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93 results on '"Huerta, Jose M"'

2. Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study

Author

Murphy, Neil, Ward, Heather A., Jenab, Mazda, Rothwell, Joseph A., Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Kvaskoff, Marina, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Weiderpass, Elisabete, Skeie, Guri, Borch, Kristin Benjaminsen, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Dahm, Christina C., Jakszyn, Paula, Sánchez, Maria-Jose, Gil, Leire, Huerta, José M., Barricarte, Aurelio, Quirós, J. Ramón, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E., Trichopoulou, Antonia, La Vecchia, Carlo, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Fasanelli, Francesca, Panico, Salvatore, Bueno-de-Mesquita, Bas, Peeters, Petra H., Gylling, Björn, Myte, Robin, Jirström, Karin, Berntsson, Jonna, Xue, Xiaonan, Riboli, Elio, Cross, Amanda J., and Gunter, Marc J.

Published
2019
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3. Meat and haem iron intake in relation to glioma in the European Prospective Investigation into Cancer and Nutrition study

Author

Ward, Heather A., Gayle, Alicia, Jakszyn, Paula, Merritt, Melissa, Melin, Beatrice, Freisling, Heinz, Weiderpass, Elisabete, Tjonneland, Anne, Olsen, Anja, Dahm, Christina C., Overvad, Kim, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Kyrozis, Andreas, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Bueno-de-Mesquita, Bas, Peeters, Petra H., Quirós, José Ramón, Agudo, Antonio, Rodriguez-Barranco, Miguel, Larrañaga, Nerea, Huerta, José M., Barricarte, Aurelio, Sonestedt, Emily, Drake, Isabel, Sandström, Maria, Travis, Ruth C., Ferrari, Pietro, Riboli, Elio, and Cross, Amanda J.

Published
2018

4. Protein and amino acid intakes in relation to prostate cancer risk and mortality-A prospective study in the European Prospective Investigation into Cancer and Nutrition

Author

Schmidt, Julie A., Huybrechts, Inge, Overvad, Kim, Eriksen, Anne Kirstine, Tjonneland, Anne, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Pala, Valeria, Sacerdote, Carlotta, Tumino, Rosario, Bueno-de-Mesquita, Bas, Sanchez, Maria-Jose, Huerta, Jose M., Barricarte, Aurelio, Amiano, Pilar, Agudo, Antonio, Bjartell, Anders, Stocks, Tanja, Thysell, Elin, Wennberg, Maria, Weiderpass, Elisabete, Travis, Ruth C., Key, Timothy J., Perez-Cornago, Aurora, Schmidt, Julie A., Huybrechts, Inge, Overvad, Kim, Eriksen, Anne Kirstine, Tjonneland, Anne, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Pala, Valeria, Sacerdote, Carlotta, Tumino, Rosario, Bueno-de-Mesquita, Bas, Sanchez, Maria-Jose, Huerta, Jose M., Barricarte, Aurelio, Amiano, Pilar, Agudo, Antonio, Bjartell, Anders, Stocks, Tanja, Thysell, Elin, Wennberg, Maria, Weiderpass, Elisabete, Travis, Ruth C., Key, Timothy J., and Perez-Cornago, Aurora

Abstract

Background The association between protein intake and prostate cancer risk remains unclear. Aims To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. Methods In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid intakes were estimated using validated dietary questionnaires. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results During a mean follow-up of 14.2 years, 6939 men were diagnosed with prostate cancer and 914 died of the disease. Dairy protein was positively associated with overall prostate cancer risk in the three highest fifths compared to the lowest (HRQ3=1.14 (95% CI 1.05-1.23); HR(Q)4=1.09 (1.01-1.18); HRQ5=1.10 (1.02-1.19)); similar results were observed for yogurt protein (HRQ3=1.14 (1.05-1.24); HRQ4=1.09 (1.01-1.18); HRQ5=1.12 (1.04-1.21)). For egg protein intake and prostate cancer mortality, no association was observed by fifths, but there was suggestive evidence of a positive association in the analysis per standard deviation increment. There was no strong evidence of associations with different tumour subtypes. Discussion Considering the weak associations and many tests, the results must be interpreted with caution. Conclusion This study does not provide strong evidence for an association of intakes of total protein, protein from different dietary sources or amino acids with prostate cancer risk or mortality. However, our results may suggest some weak positive associations, which need to be confirmed in large-scale, pooled analyses of prospective data.

Published
2023

5. Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Author

Merritt, Melissa A, Tzoulaki, Ioanna, van den Brandt, Piet A, Schouten, Leo J, Tsilidis, Konstantinos K, Weiderpass, Elisabete, Patel, Chirag J, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, His, Mathilde, Dartois, Laureen, Boutron-Ruault, Marie-Christine, Fortner, Renée T, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Bueno-de-Mesquita, H Bas, Onland-Moret, N Charlotte, Peeters, Petra H, Skeie, Guri, Jareid, Mie, Quirós, J Ramón, Obón-Santacana, Mireia, Sánchez, María-José, Chamosa, Saioa, Huerta, José M, Barricarte, Aurelio, Dias, Joana A, Sonestedt, Emily, Idahl, Annika, Lundin, Eva, Wareham, Nicholas J, Khaw, Kay-Tee, Travis, Ruth C, Ferrari, Pietro, Riboli, Elio, and Gunter, Marc J

Published
2016
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7. Longitudinal changes in weight in relation to smoking cessation in participants of the EPIC-PANACEA study

Author

Travier, Noémie, Agudo, Antonio, May, Anne M., Gonzalez, Carlos, Luan, Jian'an, Wareham, Nick J., Bueno-de-Mesquita, H. Bas, van den Berg, Saskia W., Slimani, Nadia, Rinaldi, Sabina, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Palli, Domenico, Sieri, Sabina, Mattiello, Amalia, Tumino, Rosario, Vineis, Paolo, Norat, Teresa, Romaguera, Dora, Rodriguez, Laudina, Sanchez, Maria-José, Dorronsoro, Miren, Barricarte, Aurelio, Huerta, José M., Key, Tim J., Orfanos, Philippos, Naska, Androniki, Trichopoulou, Antonia, Rohrmann, Sabina, Kaaks, Rudolf, Bergmann, Manuela M., Boeing, Heiner, Hallmans, Goran, Johansson, Ingegerd, Manjer, Jonas, Lindkvist, Björn, Jakobsen, Mariane U., Overvad, Kim, Tjonneland, Anne, Halkjaer, Jytte, Lund, Eiliv, Braaten, Toni, Odysseos, Andreani, Riboli, Elio, and Peeters, Petra H.

Published
2012
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9. Attitudes of County Extension Agents toward Agent Specialization in Ohio.

Author

Huerta, Jose M. and Smith, Keith L.

Abstract

Most of the 285 Ohio extension agents (94% response) participating in agent specialization were moderately satisfied; they preferred to receive training through state/district conferences and formal classes. Greatest educational needs were balancing specialization with other program responsibilities and ensuring meaningful content. (SK)

Published
1994

13. Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European prospective investigation into cancer-eurgast cohort

Author

Companioni, Osmel, Bonet, Catalina, Muñoz, Xavier, Weiderpass, Elisabete, Panico, Salvatore, Tumino, Rosario, Palli, Domenico, Agnoli, Claudia, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Racine, Antoine, Clavel-Chapelon, Françoise, Travis, Ruth C., Khaw, Kay-Tee, Riboli, Elio, Murphy, Neil, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Benetou, Vassiliki, Trichopoulos, Dimitrios, Lund, Eiliv, Johansen, Dorthe, Lindkvist, Björn, Johansson, Mattias, Sund, Malin, Ardanaz, Eva, Sánchez-Cantalejo, Emilio, Huerta, Jose M., Dorronsoro, Miren, Quirós, José Ramón, Tjonneland, Anne, Mortensen, Lotte Maxild, Overvad, Kim, Chang-Claude, Jenny, Rizzato, Cosmeri, Boeing, Heiner, de Mesquita, Bas H. Bueno, Siersema, Peter, Peeters, Petra H.M., Numans, Mattijs E., Carneiro, Fatima, Licaj, Idlir, Freisling, Heinz, Sala, Núria, and González, Carlos A.

Published
2014
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14. A robust predictive current control for three-phase grid-connected inverters

Author

Moreno, Jaime Castello, Huerta, Jose M. Espi, Gil, Rafael Garcia, and Gonzalez, Sergio Alejandro

Subjects
Electric inverters -- Design and construction, Electric inverters -- Control, Algorithms -- Usage, Algorithm, Business, Computers, Electronics, Electronics and electrical industries
Abstract

This paper presents a new predictive control algorithm for grid-connected current-controlled inverters. The control combines a two-sample deadbeat control law with a Luenberger observer to estimate the future value of the grid currents. The resulting control offers robustness against the computational delay inherent in the digital implementation and considerably enhances the gain and phase margins of the previous predictive controls while maintaining the high-speed response typical of the deadbeat controllers. Index Terms--Current-controlled voltage-source inverter (CC-VSI), robust predictive current control (RPCC).

