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2. T2EVOLVE: STANDARDIZATION OF PRE-CLINICAL AND CLINICAL DEVELOPMENT OF ENGINEERED T CELL THERAPY IN EUROPE; A CROSS FUNCTIONAL MULTI STAKEHOLDER INITIATIVE

Author

Luu, M., primary, Sanges, C., additional, Dreuillet, C., additional, Pennings, E., additional, Casucci, M., additional, Franz, P., additional, Donnadieu, E., additional, Quintarelli, C., additional, Guedan, S., additional, Kersten, M., additional, Morris, E., additional, Ivics, Z., additional, Jager, U., additional, Busch, D.H., additional, Gonzalez, E., additional, Paiva, B., additional, Schröder, B., additional, Chu, L., additional, Cabrizo, Y., additional, Ammar, D., additional, Junius, S., additional, Philippar, U., additional, Fleischer, A., additional, Awigena-Cook, J., additional, Schapitz, I., additional, Henderson, D., additional, Kremer, A., additional, Wagers, S., additional, Choudhary, R., additional, and Hudecek, M., additional

Published
2024
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3. Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA)

Author

Hayden, P.J., Roddie, C., Bader, P., Basak, G.W., Bonig, H., Bonini, C., Chabannon, C., Ciceri, F., Corbacioglu, S., Ellard, R., Sanchez-Guijo, F., Jäger, U., Hildebrandt, M., Hudecek, M., Kersten, M.J., Köhl, U., Kuball, J., Mielke, S., Mohty, M., Murray, J., Nagler, A., Rees, J., Rioufol, C., Saccardi, R., Snowden, J.A., Styczynski, J., Subklewe, M., Thieblemont, C., Topp, M., Ispizua, Á.U., Chen, D., Vrhovac, R., Gribben, J.G., Kröger, N., Einsele, H., and Yakoub-Agha, I.

Published
2022
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4. Social and moral psychology of COVID-19 across 69 countries

Author

Azevedo, F, Pavlovic, T, Rego, G, Ay, F, Gjoneska, B, Etienne, T, Ross, R, Schonegger, P, Riano-Moreno, J, Cichocka, A, Capraro, V, Cian, L, Longoni, C, Chan, H, Van Bavel, J, Sjastad, H, Nezlek, J, Alfano, M, Gelfand, M, Birtel, M, Cislak, A, Lockwood, P, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomoki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, White, K, Habib, R, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Sampaio, W, Azevedo F., Pavlovic T., Rego G. G., Ay F. C., Gjoneska B., Etienne T. W., Ross R. M., Schonegger P., Riano-Moreno J. C., Cichocka A., Capraro V., Cian L., Longoni C., Chan H. F., Van Bavel J. J., Sjastad H., Nezlek J. B., Alfano M., Gelfand M. J., Birtel M. D., Cislak A., Lockwood P. L., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O. M., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., de Mello V. O., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomoki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., White K., Habib R., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., Boggio P. S., Sampaio W. M., Azevedo, F, Pavlovic, T, Rego, G, Ay, F, Gjoneska, B, Etienne, T, Ross, R, Schonegger, P, Riano-Moreno, J, Cichocka, A, Capraro, V, Cian, L, Longoni, C, Chan, H, Van Bavel, J, Sjastad, H, Nezlek, J, Alfano, M, Gelfand, M, Birtel, M, Cislak, A, Lockwood, P, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomoki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, White, K, Habib, R, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Sampaio, W, Azevedo F., Pavlovic T., Rego G. G., Ay F. C., Gjoneska B., Etienne T. W., Ross R. M., Schonegger P., Riano-Moreno J. C., Cichocka A., Capraro V., Cian L., Longoni C., Chan H. F., Van Bavel J. J., Sjastad H., Nezlek J. B., Alfano M., Gelfand M. J., Birtel M. D., Cislak A., Lockwood P. L., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O. M., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., de Mello V. O., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomoki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., White K., Habib R., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., Boggio P. S., and Sampaio W. M.

Abstract

The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.

Published
2023

7. National identity predicts public health support during a global pandemic

Author

Van Bavel, J, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, J, Pavlovic, T, Alfano, M, Gelfand, M, Azevedo, F, Birtel, M, Cislak, A, Lockwood, P, Ross, R, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Riano-Moreno, J, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ay, F, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Etienne, T, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Longoni, C, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, G, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, W, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schonegger, P, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Van Bavel J. J., Cichocka A., Capraro V., Sjastad H., Nezlek J. B., Pavlovic T., Alfano M., Gelfand M. J., Azevedo F., Birtel M. D., Cislak A., Lockwood P. L., Ross R. M., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gjoneska B., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Riano-Moreno J. C., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ay F. C., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cian L., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Etienne T. W., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Longoni C., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., Oldemburgo de Mello V., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomaki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rego G. G., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Sampaio W. M., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schonegger P., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., Boggio P. S., Van Bavel, J, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, J, Pavlovic, T, Alfano, M, Gelfand, M, Azevedo, F, Birtel, M, Cislak, A, Lockwood, P, Ross, R, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Riano-Moreno, J, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ay, F, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Etienne, T, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Longoni, C, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, G, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, W, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schonegger, P, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Van Bavel J. J., Cichocka A., Capraro V., Sjastad H., Nezlek J. B., Pavlovic T., Alfano M., Gelfand M. J., Azevedo F., Birtel M. D., Cislak A., Lockwood P. L., Ross R. M., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gjoneska B., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Riano-Moreno J. C., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ay F. C., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cian L., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Etienne T. W., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Longoni C., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., Oldemburgo de Mello V., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomaki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rego G. G., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Sampaio W. M., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schonegger P., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., and Boggio P. S.

