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1. Design and Construction of the MicroBooNE Detector

Author: MicroBooNE Collaboration, Acciarri, R., Adams, C., An, R., Aparicio, A., Aponte, S., Asaadi, J., Auger, M., Ayoub, N., Bagby, L., Baller, B., Barger, R., Barr, G., Bass, M., Bay, F., Biery, K., Bishai, M., Blake, A., Bocean, V., Boehnlein, D., Bogert, V. D., Bolton, T., Bugel, L., Callahan, C., Camilleri, L., Caratelli, D., Carls, B., Fernandez, R. Castillo, Cavanna, F., Chappa, S., Chen, H., Chen, K., Chi, C. Y., Chiu, C. S., Church, E., Cianci, D., Collin, G. H., Conrad, J. M., Convery, M., Cornele, J., Cowan, P., Crespo-Anadon, J. I., Crutcher, G., Darve, C., Davis, R., Del Tutto, M., Devitt, D., Duffin, S., Dytman, S., Eberly, B., Ereditato, A., Erickson, D., Sanchez, L. Escudero, Esquivel, J., Farooq, S., Farrell, J., Featherston, D., Fleming, B. T., Foreman, W., Furmanski, A. P., Genty, V., Geynisman, M., Goeldi, D., Goff, B., Gollapinni, S., Graf, N., Gramellini, E., Green, J., Greene, A., Greenlee, H., Griffin, T., Grosso, R., Guenette, R., Hackenburg, A., Haenni, R., Hamilton, P., Healey, P., Hen, O., Henderson, E., Hewes, V, Hill, C., Hill, K., Himes, L., Ho, J., Horton-Smith, G., Huffman, D., Ignarra, C. M., James, C., James, E., de Vries, J. Jan, Jaskierny, W., Jen, C. M., Jiang, L., Johnson, B., Johnson, M., Johnson, R. A., Jones, B. J. P., Joshi, J., Jostlein, H., Kaleko, D., Kalousis, L. N., Karagiorgi, G., Katori, T., Kellogg, P., Ketchum, W., Kilmer, J., King, B., Kirby, B., Kirby, M., Klein, E., Kobilarcik, T., Kreslo, I., Krull, R., Kubinski, R., Lange, G., Lanni, F., Lathrop, A., Laube, A., Lee, W. M., Li, Y., Lissauer, D., Lister, A., Littlejohn, B. R., Lockwitz, S., Lorca, D., Louis, W. C., Lukhanin, G., Luethi, M., Lundberg, B., Luo, X., Mahler, G., Majoros, I., Makowiecki, D., Marchionni, A., Mariani, C., Markley, D., Marshall, J., Caicedo, D. A. Martinez, McDonald, K. T., McKee, D., McLean, A., Mead, J., Meddage, V., Miceli, T., Mills, G. B., Miner, W., Moon, J., Mooney, M., Moore, C. D., Moss, Z., Mousseau, J., Murrells, R., Naples, D., Nienaber, P., Norris, B., Norton, N., Nowak, J., OBoyle, M., Olszanowski, T., Palamara, O., Paolone, V., Papavassiliou, V., Pate, S. F., Pavlovic, Z., Pelkey, R., Phipps, M., Pordes, S., Porzio, D., Pulliam, G., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Rameika, R. A, Rebel, B., Rechenmacher, R., Rescia, S., Rochester, L., von Rohr, C. Rudolf, Ruga, A., Russell, B., Sanders, R., Sands III, W. R., Sarychev, M., Schmitz, D. W., Schukraft, A., Scott, R., Seligman, W., Shaevitz, M. H., Shoun, M., Sinclair, J., Sippach, W., Smidt, T., Smith, A., Snider, E. L., Soderberg, M., Solano-Gonzalez, M., Soldner-Rembold, S., Soleti, S. R., Sondericker, J., Spentzouris, P., Spitz, J., John, J. St., Strauss, T., Sutton, K., Szelc, A. M., Taheri, K., Tagg, N., Tatum, K., Teng, J., Terao, K., Thomson, M., Thorn, C., Tillman, J., Toups, M., Tsai, Y. T., Tufanli, S., Usher, T., Utes, M., Van de Water, R. G., Vendetta, C., Vergani, S., Voirin, E., Voirin, J., Viren, B., Watkins, P., Weber, M., Wester, T., Weston, J., Wickremasinghe, D. A., Wolbers, S., Wongjirad, T., Woodruff, K., Wu, K. C., Yang, T., Yu, B., Zeller, G. P., Zennamo, J., Zhang, C., and Zuckerbrot, M.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: This paper describes the design and construction of the MicroBooNE liquid argon time projection chamber and associated systems. MicroBooNE is the first phase of the Short Baseline Neutrino program, located at Fermilab, and will utilize the capabilities of liquid argon detectors to examine a rich assortment of physics topics. In this document details of design specifications, assembly procedures, and acceptance tests are reported.
Published: 2016
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2. Design and construction of the MicroBooNE detector

Author: Acciarri, R, Adams, C, An, R, Aparicio, A, Aponte, S, Asaadi, J, Auger, M, Ayoub, N, Bagby, L, Baller, B, Barger, R, Barr, G, Bass, M, Bay, F, Biery, K, Bishai, M, Blake, A, Bocean, V, Boehnlein, D, Bogert, VD, Bolton, T, Bugel, L, Callahan, C, Camilleri, L, Caratelli, D, Carls, B, Castillo Fernandez, R, Cavanna, F, Chappa, S, Chen, H, Chen, K, Chi, CY, Chiu, CS, Church, E, Cianci, D, Collin, GH, Conrad, JM, Convery, M, Cornele, J, Cowan, P, Crespo-Anadon, JI, Crutcher, G, Darve, C, Davis, R, Del Tutto, M, Devitt, D, Duffin, S, Dytman, S, Eberly, B, Ereditato, A, Erickson, D, Escudero Sanchez, L, Esquivel, J, Farooq, S, Farrell, J, Featherston, D, Fleming, BT, Foreman, W, Furmanski, AP, Genty, V, Geynisman, M, Goeldi, D, Goff, B, Gollapinni, S, Graf, N, Gramellini, E, Green, J, Greene, A, Greenlee, H, Griffin, T, Grosso, R, Guenette, R, Hackenburg, A, Haenni, R, Hamilton, P, Healey, P, Hen, O, Henderson, E, Hewes, J, Hill, C, Hill, K, Himes, L, Ho, J, Horton-Smith, G, Huffman, D, Ignarra, CM, James, C, James, E, Jan De Vries, J, Jaskierny, W, Jen, CM, Jiang, L, Johnson, B, Johnson, M, Johnson, RA, Jones, BJP, Joshi, J, Jostlein, H, Kaleko, D, and Kalousis, LN
Subjects: Neutrino detectors, Noble liquid detectors, Time projection chambers, physics.ins-det, hep-ex, Nuclear & Particles Physics, Other Physical Sciences, Physical Sciences, Engineering
Abstract: This paper describes the design and construction of the MicroBooNE liquid argon time projection chamber and associated systems. MicroBooNE is the first phase of the Short Baseline Neutrino program, located at Fermilab, and will utilize the capabilities of liquid argon detectors to examine a rich assortment of physics topics. In this document details of design specifications, assembly procedures, and acceptance tests are reported.
Published: 2017

3. The Dark Energy Camera

Author: Flaugher, B., Diehl, H. T., Honscheid, K., Abbott, T. M. C., Alvarez, O., Angstadt, R., Annis, J. T., Antonik, M., Ballester, O., Beaufore, L., Bernstein, G. M., Bernstein, R. A., Bigelow, B., Bonati, M., Boprie, D., Brooks, D., Buckley-Geer, E. J., Campa, J., Cardiel-Sas, L., Castander, F. J., Castilla, J., Cease, H., Cela-Ruiz, J. M., Chappa, S., Chi, E., Cooper, C., da Costa, L. N., Dede, E., Derylo, G., DePoy, D. L., de Vicente, J., Doel, P., Drlica-Wagner, A., Eiting, J., Elliott, A. E., Emes, J., Estrada, J., Neto, A. Fausti, Finley, D. A., Flores, R., Frieman, J., Gerdes, D., Gladders, M. D., Gregory, B., Gutierrez, G. R., Hao, J., Holland, S. E., Holm, S., Huffman, D., Jackson, C., James, D. J., Jonas, M., Karcher, A., Karliner, I., Kent, S., Kessler, R., Kozlovsky, M., Kron, R. G., Kubik, D., Kuehn, K., Kuhlmann, S., Kuk, K., Lahav, O., Lathrop, A., Lee, J., Levi, M. E., Lewis, P., Li, T. S., Mandrichenko, I., Marshall, J. L., Martinez, G., Merritt, K. W., Miquel, R., Munoz, F., Neilsen, E. H., Nichol, R. C., Nord, B., Ogando, R., Olsen, J., Palio, N., Patton, K., Peoples, J., Plazas, A. A., Rauch, J., Reil, K., Rheault, J. -P., Roe, N. A., Rogers, H., Roodman, A., Sanchez, E., Scarpine, V., Schindler, R. H., Schmidt, R., Schmitt, R., Schubnell, M., Schultz, K., Schurter, P., Scott, L., Serrano, S., Shaw, T. M., Smith, R. C., Soares-Santos, M., Stefanik, A., Stuermer, W., Suchyta, E., Sypniewski, A., Tarle, G., Thaler, J., Tighe, R., Tran, C., Tucker, D., Walker, A. R., Wang, G., Watson, M., Weaverdyck, C., Wester, W., Woods, R., and Yanny, B.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Dark Energy Camera is a new imager with a 2.2-degree diameter field of view mounted at the prime focus of the Victor M. Blanco 4-meter telescope on Cerro Tololo near La Serena, Chile. The camera was designed and constructed by the Dark Energy Survey Collaboration, and meets or exceeds the stringent requirements designed for the wide-field and supernova surveys for which the collaboration uses it. The camera consists of a five element optical corrector, seven filters, a shutter with a 60 cm aperture, and a CCD focal plane of 250 micron thick fully-depleted CCDs cooled inside a vacuum Dewar. The 570 Mpixel focal plane comprises 62 2kx4k CCDs for imaging and 12 2kx2k CCDs for guiding and focus. The CCDs have 15 microns x15 microns pixels with a plate scale of 0.263 arc sec per pixel. A hexapod system provides state-of-the-art focus and alignment capability. The camera is read out in 20 seconds with 6-9 electrons readout noise. This paper provides a technical description of the camera's engineering, construction, installation, and current status., Comment: submitted to AJ Corresponding Authors H. T. Diehl (diehl@fnal.gov)
Published: 2015
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4. Mu2e Technical Design Report