Published
2009

15. Consumption of ultra-processed foods and drinks and colorectal, breast, and prostate cancer

Author

Romaguera, Dora, primary, Fernández-Barrés, Sílvia, additional, Gracia-Lavedán, Esther, additional, Vendrell, Eva, additional, Azpiri, Mikel, additional, Ruiz-Moreno, Emma, additional, Martín, Vicente, additional, Gómez-Acebo, Inés, additional, Obón, Mireia, additional, Molinuevo, Amaia, additional, Fresán, Ujué, additional, Molina-Barceló, Ana, additional, Olmedo-Requena, Rocío, additional, Tardón, Adonina, additional, Alguacil, Juan, additional, Solans, Marta, additional, Huerta, Jose M., additional, Ruiz-Dominguez, José Manuel, additional, Aragonés, Nuria, additional, Fernández-Villa, Tania, additional, Dierssen-Sotos, Trinidad, additional, Moreno, Victor, additional, Guevara, Marcela, additional, Vanaclocha-Espi, Mercedes, additional, Lozano-Lorca, Macarena, additional, Fernández-Tardón, Guillermo, additional, Castaño-Vinyals, Gemma, additional, Pérez-Gómez, Beatriz, additional, Molina, Antonio J., additional, Llorca, Javier, additional, Gil, Leire, additional, Castilla, Jesús, additional, Pollán, Marina, additional, Kogevinas, Manolis, additional, and Amiano, Pilar, additional

Published
2021
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16. Design of the L-LC resonant inverter for induction heating based on its equivalent SRI

Author

Huerta, Jose M. Espi, Santamaria, Enrique J. Dede Garcia, Gil, Rafael Garcia, and Moreno, Jaime Castello

Subjects
Electric inverters -- Design and construction, Induction heating -- Equipment and supplies, Circuit design -- Evaluation, Circuit designer, Integrated circuit design, Business, Computers, Electronics, Electronics and electrical industries
Abstract

This paper presents the new L-LC induction heating generator and probes that, in resonance, are equivalent to a series resonant inverter. This equivalence is then used to compare both topologies, extracting the advantages and disadvantages of the L-LC usage. In addition, based on this equivalence, a design procedure is proposed that covers all possible L-LC configurations. Finally, some experimental results are presented, showing waveforms during normal and short-circuit operation. Index Terms--Active transformer, hybrid series--parallel resonant inverter (L-LC), parallel resonant inverter (PRI), reactive transformer, series resonant inverter (SRI).

Published
2007

17. Healthy lifestyle and the risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition study

Author

Naudin, Sabine, Margalef, Marta Solans, Hosnijeh, Fatemeh Saberi, Nieters, Alexandra, Kyrø, Cecilie, Tjonneland, Anne, Dahm, Christina C., Overvad, Kim, Mahamat-Saleh, Yahya, Besson, Caroline, Boutron-Ruault, Marie-Christine, Kuehn, Tilman, Canzian, Federico, Schulze, Matthias B., Peppa, Eleni, Karakatsani, Anna, Trichopoulou, Antonia, Sieri, Sabina, Masala, Giovana, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Chen, Sairah L. F., Barroso, Leila L., Huerta, Jose M., Sanchez, Maria-Jose, Ardanaz, Eva, Menendez, Virginia, Exezarreta, Pilar Amiano, Spaeth, Florentin, Jerkeman, Mats, Jirstom, Karin, Schmidt, Julie A., Aune, Dagfinn, Weiderpass, Elisabete, Riboli, Elio, Vermeulen, Roel, Casabonne, Delphine, Gunter, Marc, Brennan, Paul, Ferrari, Pietro, Naudin, Sabine, Margalef, Marta Solans, Hosnijeh, Fatemeh Saberi, Nieters, Alexandra, Kyrø, Cecilie, Tjonneland, Anne, Dahm, Christina C., Overvad, Kim, Mahamat-Saleh, Yahya, Besson, Caroline, Boutron-Ruault, Marie-Christine, Kuehn, Tilman, Canzian, Federico, Schulze, Matthias B., Peppa, Eleni, Karakatsani, Anna, Trichopoulou, Antonia, Sieri, Sabina, Masala, Giovana, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Chen, Sairah L. F., Barroso, Leila L., Huerta, Jose M., Sanchez, Maria-Jose, Ardanaz, Eva, Menendez, Virginia, Exezarreta, Pilar Amiano, Spaeth, Florentin, Jerkeman, Mats, Jirstom, Karin, Schmidt, Julie A., Aune, Dagfinn, Weiderpass, Elisabete, Riboli, Elio, Vermeulen, Roel, Casabonne, Delphine, Gunter, Marc, Brennan, Paul, and Ferrari, Pietro

Published
2020

18. Serum selenium is associated with plasma homocysteine concentrations in elderly humans

Author

Gonzalez, Sonia, Huerta, Jose M., Alvarez-Uria, Julieta, Fernandez, Serafina, Patterson, Angeles M., and Lasheras, Christina

Subjects
Cardiovascular diseases -- Causes of, Homocysteine -- Research, Food/cooking/nutrition
Abstract

Low selenium levels in humans have been associated with several pathologies; however, an earlier animal investigation found a direct association between Se intake and total plasma homocysteine (tHcy) concentrations. To date, the importance of serum selenium levels in association with tHcy in humans has not been determined. We evaluated the cross-sectional association of blood selenium concentrations with plasma tHcy and other determinants of this cardiovascular disease risk factor. We estimated protein intake and measured the blood status of selenium, tHcy, and several other related factors in serum such as folate, vitamin B-12, and creatinine. Serum selenium was inversely associated with tHcy, explaining 5.8% of tHcy variance with respect to 2.2% accounted for by serum folate. Furthermore, there was a 63% decreased risk of higher tHcy concentrations (>14 [micro]mol/L) for subjects with serum selenium in the highest tertile (P = 0.013). We also found an inverse association of protein intake with tHcy in men ([beta] = -0.144; P = 0.036), which disappeared after controlling for serum Se concentrations ([beta] = -0.055; P = 0.003). In conclusion, selenium should be considered as a potential factor to lower tHcy. In addition, the described association between protein intake and homocysteine levels could be mediated by this trace element. KEY WORDS: * homocysteine * selenium * folate * cardiovascular disease * trace elements

Published
2004

19. Food habits are associated with lipid peroxidation in an elderly population

Author

Lasheras, Cristina, Gonzalez, Sonia, Huerta, Jose M., Lombardia, Clara, Ibanez, Raquel, Patterson, Angeles M., and Fernandez, Serafina

Subjects
Food habits -- Research, Aged -- Food and nutrition, Lipid peroxidation
Abstract

Objective The purpose of this study was to assess the association between dietary intake and lipid peroxidation. Design Cross-sectional population analysis from an ongoing prospective study. Malondialdehyde (MDA) was measured as a marker of lipid peroxidation. Diet was assessed through direct observation and food frequency questionnaire. Subjects Participants with no missing data were 162 nonsmoking elderly individuals residing in 7 institutions across Asturias (Spain). Statistical analyses performed Comparisons of adjusted group means by tertiles of plasma MDA were made by analysis of variance. Stepwise regression analysis was done using MDA as a dependent variable and food intake as an independent variable. Food intakes were categorized into quartiles and logistic regression was applied to calculate the odds ratio for being in the highest tertile of plasma MDA. Results Consumption of potatoes had an independent direct effect and accounted for a sizeable proportion of the variation in plasma MDA levels 08%, P<.001). In addition to potatoes, other foods that had an apparently independent effect on plasma MDA were eggs, cooked vegetables, and red wine ([R.sup.2]=0.028, 0.023 and 0.018, respectively). In this study, dietary factors accounted for 25% of the variation in plasma MDA levels. Conclusion Identifying nutritional determinants of oxidative stress is important because of its negative health effect. Consumption of cooked vegetables and moderate intake of wine has been shown to be appropriate for reducing the risk of oxidative damage. On the contrary, caution must be used with the intake of potatoes because we have found a positive association with MDA levels. Further studies are required to investigate the mechanism(s) of this association and whether it is related to the preparation method or to the potato itself.

Published
2003

20. Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

Author

Jakszyn, Paula, primary, Cayssials, Valerie, additional, Buckland, Genevieve, additional, Perez‐Cornago, Aurora, additional, Weiderpass, Elisabete, additional, Boeing, Heiner, additional, Bergmann, Manuela M., additional, Vulcan, Alexandra, additional, Ohlsson, Bodil, additional, Masala, Giovanna, additional, Cross, Amanda J., additional, Riboli, Elio, additional, Ricceri, Fulvio, additional, Dahm, Christina C., additional, Nyvang, Dorthe, additional, Katzke, Verena A., additional, Kühn, Tilman, additional, Kyrø, Cecilie, additional, Tjønneland, Anne, additional, Ward, Heather A., additional, Tsilidis, Konstantinos K., additional, Skeie, Guri, additional, Sieri, Sabina, additional, Sanchez, Maria‐Jose, additional, Huerta, Jose M., additional, Amiano, Pilar, additional, Lasheras, Cristina, additional, Ardanaz, Eva, additional, Mahamat‐Saleh, Yahya, additional, Boutron‐Ruault, Marie‐Christine, additional, Carbonnel, Franck, additional, Panico, Salvatore, additional, Peppa, Eleni, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Tumino, Rosario, additional, Vermeulen, Roel, additional, Jenab, Mazda, additional, Gunter, Marc, additional, and Agudo, Antonio, additional

Published
2020
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23. Meat and haem iron intake in relation to glioma in the European Prospective Investigation into Cancer and Nutrition study

Author

Ward, Heather A. Gayle, Alicia Jakszyn, Paula Merritt, Melissa Melin, Beatrice Freisling, Heinz Weiderpass, Elisabete Tjonneland, Anne Olsen, Anja Dahm, Christina C. and Overvad, Kim Katzke, Verena Kuehn, Tilman Boeing, Heiner and Trichopoulou, Antonia Lagiou, Pagona Kyrozis, Andreas and Palli, Domenico Krogh, Vittorio Tumino, Rosario Ricceri, Fulvio Mattiello, Amalia Bueno-de-Mesquita, Bas Peeters, Petra H. Quiros, Jose Ramon Agudo, Antonio and Rodriguez-Barranco, Miguel Larranaga, Nerea Huerta, Jose M. and Barricarte, Aurelio Sonestedt, Emily Drake, Isabel and Sandstroem, Maria Travis, Ruth C. Ferrari, Pietro Riboli, Elio Cross, Amanda J.

