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9. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis: An international expert survey and case vignette study

Author

Falconi, Massimo, Zou, Wen-Bin, Engjom, Trond, Ooi, Chee Y., Sutton, Robert, Frulloni, Luca, Neoptolemos, John, Wilcox, Charles, Miroslav, Vujasinovic, Trikudanathan, Guru, Liao, Zhuan, Hauge, Truls, Mössner, Joachim, Hoge, Chantal, Fockens, Paul, Mieog, Sven, Capurso, Gabriele, Cui, Yunfeng, de Madaria, Enrique, Distler, Marius, Aghdassi, Ali, Whitcomb, David C., Russell, Kylie, Beyer, Georg, Kunovsky, Lumír, Kwanten, Wilhelmus, Nava, Andrea Kazemi, Conlon, Kevin, Siriwardena, A.K., Paiella, Salvatore, Alconchel, Felipe, Marino, Marco Vito, de Meijer, Vincent E., Domingo, Carlos, Kleeff, Jorg, Lakshmanan, Aarti, Lie Chu, Michael Jen, Bouwense, Stefan, Nashidengo, Pueya Rashid, Konstantinos, Perivoliotis, Muttillo, Edoardo Maria, Umar, Garzali Ibrahim, Castro Santiago, Maria Jesus, Lopez-Lopez, Victor, Torri, Francesco, Schmelzle, Moritz, Ignatavicius, Povilas, Wicherts, Dennis, Gomes, Antonio, Machairas, Nikolaos A., Dorovinis, Panagiotis I., Serrablo, Alejandro, Soreide, Kjetil, Rahbari, Mohammad, Jie Chu, Michael Jen, Ptasnuka, Margarita, Petrulionis, Marius, Noel, Colin Byron, Castro, Ernest, Di Martino, Marcello, Recordare, Alfonso, Stättner, Stefan, Ausania, Fabio, Hartman, Vera, Roeyen, Geert, Egorov, Viacheslav, Vanagas, Tomas, Ebrahim, Mohamed, Arabadzhieva, Elena, Malleo, Giuseppe, Li, Liang, Adams, David, Oracz, Grzegorz, Nageshwar, Reddy D., Waldthaler, Alexander, Masamune, Atsushi, Drewes, Asbjorn Mohr, Amodio, Antonio, Tirkes, Temel, Srivastava, Anshu, Beilman, Gregory J., Berger, Zoltan, Lindkvist, Bjorn, Cavestro, Giulia Martina, Gariepy, Cheryl, Czakó, Laszlo, Di Leo, Milena, Sharma, Vishal, Lakhtakia, Sundeep, Rana, Surinder Singh, Duggan, Sinaed N., Kwon, Chang-Il, Phillips, Anna Evans, Forsmark, Christopher E., Gleeson, Ferga C., Lehman, Glen A., Greenhalf, William, Costamagna, Guido, Halloran, Christopher M., Friess, Helmut, Rasmussen, Henrik Hojgaard, Ikeura, Tsukasa, Haldorsen, Ingfrid S., Itoi, Takao, Izbicki, Jacob R., Windsor, John, Poulsen, Jakob Lykke, Frokjaer, Jens Brondum, Larino-Noia, Jose, Wang, Dan, Garcia, Julio Iglesias, Kalaitzakis, Evangelos, Wertheim-Tysarowska, Kararzyna, Kubota, Kensuke, Larusch, Jessica, Lerch, Markus M., Hu, Liang-Hao, Erkan, Mert, Machicado, Jorg D., Arvanitakis, Marianna, Buchler, Markus W., Levy, Marlon F., Heyman, Melvin B., Nojgaard, Camilla, Khashab, Mouen A., Delhaye, Myriam, Ogura, Takeshi, Okazaki, Kazuichi, Ghaneh, Paula, Banks, Peter A., Gupta, Pankaj, Papachristou, Georgios I., Michl, Patrick, Levy, Philippe, Pukitis, Aldis, Pezzilli, Raffaele, Baron, Ryan D., Amann, Stephen T., Schwarzenberg, Sarah Jane, Isaji, Shuiji, Olesen, Soren Schou, Novovic, Srdan, Hughes, Steven J., Werlin, Steven L., Gonska, Tanja, Gardner, Timothy B., Topazian, Mark D., Weiss, Frank Ulrich, Akshintala, Venakata S., Morinville, Veronique D., Rebours, Vinciane, Vincze, Aron, Singh, Vikesh K., Cui, Naiqiang, Zhang, Hong, Li, Zhao-shen, de Rijk, Florence E.M., van Veldhuisen, Charlotte L., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., van Geenen, Erwin J.M., Hegyi, Peter, Löhr, J-Matthias, Dominguez-Munoz, Juan E., de Jonge, Pieter Jan F., Bruno, Marco J., and Verdonk, Robert C.

