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Simple Summary: This study investigates the prognostic value of C-reactive protein (CRP) kinetics in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M-HNSCC) treated with checkpoint inhibitors (CPI). We analyzed data from 44 patients treated between 2018 and 2023, applying two existing CRP classifications and developing a new one. While the existing classifications did not correlate with overall survival (OS), our novel CRP kinetic classification showed a significant association with OS (p = 0.05). Multivariate analysis identified our CRP classification (p = 0.007) and the outcome of the first re-staging (p = 0.002) as independent prognostic factors. These findings suggest that our new CRP kinetic classification could serve as a valuable prognostic marker for R/M-HNSCC patients undergoing CPI therapy, though further validation with larger patient cohorts is needed. Introduction The kinetic of C-reactive protein (CRP) in the early phase of therapy with checkpoint inhibitors (CPI) and its prognostic value has already been investigated in several tumor entities. In particular, flare dynamics have been described as a positive prognostic parameter. The aim of this retrospective study is to examine the extent to which such an application can also be transferred to patients with recurrent or metastatic squamous cell carcinoma of the head and neck region (R/M-HNSCC). Material and Methods All patients treated with CPI for R/M-HNSCC at our clinic between 2018 and 2023 were included (n = 44). Demographic, clinical, histopathologic and laboratory data were extracted from the digital patient records and statistically analyzed. We then examined the CRP kinetic using two previously published classifications and proposed a new classification ourselves. Subsequently, correlation analyses were performed with the overall survival (OS) of the patients. Results Of the two CRP kinetic classifications previously published, only one showed a correlation with the result of the first re-staging, and neither showed a correlation with the OS of R/M-HNSCC patients. Our new CRP kinetic classification showed a significant association with OS in R/M-HNSCC patients (p = 0.05). In a multivariate analysis, our CRP kinetic classification (p = 0.007) and the outcome of the first re-staging (p = 0.002) were significant independent factors for OS. Discussion Our novel CRP kinetic classification significantly correlates with OS in R/M-HNSCC patients, indicating a potential prognostic marker. Existing classifications from other cancer entities showed limited prognostic significance, emphasizing the need for tailored markers. For validation, however, testing on larger R/M-HNSCC patient collectives is necessary. [ABSTRACT FROM AUTHOR]

We combine the recent literature on issue competition with work on intra‐party heterogeneity to advance a novel theoretical argument. Starting from the premise that party leaders and non‐leaders have different motivations and incentives, we conjecture that issue strategies should vary across the party hierarchy. We, therefore, expect systematic intra‐party differences in the use of riding the wave and issue ownership strategies. We test this claim by linking public opinion data to manually coded information on over 3600 press releases issued by over 500 party actors across five election campaigns in Austria between 2006 and 2019. We account for self‐selection into leadership roles by exploiting transitions into and out of leadership status over time. The results show that party leaders are more likely than non‐leaders to respond to the public's issue priorities, but not more or less likely to pursue issue‐ownership strategies. [ABSTRACT FROM AUTHOR]

Extant research points to the importance of social identity and group attitudes for political behavior. Even though this should have important consequences for political communication, few scholars have investigated how parties use appeals to social groups to capitalize on these predispositions. This study introduces the concept of social group yield as a new theoretical framework to explain how parties strategically emphasize groups to mobilize their core voters and broaden their support base among the general electorate. Empirically, I examine the case of Austria based on a content analysis of electoral manifestos for the national elections in 2013, 2017, and 2019 to measure parties' group emphasis, combined with cross-sectional survey data measuring voters' group attitudes. The results confirm that group attitudes of party supporters and the wider electorate direct parties' emphasis of different groups. These findings have important implications for the representation of social groups, political polarization, and party competition. [ABSTRACT FROM AUTHOR]