Subjects
food and beverages
Abstract

Diets high in red or processed meat have been associated positively with some cancers, and several possible underlying mechanisms have been proposed, including iron-related pathways. However, the role of meat intake in adult glioma risk has yielded conflicting findings because of small sample sizes and heterogeneous tumour classifications. The aim of this study was to examine red meat, processed meat and iron intake in relation to glioma risk in the European Prospective Investigation into Cancer and Nutrition study. In this prospective cohort study, 408751 individuals from nine European countries completed demographic and dietary questionnaires at recruitment. Multivariable Cox proportional hazards models were used to examine intake of red meat, processed meat, total dietary iron and haem iron in relation to incident glioma. During an average follow-up of 14.1 years, 688 incident glioma cases were diagnosed. There was no evidence that any of the meat variables (red, processed meat or subtypes of meat) or iron (total or haem) were associated with glioma; results were unchanged when the first 2 years of follow-up were excluded. This study suggests that there is no association between meat or iron intake and adult glioma. This is the largest prospective analysis of meat and iron in relation to glioma and as such provides a substantial contribution to a limited and inconsistent literature.

Published
2018

24. Risk thresholds for alcohol consumption : combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

Author

Wood, Angela M., Kaptoge, Stephen, Butterworth, Adam S., Willeit, Peter, Warnakula, Samantha, Bolton, Thomas, Paige, Ellie, Paul, Dirk S., Sweeting, Michael, Burgess, Stephen, Bell, Steven, Astle, William, Stevens, David, Koulman, Albert, Selmer, Randi M., Verschuren, W. M. Monique, Sato, Shinichi, Njolstad, Inger, Woodward, Mark, Salomaa, Veikko, Nordestgaard, Borge G., Yeap, Bu B., Fletcher, Astrid, Melander, Olle, Kuller, Lewis H., Balkau, Beverley, Marmot, Michael, Koenig, Wolfgang, Casiglia, Edoardo, Cooper, Cyrus, Arndt, Volker, Franco, Oscar H., Wennberg, Patrik, Gallacher, John, de la Camara, Agustin Gomez, Volzke, Henry, Dahm, Christina C., Dale, Caroline E., Bergmann, Manuela M., Crespo, Carlos J., van der Schouw, Yvonne T., Kaaks, Rudolf, Simons, Leon A., Lagiou, Pagona, Schoufour, Josje D., Boer, Jolanda M. A., Key, Timothy J., Rodriguez, Beatriz, Moreno-Iribas, Conchi, Davidson, Karina W., Taylor, James O., Sacerdote, Carlotta, Wallace, Robert B., Quiros, J. Ramon, Tumino, Rosario, Blazer, Dan G., II, Linneberg, Allan, Daimon, Makoto, Panico, Salvatore, Howard, Barbara, Skeie, Guri, Strandberg, Timo, Weiderpass, Elisabete, Nietert, Paul J., Psaty, Bruce M., Kromhout, Daan, Salamanca-Fernandez, Elena, Kiechl, Stefan, Krumholz, Harlan M., Grioni, Sara, Palli, Domenico, Huerta, Jose M., Price, Jackie, Sundström, Johan, Arriola, Larraitz, Arima, Hisatomi, Travis, Ruth C., Panagiotakos, Demosthenes B., Karakatsani, Anna, Trichopoulou, Antonia, Kuhn, Tilman, Grobbee, Diederick E., Barrett-Connor, Elizabeth, van Schoor, Natasja, Boeing, Heiner, Overvad, Kim, Kauhanen, Jussi, Wareham, Nick, Langenberg, Claudia, Forouhi, Nita, Wennberg, Maria, Despres, Jean-Pierre, Cushman, Mary, Cooper, Jackie A., Rodriguez, Carlos J., Sakurai, Masaru, Shaw, Jonathan E., Knuiman, Matthew, Voortman, Trudy, Meisinger, Christa, Tjonneland, Anne, Brenner, Hermann, Palmieri, Luigi, Dallongeville, Jean, Brunner, Eric J., Assmann, Gerd, Trevisan, Maurizio, Gillum, Richard F., Ford, Ian, Sattar, Naveed, Lazo, Mariana, Thompson, Simon G., Ferrari, Pietro, Leon, David A., Smith, George Davey, Peto, Richard, Jackson, Rod, Banks, Emily, Di Angelantonio, Emanuele, Danesh, John, Wood, Angela M., Kaptoge, Stephen, Butterworth, Adam S., Willeit, Peter, Warnakula, Samantha, Bolton, Thomas, Paige, Ellie, Paul, Dirk S., Sweeting, Michael, Burgess, Stephen, Bell, Steven, Astle, William, Stevens, David, Koulman, Albert, Selmer, Randi M., Verschuren, W. M. Monique, Sato, Shinichi, Njolstad, Inger, Woodward, Mark, Salomaa, Veikko, Nordestgaard, Borge G., Yeap, Bu B., Fletcher, Astrid, Melander, Olle, Kuller, Lewis H., Balkau, Beverley, Marmot, Michael, Koenig, Wolfgang, Casiglia, Edoardo, Cooper, Cyrus, Arndt, Volker, Franco, Oscar H., Wennberg, Patrik, Gallacher, John, de la Camara, Agustin Gomez, Volzke, Henry, Dahm, Christina C., Dale, Caroline E., Bergmann, Manuela M., Crespo, Carlos J., van der Schouw, Yvonne T., Kaaks, Rudolf, Simons, Leon A., Lagiou, Pagona, Schoufour, Josje D., Boer, Jolanda M. A., Key, Timothy J., Rodriguez, Beatriz, Moreno-Iribas, Conchi, Davidson, Karina W., Taylor, James O., Sacerdote, Carlotta, Wallace, Robert B., Quiros, J. Ramon, Tumino, Rosario, Blazer, Dan G., II, Linneberg, Allan, Daimon, Makoto, Panico, Salvatore, Howard, Barbara, Skeie, Guri, Strandberg, Timo, Weiderpass, Elisabete, Nietert, Paul J., Psaty, Bruce M., Kromhout, Daan, Salamanca-Fernandez, Elena, Kiechl, Stefan, Krumholz, Harlan M., Grioni, Sara, Palli, Domenico, Huerta, Jose M., Price, Jackie, Sundström, Johan, Arriola, Larraitz, Arima, Hisatomi, Travis, Ruth C., Panagiotakos, Demosthenes B., Karakatsani, Anna, Trichopoulou, Antonia, Kuhn, Tilman, Grobbee, Diederick E., Barrett-Connor, Elizabeth, van Schoor, Natasja, Boeing, Heiner, Overvad, Kim, Kauhanen, Jussi, Wareham, Nick, Langenberg, Claudia, Forouhi, Nita, Wennberg, Maria, Despres, Jean-Pierre, Cushman, Mary, Cooper, Jackie A., Rodriguez, Carlos J., Sakurai, Masaru, Shaw, Jonathan E., Knuiman, Matthew, Voortman, Trudy, Meisinger, Christa, Tjonneland, Anne, Brenner, Hermann, Palmieri, Luigi, Dallongeville, Jean, Brunner, Eric J., Assmann, Gerd, Trevisan, Maurizio, Gillum, Richard F., Ford, Ian, Sattar, Naveed, Lazo, Mariana, Thompson, Simon G., Ferrari, Pietro, Leon, David A., Smith, George Davey, Peto, Richard, Jackson, Rod, Banks, Emily, Di Angelantonio, Emanuele, and Danesh, John

Abstract

Background: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. Methods: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank). We characterised dose-response associations and calculated hazard ratios (HRs) per 100 g per week of alcohol (12.5 units per week) across 83 prospective studies, adjusting at least for study or centre, age, sex, smoking, and diabetes. To be eligible for the analysis, participants had to have information recorded about their alcohol consumption amount and status (ie, non-drinker vs current drinker), plus age, sex, history of diabetes and smoking status, at least 1 year of follow-up after baseline, and no baseline history of cardiovascular disease. The main analyses focused on current drinkers, whose baseline alcohol consumption was categorised into eight predefined groups according to the amount in grams consumed per week. We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtypes. We corrected HRs for estimated long-term variability in alcohol consumption using 152 640 serial alcohol assessments obtained some years apart (median interval 5.6 years [5th-95th percentile 1.04-13.5]) from 71 011 participants from 37 studies. Findings: In the 599 912 current drinkers included in the analysis, we recorded 40 310 deaths and 39 018 incident cardiovascular disease events during 5.4 million person-years of follow-up. For all-cause mortality, we recorded a positive and curvilinear association with the level of alcohol consumption, with the minimum mortality risk around

Published
2018
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25. Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins

Author

Guida, Florence, Sun, Nan, Bantis, Leonidas E., Muller, David C., Li, Peng, Taguchi, Ayumu, Dhillon, Dilsher, Kundnani, Deepali L., Patel, Nikul J., Yan, Qingxiang, Byrnes, Graham, Moons, Karel G. M., Tjonneland, Anne, Panico, Salvatore, Agnoli, Claudia, Vineis, Paolo, Palli, Domenico, Bueno-de-Mesquita, Bas, Peeters, Petra H., Agudo, Antonio, Huerta, Jose M., Dorronsoro, Miren, Rodriguez Barranco, Miguel, Ardanaz, Eva, Travis, Ruth C., Byme, Karl Smith, Boeing, Heiner, Steffen, Annika, Kaaks, Rudolf, Huesing, Anika, Trichopoulou, Antonia, Lagiou, Pagona, La Vecchia, Carlo, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Sandanger, Torkjel M., Weiderpass, Elisabete, Nost, Therese H., Tsilidis, Kostas, Riboli, Elio, Grankvist, Kjell, Johansson, Mikael, Goodman, Gary E., Feng, Ziding, Brennan, Paul, Johansson, Mattias, Hanash, Samir M., Guida, Florence, Sun, Nan, Bantis, Leonidas E., Muller, David C., Li, Peng, Taguchi, Ayumu, Dhillon, Dilsher, Kundnani, Deepali L., Patel, Nikul J., Yan, Qingxiang, Byrnes, Graham, Moons, Karel G. M., Tjonneland, Anne, Panico, Salvatore, Agnoli, Claudia, Vineis, Paolo, Palli, Domenico, Bueno-de-Mesquita, Bas, Peeters, Petra H., Agudo, Antonio, Huerta, Jose M., Dorronsoro, Miren, Rodriguez Barranco, Miguel, Ardanaz, Eva, Travis, Ruth C., Byme, Karl Smith, Boeing, Heiner, Steffen, Annika, Kaaks, Rudolf, Huesing, Anika, Trichopoulou, Antonia, Lagiou, Pagona, La Vecchia, Carlo, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Sandanger, Torkjel M., Weiderpass, Elisabete, Nost, Therese H., Tsilidis, Kostas, Riboli, Elio, Grankvist, Kjell, Johansson, Mikael, Goodman, Gary E., Feng, Ziding, Brennan, Paul, Johansson, Mattias, and Hanash, Samir M.