Author: Bartoszek, L., Barnes, E., Miller, J. P., Mott, J., Palladino, A., Quirk, J., Roberts, B. L., Crnkovic, J., Polychronakos, V., Tishchenko, V., Yamin, P., Cheng, C. -h., Echenard, B., Flood, K., Hitlin, D. G., Kim, J. H., Miyashita, T. S., Porter, F. C., Röhrken, M., Trevor, J., Zhu, R. -Y., Heckmaier, E., Kang, T. I., Lim, G., Molzon, W., You, Z., Artikov, A. M., Budagov, J. A., Davydov, Yu. I., Glagolev, V. V., Simonenko, A. V., Usubov, Z. U., Oh, S. H., Wang, C., Ambrosio, G., Andreev, N., Arnold, D., Ball, M., Bernstein, R. H., Bianchi, A., Biery, K., Bossert, R., Bowden, M., Brandt, J., Brown, G., Brown, H., Buehler, M., Campbell, M., Cheban, S., Chen, M., Coghill, J., Coleman, R., Crowley, C., Deshpande, A., Deuerling, G., Dey, J., Dhanaraj, N., Dinnon, M., Dixon, S., Drendel, B., Eddy, N., Evans, R., Evbota, D., Fagan, J., Feher, S., Fellenz, B., Friedsam, H., Gallo, G., Gaponenko, A., Gardner, M., Gaugel, S., Genser, K., Ginther, G., Glass, H., Glenzinski, D., Hahn, D., Hansen, S., Hartsell, B., Hays, S., Hocker, J. A., Huedem, E., Huffman, D., Ibrahim, A., Johnstone, C., Kashikhin, V., Kashikhin, V. V., Kasper, P., Kiper, T., Knapp, D., Knoepfel, K., Kokoska, L., Kozlovsky, M., Krafczyk, G., Kramp, M., Krave, S., Krempetz, K., Kutschke, R. K., Kwarciany, R., Lackowski, T., Lamm, M. J., Larwill, M., Leavell, F., Leeb, D., Leveling, A., Lincoln, D., Logashenko, V., Lombardo, V., Lopes, M. L., Makulski, A., Martinez, A., McArthur, D., McConologue, F., Michelotti, L., Mokhov, N., Morgan, J., Mukherjee, A., Murat, P., Nagaslaev, V., Neuffer, D. V., Nicol, T., Niehoff, J., Nogiec, J., Olson, M., Orris, D., Ostojic, R., Page, T., Park, C., Peterson, T., Pilipenko, R., Pla-Dalmau, A., Poloubotko, V., Popovic, M., Prebys, E., Prieto, P., Pronskikh, V., Pushka, D., Rabehl, R., Ray, R. E., Rechenmacher, R., Rivera, R., Robotham, W., Rubinov, P., Rusu, V. L., Scarpine, V., Schappert, W., Schoo, D., Stefanik, A., Still, D., Tang, Z., Tanovic, N., Tartaglia, M., Tassotto, G., Tinsley, D., Tschirhart, R. S., Vogel, G., Wagner, R., Wands, R., Wang, M., Werkema, S., White Jr., H. B., Whitmore, J., Wielgos, R., Woods, R., Worel, C., Zifko, R., Ciambrone, P., Colao, F., Cordelli, M., Corradi, G., Dane, E., Giovannella, S., Happacher, F., Luca, A., Miscetti, S., Ponzio, B., Pileggi, G., Saputi, A., Sarra, I., Soleti, R. S., Stomaci, V., Martini, M., Fabbricatore, P., Farinon, S., Musenich, R., Alexander, D., Daniel, A., Empl, A., Hungerford, E. V., Lau, K., Gollin, G. D., Huang, C., Roderick, D., Trundy, B., Brown, D. Na., Ding, D., Kolomensky, Yu. G., Lee, M. J., Cascella, M., Grancagnolo, F., Ignatov, F., Innocente, A., L'Erario, A., Miccoli, A., Maffezzoli, A., Mazzotta, P., Onorato, G., Piacentino, G. M., Rella, S., Rossetti, F., Spedicato, M., Tassielli, G., Taurino, A., Zavarise, G., Hooper, R., Brown, D. No., Djilkibaev, R., Matushko, V., Ankenbrandt, C., Boi, S., Dychkant, A., Hedin, D., Hodge, Z., Khalatian, V., Majewski, R., Martin, L., Okafor, U., Pohlman, N., Riddel, R. S., Shellito, A., de Gouvea, A. L., Cervelli, F., Carosi, R., Di Falco, S., Donati, S., Lomtadze, T., Pezzullo, G., Ristori, L., Spinella, F., Jones, M., Corcoran, M. D., Orduna, J., Rivera, D., Bennett, R., Caretta, O., Davenne, T., Densham, C., Loveridge, P., Odell, J., Bomgardner, R., Dukes, E. C., Ehrlich, R., Frank, M., Goadhouse, S., Group, R., Ho, E., Ma, H., Oksuzian, Y., Purvis, J., Wu, Y., Hertzog, D. W., Kammel, P., Lynch, K. R., and Popp, J. L.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The Mu2e experiment at Fermilab will search for charged lepton flavor violation via the coherent conversion process mu- N --> e- N with a sensitivity approximately four orders of magnitude better than the current world's best limits for this process. The experiment's sensitivity offers discovery potential over a wide array of new physics models and probes mass scales well beyond the reach of the LHC. We describe herein the preliminary design of the proposed Mu2e experiment. This document was created in partial fulfillment of the requirements necessary to obtain DOE CD-2 approval., Comment: compressed file, 888 pages, 621 figures, 126 tables; full resolution available at http://mu2e.fnal.gov; corrected typo in background summary, Table 3.4
Published: 2015

5. Incentive complexity, bounded rationality and effort provision

Author: Abeler, J, Huffman, D, and Raymond, C
Subjects: ratchet effect, shrouded attributes, bounded rationality, complexity, field experiments
Abstract: This paper shows that dynamic incentives embedded in an organization��s workplace incentive scheme can be a shrouded attribute, due to contract complexity and worker bounded rationality. This is true in field experiments within the firm, and in complementary online experiments with real effort tasks. Structural estimates indicate that rational agents who fully understand the incentive scheme would behave sigificantly different from what we observe. A response to dynamic incentives does emerge when we reduce complexity or look at workers with higher cognitive ability. The results illustrate the potential value of complexity to organizations, they demonstrate that complex incentive contracts may allow firms to be achieve better than second-best, they identify specific features of contracts that can influence the effectiveness of incentives through the channel of complexity, and they imply heterogeneous effects of incentives depending on worker cognitive ability.
Published: 2023

6. Experimental Exposure of Adult San Marcos Salamanders and Larval Leopard Frogs to the Cercariae of Centrocestus formosanus

Author: Huston, D. C., Cantu, V., and Huffman, D. G.
Published: 2014

7. Production of low fat and reduced fat ground beef

Author: Huffman, D. L., Huffman, R. D., Pearson, A. M., editor, and Dutson, T. R., editor
Published: 1997
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8. RTP™ Biocrude: A Combustion / Emissions Review

Author: Huffman, D. R., Freel, B. A., Bridgwater, A. V., editor, and Boocock, D. G. B., editor
Published: 1997
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9. Proposed Specifications for Various Grades of Pyrolysis Oils

Author: Diebold, J. P., Milne, T. A., Czernik, S., Oasmaa, A., Bridgwater, A. V., Cuevas, A., Gust, S., Huffman, D., Piskorz, J., Bridgwater, A. V., editor, and Boocock, D. G. B., editor
Published: 1997
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10. The Characterization of Fast Pyrolysis Bio-Oils

Author: Huffman, D. R., Vogiatzis, A. J., Bridgwater, A. V., and Bridgwater, A. V., editor
Published: 1993
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11. Applications of Rapid Thermal Processing of Biomass

Author: Graham, Robert G., Freel, Barry A., Huffman, D. R., Bergougnou, Maurice A., and Bridgwater, A. V., editor
Published: 1993
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12. Search for the UV and IR Spectra of C6 0 in Laboratory-Produced Carbon Dust

Author: Krätschmer, W., Fostiropoulos, K., Huffman, D. R., Bussoletti, E., editor, and Vittone, A. A., editor
Published: 1990
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13. Advances In Coding Theory And Cryptography

Author: Tanush Shaska, W C Huffman, D Joyner
Published: 2007

14. Application of Polarization Effects in Light Scattering: A New Biophysical Tool

Author: Bickel, W. S., Davidson, J. F., Huffman, D. R., and Kilkson, R.
Published: 1976

15. A Significant Morphogenetic Variant of Dictyostelium mucoroides

Author: Huffman, D. M. and Olive, L. S.
Published: 1963
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16. Anastomosis and Cell Fusions in Dictyostelium