Abstract

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.

Published
2022

9. Immunotherapy: IN-DEPTH CHARACTERIZATION OF THE IMMUNE MICROENVIRONMENT OF PATIENTS UNDERGOING CAR T CELL THERAPY

Author

Weirauch, U., primary, Alb, M., additional, Weiß, R., additional, Löffler, D., additional, Kopfnagel, V., additional, Blumert, C., additional, Düll, J., additional, Scheller, L., additional, Boldt, A., additional, Vucinic, V., additional, Platzbecker, U., additional, Köhl, U., additional, Hudecek, M., additional, and Reiche, K., additional

Published
2023
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10. Process Development and Manufacturing: OUTCOMES OF THE T2EVOLVE EUROPEAN SURVEY ON CAR T CELL ANALYTICAL METHODS FROM APHERESIS TO POST-INFUSION IMMUNOMONITORING

Author

Lecot, P., primary, Courcault, E., additional, Neininger, K., additional, Lorrain, M., additional, Gambotti, L., additional, Dreuillet, C., additional, Chatterjee, S., additional, Locatelli, F., additional, Luu, M., additional, Sanges, C., additional, Hudecek, M., additional, Kremer, A., additional, De Angelis, B., additional, Quintarelli, C., additional, and Negre, H., additional

Published
2023
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15. Time to evolve: predicting engineered T cell-associated toxicity with next-generation models

Author

Donnadieu, E., Luu, M., Alb, M., Anliker, B., Arcangeli, S., Bonini, C., De Angelis, B., Choudhary, R., Espie, D., Galy, A., Holland, C., Ivics, Z., Kantari-Mimoun, C., Kersten, M. J., Kohl, U., Kuhn, C., Laugel, B., Locatelli, Franco, Marchiq, I., Markman, J., Moresco, M. A., Morris, E., Negre, H., Quintarelli, C., Rade, M., Reiche, K., Renner, M., Ruggiero, E., Sanges, C., Stauss, H., Themeli, M., Van den Brulle, J., Hudecek, M., Casucci, M., Locatelli F. (ORCID:0000-0002-7976-3654), Donnadieu, E., Luu, M., Alb, M., Anliker, B., Arcangeli, S., Bonini, C., De Angelis, B., Choudhary, R., Espie, D., Galy, A., Holland, C., Ivics, Z., Kantari-Mimoun, C., Kersten, M. J., Kohl, U., Kuhn, C., Laugel, B., Locatelli, Franco, Marchiq, I., Markman, J., Moresco, M. A., Morris, E., Negre, H., Quintarelli, C., Rade, M., Reiche, K., Renner, M., Ruggiero, E., Sanges, C., Stauss, H., Themeli, M., Van den Brulle, J., Hudecek, M., Casucci, M., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Despite promising clinical results in a small subset of malignancies, therapies based on engineered chimeric antigen receptor and T-cell receptor T cells are associated with serious adverse events, including cytokine release syndrome and neurotoxicity. These toxicities are sometimes so severe that they significantly hinder the implementation of this therapeutic strategy. For a long time, existing preclinical models failed to predict severe toxicities seen in human clinical trials after engineered T-cell infusion. However, in recent years, there has been a concerted effort to develop models, including humanized mouse models, which can better recapitulate toxicities observed in patients. The Accelerating Development and Improving Access to CAR and TCR-engineered T cell therapy (T2EVOLVE) consortium is a public-private partnership directed at accelerating the preclinical development and increasing access to engineered T-cell therapy for patients with cancer. A key ambition in T2EVOLVE is to design new models and tools with higher predictive value for clinical safety and efficacy, in order to improve and accelerate the selection of lead T-cell products for clinical translation. Herein, we review existing preclinical models that are used to test the safety of engineered T cells. We will also highlight limitations of these models and propose potential measures to improve them.

Published
2022

16. Management of Adults and Children receiving CAR T-cell therapy: 2021 Best Practice Recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA)

Author

CTI Kuball, MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, Hayden, P J, Roddie, C, Bader, P, Basak, G W, Bonig, H, Bonini, C, Chabannon, C, Ciceri, F, Corbacioglu, S, Ellard, R, Sanchez-Guijo, F, Jäger, U, Hildebrandt, M, Hudecek, M, Kersten, M J, Köhl, U, Kuball, J, Mielke, S, Mohty, M, Murray, J, Nagler, A, Rees, J, Rioufol, C, Saccardi, R, Snowden, J A, Styczynski, J, Subklewe, M, Thieblemont, C, Topp, M, Ispizua, Á U, Chen, D, Vrhovac, R, Gribben, J G, Kröger, N, Einsele, H, Yakoub-Agha, I, CTI Kuball, MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, Hayden, P J, Roddie, C, Bader, P, Basak, G W, Bonig, H, Bonini, C, Chabannon, C, Ciceri, F, Corbacioglu, S, Ellard, R, Sanchez-Guijo, F, Jäger, U, Hildebrandt, M, Hudecek, M, Kersten, M J, Köhl, U, Kuball, J, Mielke, S, Mohty, M, Murray, J, Nagler, A, Rees, J, Rioufol, C, Saccardi, R, Snowden, J A, Styczynski, J, Subklewe, M, Thieblemont, C, Topp, M, Ispizua, Á U, Chen, D, Vrhovac, R, Gribben, J G, Kröger, N, Einsele, H, and Yakoub-Agha, I

