xiwen, Liu, Xuewei, Liu, Yankai, Liu, Zhen, Lokhov, Alexey, Lombardi, Paolo, Lombardo, Claudio, Loo, Kai, Lu, Chuan, Lu, Haoqi, Lu, Jingbin, Lu, Junguang, Lu, Peizhi, Lu, Shuxiang, Lu, Xianguo, Lubsandorzhiev, Bayarto, Lubsandorzhiev, Sultim, Ludhova, Livia, Lukanov, Arslan, Luo, Daibin, Luo, Fengjiao, Luo, Guang, Luo, Jianyi, Luo, Shu, Luo, Wuming, Luo, Xiaojie, Lyashuk, Vladimir, Ma, Bangzheng, Ma, Bing, Ma, Qiumei, Ma, Si, Ma, Xiaoyan, Ma, Xubo, Maalmi, Jihane, Magoni, Marco, Mai, Jingyu, Malyshkin, Yury, Mandujano, Roberto Carlos, Mantovani, Fabio, Mao, Xin, Mao, Yajun, Mari, Stefano M., Marini, Filippo, Martini, Agnese, Mayer, Matthias, Mayilyan, Davit, Mednieks, Ints, Meng, Yue, Meraviglia, Anita, Meregaglia, Anselmo, Meroni, Emanuela, Meyhöfer, David, Miramonti, Lino, Mohan, Nikhil, Montuschi, Michele, Müller, Axel, Nastasi, Massimiliano, Naumov, Dmitry V., Naumova, Elena, Navas-Nicolas, Diana, Nemchenok, Igor, Thi, Minh Thuan Nguyen, Nikolaev, Alexey, Ning, Feipeng, Ning, Zhe, Nunokawa, Hiroshi, Oberauer, Lothar, Ochoa-Ricoux, Juan Pedro, Olshevskiy, Alexander, Orestano, Domizia, Ortica, Fausto, Othegraven, Rainer, Paoloni, Alessandro, Parmeggiano, Sergio, Pei, Yatian, Pelicci, Luca, Peng, Anguo, Peng, Haiping, Peng, Yu, Peng, Zhaoyuan, Perrot, Frédéric, Petitjean, Pierre-Alexandre, Petrucci, Fabrizio, Pilarczyk, Oliver, Rico, Luis Felipe Piñeres, Popov, Artyom, Poussot, Pascal, Previtali, Ezio, Qi, Fazhi, Qi, Ming, Qi, Xiaohui, Qian, Sen, Qian, Xiaohui, Qian, Zhen, Qiao, Hao, Qin, Zhonghua, Qiu, Shoukang, Qu, Manhao, Qu, Zhenning, Ranucci, Gioacchino, Rasheed, Reem, Re, Alessandra, Rebii, Abdel, Redchuk, Mariia, Ren, Bin, Ren, Jie, Ricci, Barbara, Rientong, Komkrit, Rifai, Mariam, Roche, Mathieu, Rodphai, Narongkiat, Romani, Aldo, Roskovec, Bedřich, Ruan, Xichao, Rybnikov, Arseniy, Sadovsky, Andrey, Saggese, Paolo, Sandanayake, Deshan, Sangka, Anut, Sava, Giuseppe, Sawangwit, Utane, Schever, Michaela, Schwab, Cédric, Schweizer, Konstantin, Selyunin, Alexandr, Serafini, Andrea, Settimo, Mariangela, Sharov, Vladislav, Shaydurova, Arina, Shi, Jingyan, Shi, Yanan, Shutov, Vitaly, Sidorenkov, Andrey, Šimkovic, Fedor, Singhal, Apeksha, Sirignano, Chiara, Siripak, Jaruchit, Sisti, Monica, Smirnov, Mikhail, Smirnov, Oleg, Sogo-Bezerra, Thiago, Sokolov, Sergey, Songwadhana, Julanan, Soonthornthum, Boonrucksar, Sotnikov, Albert, Šrámek, Ondřej, Sreethawong, Warintorn, Stahl, Achim, Stanco, Luca, Stankevich, Konstantin, Steiger, Hans, Steinmann, Jochen, Sterr, Tobias, Stock, Matthias Raphael, Strati, Virginia, Studenikin, Alexander, Su, Aoqi, Su, Jun, Sun, Shifeng, Sun, Xilei, Sun, Yongjie, Sun, Yongzhao, Sun, Zhengyang, Suwonjandee, Narumon, Szelezniak, Michal, Takenaka, Akira, Tang, Jian, Tang, Qiang, Tang, Quan, Tang, Xiao, Hariharan, Vidhya Thara, Theisen, Eric, Tietzsch, Alexander, Tkachev, Igor, Tmej, Tomas, Torri, Marco Danilo Claudio, Tortorici, Francesco, Treskov, Konstantin, Triossi, Andrea, Triozzi, Riccardo, Trzaska, Wladyslaw, Tung, Yu-Chen, Tuve, Cristina, Ushakov, Nikita, Vedin, Vadim, Venettacci, Carlo, Verde, Giuseppe, Vialkov, Maxim, Viaud, Benoit, Vollbrecht, Cornelius Moritz, von Sturm, Katharina, Vorobel, Vit, Voronin, Dmitriy, Votano, Lucia, Walker, Pablo, Wang, Caishen, Wang, Chung-Hsiang, Wang, En, Wang, Guoli, Wang, Jian, Wang, Jun, Wang, Li, Wang, Lu, Wang, Meng, Wang, Ruiguang, Wang, Siguang, Wang, Wei, Wang, Wenshuai, Wang, Xi, Wang, Xiangyue, Wang, Yangfu, Wang, Yaoguang, Wang, Yi, Wang, Yifang, Wang, Yuanqing, Wang, Yuyi, Wang, Zhe, Wang, Zheng, Wang, Zhimin, Watcharangkool, Apimook, Wei, Wei, Wei, Wenlu, Wei, Yadong, Wei, Yuehuan, Wen, Kaile, Wen, Liangjian, Weng, Jun, Wiebusch, Christopher, Wirth, Rosmarie, Wonsak, Bjoern, Wu, Diru, Wu, Qun, Wu, Yiyang, Wu, Zhi, Wurm, Michael, Wurtz, Jacques, Wysotzki, Christian, Xi, Yufei, Xia, Dongmei, Xiao, Fei, Xiao, Xiang, Xie, Xiaochuan, Xie, Yuguang, Xie, Zhangquan, Xin, Zhao, Xing, Zhizhong, Xu, Benda, Xu, Cheng, Xu, Donglian, Xu, Fanrong, Xu, Hangkun, Xu, Jilei, Xu, Jing, Xu, Meihang, Xu, Xunjie, Xu, Yin, Xu, Yu, Yan, Baojun, Yan, Qiyu, Yan, Taylor, Yan, Xiongbo, Yan, Yupeng, Yang, Changgen, Yang, Chengfeng, Yang, Jie, Yang, Lei, Yang, Xiaoyu, Yang, Yifan, Yao, Haifeng, Ye, Jiaxuan, Ye, Mei, Ye, Ziping, Yermia, Frédéric, You, Zhengyun, Yu, Boxiang, Yu, Chiye, Yu, Chunxu, Yu, Guojun, Yu, Hongzhao, Yu, Miao, Yu, Xianghui, Yu, Zeyuan, Yu, Zezhong, Yuan, Cenxi, Yuan, Chengzhuo, Yuan, Ying, Yuan, Zhenxiong, Yue, Baobiao, Zafar, Noman, Zavadskyi, Vitalii, Zeng, Fanrui, Zeng, Shan, Zeng, Tingxuan, Zeng, Yuda, Zhan, Liang, Zhang, Aiqiang, Zhang, Bin, Zhang, Binting, Zhang, Feiyang, Zhang, Haosen, Zhang, Honghao, Zhang, Jialiang, Zhang, Jiawen, Zhang, Jie, Zhang, Jingbo, Zhang, Jinnan, ZHANG, Lei, Zhang, Mohan, Zhang, Peng, Zhang, Ping, Zhang, Qingmin, Zhang, Shiqi, Zhang, Shu, Zhang, Shuihan, Zhang, Siyuan, Zhang, Tao, Zhang, Xiaomei, Zhang, Xin, Zhang, Xuantong, Zhang, Yinhong, Zhang, Yiyu, Zhang, Yongpeng, Zhang, Yu, Zhang, Yuanyuan, Zhang, Yumei, Zhang, Zhenyu, Zhang, Zhijian, Zhao, Jie, Zhao, Rong, Zhao, Runze, Zhao, Shujun, 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Abstract

The core-collapse supernova (CCSN) is considered one of the most energetic astrophysical events in the universe. The early and prompt detection of neutrinos before (pre-SN) and during the supernova (SN) burst presents a unique opportunity for multi-messenger observations of CCSN events. In this study, we describe the monitoring concept and present the sensitivity of the system to pre-SN and SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), a 20 kton liquid scintillator detector currently under construction in South China. The real-time monitoring system is designed to ensure both prompt alert speed and comprehensive coverage of progenitor stars. It incorporates prompt monitors on the electronic board as well as online monitors at the data acquisition stage. Assuming a false alert rate of 1 per year, this monitoring system exhibits sensitivity to pre-SN neutrinos up to a distance of approximately 1.6 (0.9) kiloparsecs and SN neutrinos up to about 370 (360) kiloparsecs for a progenitor mass of 30 solar masses, considering both normal and inverted mass ordering scenarios. The pointing ability of the CCSN is evaluated by analyzing the accumulated event anisotropy of inverse beta decay interactions from pre-SN or SN neutrinos. This, along with the early alert, can play a crucial role in facilitating follow-up multi-messenger observations of the next galactic or nearby extragalactic CCSN.

Published
2024

29. The weld seam detection method based on the infocrnet model

Author

Hui, J. P., Lian, G. Y., Wu, J. S., Hui, J. P., Lian, G. Y., and Wu, J. S.

Abstract

Weld seam detection is particularly crucial within industrial systems, as it promptly reflects the quality of product fabrication and performance, ensuring the final metallurgical product’s quality while mitigating potential losses stemming from product quality issues. This paper proposed the InfoFPN Cross Refinement Network (InfoCRNet) for the weld seam detection, achieving an accuracy rate of 98,90% and F1 score of 98,85 %.

Published
2024

30. Biomimicry of glycosaminoglycans in the bone marrow microenvironment favour the expansion of highly potent human mesenchymal stem cells

Author

Ling, L., Ren, X., Hassan, A. Binte Mohd, Mah, S., Smith, R.A., Tan, C., van Wijnen, A., Raghunath, Michael, Nurcombe, V., Hui, J., Cool, S., Ling, L., Ren, X., Hassan, A. Binte Mohd, Mah, S., Smith, R.A., Tan, C., van Wijnen, A., Raghunath, Michael, Nurcombe, V., Hui, J., and Cool, S.

Abstract

Background & Aim: Mesenchymal stem cell (MSC) therapy offers significant potential for musculoskeletal regeneration following trauma or disease. However, the low abundance of MSCs in human bone marrow aspirates necessitates further expansion in culture before their clinical application. Such ex vivo expansion can lead to a loss of stem cell characteristics, and thus unpredictable therapeutic outcomes. This has necessitated moves to develop strategies that lead to retention of MSC potency over serial passages. Studies of the MSC secretome have highlighted the importance of endogenous FGF2 for their survival and maintenance of stemness. In this study, we aimed to establish a glycosaminoglycan-rich culture microenvironment that would bind and activate endogenous FGF2 to increase the growth of multipotent MSCs suitable for therapeutic application. Methods, Results & Conclusion: We show that MSC potency and therapeutic efficacy can be enhanced by sustaining endogenous FGF2 signalling through supplementation with an affinity-selected heparan sulfate co-factor (termed HS8) generated by peptide-based affinity chromatography. Also, HS8 improves the bioavailability of FGF2, so providing MSCs access to active FGF2. This results in a significant increase in the pool of MSCs and sustained growth of multipotent MSCs over extended passaging. Importantly, this increase in cell division does not accelerate telomere loss, or adversely affect colony-forming ability, cell surface marker expression or multipotentiality. When used to treat osteochondral injury to the femoral trochlear groove of NIH nude rats, improvements in ICRS II and O'Driscoll scores were observed, with > 70% of defects treated with MSCs supplemented with HS8 achieving high scores compared with ∼ 50% for control. In a follow-on micropig osteochondral defect study, treatment with MSCs supplemented with HS8 showed significant increases in ICRS II and O'Driscoll scores compared to control. Moreover, Magnetic Resonance I