Abstract

Importance There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of cases. Objective To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction model and current US screening criteria. Design, Setting, and Participants Prediagnostic samples from 108 ever-smoking patients with lung cancer diagnosed within 1 year after blood collection and samples from 216 smoking-matched controls from the Carotene and Retinol Efficacy Trial (CARET) cohort were used to develop a biomarker risk score based on 4 proteins (cancer antigen 125 [CA125], carcinoembryonic antigen [CEA], cytokeratin-19 fragment [CYFRA 21-1], and the precursor form of surfactant protein B [Pro-SFTPB]). The biomarker score was subsequently validated blindly using absolute risk estimates among 63 ever-smoking patients with lung cancer diagnosed within 1 year after blood collection and 90 matched controls from 2 large European population-based cohorts, the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Northern Sweden Health and Disease Study (NSHDS). Main Outcomes and Measures Model validity in discriminating between future lung cancer cases and controls. Discrimination estimates were weighted to reflect the background populations of EPIC and NSHDS validation studies (area under the receiver-operating characteristics curve [AUC], sensitivity, and specificity). Results In the validation study of 63 ever-smoking patients with lung cancer and 90 matched controls (mean [SD] age, 57.7 [8.7] years; 68.6% men) from EPIC and NSHDS, an integrated risk prediction model that combined smoking exposure with the biomarker score yielded an AUC of 0.83 (95% CI, 0.76-0.90) compared with 0.73 (95% CI, 0.64-0.82) for a model based on smoking exposure alone (P = .003 for difference in AUC). At an overall specificity of 0.83, base, En rättelse har publicerats. DOI: 10.1001/jamaoncol.2018.4576.A correction has been published. DOI: 10.1001/jamaoncol.2018.4576.

Published
2018
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26. Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins

Author

Epi Methoden, Child Health, Cancer, Circulatory Health, JC onderzoeksprogramma Methodologie, MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Guida, Florence, Sun, Nan, Bantis, Leonidas E, Muller, David C, Li, Peng, Taguchi, Ayumu, Dhillon, Dilsher, Kundnani, Deepali L, Patel, Nikul J, Yan, Qingxiang, Byrnes, Graham, Moons, Karel G M, Tjønneland, Anne, Panico, Salvatore, Agnoli, Claudia, Vineis, Paolo, Palli, Domenico, Bueno-de-Mesquita, Bas, Peeters, Petra H, Agudo, Antonio, Huerta, Jose M, Dorronsoro, Miren, Barranco, Miguel Rodriguez, Ardanaz, Eva, Travis, Ruth C, Byrne, Karl Smith, Boeing, Heiner, Steffen, Annika, Kaaks, Rudolf, Hüsing, Anika, Trichopoulou, Antonia, Lagiou, Pagona, La Vecchia, Carlo, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Sandanger, Torkjel M, Weiderpass, Elisabete, Nøst, Therese H, Tsilidis, Kostas, Riboli, Elio, Grankvist, Kjell, Johansson, Mikael, Goodman, Gary E, Feng, Ziding, Brennan, Paul, Johansson, Mattias, Hanash, Samir M, Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer, Epi Methoden, Child Health, Cancer, Circulatory Health, JC onderzoeksprogramma Methodologie, MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Guida, Florence, Sun, Nan, Bantis, Leonidas E, Muller, David C, Li, Peng, Taguchi, Ayumu, Dhillon, Dilsher, Kundnani, Deepali L, Patel, Nikul J, Yan, Qingxiang, Byrnes, Graham, Moons, Karel G M, Tjønneland, Anne, Panico, Salvatore, Agnoli, Claudia, Vineis, Paolo, Palli, Domenico, Bueno-de-Mesquita, Bas, Peeters, Petra H, Agudo, Antonio, Huerta, Jose M, Dorronsoro, Miren, Barranco, Miguel Rodriguez, Ardanaz, Eva, Travis, Ruth C, Byrne, Karl Smith, Boeing, Heiner, Steffen, Annika, Kaaks, Rudolf, Hüsing, Anika, Trichopoulou, Antonia, Lagiou, Pagona, La Vecchia, Carlo, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Sandanger, Torkjel M, Weiderpass, Elisabete, Nøst, Therese H, Tsilidis, Kostas, Riboli, Elio, Grankvist, Kjell, Johansson, Mikael, Goodman, Gary E, Feng, Ziding, Brennan, Paul, Johansson, Mattias, Hanash, Samir M, and Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer

Published
2018

27. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author

Freisling, Heinz Pisa, Pedro T. Ferrari, Pietro Byrnes, Graham Moskal, Aurelie Dahm, Christina C. Vergnaud, Anne-Claire Boutron-Ruault, Marie-Christine Fagherazzi, Guy and Cadeau, Claire Kuehn, Tilman Neamat-Allah, Jasmine Buijsse, Brian Boeing, Heiner Halkjaer, Jytte Tjonneland, Anne and Hansen, Camilla P. Ramon Quiros, J. Travier, Noemie and Molina-Montes, Esther Amiano, Pilar Huerta, Jose M. and Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nicholas Key, Tim J. Romaguera, Dora Lu, Yunxia Lassale, Camille M. Naska, Androniki Orfanos, Philippos Trichopoulou, Antonia Masala, Giovanna Pala, Valeria Berrino, Franco Tumino, Rosario and Ricceri, Fulvio de Magistris, Maria Santucci Bueno-de-Mesquita, H. Bas Ocke, Marga C. Sonestedt, Emily Ericson, Ulrika and Johansson, Mattias Skeie, Guri Weiderpass, Elisabete and Braaten, Tonje Peeters, Petra H. M. Slimani, Nadia

Abstract

Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults. This study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders. Mean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant. We identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.

Published
2016

28. Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Author

Merritt, Melissa A. Tzoulaki, Joanna van den Brandt, Piet A. and Schouten, Leo J. Tsilidis, Konstantinos K. Weiderpass, Elisabete and Patel, Chirag J. Tjonneland, Anne Hansen, Louise and Overvad, Kim His, Mathilde Dartois, Laureen Boutron-Ruault, Marie-Christine Fortner, Renee T. Kaaks, Rudolf and Aleksandrova, Krasimira Boeing, Heiner Trichopoulou, Antonia and Lagiou, Pagona Bamia, Christina Palli, Domenico Krogh, Vittorio Tumino, Rosario Ricceri, Fulvio Mattiello, Amalia and Bueno-de-Mesquita, H. Bas Onland-Moret, N. Charlotte and Peeters, Petra H. Skeie, Guri Jareid, Mie Quiros, J. Ramon and Obon-Santacana, Mireia Sanchez, Maria-Jose Chamosa, Saioa and Huerta, Jose M. Barricarte, Aurelio Dias, Joana A. and Sonestedt, Emily Idahl, Annika Lundin, Eva Wareham, Nicholas J. Khaw, Kay-Tee Travis, Ruth C. Ferrari, Pietro Riboli, Elio Gunter, Marc J.

Subjects
endocrine system diseases, female genital diseases and pregnancy complications
Abstract

Background: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk. Objective: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort. Design: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs. Results: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall BR: 1.21; 95% CI: 1.04, 1.41). Conclusion: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.

Published
2016

29. Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Author

Merritt, Melissa A., Tzoulaki, Joanna, van den Brandt, Piet A., Schouten, Leo J., Tsilidis, Konstantinos K., Weiderpass, Elisabete, Patel, Chirag J., Tjonneland, Anne, Hansen, Louise, Overvad, Kim, His, Mathilde, Dartois, Laureen, Boutron-Ruault, Marie-Christine, Fortner, Renee T., Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Bueno-de-Mesquita, H. Bas, Onland-Moret, N. Charlotte, Peeters, Petra H., Skeie, Guri, Jareid, Mie, Quiros, J. Ramon, Obon-Santacana, Mireia, Sanchez, Maria-Jose, Chamosa, Saioa, Huerta, Jose M., Barricarte, Aurelio, Dias, Joana A., Sonestedt, Emily, Idahl, Annika, Lundin, Eva, Wareham, Nicholas J., Khaw, Kay-Tee, Travis, Ruth C., Ferrari, Pietro, Riboli, Elio, Gunter, Marc J., Merritt, Melissa A., Tzoulaki, Joanna, van den Brandt, Piet A., Schouten, Leo J., Tsilidis, Konstantinos K., Weiderpass, Elisabete, Patel, Chirag J., Tjonneland, Anne, Hansen, Louise, Overvad, Kim, His, Mathilde, Dartois, Laureen, Boutron-Ruault, Marie-Christine, Fortner, Renee T., Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Bueno-de-Mesquita, H. Bas, Onland-Moret, N. Charlotte, Peeters, Petra H., Skeie, Guri, Jareid, Mie, Quiros, J. Ramon, Obon-Santacana, Mireia, Sanchez, Maria-Jose, Chamosa, Saioa, Huerta, Jose M., Barricarte, Aurelio, Dias, Joana A., Sonestedt, Emily, Idahl, Annika, Lundin, Eva, Wareham, Nicholas J., Khaw, Kay-Tee, Travis, Ruth C., Ferrari, Pietro, Riboli, Elio, and Gunter, Marc J.

