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1. Researching COVID to enhance recovery (RECOVER) adult study protocol: Rationale, objectives, and design

Author

Horwitz, Leora I, Thaweethai, Tanayott, Brosnahan, Shari B, Cicek, Mine S, Fitzgerald, Megan L, Goldman, Jason D, Hess, Rachel, Hodder, SL, Jacoby, Vanessa L, Jordan, Michael R, Krishnan, Jerry A, Laiyemo, Adeyinka O, Metz, Torri D, Nichols, Lauren, Patzer, Rachel E, Sekar, Anisha, Singer, Nora G, Stiles, Lauren E, Taylor, Barbara S, Ahmed, Shifa, Algren, Heather A, Anglin, Khamal, Aponte-Soto, Lisa, Ashktorab, Hassan, Bassett, Ingrid V, Bedi, Brahmchetna, Bhadelia, Nahid, Bime, Christian, Bind, Marie-Abele C, Black, Lora J, Blomkalns, Andra L, Brim, Hassan, Castro, Mario, Chan, James, Charney, Alexander W, Chen, Benjamin K, Chen, Li Qing, Chen, Peter, Chestek, David, Chibnik, Lori B, Chow, Dominic C, Chu, Helen Y, Clifton, Rebecca G, Collins, Shelby, Costantine, Maged M, Cribbs, Sushma K, Deeks, Steven G, Dickinson, John D, Donohue, Sarah E, Durstenfeld, Matthew S, Emery, Ivette F, Erlandson, Kristine M, Facelli, Julio C, Farah-Abraham, Rachael, Finn, Aloke V, Fischer, Melinda S, Flaherman, Valerie J, Fleurimont, Judes, Fonseca, Vivian, Gallagher, Emily J, Gander, Jennifer C, Gennaro, Maria Laura, Gibson, Kelly S, Go, Minjoung, Goodman, Steven N, Granger, Joey P, Greenway, Frank L, Hafner, John W, Han, Jenny E, Harkins, Michelle S, Hauser, Kristine SP, Heath, James R, Hernandez, Carla R, Ho, On, Hoffman, Matthew K, Hoover, Susan E, Horowitz, Carol R, Hsu, Harvey, Hsue, Priscilla Y, Hughes, Brenna L, Jagannathan, Prasanna, James, Judith A, John, Janice, Jolley, Sarah, Judd, SE, Juskowich, Joy J, Kanjilal, Diane G, Karlson, Elizabeth W, Katz, Stuart D, Kelly, J Daniel, Kelly, Sara W, Kim, Arthur Y, Kirwan, John P, Knox, Kenneth S, Kumar, Andre, Lamendola-Essel, Michelle F, Lanca, Margaret, Lee-lannotti, Joyce K, Lefebvre, R Craig, and Levy, Bruce D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Clinical Research, Emerging Infectious Diseases, Infectious Diseases, Infection, Good Health and Well Being
Abstract

Abstract: Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis. Methods: RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged ≥18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility– and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross– validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms. Discussion: RECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options.

Published
2023

2. Universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Testing for Obstetric Inpatient Units Across the United States

Author

Gilner, Jennifer, Kansal, Namita, Biggio, Joseph R, Delaney, Shani, Grotegut, Chad A, Hardy, Erica, Hirshberg, Adi, Kachikis, Alisa, LaCourse, Sylvia M, Martin, Jane, Metz, Torri D, Miller, Emily S, Norton, Mary E, Sinkey, Rachel, Sobhani, Nasim C, Son, Shannon L, Srinivas, Sindhu, Tita, Alan, Werner, Erika F, and Hughes, Brenna L

Subjects
Vaccine Related, Biodefense, Infectious Diseases, Pneumonia & Influenza, Prevention, Lung, Clinical Trials and Supportive Activities, Pneumonia, Health Services, Clinical Research, Emerging Infectious Diseases, Good Health and Well Being, COVID-19, COVID-19 Testing, Clinical Laboratory Techniques, Cross-Sectional Studies, Female, Humans, Inpatients, Pregnancy, Pregnancy Complications, Infectious, SARS-CoV-2, United States, pregnancy, testing, screening, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundThe purpose of this study was to estimate prevalence of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among patients admitted to obstetric inpatient units throughout the United States as detected by universal screening. We sought to describe the relationship between obstetric inpatient asymptomatic infection rates and publicly available surrounding community infection rates.MethodsA cross-sectional study in which medical centers reported rates of positive SARS-CoV-2 testing in asymptomatic pregnant and immediate postpartum patients over a 1-3-month time span in 2020. Publicly reported SARS-CoV-2 case rates from the relevant county and state for each center were collected from the COVID Act Now dashboard and the COVID Tracking Project for correlation analysis.ResultsData were collected from 9 health centers, encompassing 18 hospitals. Participating health centers were located in Alabama, California, Illinois, Louisiana, New Jersey, North Carolina, Pennsylvania, Rhode Island, Utah, and Washington State. Each hospital had an active policy for universal SARS-CoV-2 testing on obstetric inpatient units. A total of 10 147 SARS-CoV-2 tests were administered, of which 124 were positive (1.2%). Positivity rates varied by site, ranging from 0-3.2%. While SARS-CoV-2 infection rates were lower in asymptomatic obstetric inpatient groups than the surrounding communities, there was a positive correlation between positivity rates in obstetric inpatient units and their surrounding county (P=.003, r=.782) and state (P=.007, r=.708).ConclusionsGiven the correlation between community and obstetric inpatient rates, the necessity of SARS-CoV-2-related healthcare resource utilization in obstetric inpatient units may be best informed by surrounding community infection rates.