Published
2024

31. Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Author

Sterenborg, R.B.T.M., Steinbrenner, I., Li, Yong, Bujnis, M.N., Naito, T., Marouli, E., Galesloot, T.E., Babajide, O., Andreasen, L., Astrup, A., Åsvold, B.O., Bandinelli, S., Beekman, M., Beilby, J.P., Bork-Jensen, J., Boutin, T., Brody, J.A., Brown, S.J., Brumpton, B., Campbell, P.J., Cappola, A.R., Ceresini, G., Chaker, L., Chasman, D.I., Concas, M.P., Coutinho de Almeida, Rodrigo, Cross, S.M., Cucca, F., Deary, I.J., Kjaergaard, A.D., Echouffo Tcheugui, J.B., Ellervik, C., Eriksson, J.G., Ferrucci, L., Freudenberg, J., Fuchsberger, C., Gieger, C., Giulianini, F., Gögele, M., Graham, S.E., Grarup, N., Gunjača, I., Hansen, T., Harding, B.N., Harris, S.E., Haunsø, S., Hayward, C., Hui, J., Ittermann, T., Jukema, J.W., Kajantie, E., Kanters, J.K., Kårhus, L.L., Kiemeney, L.A.L.M., Kühnel, B., Lahti, J., Langenberg, C., Lapauw, B., Leese, G., Li, Shuo, Liewald, D.C.M., Linneberg, A., Lominchar, J.V.T., Luan, Jian'an, Martin, N.G., Matana, A., Meima, M.E., Meitinger, T., Meulenbelt, I., Mitchell, B.D., Møllehave, L.T., Mora, S., Naitza, S., Nauck, M., Netea-Maier, R.T., Noordam, R., Nursyifa, C., Okada, Y., Onano, S., Papadopoulou, A., Palmer, C.N.A., Pattaro, C., Pedersen, O., Peters, A., Pietzner, M., Polašek, O., Pramstaller, P.P., Psaty, B.M., Punda, A., Ray, D., Redmond, P., Richards, J.B., Ridker, P.M., Russ, T.C., Ryan, K.A., Olesen, M.S., Schultheiss, U.T., Selvin, E., Siddiqui, M.K., Teumer, A., Medici, M., Sterenborg, R.B.T.M., Steinbrenner, I., Li, Yong, Bujnis, M.N., Naito, T., Marouli, E., Galesloot, T.E., Babajide, O., Andreasen, L., Astrup, A., Åsvold, B.O., Bandinelli, S., Beekman, M., Beilby, J.P., Bork-Jensen, J., Boutin, T., Brody, J.A., Brown, S.J., Brumpton, B., Campbell, P.J., Cappola, A.R., Ceresini, G., Chaker, L., Chasman, D.I., Concas, M.P., Coutinho de Almeida, Rodrigo, Cross, S.M., Cucca, F., Deary, I.J., Kjaergaard, A.D., Echouffo Tcheugui, J.B., Ellervik, C., Eriksson, J.G., Ferrucci, L., Freudenberg, J., Fuchsberger, C., Gieger, C., Giulianini, F., Gögele, M., Graham, S.E., Grarup, N., Gunjača, I., Hansen, T., Harding, B.N., Harris, S.E., Haunsø, S., Hayward, C., Hui, J., Ittermann, T., Jukema, J.W., Kajantie, E., Kanters, J.K., Kårhus, L.L., Kiemeney, L.A.L.M., Kühnel, B., Lahti, J., Langenberg, C., Lapauw, B., Leese, G., Li, Shuo, Liewald, D.C.M., Linneberg, A., Lominchar, J.V.T., Luan, Jian'an, Martin, N.G., Matana, A., Meima, M.E., Meitinger, T., Meulenbelt, I., Mitchell, B.D., Møllehave, L.T., Mora, S., Naitza, S., Nauck, M., Netea-Maier, R.T., Noordam, R., Nursyifa, C., Okada, Y., Onano, S., Papadopoulou, A., Palmer, C.N.A., Pattaro, C., Pedersen, O., Peters, A., Pietzner, M., Polašek, O., Pramstaller, P.P., Psaty, B.M., Punda, A., Ray, D., Redmond, P., Richards, J.B., Ridker, P.M., Russ, T.C., Ryan, K.A., Olesen, M.S., Schultheiss, U.T., Selvin, E., Siddiqui, M.K., Teumer, A., and Medici, M.

Abstract

Contains fulltext : 304858.pdf (Publisher’s version ) (Open Access), To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits. The loci explained 14.1%, 6.0%, 9.5% and 1.1% of the total variation in TSH, FT4, total T3 and free T3 concentrations, respectively. Genetic correlations indicate that TSH associated loci reflect the thyroid function determined by free T3, whereas the FT4 associations represent the thyroid hormone metabolism. Polygenic risk score and Mendelian randomization analyses showed the effects of genetically determined variation in thyroid function on various clinical outcomes, including cardiovascular risk factors and diseases, autoimmune diseases, and cancer. In conclusion, our results improve the understanding of thyroid hormone physiology and highlight the pleiotropic effects of thyroid function on various diseases.