Abstract

Background: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk. Objective: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort. Design: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs. Results: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41). Conclusion: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.

Published
2016
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30. Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European Prospective Investigation into Cancer-Eurgast cohort

Author

Companioni, Osmel Bonet, Catalina Munoz, Xavier Weiderpass, Elisabete Panico, Salvatore Tumino, Rosario Palli, Domenico and Agnoli, Claudia Vineis, Paolo Boutron-Ruault, Marie-Christine Racine, Antoine Clavel-Chapelon, Francoise and Travis, Ruth C. Khaw, Kay-Tee Riboli, Elio Murphy, Neil and Vergnaud, Anne-Claire Trichopoulou, Antonia Benetou, Vassiliki and Trichopoulos, Dimitrios Lund, Eiliv Johansen, Dorthe and Lindkvist, Bjoern Johansson, Mattias Sund, Malin Ardanaz, Eva Sanchez-Cantalejo, Emilio Huerta, Jose M. Dorronsoro, Miren Ramon Quiros, Jose Tjonneland, Anne Mortensen, Lotte Maxild Overvad, Kim Chang-Claude, Jenny Rizzato, Cosmeri and Boeing, Heiner De Mesquita, H. Bas Bueno Siersema, Peter and Peeters, Petra H. M. Numans, Mattijs E. Carneiro, Fatima and Licaj, Idlir Freisling, Heinz Sala, Nuria Gonzalez, Carlos A.

Subjects
digestive system diseases
Abstract

Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. Single nucleotide polymorphisms (SNPs) in these genes have been associated with GC in different populations. We genotyped 30 SNPs of these genes, in 365 gastric adenocarcinomas and 1,284 matched controls from the European Prospective Investigation into Cancer cohort. The association with GC and its histological and anatomical subtypes was analyzed by logistic regression and corrected for multiple comparisons. Using a log-additive model, we found a significant association between SNPs in CD14, NOD2 and TLR4 with GC risk. However, after applying the multiple comparisons tests only the NOD2 region remained significant (p=0.009). Analysis according to anatomical subtypes revealed NOD2 and NFKB1 SNPs associated with noncardia GC and CD14 SNPs associated with cardia GC, while analysis according to histological subtypes showed that CD14 was associated with intestinal but not diffuse GC. The multiple comparisons tests confirmed the association of NOD2 with noncardia GC (p=0.0003) and CD14 with cardia GC (p=0.01). Haplotype analysis was in agreement with single SNP results for NOD2 and CD14 genes. From these results, we conclude that genetic variation in NOD2 associates with noncardia GC while variation in CD14 is associated with cardia GC. What’s new? Variations in immune genes appear to play an important role in determining susceptibility to gastric cancer linked to Helicobacter pylori colonization of gastric mucosa. However, little is known about the influence of variation on anatomical localization and histological subtype of this malignancy. The results of this study first confirm that NOD2 and CD14, which encode proteins that recognize H. pylori lipopolysaccharide and peptidoglycan, are significantly associated with gastric cancer risk and second indicate that NOD2 associates with noncardia and CD14 with cardia gastric cancer. The differential effects of variation on the anatomical localization of disease warrant further investigation.

Published
2014

31. Consumption of predefined 'Nordic' dietary items in ten European countries - an investigation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Roswall, Nina Olsen, Anja Boll, Katja Christensen, Jane and Halkjaer, Jytte Sorensen, Thorkild I. A. Dahm, Christina C. and Overvad, Kim Clavel-Chapelon, Franc Oise Boutron-Ruault, Marie C. Cottet, Vanessa Teucher, Birgit Kaaks, Rudolf Boeing, Heiner von Ruesten, Anne Trichopoulou, Antonia Oikonomou, Eleni Vasilopoulou, Effie Pala, Valeria Sacerdote, Carlotta and Mattiello, Amalia Masala, Giovanna Peeters, Petra H. M. and Bueno-de-Mesquita, H. Bas Engeset, Dagrun Skeie, Guri Asli, Lene A. Amiano, Pilar Jakszyn, Paula Ardanaz, Eva and Huerta, Jose M. Quiros, Jose R. Molina-Montes, Esther and Nilsson, Lena M. Johansson, Ingegerd Wirfalt, Elisabet and Drake, Isabel Mulligan, Angela A. Khaw, Kay T. Romaguera, Dora Vergnaud, Anne-Claire Key, Tim Riboli, Elio and Tjonneland, Anne

Abstract

Objective: Health-beneficial effects of adhering to a healthy Nordic diet index have been suggested. However, it has not been examined to what extent the included dietary components are exclusively related to the Nordic countries or if they are part of other European diets as well, suggesting a broader preventive potential. The present study describes the intake of seven a priori defined healthy food items (apples/pears, berries, cabbages, dark bread, shellfish, fish and root vegetables) across ten countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) and examines their consumption across Europe. Design: Cross-sectional study. A 24 h dietary recall was administered through a software program containing country-specific recipes. Sex-specific mean food intake was calculated for each centre/country, as well as percentage of overall food groups consumed as healthy Nordic food items. All analyses were weighted by day and season of data collection. Setting: Multi-centre, European study. Subjects: Persons (n 36 970) aged 35-74 years, constituting a random sample of 519 978 EPIC participants. Results: The highest intakes of the included diet components were: cabbages and berries in Central Europe; apples/pears in Southern Europe; dark bread in Norway, Denmark and Greece; fish in Southern and Northern countries; shellfish in Spain; and root vegetables in Northern and Central Europe. Large inter-centre variation, however, existed in some countries. Conclusions: Dark bread, root vegetables and fish are strongly related to a Nordic dietary tradition. Apples/pears, berries, cabbages, fish, shellfish and root vegetables are broadly consumed in Europe, and may thus be included in regional public health campaigns.

Published
2014

32. Meat and heme iron intake and esophageal adenocarcinoma the European Prospective investigation into Cancer and Nutrition study

Author

Jakszyn, Paula, Luján-Barroso, Leila, Agudo, Antonio, Bueno-de-Mesquita, H Bas, Molina, Esther, Sánchez, M José, Fonseca-Nunes, Ana, Siersema, Peter D, Matiello, Amalia, Tumino, Rosario, Saieva, Calogero, Pala, Valeria, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadie, Travis, Ruth C, Khaw, Kay-Tee, Riboli, Elio, Murphy, Neil, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Valanou, Elissavet, Oikonomidou, Despina, Weiderpass, Elisabete, Skeie, Guri, Johansen, Dorthe, Lindkvist, Björn, Johansson, Mattias, Duarte-Salles, Talita, Freisling, Heinz, Barricarte, Aurelio, Huerta, Jose M, Amiano, Pilar, Tjonneland, Anne, Overvad, Kim, Kuehn, Tilman, Grote, Verena, Boeing, Heiner, Peeters, Petra Hm, and González, Carlos A

Subjects
food and beverages
Abstract

Although recent studies suggest that high intakes of meat and heme iron are risk factors for several types of cancer, studies in relation to esophageal adenocarcinoma (EAC) are scarce. Previous results in the European Prospective Investigation into Cancer and Nutrition (EPIC) based on a relatively small number of cases suggested a positive association between processed meat and EAC. In this study we investigate the association between intake of different types of meats as well as heme iron intake, and EAC risk in a larger number of cases from EPIC. The study included 481,419 individuals and 137 incident cases of EAC that occurred during an average of 11 years of follow-up. Dietary intake of meat (unprocessed/processed red and white meat) was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat. After adjusting for relevant confounders we observed a statistically significant positive association of EAC risk with heme iron and processed meat intake, with HR: 1.67, 95% CI: 1.05-2.68 and HR: 2.27, 95% CI:1.33-3.89 respectively for comparison of the highest vs. lowest tertile of intake Our results suggest a potential association between higher intakes of processed meat and heme iron and risk of EAC. © 2013 Wiley Periodicals, Inc.

