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13 results on '"Hughes, Stella E"'

1. Real‐world persistence of multiple sclerosis disease‐modifying therapies

Author

Tallantyre, Emma C., primary, Dobson, Ruth, additional, Froud, Joseph L. J., additional, St John, Frederika A., additional, Anderson, Valerie M., additional, Arun, Tarunya, additional, Buckley, Lauren, additional, Evangelou, Nikos, additional, Ford, Helen L., additional, Galea, Ian, additional, George, Sumi, additional, Gray, Orla M., additional, Hibbert, Aimee M., additional, Hu, Mo, additional, Hughes, Stella E., additional, Ingram, Gillian, additional, Kalra, Seema, additional, Lim, Chia‐Hui E., additional, Mathews, Joela T. M., additional, McDonnell, Gavin V., additional, Mescall, Naomi, additional, Norris, Sam, additional, Ramsay, Stephen J., additional, Rice, Claire M., additional, Russell, Melanie J., additional, Shawe‐Taylor, Marianne J., additional, Williams, Thomas E., additional, Harding, Katharine E., additional, and Robertson, Neil P., additional

Published
2024
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2. Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis: An International Registry Study

Author

Vitkova, Marianna, Diouf, Ibrahima, Malpas, Charles, Horakova, Dana, Kubala Havrdova, Eva, Patti, Francesco, Ozakbas, Serkan, Izquierdo, Guillermo, Eichau, Sara, Shaygannejad, Vahid, Onofrj, Marco, Lugaresi, Alessandra, Alroughani, Raed, Prat, Alexandre, Larochelle, Catherine, Girard, Marc, Duquette, Pierre, Terzi, Murat, Boz, Cavit, Grand'Maison, Francois, Sola, Patrizia, Ferraro, Diana, Grammond, Pierre, Butzkueven, Helmut, Buzzard, Katherine, Skibina, Olga, Yamout, Bassem I, Karabudak, Rana, Gerlach, Oliver, Lechner-Scott, Jeannette, Maimone, Davide, Bergamaschi, Roberto, Van Pesch, Vincent, Iuliano, Gerardo, Cartechini, Elisabetta, José Sà, Maria, Ampapa, Radek, Barnett, Michael, Hughes, Stella E, Ramo-Tello, Cristina M, Hodgkinson, Suzanne, Spitaleri, Daniele L A, Petersen, Thor, Butler, Ernest Gerard, Slee, Mark, McGuigan, Chris, McCombe, Pamela Ann, Granella, Franco, Cristiano, Edgardo, Prevost, Julie, Taylor, Bruce V, Sãnchez-Menoyo, Josã Luis, Laureys, Guy, Van Hijfte, Liesbeth, Vucic, Steve, Macdonell, Richard A, Gray, Orla, Olascoaga, Javier, Deri, Norma, Fragoso, Yara Dadalti, Shaw, Cameron, Kalincik, Tomas, MSBase Study Group, and UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire

Subjects
Male, Disability Evaluation, Multiple Sclerosis, Ultraviolet Rays, Sunlight, Humans, Female, Neurology (clinical), Registries, Severity of Illness Index, Research Article
Abstract

Background and ObjectivesThe severity of multiple sclerosis (MS) varies widely among individuals. Understanding the determinants of this heterogeneity will help clinicians optimize the management of MS. The aim of this study was to investigate the association between latitude of residence, UV B radiation (UVB) exposure, and the severity of MS.MethodsThis observational study used the MSBase registry data. The included patients met the 2005 or 2010 McDonald diagnostic criteria for MS and had a minimum dataset recorded in the registry (date of birth, sex, clinic location, date of MS symptom onset, disease phenotype at baseline and censoring, and ≥1 Expanded Disability Status Scale score recorded). The latitude of each study center and cumulative annualized UVB dose at study center (calculated from National Aeronautics and Space Administration’s Total Ozone Mapping Spectrometer) at ages 6 and 18 years and the year of disability assessment were calculated. Disease severity was quantified with Multiple Sclerosis Severity Score (MSSS). Quadratic regression was used to model the associations between latitude, UVB, and MSSS.ResultsThe 46,128 patients who contributed 453,208 visits and a cumulative follow-up of 351,196 patient-years (70% women, mean age 39.2 ± 12 years, resident between latitudes 19°35′ and 56°16′) were included in this study. Latitude showed a nonlinear association with MS severity. In latitudes DiscussionIn temperate zones, MS severity is associated with latitude. This association is mainly, but not exclusively, driven by UVB exposure contributing to both MS susceptibility and severity.

