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Climate change in the semi-arid northern Kenya is evidenced by increasing frequency and duration of severe droughts. The effects are devastating with the region experiencing massive loss of livestock, total crop failures and increased levels of hunger and starvation resulting in near collapse of livelihood sources which is mainly pastoralism. This study investigated the most appropriate drought adaptive strategies that pastoralists in the semi-arid northern Kenya depend on to subsist. Data was collected from the counties of Garissa, Samburu, Turkana, Isiolo, Marsabit, West Pokot, Laikipia and Baringo where drought is persistent. The study used a cross-sectional design where past and current data was obtained through face-to-face and telephone interviews from purposively sampled respondents and observations. Document information collected supplemented the information obtained from the respondents. The pastoralists embrace adaptive strategies that are easy, accessible and affordable. The traditional adaptive strategies such as food preservation and herd composition and management predominate. These strategies are preferred because of their ease of implementation and also culturally acceptable. With increasing drought severity and other factors like increase in population growth, there has been decline in grazing areas limiting transhumance activities. This has stemmed the adoption of non-pastoral activities such as crop farming, craftwork, poultry keeping, petty trade and dependence on external assistance. The traditional adaptive strategies play a key role in surviving the droughts. Due to their pastoral nature, the non-pastoral sedentary practices do not fit their lifestyles and are less practiced especially by men but taken up much better by women who are left at home. Therefore, efforts to enhance pastoral resilience in the semi-arid areas should strengthen the traditional practices as well as capacity building on the non-pastoral activities.

Colombia depende de la importación de medicamentos, así como de gran parte de los materiales (principios activos y excipientes) requeridos para su elaboración; problemática que genera consecuencias sanitarias y macroeconómicas, las cuales se agudizan en el contexto de desindustrialización nacional y de disrupción tecnológica. De esta manera, se acepta que la disponibilidad y acceso a medicamentos y otras tecnologías sanitarias esenciales son un requisito fundamental para alcanzar la autonomía sanitaria de un país. Por lo tanto, resulta imprescindible coordinar esfuerzos entre diversos sectores sociales para desarrollar una agenda pública enfocada a la creación de condiciones que fortalezcan las capacidades científicas y tecnológicas de la industria farmacéutica local, y con ello, mejorar el suministro farmacéutico del país. En el presente documento se presentan conceptos teóricos y prácticos que deberían ser considerados en la definición y materialización de una política pública encaminada a fortalecer la industria farmacéutica y favorecer la autonomía sanitaria de Colombia.

Kenya is rapidly urbanizing at an annual rate of about 4.3%. One of the consequences of urbanization has been the problem of food insecurity in peri-urban areas. Increased migration to urban from rural areas has enhanced food insecurity in these areas. The peri-urban area of Kangundo-Tala in Machakos County is one of the fastest-growing peri-urban areas due to its proximity to the capital city of Nairobi. This study investigated the impact of home gardening in enhancing food security in the rapidly urbanizing middle-income Kangundo–Tala peri-urban areas of Machakos County, Kenya. The specific objectives of the study were: to identify the causes of households’ food insecurity in the study area; to examine the factors influencing the adoption of home gardening and; to establish the role of home gardening as a measure of households’ food security. To measure food security, three consumption behaviors were analyzed: consumption changes, food expenditure reduction and income expansion. A qualitative approach was adopted where a total of 120 newly settled households were interviewed. The three main causes of food insecurity were identified (i) small land sizes, (ii) low and erratic rainfall and, (iii) the socialization of peri-urban dwellers. About 68% of the households were practicing at least one form of home gardening. The need for safe and nutritious food, seasonal unavailability, and inaccessibility of food encouraged the establishment of home gardens. From the gardens, households were able to diversify their diets, access safe food and have food readily available. With enhanced stability in food availability, accessibility, and utilization, the study concluded that home gardens played a major role in enhancing food. However, the production was at a very small scale. Up-scaling of home gardening by the Ministry of Agriculture through training was recommended.