Published
2022
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10. A risk-adjusted analysis of drain use in pancreaticoduodenectomy: Some is good, but more may not be better

Author

Brubaker, Lisa S., Casciani, Fabio, Fisher, William E., Wood, Amy L., Cagigas, Martha Navarro, Trudeau, Maxwell T., Parikh, Viraj J., Baugh, Katherine A., Asbun, Horacio J., Ball, Chad G., Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Christein, John D., Fernandez-del Castillo, Carlos, Dillhoff, Mary E., Dixon, Elijah, House, Michael G., Hughes, Steven J., Kent, Tara S., Kunstman, John W., Wolfgang, Christopher L., Zureikat, Amer H., Vollmer, Charles M., Jr., and Van Buren, George, II

Published
2022
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11. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage

Author

Fisher, William E, Cruz-Monserrate, Zobeida, McElhany, Amy L, Lesinski, Gregory B, Hart, Phil A, Ghosh, Ria, Van Buren, George, Fishman, Douglas S, Rinaudo, Jo Ann S, Serrano, Jose, Srivastava, Sudhir, Mace, Thomas, Topazian, Mark, Feng, Ziding, Yadav, Dhiraj, Pandol, Stephen J, Hughes, Steven J, Liu, Robert Y, Lu, Emily, Orr, Robert, Whitcomb, David C, Abouhamze, Amer S, Steen, Hanno, Sellers, Zachary M, Troendle, David M, Uc, Aliye, Lowe, Mark E, and Conwell, Darwin L

Subjects
Digestive Diseases, Cancer, Rare Diseases, Clinical Research, Diabetes, Pancreatic Cancer, Metabolic and endocrine, Biological Specimen Banks, Biomedical Research, Child, Diabetes Mellitus, Guidelines as Topic, Humans, Pancreatic Neoplasms, Pancreatitis, Chronic, Preservation, Biological, Specimen Handling, biorepository, biospecimens, pancreas, standard operating procedures, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Clinical Sciences, Gastroenterology & Hepatology
Abstract

High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults. Standard operating procedures from the CPDPC centers were evaluated and consolidated. The literature was reviewed for standard biorepository operating procedures that facilitated downstream molecular analysis. The existing literature on biobanking practices was harmonized with the SOPs from the clinical centers to produce a biorepository for pancreatic research. This article reports the methods and basic principles behind the creation of SOPs to develop a biorepository for the CPDPC. These will serve as a guide for investigators developing biorepositories in pancreas research. Rigorous and meticulous adherence to standardized biospecimen collection will facilitate investigations to better understand the pathophysiology and biologic mechanisms of CP, diabetes, and pancreatic cancer.

Published
2018

12. A Prospective Study to Establish a New-Onset Diabetes Cohort

Author

Maitra, Anirban, Sharma, Ayush, Brand, Randall E, Van Den Eeden, Stephen K, Fisher, William E, Hart, Phil A, Hughes, Steven J, Mather, Kieren J, Pandol, Stephen J, Park, Walter G, Feng, Ziding, Serrano, Jose, Rinaudo, Jo Ann S, Srivastava, Sudhir, and Chari, Suresh T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Diabetes, Prevention, Cancer, Rare Diseases, Pancreatic Cancer, Digestive Diseases, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Metabolic and endocrine, Good Health and Well Being, Biomedical Research, Blood Specimen Collection, Carcinoma, Pancreatic Ductal, Diabetes Mellitus, Type 2, Early Diagnosis, Humans, Middle Aged, Pancreatic Neoplasms, Pancreatitis, Chronic, Prospective Studies, Research Design, Young Adult, screening, sporadic pancreatic cancer, diabetes, high-risk group, biomarker, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Gastroenterology & Hepatology, Clinical sciences
Abstract