Author: Huffman, D. M., Kahn, A. J., and Olive, L. S.
Published: 1962

17. Engulfment and Anastomosis in the Cellular Slime Molds (Acrasiales)

Author: Huffman, D. M. and Olive, L. S.
Published: 1964

18. The upgraded DØ detector

Author: Abazov, V.M., Abbott, B., Abolins, M., Acharya, B.S., Adams, D.L., Adams, M., Adams, T., Agelou, M., Agram, J.-L., Ahmed, S.N., Ahn, S.H., Ahsan, M., Alexeev, G.D., Alkhazov, G., Alton, A., Alverson, G., Alves, G.A., Anastasoaie, M., Andeen, T., Anderson, J.T., Anderson, S., Andrieu, B., Angstadt, R., Anosov, V., Arnoud, Y., Arov, M., Askew, A., Åsman, B., Assis Jesus, A.C.S., Atramentov, O., Autermann, C., Avila, C., Babukhadia, L., Bacon, T.C., Badaud, F., Baden, A., Baffioni, S., Bagby, L., Baldin, B., Balm, P.W., Banerjee, P., Banerjee, S., Barberis, E., Bardon, O., Barg, W., Bargassa, P., Baringer, P., Barnes, C., Barreto, J., Bartlett, J.F., Bassler, U., Bhattacharjee, M., Baturitsky, M.A., Bauer, D., Bean, A., Baumbaugh, B., Beauceron, S., Begalli, M., Beaudette, F., Begel, M., Bellavance, A., Beri, S.B., Bernardi, G., Bernhard, R., Bertram, I., Besançon, M., Besson, A., Beuselinck, R., Beutel, D., Bezzubov, V.A., Bhat, P.C., Bhatnagar, V., Binder, M., Biscarat, C., Bishoff, A., Black, K.M., Blackler, I., Blazey, G., Blekman, F., Blessing, S., Bloch, D., Blumenschein, U., Bockenthien, E., Bodyagin, V., Boehnlein, A., Boeriu, O., Bolton, T.A., Bonamy, P., Bonifas, D., Borcherding, F., Borissov, G., Bos, K., Bose, T., Boswell, C., Bowden, M., Brandt, A., Briskin, G., Brock, R., Brooijmans, G., Bross, A., Buchanan, N.J., Buchholz, D., Buehler, M., Buescher, V., Burdin, S., Burke, S., Burnett, T.H., Busato, E., Buszello, C.P., Butler, D., Butler, J.M., Cammin, J., Caron, S., Bystricky, J., Canal, L., Canelli, F., Carvalho, W., Casey, B.C.K., Casey, D., Cason, N.M., Castilla-Valdez, H., Chakrabarti, S., Chakraborty, D., Chan, K.M., Chandra, A., Chapin, D., Charles, F., Cheu, E., Chevalier, L., Chi, E., Chiche, R., Cho, D.K., Choate, R., Choi, S., Choudhary, B., Chopra, S., Christenson, J.H., Christiansen, T., Christofek, L., Churin, I., Cisko, G., Claes, D., Clark, A.R., Clément, B., Clément, C., Coadou, Y., Colling, D.J., Coney, L., Connolly, B., Cooke, M., Cooper, W.E., Coppage, D., Corcoran, M., Coss, J., Cothenet, A., Cousinou, M.-C., Cox, B., Crépé-Renaudin, S., Cristetiu, M., Cummings, M.A.C., Cutts, D., da Motta, H., Das, M., Davies, B., Davies, G., Davis, G.A., Davis, W., De, K., de Jong, P., de Jong, S.J., De La Cruz-Burelo, E., De La Taille, C., De Oliveira Martins, C., Dean, S., Degenhardt, J.D., Déliot, F., Delsart, P.A., Del Signore, K., DeMaat, R., Demarteau, M., Demina, R., Demine, P., Denisov, D., Denisov, S.P., Desai, S., Diehl, H.T., Diesburg, M., Doets, M., Doidge, M., Dong, H., Doulas, S., Dudko, L.V., Duflot, L., Dugad, S.R., Duperrin, A., Dvornikov, O., Dyer, J., Dyshkant, A., Eads, M., Edmunds, D., Edwards, T., Ellison, J., Elmsheuser, J., Eltzroth, J.T., Elvira, V.D., Eno, S., Ermolov, P., Eroshin, O.V., Estrada, J., Evans, D., Evans, H., Evdokimov, A., Evdokimov, V.N., Fagan, J., Fast, J., Fatakia, S.N., Fein, D., Feligioni, L., Ferapontov, A.V., Ferbel, T., Ferreira, M.J., Fiedler, F., Filthaut, F., Fisher, W., Fisk, H.E., Fleck, I., Fitzpatrick, T., Flattum, E., Fleuret, F., Flores, R., Foglesong, J., Fortner, M., Fox, H., Franklin, C., Freeman, W., Fu, S., Fuess, S., Gadfort, T., Galea, C.F., Gallas, E., Galyaev, E., Gao, M., Garcia, C., Garcia-Bellido, A., Gardner, J., Gavrilov, V., Gay, A., Gay, P., Gelé, D., Gelhaus, R., Genser, K., Gerber, C.E., Gershtein, Y., Gillberg, D., Geurkov, G., Ginther, G., Gobbi, B., Goldmann, K., Golling, T., Gollub, N., Golovtsov, V., Gómez, B., Gomez, G., Gomez, R., Goodwin, R., Gornushkin, Y., Gounder, K., Goussiou, A., Graham, D., Graham, G., Grannis, P.D., Gray, K., Greder, S., Green, D.R., Green, J., Green, J.A., Greenlee, H., Greenwood, Z.D., Gregores, E.M., Grinstein, S., Gris, Ph., Grivaz, J.-F., Groer, L., Grünendahl, S., Grünewald, M.W., Gu, W., Guglielmo, J., Gupta, A., Gurzhiev, S.N., Gutierrez, G., Gutierrez, P., Haas, A., Hadley, N.J., Haggard, E., Haggerty, H., Hagopian, S., Hall, I., Hall, R.E., Han, C., Han, L., Hance, R., Hanagaki, K., Hanlet, P., Hansen, S., Harder, K., Harel, A., Harrington, R., Hauptman, J.M., Hauser, R., Hays, C., Hays, J., Hazen, E., Hebbeker, T., Hebert, C., Hedin, D., Heinmiller, J.M., Heinson, A.P., Heintz, U., Hensel, C., Hesketh, G., Hildreth, M.D., Hirosky, R., Hobbs, J.D., Hoeneisen, B., Hohlfeld, M., Hong, S.J., Hooper, R., Hou, S., Houben, P., Hu, Y., Huang, J., Huang, Y., Hynek, V., Huffman, D., Iashvili, I., Illingworth, R., Ito, A.S., Jabeen, S., Jacquier, Y., Jaffré, M., Jain, S., Jain, V., Jakobs, K., Jayanti, R., Jenkins, A., Jesik, R., Jiang, Y., Johns, K., Johnson, M., Johnson, P., Jonckheere, A., Jonsson, P., Jöstlein, H., Jouravlev, N., Juarez, M., Juste, A., Kaan, A.P., Kado, M.M., Käfer, D., Kahl, W., Kahn, S., Kajfasz, E., Kalinin, A.M., Kalk, J., Kalmani, S.D., Karmanov, D., Kasper, J., Katsanos, I., Kau, D., Kaur, R., Ke, Z., Kehoe, R., Kermiche, S., Kesisoglou, S., Khanov, A., Kharchilava, A., Kharzheev, Y.M., Kim, H., Kim, K.H., Kim, T.J., Kirsch, N., Klima, B., Klute, M., Kohli, J.M., Konrath, J.-P., Komissarov, E.V., Kopal, M., Korablev, V.M., Kostritski, A., Kotcher, J., Kothari, B., Kotwal, A.V., Koubarovsky, A., Kozelov, A.V., Kozminski, J., Kryemadhi, A., Kouznetsov, O., Krane, J., Kravchuk, N., Krempetz, K., Krider, J., Krishnaswamy, M.R., Krzywdzinski, S., Kubantsev, M., Kubinski, R., Kuchinsky, N., Kuleshov, S., Kulik, Y., Kumar, A., Kunori, S., Kupco, A., Kurča, T., Kvita, J., Kuznetsov, V.E., Kwarciany, R., Lager, S., Lahrichi, N., Landsberg, G., Larwill, M., Laurens, P., Lavigne, B., Lazoflores, J., Le Bihan, A.-C., Le Meur, G., Lebrun, P., Lee, S.W., Lee, W.M., Leflat, A., Leggett, C., Lehner, F., Leitner, R., Leonidopoulos, C., Leveque, J., Lewis, P., Li, J., Li, Q.Z., Li, X., Lima, J.G.R., Lincoln, D., Lindenmeyer, C., Linn, S.L., Linnemann, J., Lipaev, V.V., Lipton, R., Litmaath, M., Lizarazo, J., Lobo, L., Lobodenko, A., Lokajicek, M., Lounis, A., Love, P., Lu, J., Lubatti, H.J., Lucotte, A., Lueking, L., Luo, C., Lynker, M., Lyon, A.L., Machado, E., Maciel, A.K.A., Madaras, R.J., Mättig, P., Magass, C., Magerkurth, A., Magnan, A.-M., Maity, M., Makovec, N., Mal, P.K., Malbouisson, H.B., Malik, S., Malyshev, V.L., Manakov, V., Mao, H.S., Maravin, Y., Markley, D., Markus, M., Marshall, T., Martens, M., Martin, M., Martin-Chassard, G., Mattingly, S.E.K., Matulik, M., Mayorov, A.A., McCarthy, R., McCroskey, R., McKenna, M., McMahon, T., Meder, D., Melanson, H.L., Melnitchouk, A., Mendes, A., Mendoza, D., Mendoza, L., Meng, X., Merekov, Y.P., Merkin, M., Merritt, K.W., Meyer, A., Meyer, J., Michaut, M., Miao, C., Miettinen, H., Mihalcea, D., Mikhailov, V., Miller, D., Mitrevski, J., Mokhov, N., Molina, J., Mondal, N.K., Montgomery, H.E., Moore, R.W., Moulik, T., Muanza, G.S., Mostafa, M., Moua, S., Mulders, M., Mundim, L., Mutaf, Y.D., Nagaraj, P., Nagy, E., Naimuddin, M., Nang, F., Narain, M., Narasimhan, V.S., Narayanan, A., Naumann, N.A., Neal, H.A., Negret, J.P., Nelson, S., Neuenschwander, R.T., Neustroev, P., Noeding, C., Nomerotski, A., Novaes, S.F., Nozdrin, A., Nunnemann, T., Nurczyk, A., Nurse, E., O’Dell, V., O’Neil, D.C., Oguri, V., Olis, D., Oliveira, N., Olivier, B., Olsen, J., Oshima, N., Oshinowo, B.O., Otero y Garzón, G.J., Padley, P., Papageorgiou, K., Parashar, N., Park, J., Park, S.K., Parsons, J., Partridge, R., Parua, N., Patwa, A., Pawloski, G., Perea, P.M., Perez, E., Peters, O., Pétroff, P., Petteni, M., Phaf, L., Piegaia, R., Pleier, M.-A., Podesta-Lerma, P.L.M., Podstavkov, V.M., Pogorelov, Y., Pol, M.-E., Pompoš, A., Polosov, P., Pope, B.G., Popkov, E., Porokhovoy, S., Prado da Silva, W.L., Pritchard, W., Prokhorov, I., Prosper, H.B., Protopopescu, S., Przybycien, M.B., Qian, J., Quadt, A., Quinn, B., Ramberg, E., Ramirez-Gomez, R., Rani, K.J., Ranjan, K., Rao, M.V.S., Rapidis, P.A., Rapisarda, S., Raskowski, J., Ratoff, P.N., Ray, R.E., Reay, N.W., Rechenmacher, R., Reddy, L.V., Regan, T., Renardy, J.-F., Reucroft, S., Rha, J., Ridel, M., Rijssenbeek, M., Ripp-Baudot, I., Rizatdinova, F., Robinson, S., Rodrigues, R.F., Roco, M., Rotolo, C., Royon, C., Rubinov, P., Ruchti, R., Rucinski, R., Rud, V.I., Russakovich, N., Russo, P., Sabirov, B., Sajot, G., Sánchez-Hernández, A., Sanders, M.P., Santoro, A., Satyanarayana, B., Savage, G., Sawyer, L., Scanlon, T., Schaile, D., Schamberger, R.D., Scheglov, Y., Schellman, H., Schieferdecker, P., Schmitt, C., Schwanenberger, C., Schukin, A.A., Schwartzman, A., Schwienhorst, R., Sengupta, S., Severini, H., Shabalina, E., Shamim, M., Shankar, H.C., Shary, V., Shchukin, A.A., Sheahan, P., Shephard, W.D., Shivpuri, R.K., Shishkin, A.A., Shpakov, D., Shupe, M., Sidwell, R.A., Simak, V., Sirotenko, V., Skow, D., Skubic, P., Slattery, P., Smith, D.E., Smith, R.P., Smolek, K., Snow, G.R., Snow, J., Snyder, S., Söldner-Rembold, S., Song, X., Song, Y., Sonnenschein, L., Sopczak, A., Sorín, V., Sosebee, M., Soustruznik, K., Souza, M., Spartana, N., Spurlock, B., Stanton, N.R., Stark, J., Steele, J., Stefanik, A., Steinberg, J., Steinbrück, G., Stevenson, K., Stolin, V., Stone, A., Stoyanova, D.A., Strandberg, J., Strang, M.A., Strauss, M., Ströhmer, R., Strom, D., Strovink, M., Stutte, L., Sumowidagdo, S., Sznajder, A., Talby, M., Tentindo-Repond, S., Tamburello, P., Taylor, W., Telford, P., Temple, J., Terentyev, N., Teterin, V., Thomas, E., Thompson, J., Thooris, B., Titov, M., Toback, D., Tokmenin, V.V., Tolian, C., Tomoto, M., Tompkins, D., Toole, T., Torborg, J., Touze, F., Towers, S., Trefzger, T., Trincaz-Duvoid, S., Trippe, T.G., Tsybychev, D., Tuchming, B., Tully, C., Turcot, A.S., Tuts, P.M., Utes, M., Uvarov, L., Uvarov, S., Uzunyan, S., Vachon, B., van den Berg, P.J., van Gemmeren, P., Van Kooten, R., van Leeuwen, W.M., Varelas, N., Varnes, E.W., Vartapetian, A., Vasilyev, I.A., Vaupel, M., Vaz, M., Verdier, P., Vertogradov, L.S., Verzocchi, M., Vigneault, M., Villeneuve-Seguier, F., Vishwanath, P.R., Vlimant, J.-R., Von Toerne, E., Vorobyov, A., Vreeswijk, M., Vu Anh, T., Vysotsky, V., Wahl, H.D., Walker, R., Wallace, N., Wang, L., Wang, Z.-M., Warchol, J., Warsinsky, M., Watts, G., Wayne, M., Weber, M., Weerts, H., Wegner, M., Wermes, N., Wetstein, M., White, A., White, V., Whiteson, D., Wicke, D., Wijnen, T., Wijngaarden, D.A., Wilcer, N., Willutzki, H., Wilson, G.W., Wimpenny, S.J., Wittlin, J., Wlodek, T., Wobisch, M., Womersley, J., Wood, D.R., Wyatt, T.R., Wu, Z., Xie, Y., Xu, Q., Xuan, N., Yacoob, S., Yamada, R., Yan, M., Yarema, R., Yasuda, T., Yatsunenko, Y.A., Yen, Y., Yip, K., Yoo, H.D., Yoffe, F., Youn, S.W., Yu, J., Yurkewicz, A., Zabi, A., Zanabria, M., Zatserklyaniy, A., Zdrazil, M., Zeitnitz, C., Zhang, B., Zhang, D., Zhang, X., Zhao, T., Zhao, Z., Zheng, H., Zhou, B., Zhu, J., Zielinski, M., Zieminska, D., Zieminski, A., Zitoun, R., Zmuda, T., Zutshi, V., Zviagintsev, S., Zverev, E.G., and Zylberstejn, A.
Published: 2006
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19. How professional nurses working in hospital environments experience moral distress: a updated systematic review

Author: Rittenmeyer, L M and Huffman, D
Published: 2012

20. The city of Milwaukee crytosporidium outbreak: What really happened and how vulnerable are we?

Author: Huffman, D. E., primary
Published: 2007
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21. How families and healthcare practitioners experience family presence during resuscitation and invasive procedures: a systematic review

Author: Huffman, D and Rittenmeyer, L
Published: 2010
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22. How professional nurses working in hospital environments experience moral distress: a systematic review

Author: Rittenmeyer, L and Huffman, D
Published: 2009

23. A nucleic acid sequence-based amplification assay for real-time detection of norovirus genogroup II

Author: Patterson, S. S., Smith, M. W., Casper, E. T., Huffman, D., Stark, L., Fries, D., and Paul, J. H.
Published: 2006

24. EFFECT OF N-3 FATTY ACID SUPPLEMENTATION ON FREE TRYPTOPHAN AND FATIGUE DURING EXERCISE

Author: Huffman, D M., Thomas, T R., Altena, T S., and Mawhinney, T P.
Published: 2003

25. Cloud condensation nuclei (CCN) measurements at a remote continental station in central europe (mt. sonnblick observatory; Austria)

Author: Hitzenberger, R, primary, Geebl, H., additional, Berner, A., additional, Puxbaum, H., additional, Kasper, A., additional, and Huffman, D., additional
Published: 1996
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26. High resolution LCOS microdisplay for single-, double- or triple-panel projection systems

Author: Jepsen, M.L., Ammer, M.J., Bolotski, M., Drolet, J.J., Gupta, A., Lai, Y., Huffman, D., Shi, H., and Vieri, C.
Published: 2002
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27. Density, ages, and growth rates in old-growth and young-growth forests in coastal Oregon

Author: Tappeiner, J C, Huffman, D W, Marshall, D, Spies, T A, and Bailey, J D
Published: 1997

28. Search for the UV and IR Spectra of C6 0 in Laboratory-Produced Carbon Dust

Author: Krätschmer, W., primary, Fostiropoulos, K., additional, and Huffman, D. R., additional
Published: 1990
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29. Telomeres and Longevity: A Cause or an Effect?