Published
2024

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Author

Abusleme, A, Adam, T, Ahmad, S, Ahmed, R, Aiello, S, Akram, M, An, F, An, Q, Andronico, G, Anfimov, N, Antonelli, V, Antoshkina, T, Asavapibhop, B, de Andre, J, Auguste, D, Balashov, N, Baldini, W, Barresi, A, Basilico, D, Baussan, E, Bellato, M, Bergnoli, A, Birkenfeld, T, Blin, S, Blum, D, Blyth, S, Bolshakova, A, Bongrand, M, Bordereau, C, Breton, D, Brigatti, A, Brugnera, R, Bruno, R, Budano, A, Buscemi, M, Busto, J, Butorov, I, Cabrera, A, Caccianiga, B, Cai, H, Cai, X, Cai, Y, Cai, Z, Callegari, R, Cammi, A, Campeny, A, Cao, C, Cao, G, Cao, J, Caruso, R, Cerna, C, Chang, J, Chang, Y, Chen, P, Chen, S, Chen, X, Chen, Y, Chen, Z, Cheng, J, Cheng, Y, Chetverikov, A, Chiesa, D, Chimenti, P, Chukanov, A, Claverie, G, Clementi, C, Clerbaux, B, Conforti Di Lorenzo, S, Corti, D, Dal Corso, F, Dalager, O, De La Taille, C, Deng, Z, Depnering, W, Diaz, M, Ding, X, Ding, Y, Dirgantara, B, Dmitrievsky, S, Dohnal, T, Dolzhikov, D, Donchenko, G, Dong, J, Doroshkevich, E, Dracos, M, Druillole, F, Du, R, Du, S, Dusini, S, Dvorak, M, Enqvist, T, Enzmann, H, Fabbri, A, Fahrendholz, U, Fan, D, Fan, L, Fang, J, Fang, W, Fargetta, M, Fedoseev, D, Feng, L, Feng, Q, Ford, R, Fournier, A, Gan, H, Gao, F, Garfagnini, A, Gavrikov, A, Giammarchi, M, Giaz, A, Giudice, N, Gonchar, M, Gong, G, Gong, H, Gornushkin, Y, Gottel, A, Grassi, M, Grewing, C, Gromov, V, Gu, M, Gu, X, Gu, Y, Guan, M, Guardone, N, Gul, M, Guo, C, Guo, J, Guo, W, Guo, X, Guo, Y, Hackspacher, P, Hagner, C, Han, R, Han, Y, Hassan, M, He, M, He, W, Heinz, T, Hellmuth, P, Heng, Y, Herrera, R, Hor, Y, Hou, S, Hsiung, Y, Hu, B, Hu, H, Hu, J, Hu, S, Hu, T, Hu, Y, Hu, Z, Huang, C, Huang, G, Huang, H, Huang, W, Huang, X, Huang, Y, Hui, J, Huo, L, Huo, W, Huss, C, Hussain, S, Ioannisian, A, Isocrate, R, Jelmini, B, Jen, K, Jeria, I, Ji, X, Jia, H, Jia, J, Jian, S, Jiang, D, Jiang, W, Jiang, X, Jin, R, Jing, X, Jollet, C, Joutsenvaara, J, Jungthawan, S, Kalousis, L, Kampmann, P, Kang, L, Karaparambil, R, Kazarian, N, Khatun, A, Khosonthongkee, K, Korablev, D, Kouzakov, K, Krasnoperov, A, Kruth, A, Kutovskiy, N, Kuusiniemi, P, Lachenmaier, T, Landini, C, Leblanc, S, Lebrin, V, Lefevre, F, Lei, R, Leitner, R, Leung, J, Li, D, Li, F, Li, G, Li, H, Li, J, Li, M, Li, N, Li, Q, Li, R, Li, S, Li, T, Li, W, Li, X, Li, Y, Li, Z, Liang, H, Liao, J, Liebau, D, Limphirat, A, Limpijumnong, S, Lin, G, Lin, S, Lin, T, Ling, J, Lippi, I, Liu, F, Liu, H, Liu, J, Liu, M, Liu, Q, Liu, R, Liu, S, Liu, X, Liu, Y, Lokhov, A, Lombardi, P, Lombardo, C, Loo, K, Lu, C, Lu, H, Lu, J, Lu, S, Lu, X, Lubsandorzhiev, B, Lubsandorzhiev, S, Ludhova, L, Lukanov, A, Luo, F, Luo, G, Luo, P, Luo, S, Luo, W, Lyashuk, V, Ma, B, Ma, Q, Ma, S, Ma, X, Maalmi, J, Malyshkin, Y, Mandujano, R, Mantovani, F, Manzali, F, Mao, X, Mao, Y, Mari, S, Marini, F, Marium, S, Martellini, C, Martin-Chassard, G, Martini, A, Mayer, M, Mayilyan, D, Mednieks, I, Meng, Y, Meregaglia, A, Meroni, E, Meyhofer, D, Mezzetto, M, Miller, J, Miramonti, L, Montini, P, Montuschi, M, Muller, A, Nastasi, M, Naumov, D, Naumova, E, Navas-Nicolas, D, Nemchenok, I, Nguyen Thi, M, Ning, F, Ning, Z, Nunokawa, H, Oberauer, L, Ochoa-Ricoux, J, Olshevskiy, A, Orestano, D, Ortica, F, Othegraven, R, Paoloni, A, Parmeggiano, S, Pei, Y, Pelliccia, N, Peng, A, Peng, H, Perrot, F, Petitjean, P, Petrucci, F, Pilarczyk, O, Pineres Rico, L, Popov, A, Poussot, P, Pratumwan, W, Previtali, E, Qi, F, Qi, M, Qian, S, Qian, X, Qian, Z, Qiao, H, Qin, Z, Qiu, S, Rajput, M, Ranucci, G, Raper, N, Re, A, Rebber, H, Rebii, A, Ren, B, Ren, J, Ricci, B, Rifai, M, Robens, M, Roche, M, Rodphai, N, Romani, A, Roskovec, B, Roth, C, Ruan, X, Rujirawat, S, Rybnikov, A, Sadovsky, A, Saggese, P, Sanfilippo, S, Sangka, A, Sanguansak, N, Sawangwit, U, Sawatzki, J, Sawy, F, Schever, M, Schwab, C, Schweizer, K, Selyunin, A, Serafini, A, Settanta, G, Settimo, M, Shao, Z, Sharov, V, Shaydurova, A, Shi, J, Shi, Y, Shutov, V, Sidorenkov, A, Simkovic, F, Sirignano, C, Siripak, J, Sisti, M, Slupecki, M, Smirnov, M, Smirnov, O, Sogo-Bezerra, T, Sokolov, S, Songwadhana, J, Soonthornthum, B, Sotnikov, A, Sramek, O, Sreethawong, W, Stahl, A, Stanco, L, Stankevich, K, Stefanik, D, Steiger, H, Steinmann, J, Sterr, T, Stock, M, Strati, V, Studenikin, A, Sun, S, Sun, X, Sun, Y, Suwonjandee, N, Szelezniak, M, Tang, J, Tang, Q, Tang, X, Tietzsch, A, Tkachev, I, Tmej, T, Torri, M, Treskov, K, Triossi, A, Troni, G, Trzaska, W, Tuve, C, Ushakov, N, van den Boom, J, van Waasen, S, Vanroyen, G, Vedin, V, Verde, G, Vialkov, M, Viaud, B, Vollbrecht, C, Volpe, C, Vorobel, V, Voronin, D, Votano, L, Walker, P, Wang, C, Wang, E, Wang, G, Wang, J, Wang, K, Wang, L, Wang, M, Wang, R, Wang, S, Wang, W, Wang, X, Wang, Y, Wang, Z, Waqas, M, Watcharangkool, A, Wei, L, Wei, W, Wei, Y, Wen, K, Wen, L, Wiebusch, C, Wong, S, Wonsak, B, Wu, D, Wu, Q, Wu, Z, Wurm, M, Wurtz, J, Wysotzki, C, Xi, Y, Xia, D, Xiao, X, Xie, X, Xie, Y, Xie, Z, Xing, Z, Xu, B, Xu, C, Xu, D, Xu, F, Xu, H, Xu, J, Xu, M, Xu, Y, Yan, B, Yan, T, Yan, W, Yan, X, Yan, Y, Yang, A, Yang, C, Yang, H, Yang, J, Yang, L, Yang, X, Yang, Y, Yao, H, Yasin, Z, Ye, J, Ye, M, Ye, Z, Yegin, U, Yermia, F, Yi, P, Yin, N, Yin, X, You, Z, Yu, B, Yu, C, Yu, H, Yu, M, Yu, X, Yu, Z, Yuan, C, Yuan, Y, Yuan, Z, Yue, B, Zafar, N, Zambanini, A, Zavadskyi, V, Zeng, S, Zeng, T, Zeng, Y, Zhan, L, Zhang, A, Zhang, F, Zhang, G, Zhang, H, Zhang, J, Zhang, P, Zhang, Q, Zhang, S, Zhang, T, Zhang, X, Zhang, Y, Zhang, Z, Zhao, F, Zhao, J, Zhao, R, Zhao, S, Zhao, T, Zheng, D, Zheng, H, Zheng, Y, Zhong, W, Zhou, J, Zhou, L, Zhou, N, Zhou, S, Zhou, T, Zhou, X, Zhu, J, Zhu, K, Zhu, Z, Zhuang, B, Zhuang, H, Zong, L, Zou, J, Abusleme A., Adam T., Ahmad S., Ahmed R., Aiello S., Akram M., An F., An Q., Andronico G., Anfimov N., Antonelli V., Antoshkina T., Asavapibhop B., de Andre J. P. A. M., Auguste D., Balashov N., Baldini W., Barresi A., Basilico D., Baussan E., Bellato M., Bergnoli A., Birkenfeld T., Blin S., Blum D., Blyth S., Bolshakova A., Bongrand M., Bordereau C., Breton D., Brigatti A., Brugnera R., Bruno R., Budano A., Buscemi M., Busto J., Butorov I., Cabrera A., Caccianiga B., Cai H., Cai X., Cai Y., Cai Z., Callegari R., Cammi A., Campeny A., Cao C., Cao G., Cao J., Caruso R., Cerna C., Chang J., Chang Y., Chen P., Chen P. -A., Chen S., Chen X., Chen Y. -W., Chen Y., Chen Z., Cheng J., Cheng Y., Chetverikov A., Chiesa D., Chimenti P., Chukanov A., Claverie G., Clementi C., Clerbaux B., Conforti Di Lorenzo S., Corti D., Dal Corso F., Dalager O., De La Taille C., Deng Z., Depnering W., Diaz M., Ding X., Ding Y., Dirgantara B., Dmitrievsky S., Dohnal T., Dolzhikov D., Donchenko G., Dong J., Doroshkevich E., Dracos M., Druillole F., Du R., Du S., Dusini S., Dvorak M., Enqvist T., Enzmann H., Fabbri A., Fahrendholz U., Fan D., Fan L., Fang J., Fang W., Fargetta M., Fedoseev D., Feng L. -C., Feng Q., Ford R., Fournier A., Gan H., Gao F., Garfagnini A., Gavrikov A., Giammarchi M., Giaz A., Giudice N., Gonchar M., Gong G., Gong H., Gornushkin Y., Gottel A., Grassi M., Grewing C., Gromov V., Gu M., Gu X., Gu Y., Guan M., Guardone N., Gul M., Guo C., Guo J., Guo W., Guo X., Guo Y., Hackspacher P., Hagner C., Han R., Han Y., Hassan M. S., He M., He W., Heinz T., Hellmuth P., Heng Y., Herrera R., Hor Y., Hou S., Hsiung Y., Hu B. -Z., Hu H., Hu J., Hu S., Hu T., Hu Y., Hu Z., Huang C., Huang G., Huang H., Huang W., Huang X., Huang Y., Hui J., Huo L., Huo W., Huss C., Hussain S., Ioannisian A., Isocrate R., Jelmini B., Jen K. -L., Jeria I., Ji X., Jia H., Jia J., Jian S., Jiang D., Jiang W., Jiang X., Jin R., Jing X., Jollet C., Joutsenvaara J., Jungthawan S., Kalousis L., Kampmann P., Kang L., Karaparambil R., Kazarian N., Khatun A., Khosonthongkee K., Korablev D., Kouzakov K., Krasnoperov A., Kruth A., Kutovskiy N., Kuusiniemi P., Lachenmaier T., Landini C., Leblanc S., Lebrin V., Lefevre F., Lei R., Leitner R., Leung J., Li D., Li F., Li G., Li H., Li J., Li M., Li N., Li Q., Li R., Li S., Li T., Li W., Li X., Li Y., Li Z., Liang H., Liao J., Liebau D., Limphirat A., Limpijumnong S., Lin G. -L., Lin S., Lin T., Ling J., Lippi I., Liu F., Liu H., Liu J., Liu M., Liu Q., Liu R., Liu S., Liu X., Liu Y., Lokhov A., Lombardi P., Lombardo C., Loo K., Lu C., Lu H., Lu J., Lu S., Lu X., Lubsandorzhiev B., Lubsandorzhiev S., Ludhova L., Lukanov A., Luo F., Luo G., Luo P., Luo S., Luo W., Lyashuk V., Ma B., Ma Q., Ma S., Ma X., Maalmi J., Malyshkin Y., Mandujano R. C., Mantovani F., Manzali F., Mao X., Mao Y., Mari S. M., Marini F., Marium S., Martellini C., Martin-Chassard G., Martini A., Mayer M., Mayilyan D., Mednieks I., Meng Y., Meregaglia A., Meroni E., Meyhofer D., Mezzetto M., Miller J., Miramonti L., Montini P., Montuschi M., Muller A., Nastasi M., Naumov D. V., Naumova E., Navas-Nicolas D., Nemchenok I., Nguyen Thi M. T., Ning F., Ning Z., Nunokawa H., Oberauer L., Ochoa-Ricoux J. P., Olshevskiy A., Orestano D., Ortica F., Othegraven R., Paoloni A., Parmeggiano S., Pei Y., Pelliccia N., Peng A., Peng H., Perrot F., Petitjean P. -A., Petrucci F., Pilarczyk O., Pineres Rico L. F., Popov A., Poussot P., Pratumwan W., Previtali E., Qi F., Qi M., Qian S., Qian X., Qian Z., Qiao H., Qin Z., Qiu S., Rajput M. U., Ranucci G., Raper N., Re A., Rebber H., Rebii A., Ren B., Ren J., Ricci B., Rifai M., Robens M., Roche M., Rodphai N., Romani A., Roskovec B., Roth C., Ruan X., Rujirawat S., Rybnikov A., Sadovsky A., Saggese P., Sanfilippo S., Sangka A., Sanguansak N., Sawangwit U., Sawatzki J., Sawy F., Schever M., Schwab C., Schweizer K., Selyunin A., Serafini A., Settanta G., Settimo M., Shao Z., Sharov V., Shaydurova A., Shi J., Shi Y., Shutov V., Sidorenkov A., Simkovic F., Sirignano C., Siripak J., Sisti M., Slupecki M., Smirnov M., Smirnov O., Sogo-Bezerra T., Sokolov S., Songwadhana J., Soonthornthum B., Sotnikov A., Sramek O., Sreethawong W., Stahl A., Stanco L., Stankevich K., Stefanik D., Steiger H., Steinmann J., Sterr T., Stock M. R., Strati V., Studenikin A., Sun S., Sun X., Sun Y., Suwonjandee N., Szelezniak M., Tang J., Tang Q., Tang X., Tietzsch A., Tkachev I., Tmej T., Torri M. D. C., Treskov K., Triossi A., Troni G., Trzaska W., Tuve C., Ushakov N., van den Boom J., van Waasen S., Vanroyen G., Vedin V., Verde G., Vialkov M., Viaud B., Vollbrecht C. M., Volpe C., Vorobel V., Voronin D., Votano L., Walker P., Wang C., Wang C. -H., Wang E., Wang G., Wang J., Wang K., Wang L., Wang M., Wang R., Wang S., Wang W., Wang X., Wang Y., Wang Z., Waqas M., Watcharangkool A., Wei L., Wei W., Wei Y., Wen K., Wen L., Wiebusch C., Wong S. C., Wonsak B., Wu D., Wu Q., Wu Z., Wurm M., Wurtz J., Wysotzki C., Xi Y., Xia D., Xiao X., Xie X., Xie Y., Xie Z., Xing Z., Xu B., Xu C., Xu D., Xu F., Xu H., Xu J., Xu M., Xu Y., Yan B., Yan T., Yan W., Yan X., Yan Y., Yang A., Yang C., Yang H., Yang J., Yang L., Yang X., Yang Y., Yao H., Yasin Z., Ye J., Ye M., Ye Z., Yegin U., Yermia F., Yi P., Yin N., Yin X., You Z., Yu B., Yu C., Yu H., Yu M., Yu X., Yu Z., Yuan C., Yuan Y., Yuan Z., Yue B., Zafar N., Zambanini A., Zavadskyi V., Zeng S., Zeng T., Zeng Y., Zhan L., Zhang A., Zhang F., Zhang G., Zhang H., Zhang J., Zhang P., Zhang Q., Zhang S., Zhang T., Zhang X., Zhang Y., Zhang Z., Zhao F., Zhao J., Zhao R., Zhao S., Zhao T., Zheng D., Zheng H., Zheng Y., Zhong W., Zhou J., Zhou L., Zhou N., Zhou S., Zhou T., Zhou X., Zhu J., Zhu K., Zhu Z., Zhuang B., Zhuang H., Zong L., Zou J., Abusleme, A, Adam, T, Ahmad, S, Ahmed, R, Aiello, S, Akram, M, An, F, An, Q, Andronico, G, Anfimov, N, Antonelli, V, Antoshkina, T, Asavapibhop, B, de Andre, J, Auguste, D, Balashov, N, Baldini, W, Barresi, A, Basilico, D, Baussan, E, Bellato, M, Bergnoli, A, Birkenfeld, T, Blin, S, Blum, D, Blyth, S, Bolshakova, A, Bongrand, M, Bordereau, C, Breton, D, Brigatti, A, Brugnera, R, Bruno, R, Budano, A, Buscemi, M, Busto, J, Butorov, I, Cabrera, A, Caccianiga, B, Cai, H, Cai, X, Cai, Y, Cai, Z, Callegari, R, Cammi, A, Campeny, A, Cao, C, Cao, G, Cao, J, Caruso, R, Cerna, C, Chang, J, Chang, Y, Chen, P, Chen, S, Chen, X, Chen, Y, Chen, Z, Cheng, J, Cheng, Y, Chetverikov, A, Chiesa, D, Chimenti, P, Chukanov, A, Claverie, G, Clementi, C, Clerbaux, B, Conforti Di Lorenzo, S, Corti, D, Dal Corso, F, Dalager, O, De La Taille, C, Deng, Z, Depnering, W, Diaz, M, Ding, X, Ding, Y, Dirgantara, B, Dmitrievsky, S, Dohnal, T, Dolzhikov, D, Donchenko, G, Dong, J, Doroshkevich, E, Dracos, M, Druillole, F, Du, R, Du, S, Dusini, S, Dvorak, M, Enqvist, T, Enzmann, H, Fabbri, A, Fahrendholz, U, Fan, D, Fan, L, Fang, J, Fang, W, Fargetta, M, Fedoseev, D, 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Abstract

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via is 36.9% ± 4.9% with a background level of events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

