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229 results on '"Hughes, G.R.V."'

1. Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicentre prospective study of 1000 patients

Author

Cervera, R., Khamashta, M.A., Shoenfeld, Y., Camps, M.T., Jacobsen, S., Kiss, E., Zeher, M.M., Tincani, A., Kontopoulou-Griva, I., Galeazzi, M., Bellisai, F., Meroni, P.L., Derksen, R.H.W.M., de Groot, P.G., Gromnica-Ihle, E., Baleva, M., Mosca, M., Bombardieri, S., Houssiau, F., Gris, J.-C., Quere, I., Hachulla, E., Vasconcelos, C., Roch, B., Fernandez-Nebro, A., Piette, J.-C., Espinosa, G., Bucciarelli, S., Pisoni, C.N., Bertolaccini, M.L., Boffa, M.-C., and Hughes, G.R.V.

Subjects
Antiphospholipid syndrome -- Patient outcomes, Antiphospholipid syndrome -- Demographic aspects, Antiphospholipid syndrome -- Research, Morbidity -- Demographic aspects, Morbidity -- Research, Mortality -- Demographic aspects, Mortality -- Research, Health
Published
2009

2. Antiphospholipid antibody tests: spreading the net

Author

Bertolaccini, M.L., Gomez, S., Pareja, J.F.P., Theodoridou, A., Sanna, G., Hughes, G.R.V., and Khamashta, M.A.

Subjects
Systemic lupus erythematosus -- Diagnosis, Blood clot -- Diagnosis, Thrombosis -- Diagnosis, Antiphospholipid antibodies -- Analysis, Antiphospholipid antibodies -- Usage, Health
Published
2005

11. Migraine, memory loss, and 'multiple sclerosis'. Neurological features of the antiphospholipid (Hughes') syndrome. (Review)

Author

Hughes, G.R.V.

Subjects
Stroke (Disease) -- Causes of -- Health aspects -- Complications and side effects -- Care and treatment -- Case studies -- Analysis, Medical research -- Analysis -- Case studies -- Health aspects, Medicine, Experimental -- Analysis -- Case studies -- Health aspects, Antiphospholipid syndrome -- Case studies -- Care and treatment -- Health aspects -- Complications and side effects -- Analysis, Neurologic examination -- Analysis -- Case studies -- Health aspects, Headache -- Causes of -- Health aspects -- Complications and side effects -- Care and treatment -- Case studies -- Analysis, Ischemia -- Health aspects -- Causes of -- Case studies -- Complications and side effects -- Care and treatment -- Analysis, Health
Abstract

The antiphospholipid syndrome (APS, Hughes' syndrome), first described in 1983, is a prothrombotic disease in which neurological events feature prominently. Strokes, transient ischaemic attacks, and headaches (including migraine) are important [...]

Published
2003

13. Anticardiolipin antibodies in patients from Malaysia with systemic lupus erythematosus

Author

Jones, H.W., Ireland, R., Senaldi, G., Wang, F., Khamashta, M., Bellingham, A.J., Veerapan, K., Hughes, G.R.V., and Vergani, D.

Subjects
Autoantibodies -- Measurement, Systemic lupus erythematosus -- Malaysia, Autoimmune diseases -- Demographic aspects, Health
Abstract

Rheumatic diseases like systemic lupus erythematosus (SLE) are characterized by elevated blood levels of autoantibodies, which recognize and attack the body's own molecules. One particular molecule recognized by autoantibodies is cardiolipin, a phosphate-containing fatty compound which is present in the membranes that surround cells. Anti-cardiolipin antibodies (aCLs) in patients with SLE have been associated with thrombosis (clot formation), nervous system disease, miscarriage, and thrombocytopenia (low levels of platelets, which are important for blood clotting). It turns out that SLE is more often found in Malaysians of Chinese ancestry than in those with Malay or Indian ancestry. To determine whether there were differences in aCL levels in SLE patients of different ethnic heritage, blood concentrations of aCL were measured in 200 patients (174 female) of whom 164 were Chinese, 26 Malay, and 10 Indian. The results were compared with those from 103 healthy subjects. Of 114 patients from whom medical details were available, joint and skin involvement was present in 95 percent, while the kidney was involved in 71 percent, a relatively high amount. Raised aCL levels were present in 16.5 percent of patients. Levels significantly correlated with age in both patients and healthy subjects, and were inversely related to platelet levels. The prevalence of elevated aCL did not differ among ethnic groups, nor did levels relate to involvement of particular organs. The study indicates that elevated aCL and thrombosis occur infrequently in SLE patients in Malaysia. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

