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In large cohort studies it can be impractical to report individual data that only summary or aggregated data are available. Using aggregated data from Bernoulli trials is expected to result in overdispersion so that a quasi-binomial approach would seem feasible. We show that when applied to aggregated data arising from cohorts of individuals according to a chain binomial model, the quasi-binomial model results in biased estimates. We propose an alternate calibration estimator and demonstrate its improved performance by simulations. The calibration method is then applied to model the probability of leaving a personal emergency link service in Hong Kong. [ABSTRACT FROM AUTHOR]

The local polynomial methods and martingale estimating equations are used to develop closed form estimators of the intensity function and its derivatives for multiplicative counting process models. The consistency and asymptotic normality of the estimators are established. The estimator generalizes that proposed by Ramlau-Hansen (1983) with a smaller bias than the Ramlau-Hansen intensity estimator. The derivative estimators give smoother estimates than the Ramlau-Hansen derivative estimators. The proposed estimators are applied to analyze the infection rate and its derivatives of the 2003 Severe Acute Respiratory Syndrome (SARS) epidemic in Beijing, China. [ABSTRACT FROM AUTHOR]