Published
2023

37. JUNO sensitivity to the annihilation of MeV dark matter in the galactic halo

Author

Abusleme, A, Adam, T, Ahmad, S, Ahmed, R, Aiello, S, Akram, M, Aleem, A, Alexandros, T, An, F, An, Q, Andronico, G, Anfimov, N, Antonelli, V, Antoshkina, T, Asavapibhop, B, de Andre, J, Auguste, D, Bai, W, Balashov, N, Baldini, W, Barresi, A, Basilico, D, Baussan, E, Bellato, M, Bergnoli, A, Birkenfeld, T, Blin, S, Blum, D, Blyth, S, Bolshakova, A, Bongrand, M, Bordereau, C, Breton, D, Brigatti, A, Brugnera, R, Bruno, R, Budano, A, Busto, J, Cabrera, A, Caccianiga, B, Cai, H, Cai, X, Cai, Y, Cai, Z, Callegari, R, Cammi, A, Campeny, A, Cao, C, Cao, G, Cao, J, Caruso, R, Cerna, C, Chan, C, Chang, J, Chang, Y, Chen, G, Chen, P, Chen, S, Chen, X, Chen, Y, Chen, Z, Cheng, J, Cheng, Y, Chetverikov, A, Chiesa, D, Chimenti, P, Chu, Z, Chukanov, A, Claverie, G, Clementi, C, Clerbaux, B, Di Lorenzo, S, Corti, D, Corso, F, Dalager, O, De La Taille, C, Deng, Z, Depnering, W, Diaz, M, Ding, X, Ding, Y, Dirgantara, B, Dmitrievsky, S, Dohnal, T, Dolzhikov, D, Donchenko, G, Dong, J, Doroshkevich, E, Dou, W, Dracos, M, Druillole, F, Du, R, Du, S, Dusini, S, Dvorak, M, Eck, J, Enqvist, T, Fabbri, A, Fahrendholz, U, Fan, D, Fan, L, Fang, J, Fang, W, Fargetta, M, Fedoseev, D, Fei, Z, Feng, L, Feng, Q, Ferraro, F, Ford, R, Fournier, A, Gan, H, Gao, F, Garfagnini, A, Gavrikov, A, Giammarchi, M, Giudice, N, Gonchar, M, Gong, G, Gong, H, Gornushkin, Y, Gottel, A, Grassi, M, Gromov, V, Gu, M, Gu, X, Gu, Y, Guan, M, Guan, Y, Guardone, N, Guo, C, Guo, J, Guo, W, Guo, X, Guo, Y, Hagner, C, Han, R, Han, Y, He, M, He, W, Heinz, T, Hellmuth, P, Heng, Y, Herrera, R, Hor, Y, Hou, S, Hsiung, Y, Hu, B, Hu, H, Hu, J, Hu, S, Hu, T, Hu, Y, Hu, Z, Huang, G, Huang, H, Huang, K, Huang, W, Huang, X, Huang, Y, Hui, J, Huo, L, Huo, W, Huss, C, Hussain, S, Ioannisian, A, Isocrate, R, Jelmini, B, Jeria, I, Ji, X, Jia, H, Jia, J, Jian, S, Jiang, D, Jiang, W, Jiang, X, Jing, X, Jollet, C, Joutsenvaara, J, Kalousis, L, Kampmann, P, Kang, L, Karaparambil, R, Kazarian, N, Khatun, A, Khosonthongkee, K, Korablev, D, Kouzakov, K, Krasnoperov, A, Kutovskiy, N, Kuusiniemi, P, Lachenmaier, T, Landini, C, Leblanc, S, Lebrin, V, Lefevre, F, Lei, R, Leitner, R, Leung, J, Li, D, Li, F, Li, G, Li, H, Li, M, Li, N, Li, Q, Li, R, Li, S, Li, T, Li, W, Li, X, Li, Y, Li, Z, Liang, H, Liao, J, Limphirat, A, Lin, G, Lin, S, Lin, T, Ling, J, Lippi, I, Liu, F, Liu, H, Liu, J, Liu, M, Liu, Q, Liu, R, Liu, S, Liu, X, Liu, Y, Lokhov, A, Lombardi, P, Lombardo, C, Loo, K, Lu, C, Lu, H, Lu, J, Lu, P, Lu, S, Lubsandorzhiev, B, Lubsandorzhiev, S, Ludhova, L, Lukanov, A, Luo, D, Luo, F, Luo, G, Luo, S, Luo, W, Luo, X, Lyashuk, V, Ma, B, Ma, Q, Ma, S, Ma, X, Maalmi, J, Magoni, M, Mai, J, Malyshkin, Y, Mandujano, R, Mantovani, F, Mao, X, Mao, Y, Mari, S, Marini, F, Martellini, C, Martin-Chassard, G, Martini, A, Mayer, M, Mayilyan, D, Mednieks, I, Meinusch, A, Meng, Y, Meregaglia, A, Meroni, E, Meyhofer, D, Mezzetto, M, Miller, J, Miramonti, L, Molla, M, Montini, P, Montuschi, M, Muller, A, Nastasi, M, Naumov, D, Naumova, E, Navas-Nicolas, D, Nemchenok, I, Thi, M, Ning, F, Ning, Z, Nunokawa, H, Oberauer, L, Ochoa-Ricoux, J, Olshevskiy, A, Orestano, D, Ortica, F, Othegraven, R, Paoloni, A, Parmeggiano, S, Pei, Y, Pelicci, L, Pelliccia, N, Peng, A, Peng, H, Peng, Y, Peng, Z, Perrot, F, Petitjean, P, Petrucci, F, Pilarczyk, O, Rico, L, Popov, A, Poussot, P, Previtali, E, Qi, F, Qi, M, Qian, S, Qian, X, Qian, Z, Qiao, H, Qin, Z, Qiu, S, Ranucci, G, Raper, N, Rasheed, R, Re, A, Rebber, H, Rebii, A, Redchuk, M, Ren, B, Ren, J, Ricci, B, Rifai, M, Roche, M, Rodphai, N, Romani, A, Roskovec, B, Ruan, X, Rybnikov, A, Sadovsky, A, Saggese, P, Sanfilippo, S, Sangka, A, Sawangwit, U, Sawatzki, J, Schever, M, Schwab, C, Schweizer, K, Selyunin, A, Serafini, A, Settanta, G, Settimo, M, Shao, Z, Sharov, V, Shaydurova, A, Shi, J, Shi, Y, Shutov, V, Sidorenkov, A, Simkovic, F, Sirignano, C, Siripak, J, Sisti, M, Slupecki, M, Smirnov, M, Smirnov, O, Sogo-Bezerra, T, Sokolov, S, Songwadhana, J, Soonthornthum, B, Sotnikov, A, Sramek, O, Sreethawong, W, Stahl, A, Stanco, L, Stankevich, K, Stefanik, D, Steiger, H, Steinmann, J, Sterr, T, Stock, M, Strati, V, Studenikin, A, Su, J, Sun, S, Sun, X, Sun, Y, Sun, Z, Suwonjandee, N, Szelezniak, M, Tang, J, Tang, Q, Tang, X, Hariharan, V, Theisen, E, Tietzsch, A, Tkachev, I, Tmej, T, Torri, M, Treskov, K, Triossi, A, Troni, G, Trzaska, W, Tuve, C, Ushakov, N, Vedin, V, Verde, G, Vialkov, M, Viaud, B, Vollbrecht, C, Volpe, C, Sturm, K, Vorobel, V, Voronin, D, Votano, L, Walker, P, Wang, C, Wang, E, Wang, G, Wang, J, Wang, L, Wang, M, Wang, R, Wang, S, Wang, W, Wang, X, Wang, Y, Weng, Y, Wang, Z, Watcharangkool, A, Wei, W, Wei, Y, Wen, K, Wen, L, Weng, J, Wiebusch, C, Wong, S, Wonsak, B, Wu, D, Wu, Q, Wu, Z, Wurm, M, Wurtz, J, Wysotzki, C, Xi, Y, Xia, D, Xiao, X, Xie, X, Xie, Y, Xie, Z, Xin, Z, Xing, Z, Xu, B, Xu, C, Xu, D, Xu, F, Xu, H, Xu, J, Xu, M, Xu, Y, Yan, B, Yan, Q, Yan, T, Yan, W, Yan, X, Yan, Y, Yang, C, Yang, H, Yang, J, Yang, L, Yang, X, Yang, Y, Yeng, Y, Yao, H, Ye, J, Ye, M, Ye, Z, Yermia, F, You, Z, Yu, B, Yu, C, Yu, H, Yu, M, Yu, X, Yu, Z, Yuan, C, Yuan, Y, Yuan, Z, Yue, B, Zafar, N, Zavadskyi, V, Zeng, S, Zeng, T, Zeng, Y, Zhan, L, Zhang, A, Zhang, B, Zhang, F, Zhang, G, Zhang, H, Zhang, J, Zhang, M, Zhang, P, Zhang, Q, Zhang, S, Zhang, T, Zhang, X, Zhang, Y, Zhang, Z, Zhao, F, Zhao, J, Zhao, R, Zhao, S, Zheng, D, Zheng, H, Zheng, Y, Zhong, W, Zhou, J, Zhou, L, Zhou, N, Zhou, S, Zhou, T, Zhou, X, Zhu, J, Zhu, K, Zhu, Z, Zhuang, B, Zhuang, H, Zong, L, Zou, J, Zwickel, S, Abusleme A., Adam T., Ahmad S., Ahmed R., Aiello S., Akram M., Aleem A., Alexandros T., An F., An Q., Andronico G., Anfimov N., Antonelli V., Antoshkina T., Asavapibhop B., de Andre J. P. A. M., Auguste D., Bai W., Balashov N., Baldini W., Barresi A., Basilico D., Baussan E., Bellato M., Bergnoli A., Birkenfeld T., Blin S., Blum D., Blyth S., Bolshakova A., Bongrand M., Bordereau C., Breton D., Brigatti A., Brugnera R., Bruno R., Budano A., Busto J., Cabrera A., Caccianiga B., Cai H., Cai X., Cai Y., Cai Z., Callegari R., Cammi A., Campeny A., Cao C., Cao G., Cao J., Caruso R., Cerna C., Chan C., Chang J., Chang Y., Chen G., Chen P., Chen P. -A., Chen S., Chen X., Chen Y., Chen Z., Cheng J., Cheng Y., Cheng Y. C., Chetverikov A., Chiesa D., Chimenti P., Chu Z., Chukanov A., Claverie G., Clementi C., Clerbaux B., Di Lorenzo S. C., Corti D., Corso F. D., Dalager O., De La Taille C., Deng Z., Depnering W., Diaz M., Ding X., Ding Y., Dirgantara B., Dmitrievsky S., Dohnal T., Dolzhikov D., Donchenko G., Dong J., Doroshkevich E., Dou W., Dracos M., Druillole F., Du R., Du S., Dusini S., Dvorak M., Eck J., Enqvist T., Fabbri A., Fahrendholz U., Fan D., Fan L., Fang J., Fang W., Fargetta M., Fedoseev D., Fei Z., Feng L. -C., Feng Q., Ferraro F., Ford R., Fournier A., Gan H., Gao F., Garfagnini A., Gavrikov A., Giammarchi M., Giudice N., Gonchar M., Gong G., Gong H., Gornushkin Y., Gottel A., Grassi M., Gromov V., Gu M., Gu X., Gu Y., Guan M., Guan Y., Guardone N., Guo C., Guo J., Guo W., Guo X., Guo Y., Hagner C., Han R., Han Y., He M., He W., Heinz T., Hellmuth P., Heng Y., Herrera R., Hor Y., Hou S., Hsiung Y., Hu B. -Z., Hu H., Hu J., Hu S., Hu T., Hu Y., Hu Z., Huang G., Huang H., Huang K., Huang W., Huang X., Huang Y., Hui J., Huo L., Huo W., Huss C., Hussain S., Ioannisian A., Isocrate R., Jelmini B., Jeria I., Ji X., Jia H., Jia J., Jian S., Jiang D., Jiang W., Jiang X., Jing X., Jollet C., Joutsenvaara J., Kalousis L., Kampmann P., Kang L., Karaparambil R., Kazarian N., Khatun A., Khosonthongkee K., Korablev D., Kouzakov K., Krasnoperov A., Kutovskiy N., Kuusiniemi P., Lachenmaier T., Landini C., Leblanc S., Lebrin V., Lefevre F., Lei R., Leitner R., Leung J., Li D., Li F., Li G., Li H., Li M., Li N., Li Q., Li R., Li S., Li T., Li W., Li X., Li Y., Li Z., Liang H., Liao J., Limphirat A., Lin G. -L., Lin S., Lin T., Ling J., Lippi I., Liu F., Liu H., Liu J., Liu M., Liu Q., Liu R., Liu S., Liu X., Liu Y., Lokhov A., Lombardi P., Lombardo C., Loo K., Lu C., Lu H., Lu J., Lu P., Lu S., Lubsandorzhiev B., Lubsandorzhiev S., Ludhova L., Lukanov A., Luo D., Luo F., Luo G., Luo S., Luo W., Luo X., Lyashuk V., Ma B., Ma Q., Ma S., Ma X., Maalmi J., Magoni M., Mai J., Malyshkin Y., Mandujano R. C., Mantovani F., Mao X., Mao Y., Mari S. M., Marini F., Martellini C., Martin-Chassard G., Martini A., Mayer M., Mayilyan D., Mednieks I., Meinusch A., Meng Y., Meregaglia A., Meroni E., Meyhofer D., Mezzetto M., Miller J., Miramonti L., Molla M. C., Montini P., Montuschi M., Muller A., Nastasi M., Naumov D. V., Naumova E., Navas-Nicolas D., Nemchenok I., Thi M. T. N., Ning F., Ning Z., Nunokawa H., Oberauer L., Ochoa-Ricoux J. P., Olshevskiy A., Orestano D., Ortica F., Othegraven R., Paoloni A., Parmeggiano S., Pei Y., Pelicci L., Pelliccia N., Peng A., Peng H., Peng Y., Peng Z., Perrot F., Petitjean P. -A., Petrucci F., Pilarczyk O., Rico L. F. P., Popov A., Poussot P., Previtali E., Qi F., Qi M., Qian S., Qian X., Qian Z., Qiao H., Qin Z., Qiu S., Ranucci G., Raper N., Rasheed R., Re A., Rebber H., Rebii A., Redchuk M., Ren B., Ren J., Ricci B., Rifai M., Roche M., Rodphai N., Romani A., Roskovec B., Ruan X., Rybnikov A., Sadovsky A., Saggese P., Sanfilippo S., Sangka A., Sawangwit U., Sawatzki J., Schever M., Schwab C., Schweizer K., Selyunin A., Serafini A., Settanta G., Settimo M., Shao Z., Sharov V., Shaydurova A., Shi J., Shi Y., Shutov V., Sidorenkov A., Simkovic F., Sirignano C., Siripak J., Sisti M., Slupecki M., Smirnov M., Smirnov O., Sogo-Bezerra T., Sokolov S., Songwadhana J., Soonthornthum B., Sotnikov A., Sramek O., Sreethawong W., Stahl A., Stanco L., Stankevich K., Stefanik D., Steiger H., Steinmann J., Sterr T., Stock M. R., Strati V., Studenikin A., Su J., Sun S., Sun X., Sun Y., Sun Z., Suwonjandee N., Szelezniak M., Tang J., Tang Q., Tang X., Hariharan V. T., Theisen E., Tietzsch A., Tkachev I., Tmej T., Torri M. D. C., Treskov K., Triossi A., Troni G., Trzaska W., Tuve C., Ushakov N., Vedin V., Verde G., Vialkov M., Viaud B., Vollbrecht C. M., Volpe C., Sturm K. V., Vorobel V., Voronin D., Votano L., Walker P., Wang C., Wang C. -H., Wang E., Wang G., Wang J., Wang L., Wang M., Wang R., Wang S., Wang W., Wang X., Wang Y., Weng Y., Wang Z., Watcharangkool A., Wei W., Wei Y., Wen K., Wen L., Weng J., Wiebusch C., Wong S. C. -F., Wonsak B., Wu D., Wu Q., Wu Z., Wurm M., Wurtz J., Wysotzki C., Xi Y., Xia D., Xiao X., Xie X., Xie Y., Xie Z., Xin Z., Xing Z., Xu B., Xu C., Xu D., Xu F., Xu H., Xu J., Xu M., Xu Y., Yan B., Yan Q., Yan T., Yan W., Yan X., Yan Y., Yang C., Yang H., Yang J., Yang L., Yang X., Yang Y., Yeng Y., Yao H., Ye J., Ye M., Ye Z., Yermia F., You Z., Yu B., Yu C., Yu H., Yu M., Yu X., Yu Z., Yuan C., Yuan Y., Yuan Z., Yue B., Zafar N., Zavadskyi V., Zeng S., Zeng T., Zeng Y., Zhan L., Zhang A., Zhang B., Zhang F., Zhang G., Zhang H., Zhang J., Zhang M., Zhang P., Zhang Q., Zhang S., Zhang T., Zhang X., Zhang Y., Zhang Z., Zhao F., Zhao J., Zhao R., Zhao S., Zheng D., Zheng H., Zheng Y., Zhong W., Zhou J., Zhou L., Zhou N., Zhou S., Zhou T., Zhou X., Zhu J., Zhu K., Zhu