14. Association of HLA-DM polymorphism with the production of antiphospholipid antibodies

Author

Sanchez, M.L., Katsumata, K., Atsumi, T., Romero, F.I., Bertolaccini, M.L., Funke, A., Amengual, O., Kondeatis, E., Vaughan, R.W., Cox, A., Hughes, G.R.V., and Khamashta, M.A.

Subjects
HLA class II antigens -- Alliances and partnerships, HLA class II antigens -- Research, Antiphospholipid antibodies -- Alliances and partnerships, Antiphospholipid antibodies -- Research, Health
Published
2004

15. The point prevalence of an abnormal ankle-brachial index in antiphospholipid antibody negative patients with livedo reticularis: a controlled study

Author

Sangle, S., Christodoulou, C., Paul, S., Hughes, G.R.V., and D'Cruz, D.P.

Subjects
Pigmentation disorders -- Development and progression, Antiphospholipid antibodies -- Physiological aspects, Ankle -- Physiological aspects, Ankle -- Medical examination, Brachial artery -- Physiological aspects, Brachial artery -- Medical examination, Blood pressure -- Measurement, Blood pressure -- Analysis, Health
Published
2008

17. Prevalence of an abnormal ankle-brachial index in patients with antiphospholipid syndrome with pregnancy loss but without thrombosis: a controlled study

Author

Christodoulou, C., Zain, M., Bertolaccini, M.L., Sangle, S., Khamashta, M.A., Hughes, G.R.V., and D'Cruz, D.P.

Subjects
Antiphospholipid syndrome -- Research, Antiphospholipid syndrome -- Physiological aspects, Pregnant women -- Research, Pregnant women -- Physiological aspects, Pregnant women -- Complications and side effects, Atherosclerosis -- Diagnosis, Antiphospholipid antibodies -- Research, Antiphospholipid antibodies -- Physiological aspects, Health
Published
2006

25. Syndrome des anticorps antiphospholipides : caractéristiques cliniques et biologiques de 1 000 patients (euro-phospholipid project)

Author

Cervera, R., primary, Gris, J.C., additional, Hachulla, E., additional, Quéré, I., additional, Khamashta, M.A., additional, de Ramon, E., additional, Espinosa, G., additional, Testi, A., additional, Ramos-Casals, M., additional, Garcia-Carrasco, M., additional, Munoz, F.J., additional, Sena, F., additional, Ingelmo, M., additional, Bertolaccini, L., additional, Camps, M.T., additional, Font, J., additional, Shoenfeld, Y., additional, Boffa, M.C., additional, Hughes, G.R.V., additional, and Piette, J.C., additional

Published
2000
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27. Reassessing the status of antiphospholipid syndrome in systemic lupus erythematosus

Author

Vianna, Joao L., Haga, Hans J., Tripathi, Poonam, Cervera, Ricard, Khamashta, Munther A., and Hughes, G.R.V.

Subjects
Antiphospholipid syndrome -- Physiological aspects, Systemic lupus erythematosus -- Physiological aspects, Thrombosis -- Risk factors, Anticardiolipin antibodies -- Health aspects, Health
Published
1992

48. Antibodies to endothelial cells in primary vasculitides mediate in vitro endothelial cytotoxicity in the presence of normal peripheral blood mononuclear cells

Author

Del Papa, N., primary, Meroni, P.L., additional, Barcellini, W., additional, Sinico, A., additional, Radice, A., additional, Tincani, T., additional, D'Cruz, D., additional, Nicoletti, F., additional, Borghi, M.O., additional, Khamashita, M.A., additional, Hughes, G.R.V., additional, and Balestrieri, G., additional

Published
1992
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