The National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases initiated the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) in 2015 (the CPDPC's origin, structure, governance, and research objectives are described in another article in this journal). One of the key objectives of CPDPC is to assemble a cohort of 10,000 subjects 50 years or older with new-onset diabetes, called the NOD cohort. Using a define, enrich, and find early detection approach, the aims of the NOD study are to (a) estimate the 3-year probability of pancreatic ductal adenocarcinoma (PDAC) in NOD (define), (b) establish a biobank of clinically annotated biospecimens from presymptomatic PDAC and control new-onset type 2 diabetes mellitus subjects, (c) conduct phase 3 validation studies of promising biomarkers for identification of incident PDAC in NOD patients (enrich), and (d) provide a platform for development of a future interventional screening protocol for early detection of PDAC in patients with NOD that incorporates imaging studies and/or clinical algorithms (find). It is expected that 85 to 100 incidences of PDAC will be diagnosed during the study period in this cohort of 10,000 patients.

Published
2018

13. PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies

Author

Yadav, Dhiraj, Park, Walter G, Fogel, Evan L, Li, Liang, Chari, Suresh T, Feng, Ziding, Fisher, William E, Forsmark, Christopher E, Jeon, Christie Y, Habtezion, Aida, Hart, Phil A, Hughes, Steven J, Othman, Mohamed O, Rinaudo, Jo Ann S, Pandol, Stephen J, Tirkes, Temel, Serrano, Jose, Srivastava, Sudhir, Van Den Eeden, Stephen K, Whitcomb, David C, Topazian, Mark, and Conwell, Darwin L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pancreatic Cancer, Prevention, Digestive Diseases, Rare Diseases, Cancer, Clinical Research, 2.1 Biological and endogenous factors, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Aetiology, Oral and gastrointestinal, Adult, Biomarkers, Blood Specimen Collection, Diabetes Mellitus, Disease Progression, Humans, Longitudinal Studies, Observational Studies as Topic, Outcome Assessment, Health Care, Pancreatic Neoplasms, Pancreatitis, Chronic, Prospective Studies, Research Design, Specimen Handling, Translational Research, Biomedical, United States, pancreas, alcohol, tobacco, genetic, biorepository, cohort, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Gastroenterology & Hepatology, Clinical sciences
Abstract

Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) is the first prospective, observational cohort study of chronic pancreatitis (CP) in the United States. The primary goals of PROCEED are to define disease progression, test the predictive capability of candidate biomarkers, and develop a platform to conduct translational and mechanistic studies in CP. Using objective and consensus-driven criteria, PROCEED will enroll adults at different stages of CP-controls, suspected CP, and definite CP. In addition to collecting detailed information using structured case report forms and protocol-mandated evaluations at baseline and during follow-up, PROCEED will establish a linked biorepository of blood, urine, saliva, stool, pancreatic fluid, and pancreatic tissue. Enrollment for PROCEED began in June 2017. As of July 1, 2018, nine clinical centers of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer are enrolling, and 350 subjects have completed baseline evaluation. In conclusion, PROCEED will provide the most accurate and reliable estimates to date on progression of CP. The established cohort and biorepository will facilitate numerous analyses, leading to new strategies for diagnosis, methods to monitor disease progression, and treatment of CP.

Published
2018

14. Supplementary Table S4 from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
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15. Figure S2 from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
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16. Table S2 from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
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17. Data from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
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18. The effect of high intraoperative blood loss on pancreatic fistula development after pancreatoduodenectomy: An international, multi-institutional propensity score matched analysis