Z., Zhuang B., Zhuang H., Zong L., Zou J., Zwickel S., Abusleme, A, Adam, T, Ahmad, S, Ahmed, R, Aiello, S, Akram, M, Aleem, A, Alexandros, T, An, F, An, Q, Andronico, G, Anfimov, N, Antonelli, V, Antoshkina, T, Asavapibhop, B, de Andre, J, Auguste, D, Bai, W, Balashov, N, Baldini, W, Barresi, A, Basilico, D, Baussan, E, Bellato, M, Bergnoli, A, Birkenfeld, T, Blin, S, Blum, D, Blyth, S, Bolshakova, A, Bongrand, M, Bordereau, C, Breton, D, Brigatti, A, Brugnera, R, Bruno, R, Budano, A, Busto, J, Cabrera, A, Caccianiga, B, Cai, H, Cai, X, Cai, Y, Cai, Z, Callegari, R, Cammi, A, Campeny, A, Cao, C, Cao, G, Cao, J, Caruso, R, Cerna, C, Chan, C, Chang, J, Chang, Y, Chen, G, Chen, P, Chen, S, Chen, X, Chen, Y, Chen, Z, Cheng, J, Cheng, Y, Chetverikov, A, Chiesa, D, Chimenti, P, Chu, Z, Chukanov, A, Claverie, G, Clementi, C, Clerbaux, B, Di Lorenzo, S, Corti, D, Corso, F, Dalager, O, De La Taille, C, Deng, Z, Depnering, W, Diaz, M, Ding, X, Ding, Y, Dirgantara, B, Dmitrievsky, S, Dohnal, T, Dolzhikov, D, Donchenko, G, Dong, J, Doroshkevich, E, Dou, W, Dracos, M, Druillole, F, Du, R, Du, S, Dusini, S, Dvorak, M, Eck, J, Enqvist, T, Fabbri, A, Fahrendholz, U, Fan, D, Fan, L, Fang, J, Fang, W, Fargetta, M, Fedoseev, D, Fei, Z, Feng, L, Feng, Q, Ferraro, F, Ford, R, Fournier, A, Gan, H, Gao, F, Garfagnini, A, Gavrikov, A, Giammarchi, M, Giudice, N, Gonchar, M, Gong, G, Gong, H, Gornushkin, Y, Gottel, A, Grassi, M, Gromov, V, Gu, M, Gu, X, Gu, Y, Guan, M, Guan, Y, Guardone, N, Guo, C, Guo, J, Guo, W, Guo, X, Guo, Y, Hagner, C, Han, R, Han, Y, He, M, He, W, Heinz, T, Hellmuth, P, Heng, Y, Herrera, R, Hor, Y, Hou, S, Hsiung, Y, Hu, B, Hu, H, Hu, J, Hu, S, Hu, T, Hu, Y, Hu, Z, Huang, G, Huang, H, Huang, K, Huang, W, Huang, X, Huang, Y, Hui, J, Huo, L, Huo, W, Huss, C, Hussain, S, Ioannisian, A, Isocrate, R, Jelmini, B, Jeria, I, Ji, X, Jia, H, Jia, J, Jian, S, Jiang, D, Jiang, W, Jiang, X, Jing, X, Jollet, C, Joutsenvaara, J, Kalousis, L, Kampmann, P, Kang, L, Karaparambil, R, Kazarian, N, Khatun, A, Khosonthongkee, K, Korablev, D, Kouzakov, K, Krasnoperov, A, Kutovskiy, N, Kuusiniemi, P, Lachenmaier, T, Landini, C, Leblanc, S, Lebrin, V, Lefevre, F, Lei, R, Leitner, R, Leung, J, Li, D, Li, F, Li, G, Li, H, Li, M, Li, N, Li, Q, Li, R, Li, S, Li, T, Li, W, Li, X, Li, Y, Li, Z, Liang, H, Liao, J, Limphirat, A, Lin, G, Lin, S, Lin, T, Ling, J, Lippi, I, Liu, F, Liu, H, Liu, J, Liu, M, Liu, Q, Liu, R, Liu, S, Liu, X, Liu, Y, Lokhov, A, Lombardi, P, Lombardo, C, Loo, K, Lu, C, Lu, H, Lu, J, Lu, P, Lu, S, Lubsandorzhiev, B, Lubsandorzhiev, S, Ludhova, L, Lukanov, A, Luo, D, Luo, F, Luo, G, Luo, S, Luo, W, Luo, X, Lyashuk, V, Ma, B, Ma, Q, Ma, S, Ma, X, Maalmi, J, Magoni, M, Mai, J, Malyshkin, Y, Mandujano, R, Mantovani, F, Mao, X, Mao, Y, Mari, S, Marini, F, Martellini, C, Martin-Chassard, G, Martini, A, Mayer, M, Mayilyan, D, Mednieks, I, Meinusch, A, Meng, Y, Meregaglia, A, Meroni, E, Meyhofer, D, Mezzetto, M, Miller, J, Miramonti, L, Molla, M, Montini, P, Montuschi, M, Muller, A, Nastasi, M, Naumov, D, Naumova, E, Navas-Nicolas, D, Nemchenok, I, Thi, M, Ning, F, Ning, Z, Nunokawa, H, Oberauer, L, Ochoa-Ricoux, J, Olshevskiy, A, Orestano, D, Ortica, F, Othegraven, R, Paoloni, A, Parmeggiano, S, Pei, Y, Pelicci, L, Pelliccia, N, Peng, A, Peng, H, Peng, Y, Peng, Z, Perrot, F, Petitjean, P, Petrucci, F, Pilarczyk, O, Rico, L, Popov, A, Poussot, P, Previtali, E, Qi, F, Qi, M, Qian, S, Qian, X, Qian, Z, Qiao, H, Qin, Z, Qiu, S, Ranucci, G, Raper, N, Rasheed, R, Re, A, Rebber, H, Rebii, A, Redchuk, M, Ren, B, Ren, J, Ricci, B, Rifai, M, Roche, M, Rodphai, N, Romani, A, Roskovec, B, Ruan, X, Rybnikov, A, Sadovsky, A, Saggese, P, Sanfilippo, S, Sangka, A, Sawangwit, U, Sawatzki, J, Schever, M, Schwab, C, Schweizer, K, Selyunin, A, Serafini, A, Settanta, G, Settimo, M, Shao, Z, Sharov, V, Shaydurova, A, Shi, J, Shi, Y, Shutov, V, Sidorenkov, A, Simkovic, F, Sirignano, C, Siripak, J, Sisti, M, Slupecki, M, Smirnov, M, Smirnov, O, Sogo-Bezerra, T, Sokolov, S, Songwadhana, J, Soonthornthum, B, Sotnikov, A, Sramek, O, Sreethawong, W, Stahl, A, Stanco, L, Stankevich, K, Stefanik, D, Steiger, H, Steinmann, J, Sterr, T, Stock, M, Strati, V, Studenikin, A, Su, J, Sun, S, Sun, X, Sun, Y, Sun, Z, Suwonjandee, N, Szelezniak, M, Tang, J, Tang, Q, Tang, X, Hariharan, V, Theisen, E, Tietzsch, A, Tkachev, I, Tmej, T, Torri, M, Treskov, K, Triossi, A, Troni, G, Trzaska, W, Tuve, C, Ushakov, N, Vedin, V, Verde, G, Vialkov, M, Viaud, B, Vollbrecht, C, Volpe, C, Sturm, K, Vorobel, V, Voronin, D, Votano, L, Walker, P, Wang, C, Wang, E, Wang, G, Wang, J, Wang, L, Wang, M, Wang, R, Wang, S, Wang, W, Wang, X, Wang, Y, Weng, Y, Wang, Z, Watcharangkool, A, Wei, W, Wei, Y, Wen, K, Wen, L, Weng, J, Wiebusch, C, Wong, S, Wonsak, B, Wu, D, Wu, Q, Wu, Z, Wurm, M, Wurtz, J, Wysotzki, C, Xi, Y, Xia, D, Xiao, X, Xie, X, Xie, Y, Xie, Z, Xin, Z, Xing, Z, Xu, B, Xu, C, Xu, D, Xu, F, Xu, H, Xu, J, Xu, M, Xu, Y, Yan, B, Yan, Q, Yan, T, Yan, W, Yan, X, Yan, Y, Yang, C, Yang, H, Yang, J, Yang, L, Yang, X, Yang, Y, Yeng, Y, Yao, H, Ye, J, Ye, M, Ye, Z, Yermia, F, You, Z, Yu, B, Yu, C, Yu, H, Yu, M, Yu, X, Yu, Z, Yuan, C, Yuan, Y, Yuan, Z, Yue, B, Zafar, N, Zavadskyi, V, Zeng, S, Zeng, T, Zeng, Y, Zhan, L, Zhang, A, Zhang, B, Zhang, F, Zhang, G, Zhang, H, Zhang, J, Zhang, M, Zhang, P, Zhang, Q, Zhang, S, Zhang, T, Zhang, X, Zhang, Y, Zhang, Z, Zhao, F, Zhao, J, Zhao, R, Zhao, S, Zheng, D, Zheng, H, Zheng, Y, Zhong, W, Zhou, J, Zhou, L, Zhou, N, Zhou, S, Zhou, T, Zhou, X, Zhu, J, Zhu, K, Zhu, Z, Zhuang, B, Zhuang, H, Zong, L, Zou, J, Zwickel, S, Abusleme A., Adam T., Ahmad S., Ahmed R., Aiello S., Akram M., Aleem A., Alexandros T., An F., An Q., Andronico G., Anfimov N., Antonelli V., Antoshkina T., Asavapibhop B., de Andre J. P. A. M., Auguste D., Bai W., Balashov N., Baldini W., Barresi A., Basilico D., Baussan E., Bellato M., Bergnoli A., Birkenfeld T., Blin S., Blum D., Blyth S., Bolshakova A., Bongrand M., Bordereau C., Breton D., Brigatti A., Brugnera R., Bruno R., Budano A., Busto J., Cabrera A., Caccianiga B., Cai H., Cai X., Cai Y., Cai Z., Callegari R., Cammi A., Campeny A., Cao C., Cao G., Cao J., Caruso R., Cerna C., Chan C., Chang J., Chang Y., Chen G., Chen P., Chen P. -A., Chen S., Chen X., Chen Y., Chen Z., Cheng J., Cheng Y., Cheng Y. C., Chetverikov A., Chiesa D., Chimenti P., Chu Z., Chukanov A., Claverie G., Clementi C., Clerbaux B., Di Lorenzo S. C., Corti D., Corso F. D., Dalager O., De La Taille C., Deng Z., Depnering W., Diaz M., Ding X., Ding Y., Dirgantara B., Dmitrievsky S., Dohnal T., Dolzhikov D., Donchenko G., Dong J., Doroshkevich E., Dou W., Dracos M., Druillole F., Du R., Du S., Dusini S., Dvorak M., Eck J., Enqvist T., Fabbri A., Fahrendholz U., Fan D., Fan L., Fang J., Fang W., Fargetta M., Fedoseev D., Fei Z., Feng L. -C., Feng Q., Ferraro F., Ford R., Fournier A., Gan H., Gao F., Garfagnini A., Gavrikov A., Giammarchi M., Giudice N., Gonchar M., Gong G., Gong H., Gornushkin Y., Gottel A., Grassi M., Gromov V., Gu M., Gu X., Gu Y., Guan M., Guan Y., Guardone N., Guo C., Guo J., Guo W., Guo X., Guo Y., Hagner C., Han R., Han Y., He M., He W., Heinz T., Hellmuth P., Heng Y., Herrera R., Hor Y., Hou S., Hsiung Y., Hu B. -Z., Hu H., Hu J., Hu S., Hu T., Hu Y., Hu Z., Huang G., Huang H., Huang K., Huang W., Huang X., Huang Y., Hui J., Huo L., Huo W., Huss C., Hussain S., Ioannisian A., Isocrate R., Jelmini B., Jeria I., Ji X., Jia H., Jia J., Jian S., Jiang D., Jiang W., Jiang X., Jing X., Jollet C., Joutsenvaara J., Kalousis L., Kampmann P., Kang L., Karaparambil R., Kazarian N., Khatun A., Khosonthongkee K., Korablev D., Kouzakov K., Krasnoperov A., Kutovskiy N., Kuusiniemi P., Lachenmaier T., Landini C., Leblanc S., Lebrin V., Lefevre F., Lei R., Leitner R., Leung J., Li D., Li F., Li G., Li H., Li M., Li N., Li Q., Li R., Li S., Li T., Li W., Li X., Li Y., Li Z., Liang H., Liao J., Limphirat A., Lin G. -L., Lin S., Lin T., Ling J., Lippi I., Liu F., Liu H., Liu J., Liu M., Liu Q., Liu R., Liu S., Liu X., Liu Y., Lokhov A., Lombardi P., Lombardo C., Loo K., Lu C., Lu H., Lu J., Lu P., Lu S., Lubsandorzhiev B., Lubsandorzhiev S., Ludhova L., Lukanov A., Luo D., Luo F., Luo G., Luo S., Luo W., Luo X., Lyashuk V., Ma B., Ma Q., Ma S., Ma X., Maalmi J., Magoni M., Mai J., Malyshkin Y., Mandujano R. C., Mantovani F., Mao X., Mao Y., Mari S. M., Marini F., Martellini C., Martin-Chassard G., Martini A., Mayer M., Mayilyan D., Mednieks I., Meinusch A., Meng Y., Meregaglia A., Meroni E., Meyhofer D., Mezzetto M., Miller J., Miramonti L., Molla M. C., Montini P., Montuschi M., Muller A., Nastasi M., Naumov D. V., Naumova E., Navas-Nicolas D., Nemchenok I., Thi M. T. N., Ning F., Ning Z., Nunokawa H., Oberauer L., Ochoa-Ricoux J. P., Olshevskiy A., Orestano D., Ortica F., Othegraven R., Paoloni A., Parmeggiano S., Pei Y., Pelicci L., Pelliccia N., Peng A., Peng H., Peng Y., Peng Z., Perrot F., Petitjean P. -A., Petrucci F., Pilarczyk O., Rico L. F. P., Popov A., Poussot P., Previtali E., Qi F., Qi M., Qian S., Qian X., Qian Z., Qiao H., Qin Z., Qiu S., Ranucci G., Raper N., Rasheed R., Re A., Rebber H., Rebii A., Redchuk M., Ren B., Ren J., Ricci B., Rifai M., Roche M., Rodphai N., Romani A., Roskovec B., Ruan X., Rybnikov A., Sadovsky A., Saggese P., Sanfilippo S., Sangka A., Sawangwit U., Sawatzki J., Schever M., Schwab C., Schweizer K., Selyunin A., Serafini A., Settanta G., Settimo M., Shao Z., Sharov V., Shaydurova A., Shi J., Shi Y., Shutov V., Sidorenkov A., Simkovic F., Sirignano C., Siripak J., Sisti M., Slupecki M., Smirnov M., Smirnov O., Sogo-Bezerra T., Sokolov S., Songwadhana J., Soonthornthum B., Sotnikov A., Sramek O., Sreethawong W., Stahl A., Stanco L., Stankevich K., Stefanik D., Steiger H., Steinmann J., Sterr T., Stock M. R., Strati V., Studenikin A., Su J., Sun S., Sun X., Sun Y., Sun Z., Suwonjandee N., Szelezniak M., Tang J., Tang Q., Tang X., Hariharan V. T., Theisen E., Tietzsch A., Tkachev I., Tmej T., Torri M. D. C., Treskov K., Triossi A., Troni G., Trzaska W., Tuve C., Ushakov N., Vedin V., Verde G., Vialkov M., Viaud B., Vollbrecht C. M., Volpe C., Sturm K. V., Vorobel V., Voronin D., Votano L., Walker P., Wang C., Wang C. -H., Wang E., Wang G., Wang J., Wang L., Wang M., Wang R., Wang S., Wang W., Wang X., Wang Y., Weng Y., Wang Z., Watcharangkool A., Wei W., Wei Y., Wen K., Wen L., Weng J., Wiebusch C., Wong S. C. -F., Wonsak B., Wu D., Wu Q., Wu Z., Wurm M., Wurtz J., Wysotzki C., Xi Y., Xia D., Xiao X., Xie X., Xie Y., Xie Z., Xin Z., Xing Z., Xu B., Xu C., Xu D., Xu F., Xu H., Xu J., Xu M., Xu Y., Yan B., Yan Q., Yan T., Yan W., Yan X., Yan Y., Yang C., Yang H., Yang J., Yang L., Yang X., Yang Y., Yeng Y., Yao H., Ye J., Ye M., Ye Z., Yermia F., You Z., Yu B., Yu C., Yu H., Yu M., Yu X., Yu Z., Yuan C., Yuan Y., Yuan Z., Yue B., Zafar N., Zavadskyi V., Zeng S., Zeng T., Zeng Y., Zhan L., Zhang A., Zhang B., Zhang F., Zhang G., Zhang H., Zhang J., Zhang M., Zhang P., Zhang Q., Zhang S., Zhang T., Zhang X., Zhang Y., Zhang Z., Zhao F., Zhao J., Zhao R., Zhao S., Zheng D., Zheng H., Zheng Y., Zhong W., Zhou J., Zhou L., Zhou N., Zhou S., Zhou T., Zhou X., Zhu J., Zhu K., Zhu Z., Zhuang B., Zhuang H., Zong L., Zou J., and Zwickel S.