Published
2013

33. Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition

Author

Rohrmann, Sabine Overvad, Kim Bueno-de-Mesquita, H. Bas and Jakobsen, Marianne U. Egeberg, Rikke Tjonneland, Anne and Nailler, Laura Boutron-Ruault, Marie-Christine Clavel-Chapelon, Francoise Krogh, Vittorio Palli, Domenico Panico, Salvatore and Tumino, Rosario Ricceri, Fulvio Bergmann, Manuela M. and Boeing, Heiner Li, Kuanrong Kaaks, Rudolf Khaw, Kay-Tee and Wareham, Nicholas J. Crowe, Francesca L. Key, Timothy J. and Naska, Androniki Trichopoulou, Antonia Trichopoulos, Dimitirios and Leenders, Max Peeters, Petra H. M. Engeset, Dagrun Parr, Christine L. Skeie, Guri Jakszyn, Paula Sanchez, Maria-Jose and Huerta, Jose M. Luisa Redondo, M. Barricarte, Aurelio and Amiano, Pilar Drake, Isabel Sonestedt, Emily Hallmans, Goran and Johansson, Ingegerd Fedirko, Veronika Romieux, Isabelle and Ferrari, Pietro Norat, Teresa Vergnaud, Anne C. Riboli, Elio and Linseisen, Jakob

Abstract

Background: Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Included in the analysis were 448,568 men and women without prevalent cancer, stroke, or myocardial infarction, and with complete information on diet, smoking, physical activity and body mass index, who were between 35 and 69 years old at baseline. Cox proportional hazards regression was used to examine the association of meat consumption with all-cause and cause-specific mortality. Results: As of June 2009, 26,344 deaths were observed. After multivariate adjustment, a high consumption of red meat was related to higher all-cause mortality (hazard ratio (HR) = 1.14, 95% confidence interval (CI) 1.01 to 1.28, 160+ versus 10 to 19.9 g/day), and the association was stronger for processed meat (HR = 1.44, 95% CI 1.24 to 1.66, 160+ versus 10 to 19.9 g/day). After correction for measurement error, higher all-cause mortality remained significant only for processed meat (HR = 1.18, 95% CI 1.11 to 1.25, per 50 g/d). We estimated that 3.3% (95% CI 1.5% to 5.0%) of deaths could be prevented if all participants had a processed meat consumption of less than 20 g/day. Significant associations with processed meat intake were observed for cardiovascular diseases, cancer, and ‘other causes of death’. The consumption of poultry was not related to all-cause mortality. Conclusions: The results of our analysis support a moderate positive association between processed meat consumption and mortality, in particular due to cardiovascular diseases, but also to cancer.

Published
2013

34. Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Author

Duell, Eric J. Travier, Noemie Lujan-Barroso, Leila Dossus, Laure Boutron-Ruault, Marie-Christine Clavel-Chapelon, Francoise and Tumino, Rosario Masala, Giovanna Krogh, Vittorio Panico, Salvatore Ricceri, Fulvio Luisa Redondo, Maria Dorronsoro, Miren Molina-Montes, Esther Huerta, Jose M. Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nick J. Allen, Naomi E. and Travis, Ruth Siersema, Peter D. Peeters, Petra H. M. and Trichopoulou, Antonia Fragogeorgi, Eirini Oikonomou, Eleni and Boeing, Heiner Schuetze, Madlen Canzian, Federico Lukanova, Annekatrin Tjonneland, Anne Roswall, Nina Overvad, Kim and Weiderpass, Elisabete Gram, Inger Torhild Lund, Eiliv and Lindkvist, Bjorn Johansen, Dorthe Ye, Weimin Sund, Malin and Fedirko, Veronika Jenab, Mazda Michaud, Dominique S. Riboli, Elio Bueno-de-Mesquita, H. Bas

Abstract

Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (

Published
2013

35. Longitudinal changes in weight in relation to smoking cessation in participants of the EPIC-PANACEA study

Author

Travier, Noemie Agudo, Antonio May, Anne M. Gonzalez, Carlos and Luan, Jian'an Wareham, Nick J. Bueno-de-Mesquita, H. Bas and van den Berg, Saskia W. Slimani, Nadia Rinaldi, Sabina and Clavel-Chapelon, Francoise Boutron-Ruault, Marie-Christine and Palli, Domenico Sieri, Sabina Mattiello, Amalia Tumino, Rosario Vineis, Paolo Norat, Teresa Romaguera, Dora and Rodriguez, Laudina Sanchez, Maria-Jose Dorronsoro, Miren and Barricarte, Aurelio Huerta, Jose M. Key, Tim J. Orfanos, Philippos Naska, Androniki Trichopoulou, Antonia Rohrmann, Sabina Kaaks, Rudolf Bergmann, Manuela M. Boeing, Heiner and Hallmans, Goran Johansson, Ingegerd Manjer, Jonas Lindkvist, Bjorn Jakobsen, Mariane U. Overvad, Kim Tjonneland, Anne and Halkjaer, Jytte Lund, Eiliv Braaten, Toni Odysseos, Andreani and Riboli, Elio Peeters, Petra H.

Abstract

Purpose. We assessed the association between smoking cessation and prospective weight change in the European population of the European Prospective Investigation into Cancer and Nutrition-Physical Activity, Nutrition, Alcohol, Cessation of smoking. Eating out of home And obesity (EPIC-PANACEA) project. Methods. The study involved more than 300,000 healthy volunteers, recruited between 1992 and 2000 in 9 European countries, who provided data on anthropometry and smoking habits at baseline and after a follow-up of 5 years on average. Adjusted mixed-effects linear regression models were used to obtain sex-specific summary estimates of the association between the change in smoking status and the annual change in weight. Results. Smoking cessation tends to be followed by weight gain; when compared to stable smokers, annual weight gain was higher in men (0.44 kg (95%CI: 0.36; 0.52)) and women (0.46 kg (95%CI: 0.41; 0.52)) who stopped smoking during follow-up. When smokers who stopped smoking at least 1 year before recruitment were compared to never smokers, no major differences in annual weight gain were observed. The excess weight gain following smoking cessation appears to mainly occur in the first years following the cessation. Conclusions. When considering the benefits of smoking cessation, such findings strengthen the need for promoting cessation offering information on weight gain control and support to weight-concerned smokers in order to remove a barrier to quitting. (C) 2011 Elsevier Inc. All rights reserved.

Published
2012

36. Nitrosamines and Heme Iron and Risk of Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Jakszyn, Paula G. Allen, Naomi E. Lujan-Barroso, Leila and Gonzalez, Carlos A. Key, Timothy J. Fonseca-Nunes, Ana and Tjonneland, Anne Fons-Johnsen, Nina Overvad, Kim Teucher, Birgit Li, Kuanrong Boeing, Heiner Trichopoulou, Antonia and Oikonomou, Eleni Sarantopoulou, Maria Saieva, Calogero and Krogh, Vittorio Tumino, Rosario Ricceri, Fulvio and Bueno-de-Mesquita, H. Bas Huerta, Jose M. Ardanaz, Eva and Arguelles, Marcial V. Molina-Montes, Esther Larranaga, Nerea and Wirfaelt, Elisabet Wallstrom, Peter Johansson, Mattias and Stattin, Paer Khaw, Kay-Tee Jenab, Mazda Fedirko, Veronika and Riboli, Elio

Abstract

Background: The evidence about nitrosamines and heme iron intake and cancer risk is limited, despite the biologic plausibility of the hypothesis that these factors might increase cancer risk. We investigated the association between dietary nitrosamines and heme iron and the risk of prostate cancer among participants of European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Data on food consumption and complete follow-up for cancer occurrence was available for 139,005 men, recruited in 8 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, and study center, and adjusted for total energy intake, smoking status, marital status, dairy products, educational level, and body mass index. Results: After a mean follow-up of 10 years, 4,606 participants were diagnosed with first incident prostate cancer. There was no overall association between prostate cancer risk and nitrosamines exposure (preformed and endogenous) or heme iron intake (HR for a doubling of intake: 1.00; 95% CI: 0.98-1.03 for N-Nitrosodimethlyamine, 0.95; 95% CI: 0.88-1.03 for endogenous Nitrosocompounds, and 1.00; 95 CI: 0.97-1.03 for heme iron). Conclusions and Impact: Our findings do not support an effect of nitrosamines (endogenous and exogenous) and heme iron intake on prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 21(3); 547-51. (C) 2012 AACR.

Published
2012

37. Plasma Phospholipid Long-Chain n-3 Polyunsaturated Fatty Acids and Body Weight Change

Author

Jakobsen, Marianne U. Dethlefsen, Claus Due, Karen M. and Slimani, Nadia Chajes, Veronique May, Anne M. Sorensen, Thorkild I. A. Halkjaer, Jytte Tjonneland, Anne and Clavel-Chapelon, Francoise Boutron-Ruault, Marie-Christine and Fagherazzi, Guy Teucher, Birgit Kaaks, Rudolf Boeing, Heiner and Schuetze, Madlen Trichopoulou, Antonia Zylis, Dimosthenis and Makrygiannis, George Palli, Domenico Mattiello, Amalia and Tagliabue, Giovanna van der A, Daphne L. Bueno-de-Mesquita, H. B. Rodriguez, Laudina Travier, Noemie Molina-Montes, Esther and Huerta, Jose M. Barricarte, Aurelio Amiano, Pilar and Manjer, Jonas Wirfalt, Elisabet Johansson, Ingegerd and Hallmans, Goran Khaw, Kay-Tee Wareham, Nicholas J. Crowe, Francesca Romieu, Isabelle Riboli, Elio Peeters, Petra H. M. and Overvad, Kim

Subjects
lipids (amino acids, peptides, and proteins), sense organs
Abstract

Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

Published
2011

38. Polymorphisms of H. pylori signaling pathway genes and gastric cancer risk in the European EPIC-eurgast cohort

Author

Companioni, Osmel, Bonet, Catalina, Muñoz, Xavier, Weiderpass, Elisabete, Panico, Salvatore, Tumino, Rosario, Palli, Domenico, Agnoli, Claudia, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Racine, Antoine, Clavel-Chapelon, Françoise, Travis, Ruth C, Khaw, Kay-Tee, Riboli, Elio, Murphy, Neil, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Benetou, Vassiliki, Trichopoulos, Dimitrios, Lund, Eiliv, Johansen, Dorthe, Lindkvist, Björn, Johansson, Mattias, Sund, Malin, Ardanaz, Eva, Sánchez-Cantalejo, Emilio, Huerta, Jose M, Dorronsoro, Miren, Quirós, José Ramón, Tjonneland, Anne, Mortensen, Lotte Maxild, Overvad, Kim, Chang-Claude, Jenny, Rizzato, Cosmeri, Boeing, Heiner, de Mesquita, H Bas Bueno, Siersema, Peter, Peeters, Petra Hm, Numans, Mattijs E, Carneiro, Fatima, Licaj, Idlir, Freisling, Heinz, Sala, Núria, González, Carlos A, Companioni, Osmel, Bonet, Catalina, Muñoz, Xavier, Weiderpass, Elisabete, Panico, Salvatore, Tumino, Rosario, Palli, Domenico, Agnoli, Claudia, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Racine, Antoine, Clavel-Chapelon, Françoise, Travis, Ruth C, Khaw, Kay-Tee, Riboli, Elio, Murphy, Neil, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Benetou, Vassiliki, Trichopoulos, Dimitrios, Lund, Eiliv, Johansen, Dorthe, Lindkvist, Björn, Johansson, Mattias, Sund, Malin, Ardanaz, Eva, Sánchez-Cantalejo, Emilio, Huerta, Jose M, Dorronsoro, Miren, Quirós, José Ramón, Tjonneland, Anne, Mortensen, Lotte Maxild, Overvad, Kim, Chang-Claude, Jenny, Rizzato, Cosmeri, Boeing, Heiner, de Mesquita, H Bas Bueno, Siersema, Peter, Peeters, Petra Hm, Numans, Mattijs E, Carneiro, Fatima, Licaj, Idlir, Freisling, Heinz, Sala, Núria, and González, Carlos A