Location of markets determine how producers and consumers interact temporally and spatially. In arid and semi-arid lands this is of significant importance because market patronage is largely dictated by availability and the distribution of market facilities. Since close to 67% of population in Kenya live in the most food insecure rural regions often characterised by rain failure and famine, market purchase of food comprise main source of food and nutrition needs for communities living here. To understand how market location and patterns of market use influence food and nutrition security, a case study of Tharaka subcounty was used. Tharaka sub county besides lying in semi-arid region has some of the highest malnutrition rates of 30% compared to the average national rate of 20.9%. To achieve the fore mentioned objective, the study employed mixed method where spatial modelling and statistical analysis was used. Results indicate limited number of households actually used markets for their food and nutrition needs compared to the potential number modeled in the study. It was also discovered that food markets were most used throughout the year compared to livestock markets whose use peaked during the lean months of August and September a period coinciding with food shortage months. Generally, spatial distribution of open-air food and livestock markets as well as geographic isolation of villages from markets influence market patronage in Tharaka subcounty. These observations are closely linked to the perennial problem of food and nutrition insecurity experienced in the area. To reverse the trend, concerted efforts are needed to increase market participation of smallscale livestock and food producers in food distribution and supply chain. Moreover, Initiatives to improve service delivery and build local production capacities for these farmers should be considered.

In semi-arid rural Kenya, most households travel long distances to access food markets. This has negative effects on food consumption and the use of market facilities. Over70 % of farmers in Tharaka Constituency lack access to formal markets often relying on contracted middlemen who buy at farm gate for traders in major urban centres. Studies on intra-variation in accessibility to market services remains scanty, yet market purchases account for most food consumed across urban and rural areas. Distance defines accessibility and performance of market facilities in most areas where food insecurity and malnutrition are common. This study used Geographic Information Systems (GIS) to measure physical accessibility to open air markets within semi-arid Tharaka, a constituency where vulnerability to acute food shortage is comparatively high. Normative, administrative and geospatial datasets were used in the analysis. Results showed that geographic accessibility to local market centres vary spatially across the villages. In terms of market accessibility, 40.4% of the total population live in areas with high inaccessibility risks while 36.1% are found in places with low inaccessibility risks and only 23.5% of the population exists in areas with moderate inaccessibility risks. This means a large proportion of deprived population live in villages within high to very high inaccessibility risk areas. This spatial inequity has implications on household food security and explains the chronic problems of hunger and malnutrition experienced in the area. Therefore, markets within high inaccessibility risk areas should be upgraded and infrastructure thereof improved to enable food mobility across these areas.

Food waste occurs when food is ready for consumption but not consumed. Food waste has considerable social, economic and environmental impacts. Even though it has become a global concern, no comprehensive studies on food waste in Kenya is available. This study sought to establish the sociodemographic determinants of households’ food waste in Garissa sub-county, in Garissa County, Kenya. A total of 165 consumers were involved in the study. Bakery products were the most wasted. The per capita food wasted was 6.1 kg/person/year or approximately 5.1 tonnes (equivalent to 39,352,110 Kcal) for Garissa County. At a per capita consumption of 2360 Kcal/ person/day, the food wasted was enough to feed 16,674 people for one day. Males were more wasteful than females. Food waste was higher in households: headed by people aged 25 – 34 years; with higher income; with urban residency and with large sizes. Annually, Kshs 9600 (US$96) per household was lost from the wasted food translating to a loss of Kshs 1.4 billion (US$ 13.6 million) from the 141,353 households in Garissa County. With guidance and good policies, food waste can be managed since the majority of the consumers were concerned about food waste and had intentions to reduce it.

A 65-year-old male presented to our dermatology clinic with a two-day intensely pruritic rash covering his back. The lesions were predominantly on his chest, upper extremity, and back. He denied any prior history of similar rashes and his past medical history was non-contributory. A detailed exposure history revealed the patient had eaten Shiitake mushrooms for dinner 48 hours previously. Physical examination showed a truncal dominant rash. Close-up examination confirmed the papulovesicular nature of the rash with multiple small vesicles grouped both along the breadth and length of each linear streak on an erythematous background. Biopsies showed spongiosis with micro-vesiculation. Blood work showed a nominal CBC and CRP/ESR and serum IgE. The patient was put on topical steroid and the rash resolved in one week. With increasing mushroom consumption [1], cognizance of this etiology avoids a diagnostic ‘odyssey’ and prevents recurrence of this very characteristic rash.