Author: Adwan Shekhidem, H, Sharvit, L, Leman, E, Manov, I, Roichman, A, Holtze, S, M Huffman, D, Y Cohen, H, Bernd Hildebrandt, T, Shams, I, Atzmon, G, Adwan Shekhidem, H, Sharvit, L, Leman, E, Manov, I, Roichman, A, Holtze, S, M Huffman, D, Y Cohen, H, Bernd Hildebrandt, T, Shams, I, and Atzmon, G
Abstract: Telomere dynamics have been found to be better predictors of survival and mortality than chronological age. Telomeres, the caps that protect the end of linear chromosomes, are known to shorten with age, inducing cell senescence and aging. Furthermore, differences in age-related telomere attrition were established between short-lived and long-lived organisms. However, whether telomere length is a "biological thermometer" that reflects the biological state at a certain point in life or a biomarker that can influence biological conditions, delay senescence and promote longevity is still an ongoing debate. We cross-sectionally tested telomere length in different tissues of two long-lived (naked mole-rat and Spalax) and two short-lived (rat and mice) species to tease out this enigma. While blood telomere length of the naked mole-rat (NMR) did not shorten with age but rather showed a mild elongation, telomere length in three tissues tested in the Spalax declined with age, just like in short-lived rodents. These findings in the NMR, suggest an age buffering mechanism, while in Spalax tissues the shortening of the telomeres are in spite of its extreme longevity traits. Therefore, using long-lived species as models for understanding the role of telomeres in longevity is of great importance since they may encompass mechanisms that postpone aging.
Published: 2019

30. Empagliflozin and Kidney Function Decline in Patients with Type 2 Diabetes: A Slope Analysis from the EMPA-REG OUTCOME Trial

Author: Wanner, Christoph, Heerspink, Hiddo J. 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T., Moodley, R., Lombaard, J., Govind, U., Naidoo, V., Mookadam, M., Engelbrecht, J., Omar, M., Jurgens, J., Podgorski, G., Vawda, H., Naidoo, D., Emanuel, S., Roodt, A., Amod, A., Van Zyl, L., Segura, J., Brito, M., Fernandez-Cruz, A., Artola, S., Iglesias, R., Toural, E., Garcia-Ortiz, L., Saban, J., Mesa, J., Vidal, J., Linares, J., del Canizo, F., Rigla, M., Suarez, C., Llorente, I., Moreno, B., Antoli, A., Gomez Peralta, F., Iglesias, M., Pereg, V., de Teresa, L., Camafort, M., Trescoli, C., Satarasinghe, R., Somasundaram, N., Siyambalapitiya, S., Antonypillai, C., Bulugahapitiya, D., Medagama, U., Huang, C., Lu, Y., Hwang, J., Chiang, C., Wen, M., Chen, J., Lai, W., Chang, K., Wang, J., Yeh, H., Kriangsak, P., Deerochanawong, C., Suwanwalaikorn, S., Mangklabruks, A., Kaewsuwanna, P., Piyayotai, D., Iabluchanskyi, M., Samoylov, O., Godlevska, O., Kovalyova, O., Voloshyna, O., Tseluyko, V., Zotov, S., Vykhovanyuk, I., Dulgeroff, A., Mayfield, R., Zaniewski-Singh, M., Ullal, J., Aloi, J., De La Rosa, R., Mosely, J., Wittmer, B., Aronoff, S., Rosenfeld, J., Seidner, M., Warren, M., Fishman, N., Weiss, R., Arif, A., Sandberg, M., Lewis, D., Ball, E., Graf, R., Breton, C., Tamayo, R., Richards, R., Cefalu, W., Uwaifo, G., Zayour, D., Hoffman, J., Fitz-Patrick, D., Khan, B., Blaze, K., Bressler, P., Halpern, S., Chappell, D., Bergenstal, R., Cuddihy, R., Matfin, G., Freedman, Z., Gonzalez-Campoy, J., Lerman, S., Rendell, M., Sitar, S., Reeves, M., Howard, T., Soufer, J., Miranda-Palma, B., Laliotis, A., Shomali, M., Teltser, M., Hurley, D., Morawski, E., Cherlin, R., Houchin, V., Welch, M., Goytia-Leos, D., Syed, M., Kowaloff, E., Weinrauch, L., Peniston, J., Brockmyre, A., First, B., Feld, L., Huffman, D., Nassim, O., Gottschlich, G., Patel, A., Knopke, C., Hernandez, M., Diaz, J., Giugliano, G., Nicasio, J., Eagerton, D., Huntley, R., Reed, J., Magee, M., Hippert, R., Sofley, C., Alzohaili, O., Levins, P., Anspach, R., Shah, S., Brusco, O., Naidu, J., Lindenbaum, J., Jacks, R., Hammond, G., Arena, C., Saxman, K., Mach, M., Kerstein, H., Kereiakes, D., Wahlen, J., Wehmeier, K., Chaykin, L., Rothman, J., Fogelfeld, L., Stroger, John H., Bittar, N., Rosenstock, J., Kayne, D., Navarro, J., Colfer, H., Mokshagundam, S., Shandilya, L., Connery, L., Wysham, C., Dela Llana, A., Jardula, M., MacAdams, M., Flippo, G., Heurich, E., Curtis, C., Sanders, D., Rawls, R., Velazquez, F., Osea, E., Mahood, K., Feldman, G., Eder, F., Riley, E., Fowler, W., Jain, M., Shepard, M., Schear, M., Barker, B., Strout, C., Obiekwe, O., Shanik, M., Green, C., Blakney, E., Roberson, K., Bretton, E., Pish, R., Kaveh, K., Maynard, B., Barager, W., Soldyshev, R., Austin, B., Parmar, P., Simpson, R., Chauhan, A., Kasper, J., Burr, R., Patel, N., Mariano, H., Pluto, T., Bratcher, C., Juarez, M., Levinson, L., Awad, A., Longshaw, K., Hoffman, K., Richwine, R., Molter, D., Boscia, J., Kowalyk, S., Lemis, P., Liss, J., Orr, R., Riser, J., Wood, J., Ubani, A., Paine, W., Hassani, F., Miranda, F., Hansen, V., Hansen, Val R., Farris, N., Bowden, R., Ajani, D., Maw, K., Andersen, J., Bergman, B., Dunmyer, S., Brandon, D., Anderson, M., Bononi, P., Prawer, J., Seidman, B., Cruz, H., Wilks, K., DiSanto, L., Buynak, R., Christensen, T., Denker, P., Koppel, W., Stedman, M., Lewy-Alterbaum, L., Karim, S., Shapiro, J., Gardner, T., Oskin, T., Gabra, N., Malano, J., Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Groningen Kidney Center (GKC), Methods in Medicines evaluation & Outcomes research (M2O), and EMPA-REG OUTCOME Investigators
Subjects: Male, Placebo-controlled study, PROGRESSION, Type 2 diabetes, 030204 cardiovascular system & hematology, PLACEBO-CONTROLLED TRIAL, GLOMERULAR-FILTRATION-RATE, HYPERFILTRATION, law.invention, ESTABLISHED CARDIOVASCULAR-DISEASE, Cohort Studies, MELLITUS, 0302 clinical medicine, Randomized controlled trial, Glucosides, law, Medicine, Diabetic Nephropathies, GFR DECLINE, General Medicine, Middle Aged, Nephrology, diabetes mellitus, randomized controlled trials, Disease Progression, Female, Glomerular Filtration Rate, medicine.medical_specialty, Urology, Renal function, 030209 endocrinology & metabolism, Placebo, 03 medical and health sciences, Double-Blind Method, Clinical Research, Diabetes mellitus, BASE-LINE CHARACTERISTICS, END-POINTS, Empagliflozin, Humans, Benzhydryl Compounds, Sodium-Glucose Transporter 2 Inhibitors, Aged, COTRANSPORTER 2 INHIBITION, Models, Statistical, Dose-Response Relationship, Drug, business.industry, chronic kidney disease, medicine.disease, Confidence interval, Diabetes Mellitus, Type 2, Human medicine, business
Abstract: BACKGROUND: Empagliflozin slowed the progression of CKD in patients with type 2 diabetes and cardiovascular disease in the EMPA-REG OUTCOME Trial. In a prespecified statistical approach, we assessed treatment differences in kidney function by analyzing slopes of eGFR changes.METHODS: Participants (n=7020) were randomized (1:1:1) to empagliflozin 10 mg/d, empagliflozin 25 mg/d, or placebo added to standard of care. We calculated eGFR slopes using random-intercept/random-coefficient models for prespecified study periods: treatment initiation (baseline to week 4), chronic maintenance treatment (week 4 to last value on treatment), and post-treatment (last value on treatment to follow-up).RESULTS: Compared with placebo, empagliflozin was associated with uniform shifts in individual eGFR slopes across all periods. On treatment initiation, adjusted mean slope (eGFR change per week, ml/min per 1.73 m2) decreased with empagliflozin (-0.77; 95% confidence interval, -0.83 to -0.71; placebo: 0.01; 95% confidence interval, -0.08 to 0.10; PCONCLUSIONS: The hemodynamic effects of empagliflozin, associated with reduction in intraglomerular pressure, may contribute to long-term preservation of kidney function.
Published: 2018

31. Mushrooms and Other Fungi of the Midcontinental United States

Author: Huffman, D. M., Tiffany, L. H., Knaphus, G., Healy, R. A., Huffman, D. M., Tiffany, L. H., Knaphus, G., and Healy, R. A.
Published: 2008