Published
2022

4. The MSBase pregnancy, neonatal outcomes, and women’s health registry

Author

Jokubaitis, Vilija G., primary, Skibina, Olga, additional, Alroughani, Raed, additional, Altintas, Ayse, additional, Butzkueven, Helmut, additional, Eichau, Sara, additional, Fragoso, Yara, additional, Hellwig, Kerstin, additional, Hughes, Stella E., additional, Rath, Louise, additional, van der Walt, Anneke, additional, and Gray, Orla, additional

Published
2021
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5. Fast Facts: Multiple Sclerosis : A New Era of Disease Modification and Treatment

Author

Hughes, Stella E., Macaron, Gabrielle, Hughes, Stella E., and Macaron, Gabrielle

Subjects
Multiple sclerosis, Multiple sclerosis--Treatment
Abstract

Multiple sclerosis (MS) is a leading cause of disability in young adults, carrying a considerable individual and societal economic burden. The development of disease-modifying therapies and updates to diagnostic criteria are leading us into a new era for MS management, both in the earliest disease phases and progressive MS. In this completely revised/fully updated edition of Fast Facts: Multiple Sclerosis, we present the most recent evidence on disease pathogenesis and all clinical aspects of the condition, as well as the latest on disease-modifying therapies and other potential treatments. Given the need for multidisciplinary management of MS, we have written this resource for the benefit of all health professionals involved in MS care. Table of Contents: • Epidemiology and genetics • Pathology • The clinical picture • Treatment of relapses and symptoms • Disease-modifying treatment • Emerging therapies • Special MS populations • Lifestyle considerations and the multidisciplinary team • Advanced MS

Published
2021

8. Predictors and dynamics of postpartum relapses in women with multiple sclerosis

Author

UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de neurologie, Hughes, Stella E, Spelman, Tim, Gray, Orla M, Boz, Cavit, Trojano, Maria, Lugaresi, Alessandra, Izquierdo, Guillermo, Duquette, Pierre, Girard, Marc, Grand'maison, Francois, MSBase study group, Grammond, Pierre, Oreja-Guevara, Celia, Hupperts, Raymond, Bergamaschi, Roberto, Giuliani, Giorgio, Lechner-Scott, Jeannette, Barnett, Michael, Edite Rio, Maria, Van Pesch, Vincent, Amato, Maria Pia, Iuliano, Gerardo, Slee, Mark, Verheul, Freek, Cristiano, Edgardo, Fernández-Bolaños, Ricardo, Poehlau, Dieter, Saladino, Maria Laura, Deri, Norma, Cabrera-Gomez, Jose, Vella, Norbert, Herbert, Joseph, Skromne, Eli, Savino, Aldo, Shaw, Cameron, Moore, Fraser, Vucic, Steve, Petkovska-Boskova, Tatjana, McDonnell, Gavin, Hawkins, Stanley, Kee, Frank, Butzkueven, Helmut, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de neurologie, Hughes, Stella E, Spelman, Tim, Gray, Orla M, Boz, Cavit, Trojano, Maria, Lugaresi, Alessandra, Izquierdo, Guillermo, Duquette, Pierre, Girard, Marc, Grand'maison, Francois, MSBase study group, Grammond, Pierre, Oreja-Guevara, Celia, Hupperts, Raymond, Bergamaschi, Roberto, Giuliani, Giorgio, Lechner-Scott, Jeannette, Barnett, Michael, Edite Rio, Maria, Van Pesch, Vincent, Amato, Maria Pia, Iuliano, Gerardo, Slee, Mark, Verheul, Freek, Cristiano, Edgardo, Fernández-Bolaños, Ricardo, Poehlau, Dieter, Saladino, Maria Laura, Deri, Norma, Cabrera-Gomez, Jose, Vella, Norbert, Herbert, Joseph, Skromne, Eli, Savino, Aldo, Shaw, Cameron, Moore, Fraser, Vucic, Steve, Petkovska-Boskova, Tatjana, McDonnell, Gavin, Hawkins, Stanley, Kee, Frank, and Butzkueven, Helmut