Abstract

We discuss JUNO sensitivity to the annihilation of MeV dark matter in the galactic halo via detecting inverse beta decay reactions of electron anti-neutrinos resulting from the annihilation. We study possible backgrounds to the signature, including the reactor neutrinos, diffuse supernova neutrino background, charged- and neutral-current interactions of atmospheric neutrinos, backgrounds from muon-induced fast neutrons and cosmogenic isotopes. A fiducial volume cut, as well as the pulse shape discrimination and the muon veto are applied to suppress the above backgrounds. It is shown that JUNO sensitivity to the thermally averaged dark matter annihilation rate in 10 years of exposure would be significantly better than the present-day best limit set by Super-Kamiokande and would be comparable to that expected by Hyper-Kamiokande.

Published
2023

38. JUNO sensitivity to 7Be, pep, and CNO solar neutrinos

Author

Abusleme, A, Adam, T, Ahmad, S, Ahmed, R, Aiello, S, Akram, M, Aleem, A, Alexandros, T, An, F, An, Q, Andronico, G, Anfimov, N, Antonelli, V, Antoshkina, T, Asavapibhop, B, de Andre, J, Auguste, D, Bai, W, Balashov, N, Baldini, W, Barresi, A, Basilico, D, Baussan, E, Bellato, M, Beretta, M, Bergnoli, A, Bick, D, Bieger, L, Biktemerova, S, Birkenfeld, T, Blum, D, Blyth, S, Bolshakova, A, Bongrand, M, Bordereau, C, Breton, D, Brigatti, A, Brugnera, R, Bruno, R, Budano, A, Busto, J, Cabrera, A, Caccianiga, B, Cai, H, Cai, X, Cai, Y, Cai, Z, Callier, S, Cammi, A, Campeny, A, Cao, C, Cao, G, Cao, J, Caruso, R, Cerna, C, Cerrone, V, Chan, C, Chang, J, Chang, Y, Chen, C, Chen, G, Chen, P, Chen, S, Chen, Y, Chen, Z, Cheng, J, Cheng, Y, Chepurnov, A, Chetverikov, A, Chiesa, D, Chimenti, P, Chu, Z, Chukanov, A, Claverie, G, Clementi, C, Clerbaux, B, Molla, M, Di Lorenzo, S, Coppi, A, Corti, D, Csakli, S, Dal Corso, F, Dalager, O, Datta, J, De La Taille, C, Deng, Z, Depnering, W, Ding, X, Ding, Y, Dirgantara, B, Dittrich, C, Dmitrievsky, S, Dohnal, T, Dolzhikov, D, Donchenko, G, Dong, J, Doroshkevich, E, Dou, W, Dracos, M, Druillole, F, Du, R, Du, S, Dugas, K, Dusini, S, Duyang, H, Eck, J, Enqvist, T, Fabbri, A, Fahrendholz, U, Fan, L, Fang, J, Fang, W, Fargetta, M, Fedoseev, D, Fei, Z, Feng, L, Feng, Q, Ferraro, F, Fournier, A, Gan, H, Gao, F, Garfagnini, A, Gavrikov, A, Giammarchi, M, Giudice, N, Gonchar, M, Gong, G, Gong, H, Gornushkin, Y, Gottel, A, Grassi, M, Gromov, M, Gromov, V, Gu, M, Gu, X, Gu, Y, Guan, M, Guan, Y, Guardone, N, Guo, C, Guo, W, Guo, X, Hagner, C, Han, R, Han, Y, He, M, He, W, Heinz, T, Hellmuth, P, Heng, Y, Herrera, R, Hor, Y, Hou, S, Hsiung, Y, Hu, B, Hu, H, Hu, J, Hu, S, Hu, T, Hu, Y, Hu, Z, Huang, G, Huang, H, Huang, J, Huang, K, Huang, W, Huang, X, Huang, Y, Hui, J, Huo, L, Huo, W, Huss, C, Hussain, S, Imbert, L, Ioannisian, A, Isocrate, R, Jelmini, B, Jeria, I, Ji, X, Jia, H, Jia, J, Jian, S, Jiang, C, Jiang, D, Jiang, W, Jiang, X, Jing, X, Jollet, C, Kampmann, P, Kang, L, Karaparambil, R, Kazarian, N, Khan, A, Khatun, A, Khosonthongkee, K, Korablev, D, Kouzakov, K, Krasnoperov, A, Kuleshov, S, Kutovskiy, N, Lachenmaier, T, Landini, C, Leblanc, S, Lebrin, V, Lefevre, F, Lei, R, Leitner, R, Leung, J, Li, D, Li, F, Li, G, Li, H, Li, J, Li, M, Li, N, Li, Q, Li, R, Li, S, Li, T, Li, W, Li, X, Li, Y, Li, Z, Liang, H, Liao, J, Limphirat, A, Lin, G, Lin, S, Lin, T, Ling, J, Ling, X, Lippi, I, Liu, C, Liu, F, Liu, H, Liu, J, Liu, M, Liu, Q, Liu, R, Liu, S, Liu, X, Liu, Y, Liu, Z, Lokhov, A, Lombardi, P, Lombardo, C, Loo, K, Lu, C, Lu, H, Lu, J, Lu, P, Lu, S, Lubsandorzhiev, B, Lubsandorzhiev, S, Ludhova, L, Lukanov, A, Luo, D, Luo, F, Luo, G, Luo, J, Luo, S, Luo, W, Luo, X, Lyashuk, V, Ma, B, Ma, Q, Ma, S, Ma, X, Maalmi, J, Magoni, M, Mai, J, Malyshkin, Y, Mandujano, R, Mantovani, F, Mao, X, Mao, Y, Mari, S, Marini, F, Martini, A, Mayer, M, Mayilyan, D, Mednieks, I, Meng, Y, Meraviglia, A, Meregaglia, A, Meroni, E, Meyhofer, D, Miramonti, L, Mohan, N, Montini, P, Montuschi, M, Muller, A, Nastasi, M, Naumov, D, Naumova, E, Navas-Nicolas, D, Nemchenok, I, Thi, M, Nikolaev, A, Ning, F, Ning, Z, Nunokawa, H, Oberauer, L, Ochoa-Ricoux, J, Olshevskiy, A, Orestano, D, Ortica, F, Othegraven, R, Paoloni, A, Parmeggiano, S, Pei, Y, Pelicci, L, Peng, A, Peng, H, Peng, Y, Peng, Z, Perrot, F, Petitjean, P, Petrucci, F, Pilarczyk, O, Rico, L, Popov, A, Poussot, P, Previtali, E, Qi, F, Qi, M, Qi, X, Qian, S, Qian, X, Qian, Z, Qiao, H, Qin, Z, Qiu, S, Ranucci, G, Rasheed, R, Re, A, Rebii, A, Redchuk, M, Ren, B, Ren, J, Ricci, B, Rifai, M, Roche, M, Rodphai, N, Romani, A, Roskovec, B, Ruan, X, Rybnikov, A, Sadovsky, A, Saggese, P, Sandanayake, D, Sanfilippo, S, Sangka, A, Sawangwit, U, Schever, M, Schwab, C, Schweizer, K, Selyunin, A, Serafini, A, Settimo, M, Sharov, V, Shaydurova, A, Shi, J, Shi, Y, Shutov, V, Sidorenkov, A, Simkovic, F, Singhal, A, Sirignano, C, Siripak, J, Sisti, M, Smirnov, M, Smirnov, O, Sogo-Bezerra, T, Sokolov, S, Songwadhana, J, Soonthornthum, B, Sotnikov, A, Sramek, O, Sreethawong, W, Stahl, A, Stanco, L, Stankevich, K, Steiger, H, Steinmann, J, Sterr, T, Stock, M, Strati, V, Studenikin, A, Su, J, Sun, S, Sun, X, Sun, Y, Sun, Z, Suwonjandee, N, Szelezniak, M, Takenaka, A, Tang, J, Tang, Q, Tang, X, Hariharan, V, Theisen, E, Tietzsch, A, Tkachev, I, Tmej, T, Torri, M, Tortorici, F, Treskov, K, Triossi, A, Triozzi, R, Trzaska, W, Tung, Y, Tuve, C, Ushakov, N, Vedin, V, Verde, G, Vialkov, M, Viaud, B, Vollbrecht, C, von Sturm, K, Vorobel, V, Voronin, D, Votano, L, Walker, P, Wang, C, Wang, E, Wang, G, Wang, J, Wang, L, Wang, M, Wang, R, Wang, S, Wang, W, Wang, X, Wang, Y, Wang, Z, Watcharangkool, A, Wei, W, Wei, Y, Wen, K, Wen, L, Weng, J, Wiebusch, C, Wirth, R, Wonsak, B, Wu, D, Wu, Q, Wu, Y, Wu, Z, Wurm, M, Wurtz, J, Wysotzki, C, Xi, Y, Xia, D, Xiao, X, Xie, X, Xie, Y, Xie, Z, Xin, Z, Xing, Z, Xu, B, Xu, C, Xu, D, Xu, F, Xu, H, Xu, J, Xu, M, Xu, Y, Yan, B, Yan, Q, Yan, T, Yan, X, Yan, Y, Yang, C, Yang, J, Yang, L, Yang, X, Yang, Y, Yao, H, Ye, J, Ye, M, Ye, Z, Yermia, F, You, Z, Yu, B, Yu, C, Yu, G, Yu, H, Yu, M, Yu, X, Yu, Z, Yuan, C, Yuan, Y, Yuan, Z, Yue, B, Zafar, N, Zavadskyi, V, Zeng, S, Zeng, T, Zeng, Y, Zhan, L, Zhang, A, Zhang, B, Zhang, F, Zhang, H, Zhang, J, Zhang, M, Zhang, P, Zhang, Q, Zhang, S, Zhang, T, Zhang, X, Zhang, Y, Zhang, Z, Zhao, J, Zhao, R, Zhao, S, Zheng, D, Zheng, H, Zheng, Y, Zhong, W, Zhou, J, Zhou, L, Zhou, N, Zhou, S, Zhou, T, Zhou, X, Zhu, J, Zhu, K, Zhu, Z, Zhuang, B, Zhuang, H, Zong, L, Zou, J, Zufle, J, Zwickel, S, Abusleme A., Adam T., Ahmad S., Ahmed R., Aiello S., Akram M., Aleem A., Alexandros T., An F., An Q., Andronico G., Anfimov N., Antonelli V., Antoshkina T., Asavapibhop B., de Andre J. P. A. M., Auguste D., Bai W., Balashov N., Baldini W., Barresi A., Basilico D., Baussan E., Bellato M., Beretta M., Bergnoli A., Bick D., Bieger L., Biktemerova S., Birkenfeld T., Blum D., Blyth S., Bolshakova A., Bongrand M., Bordereau C., Breton D., Brigatti A., Brugnera R., Bruno R., Budano A., Busto J., Cabrera A., Caccianiga B., Cai H., Cai X., Cai Y., Cai Z., Callier S., Cammi A., Campeny A., Cao C., Cao G., Cao J., Caruso R., Cerna C., Cerrone V., Chan C., Chang J., Chang Y., Chen C., Chen G., Chen P., Chen S., Chen Y., Chen Z., Cheng J., Cheng Y., Cheng Y. C., Chepurnov A., Chetverikov A., Chiesa D., Chimenti P., Chu Z., Chukanov A., Claverie G., Clementi C., Clerbaux B., Molla M. C., Di Lorenzo S. C., Coppi A., Corti D., Csakli S., Dal Corso F., Dalager O., Datta J., De La Taille C., Deng Z., Depnering W., Ding X., Ding Y., Dirgantara B., Dittrich C., Dmitrievsky S., Dohnal T., Dolzhikov D., Donchenko G., Dong J., Doroshkevich E., Dou W., Dracos M., Druillole F., Du R., Du S., Dugas K., Dusini S., Duyang H., Eck J., Enqvist T., Fabbri A., Fahrendholz