In semi-arid rural Kenya, most households travel long distances to access food markets. This has negative effects on food consumption and the use of market facilities. Over70 % of farmers in Tharaka Constituency lack access to formal markets often relying on contracted middlemen who buy at farm gate for traders in major urban centres. Studies on intra-variation in accessibility to market services remains scanty, yet market purchases account for most food consumed across urban and rural areas. Distance defines accessibility and performance of market facilities in most areas where food insecurity and malnutrition are common. This study used Geographic Information Systems (GIS) to measure physical accessibility to open air markets within semi-arid Tharaka, a constituency where vulnerability to acute food shortage is comparatively high. Normative, administrative and geospatial datasets were used in the analysis. Results showed that geographic accessibility to local market centres vary spatially across the villages. In terms of market accessibility, 40.4% of the total population live in areas with high inaccessibility risks while 36.1% are found in places with low inaccessibility risks and only 23.5% of the population exists in areas with moderate inaccessibility risks. This means a large proportion of deprived population live in villages within high to very high inaccessibility risk areas. This spatial inequity has implications on household food security and explains the chronic problems of hunger and malnutrition experienced in the area. Therefore, markets within high inaccessibility risk areas should be upgraded and infrastructure thereof improved to enable food mobility across these areas., doi: 10.15414/raae.2020.23.02.36-44; https://roaae.org/issue/review-of-agricultural-and-applied-economics-raae-vol-23-no-2-2020-2/?article=gis-analysis-of-physical-accessibility-to-food-markets-in-tharaka-region-of-kenya

The group ranch system is one of the best land ownership and livestock production strategies in the dry lands of the world where the potential for rain-fed agriculture is limited. Its sustainability relies greately on choice of sustainability strategies adopted by group ranches. Numerous studies on the establishment of group ranches, their dissolution and coping strategies have been conducted but with less focus on the sustainability of the group ranches.This study attempts to fill the gap. It is against this background that this study investigated environmental characteristics influencing choice of sustainability strategies adopted by group ranches in Samburu County, Kenya. The investigation adopted a descriptive survey research design employing use of Questionnaires, Key Informant Interviews, Focus Group Discussions and observation as primary data collection methods.The target population for the study was the 16,611 registered members in 38 group ranches spread out in the County. The study sampled 12 group ranches with approximately 5,643 members from which 374 respondents were systematically sampled. Purposive sampling was used to select Key Informants and the participants in the Focus Group Discussions.The study employed Multi-linear Regression to analyse environmental characteristics determining choice of sustainability strategies. The Analysis of Variance (ANOVA) was used to test the hypothesis and p-value of 0.00 was obtained, indicating that environmental characteristics (rainfall patterns, droughts, temperatures, diseases and floods) significantly influenced choice of sustainability strategies adopted by group ranches in the County. Overall, rainfall patterns were the predominating environmental characteristic with a regression coefficient of 0.317 while diseases had the least influence on choice of sustainability strategies adopted by group ranches in Samburu County, with a regression coefficient of 0.029. The study recommended integration of environmental characteristics in formulating policies for sustainability of group ranches.

The group ranch system is one of the best land ownership and livestock production strategies in the dry lands of the world where the potential for rain-fed agriculture is limited. This has resulted in numerous studies on the establishment of group ranches, their dissolution and coping strategies but with less focus on the sustainability of the group ranches. It is against this background that this study investigated organizational factors influencing choice of sustainability strategies adopted by group ranches in Samburu County; Kenya. The study adopted a descriptive survey research design employing use of Questionnaires, Key Informant Interviews, Focus Group Discussions and observation as primary data collection methods. The study used content validity and Cronbach’s alpha methods to measure validity and reliability of the research instruments, respectively. The target population for the study was the 16,611 registered members in 38 group ranches spread out in the County. The study sampled twelve group ranches with approximately 5,643 members from which 374 respondents were systematically sampled. Purposive sampling was used to select Key Informants and the participants in the Focus Group Discussions. The investigation employed Multi-linear Regression to analyse organizational factors influencing choice of sustainability strategies adopted by group ranches in Samburu County while the Analysis of Variance (ANOVA) was used to test the hypothesis which stated that there was no significant influence of organizational factors on choice of sustainability strategies adopted by group ranches in Samburu County, Kenya. The p-value of 0.00 was obtained, indicating that organizational factors significantly influenced choice of sustainability strategies adopted by group ranches in the County. Overall, past experiences was the predominating organizational factor with a regression coefficient of 0.432 while past strategies had the least influence on choice of sustainability strategies adopted by group ranches in Samburu County, with a regression coefficient of 0.110. The study recommended integration of organizational factors in formulating policies for sustainability of group ranches.