Author

Fisher, William E., Van Buren, George, II, Callery, Mark P., Kent, Tara S., Pratt, Wande B., Vollmer, Charles M., Jr., Watkins, Ammara A., House, Michael G., Beane, Joal D., Berger, Adam C., Wolfgang, Christopher L., Javed, Ammar A., Poruk, Katherine E., Soares, Kevin C., Valero, Vicente, III, Fernandez-del Castillo, Carlos, Fong, Zhi V., Asbun, Horacio J., Stauffer, John A., Bloomston, Mark P., Dilhoff, Mary E., Haverick, Ericka N., Schmidt, Carl R., Christein, John D., Hollis, Robert H., Ball, Chad G., Dixon, Elijah, Hughes, Steven J., Drebin, Jeffrey A., Ecker, Brett, Lewis, Russell, Jr., McMillan, Matthew, Miller, Benjamin, Puri, Priya, Seykora, Thomas, Sprys, Michael J., Zureikat, Amer H., Kowalsky, Stacy J., Behrman, Stephen W., Bassi, Claudio, Casciani, Fabio, Maggino, Laura, Malleo, Giuseppe, Salvia, Roberto, Savegnago, Giulia, Cinelli, Lorenzo, Falconi, Massimo, Partelli, Stefano, Dickson, Euan J., Jamieson, Nigel B., Velu, Lavanniya K.P., Salem, Ronald R., Kunstman, John W., Trudeau, Maxwell T., Dillhoff, Mary E., and Vollmer, Charles M.

Published
2021
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20. Surgeon experience contributes to improved outcomes in pancreatoduodenectomies at high risk for fistula development

Author

Fisher, William E., Van Buren, George, II, Callery, Mark P., Kent, Tara S., Pratt, Wande B., Vollmer, Charles M., Jr., Watkins, Ammara A., House, Michael G., Beane, Joal D., Berger, Adam C., Wolfgang, Christopher L., Javed, Ammar A., Poruk, Katherine E., Soares, Kevin C., Valero, Vicente, III, Fernandez-del Castillo, Carlos, Fong, Zhi V., Asbun, Horacio J., Stauffer, John A., Bloomston, Mark P., Dilhoff, Mary E., Haverick, Ericka N., Schmidt, Carl R., Christein, John D., Hollis, Robert H., Ball, Chad G., Dixon, Elijah, Hughes, Steven J., Drebin, Jeffrey A., Ecker, Brett, Lewis, Russell, Jr., McMillan, Matthew, Miller, Benjamin, Puri, Priya, Seykora, Thomas, Sprys, Michael J., Zureikat, Amer H., Kowalsky, Stacy J., Behrman, Stephen W., Bassi, Claudio, Casciani, Fabio, Maggino, Laura, Malleo, Giuseppe, Salvia, Roberto, Savegnago, Giulia, Cinelli, Lorenzo, Falconi, Massimo, Partelli, Stefano, Dickson, Euan J., Jamieson, Nigel B., Velu, Lavanniya K.P., Salem, Ronald R., Kunstman, John W., Trudeau, Maxwell T., and Dillhoff, Mary E.

Published
2021
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21. The Influence of Intraoperative Blood Loss on Fistula Development Following Pancreatoduodenectomy

Author

Trudeau, Maxwell T., Casciani, Fabio, Maggino, Laura, Seykora, Thomas F., Asbun, Horacio J., Ball, Chad G., Bassi, Claudio, Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Castillo, Carlos Fernandez-del, Christein, John D., Dillhoff, Mary E., Dickson, Euan J., Dixon, Elijah, Fisher, William E., House, Michael G., Hughes, Steven J., Kent, Tara S., Malleo, Giuseppe, Salem, Ronald R., Wolfgang, Christopher L., Zureikat, Amer H., and Vollmer, Charles M.

Published
2022
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27. Results of a phase II, open-label pilot study evaluating the safety and activity of liposomal irinotecan (Nal-IRI) in combination with 5-FU and oxaliplatin (NALIRIFOX) in preoperative treatment of pancreatic adenocarcinoma (NEO-Nal-IRI study).