U., Fan L., Fang J., Fang W., Fargetta M., Fedoseev D., Fei Z., Feng L. -C., Feng Q., Ferraro F., Fournier A., Gan H., Gao F., Garfagnini A., Gavrikov A., Giammarchi M., Giudice N., Gonchar M., Gong G., Gong H., Gornushkin Y., Gottel A., Grassi M., Gromov M., Gromov V., Gu M., Gu X., Gu Y., Guan M., Guan Y., Guardone N., Guo C., Guo W., Guo X., Hagner C., Han R., Han Y., He M., He W., Heinz T., Hellmuth P., Heng Y., Herrera R., Hor Y., Hou S., Hsiung Y., Hu B. -Z., Hu H., Hu J., Hu S., Hu T., Hu Y., Hu Z., Huang G., Huang H., Huang J., Huang K., Huang W., Huang X., Huang Y., Hui J., Huo L., Huo W., Huss C., Hussain S., Imbert L., Ioannisian A., Isocrate R., Jelmini B., Jeria I., Ji X., Jia H., Jia J., Jian S., Jiang C., Jiang D., Jiang W., Jiang X., Jing X., Jollet C., Kampmann P., Kang L., Karaparambil R., Kazarian N., Khan A., Khatun A., Khosonthongkee K., Korablev D., Kouzakov K., Krasnoperov A., Kuleshov S., Kutovskiy N., Lachenmaier T., Landini C., Leblanc S., Lebrin V., Lefevre F., Lei R., Leitner R., Leung J., Li D., Li F., Li G., Li H., Li J., Li M., Li N., Li Q., Li R., Li S., Li T., Li W., Li X., Li Y., Li Z., Liang H., Liao J., Limphirat A., Lin G. -L., Lin S., Lin T., Ling J., Ling X., Lippi I., Liu C., Liu F., Liu H., Liu J., Liu M., Liu Q., Liu R., Liu S., Liu X., Liu Y., Liu Z., Lokhov A., Lombardi P., Lombardo C., Loo K., Lu C., Lu H., Lu J., Lu P., Lu S., Lubsandorzhiev B., Lubsandorzhiev S., Ludhova L., Lukanov A., Luo D., Luo F., Luo G., Luo J., Luo S., Luo W., Luo X., Lyashuk V., Ma B., Ma Q., Ma S., Ma X., Maalmi J., Magoni M., Mai J., Malyshkin Y., Mandujano R. C., Mantovani F., Mao X., Mao Y., Mari S. M., Marini F., Martini A., Mayer M., Mayilyan D., Mednieks I., Meng Y., Meraviglia A., Meregaglia A., Meroni E., Meyhofer D., Miramonti L., Mohan N., Montini P., Montuschi M., Muller A., Nastasi M., Naumov D. V., Naumova E., Navas-Nicolas D., Nemchenok I., Thi M. T. N., Nikolaev A., Ning F., Ning Z., Nunokawa H., Oberauer L., Ochoa-Ricoux J. P., Olshevskiy A., Orestano D., Ortica F., Othegraven R., Paoloni A., Parmeggiano S., Pei Y., Pelicci L., Peng A., Peng H., Peng Y., Peng Z., Perrot F., Petitjean P. -A., Petrucci F., Pilarczyk O., Rico L. F. P., Popov A., Poussot P., Previtali E., Qi F., Qi M., Qi X., Qian S., Qian X., Qian Z., Qiao H., Qin Z., Qiu S., Ranucci G., Rasheed R., Re A., Rebii A., Redchuk M., Ren B., Ren J., Ricci B., Rifai M., Roche M., Rodphai N., Romani A., Roskovec B., Ruan X., Rybnikov A., Sadovsky A., Saggese P., Sandanayake D., Sanfilippo S., Sangka A., Sawangwit U., Schever M., Schwab C., Schweizer K., Selyunin A., Serafini A., Settimo M., Sharov V., Shaydurova A., Shi J., Shi Y., Shutov V., Sidorenkov A., Simkovic F., Singhal A., Sirignano C., Siripak J., Sisti M., Smirnov M., Smirnov O., Sogo-Bezerra T., Sokolov S., Songwadhana J., Soonthornthum B., Sotnikov A., Sramek O., Sreethawong W., Stahl A., Stanco L., Stankevich K., Steiger H., Steinmann J., Sterr T., Stock M. R., Strati V., Studenikin A., Su J., Sun S., Sun X., Sun Y., Sun Z., Suwonjandee N., Szelezniak M., Takenaka A., Tang J., Tang Q., Tang X., Hariharan V. T., Theisen E., Tietzsch A., Tkachev I., Tmej T., Torri M. D. C., Tortorici F., Treskov K., Triossi A., Triozzi R., Trzaska W., Tung Y. -C., Tuve C., Ushakov N., Vedin V., Verde G., Vialkov M., Viaud B., Vollbrecht C. M., von Sturm K., Vorobel V., Voronin D., Votano L., Walker P., Wang C., Wang C. -H., Wang E., Wang G., Wang J., Wang L., Wang M., Wang R., Wang S., Wang W., Wang X., Wang Y., Wang Z., Watcharangkool A., Wei W., Wei Y., Wen K., Wen L., Weng J., Wiebusch C., Wirth R., Wonsak B., Wu D., Wu Q., Wu Y., Wu Z., Wurm M., Wurtz J., Wysotzki C., Xi Y., Xia D., Xiao X., Xie X., Xie Y., Xie Z., Xin Z., Xing Z., Xu B., Xu C., Xu D., Xu F., Xu H., Xu J., Xu M., Xu Y., Yan B., Yan Q., Yan T., Yan X., Yan Y., Yang C., Yang J., Yang L., Yang X., Yang Y., Yao H., Ye J., Ye M., Ye Z., Yermia F., You Z., Yu B., Yu C., Yu G., Yu H., Yu M., Yu X., Yu Z., Yuan C., Yuan Y., Yuan Z., Yue B., Zafar N., Zavadskyi V., Zeng S., Zeng T., Zeng Y., Zhan L., Zhang A., Zhang B., Zhang F., Zhang H., Zhang J., Zhang M., Zhang P., Zhang Q., Zhang S., Zhang T., Zhang X., Zhang Y., Zhang Z., Zhao J., Zhao R., Zhao S., Zheng D., Zheng H., Zheng Y., Zhong W., Zhou J., Zhou L., Zhou N., Zhou S., Zhou T., Zhou X., Zhu J., Zhu K., Zhu Z., Zhuang B., Zhuang H., Zong L., Zou J., Zufle J., Zwickel S., Abusleme, A, Adam, T, Ahmad, S, Ahmed, R, Aiello, S, Akram, M, Aleem, A, Alexandros, T, An, F, An, Q, Andronico, G, Anfimov, N, Antonelli, V, Antoshkina, T, Asavapibhop, B, de Andre, J, Auguste, D, Bai, W, Balashov, N, Baldini, W, Barresi, A, Basilico, D, Baussan, E, Bellato, M, Beretta, M, Bergnoli, A, Bick, D, Bieger, L, Biktemerova, S, Birkenfeld, T, Blum, D, Blyth, S, Bolshakova, A, Bongrand, M, Bordereau, C, Breton, D, Brigatti, A, Brugnera, R, Bruno, R, Budano, A, Busto, J, Cabrera, A, Caccianiga, B, Cai, H, Cai, X, Cai, Y, Cai, Z, Callier, S, Cammi, A, Campeny, A, Cao, C, Cao, G, Cao, J, Caruso, R, Cerna, C, Cerrone, V, Chan, C, Chang, J, Chang, Y, Chen, C, Chen, G, Chen, P, Chen, S, Chen, Y, Chen, Z, Cheng, J, Cheng, Y, Chepurnov, A, Chetverikov, A, Chiesa, D, Chimenti, P, Chu, Z, Chukanov, A, Claverie, G, Clementi, C, Clerbaux, B, Molla, M, Di Lorenzo, S, Coppi, A, Corti, D, Csakli, S, Dal Corso, F, Dalager, O, Datta, J, De La Taille, C, Deng, Z, Depnering, W, Ding, X, Ding, Y, Dirgantara, B, Dittrich, C, Dmitrievsky, S, Dohnal, T, Dolzhikov, D, Donchenko, G, Dong, J, Doroshkevich, E, Dou, W, Dracos, M, Druillole, F, Du, R, Du, S, Dugas, K, Dusini, S, Duyang, H, Eck, J, Enqvist, T, Fabbri, A, Fahrendholz, U, Fan, L, Fang, J, Fang, W, Fargetta, M, Fedoseev, D, Fei, Z, Feng, L, Feng, Q, Ferraro, F, Fournier, A, Gan, H, Gao, F, Garfagnini, A, Gavrikov, A, Giammarchi, M, Giudice, N, Gonchar, M, Gong, G, Gong, H, Gornushkin, Y, Gottel, A, Grassi, M, Gromov, M, Gromov, V, Gu, M, Gu, X, Gu, Y, Guan, M, Guan, Y, Guardone, N, Guo, C, Guo, W, Guo, X, Hagner, C, Han, R, Han, Y, He, M, He, W, Heinz, T, Hellmuth, P, Heng, Y, Herrera, R, Hor, Y, Hou, S, Hsiung, Y, Hu, B, Hu, H, Hu, J, Hu, S, Hu, T, Hu, Y, Hu, Z, Huang, G, Huang, H, Huang, J, Huang, K, Huang, W, Huang, X, Huang, Y, Hui, J, Huo, L, Huo, W, Huss, C, Hussain, S, Imbert, L, Ioannisian, A, Isocrate, R, Jelmini, B, Jeria, I, Ji, X, 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Abstract

The Jiangmen Underground Neutrino Observatory (JUNO), the first multi-kton liquid scintillator detector, which is under construction in China, will have a unique potential to perform a real-time measurement of solar neutrinos well below the few MeV threshold typical of Water Cherenkov detectors. JUNO’s large target mass and excellent energy resolution are prerequisites for reaching unprecedented levels of precision. In this paper, we provide estimation of the JUNO sensitivity to 7Be, pep, and CNO solar neutrinos that can be obtained via a spectral analysis above the 0.45 MeV threshold. This study is performed assuming different scenarios of the liquid scintillator radiopurity, ranging from the most optimistic one corresponding to the radiopurity levels obtained by the Borexino experiment, up to the minimum requirements needed to perform the neutrino mass ordering determination with reactor antineutrinos — the main goal of JUNO. Our study shows that in most scenarios, JUNO will be able to improve the current best measurements on 7Be, pep, and CNO solar neutrino fluxes. We also perform a study on the JUNO capability to detect periodical time variations in the solar neutrino flux, such as the day-night modulation induced by neutrino flavor regeneration in Earth, and the modulations induced by temperature changes driven by helioseismic waves.