Published
2022

4. Treatment for Mild Chronic Hypertension during Pregnancy

Author

Tita, Alan T, Szychowski, Jeff M, Boggess, Kim, Dugoff, Lorraine, Sibai, Baha, Lawrence, Kirsten, Hughes, Brenna L, Bell, Joseph, Aagaard, Kjersti, Edwards, Rodney K, Gibson, Kelly, Haas, David M, Plante, Lauren, Metz, Torri, Casey, Brian, Esplin, Sean, Longo, Sherri, Hoffman, Matthew, Saade, George R, Hoppe, Kara K, Foroutan, Janelle, Tuuli, Methodius, Owens, Michelle Y, Simhan, Hyagriv N, Frey, Heather, Rosen, Todd, Palatnik, Anna, Baker, Susan, August, Phyllis, Reddy, Uma M, Kinzler, Wendy, Su, Emily, Krishna, Iris, Nguyen, Nicki, Norton, Mary E, Skupski, Daniel, El-Sayed, Yasser Y, Ogunyemi, Dotum, Galis, Zorina S, Harper, Lorie, Ambalavanan, Namasivayam, Geller, Nancy L, Oparil, Suzanne, Cutter, Gary R, and Andrews, William W

Subjects
Paediatrics, Reproductive Medicine, Biomedical and Clinical Sciences, Lung, Clinical Trials and Supportive Activities, Hypertension, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Infant Mortality, Contraception/Reproduction, Cardiovascular, Patient Safety, Pediatric, Conditions Affecting the Embryonic and Fetal Periods, Perinatal Period - Conditions Originating in Perinatal Period, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Reproductive health and childbirth, Good Health and Well Being, Abruptio Placentae, Antihypertensive Agents, Birth Weight, Chronic Disease, Female, Fetal Growth Retardation, Humans, Hypertension, Pregnancy-Induced, Infant, Newborn, Pre-Eclampsia, Pregnancy, Pregnancy Outcome, Premature Birth, Chronic Hypertension and Pregnancy (CHAP) Trial Consortium, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThe benefits and safety of the treatment of mild chronic hypertension (blood pressure,

Published
2022

6. Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19

Author

Kuriakose, Safia, Singh, Kanal, Pau, Alice K, Daar, Eric, Gandhi, Rajesh, Tebas, Pablo, Evans, Laura, Gulick, Roy M, Lane, H Clifford, Masur, Henry, Aberg, Judith A, Adimora, Adaora A, Baker, Jason, Kreuziger, Lisa Baumann, Bedimo, Roger, Belperio, Pamela S, Cantrill, Stephen V, Coopersmith, Craig M, Davis, Susan L, Dzierba, Amy L, Gallagher, John J, Glidden, David V, Grund, Birgit, Hardy, Erica J, Hinkson, Carl, Hughes, Brenna L, Johnson, Steven, Keller, Marla J, Kim, Arthur Y, Lennox, Jeffrey L, Levy, Mitchell M, Li, Jonathan Z, Martin, Greg S, Naggie, Susanna, Pavia, Andrew T, Seam, Nitin, Simpson, Steven Q, Swindells, Susan, Tien, Phyllis, Waghmare, Alpana A, Wilson, Kevin C, Yazdany, Jinoos, Zachariah, Philip, Campbell, Danielle M, Harrison, Carly, Burgess, Timothy, Francis, Joseph, Sheikh, Virginia, Uyeki, Timothy M, Walker, Robert, Brooks, John T, Ortiz, Laura Bosque, Davey, Richard T, Doepel, Laurie K, Eisinger, Robert W, Han, Alison, Higgs, Elizabeth S, Nason, Martha C, Crew, Page, Lerner, Andrea M, Lund, Claire, and Worthington, Christopher

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Services, Clinical Research, Generic health relevance, Good Health and Well Being, Advisory Committees, COVID-19, Child, Data Interpretation, Statistical, Drug Approval, Evidence-Based Medicine, Female, Humans, Interprofessional Relations, National Institutes of Health (U.S.), Pandemics, Practice Guidelines as Topic, Pregnancy, SARS-CoV-2, Stakeholder Participation, United States, COVID-19 Drug Treatment, NIH COVID-19 Treatment Guidelines Panel, Medical and Health Sciences, General & Internal Medicine, Clinical sciences
Abstract

The development of the National Institutes of Health (NIH) COVID-19 Treatment Guidelines began in March 2020 in response to a request from the White House Coronavirus Task Force. Within 4 days of the request, the NIH COVID-19 Treatment Guidelines Panel was established and the first meeting took place (virtually-as did subsequent meetings). The Panel comprises 57 individuals representing 6 governmental agencies, 11 professional societies, and 33 medical centers, plus 2 community members, who have worked together to create and frequently update the guidelines on the basis of evidence from the most recent clinical studies available. The initial version of the guidelines was completed within 2 weeks and posted online on 21 April 2020. Initially, sparse evidence was available to guide COVID-19 treatment recommendations. However, treatment data rapidly accrued based on results from clinical studies that used various study designs and evaluated different therapeutic agents and approaches. Data have continued to evolve at a rapid pace, leading to 24 revisions and updates of the guidelines in the first year. This process has provided important lessons for responding to an unprecedented public health emergency: Providers and stakeholders are eager to access credible, current treatment guidelines; governmental agencies, professional societies, and health care leaders can work together effectively and expeditiously; panelists from various disciplines, including biostatistics, are important for quickly developing well-informed recommendations; well-powered randomized clinical trials continue to provide the most compelling evidence to guide treatment recommendations; treatment recommendations need to be developed in a confidential setting free from external pressures; development of a user-friendly, web-based format for communicating with health care providers requires substantial administrative support; and frequent updates are necessary as clinical evidence rapidly emerges.

