900 results on '"Hubrecht Institute with UMC"'
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2. Cell division-dependent dissemination following E-cadherin loss underlies initiation of diffuse-type gastric cancer
3. Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools
4. Human Airway and Alveolar Organoids from BAL Fluid
5. Single-cell DNA sequencing reveals a high incidence of chromosomal abnormalities in human blastocysts
6. Primordial germ cell DNA demethylation and development require DNA translesion synthesis
7. Derivation of functional thymic epithelial organoid lines from adult murine thymus
8. Functional consequences of somatic polyploidy in development
9. Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin
10. Harzianic acid exerts antimicrobial activity against Gram-positive bacteria and targets the cell membrane
11. Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome
12. Human conjunctiva organoids to study ocular surface homeostasis and disease
13. Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms
14. Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase
15. Chromatin Remodeling in Patient-Derived Colorectal Cancer Models
16. p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice
17. From signalling oscillations to somite formation
18. Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer
19. Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response
20. Polyketide synthase positive Escherichia coli one-time measurement in stool is not informative of colorectal cancer risk in a screening setting
21. Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease
22. Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy
23. Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth
24. Single-Cell Histone Modification Profiling with Cell Enrichment Using sortChIC
25. Capturing embryonic hematopoiesis in temporal and spatial dimensions
26. Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families
27. Setting the stage for embryo segmentation
28. Vertebrate centromere architecture: from chromatin threads to functional structures
29. Standardizing designed and emergent quantitative features in microphysiological systems
30. The fork protection complex promotes parental histone recycling and epigenetic memory
31. Mechanisms that clear mutations drive field cancerization in mammary tissue
32. FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions
33. Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress
34. Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis
35. Centralized intestinal organoid generation is a feasible and safe approach for personalized medicine as demonstrated in the HIT-CF Europe Organoid Study
36. Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study
37. Combinatorial single-cell profiling of major chromatin types with MAbID
38. A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs
39. Urine-derived bladder cancer organoids (urinoids) as a tool for cancer longitudinal response monitoring and therapy adaptation
40. Protein Tyrosine Phosphatase Studies in Zebrafish
41. Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7
42. A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona
43. Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells
44. Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis
45. Zero-Mode Waveguide Nanowells for Single-Molecule Detection in Living Cells
46. DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints
47. Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss
48. Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology
49. Precise temporal control of neuroblast migration through combined regulation and feedback of a Wnt receptor
50. Precisely timed regulation of enhancer activity defines the binary expression pattern of Fushi tarazu in the Drosophila embryo
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