Published
2022

18. High antileukemic efficiency of CD19-CAR NK cells engineered with Sleeping Beauty transposon vectors

Author

Bexte, T, additional, Botezatu, L, additional, Miskey, C, additional, Reindl, LM, additional, Campe, J, additional, Mertlitz, S, additional, Gebel, V, additional, Schubert, R, additional, Cremer, A, additional, Rettinger, E, additional, Prommersberger, S, additional, Penack, O, additional, Wels, WS, additional, Hudecek, M, additional, Ivics, Z, additional, and Ullrich, E, additional

Published
2022
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21. Management of adults and children receiving CAR T- cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA)

Author

Hayden, PJ, Roddie, C, Bader, P, Basak, GW, Bonig, H, Bonini, C, Chabannon, C, Ciceri, F, Corbacioglu, S, Ellard, R, Sanchez-Guijo, F, Jäger, U, Hildebrandt, M, Hudecek, M, Kersten, MJ, Köhl, U, Kuball, J, Mielke, S, Mohty, M, Murray, J, Nagler, A, Rees, J, Rioufol, C, Saccardi, R, Snowden, JA, Styczynski, J, Subklewe, M, Thieblemont, C, Topp, M, Ispizua, ÁU, Chen, D, Vrhovac, Radovan, Gribben, JG, Kröger, N, Einsele, H, and Yakoub-Agha, I

Subjects
CAR T-cell therapy, best practice recommendations
Abstract

Background: Several commercial and academic autologous chimeric antigen receptor T-cell (CAR-T) products targeting CD19 have been approved in Europe for relapsed/refractory B-cell acute lymphoblastic leukemia, high-grade B-cell lymphoma and mantle cell lymphoma. Products for other diseases such as multiple myeloma and follicular lymphoma are likely to be approved by the European Medicines Agency in the near future. Design: The European Society for Blood and Marrow Transplantation (EBMT)-Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association collaborated to draft best practice recommendations based on the current literature to support health care professionals in delivering consistent, high-quality care in this rapidly moving field. Results: Thirty-six CAR-T experts (medical, nursing, pharmacy/laboratory) assembled to draft recommendations to cover all aspects of CAR-T patient care and supply chain management, from patient selection to long-term follow-up, post- authorisation safety surveillance and regulatory issues. Conclusions: We provide practical, clinically relevant recommendations on the use of these high- cost, logistically complex therapies for haematologists/oncologists, nurses and other stakeholders including pharmacists and health sector administrators involved in the delivery of CAR-T in the clinic. Keywords: B-cell acute lymphoblastic leukemia (B ALL) ; CAR T-cells ; cytokine release syndrome (CRS) ; immune effector cell associated neurotoxicity syndrome (ICANS) ; large B-cell lymphoma (LBCL) ; multiple myeloma (MM).

Published
2022

22. Characterisation of heterogeneous antigen-expression pattern comparing glioblastoma cell lines, patient-derived cells and patients’ glioblastoma tissue

Author

Dufner, V, Schulz, E, Monoranu, C, Hudecek, M, Hagemann, C, Ernestus, RI, Löhr, M, and Nerreter, T

Subjects
ddc: 610, 610 Medical sciences, Medicine, nervous system diseases
Abstract

Objective: Immunotherapeutic treatment of glioblastoma (GBM) is one of the most challenging tasks due to heterogeneous surface expression of target antigens. It has previously been reported that GBM cell lines (GCL), patient-derived cells (PDC) and patients’ tumour tissue (PT) differ strongly[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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24. Beneficial role of CD8+T-cell reconstitution after HLA-haploidentical stem cell transplantation for high-risk acute leukaemias

Author

Bondanza, A., Ruggeri, L., Noviello, M., Eikema, D.J., Bonini, C., Chabannon, C., Werf, S. van der, Biezen, A. van, Wreede, L.C. de, Crucitti, L., Vago, L., Merluzzi, M., Massei, M.S., Veelken, H., Koc, Y., Bader, P., Gruhn, B., Locatelli, F., Ciceri, F., Toubert, A., Velardi, A., Bernardo, M.E., Dazzi, F., Ellard, R., Fleischhauer, K., Greco, R., Hudecek, M., Kohl, U., Kuball, J., Malard, F., Pedrazzoli, P., Rocha, V., Ruggeri, A., Urbano-Ispizua, A., Wang, J.F., Wieten, L., EBMT Cell Therapy Immunobiol Worki, Bondanza, Attilio, Ruggeri, Loredana, Noviello, Maddalena, Eikema, Dirk-Jan, Bonini, Chiara, Chabannon, Christian, van der Werf, Steffie, van Biezen, Anja, de Wreede, Liesbeth C., Crucitti, Lara, Vago, Luca, Merluzzi, Mara, Massei, Maria Speranza, Veelken, Hendrik, Koc, Yener, Bader, Peter, Gruhn, Bernd, Locatelli, Franco, Ciceri, Fabio, Toubert, Antoine, Velardi, Andrea, MUMC+: DA TI Laboratorium (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, and MUMC+: DA TI Staf (9)