32. Empagliflozin and Cerebrovascular Events in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk

Author: Zinman, Bernard, Inzucchi, Silvio E., Lachin, John M., Wanner, Christoph, Fitchett, David, Kohler, Sven, Mattheus, Michaela, Biomath, Dipl, Woerle, Hans J., Broedl, Uli C., Johansen, Odd Erik, Albers, Gregory W., Diener, Hans Christoph, Aizenberg, D., Ulla, M., Waitman, J., De Loredo, L., Farias, J., Fideleff, H., Lagrutta, M., Maldonado, N., Colombo, H., Ferre Pacora, F., Wasserman, A., Maffei, L., Lehman, R., Selvanayagam, J., d'Emden, M., Fasching, P., Paulweber, B., Toplak, H., Luger, A., Drexel, H., Prager, R., Schnack, C., Schernthaner, G., Fliesser-Goerzer, E., Kaser, S., Scheen, A., Van Gaal, L., Hollanders, G., Kockaerts, Y., Capiau, L., Chachati, A., Persu, A., Hermans, M., Vantroyen, D., Vercammen, C., Van de Borne, P., Mathieu, C., Benhalima, K., Lienart, F., Mortelmans, J., Strivay, M., Vereecken, G., Keymeulen, B., Lamkanfi, F., Chacra, A., Eliaschewitz, F., Zanella, M., Faludi, A., Bertolami, M., Hayashida, C., Nunes Salles, J., Monte, O., Dinato, M., Manenti, E., Rassi, N., Halpern, A., Lima Filho, M., Ayoub, J., Felicio, J., Borges, J., Gross, J., Sgarbi, J., Betti, R., Tiburcio, A., Purisch, S., Schmid, H., Takahashi, M., Castro, M., Rea, R., Hissa, M., Geloneze Neto, B., Saraiva, J., Henein, S., Lochnan, H., Imran, S. A., Clayton, D., Bayly, K., Berlingieri, J., Boucher, P., Chan, Y., Gupta, M., Chehayeb, R., Ouellett, A., Ur, E., Woo, V., Zinman, B., St Amour, E., Terront Lozano, M., Yupanqui Lozno, H., Urina, M., Lopez Jaramillo, P., Jaramillo, N., Sanchez, G., Perez, G., Tusek, S., Mirosevic, G., Goldoni, V., Jurisic-Erzen, D., Balasko, A., Balic, S., Drvodelic-Sunic, E., Varzic, S. Canecki, Machkova, M., Weiner, P., Lastuvka, J., Olsovsky, J., Krarup, T., Ridderstrale, M., Tarnow, L., Boesgaard, T. Wellov, Lihn, A. Saetre, Christensen, P., Juhl, H., Urhammer, S., Lund, P., Adojaan, B., Jakovlev, U., Lanno, R., Lubi, M., Marandi, T., Gouet, D., Courreges, J., Zaoui, P., Choukroun, G., Petit, C., Formagne, L., Estour, B., Mabire, P., Daugenet, C., Lemarie, B., Clavel, S., Aure, P., Remaud, P., Halimi, J., Hadjadj, S., Couffinhal, T., Glonti, S., Metreveli, D., Lominadze, Z., Giorgadze, E., Burtchuladze, T., Javashvili, L., Kurashvili, G., Kurashvili, R., Virsaladze, D., Nadareishvili, L., Khomasuridze, A., Cahill, T., Green, F., MacRury, S., Waldron, M., Middleton, A., McKnight, J., Pearson, E., Butler, M., Choksi, M., Caldwell, I., Farmer, I., Wyatt, N., Patrick, J., O'Brien, I., Devers, M., Bousboulas, S., Pappas, S., Piaditis, G., Vryonidou, A., Tentolouris, N., Karamitsos, K., Manes, C., Benroubi, M., Avramidis, I., Ozaki, R., Tan, K., Siu, S., Tsang, C., Dudas, M., Nagy, K., Salamon, C., Ip, T., Geroo, L., Patkay, J., Tabak, A., Juhasz, F., Szentpeteri, I., Tamas, G., Ghaisas, N., Bantwal, G., Mohan, V., Gupta, J., Sadhu, N., Kulkarni, A., Garg, N., Reddy, S., Deshpande, N., Gutlapalli, K., Pillai, M., Premchand, R., Badgandi, M., Jain, S., Aravind, S., Shamanna, P., Pandey, A., Gupta, S., Pramono, B., Saksono, H. Dante, Agung, P., Wahono, S. Djoko, Suastika, K., Tanggo, Y., Juwana, Y., Siswanto, B., Adawi, F., Efrati, S., Mazen, E., Bashkin, A., Herskovits, T., Jaffe, A., Schiff, E., Wainstein, J., Taddei, S., Aiello, A., Arca, M., Calabro, P., Cignarelli, M., Fioretto, P., Reggiani, G. Marchesini, Gnasso, A., Marchionni, N., Marsilii, A., Bucci, M., Mezzetti, A., Pozzilli, P., Colivicchi, F., Santini, M., Moro, E., Toscano, V., Fucili, A., Semplicini, A., Monno, S., Furui, K., Higashiue, S., Hiramatsu, N., Kawamitsu, K., Takenaka, T., Takahashi, H., Hojo, F., Onishi, Y., Izumino, K., Okubo, M., Wakida, Y., Kondo, Y., Hieshima, K., Jinnouchi, H., Suzuki, A., Ito, M., Park, S., Kim, Y., Hong, T., Park, H., Gwon, H., Kim, H., Kang, K., Jeong, M., Seung, K., Lim, D., Rha, S., Tahk, S., Yang, J., Yoon, J., Shin, M., Kim, D., Jeong, J., Ahmad, N. Nik, Mustafa, N., Mohamed, W. Wan, Fung, Y., Ghani, R. Abdul, Chandramouli, A., Chee, K., Kadir, K. Abdul, Ling, K., Abu Hassan, M., Foo, S., Lee, S., Garcia Hernandez, P., Aguilar-Salinas, C., Vidrio Velazquez, M., Flores, F., Alpizar Salazar, M., Micher Escalante, D., Garcia Soria, M., Cardona Munoz, E., Storms, G., Schaper, N., Kooy, A., Krekels, M., van Bemmel, T., Verhoeven, R., Mulder, H., Oldenburg-Ligtenberg, P., Gonkel, F., de Jong, A., van Soest, J., Viergever, P., Mevissen, H., Lochorn, G., Zwiers, G., Hoogslag, P., Ronner, E., Nierop, P., Al-Windy, N., Kragten, J., Dekelver, P., Benatar, J., Krebs, J., Scott, R., Heggen, E., Berz, A., Fossum, C., Hurtig, U., Langslet, G., Baranowski, M., Sparby, J., Karlsson, T., Karlsson, Thomas, Delgado Torres, C., Rodriguez Escudero, A., Lisson, R., Allemant Maldonado, A., Gallardo Rojas, W., Gonzales Bravo, L., Lema Osores, J., Farfan, J., Zapata, L., Godoy Junchaya, J., Roldan Concha, Y., Urquiaga Calderon, J., Sy, R., Tan, G., Aquitania, G., De Los Santos, G., Panelo, A., Roderos, O., Rosales, R., Toledo, R., Liwag, A., Ramoncito, H., Skokowska, E., Krzyzagorska, E., Ogorek, M., Wojnowski, L., Spyra, J., Konieczny, M., Piesiewicz, W., Kus, W., Ocicka-Kozakiewicz, A., Orlowska-Kunikowska, E., Zmuda, W., Duarte, S., Leitao, A., Monteiro, P., Rita, H., Salgado, V., Pinto, L., Queiros, J., Teixeira, J., Rogado, C., Duarte, R., Sobral do Rosario, F., Silva, A., Andrade, L., Velez, M., Brazao, M., Istratoaie, O., Lichiardopol, R., Catrinoiu, D., Militaru, C., Zetu, C., Barbonta, D., Cosma, D., Crisan, C., Pop, L., Esip, V., Khetagurova, F., Petrov, A., Arutyunov, G., Boyarkin, M., Agafyina, A., Vorokhobina, N., Petunina, N., Libov, I., Zalevskaya, A., Nikolaev, K., Barbarash, O., Potemkin, V., Bystrova, A., Krasilnikova, E., Barbarich, V., Chumakova, G., Tarasov, N., Meleshkevich, T., Zateyshchikov, D., Lantseva, O., Belenkiy, D., Obrezan, A., Rossolko, L., Fillipova, E., Yakhontova, P., Khokhlov, A., Tan, R., Sum, C., Chang, H., Distiller, L., Pretorius, M., Nortje, H., Mitha, E., Burgess, L., Blignaut, S., Venter, T., Moodley, R., Lombaard, J., Govind, U., Naidoo, V., Mookadam, M., Engelbrecht, J., Omar, M., Jurgens, J., Podgorski, G., Vawda, H., Naidoo, D., Emanuel, S., Roodt, A., Amod, A., Van Zyl, L., Segura, J., Brito, M., Fernandez-Cruz, A., Artola, S., Iglesias, R., Toural, E., Garcia-Ortiz, L., Saban, J., Mesa, J., Vidal, J., Linares, J., del Canizo, F., Rigla, M., Suarez, C., Llorente, I., Moreno, B., Antoli, A., Gomez Peralta, F., Iglesias, M., Pereg, V., de Teresa, L., Camafort, M., Trescoli, C., Satarasinghe, R., Somasundaram, N., Siyambalapitiya, S., Antonypillai, C., Bulugahapitiya, D., Medagama, U., Huang, C., Lu, Y., Hwang, J., Chiang, C., Wen, M., Chen, J., Lai, W., Chang, K., Wang, J., Yeh, H., Kriangsak, P., Deerochanawong, C., Suwanwalaikorn, S., Mangklabruks, A., Kaewsuwanna, P., Piyayotai, D., Iabluchanskyi, M., Samoylov, O., Godlevska, O., Kovalyova, O., Voloshyna, O., Tseluyko, V., Zotov, S., Vykhovanyuk, I., Dulgeroff, A., Mayfield, R., Zaniewski-Singh, M., Ullal, J., Aloi, J., De La Rosa, R., Mosely, J., Wittmer, B., Aronoff, S., Rosenfeld, J., Seidner, M., Warren, M., Fishman, N., Weiss, R., Arif, A., Sandberg, M., Lewis, D., Ball, E., Graf, R., Breton, C., Tamayo, R., Richards, R., Cefalu, W., Uwaifo, G., Zayour, D., Hoffman, J., Fitz-Patrick, D., Khan, B., Blaze, K., Bressler, P., Halpern, S., Chappell, D., Bergenstal, R., Cuddihy, R., Matfin, G., Freedman, Z., Gonzalez-Campoy, J., Lerman, S., Rendell, M., Sitar, S., Reeves, M., Howard, T., Soufer, J., Miranda-Palma, B., Laliotis, A., Shomali, M., Teltser, M., Hurley, D., Morawski, E., Cherlin, R., Houchin, V., Welch, M., Goytia-Leos, D., Syed, M., Kowaloff, E., Weinrauch, L., Peniston, J., Brockmyre, A., First, B., Feld, L., Huffman, D., Nassim, O., Gottschlich, G., Patel, A., Knopke, C., Hernandez, M., Diaz, J., Giugliano, G., Nicasio, J., Eagerton, D., Huntley, R., Reed, J., III, Magee, M., Hippert, R., Sofley, C., Jr., Alzohaili, O., Levins, P., Anspach, R., Shah, S., Brusco, O., Naidu, J., Lindenbaum, J., Jacks, R., Hammond, G., Arena, C., Saxman, K., Mach, M., Kerstein, H., Kereiakes, D., Wahlen, J., Wehmeier, K., Chaykin, L., Rothman, J., Fogelfeld, L., Stroger, John H., Jr., Bittar, N., Rosenstock, J., Kayne, D., Navarro, J., Colfer, H., Mokshagundam, S., Shandilya, L., Connery, L., Wysham, C., Dela Llana, A., Jardula, M., MacAdams, M., Flippo, G., Heurich, E., Curtis, C., Sanders, D., Rawls, R., Velazquez, F., Osea, E., Mahood, K., Feldman, G., Eder, F., Riley, E., Fowler, W., Jain, M., Shepard, M., Schear, M., Barker, B., Strout, C., Obiekwe, O., Shanik, M., Green, C., Blakney, E., Roberson, K., Bretton, E., Pish, R., Kaveh, K., Maynard, B., Barager, W., Soldyshev, R., Austin, B., Parmar, P., Simpson, R., Chauhan, A., Kasper, J., Burr, R., Patel, N., Mariano, H., Pluto, T., Bratcher, C., Juarez, M., Levinson, L., Awad, A., Longshaw, K., Hoffman, K., Richwine, R., Molter, D., Boscia, J., III, Kowalyk, S., Lemis, P., Liss, J., Orr, R., Riser, J., Wood, J., Ubani, A., Paine, W., Hassani, F., Miranda, F., Hansen, V., Hansen, Val R., Farris, N., Bowden, R., Ajani, D., Maw, K., Andersen, J., Bergman, B., Dunmyer, S., Brandon, D., Anderson, M., Bononi, P., Prawer, J., Seidman, B., Cruz, H., Wilks, K., DiSanto, L., Buynak, R., Christensen, T., Denker, P., Koppel, W., Stedman, M., Lewy-Alterbaum, L., Karim, S., Shapiro, J., Gardner, T., Oskin, T., Gabra, N., Malano, J., and EMPA REG OUTCOME Investigators
Subjects: riesgo, compuestos de bencidrilo, type 2 diabetes mellitus, Original Contributions, humanos, Medizin, 030204 cardiovascular system & hematology, blood pressure, cardiovascular diseases, hematocrit, stroke, 0302 clinical medicine, Glucosides, glucósidos, 030212 general & internal medicine, Myocardial infarction, Stroke, mediana edad, anciano, OUTCOMES, Hazard ratio, Middle Aged, ISCHEMIC-STROKE, Anesthesia, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Cardiology, TRIAL, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Risk, medicine.medical_specialty, Clinical Sciences, enfermedades cardiovasculares, Clinical Neurology, Placebo, 03 medical and health sciences, Outcome Assessment (Health Care), Internal medicine, medicine, Empagliflozin, Diabetes Mellitus, Humans, Hypoglycemic Agents, accidente cerebrovascular, Benzhydryl Compounds, METAANALYSIS, Aged, Advanced and Specialized Nursing, Science & Technology, business.industry, MORTALITY, Type 2 Diabetes Mellitus, medicine.disease, Confidence interval, Blood pressure, hipoglicemiantes, Peripheral Vascular Disease, evaluación de resultados (asistencia sanitaria), Cardiovascular System & Cardiology, Neurology (clinical), Neurosciences & Neurology, business, FOLLOW-UP
Abstract: Supplemental Digital Content is available in the text., Background and Purpose— In the EMPA-REG OUTCOME trial (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients), empagliflozin added to standard of care in patients with type 2 diabetes mellitus and high cardiovascular risk reduced the risk of 3-point major adverse cardiovascular events, driven by a reduction in cardiovascular mortality, with no significant difference between empagliflozin and placebo in risk of myocardial infarction or stroke. In a modified intent-to-treat analysis, the hazard ratio for stroke was 1.18 (95% confidence interval, 0.89–1.56; P=0.26). We further investigated cerebrovascular events. Methods— Patients were randomized to empagliflozin 10 mg, empagliflozin 25 mg, or placebo; 7020 patients were treated. Median observation time was 3.1 years. Results— The numeric difference in stroke between empagliflozin and placebo in the modified intent-to-treat analysis was primarily because of 18 patients in the empagliflozin group with a first event >90 days after last intake of study drug (versus 3 on placebo). In a sensitivity analysis based on events during treatment or ≤90 days after last dose of drug, the hazard ratio for stroke with empagliflozin versus placebo was 1.08 (95% confidence interval, 0.81–1.45; P=0.60). There were no differences in risk of recurrent, fatal, or disabling strokes, or transient ischemic attack, with empagliflozin versus placebo. Patients with the largest increases in hematocrit or largest decreases in systolic blood pressure did not have an increased risk of stroke. Conclusions— In patients with type 2 diabetes mellitus and high cardiovascular risk, there was no significant difference in the risk of cerebrovascular events with empagliflozin versus placebo. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01131676.
Published: 2017

33. TARGETING GROWTH FACTOR SIGNALING TO DELAY AGING

Author: Huffman, D, primary
Published: 2018
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34. 0222 Automated Selective REM Sleep Restriction Through Non-invasive Somatosensory Stimulation

Author: Huffman, D, primary, Ajwad, A, additional, Agarwal, A, additional, O’Hara, B, additional, Donohue, K, additional, and Sunderam, S, additional
Published: 2018
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35. 0309 Evaluation of Wake, REM, and NREM State Classifiers using Noninvasive Piezoelectric Sensors for Rodents

Author: Agarwal, A, primary, Donohue, K D, additional, Lhamon, M E, additional, Huffman, D M, additional, Bernat, R L, additional, Wang, H, additional, Ajwad, A, additional, Wang, C, additional, Guerriero, L, additional, Sunderam, S, additional, and O’HARA, B F, additional
Published: 2018
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36. 0129 Non-pharmacological Regulation Of The Ultradian Sleep-wake Cycle In Mice