Published
2023

39. Safety and efficacy of intraperitoneal drain placement after emergency colorectal surgery: An international, prospective cohort study

Author

Sgro, A, Blanco-Colino, R, Ahmed, W, Brindl, N, Gujjuri, R, Lapolla, P, Mills, E, Perez-Ajates, S, Soares, A, Varghese, C, Xu, W, Mclean, K, Chapman, S, Espin-Basany, E, Glasbey, J, Mihaljevic, A, Nepogodiev, D, Pata, F, Pellino, G, Pockney, P, Dudi-Venkata, N, Egoroff, N, Ludbrook, I, Raubenheimer, K, Richards, T, Delibegovic, S, Salibasic, M, Amjad, T, Dorr-Harim, C, Gedeon, N, Gsenger, J, Tachezy, M, Bini, S, Gallo, G, Gori, A, Picciariello, A, Podda, M, Riboni, C, Machatschek, M, Nguyen, A, Jakubauskas, M, Kryzauskas, M, Poskus, T, Kuiper, S, Wang, J, Wells, C, Bissett, I, Augestad, K, Steinholt, I, Vieira, B, Juloski, J, Anabitarte Bautista, O, Kasmy El Kasmy, Y, Martin-Borregon, P, Ossola Revilla, M, Van Straten, S, Aktas, M, Baki, B, Akhbari, M, Baker, D, Bhatia, S, Brown, S, Cambridge, W, Kamarajah, S, Khaw, R, Kouli, O, Murray, V, Trout, I, Yasin, I, Wong, J, Reyhani, H, Wong, K, Pancharatnam, R, Chia, W, Walmsley, A, Hassane, A, Saeed, D, Wang, B, Walters, B, Nowinka, Z, Alsaif, A, Mirza, M, Foster, K, Luu, J, Kakodkar, P, Hughes, J, Yogarajah, T, Antypas, A, Rahman, A, Bradbury, M, Mclarnon, M, Nagi, S, Riad, A, Erotocritou, M, Kyriacou, H, Kaminskaite, V, Alfadhel, S, Fatimah Hussain, Q, Handa, A, Massy-Westropp, C, Custovic, S, Dimov, R, Mughal, H, Slavchev, M, Ivanov, T, Gouvas, N, Hegazi, A, Kocian, P, Kjaer, M, Mark-Christensen, A, Papakonstantinou, D, Machairas, N, Triantafyllou, T, Garoufalia, Z, Korkolis, D, Castaldi, A, Giaccari, S, Spolverato, G, Pagano, G, Milone, M, Turri, G, Colombo, F, Cucinotta, E, Poillucci, G, Perra, T, Tutino, R, Belia, F, Coletta, D, Belli, A, Rega, D, Cianci, P, Pirozzolo, G, Di Lena, M, Perrone, F, Giani, A, Lovisetto, F, Grassia, M, Pipitone Federico, N, Ferrara, F, Biancafarina, A, Tamini, N, Sinibaldi, G, Tuminello, F, Galleano, R, Sasia, D, Bragaglia, L, de Manzoni Garberini, A, Pesce, A, Cassaro, F, Venturelli, P, Canu, G, Esposito, G, Campanelli, M, Cardia, R, Ricciardiello, M, Sagnotta, A, Canonico, G, De 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H., Chohan N., Thaker A., Thompson B., Ahari D., Burdekin E., Okwu U., Akintunde A., Lhaf F., Douthwaite J., Govindan R., Leelamanthep S., Gull E., Wright F., Dundas L., Mackdermott N., Burchi-Khairy T., Campbell I., Walsh J., Yeo J. Y., Meehan S., Banerjee D., Fu M., Kawka M., Ali T., Hussain Z., Thomas C., Ahmad H., Moroney J., Yick C., Risquet R., Ntuiabane D., Shimato M., Khan M., Ilangovan S., Vaselli N. M., Smithers R., Uhanowita Marage R., Valnarov-Boulter A., Kayran J., Banerjee M., Parekh-Hill N., Hooper A., Bowen J., Jagdish R., Mcquoid C., Khan N., O Hare R., Jeffery S., Zahid A., Elsworth C., Walter L., Dhillon S., Rao S., Anthony A., Ashaye A., Phillips N., Faderani R., Pengelly S., Choi S., Kwak S. Y., Lau Y. H. L., Bagheri K., Ong D. Y. C., Kerr E., Falconer K., Clancy N., Douglas S., Zhang Y., Greenfield F., Mutanga I., McAlinden J., Willis L., Adefolaju A., Agarwal H., Barter R., Harris G., Spencer G., Lee M. 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A., Kurtenkov M., Jovanovic M., Vician M., Egea Arias P., Beltran de Heredia J., Labalde Martinez M., De Santiago Alvarez I., Alvarez-Gallego M., Rodriguez Artigas J. M., Dwidar O., Korkmaz H. K., Eray I. C., Meric S., Aydin R., Cetin B., Karaca B. E., Kuyumcu O. F., Yuksel E., Uprak T. K., Karabulut K., Kavukcu E., Mansor A., Hackett R., Zammit-Maempel M., Sabaratnam R., Maan A., Ferarrio I., Dixon L., Halai H., Sethi S., Nelson L., Grassam-rowe A., Krishnan E., Deeny D., McKeever M., George Pandeth A., Dhavala P., Sreenivasan S., Sundaram Venkatesan G., Zhu L., Atiyah Z., Gregory J., Morey T., Seymour Z., Holdsworth L., Abdelmahmoud S., Bourhill J., Bisheet G., Shaw J., Kulkarni K., Kumarakulasingam P., Pillay S., Al-Habsi R., Kungwengwe G., Richards J., Davoudi K., Ibrahim B., Tailor B., Zayed M., Chen F., Bailey S., Sheefat S., Nawaz G., Pawar R., Marsh S., Sam Z. H., Roy Bentley S., Simpson C., Hughes J., Lim Y., Ooi R., Toh W. H., Mannion P., Lovett A., Kincius A., Hussein S., Kirby E., Beckett R. G., Salmon J., Glynn T., Choo S. Y., Lyons S., Browne D., Ravindran W., Ahmad S., Zhu X., McNulty J., McCarthy L., Ng J., Karmally Z., McTeir K., Hanna M., Tan E., Namdeo S., Schembri R., and Pusey E.

Abstract

Aim: Intraperitoneal drains are often placed during emergency colorectal surgery. However, there is a lack of evidence supporting their use. This study aimed to describe the efficacy and safety of intraperitoneal drain placement after emergency colorectal surgery. Method: COMPlicAted intra-abdominal collectionS after colorectal Surgery (COMPASS) is a prospective, international, cohort study into which consecutive adult patients undergoing emergency colorectal surgery were enrolled (from 3 February 2020 to 8 March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included rate and time-to-diagnosis of postoperative intraperitoneal collections, rate of surgical site infections (SSIs), time to discharge and 30-day major postoperative complications (Clavien–Dindo III–V). Multivariable logistic and Cox proportional hazards regressions were used to estimate the independent association of the outcomes with drain placement. Results: Some 725 patients (median age 68.0 years; 349 [48.1%] women) from 22 countries were included. The drain insertion rate was 53.7% (389 patients). Following multivariable adjustment, drains were not significantly associated with reduced rates (odds ratio [OR] = 1.56, 95% CI: 0.48–5.02, p = 0.457) or earlier detection (hazard ratio [HR] = 1.07, 95% CI: 0.61–1.90, p = 0.805) of collections. Drains were not significantly associated with worse major postoperative complications (OR = 1.26, 95% CI: 0.67–2.36, p = 0.478), delayed hospital discharge (HR = 1.11, 95% CI: 0.91–1.36, p = 0.303) or increased risk of SSIs (OR = 1.61, 95% CI: 0.87–2.99, p = 0.128). Conclusion: This is the first study investigating placement of intraperitoneal drains following emergency colorectal surgery. The safety and clinical benefit of drains remain uncertain. Equipoise exists for randomized trials to define the safety and efficacy of drains in emergency colorectal surgery.

Published
2023

43. Juvenile Female Rats, but Not Male Rats, Show Renewal, Reinstatement, and Spontaneous Recovery Following Extinction of Conditioned Fear

Author

Park, Chun Hui J., Ganella, Despina E., and Kim, Jee Hyun

Abstract

Anxiety disorders emerge early, and girls are significantly more likely to develop anxiety compared to boys. However, sex differences in fear during development are poorly understood. Therefore, we investigated juvenile male and female rats in the relapse behaviors following extinction of conditioned fear. In all experiments, 18-d-old rats first received three white-noise-footshock pairings on day 1. On day 2, extinction involved 60 white-noise alone trials. In experiment 1, we examined renewal by testing the rats in either the same or different context as extinction on day 3. Male rats did not show renewal, however, female rats showed renewal. Experiment 2 investigated reinstatement by giving rats either a mild reminder footshock or context exposure on day 3. When tested the next day, male rats did not show reinstatement, whereas female rats showed reinstatement. Experiment 3 investigated spontaneous recovery by testing the rats either 1 or 5 d following extinction. Male rats did not show any spontaneous recovery whereas female rats did. Taken together, fear regulation appear to be different in males versus females from early in development, which may explain why girls are more prone to suffer from anxiety disorders compared to boys.

Published
2017
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44. Genome-wide association analysis identifies six new loci associated with forced vital capacity

Author

Loth, DW, Artigas, MS, Gharib, SA, Wain, LV, Franceschini, N, Koch, B, Pottinger, TD, Smith, AV, Duan, Q, Oldmeadow, C, Lee, MK, Strachan, DP, James, AL, Huffman, JE, Vitart, V, Ramasamy, A, Wareham, NJ, Kaprio, J, Wang, XQ, Trochet, H, Kähönen, M, Flexeder, C, Albrecht, E, Lopez, LM, De Jong, K, Thyagarajan, B, Alves, AC, Enroth, S, Omenaas, E, Joshi, PK, Fall, T, Viñuela, A, Launer, LJ, Loehr, LR, Fornage, M, Li, G, Wilk, JB, Tang, W, Manichaikul, A, Lahousse, L, Harris, TB, North, KE, Rudnicka, AR, Hui, J, Gu, X, Lumley, T, Wright, AF, Hastie, ND, Campbell, S, Kumar, R, Pin, I, Scott, RA, Pietiläinen, KH, Surakka, I, Liu, Y, Holliday, EG, Schulz, H, Heinrich, J, Davies, G, Vonk, JM, Wojczynski, M, Pouta, A, Johansson, A, Wild, SH, Ingelsson, E, Rivadeneira, F, Völzke, H, Hysi, PG, Eiriksdottir, G, Morrison, AC, Rotter, JI, Gao, W, Postma, DS, White, WB, Rich, SS, Hofman, A, Aspelund, T, Couper, D, Smith, LJ, Psaty, BM, Lohman, K, Burchard, EG, Uitterlinden, AG, Garcia, M, Joubert, BR, McArdle, WL, Musk, AB, Hansel, N, Heckbert, SR, Zgaga, L, Van Meurs, JBJ, Navarro, P, Rudan, I, Oh, YM, Redline, S, Jarvis, DL, Zhao, JH, Rantanen, T, O'Connor, GT, and Ripatti, S

Subjects
Developmental Biology, Medical and Health Sciences, Biological Sciences
Abstract

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10-8) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.© 2014 Nature America, Inc. All rights reserved.

Published
2014

49. Ritual concepts and political factors in the making of Tang Dynasty princess tombs (643-706 A.D.)

Author

Liu, Chao-Hui J.

Subjects
394.1095109021
Abstract

The thesis examines the art and epitaphs of five princess tombs of the Chinese medieval Tang Dynasty (618-907 A.D.) against the background of the historical period and ritual concepts. The thesis discovers that the tomb of a princess did not depict her former life but that its scale, epitaph, and art reflected the status that the tomb builders planned for the deceased, the current political situation, and contemporary concepts of death and burial. Ritual is the grammar with which image and text built their representation of the princess's last abode. The first chapter provides a survey of the field, theoretical perspective and research methodology, and a broad narrative account of the five tombs using archaeological reports and firsthand fieldwork observation. Chapter Two explores the historical background of the sixty-four year period (643-706 A.D.) in which these tombs were built, the conflicts over the extent of princess influence and prestige and the relationship between status and representation. Chapter Three uses ritual texts to reconstruct the possible structure of the transition of the princesses from life to death and the codification of their commemoration, beginning from the living household of the princess and ending at the tomb, her new abode-in-death. The preparations and the burial itself could take anywhere from one to seven months. I argue that these ritual actions and concepts created a space in which the classic stages of rites of passage-separation, liminality, and re-incorporation-occur. Chapter Four shows how princess identities were codified at death by epitaphs which followed a ritually- prescribed plan in describing the princesses' lives. Chapter Five discusses how murals, pottery figurines, and the line engravings on stone together contribute to a coherent program depicting the entry and settlement of the deceased into her new home.

Published
2005
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50. IncobotulinumtoxinA injections at intervals <10 weeks are effective and safe for cervical dystonia patients with inadequate benefit from standard intervals

Author

Comella, C., primary, Hauser, R., additional, Isaacson, S., additional, Truong, D., additional, Oguh, O., additional, Hui, J., additional, Molho, E., additional, Brodsky, M., additional, Furr-Stimming, E., additional, Comes, G., additional, Hast, M., additional, and Charles, D., additional

Published
2023
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