Drought is a major threat to water sources in the world. It causes variation in volumes of water flow. Once compounded with other factors, water scarcity arises. However, perceptions of households on the impact of drought on water sources vary from region to region. Understanding the perceptions of households is critical in ensuring people cope with water shortages. Thus, this paper sought to examine household’s perception on the impact of drought on water resources in Makindu Sub-County, Kenya. The study employed descriptive survey research design. A total of 370 households were sampled using simple random sampling. Purposive sampling was used to select the key informants. Questionnaires and key informants’ interview schedules were used to collect primary data. Data from questionnaires was coded and analyzed using SPSS Version 20. As perceived by the households’ drought led to drying up of water sources and further its impact varied from one drought intensity to another. The study also established that overuse by households, high rates of evaporation and encroachment of people to water sources were also affecting water sources. It was concluded that households should embrace adaptation and coping strategies to minimize water shortages. It is recommended that sensitization is required to equip individuals with knowledge to conserve water sources. The study provides new knowledge that is beneficial for water resource saving policy making, governance as well as for education at community and institutional levels. Keywords: Perceptions, drought, households

The increasing prevalence of high-risk human papillomavirus (HR-HPV)-associated head and neck squamous cell carcinoma (HNSCC) has prompted strong clinical demands for detecting HR-HPV directly in the tumor. Although p16 immunohistochemistry (IHC) has been the standard testing method, it has limitations including false positivity, lack of sensitivity in low tumor cell samples such as fine-needle aspirate (FNA), and its subjectivity. We developed a modified method based on a commercial automated HR-HPV PCR assay and evaluated the performance characteristics and the diagnostic utility of this assay for direct HR-HPV detection in the HNSCC samples. HNSCC formalin-fixed, paraffin-embedded blocks were retrieved from archives including 44 excisions, 63 biopsies, and 16 FNAs. Tissue slices were trimmed from the blocks, deparaffinized, lysed, and loaded on the commercial automated platform for HR-HPV PCR. All specimens had a concurrent p16 IHC performed. The PCR assay showed high concordance with the p16 IHC (96%; 99/103) and excellent positive agreement (91.5%) and negative agreement (100%). In addition, the PCR assay provided more conclusive results in samples with equivocal p16 IHC results. The modified commercial automated HR-HPV PCR test is a labor-efficient, quick, reliable, sensitive, and specific method for detecting HR-HPV in formalin-fixed, paraffin-embedded samples. This assay also showed excellent diagnostic utility in samples with equivocal p16 IHC results, including FNA cell blocks.

Pediatric chronic myelogenous leukemia is uncommon. We report a pediatric patient with chronic myelogenous leukemia presenting with a normal white blood cell count and no circulating immature myeloid cells. The patient presented with extreme thrombocytosis (platelet count range: 2175–3064 × 109/L) noted incidentally. No splenomegaly was found. Examination of the bone marrow aspirate revealed normal cellularity and normal myeloid: erythroid ratio with marked megakaryocytic hyperplasia. Molecular studies on the bone marrow aspirate detected both the major BCR/ABL1 p210 fusion transcript (9280 copies; p210/ ABL1 ratio: 38.2%) and the minor p190 transcript (below limit of quantitation). The platelet count normalized within 2 weeks after treatment with the second-generation tyrosine kinase inhibitor dasatinib. Follow-up after 3 months revealed a 1.87 log reduction in p210 transcripts compared to diagnosis and no detectable p190 transcripts. This case highlights the need to include BCR/ABL1 fusion testing to accurately diagnose pediatric patients presenting with isolated thrombocytosis.

Background \ud \ud Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are highly effective tools for controlling malaria transmission in Africa because the most important vectors, from the Anopheles gambiae complex and the A. funestus group, usually prefer biting humans indoors at night.\ud \ud Methods \ud \ud Matched surveys of mosquito and human behaviour from six rural sites in Burkina Faso, Tanzania, Zambia, and Kenya, with ITN use ranging from 0.2% to 82.5%, were used to calculate the proportion of human exposure to An. gambiae sensu lato and An. funestus s.l. that occurs indoors (πi), as an indicator of the upper limit of personal protection that indoor vector control measures can provide. This quantity was also estimated through use of a simplified binary analysis (πiB) so that the proportions of mosquitoes caught indoors (Pi), and between the first and last hours at which most people are indoors (Pfl) could also be calculated as underlying indicators of feeding by mosquitoes indoors or at night, respectively.\ud \ud Results \ud \ud The vast majority of human exposure to Anopheles bites occurred indoors (πBi = 0.79–1.00). Neither An. gambiae s.l. nor An. funestus s.l. strongly preferred feeding indoors (Pi = 0.40–0.63 and 0.22–0.69, respectively), but they overwhelmingly preferred feeding at times when most humans were indoors (Pfl = 0.78–1.00 and 0.86–1.00, respectively).\ud \ud Conclusions \ud \ud These quantitative summaries of behavioural interactions between humans and mosquitoes constitute a remarkably consistent benchmark with which future observations of vector behaviour can be compared. Longitudinal monitoring of these quantities is vital to evaluate the effectiveness of ITNs and IRS and the need for complementary measures that target vectors outdoors.