Subjects
Male, Oncology, BLOOD, COUNT, Medizin, CHILDREN, CD8-Positive T-Lymphocytes, DISEASE, 0302 clinical medicine, Risk Factors, hemic and lymphatic diseases, Cytotoxic T cell, Registries, Child, INDEX, Leukemia, Hematology, Middle Aged, RECOVERY, Haematopoiesis, surgical procedures, operative, medicine.anatomical_structure, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Transplantation, Child, Preschool, 030220 oncology & carcinogenesis, HSCT, Female, Stem cell, Adult, medicine.medical_specialty, Adolescent, T cell, Human leukocyte antigen, Young Adult, 03 medical and health sciences, CD8-positive T-lymphocytes, haematopoietic stem cell transplantation, risk factors, Internal medicine, SCORE, medicine, Humans, IMMUNOTHERAPY, Aged, business.industry, ADULTS, BONE-MARROW-TRANSPLANTATION, Transplantation, Haploidentical, business, CD8, Stem Cell Transplantation, 030215 immunology, RESPONSES
Abstract

HLA-haploidentical haematopoietic stem cell transplantation (haplo-HSCT) is increasingly offered to patients with high-risk acute leukaemia. Unfortunately, haplo-HSCT is followed by a delayed immunoreconstitution. The aim of this EBMT registry study was to explore the clinical impact of lymphocyte subset counts after haplo-HSCT. We considered 144 leukaemic patients transplanted in the period 2001-2012. Pre-transplantation clinical variables and differential immune-cell counts (CD3, CD4, CD8 T cells, NK and B cells) measured before day 100 were evaluated for their capacity to predict overall survival, relapse mortality or non-relapse mortality (NRM). Negative prognostic factors for overall survival were advanced disease state at transplantation, host age and CMV seropositivity. Higher CD3, CD4 and CD8 counts were associated with a better overall survival and a lower NRM. Strikingly, when tested in multivariable analysis, higher CD3 and CD8 counts were still significantly associated with a lower NRM. These results indicate that an accelerated T-cell reconstitution correlates with less transplantation mortality, likely due to the protective role of T cells against viral infections. This observation suggests that CD8+ T-cell counts should be investigated as surrogate biomarkers of outcome in prospective haplo-HSCT trials.

Published
2019

25. Eindimensionale Skala zur Messung von Dankbarkeit (GQ-5-G)

Author

Hudecek, M. F. C., Blabst, N., Morgan, B., and Lermer, E.

Subjects
cross-cultural measurement invariance, Gratitude Questionnaire-Six Item Form, Dankbarkeit, positive psychology, Positive Psychologie, kulturelle Messinvarianz, Gratitude Questionnaire-Six Item Form | gratitude
Abstract

Die hier dokumentierte Skala zur Messung von Dankbarkeit (GQ-5-G) ist die deutschsprachige Version des Gratitude Questionnaire-Six Item Form (GQ-6). Der GQ-6 wurde ursprünglich von McCullough et al. (2002) entwickelt. Die Skala misst die emotionale Komponente von Dankbarkeit. Die hier vorgestellte Fassung besteht – wie Adaptionen für andere Sprachen auch (z. B., Bernabé-Valero et al., 2014; Chen et al., 2008; Langer et al., 2016) – aus fünf Items, die zu einem gewichteten Skalenmittelwert zusammengefasst werden. Die Validierung erfolgte mittels einer Online-Umfrage und umfasste die Daten von 508 Versuchspersonen. Der GQ-5-G verfügt über eine gute interne Konsistenz und sowohl die Konstrukt- als auch die Kriteriumsvalidität konnten nachgewiesen werden. Darüber hinaus besteht kulturelle skalare Messinvarianz mit der englischsprachigen Version (Morgan et al., 2017). Der GQ-5-G ist skalar messinvariant über Geschlechter., Zusammenstellung sozialwissenschaftlicher Items und Skalen (ZIS)

Published
2021
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26. Mehrdimensionale Skala zur Messung von Dankbarkeit (MCGM-G)

Author

Hudecek, M. F. C., Blabst, N., Morgen, B., and Lermer, E.

Subjects
Dankbarkeit, multi-component gratitude measure, positive psychology, cultural measurement invariance, kulturelle Messinvarianz | Gratitude, positive Psychologie
Abstract

Die hier dokumentierte mehrdimensionale Skala zur Messung von Dankbarkeit (MCGM-G) ist die deutschsprachige Version des Multi-Component Gratitude Measure (MCGM). Der MCGM wurde als ein ganzheitlicher Ansatz zur Messung von Dankbarkeit von Morgan et al. (2017) entwickelt und umfasst emotionale, einstellungsbezogene und verhaltensbezogene Komponenten von Dankbarkeit. Die Validierung erfolgte mittels einer Online-Umfrage und umfasste die Daten von 508 Versuchspersonen. Der MCGM-G verfügt über eine gute interne Konsistenz und sowohl die Konstrukt- als auch die Kriteriumsvalidität konnten nachgewiesen werden. Darüber hinaus besteht partielle skalare Messinvarianz (d.h. kulturelle Invarianz) mit der englischsprachigen Version für fünf der sechs Faktoren. Zudem liegt vollständige Messinvarianz hinsichtlich des Geschlechts der TeilnehmerInnen für alle Dimensionen des MCGM-G vor., Zusammenstellung sozialwissenschaftlicher Items und Skalen (ZIS)

Published
2021
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28. The EHA research Roadmap: Immune-based therapies for hematological malignancies