Published
2021

7. Breastfeeding initiation and duration among people with mild chronic hypertension: a secondary analysis of the Chronic Hypertension and Pregnancy trial

Author

Goulding, Alison N., Antoniewicz, Leah, Leach, Justin M., Boggess, Kim, Dugoff, Lorraine, Sibai, Baha, Lawrence, Kirsten, Hughes, Brenna L., Bell, Joseph, Edwards, Rodney K., Gibson, Kelly, Haas, David M., Plante, Lauren, Metz, Torri D., Casey, Brian, Esplin, Sean, Longo, Sherri, Hoffman, Matthew, Saade, George R., Hoppe, Kara K., Foroutan, Janelle, Tuuli, Methodius, Owens, Michelle Y., Simhan, Hyagriv N., Frey, Heather, Rosen, Todd, Palatnik, Anna, Baker, Susan, Reddy, Uma M., Kinzler, Wendy, Su, Emily, Krishna, Iris, Nguyen, Nicki, Norton, Mary E., Skupski, Daniel, El-Sayed, Yasser Y., Ogunyemi, Dotun, Harper, Lorie M., Ambalavanan, Namasivayam, Oparil, Suzanne, Szychowski, Jeff M., and Tita, Alan T.

Published
2023
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11. Mean Arterial Pressure and Neonatal Outcomes in Pregnancies Complicated by Mild Chronic Hypertension

Author

Moore, Matthew D., primary, Kuo, Hui-Chien, additional, Sinkey, Rachel G., additional, Boggess, Kim, additional, Dugoff, Lorraine, additional, Sibai, Baha, additional, Lawrence, Kirsten, additional, Hughes, Brenna L., additional, Bell, Joseph, additional, Aagaard, Kjersti, additional, Edwards, Rodney K., additional, Gibson, Kelly S., additional, Haas, David M., additional, Plante, Lauren, additional, Metz, Torri D., additional, Casey, Brian, additional, Esplin, Sean, additional, Longo, Sherri, additional, Hoffman, Matthew K., additional, Saade, George R., additional, Hoppe, Kara K., additional, Foroutan, Janelle, additional, Tuuli, Methodius, additional, Owens, Michelle Y., additional, Simhan, Hyagriv N., additional, Frey, Heather A., additional, Rosen, Todd, additional, Palatnik, Anna, additional, Baker, Susan, additional, August, Phyllis, additional, Reddy, Uma M., additional, Kinzler, Wendy, additional, Su, Emily J., additional, Krishna, Iris, additional, Nguyen, Nguyet A., additional, Norton, Mary E., additional, Skupski, Daniel, additional, El-Sayed, Yasser Y., additional, Ogunyemi, Dotun, additional, Librizzi, Ronald, additional, Pereira, Leonardo, additional, Magann, Everett F., additional, Habli, Mounira, additional, Williams, Shauna, additional, Mari, Giancarlo, additional, Pridjian, Gabriella, additional, McKenna, David S., additional, Parrish, Marc, additional, Chang, Eugene, additional, Osmundson, Sarah, additional, Quiñones, Joanne N., additional, Leach, Justin, additional, Sanusi, Ayodeji, additional, Galis, Zorina S., additional, Harper, Lorie, additional, Ambalavanan, Namasivayam, additional, Szychowski, Jeff M., additional, and Tita, Alan T.N., additional

Published
2024
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14. Amniocentesis to diagnose congenital cytomegalovirus infection following maternal primary infection

Author

Dinsmoor, Mara J., Fette, Lida M., Hughes, Brenna L., Rouse, Dwight J., Saade, George R., Reddy, Uma M., Allard, Donna, Mallett, Gail, Thom, Elizabeth A., Gyamfi-Bannerman, Cynthia, Varner, Michael W., Goodnight, William H., Tita, Alan T.N., Costantine, Maged M., Swamy, Geeta K., Heyborne, Kent D., Chien, Edward K., Chauhan, Suneet P., El-Sayed, Yasser Y., Casey, Brian M., Parry, Samuel, Simhan, Hyagriv N., Napolitano, Peter G., and Macones, George A.

Published
2022
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17. Association Between Influenza Vaccination and SARS‐CoV‐2 Infection.

Author

Ma'ayeh, Marwan, de Voest, Jessica A., Hughes, Brenna L., Grobman, William A., Saade, George R., Manuck, Tracy A., Longo, Monica, Simhan, Hyagriv N., Rouse, Dwight J., Mendez‐Figueroa, Hector, Gyamfi‐Bannerman, Cynthia, Bailit, Jennifer L., Costantine, Maged M., Sehdev, Harish M., Tita, Alan T. N., and Metz, Torri D.