Abstract

Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccaride and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. SNPs in these genes have been associated with GC in different populations. We genotyped 30 SNPs of these genes, in 365 gastric adenocarcinomas and 1284 matched controls from the EPIC cohort. The association with GC and its histological and anatomical subtypes was analyzed by logistic regression and corrected for multiple comparisons. Using a log-additive model we found a significant association between SNPs in CD14, NOD2 and TLR4 with GC risk. However, after applying the multiple comparisons tests only the NOD2 region remained significant (p=0.009). Analysis according to anatomical subtypes revealed NOD2 and NFKB1 SNPs associated with noncardia GC and CD14 SNPs associated with cardia GC, while analysis according to histological subtypes showed that CD14 was associated with intestinal but not diffuse GC. The multiple comparisons tests confirmed the association of NOD2 with noncardia GC (p=0.0003) and CD14 with cardia GC (p=0.01). Haplotype analysis was in agreement with single SNP results for NOD2 and CD14 genes. From these results we conclude that genetic variation in NOD2 associates with noncardia GC while variation in CD14 is associated with cardia GC., Article first published online: 13 Aug 2013

Published
2014
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39. Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106 : Results from the EPIC-EURGAST study

Author

Espinosa-Parrilla, Yolanda, Munoz, Xavier, Bonet, Catalina, Garcia, Nadia, Vencesla, Adoracion, Yiannakouris, Nikos, Naccarati, Alessio, Sieri, Sabina, Panico, Salvatore, Huerta, Jose M., Barricarte, Aurelio, Menendez, Virginia, Sanchez-Cantalejo, Emilio, Dorronsoro, Miren, Brennan, Paul, Duarte-Salles, Talita, Bueno-de-Mesquita, H. B. (As), Weiderpass, Elisabete, Lund, Eiliv, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Racine, Antoine, Numans, Mattijs E., Tumino, Rosario, Canzian, Federico, Campa, Daniele, Sund, Malin, Johansson, Mattias, Ohlsson, Bodil, Lindkvist, Bjorn, Overvad, Kim, Tjonneland, Anne, Palli, Domenico, Travis, Ruth C., Khaw, Kay-Tee, Wareham, Nick, Boeing, Heiner, Nesi, Gabriella, Riboli, Elio, Gonzalez, Carlos A., Sala, Nuria, Espinosa-Parrilla, Yolanda, Munoz, Xavier, Bonet, Catalina, Garcia, Nadia, Vencesla, Adoracion, Yiannakouris, Nikos, Naccarati, Alessio, Sieri, Sabina, Panico, Salvatore, Huerta, Jose M., Barricarte, Aurelio, Menendez, Virginia, Sanchez-Cantalejo, Emilio, Dorronsoro, Miren, Brennan, Paul, Duarte-Salles, Talita, Bueno-de-Mesquita, H. B. (As), Weiderpass, Elisabete, Lund, Eiliv, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Racine, Antoine, Numans, Mattijs E., Tumino, Rosario, Canzian, Federico, Campa, Daniele, Sund, Malin, Johansson, Mattias, Ohlsson, Bodil, Lindkvist, Bjorn, Overvad, Kim, Tjonneland, Anne, Palli, Domenico, Travis, Ruth C., Khaw, Kay-Tee, Wareham, Nick, Boeing, Heiner, Nesi, Gabriella, Riboli, Elio, Gonzalez, Carlos A., and Sala, Nuria

Abstract

MicroRNAs (miRNAs) are post-transcriptional gene regulators involved in a wide range of biological processes including tumorigenesis. Deregulation of miRNA pathways has been associated with cancer but the contribution of their genetic variability to this disorder is poorly known. We analyzed the genetic association of gastric cancer (GC) and its anatomical and histological subtypes, with 133 single-nucleotide polymorphisms (SNPs) tagging 15 isolated miRNAs and 24 miRNA clusters potentially involved in cancer, in 365 GC cases and 1,284 matched controls within the European Prospective Investigation into Cancer and Nutrition cohort. Various SNPs were associated with GC under the log-additive model. Furthermore, several of these miRNAs passed the gene-based permutation test when analyzed according to GC subtypes: three tagSNPs of the miR-29a/miR-29b-1 cluster were associated with diffuse subtype (minimum p-value=1.7 x 10(-4); odds ratio, OR=1.72; 95% confidence interval, CI=1.30-2.28), two tagSNPs of the miR-25/miR-93/miR-106b cluster were associated with cardia GC (minimum p-value=5.38 x 10(-3); OR=0.56, 95% CI=0.37-0.86) and one tagSNP of the miR-363/miR-92a-2/miR-19b-2/miR-20b/miR-18b/miR-106a cluster was associated with noncardia GC (minimum p-value=5.40 x 10(-3); OR=1.41, 95% CI=1.12-1.78). Some functionally validated target genes of these miRNAs are implicated in cancer-related processes such as methylation (DNMT3A, DNMT3B), cell cycle (E2F1, CDKN1A, CDKN1C), apoptosis (BCL2L11, MCL1), angiogenesis (VEGFA) and progression (PIK3R1, MYCN). Furthermore, we identified genetic interactions between variants tagging these miRNAs and variants in their validated target genes. Deregulation of the expression of these miRNAs in GC also supports our findings, altogether suggesting for the fist time that genetic variation in MIR29, MIR25, MIR93 and MIR106b may have a critical role in genetic susceptibility to GC and could contribute to the molecular mechanisms of gastric carcin

Published
2014
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40. Meat consumption and mortality : results from the European Prospective Investigation into Cancer and Nutrition

Author

Rohrmann, Sabine, Overvad, Kim, Bueno-de-Mesquita, H Bas, Jakobsen, Marianne U, Egeberg, Rikke, Tjonneland, Anne, Nailler, Laura, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Krogh, Vittorio, Palli, Domenico, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Bergmann, Manuela M, Boeing, Heiner, Li, Kuanrong, Kaaks, Rudolf, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca L, Key, Timothy J, Naska, Androniki, Trichopoulou, Antonia, Trichopoulos, Dimitirios, Leenders, Max, Peeters, Petra HM, Engeset, Dagrun, Parr, Christine L, Skeie, Guri, Jakszyn, Paula, Sanchez, Maria-Jose, Huerta, Jose M, Luisa Redondo, M, Barricarte, Aurelio, Amiano, Pilar, Drake, Isabel, Sonestedt, Emily, Hallmans, Göran, Johansson, Ingegerd, Fedirko, Veronika, Romieux, Isabelle, Ferrari, Pietro, Norat, Teresa, Vergnaud, Anne C, Riboli, Elio, Linseisen, Jakob, Rohrmann, Sabine, Overvad, Kim, Bueno-de-Mesquita, H Bas, Jakobsen, Marianne U, Egeberg, Rikke, Tjonneland, Anne, Nailler, Laura, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Krogh, Vittorio, Palli, Domenico, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Bergmann, Manuela M, Boeing, Heiner, Li, Kuanrong, Kaaks, Rudolf, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca L, Key, Timothy J, Naska, Androniki, Trichopoulou, Antonia, Trichopoulos, Dimitirios, Leenders, Max, Peeters, Petra HM, Engeset, Dagrun, Parr, Christine L, Skeie, Guri, Jakszyn, Paula, Sanchez, Maria-Jose, Huerta, Jose M, Luisa Redondo, M, Barricarte, Aurelio, Amiano, Pilar, Drake, Isabel, Sonestedt, Emily, Hallmans, Göran, Johansson, Ingegerd, Fedirko, Veronika, Romieux, Isabelle, Ferrari, Pietro, Norat, Teresa, Vergnaud, Anne C, Riboli, Elio, and Linseisen, Jakob

Abstract

Background: Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Included in the analysis were 448,568 men and women without prevalent cancer, stroke, or myocardial infarction, and with complete information on diet, smoking, physical activity and body mass index, who were between 35 and 69 years old at baseline. Cox proportional hazards regression was used to examine the association of meat consumption with all-cause and cause-specific mortality. Results: As of June 2009, 26,344 deaths were observed. After multivariate adjustment, a high consumption of red meat was related to higher all-cause mortality (hazard ratio (HR) = 1.14, 95% confidence interval (CI) 1.01 to 1.28, 160+ versus 10 to 19.9 g/day), and the association was stronger for processed meat (HR = 1.44, 95% CI 1.24 to 1.66, 160+ versus 10 to 19.9 g/day). After correction for measurement error, higher all-cause mortality remained significant only for processed meat (HR = 1.18, 95% CI 1.11 to 1.25, per 50 g/d). We estimated that 3.3% (95% CI 1.5% to 5.0%) of deaths could be prevented if all participants had a processed meat consumption of less than 20 g/day. Significant associations with processed meat intake were observed for cardiovascular diseases, cancer, and 'other causes of death'. The consumption of poultry was not related to all-cause mortality. Conclusions: The results of our analysis support a moderate positive association between processed meat consumption and mortality, in particular due to cardiovascular diseases, but also to cancer.