Author: Ajwad, A A, primary, Huffman, D, additional, Wang, H, additional, O’Hara, B, additional, and Sunderam, S, additional
Published: 2018
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37. Methods and Difficulties in Laboratory Studies of Cosmic Dust Analogues

Author: Huffman, D. R., Bussoletti, Ezio, editor, Fusco, Carlo, editor, and Longo, Giuseppe, editor
Published: 1988
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38. SODIUM METAPHOSPHATE AND MUTTON TENDERNESS

Author: Huffman, D. L., Palmer, A. Z., Carpenter, J. W., and Shirley, R. L.
Published: 1965

39. Phosphorus Removal by Luxury Uptake

Author: Mulbarger, M. C., Shifflett, D. G., Murphy, M. C., and Huffman, D. D.
Published: 1971

40. SARCOSINE IS UNIQUELY MODULATED BY AGING AND DIETARY RESTRICTION IN RODENTS AND HUMANS

Author: Walters, R.O., Fontana, L., Kurland, I., Diaz, A., Arias-Perez, E., Cuervo, A., Promislow, D., and Huffman, D.
Subjects: Abstracts, Health (social science), food and beverages, sense organs, Life-span and Life-course Studies, Health Professions (miscellaneous)
Abstract: A hallmark of aging is a decline in metabolic homeostasis, and these adverse changes can be attenuated by dietary restriction (DR). However, the impact of aging, DR and their interaction on the metabolome, is not clear.
Published: 2017
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41. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME (R) trial

Author: Fitchett, David, Zinman, Bernard, Wanner, Christoph, Lachin, John M., Hantel, Stefan, Salsali, Afshin, Johansen, Odd Erik, Woerle, Hans J., Broedl, Uli C., Inzucchi, Silvio E., Aizenberg, D., Ulla, M., Waitman, J., De Loredo, L., Farias, J., Fideleff, H., Lagrutta, M., Maldonado, N., Colombo, H., Ferre Pacora, F., Wasserman, A., Maffei, L., Lehman, R., Selvanayagam, J., d'Emden, M., Fasching, P., Paulweber, B., Toplak, H., Luger, A., Drexel, H., Prager, R., Schnack, C., Schernthaner, G., Fliesser-Goerzer, E., Kaser, S., Scheen, A., Van Gaal, L., Hollanders, G., Kockaerts, Y., Capiau, L., Chachati, A., Persu, A., Hermans, M., Vantroyen, D., Vercammen, C., Van de Borne, P., Mathieu, C., Benhalima, K., Lienart, F., Mortelmans, J., Strivay, M., Vereecken, G., Keymeulen, B., Lamkanfi, F., Chacra, A., Eliaschewitz, F., Zanella, M., Faludi, A., Bertolami, M., Hayashida, C., Nunes Salles, J., Monte, O., Dinato, M., Manenti, E., Rassi, N., Halpern, A., Lima Filho, M., Ayoub, J., Felicio, J., Borges, J., Gross, J., Sgarbi, J., Betti, R., Tiburcio, A., Purisch, S., Schmid, H., Takahashi, M., Castro, M., Rea, R., Hissa, M., Geloneze Neto, B., Saraiva, J., Henein, S., Lochnan, H., Imran, S. A., Clayton, D., Bayly, K., Berlingieri, J., Boucher, P., Chan, Y., Gupta, M., Chehayeb, R., Ouellett, A., Ur, E., Woo, V., Zinman, B., St Amour, E., Terront Lozano, M., Yupanqui Lozno, H., Urina, M., Lopez Jaramillo, P., Jaramillo, N., Sanchez, G., Perez, G., Tusek, S., Mirosevic, G., Goldoni, V., Jurisic-Erzen, D., Balasko, A., Balic, S., Drvodelic-Sunic, E., Varzic, S. Canecki, Machkova, M., Weiner, P., Lastuvka, J., Olsovsky, J., Krarup, T., Ridderstrale, M., Tarnow, L., Boesgaard, T. Wellov, Lihn, A. Saetre, Christensen, P., Juhl, H., Urhammer, S., Lund, P., Adojaan, B., Jakovlev, U., Lanno, R., Lubi, M., Marandi, T., Gouet, D., Courreges, J., Zaoui, P., Choukroun, G., Petit, C., Formagne, L., Estour, B., Mabire, P., Daugenet, C., Lemarie, B., Clavel, S., Aure, P., Remaud, P., Halimi, J., Hadjadj, S., Couffinhal, T., Glonti, S., Metreveli, D., Lominadze, Z., Giorgadze, E., Burtchuladze, T., Javashvili, L., Kurashvili, G., Kurashvili, R., Virsaladze, D., Nadareishvili, L., Khomasuridze, A., Cahill, T., Green, F., MacRury, S., Waldron, M., Middleton, A., McKnight, J., Pearson, E., Butler, M., Choksi, M., Caldwell, I., Farmer, I., Wyatt, N., Patrick, J., O'Brien, I., Devers, M., Bousboulas, S., Pappas, S., Piaditis, G., Vryonidou, A., Tentolouris, N., Karamitsos, K., Manes, C., Benroubi, M., Avramidis, I., Ozaki, R., Tan, K., Siu, S., Tsang, C., Dudas, M., Nagy, K., Salamon, C., Ip, T., Geroo, L., Patkay, J., Tabak, A., Juhasz, F., Szentpeteri, I., Tamas, G., Ghaisas, N., Bantwal, G., Mohan, V., Gupta, J., Sadhu, N., Kulkarni, A., Garg, N., Reddy, S., Deshpande, N., Gutlapalli, K., Pillai, M., Premchand, R., Badgandi, M., Jain, S., Aravind, S., Shamanna, P., Pandey, A., Gupta, S., Pramono, B., Saksono, H. Dante, Agung, P., Wahono, S. Djoko, Suastika, K., Tanggo, Y., Juwana, Y., Siswanto, B., Adawi, F., Efrati, S., Mazen, E., Bashkin, A., Herskovits, T., Jaffe, A., Schiff, E., Wainstein, J., Taddei, S., Aiello, A., Arca, M., Calabro, P., Cignarelli, M., Fioretto, P., Reggiani, G. Marchesini, Gnasso, A., Marchionni, N., Marsilii, A., Bucci, M., Mezzetti, A., Pozzilli, P., Colivicchi, F., Santini, M., Moro, E., Toscano, V., Fucili, A., Semplicini, A., Monno, S., Furui, K., Higashiue, S., Hiramatsu, N., Kawamitsu, K., Takenaka, T., Takahashi, H., Hojo, F., Onishi, Y., Izumino, K., Okubo, M., Wakida, Y., Kondo, Y., Hieshima, K., Jinnouchi, H., Suzuki, A., Ito, M., Park, S., Kim, Y., Hong, T., Park, H., Gwon, H., Kim, H., Kang, K., Jeong, M., Seung, K., Lim, D., Rha, S., Tahk, S., Yang, J., Yoon, J., Shin, M., Kim, D., Jeong, J., Ahmad, N. Nik, Mustafa, N., Mohamed, W. Wan, Fung, Y., Ghani, R. Abdul, Chandramouli, A., Chee, K., Kadir, K. Abdul, Ling, K., Abu Hassan, M., Foo, S., Lee, S., Garcia Hernandez, P., Aguilar-Salinas, C., Vidrio Velazquez, M., Flores, F., Alpizar Salazar, M., Micher Escalante, D., Garcia Soria, M., Cardona Munoz, E., Storms, G., Schaper, N., Kooy, A., Krekels, M., van Bemmel, T., Verhoeven, R., Mulder, H., Oldenburg-Ligtenberg, P., Gonkel, F., de Jong, A., van Soest, J., Viergever, P., Mevissen, H., Lochorn, G., Zwiers, G., Hoogslag, P., Ronner, E., Nierop, P., Al-Windy, N., Kragten, J., Dekelver, P., Benatar, J., Krebs, J., Scott, R., Heggen, E., Berz, A., Fossum, C., Hurtig, U., Langslet, G., Baranowski, M., Sparby, J., Karlsson, T., Karlsson, Thomas, Delgado Torres, C., Rodriguez Escudero, A., Lisson, R., Allemant Maldonado, A., Gallardo Rojas, W., Gonzales Bravo, L., Lema Osores, J., Farfan, J., Zapata, L., Godoy Junchaya, J., Roldan Concha, Y., Urquiaga Calderon, J., Sy, R., Tan, G., Aquitania, G., De Los Santos, G., Panelo, A., Roderos, O., Rosales, R., Toledo, R., Liwag, A., Ramoncito, H., Skokowska, E., Krzyzagorska, E., Ogorek, M., Wojnowski, L., Spyra, J., Konieczny, M., Piesiewicz, W., Kus, W., Ocicka-Kozakiewicz, A., Orlowska-Kunikowska, E., Zmuda, W., Duarte, S., Leitao, A., Monteiro, P., Rita, H., Salgado, V., Pinto, L., Queiros, J., Teixeira, J., Rogado, C., Duarte, R., Sobral do Rosario, F., Silva, A., Andrade, L., Velez, M., Brazao, M., Istratoaie, O., Lichiardopol, R., Catrinoiu, D., Militaru, C., Zetu, C., Barbonta, D., Cosma, D., Crisan, C., Pop, L., Esip, V., Khetagurova, F., Petrov, A., Arutyunov, G., Boyarkin, M., Agafyina, A., Vorokhobina, N., Petunina, N., Libov, I., Zalevskaya, A., Nikolaev, K., Barbarash, O., Potemkin, V., Bystrova, A., Krasilnikova, E., Barbarich, V., Chumakova, G., Tarasov, N., Meleshkevich, T., Zateyshchikov, D., Lantseva, O., Belenkiy, D., Obrezan, A., Rossolko, L., Fillipova, E., Yakhontova, P., Khokhlov, A., Tan, R., Sum, C., Chang, H., Distiller, L., Pretorius, M., Nortje, H., Mitha, E., Burgess, L., Blignaut, S., Venter, T., Moodley, R., Lombaard, J., Govind, U., Naidoo, V., Mookadam, M., Engelbrecht, J., Omar, M., Jurgens, J., Podgorski, G., Vawda, H., Naidoo, D., Emanuel, S., Roodt, A., Amod, A., Van Zyl, L., Segura, J., Brito, M., Fernandez-Cruz, A., Artola, S., Iglesias, R., Toural, E., Garcia-Ortiz, L., Saban, J., Mesa, J., Vidal, J., Linares, J., del Canizo, F., Rigla, M., Suarez, C., Llorente, I., Moreno, B., Antoli, A., Gomez Peralta, F., Iglesias, M., Pereg, V., de Teresa, L., Camafort, M., Trescoli, C., Satarasinghe, R., Somasundaram, N., Siyambalapitiya, S., Antonypillai, C., Bulugahapitiya, D., Medagama, U., Huang, C., Lu, Y., Hwang, J., Chiang, C., Wen, M., Chen, J., Lai, W., Chang, K., Wang, J., Yeh, H., Kriangsak, P., Deerochanawong, C., Suwanwalaikorn, S., Mangklabruks, A., Kaewsuwanna, P., Piyayotai, D., Iabluchanskyi, M., Samoylov, O., Godlevska, O., Kovalyova, O., Voloshyna, O., Tseluyko, V., Zotov, S., Vykhovanyuk, I., Dulgeroff, A., Mayfield, R., Zaniewski-Singh, M., Ullal, J., Aloi, J., De La Rosa, R., Mosely, J., Wittmer, B., Aronoff, S., Rosenfeld, J., Seidner, M., Warren, M., Fishman, N., Weiss, R., Arif, A., Sandberg, M., Lewis, D., Ball, E., Graf, R., Breton, C., Tamayo, R., Richards, R., Cefalu, W., Uwaifo, G., Zayour, D., Hoffman, J., Fitz-Patrick, D., Khan, B., Blaze, K., Bressler, P., Halpern, S., Chappell, D., Bergenstal, R., Cuddihy, R., Matfin, G., Freedman, Z., Gonzalez-Campoy, J., Lerman, S., Rendell, M., Sitar, S., Reeves, M., Howard, T., Soufer, J., Miranda-Palma, B., Laliotis, A., Shomali, M., Teltser, M., Hurley, D., Morawski, E., Cherlin, R., Houchin, V., Welch, M., Goytia-Leos, D., Syed, M., Kowaloff, E., Weinrauch, L., Peniston, J., Brockmyre, A., First, B., Feld, L., Huffman, D., Nassim, O., Gottschlich, G., Patel, A., Knopke, C., Hernandez, M., Diaz, J., Giugliano, G., Nicasio, J., Eagerton, D., Huntley, R., Reed, J., III, Magee, M., Hippert, R., Sofley, C., Jr., Alzohaili, O., Levins, P., Anspach, R., Shah, S., Brusco, O., Naidu, J., Lindenbaum, J., Jacks, R., Hammond, G., Arena, C., Saxman, K., Mach, M., Kerstein, H., Kereiakes, D., Wahlen, J., Wehmeier, K., Chaykin, L., Rothman, J., Fogelfeld, L., Stroger, John H., Jr., Bittar, N., Rosenstock, J., Kayne, D., Navarro, J., Colfer, H., Mokshagundam, S., Shandilya, L., Connery, L., Wysham, C., Dela Llana, A., Jardula, M., MacAdams, M., Flippo, G., Heurich, E., Curtis, C., Sanders, D., Rawls, R., Velazquez, F., Osea, E., Mahood, K., Feldman, G., Eder, F., Riley, E., Fowler, W., Jain, M., Shepard, M., Schear, M., Barker, B., Strout, C., Obiekwe, O., Shanik, M., Green, C., Blakney, E., Roberson, K., Bretton, E., Pish, R., Kaveh, K., Maynard, B., Barager, W., Soldyshev, R., Austin, B., Parmar, P., Simpson, R., Chauhan, A., Kasper, J., Burr, R., Patel, N., Mariano, H., Pluto, T., Bratcher, C., Juarez, M., Levinson, L., Awad, A., Longshaw, K., Hoffman, K., Richwine, R., Molter, D., Boscia, J., III, Kowalyk, S., Lemis, P., Liss, J., Orr, R., Riser, J., Wood, J., Ubani, A., Paine, W., Hassani, F., Miranda, F., Hansen, V., Hansen, Val R., Farris, N., Bowden, R., Ajani, D., Maw, K., Andersen, J., Bergman, B., Dunmyer, S., Brandon, D., Anderson, M., Bononi, P., Prawer, J., Seidman, B., Cruz, H., Wilks, K., DiSanto, L., Buynak, R., Christensen, T., Denker, P., Koppel, W., Stedman, M., Lewy-Alterbaum, L., Karim, S., Shapiro, J., Gardner, T., Oskin, T., Gabra, N., Malano, J., EMPA-REG OUTCOME Trial, and EMPA-REG OUTCOME(R) trial investigators
Subjects: medicine.medical_specialty, Cardiac & Cardiovascular Systems, Aha Fasttrack, BLOOD-PRESSURE, 030209 endocrinology & metabolism, Cardiovascular disease, Hospitalization, Mortality, Type 2 diabetes, 030204 cardiovascular system & hematology, COLLABORATION, GUIDELINES, DOUBLE-BLIND, MELLITUS, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Empagliflozin, Medicine, ddc:610, Adverse effect, Science & Technology, COTRANSPORTER 2 INHIBITION, business.industry, MORTALITY, Hazard ratio, Heart Failure/Cardiomyopathy, medicine.disease, INSULIN, Editor's Choice, Endocrinology, Blood pressure, DISEASES, SAFETY, Heart failure, Cardiovascular System & Cardiology, Number needed to treat, Cardiology, Fast Track, Cardiology and Cardiovascular Medicine, business, Life Sciences & Biomedicine
Abstract: Aims We previously reported that in the EMPA-REG OUTCOME(R) trial, empagliflozin added to standard of care reduced the risk of 3-point major adverse cardiovascular events, cardiovascular and all-cause death, and hospitalization for heart failure in patients with type 2 diabetes and high cardiovascular risk. We have now further investigated heart failure outcomes in all patients and in subgroups, including patients with or without baseline heart failure. Methods and results Patients were randomized to receive empagliflozin 10 mg, empagliflozin 25 mg, or placebo. Seven thousand and twenty patients were treated; 706 (10.1%) had heart failure at baseline. Heart failure hospitalization or cardiovascular death occurred in a significantly lower percentage of patients treated with empagliflozin [265/4687 patients (5.7%)] than with placebo [198/2333 patients (8.5%)] [hazard ratio, HR: 0.66 (95% confidence interval: 0.55-0.79); P < 0.001], corresponding to a number needed to treat to prevent one heart failure hospitalization or cardiovascular death of 35 over 3 years. Consistent effects of empagliflozin were observed across subgroups defined by baseline characteristics, including patients with vs. without heart failure, and across categories of medications to treat diabetes and/or heart failure. Empagliflozin improved other heart failure outcomes, including hospitalization for or death from heart failure [2.8 vs. 4.5%; HR: 0.61 (0.47-0.79); P < 0.001] and was associated with a reduction in all-cause hospitalization [36.8 vs. 39.6%; HR: 0.89 (0.82-0.96); P = 0.003]. Serious adverse events and adverse events leading to discontinuation were reported by a higher proportion of patients with vs. without heart failure at baseline in both treatment groups, but were no more common with empagliflozin than with placebo. Conclusion In patients with type 2 diabetes and high cardiovascular risk, empagliflozin reduced heart failure hospitalization and cardiovascular death, with a consistent benefit in patients with and without baseline heart failure., This work was supported by Boehringer Ingelheim and Eli Lilly and Company. Boehringer Ingelheim was involved in the design and conduct of the study; collection, analysis, and interpretation of data; and preparation of this manuscript. Eli Lilly's involvement was limited to co-funding of the study. Funding to pay the Open Access publication charges for this article was provided by Boehringer Ingelheim.
Published: 2016