Author

Einsele, H., Briones, J., Ciceri, F., Cadenas, I. G., Falkenburg, F., Bolanos, N., Heemskerk, H. M. M., Houot, R., Hudecek, M., Locatelli, Franco, Morgan, K., Morris, E. C., O'Dwyer, M., Sierra, J. G., van den Brink, M., van de Loosdrecht, A. A., Locatelli F. (ORCID:0000-0002-7976-3654), Einsele, H., Briones, J., Ciceri, F., Cadenas, I. G., Falkenburg, F., Bolanos, N., Heemskerk, H. M. M., Houot, R., Hudecek, M., Locatelli, Franco, Morgan, K., Morris, E. C., O'Dwyer, M., Sierra, J. G., van den Brink, M., van de Loosdrecht, A. A., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

In 2016, the European Hematology Association (EHA) published the EHA Roadmap for European Hematology Research1 aiming to highlight achievements in the diagnostics and treatment of blood disorders, and to better inform European policy makers and other stakeholders about the urgent clinical and scientific needs and priorities in the field of hematology. Each section was coordinated by 1–2 section editors who were leading international experts in the field. In the 5 years that have followed, advances in the field of hematology have been plentiful. As such, EHA is pleased to present an updated Research Roadmap, now including 11 sections, each of which will be published separately. The updated EHA Research Roadmap identifies the most urgent priorities in hematology research and clinical science, therefore supporting a more informed, focused, and ideally a more funded future for European Hematology Research. the 11 EHA Research Roadmap sections include normal hematopoiesis; malignant lymphoid diseases; malignant myeloid diseases; anemias and related diseases; platelet disorders; blood coagulation and hemostatic disorders; transfusion medicine; infections in hematology; hematopoietic stem cell transplantation; CAR-T and Other cell-based immune therapies; and gene therapy.

Published
2021

29. Immune-based therapies for hematological malignancies: an update by the EHA SWG on immunotherapy of hematological malignancies

Author

Einsele, H., Briones, J., Ciceri, F., Garcia-Cadenas, I., Falkenburg, F., Bolanos, N., Heemskerk, H.M.M., Houot, R., Hudecek, M., Locatelli, F., Morgan, K., Morris, C.E., O'Dwyer, M., Gil, J.S., Brink, M. van den, Loosdrecht, A.A. van de, Einsele, Hermann, Briones, Javier, Ciceri, Fabio, García-Cadenas, Irene, Falkenburg, Fred, Bolaños, Natacha, Heemskerk, H. M. Mirjam, Houot, Roch, Hudecek, Michael, Locatelli, Franco, Morgan, Kate, Morris, C. Emma, O’Dwyer, Michael, Gil, Jordi Sierra, van den Brink, Marcel, van de Loosdrecht, Arjan A., HAL UR1, Admin, University Hospital of Würzburg, Hospital de la Santa Creu i Sant Pau, IRCCS San Raffaele Scientific Institute [Milan, Italie], Leiden University Medical Center (LUMC), Departamento de Inteligencia Artificial [UPM, Spain] (DIA), Universidad Politécnica de Madrid (UPM), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Dana-Farber Cancer Institute [Boston], IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Royal Free Hospital [London, UK], National University of Ireland [Galway] (NUI Galway), Memorial Sloane Kettering Cancer Center [New York], VU University Medical Center [Amsterdam], Universiteit Leiden, Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
[SDV] Life Sciences [q-bio], Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, lcsh:RC633-647.5, [SDV]Life Sciences [q-bio], Perspective, HSCT, lcsh:Diseases of the blood and blood-forming organs, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

32. Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side

Author

Hudecek, M., Izsvák, Z., Johnen, S., Renner, M., Thumann, G., and Ivics, Z.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

Molecular medicine has entered a high-tech age that provides curative treatments of complex genetic diseases through genetically engineered cellular medicinal products. Their clinical implementation requires the ability to stably integrate genetic information through gene transfer vectors in a safe, effective and economically viable manner. The latest generation of Sleeping Beauty (SB) transposon vectors fulfills these requirements, and may overcome limitations associated with viral gene transfer vectors and transient non-viral gene delivery approaches that are prevalent in ongoing pre-clinical and translational research. The SB system enables high-level stable gene transfer and sustained transgene expression in multiple primary human somatic cell types, thereby representing a highly attractive gene transfer strategy for clinical use. Here we review several recent refinements of the system, including the development of optimized transposons and hyperactive SB variants, the vectorization of transposase and transposon as mRNA and DNA minicircles (MCs) to enhance performance and facilitate vector production, as well as a detailed understanding of SB's genomic integration and biosafety features. This review also provides a perspective on the regulatory framework for clinical trials of gene delivery with SB, and illustrates the path to successful clinical implementation by using, as examples, gene therapy for age-related macular degeneration (AMD) and the engineering of chimeric antigen receptor (CAR)-modified T cells in cancer immunotherapy.