Published
2013
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41. Fish consumption and subsequent change in body weight in European women and men

Author

Jakobsen, Marianne U., Dethlefsen, Claus, Due, Karen M., May, Anne M., Romaguera, Dora, Vergnaud, Anne-Claire, Norat, Teresa, Sorensen, Thorkild I. A., Halkjaer, Jytte, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Fagherazzi, Guy, Teucher, Birgit, Kuehn, Tilman, Bergmann, Manuela M., Boeing, Heiner, Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Palli, Domenico, De Magistris, Maria Santucci, Sieri, Sabina, Bueno-de-Mesquita, H. B., van der A, Daphne L., Engeset, Dagrun, Hjartaker, Anette, Rodriguez, Laudina, Agudo, Antonio, Molina-Montes, Esther, Huerta, Jose M., Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfalt, Elisabet, Hallmans, Göran, Johansson, Ingegerd, Khaw, Kay-Tee, Wareham, Nicholas J., Key, Timothy J., Chajes, Veronique, Slimani, Nadia, Riboli, Elio, Peeters, Petra H. M., Overvad, Kim, Jakobsen, Marianne U., Dethlefsen, Claus, Due, Karen M., May, Anne M., Romaguera, Dora, Vergnaud, Anne-Claire, Norat, Teresa, Sorensen, Thorkild I. A., Halkjaer, Jytte, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Fagherazzi, Guy, Teucher, Birgit, Kuehn, Tilman, Bergmann, Manuela M., Boeing, Heiner, Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Palli, Domenico, De Magistris, Maria Santucci, Sieri, Sabina, Bueno-de-Mesquita, H. B., van der A, Daphne L., Engeset, Dagrun, Hjartaker, Anette, Rodriguez, Laudina, Agudo, Antonio, Molina-Montes, Esther, Huerta, Jose M., Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfalt, Elisabet, Hallmans, Göran, Johansson, Ingegerd, Khaw, Kay-Tee, Wareham, Nicholas J., Key, Timothy J., Chajes, Veronique, Slimani, Nadia, Riboli, Elio, Peeters, Petra H. M., and Overvad, Kim

Abstract

Fish consumption is the major dietary source of EPA and DHA, which according to rodent experiments may reduce body fat mass and prevent obesity. Only a few human studies have investigated the association between fish consumption and body-weight gain. We investigated the association between fish consumption and subsequent change in body weight. Women and men (n 344 757) participating in the European Prospective Investigation into Cancer and Nutrition were followed for a median of 5.0 years. Linear and logistic regression were used to investigate the associations between fish consumption and subsequent change in body weight. Among women, the annual weight change was 5.70 (95% CI 4.35, 7.06), 2.23 (95% CI 0.16, 4.31) and 11.12 (95% CI 8.17, 14.08) g/10 g higher total, lean and fatty fish consumption per d, respectively. The OR of becoming overweight in 5 years among women who were normal weight at enrolment was 1.02 (95% CI 1.01, 1.02), 1.01 (95% CI 1.00, 1.02) and 1.02 (95% CI 1.01, 1.04) g/10 g higher total, lean and fatty consumption per d, respectively. Among men, fish consumption was not statistically significantly associated with weight change. Adjustment for potential over-or underestimation of fish consumption did not systematically change the observed associations, but the 95% CI became wider. The results in subgroups from analyses stratified by age or BMI at enrolment were not systematically different. In conclusion, the present study suggests that fish consumption has no appreciable association with body-weight gain.

Published
2013
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42. Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Author

Duell, Eric J., Travier, Noemie, Lujan-Barroso, Leila, Dossus, Laure, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Tumino, Rosario, Masala, Giovanna, Krogh, Vittorio, Panico, Salvatore, Ricceri, Fulvio, Luisa Redondo, Maria, Dorronsoro, Miren, Molina-Montes, Esther, Huerta, Jose M., Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick J., Allen, Naomi E., Travis, Ruth, Siersema, Peter D., Peeters, Petra H. M., Trichopoulou, Antonia, Fragogeorgi, Eirini, Oikonomou, Eleni, Boeing, Heiner, Schuetze, Madlen, Canzian, Federico, Lukanova, Annekatrin, Tjonneland, Anne, Roswall, Nina, Overvad, Kim, Weiderpass, Elisabete, Gram, Inger Torhild, Lund, Eiliv, Lindkvist, Bjorn, Johansen, Dorthe, Ye, Weimin, Sund, Malin, Fedirko, Veronika, Jenab, Mazda, Michaud, Dominique S., Riboli, Elio, Bueno-de-Mesquita, H. Bas, Duell, Eric J., Travier, Noemie, Lujan-Barroso, Leila, Dossus, Laure, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Tumino, Rosario, Masala, Giovanna, Krogh, Vittorio, Panico, Salvatore, Ricceri, Fulvio, Luisa Redondo, Maria, Dorronsoro, Miren, Molina-Montes, Esther, Huerta, Jose M., Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick J., Allen, Naomi E., Travis, Ruth, Siersema, Peter D., Peeters, Petra H. M., Trichopoulou, Antonia, Fragogeorgi, Eirini, Oikonomou, Eleni, Boeing, Heiner, Schuetze, Madlen, Canzian, Federico, Lukanova, Annekatrin, Tjonneland, Anne, Roswall, Nina, Overvad, Kim, Weiderpass, Elisabete, Gram, Inger Torhild, Lund, Eiliv, Lindkvist, Bjorn, Johansen, Dorthe, Ye, Weimin, Sund, Malin, Fedirko, Veronika, Jenab, Mazda, Michaud, Dominique S., Riboli, Elio, and Bueno-de-Mesquita, H. Bas

Abstract

Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (<12 vs. 13 years) was moderately associated with an increased risk of pancreatic cancer in the full cohort; however, this result was marginally significant (HR = 1.44; 95% CI = 0.992.10). CYP17A1 rs619824 was associated with HRT use (p value = 0.037) in control women; however, none of the SNPs alone, in combination, or as haplotypes were associated with pancreatic cancer risk. In conclusion, with the possible exception of an early age of menarche, none of the menstrual and reproductive factors, and none of the 12 common genetic variants we evaluated at the CYP17A1 locus makes a substantial contribution to pancreatic cancer susceptibility in the EPIC cohort.

Published
2013
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43. Polymorphisms ofHelicobacter pylorisignaling pathway genes and gastric cancer risk in the European prospective investigation into cancer-eurgast cohort

Author

Companioni, Osmel, primary, Bonet, Catalina, additional, Muñoz, Xavier, additional, Weiderpass, Elisabete, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Vineis, Paolo, additional, Boutron-Ruault, Marie-Christine, additional, Racine, Antoine, additional, Clavel-Chapelon, Françoise, additional, Travis, Ruth C., additional, Khaw, Kay-Tee, additional, Riboli, Elio, additional, Murphy, Neil, additional, Vergnaud, Anne-Claire, additional, Trichopoulou, Antonia, additional, Benetou, Vassiliki, additional, Trichopoulos, Dimitrios, additional, Lund, Eiliv, additional, Johansen, Dorthe, additional, Lindkvist, Björn, additional, Johansson, Mattias, additional, Sund, Malin, additional, Ardanaz, Eva, additional, Sánchez-Cantalejo, Emilio, additional, Huerta, Jose M., additional, Dorronsoro, Miren, additional, Ramón Quirós, José, additional, Tjonneland, Anne, additional, Maxild Mortensen, Lotte, additional, Overvad, Kim, additional, Chang-Claude, Jenny, additional, Rizzato, Cosmeri, additional, Boeing, Heiner, additional, de Mesquita, H. Bas Bueno, additional, Siersema, Peter, additional, Peeters, Petra H.M., additional, Numans, Mattijs E., additional, Carneiro, Fatima, additional, Licaj, Idlir, additional, Freisling, Heinz, additional, Sala, Núria, additional, and González, Carlos A., additional

Published
2013
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49. Assessment of the Effects of Marine Aggregate Extraction on the Coastline: an Example from the German Baltic Sea Coast.

Author

Kortekaas, Stella, Bagdanaviciute, Ingrida, Gyssels, Paolo, Alonso Huerta, Jose M., and Héqueue, Arnaud

Subjects
SEDIMENT transport, HOLOCENE stratigraphic geology, SAND
Abstract

The German Baltic Sea coast between Warnemünde and Darss is rapidly eroding. In this area, extensive sand extraction takes place at water depths of 8-13 m, for both local beach nourishment and industrial use. Sand resources in the area are restricted to a layer of <2 m of Holocene sand, whilst contemporary input of sand is limited to erosion of the cliff sections. To investigate if sand extraction in this area has any effect on the coastline, bathymetric data from two particular time periods were compared, as well as the location of the coastline over 5 different years, ranging from 1953-2002. Waves and wave-induced sediment transport were simulated using the integrated coastal zone model, Sistema de Modelado Costero (SMC). Results indicate some primary areas of concern: small changes in bathymetry of approximately 10% are sufficient to cause significant modifications in sediment transport potential at the coast; and, thus, alternations in the patterns of erosion and accretion. Sediment transport by both wave action and currents, induced by the inflow of North Sea water, is in a NE direction towards Darss. Here, deposition takes place in a National Park, where dredging is prohibited. There is very little input of sediment in the system. Any sand that is removed by marine aggregate extraction, for industrial use, will have a negative effect on the total sediment budget at the shoreline. [ABSTRACT FROM AUTHOR]

Published
2010
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