Subjects
PREGNANT women, INFLUENZA vaccines, PREGNANCY outcomes, TOBACCO smoke, SMOKING
Abstract

Background: Recent data in nonpregnant individuals suggest a protective effect of influenza vaccination against SARS‐CoV‐2 infection and its severity. Objectives: Our primary objective was to evaluate whether influenza vaccination was associated with COVID‐19 severity and pregnancy and neonatal outcomes among those infected with SARS‐CoV‐2. The secondary objective was to examine the association between influenza vaccination and SARS‐CoV‐2 infection. Study Design: Secondary analysis of a multicenter retrospective cohort of pregnant people who tested positive for SARS‐CoV‐2 between March and August 2020, and a cohort of random deliveries during the same time period. The associations between 2019 influenza vaccination and the primary outcome of moderate‐to‐critical COVID‐19 as well as maternal and perinatal outcomes were examined among all people who tested positive for SARS‐CoV‐2 between March and August 2020. The association between 2019 influenza vaccination and having a positive SARS‐CoV‐2 test was examined among a cohort of individuals who delivered on randomly selected dates between March and August 2020. Univariable and multivariable analyses were performed. Results: Of 2325 people who tested positive for SARS‐CoV‐2, 1068 (45.9%) were vaccinated against influenza in 2019. Those who received the influenza vaccine were older, leaner, more likely to have private insurance, and identify as White or Hispanic. They were less likely to smoke tobacco and identify as Black. Overall, 419 (18.0%) had moderate, 193 (8.3%) severe, and 52 (2.2%) critical COVID‐19. There was no association between influenza vaccination and moderate‐to‐critical COVID‐19 (29.2% vs. 28.0%, adjusted OR 1.10, 95% CI 0.90–1.34) or adverse maternal and perinatal outcomes among those who tested positive. Of 8152 people who delivered in 2020, 4658 (57.1%) received the influenza vaccine. Prior vaccination was not associated with a difference in the odds of SARS‐CoV‐2 infection (3.8% vs. 4.2%, adjusted OR 0.94, 95% CI 0.74–1.19). Conclusion: Prior influenza vaccination was not associated with decreased severity of COVID‐19 or lower odds of SARS‐CoV‐2 infection in pregnancy. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Treatment for Mild Chronic Hypertension During Pregnancy

Author

Tita, Alan T., Szychowski, Jeff M., Boggess, Kim, Dugoff, Lorraine, Sibai, Baha, Lawrence, Kirsten, Hughes, Brenna L., Bell, Joseph, Aagaard, Kjersti, Edwards, Rodney K., Gibson, Kelly, Haas, David M., Plante, Lauren, Metz, Torri, Casey, Brian, Esplin, Sean, Longo, Sherri, Hoffman, Matthew, Saade, George R., Hoppe, Kara K., Foroutan, Janelle, Tuuli, Methodius, Owens, Michelle Y., Simhan, Hyagriv N., Frey, Heather, Rosen, Todd, Palatnik, Anna, Baker, Susan, August, Phyllis, Reddy, Uma M., Kinzler, Wendy, Su, Emily, Krishna, Iris, Nguyen, Nicki, Norton, Mary E., Skupski, Daniel, El-Sayed, Yasser Y., Ogunyemi, Dotum, Galis, Zorina S., Harper, Lorie, Ambalavanan, Namasivayam, Geller, Nancy L., Oparil, Suzanne, Cutter, Gary R., and Andrews, William W.

Published
2022
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21. Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications

Author

Metz, Torri D., Clifton, Rebecca G., Hughes, Brenna L., Sandoval, Grecio J., Grobman, William A., Saade, George R., Manuck, Tracy A., Longo, Monica, Sowles, Amber, Clark, Kelly, Simhan, Hyagriv N., Rouse, Dwight J., Mendez-Figueroa, Hector, Gyamfi-Bannerman, Cynthia, Bailit, Jennifer L., Costantine, Maged M., Sehdev, Harish M., Tita, Alan T. N., and Macones, George A.

Published
2022
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22. Understanding New Recommendations for Respiratory Syncytial Virus Prevention in Pregnancy.

Author

Horgan, Rebecca, Hughes, Brenna L., Waller, Jerri, Hage Diab, Yara, and Saade, George

Abstract

A vaccination against respiratory syncytial virus (RSV) was approved by the U.S. Food and Drug Administration recently and is now recommended during pregnancy at 32–36 weeks of gestation for patients who will deliver during RSV season if the infant is not anticipated to receive nirsevimab. Respiratory syncytial virus (RSV) is a significant cause of infant morbidity and mortality worldwide with peak hospitalization rates for RSV-mediated illnesses between 2 and 3 months of life. Until very recently, prevention strategies for RSV involved primarily passive immunization of neonates at high risk with monoclonal antibodies and promotion of breastfeeding. The Centers for Disease Control and Prevention's (CDC) Advisory Committee on Immunization Practices now recommends passive immunization of all neonates with monoclonal antibodies during RSV season, and the American Association of Pediatrics has endorsed this practice. The U.S. Food and Drug Administration (FDA) recently approved a vaccination for RSV in pregnancy. The CDC's Advisory Committee on Immunization Practices has recently recommended RSV vaccination for all pregnant patients between 32 and 36 weeks of gestation who are anticipated to deliver during RSV season if they are not planning nirsevimab for their infants. This recommendation has been endorsed by the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine. In this clinical perspective, we review the scientific evidence, potential concerns, challenges, and future considerations for RSV vaccination in pregnancy. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Performance Characteristics of Sepsis Screening Tools During Delivery Admissions

Author

Main, Elliott K., primary, Fuller, Matt, additional, Kovacheva, Vesela P., additional, Elkhateb, Rania, additional, Azar, Kristen, additional, Caldwell, Morgan, additional, Chiem, Vanna, additional, Foster, Mindy, additional, Gibbs, Ronald, additional, Hughes, Brenna L., additional, Johnson, Rebecca, additional, Kottukapally, Nobin, additional, Cortes, Magdalena Sanz, additional, Rosenstein, Melissa G., additional, Shields, Laurence E., additional, Sudat, Sylvia, additional, Sutton, Caitlin D., additional, Toledo, Paloma, additional, Traylor, Austin, additional, Wharton, Kurt, additional, and Bauer, Melissa E., additional