42. INTESTINAL STEM CELL FUNCTION IS IMPAIRED BY EXPOSURE TO AN OLD ENVIRONMENT

Author: Huffman, D., primary and Tabrizian, T., additional
Published: 2017
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43. 0094 SLEEP MODULATION IN CONTROL AND EPILEPTIC MICE THROUGH AMBIENT TEMPERATURE REGULATION

Author: Ajwad, A, primary, Yaghouby, F, additional, Huffman, D, additional, Wang, H, additional, O’Hara, B, additional, and Sunderam, S, additional
Published: 2017
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44. Risk attitudes across the life course

Author: Dohmen, T.J., Falk, Armin, Golsteyn, B.H.H., Huffman, D., Sunde, U., Dohmen, T.J., Falk, Armin, Golsteyn, B.H.H., Huffman, D., and Sunde, U.
Abstract: This article investigates how risk attitudes change over the life course. We study the age trajectory of risk attitudes all the way from early adulthood until old age, in large representative panel data sets from the Netherlands and Germany. Age patterns are generally difficult to identify separately from cohort or calendar period effects. We achieve identification by replacing calendar period indicators with controls for the specific underlying factors that may change risk attitudes across periods. The main result is that willingness to take risks decreases over the life course, linearly until approximately age 65 after which the slope becomes flatter.
Published: 2017

45. Design and construction of the MicroBooNE detector

Author: Center for Neutrino Physics, Physics, Acciarri, R., Adams, C., An, R., Aparicio, A., Aponte, S., Asaadi, J., Auger, M., Ayoub, N., Bagby, L., Baller, B., Barger, R., Barr, G., Bass, M., Bay, F., Biery, K., Bishai, M., Blake, A., Bocean, V., Boehnlein, D., Bogert, V. D., Bolton, T., Bugel, L., Callahan, C., Camilleri, Leslie, Caratelli, D., Carls, B., Castillo Fernandez, R., Cavanna, F., Chappa, S., Chen, H., Chen, K., Chi, C. Y., Chiu, C. S., Church, E., Cianci, D., Collin, G. H., Conrad, Janet M., Convery, M., Cornele, J., Cowan, P., Crespo-Anadon, J. I., Crutcher, G., Darve, C., Davis, R., Del Tutto, M., Devitt, D., Duffin, S., Dytman, S., Eberly, B., Ereditato, A., Erickson, D., Escudero Sanchez, L., Esquivel, J., Farooq, S., Farrell, J., Featherston, D., Fleming, B. T., Foreman, W., Furmanski, A. P., Genty, V., Geynisman, M., Goeldi, D., Goff, B., Golapinni, S., Graf, N., Gramellini, E., Green, J., Greene, A., Greenlee, H., Griffin, T., Grosso, R., Guenette, R., Hackenburg, A., Haenni, R., Hamilton, P., Healey, P., Hen, O., Henderson, E., Hewes, J., Hill, C., Hill, K., Himes, L., Ho, J., Horton-Smith, Glenn A., Huffman, D., Ignarra, C. M., James, C., James, E., Jan de Vries, J., Jaskierny, W., Jen, C. M., Jiang, L., Johnson, B., Johnson, M., Johnson, R. A., Jones, B. J. P., Joshi, J., Jostlein, H., Kaleko, D., Kalousis, L. N., Karagiorgi, Georgia S., Katori, T., Kellogg, P., Ketchum, W., Kilmer, J., King, B., Kirby, B., Kirby, M., Klein, E., Kobilarcik, T., Kreslo, I., Krull, R., Kubinski, R., Lange, G., Lanni, F., Lathrop, A., Laube, A., Leeg, W. M., Li, Y., Lissauer, D., Lister, A., Littlejohn, B. R., Lockwitz, S., Lorca, D., Louis, W. C., Lukhanin, G., Luethi, M., Lundberg, B., Luo, X., Mahler, G., Majoros, I., Makowiecki, D., Marchionni, A., Mariani, Camillo, Markley, D., Marshall, J., Martinez Caicedo, D. A., McDonald, K. T., McKee, D., McLean, A., Mead, J., Meddage, V., Miceli, T., Mills, G. B., Miner, W., Moon, J., Mooney, M., Moore, C. D., Moss, Z., Mousseau, J., Murrells, R., Naples, D., Nienaber, P., Norris, B., Norton, N., Nowak, J., O'Boyle, M., Olszanowski, T., Palamara, O., Paolone, V., Papavassiliou, V., Pate, S. F., Pavlovic, Z., Pelkey, R., Phipps, M., Pordes, S., Porzio, D., Pulliam, G., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Rameika, R., Rebel, B., Rechenmacher, R., Rescia, S., Rochester, L., von Rohr, C. R., Ruga, A., Russell, B., Sanders, R., Sands, W. R., Sarychev, M., Schmitz, D. W., Schukraft, A., Scott, R., Seligman, W., Shaevitz, Marjorie Hansen, Shoun, M., Sinclair, J., Sippach, W., Smidt, T., Smith, A., Snider, E. L., Soderberg, M., Solano-Gonzalez, M., Söldner-Rembold, S., Soleti, S. R., Sondericker, J., Spentzouris, P., Spitz, Joshua, St John, J., Strauss, T., Sutton, K., Szelc, A. M., Taheri, K., Tagg, N., Tatum, K., Teng, J., Terao, K., Thomson, M., Thorn, C., Tiliman, J., Toups, M., Tsai, Y. T., Tufanli, S., Usher, T., Utes, M., Van de Water, R. G., Vendetta, C., Vergani, S., Voirin, E., Voirin, J., Viren, B., Watkins, P., Weber, M., Wester, T., Weston, J., Wickremasinghe, D. A., Wolbers, S., Wongjirad, T., Woodruff, K., Wu, K. C., Yang, T., Yu, B., Zeller, Geralyn P., Zennamo, J., Zhang, C., Zuckerbrot, M., Center for Neutrino Physics, Physics, Acciarri, R., Adams, C., An, R., Aparicio, A., Aponte, S., Asaadi, J., Auger, M., Ayoub, N., Bagby, L., Baller, B., Barger, R., Barr, G., Bass, M., Bay, F., Biery, K., Bishai, M., Blake, A., Bocean, V., Boehnlein, D., Bogert, V. D., Bolton, T., Bugel, L., Callahan, C., Camilleri, Leslie, Caratelli, D., Carls, B., Castillo Fernandez, R., Cavanna, F., Chappa, S., Chen, H., Chen, K., Chi, C. Y., Chiu, C. S., Church, E., Cianci, D., Collin, G. H., Conrad, Janet M., Convery, M., Cornele, J., Cowan, P., Crespo-Anadon, J. I., Crutcher, G., Darve, C., Davis, R., Del Tutto, M., Devitt, D., Duffin, S., Dytman, S., Eberly, B., Ereditato, A., Erickson, D., Escudero Sanchez, L., Esquivel, J., Farooq, S., Farrell, J., Featherston, D., Fleming, B. T., Foreman, W., Furmanski, A. P., Genty, V., Geynisman, M., Goeldi, D., Goff, B., Golapinni, S., Graf, N., Gramellini, E., Green, J., Greene, A., Greenlee, H., Griffin, T., Grosso, R., Guenette, R., Hackenburg, A., Haenni, R., Hamilton, P., Healey, P., Hen, O., Henderson, E., Hewes, J., Hill, C., Hill, K., Himes, L., Ho, J., Horton-Smith, Glenn A., Huffman, D., Ignarra, C. M., James, C., James, E., Jan de Vries, J., Jaskierny, W., Jen, C. M., Jiang, L., Johnson, B., Johnson, M., Johnson, R. A., Jones, B. J. P., Joshi, J., Jostlein, H., Kaleko, D., Kalousis, L. N., Karagiorgi, Georgia S., Katori, T., Kellogg, P., Ketchum, W., Kilmer, J., King, B., Kirby, B., Kirby, M., Klein, E., Kobilarcik, T., Kreslo, I., Krull, R., Kubinski, R., Lange, G., Lanni, F., Lathrop, A., Laube, A., Leeg, W. M., Li, Y., Lissauer, D., Lister, A., Littlejohn, B. R., Lockwitz, S., Lorca, D., Louis, W. C., Lukhanin, G., Luethi, M., Lundberg, B., Luo, X., Mahler, G., Majoros, I., Makowiecki, D., Marchionni, A., Mariani, Camillo, Markley, D., Marshall, J., Martinez Caicedo, D. A., McDonald, K. T., McKee, D., McLean, A., Mead, J., Meddage, V., Miceli, T., Mills, G. B., Miner, W., Moon, J., Mooney, M., Moore, C. D., Moss, Z., Mousseau, J., Murrells, R., Naples, D., Nienaber, P., Norris, B., Norton, N., Nowak, J., O'Boyle, M., Olszanowski, T., Palamara, O., Paolone, V., Papavassiliou, V., Pate, S. F., Pavlovic, Z., Pelkey, R., Phipps, M., Pordes, S., Porzio, D., Pulliam, G., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Rameika, R., Rebel, B., Rechenmacher, R., Rescia, S., Rochester, L., von Rohr, C. R., Ruga, A., Russell, B., Sanders, R., Sands, W. R., Sarychev, M., Schmitz, D. W., Schukraft, A., Scott, R., Seligman, W., Shaevitz, Marjorie Hansen, Shoun, M., Sinclair, J., Sippach, W., Smidt, T., Smith, A., Snider, E. L., Soderberg, M., Solano-Gonzalez, M., Söldner-Rembold, S., Soleti, S. R., Sondericker, J., Spentzouris, P., Spitz, Joshua, St John, J., Strauss, T., Sutton, K., Szelc, A. M., Taheri, K., Tagg, N., Tatum, K., Teng, J., Terao, K., Thomson, M., Thorn, C., Tiliman, J., Toups, M., Tsai, Y. T., Tufanli, S., Usher, T., Utes, M., Van de Water, R. G., Vendetta, C., Vergani, S., Voirin, E., Voirin, J., Viren, B., Watkins, P., Weber, M., Wester, T., Weston, J., Wickremasinghe, D. A., Wolbers, S., Wongjirad, T., Woodruff, K., Wu, K. C., Yang, T., Yu, B., Zeller, Geralyn P., Zennamo, J., Zhang, C., and Zuckerbrot, M.
Abstract: This paper describes the design and construction of the MicroBooNE liquid argon time projection chamber and associated systems. MicroBooNE is the first phase of the Short Baseline Neutrino program, located at Fermilab, and will utilize the capabilities of liquid argon detectors to examine a rich assortment of physics topics. In this document details of design specifications, assembly procedures, and acceptance tests are reported.
Published: 2017