Abstract

BACKGROUND: Several studies have shown that pregnancy reduces multiple sclerosis (MS) relapses, which increase in the early postpartum period. Postpartum relapse risk has been predicted by pre-pregnancy disease activity in some studies. OBJECTIVE: To re-examine effect of pregnancy on relapses using the large international MSBase Registry, examining predictors of early postpartum relapse. METHODS: An observational case-control study was performed including pregnancies post-MS onset. Annualised relapse rate (ARR) and median Expanded Disability Status Scale (EDSS) scores were compared for the 24 months pre-conception, pregnancy and 24 months postpartum periods. Clustered logistic regression was used to investigate predictors of early postpartum relapses. RESULTS: The study included 893 pregnancies in 674 females with MS. ARR (standard error) pre-pregnancy was 0.32 (0.02), which fell to 0.13 (0.03) in the third trimester and rose to 0.61 (0.06) in the first three months postpartum. Median EDSS remained unchanged. Pre-conception ARR and disease-modifying treatment (DMT) predicted early postpartum relapse in a multivariable model. CONCLUSION: Results confirm a favourable effect on relapses as pregnancy proceeds, and an early postpartum peak. Pre-conception DMT exposure and low ARR were independently protective against postpartum relapse. This novel finding could provide clinicians with a strategy to minimise postpartum relapse risk in women with MS planning pregnancy.

Published
2014

9. Increasing age at disability milestones among MS patients in the MSBase Registry.

Author

UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de neurologie, Kister, Ilya, Chamot, Eric, Cutter, Gary, Bacon, Tamar E, Jokubaitis, Vilija G, Hughes, Stella E, Gray, Orla M, Trojano, Maria, Izquierdo, Guillermo, Grand'Maison, Francois, Duquette, Pierre, Lugaresi, Alessandra, Grammond, Pierre, Boz, Cavit, Hupperts, Raymond, Petersen, Thor, Giuliani, Giorgio, Oreja-Guevara, Celia, Iuliano, Gerardo, Lechner-Scott, Jeannette, Bergamaschi, Roberto, Rio, Maria Edite, Verheul, Freek, Fiol, Marcela, Van Pesch, Vincent, Slee, Mark, Butzkueven, Helmut, Herbert, Joseph, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de neurologie, Kister, Ilya, Chamot, Eric, Cutter, Gary, Bacon, Tamar E, Jokubaitis, Vilija G, Hughes, Stella E, Gray, Orla M, Trojano, Maria, Izquierdo, Guillermo, Grand'Maison, Francois, Duquette, Pierre, Lugaresi, Alessandra, Grammond, Pierre, Boz, Cavit, Hupperts, Raymond, Petersen, Thor, Giuliani, Giorgio, Oreja-Guevara, Celia, Iuliano, Gerardo, Lechner-Scott, Jeannette, Bergamaschi, Roberto, Rio, Maria Edite, Verheul, Freek, Fiol, Marcela, Van Pesch, Vincent, Slee, Mark, Butzkueven, Helmut, and Herbert, Joseph

Abstract

The more recent MSBase enrollees in each of the mild-to-moderate disability strata were significantly older than earlier enrollees. Possible explanations for this phenomenon are discussed.

Published
2012

10. Increasing age at disability milestones among MS patients in the MSBase Registry

Author

Kister, Ilya, primary, Chamot, Eric, additional, Cutter, Gary, additional, Bacon, Tamar E., additional, Jokubaitis, Vilija G., additional, Hughes, Stella E., additional, Gray, Orla M., additional, Trojano, Maria, additional, Izquierdo, Guillermo, additional, Grand'Maison, Francois, additional, Duquette, Pierre, additional, Lugaresi, Alessandra, additional, Grammond, Pierre, additional, Boz, Cavit, additional, Hupperts, Raymond, additional, Petersen, Thor, additional, Giuliani, Giorgio, additional, Oreja-Guevara, Celia, additional, Iuliano, Gerardo, additional, Lechner-Scott, Jeannette, additional, Bergamaschi, Roberto, additional, Rio, Maria Edite, additional, Verheul, Freek, additional, Fiol, Marcela, additional, Van Pesch, Vincent, additional, Slee, Mark, additional, Butzkueven, Helmut, additional, and Herbert, Joseph, additional

Published
2012
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11. Predictors and dynamics of postpartum relapses in women with multiple sclerosis.