Published
2023
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26. Performance Characteristics of Sepsis Screening Tools During Antepartum and Postpartum Admissions

Author

Bauer, Melissa E., primary, Fuller, Matt, additional, Kovacheva, Vesela, additional, Elkhateb, Rania, additional, Azar, Kristen, additional, Caldwell, Morgan, additional, Chiem, Vanna, additional, Foster, Mindy, additional, Gibbs, Ronald, additional, Hughes, Brenna L., additional, Johnson, Rebecca, additional, Kottukapally, Nobin, additional, Rosenstein, Melissa G., additional, Cortes, Magdalena Sanz, additional, Shields, Laurence E., additional, Sudat, Sylvia, additional, Sutton, Caitlin D., additional, Toledo, Paloma, additional, Traylor, Austin, additional, Wharton, Kurt, additional, and Main, Elliott, additional

Published
2023
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27. Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection — 2-Year Outcomes

Author

Hughes, Brenna L., primary, Clifton, Rebecca G., additional, Rouse, Dwight J., additional, Saade, George R., additional, Dinsmoor, Mara J., additional, Reddy, Uma M., additional, Pass, Robert, additional, Allard, Donna, additional, Mallett, Gail, additional, MacPherson, Cora, additional, Wapner, Ronald, additional, Metz, Torri, additional, Goodnight, William H., additional, Tita, Alan T.N., additional, Costantine, Maged M., additional, Swamy, Geeta K., additional, Heyborne, Kent D., additional, Chien, Edward K., additional, Chauhan, Suneet P., additional, El-Sayed, Yasser Y., additional, Casey, Brian M., additional, Parry, Samuel, additional, Simhan, Hyagriv N., additional, Napolitano, Peter G., additional, and Macones, George A., additional

Published
2023
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30. First- or second-trimester SARS-CoV-2 infection and subsequent pregnancy outcomes

Author

Hughes, Brenna L., Sandoval, Grecio J., Metz, Torri D., Clifton, Rebecca G., Grobman, William A., Saade, George R., Manuck, Tracy A., Longo, Monica, Sowles, Amber, Clark, Kelly, Simhan, Hyagriv N., Rouse, Dwight J., Mendez-Figueroa, Hector, Gyamfi-Bannerman, Cynthia, Bailit, Jennifer, Costantine, Maged M., Sehdev, Harish M., Tita, Alan T.N., and Macones, George A.

Published
2023
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31. Noninvasive Prediction of Congenital Cytomegalovirus Infection After Maternal Primary Infection

Author

Rouse, Dwight J., Fette, Lida M., Hughes, Brenna L., Saade, George R., Dinsmoor, Mara J., Reddy, Uma M., Pass, Robert, Allard, Donna, Mallett, Gail, Clifton, Rebecca G., Saccoccio, Frances M., Permar, Sallie R., Gyamfi-Bannerman, Cynthia, Varner, Michael W., Goodnight, William H., Tita, Alan T. N., Costantine, Maged M., Swamy, Geeta K., Heyborne, Kent D., Chien, Edward K., Chauhan, Suneet P., El-Sayed, Yasser Y., Casey, Brian M., Parry, Samuel, Simhan, Hyagriv N., Napolitano, Peter G., and Macones, George A.

Published
2022
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33. A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection

Author

Hughes, Brenna L., Clifton, Rebecca G., Rouse, Dwight J., Saade, George R., Dinsmoor, Mara J., Reddy, Uma M., Pass, Robert, Allard, Donna, Mallett, Gail, Fette, Lida M., Gyamfi-Bannerman, Cynthia, Varner, Michael W., Goodnight, William H., Tita, Alan T. N., Costantine, Maged M., Swamy, Geeta K., Gibbs, Ronald S., Chien, Edward K., Chauhan, Suneet P., El-Sayed, Yasser Y., Casey, Brian M., Parry, Samuel, Simhan, Hyagriv N., Napolitano, Peter G., and Macones, George A.

Published
2022
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35. Breastfeeding Initiation, Duration, and Associated Factors Among People With Hepatitis C Virus Infection.

Author

Grasch, Jennifer L., de Voest, Jessica A., Saade, George R., Hughes, Brenna L., Reddy, Uma M., Costantine, Maged M., Chien, Edward K., Tita, Alan T.N., Thorp Jr, John M., Metz, Torri D., Wapner, Ronald J., Sabharwal, Vishakha, Simhan, Hyagriv N., Swamy, Geeta K., Heyborne, Kent D., Sibai, Baha M., Grobman, William A., El-Sayed, Yasser Y., Casey, Brian M., and Parry, Samuel

Published
2024
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36. Performance Characteristics of Sepsis Screening Tools During Antepartum and Postpartum Admissions.

Author

Bauer, Melissa E., Fuller, Matt, Kovacheva, Vesela, Elkhateb, Rania, Azar, Kristen, Caldwell, Morgan, Chiem, Vanna, Foster, Mindy, Gibbs, Ronald, Hughes, Brenna L., Johnson, Rebecca, Kottukapally, Nobin, Rosenstein, Melissa G., Cortes, Magdalena Sanz, Shields, Laurence E., Sudat, Sylvia, Sutton, Caitlin D., Toledo, Paloma, Traylor, Austin, and Wharton, Kurt

Published
2024
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37. Performance Characteristics of Sepsis Screening Tools During Delivery Admissions.

