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1. Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Belém, Pará, North Region of Brazil.

Author

Ana Beatriz Figueiredo de Lima, Keyla Santos Guedes de Sá, Maria Karoliny da Silva Torres, Luana da Silva Soares, Hugo Reis Resques, Vânia Nakauth Azevedo, Rosimar Neris Martins Feitosa, Jacqueline Cortinhas Monteiro, Andrea Nazaré Monteiro Rangel da Silva, Andre Luis Ribeiro Ribeiro, Aldemir Branco de Oliveira-Filho, Antonio Carlos Rosario Vallinoto, and Luiz Fernando Almeida Machado

Subjects
Medicine, Science
Abstract

INTRODUCTION:Human pegivirus 1 (HPgV-1) is a single-stranded, positive-sense RNA virus belonging to the Flaviviridae family with limited cause-effect evidence of the causation of human diseases. However, studies have shown a potential beneficial impact of HPgV-1 coinfection in HIV disease progression. Human T lymphotropic virus-1 (HTLV-1) is a retrovirus known for causing diseases, especially in muscle and white blood cells, in approximately 5% of patients. Thus, this study aimed to investigate the potential effects of an HPgV-1 infection in patients carrying HTLV-1 in the state of Pará in the North Region of Brazil. METHODS:A group of HTLV-1 carriers was compared to healthy controls. Blood samples were collected, data from medical regards were collected, and a questionnaire was administered. HPgV-1 and HTLV-1 positivity was determined by quantitative polymerase chain reaction (qRT-PCR). The data were analyzed to correlate the effects of HPgV-1 coinfection in HTLV-1 carriers. RESULTS:A total of 158 samples were included in the study: 74 HTLV-1-positive patients (46,8%) and 84 healthy controls (53,2%). The overall HPgV-1 positivity rate was 7.6% (12/158), resulting in a prevalence of 5.4% (4/74) and 9.5% (8/84) in HTLV-1 carriers and healthy controls, respectively. No significant differences were found when comparing any clinical or demographic data between groups. CONCLUSION:This study indicated that the prevalence of HPgV-1 infection is low in HTLV-1 carriers in Belém, Pará, and probably does not alter the clinical course of HTLV-1 infection, however, further studies are still needed.

Published
2020
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2. Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Belém, Pará, North Region of Brazil

Author

Jacqueline Cortinhas Monteiro, Andréa Nazaré Monteiro Rangel da Silva, Maria Karoliny da Silva Torres, Aldemir B. Oliveira-Filho, Luiz Fernando Almeida Machado, Antonio Carlos Rosário Vallinoto, Vânia Nakauth Azevedo, Luana Silva Soares, Ana Beatriz Figueiredo de Lima, Keyla Santos Guedes de Sá, Hugo Reis Resques, Rosimar Neris Martins Feitosa, and André Luis Ribeiro Ribeiro

Subjects
RNA viruses, Male, 0301 basic medicine, Pegiv?rus Humano 1 (HPgV-1), Epidemiology, Infec??es por Flaviviridae, Blood Donors, Pathology and Laboratory Medicine, Geographical locations, White Blood Cells, Immunodeficiency Viruses, Animal Cells, Medicine and Health Sciences, Prevalence, Human T-lymphotropic virus 1, Multidisciplinary, biology, T Cells, Coinfection, Clinical course, virus diseases, Flaviviridae Infections, Middle Aged, Coinfec??o, Infectious Diseases, Real-time polymerase chain reaction, Medical Microbiology, HIV epidemiology, Viral Pathogens, Viruses, Medicine, Flaviviridae / isolamento & purifica??o, Female, Pathogens, Cellular Types, Brazil, Research Article, Hiv disease, Adult, Immune Cells, Science, Pegivirus, Immunology, 030106 microbiology, Sexually Transmitted Diseases, Microbiology, 03 medical and health sciences, Flaviviridae, Retroviruses, medicine, Humans, In patient, Microbial Pathogens, Blood Cells, Biology and life sciences, business.industry, Lentivirus, Organisms, HIV, RNA virus, Htlv-1, Cell Biology, South America, medicine.disease, biology.organism_classification, HTLV-I Infections, V?rus Linfotr?pico T Tipo 1 Humano, Health Care, 030104 developmental biology, Co-Infections, People and places, business
Abstract

This study was financed in part by the Coordenac??o de Aperfeic?oamento de Pessoal de N??vel Superior - Brasil (CAPES) - Finance Code 001. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Programa de P?s-gradua??o em Biologia de Agentes Infecciosos e Parasit?rios. Bel?m, PA, Brazil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Programa de P?s-gradua??o em Biologia de Agentes Infecciosos e Parasit?rios. Bel?m, PA, Brazil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Programa de P?s-gradua??o em Biologia de Agentes Infecciosos e Parasit?rios. Bel?m, PA, Brazil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Laborat?rio de Virologia. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Laborat?rio de Virologia. Ananindeua, PA, Brasil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Virologia. Bel?m, PA, Brazil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Virologia. Bel?m, PA, Brazil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Virologia. Bel?m, PA, Brazil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Virologia. Bel?m, PA, Brazil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Virologia. Bel?m, PA, Brazil. Universidade Federal do Par?. Instituto de Estudos Costeiros. Grupo de Estudo e Pesquisa em Popula??es Vulner?veis. Bragan?a, PA, Brazil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Virologia. Bel?m, PA, Brazil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Programa de P?s-gradua??o em Biologia de Agentes Infecciosos e Parasit?rios. Bel?m, PA, Brazil / Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Virologia. Bel?m, PA, Brazi Introduction - Human pegivirus 1 (HPgV-1) is a single-stranded, positive-sense RNA virus belonging to the Flaviviridae family with limited cause-effect evidence of the causation of human diseases. However, studies have shown a potential beneficial impact of HPgV-1 coinfection in HIV disease progression. Human T lymphotropic virus-1 (HTLV-1) is a retrovirus known for causing diseases, especially in muscle and white blood cells, in approximately 5% of patients. Thus, this study aimed to investigate the potential effects of an HPgV-1 infection in patients carrying HTLV-1 in the state of Par? in the North Region of Brazil. Methods - A group of HTLV-1 carriers was compared to healthy controls. Blood samples were collected, data from medical regards were collected, and a questionnaire was administered. HPgV-1 and HTLV-1 positivity was determined by quantitative polymerase chain reaction (qRT-PCR). The data were analyzed to correlate the effects of HPgV-1 coinfection in HTLV-1 carriers. Results - A total of 158 samples were included in the study: 74 HTLV-1-positive patients (46,8%) and 84 healthy controls (53,2%). The overall HPgV-1 positivity rate was 7.6% (12/158), resulting in a prevalence of 5.4% (4/74) and 9.5% (8/84) in HTLV-1 carriers and healthy controls, respectively. No significant differences were found when comparing any clinical or demographic data between groups. Conclusion - This study indicated that the prevalence of HPgV-1 infection is low in HTLV-1 carriers in Bel?m, Par?, and probably does not alter the clinical course of HTLV-1 infection, however, further studies are still needed.

Published
2020
Full Text
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