Author

Hughes, Stella E, Spelman, Tim, Gray, Orla M, Boz, Cavit, Trojano, Maria, Lugaresi, Alessandra, Izquierdo, Guillermo, Duquette, Pierre, Girard, Marc, Grand’Maison, Francois, Grammond, Pierre, Oreja-Guevara, Celia, Hupperts, Raymond, Bergamaschi, Roberto, Giuliani, Giorgio, Lechner-Scott, Jeannette, Barnett, Michael, Edite Rio, Maria, van Pesch, Vincent, and Amato, Maria Pia

Subjects
*PREGNANCY complications, *POSTPARTUM depression, *MULTIPLE sclerosis, *DISEASE relapse, *DISEASES in women
Abstract

The article focuses on the study which discusses the effect of pregnancy and postpartum relapses in women with multiple sclerosis (MS) using large international MSBase Registry. It states the observational case-control study performed on pregnancies post-MS. It mentions the favorable effect on relapses as the pregnancy proceeds and peak of early postpartum.

Published
2014
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12. Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis: An International Registry Study.

Author

Vitkova M, Diouf I, Malpas C, Horakova D, Kubala Havrdova E, Patti F, Ozakbas S, Izquierdo G, Eichau S, Shaygannejad V, Onofrj M, Lugaresi A, Alroughani R, Prat A, Larochelle C, Girard M, Duquette P, Terzi M, Boz C, Grand'Maison F, Sola P, Ferraro D, Grammond P, Butzkueven H, Buzzard K, Skibina O, Yamout BI, Karabudak R, Gerlach O, Lechner-Scott J, Maimone D, Bergamaschi R, Van Pesch V, Iuliano G, Cartechini E, José Sà M, Ampapa R, Barnett M, Hughes SE, Ramo-Tello CM, Hodgkinson S, Spitaleri DLA, Petersen T, Butler EG, Slee M, McGuigan C, McCombe PA, Granella F, Cristiano E, Prevost J, Taylor BV, Sãnchez-Menoyo JL, Laureys G, Van Hijfte L, Vucic S, Macdonell RA, Gray O, Olascoaga J, Deri N, Fragoso YD, Shaw C, and Kalincik T

Subjects
Disability Evaluation, Female, Humans, Male, Registries, Severity of Illness Index, Ultraviolet Rays adverse effects, Multiple Sclerosis diagnosis, Multiple Sclerosis epidemiology
Abstract

Background and Objectives: The severity of multiple sclerosis (MS) varies widely among individuals. Understanding the determinants of this heterogeneity will help clinicians optimize the management of MS. The aim of this study was to investigate the association between latitude of residence, UV B radiation (UVB) exposure, and the severity of MS., Methods: This observational study used the MSBase registry data. The included patients met the 2005 or 2010 McDonald diagnostic criteria for MS and had a minimum dataset recorded in the registry (date of birth, sex, clinic location, date of MS symptom onset, disease phenotype at baseline and censoring, and ≥1 Expanded Disability Status Scale score recorded). The latitude of each study center and cumulative annualized UVB dose at study center (calculated from National Aeronautics and Space Administration's Total Ozone Mapping Spectrometer) at ages 6 and 18 years and the year of disability assessment were calculated. Disease severity was quantified with Multiple Sclerosis Severity Score (MSSS). Quadratic regression was used to model the associations between latitude, UVB, and MSSS., Results: The 46,128 patients who contributed 453,208 visits and a cumulative follow-up of 351,196 patient-years (70% women, mean age 39.2 ± 12 years, resident between latitudes 19°35' and 56°16') were included in this study. Latitude showed a nonlinear association with MS severity. In latitudes <40°, more severe disease was associated with higher latitudes (β = 0.08, 95% CI 0.04-0.12). For example, this translates into a mean difference of 1.3 points of MSSS between patients living in Madrid and Copenhagen. No such association was observed in latitudes <40° (β = -0.02, 95% CI -0.06 to 0.03). The overall disability accrual was faster in those with a lower level of estimated UVB exposure before the age of 6 years (β = - 0.5, 95% CI -0.6 to 0.4) and 18 years (β = - 0.6, 95% CI -0.7 to 0.4), as well as with lower lifetime UVB exposure at the time of disability assessment (β = -1.0, 95% CI -1.1 to 0.9)., Discussion: In temperate zones, MS severity is associated with latitude. This association is mainly, but not exclusively, driven by UVB exposure contributing to both MS susceptibility and severity., (© 2022 American Academy of Neurology.)

Published
2022
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