Kenya is an agri-based economy that heavily relies on rainfall performance. Unfortunately, changes in rainfall patterns have threatened the agricultural sector since it is largely rain-fed. The frequent occurrence and increased severity of climatic extremes, particularly droughts and floods, have led to slow economic development in the affected areas. However, the impacts on the economy vary from one hydrometeorological disaster to the other depending on their characteristics. From the case studies of Laikipia and Bunyala sub- counties in Kenya, the study established an increasing trend in both the frequency and magnitude of floods and droughts. Prolonged and severe flood and drought events had adverse impacts on economic development through (a) decrease in agricultural production, (b) poor prices for livestock and agricultural produce and (c) destruction of the immediate environment which in turn exacerbate the impacts. An inverse relationship between economic development and the magnitude of the disaster was established. The consequence have been increased poverty levels in the areas due to slow economic development.

Hyaluronic acid nanogel (HyA-AT) is a redox sensitive crosslinkable nanogel, obtained through the conjugation of a thiolated hydrophobic molecule to the hyaluronic acid chain. Engineered nanogel was studied for its biocompatibility, including immunocompatibility and hemocompatability. The nanogel did not compromise the metabolic activity or cellular membrane integrity of 3T3, microvascular endothelial cells, and RAW 264.7 cell lines, as determined by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide and lactate dehydrogenase release assays. Also, we didn't observe any apoptotic effect on these cell lines through the Annexin V-FITC test. Furthermore, the nanogel cell internalization was analyzed using murine bone marrow derived macrophages, and the in vivo and ex vivo biodistribution of the Cy5.5 labeled nanogel was monitored using a non-invasive near-infrared fluorescence imaging system. The HyA-AT nanogel exhibits fairly a long half-live in the blood stream, thus showing potential for drug delivery applications., The authors thank the FCT Strategic Project of UID/BIO/04469/2013 unit, the project RECI/ BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and the Project “BioHealth – Biotechnology and Bioengineering approaches to improve health quality”, Ref. NORTE-07-0124- FEDER-000027, co-funded by the Programa Operacional Regional do Norte (ON.2 – O Novo Norte), QREN, FEDER. The authors would like to acknowledge also the support of FCT for the PhD grant reference SFRH/BD/61516/2009. They would also like to thank Bioimaging department on Molecular Medicine Institute (IMM) in Lisbon, namely Dr José Rino and Dr António Temudo. Also thank the animal facilities in IMM (Lisbon), specially Dr. Dolores Bonaparte and Dr. Joana Marques. Finally, the authors thank Dr Africa Gonzalez and Mercedes Pelletero the performance of the studies on the activation of complement.

Agriculture supports up to 75% of the Kenyan population and generates almost all the country’s food requirements. However drought are the major constraints to rain-fed agricultural production, especially in arid and semi arid lands (ASALs) of Kenya which form about 88% of the country. In the last 100 years, Kenya has recorded 28 droughts, three of them in the last decade. The frequency and severity of droughts seems to be increasing in the country over time. The result has been total crop failures and livestock deaths triggering severe food shortages in the country and more specifically in ASAL districts. Between 1993 to date, the government of Kenya has declared 7 national disasters out of which 5 were drought related. These declarations followed the droughts of 1992-93, 1996-97, 1999-2000, 2005-06 and 2008-09 when the Kenya government requested international communities for food aid. About 28 ASAL districts in Kenya have been placed under Emergency Operation Programme (EMOP) due to the heightening food insecurity caused by droughts. This paper highlights the effects of drought on food security in Kenya with special reference to Central and Mukogodo Divisions of the semi arid areas of Laikipia District, Kenya.