Published
2017

33. Indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders : current practice in Europe, 2019

Author

Duarte, R.F., Labopin, M., Bader, P., Basak, G.W., Bonini, C., Chabannon, C., Corbacioglu, S., Dreger, P., Dufour, C., Genneryl, A.R., Kuball, J., Lankester, A.C., Lanza, F., Montoto, S., Nagler, A., Latour, R.P. de, Snowden, J.A., Styczynski, J., Yakoub-Agha, I., Kroger, N., Mohty, M., Albert, M., Alexander, T., Averbuch, D., Baron, F., Bazarbachi, E., Beksac, M., Brissot, E., Bug, G., Cesaro, S., Chalandon, Y., Ciceri, F., Czerw, T., Dazzi, F., Esteve, J., Fleischhauer, K., Garderet, L., Giebel, S., Gil, L., Gilleece, M., Gorin, N.C., Hayden, P., Halter, J., Boluda, J.C.H., Hudecek, M., Kleinschmidt, K., Kenyon, M., Koenecke, C., Locatelli, F., Malard, F., McLornan, D., Mikulska, M., Murray, J., Onida, F., Pedrazzoli, P., Penack, O., Peric, Z., Risitano, A., Robin, M., Robinson, S., Ruggeri, A., Sanz, J., Savani, B., Schetelig, J., Schied, C., Schmid, C., Schoemans, H., Schonland, S., Sharrack, B., Shouval, R., Spyridonidis, A., Toubert, A., Tourniac, O., Urbano-Ispizua, A., Vago, L., Gelder, M. van, Verhoeven, B., Versluis, J., Wietten, L., Willasch, A., European Soc Blood Marrow Transpla, Duarte, R. F., Labopin, M., Bader, P., Basak, G. W., Bonini, C., Chabannon, C., Corbacioglu, S., Dreger, P., Dufour, C., Gennery, A. R., Kuball, J., Lankester, A. C., Lanza, F., Montoto, S., Nagler, A., Peffault de Latour, R., Snowden, J. A., Styczynski, J., Yakoub-Agha, I., Kroger, N., Mohty, M, and on behalf of the European Society forBlood and Marrow Transplantation, (EBMT)

Subjects
medicine.medical_specialty, Transplantation Conditioning, medicine.medical_treatment, MEDLINE, Disease, Hematopoietic stem cell transplantation, History, 21st Century, NO, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, medicine, Humans, Intensive care medicine, Multiple myeloma, Accreditation, Transplantation, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, medicine.disease, Hematologic Diseases, Europe, Immune System Diseases, Hematologic disease, 030220 oncology & carcinogenesis, business, 030215 immunology
Abstract

This is the seventh special EBMT report on the indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders. Our aim is to provide general guidance on transplant indications according to prevailing clinical practice in EBMT countries and centres. In order to inform patient decisions, these recommendations must be considered together with the risk of the disease, the risk of the transplant procedure and the results of non-transplant strategies. In over two decades since the first report, the EBMT indications manuscripts have incorporated changes in transplant practice coming from scientific and technical developments in the field. In this same period, the establishment of JACIE accreditation has promoted high quality and led to improved outcomes of patient and donor care and laboratory performance in transplantation and cellular therapy. An updated report with operating definitions, revised indications and an additional set of data with overall survival at 1 year and non-relapse mortality at day 100 after transplant in the commonest standard-of-care indications is presented. Additional efforts are currently underway to enable EBMT member centres to benchmark their risk-adapted outcomes as part of the Registry upgrade Project 2020 against national and/or international outcome data.