Author

Main, Elliott K., Fuller, Matt, Kovacheva, Vesela P., Elkhateb, Rania, Azar, Kristen, Caldwell, Morgan, Chiem, Vanna, Foster, Mindy, Gibbs, Ronald, Hughes, Brenna L., Johnson, Rebecca, Kottukapally, Nobin, Cortes, Magdalena Sanz, Rosenstein, Melissa G., Shields, Laurence E., Sudat, Sylvia, Sutton, Caitlin D., Toledo, Paloma, Traylor, Austin, and Wharton, Kurt

Published
2024
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38. Postpartum Pyelonephritis and Risk of Severe Maternal Morbidity.

Author

Addae-Konadu, Kateena L., Wein, Lauren E., Federspiel, Jerome J., Hughes, Brenna L., and Dotters-Katz, Sarah

Subjects
DISEASE risk factors, LENGTH of stay in hospitals, COMMUNICABLE diseases, PYELONEPHRITIS, CONFIDENCE intervals, URINARY tract infections, RETROSPECTIVE studies, DISEASES, DISEASE incidence, REGRESSION analysis, RISK assessment, SURVEYS, SEPSIS, PREGNANCY complications, PUERPERIUM, HOSPITAL care, RESEARCH funding, DELIVERY (Obstetrics), URINALYSIS, LONGITUDINAL method, MICROBIAL sensitivity tests, DISEASE complications
Abstract

Objective Pyelonephritis is the most common nonobstetric cause for hospitalization during pregnancy. The maternal and obstetric complications associated with antepartum pyelonephritis are well described. However, it is not clear whether these risks extend into the postpartum period. The primary objective of this study was to describe the morbidity associated with postpartum pyelonephritis, by comparing the morbidity associated with pyelonephritis in the postpartum period to morbidity seen during pregnancy or delivery. Study Design A retrospective cohort study was performed using the Nationwide Readmissions Database (NRD), an all-payor sample of discharges from approximately 60% of U.S. hospitalizations. Discharges between October 2015 and December 2018 were included. Maternity-associated hospitalizations, diagnosis of pyelonephritis, comorbid conditions, and incidence of severe maternal morbidity were identified using International Classification of Disease-10th Revision (ICD-10) diagnosis and procedure codes. Bivariate statistics, weighted to account for the complex survey methods in the NRD, were used to evaluate the association between antepartum, delivery, and postpartum hospital stays associated with pyelonephritis and maternal morbidity. Weighted regression models were used to evaluate the association between admission timing and maternal outcomes. Results A total of 32,850 pyelonephritis admissions were identified, corresponding to a national estimate of 61,837 admissions. Of these, 1,465 (2.4%) were postpartum, 55,056 (89.0%) were antepartum, and 5,317 (8.6%) involved a delivery stay. Rates of severe maternal morbidity were higher in the postpartum group than the antepartum or delivery hospitalization groups (59.5 vs. 12.9 and 15.8%, respectively, p < 0.001); when compared with antepartum hospitalizations, the adjusted relative risk for composite severe maternal morbidity for postpartum hospitalizations was 4.68 (95% confidence interval [CI]: 4.33, 5.05). Most of this difference was driven by rates of sepsis (53.2 vs. 11.0 vs. 10.9%). Conclusion Though relatively uncommon, postpartum hospitalizations for pyelonephritis are associated with higher rates of severe maternal morbidity, driven by differential rates of sepsis, than are antepartum or delivery-associated hospitalizations. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Perinatal Outcomes Associated With Management of Stage 1 Hypertension

Author

Bailey, Erin J., primary, Tita, Alan T. N., additional, Leach, Justin, additional, Boggess, Kim, additional, Dugoff, Lorraine, additional, Sibai, Baha, additional, Lawrence, Kirsten, additional, Hughes, Brenna L., additional, Bell, Joseph, additional, Aagaard, Kjersti, additional, Edwards, Rodney K., additional, Gibson, Kelly, additional, Haas, David M., additional, Plante, Lauren, additional, Metz, Torri D., additional, Casey, Brian M., additional, Esplin, Sean, additional, Longo, Sherri, additional, Hoffman, Matthew, additional, Saade, George R., additional, Foroutan, Janelle, additional, Tuuli, Methodius G., additional, Owens, Michelle Y., additional, Simhan, Hyagriv N., additional, Frey, Heather A., additional, Rosen, Todd, additional, Palatnik, Anna, additional, Baker, Susan, additional, August, Phyllis, additional, Reddy, Uma M., additional, Kinzler, Wendy, additional, Su, Emily J., additional, Krishna, Iris, additional, Nguyen, Nicki, additional, Norton, Mary E., additional, Skupski, Daniel, additional, El-Sayed, Yasser Y., additional, Ogunyemi, Dotun, additional, Galis, Zorina S., additional, Harper, Lorie, additional, Ambalavanan, Namasivayam, additional, Oparil, Suzanne, additional, Kuo, Hui-Chien, additional, Szychowski, Jeff M., additional, and Hoppe, Kara, additional

Published
2023
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40. Alliance for Innovation on Maternal Health

Author

Bauer, Melissa E., primary, Albright, Catherine, additional, Prabhu, Malavika, additional, Heine, R. Phillips, additional, Lennox, Chelsea, additional, Allen, Christie, additional, Burke, Carol, additional, Chavez, April, additional, Hughes, Brenna L., additional, Kendig, Susan, additional, Le Boeuf, Maile, additional, Main, Elliott, additional, Messerall, Tiffany, additional, Pacheco, Luis D., additional, Riley, Laura, additional, Solnick, Rachel, additional, Youmans, Andrew, additional, and Gibbs, Ronald, additional

Published
2023
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42. Society for Maternal-Fetal Medicine consult series #56: Hepatitis C in pregnancy: updated guidelines

Author

Dotters-Katz, Sarah K., Kuller, Effrey A., and Hughes, Brenna L.