Author

George, Thomas J., primary, Rogers, Sherise C., additional, Nassour, Ibrahim, additional, Sahin, Ilyas, additional, Ramnaraign, Brian Hemendra, additional, Fabregas, Jesus, additional, Hitchcock, Kathryn, additional, Lin, Tuo, additional, Liu, Gonghao, additional, Zlotecki, Robert, additional, Kayaleh, Omar Roger, additional, Turk, Anita Ahmed, additional, Fan, Z. Hugh, additional, Russell, Karen Bullock, additional, DeRemer, David L., additional, Lee, Ji-Hyun, additional, and Hughes, Steven J., additional

Published
2024
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29. Interventions for Pancreatitis—New Approaches, Knowledge Gaps, and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Author

Phillips, Anna Evans, Hughes, Steven J., Andersen, Dana K., Bell, Adam, Brand, Randall, Coté, Gregory A., Cowdin, Adriana, Diazgranados, Nancy, Dudeja, Vikas, Duggan, Sinead N., Fogel, Evan, Forsmark, Chris E., Freeman, A. Jay, Gittes, George, Hart, Phil A., Jeon, Christie, Nealon, William, Neoptolemos, John, Palermo, Tonya M., and Pandol, Stephen

Published
2024
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30. Prognosis and Treatment Outcomes of Bone Metastasis in Gallbladder Adenocarcinoma: A SEER-Based Study

Author

Gera, Kriti, primary, Kahramangil, Doga, additional, Fenton, Graeme A., additional, Martir, Daniela, additional, Rodriguez, Diana N., additional, Ijaz, Zohaib, additional, Lin, Rick Y., additional, Rogers, Sherise C., additional, Ramnaraign, Brian H., additional, George, Thomas J., additional, Hong, Young-Rock, additional, Hughes, Steven J., additional, Nassour, Ibrahim, additional, and Sahin, Ilyas, additional

Published
2023
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31. A phase II study of neoadjuvant liposomal irinotecan with 5-FU and oxaliplatin (NALIRIFOX) in pancreatic adenocarcinoma

Author

Singhal, Ruchi, primary, Rogers, Sherise C, additional, Lee, Ji-Hyun, additional, Ramnaraign, Brian, additional, Sahin, Ilyas, additional, Fabregas, Jesus C, additional, Thomas, Ryan M., additional, Hughes, Steven J, additional, Nassour, Ibrahim, additional, Hitchcock, Kathryn, additional, Russell, Karen, additional, Kayaleh, Omar, additional, Turk, Anita, additional, Zlotecki, Robert, additional, DeRemer, David L, additional, and George, Thomas J, additional

Published
2023
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34. Multicenter evaluation of the clinical utility of laparoscopy-assisted ERCP in patients with Roux-en-Y gastric bypass

Author

Ponsky, Jeffrey, Greenwald, Bruce D., Uradomo, Lance T., McGhan, Alyson A., Hakimian, Shahrad, Ross, Andrew, Sherman, Stuart, Bick, Benjamin L., Forsmark, Christopher E., Yang, Dennis, Gupte, Anand, Chauhan, Shailendra, Hughes, Steven J., Saks, Karen, Bakis, Gennadiy, Templeton, Adam W., Saunders, Michael, Sedarat, Alireza, Evans, John A., Muniraj, Thiruvengadam, Gardner, Timothy B., Ramos, Almino C., Santo, Marco Aurelio, Nett, Andrew, Coté, Gregory A., Elmunzer, B. Joseph, Dua, Kulwinder S., Nosler, Michael J., Strand, Daniel S., Yeaton, Paul, Kothari, Shivangi, Ullah, Asad, Taunk, Pushpak, Brady, Patrick, Pinkas, Haim, Faulx, Ashley L., Shahid, Haroon, Holmes, Jordan, Pannu, Davinderbir, Komanduri, Srinadh, Bucobo, Juan Carlos, Dhaliwal, Harry, Rostom, Alaa, Acker, Brent W., Abbas, Ali M., Strong, Andrew T., Diehl, David L., Brauer, Brian C., Lee, Iris H., Burbridge, Rebecca, Zivny, Jaroslav, Higa, Jennifer T., Falcão, Marcelo, El Hajj, Ihab I., Tarnasky, Paul, Enestvedt, Brintha K., Ende, Alexander R., Thaker, Adarsh M., Pawa, Rishi, Jamidar, Priya, Sampath, Kartik, de Moura, Eduardo Guimarães Hourneaux, Kwon, Richard S., Suarez, Alejandro L., Aburajab, Murad, Wang, Andrew Y., Shakhatreh, Mohammad H., Kaul, Vivek, Kang, Lorna, Kowalski, Thomas E., Pannala, Rahul, Tokar, Jeffrey, Aadam, A. Aziz, Tzimas, Demetrios, Wagh, Mihir S., and Draganov, Peter V.