46. Misexpression of 50 uncharacterized Drosophila homologs to human disease genes reveals insight into gene function

Author: Huffman, D., Reiter, L.T., and Bier, E.
Subjects: Human genetics -- Research, Genetic disorders -- Research, Biological sciences
Published: 2001

47. Report of the Working Group on Carbon

Author: Huffman, D. R., Bussoletti, Ezio, editor, Fusco, Carlo, editor, and Longo, Giuseppe, editor
Published: 1988
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48. Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes

Author: Gough, S. C., Bode, B., Woo, V., Rodbard, H. W., Linjawi, S., Poulsen, P., Damgaard, L. H., Buse, J. B., NN9068 3697 trial investigators, Donnelly, T, Gerstman, M, Linjawi, S, Park, K, Roberts, A, Shaw, Je, Wu, T, Aggarwal, N, Bowering, K, Chouinard, G, Deyoung, P, Dumas, R, Elliott, Tg, Frechette, A, Giguere, N, Gottesman, I, Ho, K, Kohli, S, Teitelbaum, I, Tytus, R, Wharton, S, Woo, V, Hellsten, T, Kuusela, M, Sarti, C, Strand, J, Valli, K, Erlinger, R, Goelz, S, Hauser, Kh, Hilgenberg, J, Kaiser, M, Marck, C, Merfort, F, Milek, K, Paschen, B, Rose, L, Schlecht, K, Wenzl Bauer, V, Dudas, M, Fulop, G, Harcsa, E, Kerenyi, Z, Szőcs, A, Takacs, R, Babu, T, Bandgar, Tr, Bantwal, G, Bhagwat, Nm, Chatterjee, S, Jain, Sm, John, M, Kale, S, Kanungo, Ak, Kumar, A, Kumar, H, Kumar, Sn, Lodha, S, Majumder, A, Mithal, A, Murthy, S, Sethi, Bk, Shah, P, Sharma, Sk, Sivagnanam, N, Velu, S, Viswanathan, V, Yajnik, Cs, Byrne, M, O'Brien, T, Aimaretti, G, Baroni, Mg, D'Amico, E, Dotta, Francesco, Giordano, C, Sforza, A, Tonolo, G, Bebakar, Wm, Kamaruddin, Na, Hussein, Z, Mumtaz, M, Sothiratnam, R, Gonzalez Galvez, G, Hernandez, Pa, Grineva, E, Kalashnikova, Mf, Kulkova, P, Krasilnikova, Ee, Kondrachenko, S, Kunitsyna, Ma, Poley, M, Sardinov, R, Vorokhobina, Nv, Yurievna, M, Zhdanova, Ea, Zhukova, La, Dalan, R, Khoo, Ey, Sum, Cf, Cizova, M, Martinka, E, Schroner, Z, Teplanova, M, Tomasova, L, Biermann, E, Dulabh, R, Khutsoane, Dt, Komati, Sm, Makan, Ha, Mayet, L, Mitha, Ea, Padayachee, T, Pillay, S, Reddy, J, Snyman, Hh, Siddique, N, Trokis, J, Bobillo, Er, de la Cuesta, C, Fernández, Mr, González, As, De Teresa Parreño, L, Raya, Pm, de la Torre ML, Torres, Jf, Sheu, Wh, Sun, Jh, Yang, Cy, Deerochanawong, C, Phornphutkul, M, Suwanwalaikorn, S, Sriwijitkamol, A, Clark, J, Downie, P, Evans, P, Furlong, N, Gough, S, Harper, R, Harvey, Jn, Khan, A, Leese, G, Mckinnon, C, Narendran, P, Patterson, C, Raymond, F, Singhal, P, Smith, P, Viljoen, A, Willis, T, Acampora, M, Agaiby, Jm, Ahmed, I, Allison, Jr, Altamirano, D, Anderson, Mw, Andrawis, N, Aroda, Vr, Ballard, Tv, Beavins, J, Bedel, Gw, Bernstein, R, Blaze, K, Bode, Bw, Bononi, Pl, Broker, Re, Buse, Jb, Butuk, Dj, Camiscoli, Dj, Canadas, R, Castorino, K, Cathcart, H, Cha, G, Chang, A, Chappel, Cm, Cheema, C, Chenore, M, Cheung, D, Christensen, J, Chu, Jw, Chuck, L, Cohen, Cd, Cohen, K, Cho, Mh, Rivera Colon, L, Condit, J, Corbett, B, Pearlstein, R, Cox, Wr, Daboul, Ny, Deatkine, D, Dunn, Lj, Ellison, Hs, Feldman, Bn, Fidelholtz, J, First, B, Fishman, N, Fogarty, Cm, Fraser, Nj, Gabra, N, Gaona, Re, Gerety, G, Gilman, Rm, Gonte, Ws, Gottschlich, Gm, Grant, Dm, Hewitt, M, Hollander, P, House, Ba, Huffman, D, Jain, Rk, Johnson, G, Jones, Sw, Kayne, Dm, Kimmel, Ma, Klonoff, D, Knight, H, Koontz, D, Kutner, Me, Lenhard, Jm, Liss, Jl, Litchfield, Wr, Lubin, B, Lucas, Kj, Lynn, L, Lyons, Tj, Macadams, Mr, Mach, Mq, Maletz, L, Mariano, Hg, Mayeda, So, Pratley, Re, Madder, R, Martinez, Gj, Mcgarity WC Jr, Mckenzie, Wc, Meisner, Cr, Montenegro, C, Moran, Je, Morawski, Ej, Moretto, Tj, Mudaliar, Sr, Murray, Av, Myers, L, Odugbesan, Ao, Olivarez, E, Pangtay, D, Patel, Mb, Patel, Nr, Patel, R, Perdomo, A, Pritchett, Kl, Rasmussen, B, Reed, Jc, Reeves, Ml, Reichman, A, Rhee, C, Rice, Lc, Risser, J, Rodbard, Hw, Rosen, R, Rosenstock, J, Ryan, Eh, Schreiman, Rc, Scott, Rb, Selagamsetty, Mr, Shaughnessy, J, Silver, R, Simon, Hj, Snyder, B, Soufer, J, Stegemoller, Rk, Sugimoto, D, Thurman, J, Tolia, Kk, Wagner, R, Wahlen, J, Webster, De, Weisbrot, Aj, Whittier, F, Winkle, Pj, Woolley, Jh, Yeoman, G, Zemel, Lr, Smith, Bp, Philis Tsimikas, A, Weissman, P, and Kurland Wise, J.
Subjects: Insulin degludec, Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Urology, Type 2 diabetes, law.invention, Endocrinology, Randomized controlled trial, law, Glucagon-Like Peptide 1, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Glycated Hemoglobin, Liraglutide, business.industry, Insulin, Middle Aged, medicine.disease, Metformin, Insulin, Long-Acting, Drug Combinations, Treatment Outcome, Diabetes Mellitus, Type 2, Female, business, Pioglitazone, medicine.drug
Abstract: A fixed-ratio combination of the basal insulin analogue insulin degludec and the glucagon-like peptide-1 (GLP-1) analogue liraglutide has been developed as a once-daily injection for the treatment of type 2 diabetes. We aimed to compare combined insulin degludec-liraglutide (IDegLira) with its components given alone in insulin-naive patients.In this phase 3, 26-week, open-label, randomised trial, adults with type 2 diabetes, HbA1c of 7-10% (inclusive), a BMI of 40 kg/m(2) or less, and treated with metformin with or without pioglitazone were randomly assigned (2:1:1) to daily injections of IDegLira, insulin degludec, or liraglutide (1·8 mg per day). IDegLira and insulin degludec were titrated to achieve a self-measured prebreakfast plasma glucose concentration of 4-5 mmol/L. The primary endpoint was change in HbA1c after 26 weeks of treatment, and the main objective was to assess the non-inferiority of IDegLira to insulin degludec (with an upper 95% CI margin of 0·3%), and the superiority of IDegLira to liraglutide (with a lower 95% CI margin of 0%). This study is registered with ClinicalTrials.gov, number NCT01336023.1663 adults (mean age 55 years [SD 10], HbA1c 8·3% [0·9], and BMI 31·2 kg/m(2) [4·8]) were randomly assigned, 834 to IDegLira, 414 to insulin degludec, and 415 to liraglutide. After 26 weeks, mean HbA1c had decreased by 1·9% (SD 1·1) to 6·4% (1·0) with IDegLira, by 1·4% (1·0) to 6·9% (1·1) with insulin degludec, and by 1·3% (1·1) to 7·0% (1·2) with liraglutide. IDegLira was non-inferior to insulin degludec (estimated treatment difference -0·47%, 95% CI -0·58 to -0·36, p0·0001) and superior to liraglutide (-0·64%, -0·75 to -0·53, p0·0001). IDegLira was generally well tolerated; fewer participants in the IDegLira group than in the liraglutide group reported gastrointestinal adverse events (nausea 8·8 vs 19·7%), although the insulin degludec group had the fewest participants with gastrointestinal adverse events (nausea 3·6%). We noted no clinically relevant differences between treatments with respect to standard safety assessments, and the safety profile of IDegLira reflected those of its component parts. The number of confirmed hypoglycaemic events per patient year was 1·8 for IDegLira, 0·2 for liraglutide, and 2·6 for insulin degludec. Serious adverse events occurred in 19 (2%) of 825 patients in the IDegLira group, eight (2%) of 412 in the insulin degludec group, and 14 (3%) of 412 in the liraglutide group.IDegLira combines the clinical advantages of basal insulin and GLP-1 receptor agonist treatment, resulting in improved glycaemic control compared with its components given alone.Novo Nordisk.
Published: 2014

49. Notes on information-lossless finite-state automata

Author: Huffman, D. A.
Published: 1959
Full Text: View/download PDF

50. A linear circuit viewpoint on error-correcting codes

Author: Huffman, D. A.
Published: 1959
Full Text: View/download PDF

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