Subjects
Pregnancy, Hepatitis C virus, Infection -- Drug therapy, Disease transmission, Resveratrol, Obstetrics, Health
Abstract

Introduction In the United States, the estimated prevalence of antenatal hepatitis C virus (HCV) infection is 1% to 4% in singlecenter studies. (1) A national multicenter prospective cohort study estimated [...]

Published
2021

43. Hepatitis C Virus Antibody Screening in a Cohort of Pregnant Women: Identifying Seroprevalence and Risk Factors

Author

Prasad, Mona, Saade, George R., Sandoval, Grecio, Hughes, Brenna L., Reddy, Uma M., Mele, Lisa, Salazar, Ashley, Varner, Michael W., Gyamfi-Bannerman, Cynthia, Thorp, John M., Jr, Tita, Alan T. N., Swamy, Geeta K., Chien, Edward K., Casey, Brian M., Peaceman, Alan M., El-Sayed, Yasser Y., Iams, Jay D., Gibbs, Ronald S., Sibai, Baha, Wiese, Nicholas, Kamili, Saleem, and Macones, George A.

Published
2020
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46. Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design

Author

Horwitz, Leora I., primary, Thaweethai, Tanayott, additional, Brosnahan, Shari B., additional, Cicek, Mine S., additional, Fitzgerald, Megan L., additional, Goldman, Jason D., additional, Hess, Rachel, additional, Hodder, S. L., additional, Jacoby, Vanessa L., additional, Jordan, Michael R., additional, Krishnan, Jerry A., additional, Laiyemo, Adeyinka O., additional, Metz, Torri D., additional, Nichols, Lauren, additional, Patzer, Rachel E., additional, Sekar, Anisha, additional, Singer, Nora G., additional, Stiles, Lauren E., additional, Taylor, Barbara S., additional, Ahmed, Shifa, additional, Algren, Heather A., additional, Anglin, Khamal, additional, Aponte-Soto, Lisa, additional, Ashktorab, Hassan, additional, Bassett, Ingrid V., additional, Bedi, Brahmchetna, additional, Bhadelia, Nahid, additional, Bime, Christian, additional, Bind, Marie-Abele C., additional, Black, Lora J., additional, Blomkalns, Andra L., additional, Brim, Hassan, additional, Castro, Mario, additional, Chan, James, additional, Charney, Alexander W., additional, Chen, Benjamin K., additional, Chen, Li Qing, additional, Chen, Peter, additional, Chestek, David, additional, Chibnik, Lori B., additional, Chow, Dominic C., additional, Chu, Helen Y., additional, Clifton, Rebecca G., additional, Collins, Shelby, additional, Costantine, Maged M., additional, Cribbs, Sushma K., additional, Deeks, Steven G., additional, Dickinson, John D., additional, Donohue, Sarah E., additional, Durstenfeld, Matthew S., additional, Emery, Ivette F., additional, Erlandson, Kristine M., additional, Facelli, Julio C., additional, Farah-Abraham, Rachael, additional, Finn, Aloke V., additional, Fischer, Melinda S., additional, Flaherman, Valerie J., additional, Fleurimont, Judes, additional, Fonseca, Vivian, additional, Gallagher, Emily J., additional, Gander, Jennifer C., additional, Gennaro, Maria Laura, additional, Gibson, Kelly S., additional, Go, Minjoung, additional, Goodman, Steven N., additional, Granger, Joey P., additional, Greenway, Frank L., additional, Hafner, John W., additional, Han, Jenny E., additional, Harkins, Michelle S., additional, Hauser, Kristine S. P., additional, Heath, James R., additional, Hernandez, Carla R., additional, Ho, On, additional, Hoffman, Matthew K., additional, Hoover, Susan E., additional, Horowitz, Carol R., additional, Hsu, Harvey, additional, Hsue, Priscilla Y., additional, Hughes, Brenna L., additional, Jagannathan, Prasanna, additional, James, Judith A., additional, John, Janice, additional, Jolley, Sarah, additional, Judd, S. E., additional, Juskowich, Joy J., additional, Kanjilal, Diane G., additional, Karlson, Elizabeth W., additional, Katz, Stuart D., additional, Kelly, J. Daniel, additional, Kelly, Sara W., additional, Kim, Arthur Y., additional, Kirwan, John P., additional, Knox, Kenneth S., additional, Kumar, Andre, additional, Lamendola-Essel, Michelle F., additional, Lanca, Margaret, additional, Lee-lannotti, Joyce K., additional, Lefebvre, R. Craig, additional, Levy, Bruce D., additional, Lin, Janet Y., additional, Logarbo, Brian P., additional, Logue, Jennifer K., additional, Longo, Michele T., additional, Luciano, Carlos A., additional, Lutrick, Karen, additional, Malakooti, Shahdi K., additional, Mallett, Gail, additional, Maranga, Gabrielle, additional, Marathe, Jai G., additional, Marconi, Vincent C., additional, Marshall, Gailen D., additional, Martin, Christopher F., additional, Martin, Jeffrey N., additional, May, Heidi T., additional, McComsey, Grace A., additional, McDonald, Dylan, additional, Mendez-Figueroa, Hector, additional, Miele, Lucio, additional, Mittleman, Murray A., additional, Mohandas, Sindhu, additional, Mouchati, Christian, additional, Mullington, Janet M., additional, Nadkarni, Girish N., additional, Nahin, Erica R., additional, Neuman, Robert B., additional, Newman, Lisa T., additional, Nguyen, Amber, additional, Nikolich, Janko Z., additional, Ofotokun, Igho, additional, Ogbogu, Princess U., additional, Palatnik, Anna, additional, Palomares, Kristy T. S., additional, Parimon, Tanyalak, additional, Parry, Samuel, additional, Parthasarathy, Sairam, additional, Patterson, Thomas F., additional, Pearman, Ann, additional, Peluso, Michael J., additional, Pemu, Priscilla, additional, Pettker, Christian M., additional, Plunkett, Beth A., additional, Pogreba-Brown, Kristen, additional, Poppas, Athena, additional, Porterfield, J. Zachary, additional, Quigley, John G., additional, Quinn, Davin K., additional, Raissy, Hengameh, additional, Rebello, Candida J., additional, Reddy, Uma M., additional, Reece, Rebecca, additional, Reeder, Harrison T., additional, Rischard, Franz P., additional, Rosas, Johana M., additional, Rosen, Clifford J., additional, Rouphael, Nadine G., additional, Rouse, Dwight J., additional, Ruff, Adam M., additional, Saint Jean, Christina, additional, Sandoval, Grecio J., additional, Santana, Jorge L., additional, Schlater, Shannon M., additional, Sciurba, Frank C., additional, Selvaggi, Caitlin, additional, Seshadri, Sudha, additional, Sesso, Howard D., additional, Shah, Dimpy P., additional, Shemesh, Eyal, additional, Sherif, Zaki A., additional, Shinnick, Daniel J., additional, Simhan, Hyagriv N., additional, Singh, Upinder, additional, Sowles, Amber, additional, Subbian, Vignesh, additional, Sun, Jun, additional, Suthar, Mehul S., additional, Teunis, Larissa J., additional, Thorp, John M., additional, Ticotsky, Amberly, additional, Tita, Alan T. N., additional, Tragus, Robin, additional, Tuttle, Katherine R., additional, Urdaneta, Alfredo E., additional, Utz, P. J., additional, VanWagoner, Timothy M., additional, Vasey, Andrew, additional, Vernon, Suzanne D., additional, Vidal, Crystal, additional, Walker, Tiffany, additional, Ward, Honorine D., additional, Warren, David E., additional, Weeks, Ryan M., additional, Weiner, Steven J., additional, Weyer, Jordan C., additional, Wheeler, Jennifer L., additional, Whiteheart, Sidney W., additional, Wiley, Zanthia, additional, Williams, Natasha J., additional, Wisnivesky, Juan P., additional, Wood, John C., additional, Yee, Lynn M., additional, Young, Natalie M., additional, Zisis, Sokratis N., additional, and Foulkes, Andrea S., additional