Published
2018
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35. The Influence of Intraoperative Blood Loss on Fistula Development Following Pancreatoduodenectomy

Author

Trudeau, Maxwell T., Casciani, Fabio, Maggino, Laura, Seykora, Thomas F., Asbun, Horacio J., Ball, Chad G., Bassi, Claudio, Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Castillo, Carlos Fernandez-del, Christein, John D., Dillhoff, Mary E., Dickson, Euan J., Dixon, Elijah, Fisher, William E., House, Michael G., Hughes, Steven J., Kent, Tara S., Malleo, Giuseppe, Salem, Ronald R., Wolfgang, Christopher L., Zureikat, Amer H., and Vollmer, Charles M.

Published
2020
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36. The Fistula Risk Score Catalog: Toward Precision Medicine for Pancreatic Fistula After Pancreatoduodenectomy

Author

Trudeau, Maxwell T., Casciani, Fabio, Ecker, Brett L., Maggino, Laura, Seykora, Thomas F., Puri, Priya, McMillan, Matthew T., Miller, Benjamin, Pratt, Wande B., Asbun, Horacio J., Ball, Chad G., Bassi, Claudio, Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Castillo, Carlos Fernandez-del, Christein, John D., Dillhoff, Mary E., Dickson, Euan J., Dixon, Elijah, Fisher, William E., House, Michael G., Hughes, Steven J., Kent, Tara S., Malleo, Giuseppe, Salem, Ronald R., Wolfgang, Christopher L., Zureikat, Amer H., and Vollmer, Charles M.

Published
2020
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39. Minimally invasive pancreatoduodenectomy

Author

Asbun, Horacio J., Barkun, Jeffrey, Besselink, Marc GH., Boggi, Ugo, Conlon, Kevin CP., Han, Ho-Seong, Hansen, Paul D., Kendrick, Michael L., Kooby, David A., Montagnini, Andre L., Palanivelu, C., Røsok, Bård I., Shrikhande, Shailesh V., Wakabayashi, Go, Zeh, Herbert, Vollmer, Charles M., van Hilst, Jony, de Rooij, Thijs, Walsh, R. Matthew, Zeh, Herbert J., Hughes, Steven J., and Nakamura, Yoshiharu

Published
2017
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40. Infiltration of CD3+ and CD8+ lymphocytes in association with inflammation and survival in pancreatic cancer.

Author

Tushoski-Alemán, Gerik W., Herremans, Kelly M., Underwood, Patrick W., Akki, Ashwin, Riner, Andrea N., Trevino, Jose G., Han, Song, and Hughes, Steven J.

Subjects
CD8 antigen, CD3 antigen, PANCREATIC cancer, LYMPHOCYTES, ENZYME-linked immunosorbent assay
Abstract

Background: Pancreatic ductal adenocarcinomas (PDAC) have heterogeneous tumor microenvironments relatively devoid of infiltrating immune cells. We aimed to quantitatively assess infiltrating CD3+ and CD8+ lymphocytes in a treatment-naïve patient cohort and assess associations with overall survival and microenvironment inflammatory proteins. Methods: Tissue microarrays were immunohistochemically stained for CD3+ and CD8+ lymphocytes and quantitatively assessed using QuPath. Levels of inflammation-associated proteins were quantified by multiplexed, enzyme-linked immunosorbent assay panels on matching tumor and tissue samples. Results: Our findings revealed a significant increase in both CD3+ and CD8+ lymphocytes populations in PDAC compared with non-PDAC tissue, except when comparing CD8+ percentages in PDAC versus intraductal papillary mucinous neoplasms (IPMN) (p = 0.5012). Patients with quantitatively assessed CD3+ low tumors (lower 50%) had shorter survival (median 273 days) compared to CD3+ high tumors (upper 50%) with a median overall survival of 642.5 days (p = 0.2184). Patients with quantitatively assessed CD8+ low tumors had significantly shorter survival (median 240 days) compared to CD8+ high tumors with a median overall survival of 1059 days (p = 0.0003). Of 41 proteins assessed in the inflammation assay, higher levels of IL-1B and IL-2 were significantly associated with decreased CD3+ infiltration (r = -0.3704, p = 0.0187, and r = -0.4275, p = 0.0074, respectively). Higher levels of IL-1B were also significantly associated with decreased CD8+ infiltration (r = -0.4299, p = 0.0045), but not IL-2 (r = -0.0078, p = 0.9616). Principal component analysis of the inflammatory analytes showed diverse inflammatory responses in PDAC. Conclusion: In this work, we found a marked heterogeneity in infiltrating CD3+ and CD8+ lymphocytes and individual inflammatory responses in PDAC. Future mechanistic studies should explore personalized therapeutic strategies to target the immune and inflammatory components of the tumor microenvironment. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Supplemental Figure S1 from Nicotine Reduces Survival via Augmentation of Paracrine HGF–MET Signaling in the Pancreatic Cancer Microenvironment