Published
2019

39. General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial

Author

GALA Trial Collaborative Group, C Lewis, S, P Warlow, C, R Bodenham, A, Colam, B, M Rothwell, P, Torgerson, D, Dellagrammaticas, D, Horrocks, M, Liapis, C, P Banning, A, Gough, M, J Gough, M, Fraser, A, Grant, S, Hunter, J, Leigh-Brown, A, Paterson, M, Soosay, V, Young, A, Williamson, A, Dean, Z, Mazzoli, T, Ricci, S, Valenti, D, Bamford, J, Beard, J, Dearden, M, Murray, G, Ruckley, V, E Norman, P, Sedivy, P, Idla, A, Schmitz-Rixen, T, Maritati, G, Bodenham, A, Cokic, N, Doppler, W, Hlatky, P, Koelblinger, C, Raith, C, Zölss, C, Dimmitt, S, Gharbi, R, Hankey, G, Maden, A, P Mwipatayi, B, Sieunarine, K, Tan, A, Turner, G, Wesseldine, A, T M, E Davis, Audzei, P, Davidovski, I, Dedul, D, Hetsiuk, A, Kornievich, S, Gao, J, Y-G, Huang, Jing, G, H, Li, Y-J, Li, Liu, B, C-W, Liu, J-D, Wu, W, Ye, C-H, Yu, Ban, T, Buljan, K, Candrlic, K, Dapic, D, Ilijasevic, M, Istvanic, T, Kovac, B, Kvolik, S, Lehner, V, Pinotic, K, Hudorović, N, Ivanec, Z, Lovricević, I, Mazul-Sunko, B, Novotny, Z, D De Syo, Vuković, V, Biebl, O, Dolecek, L, C El Samman, Kalasova, H, Kubricht, V, Matous, P, Michalek, P, Stajnrt, M, Stern, M, Svec, M, Vitasek, P, Vrzal, J, Weiss, K, Janousek, L, Kieslichova, E, Mazarova, V, Piza, P, Vychodil, P, Dulovcova, V, Fiksa, J, Hruby, J, Maresch, M, Mathias, M, Rubes, D, Tosenovsky, P, Vidim, T, Henzl, M, Riman, J, Ziegler, Z, Drabek, P, Hrbac, T, Reguli, S, Stigler, J, Bachleda, P, Drac, P, Hudecek, M, Koutna, J, Sanak, D, Utikal, P, Goldemund, D, Gregor, Z, Pavlikova, J, Podlaha, J, Privara, M, Staffa, R, Vlachovsky, R, Barankova, L, Chlouba, V, Fiedler, J, Prazak, P, Priban, V, Wierer, A, Ellervee, T, Järve, H, Sell, A, Taba, P, Kolbassov, V, Kullamaa, S, Paavel, T, Abramishvili, N, Bokuchava, M, Kachapuridze, N, Kipiani, K, Papashvili, K, Pargalava, N, Adili, F, Dietz, A, Neidhart, G, Nentwig, G, M Sitzer, O, Beno, M, Essink-Hassels, M, Lander, K, Ruemenapf, G, Breuer, P, Heldt, R, Melichar, G, Rieper, J, H Eckstein, H, Poppert, H, Schneider, G, Andrikopoulos, V, Angel, A, Bakogiannis, K, Dermitzaki, M, Georgakis, P, Lioupis, C, Maras, D, G Moulakakis, K, Sfyroeras, G, Arato, E, Gyevnar, Z, Hardi, P, Kasza, G, Kollar, L, Menyhei, G, Pal, E, Sinay, L, Verzar, Z, Volgyi, E, S Elmakias, S, Harah, E, Kristal, K, Lebi, D, Leonty, Y, Levy, D, Milo, R, Yoffe, B, Bissi, M, Cappellini, B, Cassamali, T, Corino, L, Denkewitz, T, Ghilardi, G, Massetto, N, P Di Mauro, Tommasino, C, Bartolucci, R, Buffa, V, M Corsi, F, D'Avino, E, F Di Cesare, L Di Pirro, Lappa, A, Luzzi, S, Menichetti, A, Nesi, F, Pannone, A, Picozzi, P, Pogany, G, Rabitti, G, Severi, L, Avella, R, Biandolino, P, P Giomarelli, P, R Monfregola, M, Palasciano, G, Peccianti, V, Pieragalli, D, Setacci, C, Setacci, F, Sirignano, P, Bordoni, M, Casadei, V, Cugnasca, M, A De Troia, Geremia, L, Guffanti, P, G Lo Guercio, V Maniaci, M, Mauri, Morbidelli, A, Aletta, A, Costanzo, E, D'Arrigo, G, F Di Stefano, Lomeo, A, Maugeri, S, C Monea, M, Scardavilli, G, Scolaro, A, Aloisi, P, Ciccozzi, A, Manno, M, Marrelli, A, Martinazzo, C, Mastromarino, A, Petrassi, C, Piroli, A, Spartera, C, Ventura, M, Alessandrini, F, Carissimi, C, M Centritto, E, Cinelli, G, C De Filippo, Liberatoscioli, G, Modugno, P, Rossi, M, T Attanzio, M, Bajardi, G, Bellisi, M, Machi, P, Salemi, S, Savettieri, G, A Crea, M, V di Lazzaro, Ferrante, A, Guarneri, S, Manni, R, Snider, F, Stefanuto, C, Berardi, G, Bianchi, A, Comis, M, Cumbo, P, Fadde, M, Ferrero, E, Ferri, M, Filardo, A, Gaggiano, A, Ganzaroli, M, Labate, C, Maggio, D, Mennuti, G, Minicucci, S, Musso, A, Nessi, F, Pasquino, M, Perretta, L, Piazza, S, Verdecchia, C, Viazzo, A, Antico, A, Battan, E, Ciarlo, M, Giardini, G, G Luca Iob, Marinello, C, Piccolo, D, Bove, R, Castrucci, T, Lorido, A, Sammarco, S, Bruzzone, B, Cannata, D, Colotto, P, Finocchi, C, Giudici, N, Mambrini, S, Mazzei, R, Palombo, D, Pellegrino, A, Rousas, N, Viacava, A, Ermirio, D, Faga, D, Simoni, G, Benedetti-Valentini, F, Gabrielli, R, Garofano, R, Gossetti, B, Guerricchio, R, Irace, L, Lenzi, G, Gedins, M, Kisis, K, Krievins, D, Krustina, I, Lietuvietis, E, Malina, M, Morlata, N, Rits, J, Thor, S, Ivanova, P, Kikule, I, Liepa, V, Ligers, A, Stengrevica, N, Vnukova, N, Zvirgzdins, V, P J A, M Brouwers, H Geelkerken, R, Stam, A, M A, M Simon, T den Hoed, P, Oltmans, M, Rettig, H, F Veen, H, Zuidgeest, D, Feldo, M, Kesik, J, Kobusiewicz, W, Łatkiewicz, D, Myślinski, W, Przywara, S, Terlecki, P, Wroński, J, Zubilewicz, T, Alfonso, G, Azevedo, E, R de Albuquerque, Mansilha, A, Al-Salman, M, K Aldaif, A, A Alnasr, T, A El Dawlatly, A, Elkayali, A, M Rabee, H, Chudikova, E, Chudá, I, Dulka, T, Goldenberg, Z, Lofaj, P, Pavlikova, M, Pisar, M, Sefranek, V, Slysko, R, Tomka, J, Tóthová, Z, Zita, Z, A Cairols, M, Iborra, E, Mercadal, M, Rubio, F, Canovas, D, Cobo, L, Gimenez-Gaibar, A, Gonzalez, E, Gonzalo, B, Guilera, N, Hospedales, J, J Laso, M, Perez, J, Solanich, T, Hensater, M, Karlström, L, Kjällman, L, Rosengren, L, C-A, Ewaldsson, Gillgren, P, T-B, Käll, 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Mcilmoyle, J, Y Osman, H, Robinson, J, Chant, H, Mate, A, Sim, D, Upton, P, Thomas, D, H Wolfe, J, Mccollum, C, O'Neill, P, Bernatsky, V, Bondar, L, Karpenko, A, Mamonova, M, Muz, N, and Yavorsky, V