Published
2023
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47. The Temporal Relationship Between the Coronavirus Disease 2019 (COVID-19) Pandemic and Preterm Birth

Author

Grobman, William A., primary, Sandoval, Grecio J., additional, Metz, Torri D., additional, Manuck, Tracy A., additional, Clifton, Rebecca G., additional, Hughes, Brenna L., additional, Saade, George R., additional, Longo, Monica, additional, Sowles, Amber, additional, Clark, Kelly, additional, Simhan, Hyagriv N., additional, Rouse, Dwight J., additional, Mendez-Figueroa, Hector, additional, Gyamfi-Bannerman, Cynthia, additional, Bailit, Jennifer L., additional, Costantine, Maged M., additional, Sehdev, Harish M., additional, Tita, Alan T. N., additional, and Macones, George A., additional

Published
2023
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48. Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design

Author

Metz, Torri D., primary, Clifton, Rebecca G., additional, Gallagher, Richard, additional, Gross, Rachel S., additional, Horwitz, Leora I., additional, Jacoby, Vanessa L., additional, Martin-Herz, Susanne P., additional, Peralta-Carcelen, Myriam, additional, Reeder, Harrison T., additional, Beamon, Carmen J., additional, Bind, Marie-Abele, additional, Chan, James, additional, Chang, A. Ann, additional, Chibnik, Lori B., additional, Costantine, Maged M., additional, Fitzgerald, Megan L., additional, Foulkes, Andrea S., additional, Gibson, Kelly S., additional, Güthe, Nick, additional, Habli, Mounira, additional, Hackney, David N., additional, Hoffman, Matthew K., additional, Hoffman, M. Camille, additional, Hughes, Brenna L., additional, Katz, Stuart D., additional, Laleau, Victoria, additional, Mallett, Gail, additional, Figueroa, Hector Mendez-, additional, Monzon, Vanessa, additional, Palatnik, Anna, additional, Palomares, Kristy T.S., additional, Parry, Samuel, additional, Pettker, Christian M., additional, Plunkett, Beth A., additional, Poppas, Athena, additional, Reddy, Uma M., additional, Rouse, Dwight J., additional, Saade, George R., additional, Sandoval, Grecio J., additional, Schlater, Shannon M., additional, Sciurba, Frank C., additional, Simhan, Hyagriv N., additional, Skupski, Daniel W., additional, Sowles, Amber, additional, Thaweethai, Tanayott, additional, Thomas, Gelise L., additional, Thorp, John M., additional, Tita, Alan T., additional, Weiner, Steven J., additional, Weigand, Samantha, additional, Yee, Lynn M., additional, and Flaherman, Valerie J., additional

Published
2023
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