Author

Delitto, Daniel, primary, Zhang, Dongyu, primary, Han, Song, primary, Black, Brian S., primary, Knowlton, Andrea E., primary, Vlada, Adrian C., primary, Sarosi, George A., primary, Behrns, Kevin E., primary, Thomas, Ryan M., primary, Lu, Xiaomin, primary, Liu, Chen, primary, George, Thomas J., primary, Hughes, Steven J., primary, Wallet, Shannon M., primary, and Trevino, Jose G., primary

Published
2023
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44. Data from Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment

Author

Delitto, Daniel, primary, Delitto, Andrea E., primary, DiVita, Bayli B., primary, Pham, Kien, primary, Han, Song, primary, Hartlage, Emily R., primary, Newby, Brittney N., primary, Gerber, Michael H., primary, Behrns, Kevin E., primary, Moldawer, Lyle L., primary, Thomas, Ryan M., primary, George, Thomas J., primary, Brusko, Todd M., primary, Mathews, Clayton E., primary, Liu, Chen, primary, Trevino, Jose G., primary, Hughes, Steven J., primary, and Wallet, Shannon M., primary

Published
2023
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45. Supplementary Figures 1 through 3 from Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment

Author

Delitto, Daniel, primary, Delitto, Andrea E., primary, DiVita, Bayli B., primary, Pham, Kien, primary, Han, Song, primary, Hartlage, Emily R., primary, Newby, Brittney N., primary, Gerber, Michael H., primary, Behrns, Kevin E., primary, Moldawer, Lyle L., primary, Thomas, Ryan M., primary, George, Thomas J., primary, Brusko, Todd M., primary, Mathews, Clayton E., primary, Liu, Chen, primary, Trevino, Jose G., primary, Hughes, Steven J., primary, and Wallet, Shannon M., primary

Published
2023
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48. A phase II, open-label pilot study evaluating the safety and activity of liposomal irinotecan (Nal-IRI) in combination with 5-FU and oxaliplatin (NALIRIFOX) in preoperative treatment of pancreatic adenocarcinoma (NEO-Nal-IRI Study).

Author

Rogers, Sherise C., primary, Sahin, Ilyas, additional, Fabregas, Jesus C., additional, Nassour, Ibrahim, additional, Ramnaraign, Brian Hemendra, additional, Hitchcock, Kathryn, additional, Hughes, Steven J., additional, Lee, Ji-Hyun, additional, Kayaleh, Omar Roger, additional, Turk, Anita Ahmed, additional, Fan, Z. Hugh, additional, Russell, Karen Bullock, additional, DeRemer, David L., additional, and George, Thomas J., additional

Published
2023
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49. Low vs Standard-Dose Indocyanine Green in the Identification of Biliary Anatomy Using Near-Infrared Fluorescence Imaging: A Multicenter Randomized Controlled Trial

Author

Ladd, Alexandra D, primary, Zarate Rodriguez, Jorge, additional, Lewis, Duncan, additional, Warren, Curtis, additional, Duarte, Sergio, additional, Loftus, Tyler J, additional, Nassour, Ibrahim, additional, Soma, Daiki, additional, Hughes, Steven J, additional, Hammill, Chet, additional, and Zarrinpar, Ali, additional

Published
2023
Full Text
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