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Carotid endarterectomy, general anesthesia, local anesthesia, carotid surgery, Anesthesia, General, law.invention, Postoperative Complications, Randomized controlled trial, law, medicine, Humans, Carotid Stenosis, General anaesthesia, general anaesthesia, Stroke, Aged, Endarterectomy, Endarterectomy, Carotid, local anaesthesia, Intention-to-treat analysis, business.industry, General Medicine, Perioperative, Vascular surgery, medicine.disease, Surgery, Anesthesia, Female, business, Anesthesia, Local
Abstract

BACKGROUND: The effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia. METHODS: We undertook a parallel group, multicentre, randomised controlled trial of 3526 patients with symptomatic or asymptomatic carotid stenosis from 95 centres in 24 countries. Participants were randomly assigned to surgery under general (n=1753) or local (n=1773) anaesthesia between June, 1999 and October, 2007. The primary outcome was the proportion of patients with stroke (including retinal infarction), myocardial infarction, or death between randomisation and 30 days after surgery. Analysis was by intention to treat. The trial is registered with Current Control Trials number ISRCTN00525237. FINDINGS: A primary outcome occurred in 84 (4.8%) patients assigned to surgery under general anaesthesia and 80 (4.5%) of those assigned to surgery under local anaesthesia; three events per 1000 treated were prevented with local anaesthesia (95% CI -11 to 17; risk ratio [RR] 0.94 [95% CI 0.70 to 1.27]). The two groups did not significantly differ for quality of life, length of hospital stay, or the primary outcome in the prespecified subgroups of age, contralateral carotid occlusion, and baseline surgical risk. INTERPRETATION: We have not shown a definite difference in outcomes between general and local anaesthesia for carotid surgery. The anaesthetist and surgeon, in consultation with the patient, should decide which anaesthetic technique to use on an individual basis. FUNDING: The Health Foundation (UK) and European Society of Vascular Surgery.

Published
2008

40. Enhanced CAR T-cell engineering using non-viral Sleeping Beautytransposition from minicircle vectors

Author

Monjezi, R, Miskey, C, Gogishvili, T, Schleef, M, Schmeer, M, Einsele, H, Ivics, Z, and Hudecek, M

Abstract

Immunotherapy with T cell modified with gamma-retroviral or lentiviral (LV) vectors to express a chimeric antigen receptor (CAR) has shown remarkable efficacy in clinical trials. However, the potential for insertional mutagenesis and genotoxicity of viral vectors is a safety concern, and their cost and regulatory demands a roadblock for rapid and broad clinical translation. Here, we demonstrate that CAR T cells can be engineered through non-viral Sleeping Beauty(SB) transposition of CAR genes from minimalistic DNA vectors called minicircles (MCs). We analyzed genomic distribution of SB and LV integrations and show that a significantly higher proportion of MC-derived CAR transposons compared with LV integrants had occurred outside of highly expressed and cancer-related genes into genomic safe harbor loci that are not expected to cause mutagenesis or genotoxicity. CD19-CAR T cells engineered with our enhanced SB approach conferred potent reactivity in vitroand eradicated lymphoma in a xenograft model in vivo. Intriguingly, electroporation of SB MCs is substantially more effective and less toxic compared with conventional plasmids, and enables cost-effective rapid preparation of therapeutic CAR T-cell doses. This approach sets a new standard in advanced cellular and gene therapy and will accelerate and increase the availability of CAR T-cell therapy to treat hematologic malignancies.

Published
2017
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44. Double Lloyd's mirror: versatile instrument for XUV surface interferometry and interferometric microscopy

Author

Kozlova, M., primary, Rus, B., additional, Mocek, T., additional, Polan, J., additional, Stupka, M., additional, Prag, A., additional, Homer, P., additional, Hudecek, M., additional, Jamelot, G., additional, Lagron, J.C., additional, Cassou, K., additional, Ros, D., additional, Kazamias, S., additional, Klisnick, A., additional, Park, J.-J., additional, and Nam, C.-H., additional

Published
2005
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47. Chimeric antigen receptor-modified T cells derived from defined CD8+and CD4+subsets confer superior antitumor reactivity in vivo

Author

Sommermeyer, D, Hudecek, M, Kosasih, P L, Gogishvili, T, Maloney, D G, Turtle, C J, and Riddell, S R

Abstract

Adoptive T-cell therapy with gene-modified T cells expressing a tumor-reactive T-cell receptor or chimeric antigen receptor (CAR) is a rapidly growing field of translational medicine and has shown success in the treatment of B-cell malignancies and solid tumors. In all reported trials, patients have received T-cell products comprising random compositions of CD4+and CD8+naive and memory T cells, meaning that each patient received a different therapeutic agent. This variation may have influenced the efficacy of T-cell therapy, and complicates comparison of outcomes between different patients and across trials. We analyzed CD19 CAR-expressing effector T cells derived from different subsets (CD4+/CD8+naive, central memory, effector memory). T cells derived from each of the subsets were efficiently transduced and expanded, but showed clear differences in effector function and proliferation in vitroand in vivo. Combining the most potent CD4+and CD8+CAR-expressing subsets, resulted in synergistic antitumor effects in vivo. We show that CAR-T-cell products generated from defined T-cell subsets can provide uniform potency compared with products derived from unselected T cells that vary in phenotypic composition. These findings have important implications for the formulation of T-cell products for adoptive therapies.

Published
2016
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