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9. Bioactive adrenomedullin and interleukin-6 in COVID-19: potential biomarkers of acute kidney injury and critical illness

Author

Leininger, Simon B., primary, Staudner, Stephan T., additional, Vogel, Manuel J., additional, Mustroph, Julian, additional, Hubauer, Ute, additional, Wallner, Stefan, additional, Lehn, Petra, additional, Burkhardt, Ralph, additional, Meindl, Christine, additional, Hanses, Frank, additional, Zimmermann, Markus, additional, Maier, Lars S., additional, Hupf, Julian, additional, and Jungbauer, Carsten G., additional

Published
2024
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11. Restoration of von Willebrand factor after transcatheter aortic valve replacement—A possible cause for posttranscatheter aortic valve replacement thrombocytopenia?

Author

Roth, Nastasia, primary, Heidel, Carolin, additional, Xu, Congde, additional, Hubauer, Ute, additional, Wallner, Stefan, additional, Meindl, Christine, additional, Holzamer, Andreas, additional, Hilker, Michael, additional, Creutzenberg, Marcus, additional, Sossalla, Samuel, additional, Maier, Lars, additional, Jungbauer, Carsten, additional, and Debl, Kurt, additional

Published
2023
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12. A multilocus genetic risk score for obesity: Association with BMI and metabolic alterations in a cohort with severe obesity

Author

Sag, Sabine Julia Maria, primary, Mueller, Stephanie, additional, Wallner, Stefan, additional, Strack, Christina, additional, Hubauer, Ute, additional, Mohr, Margareta, additional, Zeller, Judith, additional, Loew, Thomas, additional, Rehli, Michael, additional, Wimmer, Julia, additional, Zimmermann, Martina Erika, additional, Maier, Lars Siegfried, additional, Fischer, Marcus, additional, and Baessler, Andrea, additional

Published
2023
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13. Urinary N-Terminal Pro-Brain Natriuretic Peptide Predicts Acute Kidney Injury and Severe Disease in COVID-19

Author

Vogel, Manuel Julian, Leininger, Simon B., Staudner, Stephan T., Hubauer, Ute, Wallner, Stefan, Mustroph, Julian, Hanses, Frank, Zimmermann, Markus, Lehn, Petra, Burkhardt, Ralph, Maier, Lars S., Hupf, Julian, and Jungbauer, Carsten G.

Subjects
ddc:610, 610 Medizin, COVID-19, N-terminal pro-brain natriuretic peptide, Acute kidney injury, Urinary biomarkers
Abstract

Introduction: The ongoing COVID-19 pandemic is placing an extraordinary burden on our health care system with its limited resources. Accurate triage of patients is necessary to ensure medical care for those most severely affected. In this regard, biomarkers could contribute to risk evaluation. The aim of this prospective observational clinical study was to assess the relationship between urinary N-terminal pro-brain natriuretic peptide (NT-proBNP) and acute kidney injury (AKI) as well as severe disease in patients with COVID-19. Methods: 125 patients treated with an acute respiratory infection in the emergency department of the University Hospital Regensburg were analyzed. These patients were divided into a COVID-19 cohort (n = 91) and a cohort with infections not caused by severe acute respiratory syndrome-coronavirus-2 (n = 34). NT-proBNP was determined from serum and fresh urine samples collected in the emergency department. Clinical endpoints were the development of AKI and a composite one consisting of AKI, intensive care unit admission, and in-hospital death. Results: 11 (12.1%) COVID-19 patients developed AKI during hospitalization, whereas 15 (16.5%) reached the composite endpoint. Urinary NT-proBNP was significantly elevated in COVID-19 patients who suffered AKI or reached the composite endpoint (each p < 0.005). In a multivariate regression analysis adjusted for age, chronic kidney disease, chronic heart failure, and arterial hypertension, urinary NT-proBNP was identified as independent predictor of AKI (p = 0.017, OR = 3.91 [CI: 1.28–11.97] per standard deviation [SD]), as well as of the composite endpoint (p = 0.026, OR 2.66 [CI: 1.13–6.28] per SD). Conclusion: Urinary NT-proBNP might help identify patients at risk for AKI and severe disease progression in COVID-19.

Published
2023

14. Urinary N-Terminal Pro-Brain Natriuretic Peptide Predicts Acute Kidney Injury and Severe Disease in COVID-19

Author

Vogel, Manuel Julian, primary, Leininger, Simon B, additional, Staudner, Stephan T, additional, Hubauer, Ute, additional, Wallner, Stefan, additional, Mustroph, Julian, additional, Hanses, Frank, additional, Zimmermann, Markus, additional, Lehn, Petra, additional, Burkhardt, Ralph, additional, Maier, Lars S, additional, Hupf, Julian, additional, and Jungbauer, Carsten G, additional

Published
2023
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15. Additional file 1 of Gender differences in cardiometabolic health and disease in a cross-sectional observational obesity study

Author

Strack, Christina, Behrens, Gundula, Sag, Sabine, Mohr, Margareta, Zeller, Judith, Lahmann, Claas, Hubauer, Ute, Loew, Thomas, Maier, Lars, Fischer, Marcus, and Baessler, Andrea

Abstract

Additional file 1: Table S1: Proportions of lifestyle factors in non-obese and obese study participants. Table S2: Unadjusted means of lipid, metabolic and inflammatory markers and their standard deviations in non-obese and in grade 1 to grade 3 obese study participants. Table S3: Unadjusted means of cardiovascular parameters and their standard deviations in non-obese and in grade 1 to grade 3 obese study participants.

Published
2022
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19. Cardiac MRI Based Left Ventricular Global Function Index: Association with Disease Severity in Patients with ICD for Secondary Prevention

Author

Schober, Andreas Leonhard, primary, Jungbauer, Carsten, additional, Poschenrieder, Florian, additional, Schober, Alexander Daniel, additional, Hubauer, Ute, additional, Keyser, Andreas, additional, Fredersdorf-Hahn, Sabine, additional, Debl, Kurt, additional, Maier, Lars S., additional, Sossalla, Samuel, additional, Buchner, Stefan, additional, and Üçer, Ekrem, additional

Published
2021
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23. Novel Implantable Cardioverter Defibrillator Programming With High Rate Cut-Off, Long Detection Intervals and Multiple Anti-Tachycardia Pacing Reduces Mortality

Author

Schober, Alexander Daniel, primary, Schober, Andreas Leonhard, additional, Hubauer, Ute, additional, Fredersdorf, Sabine, additional, Seegers, Joachim, additional, Keyser, Andreas, additional, Stadler, Stefan, additional, Birner, Christoph, additional, Maier, Lars, additional, Jungbauer, Carsten, additional, and Ücer, Ekrem, additional

Published
2021
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25. Decreased GLUT1/NHE1 RNA expression in whole blood predicts disease severity in patients with COVID‐19

Author

Mustroph, Julian, primary, Hupf, Julian, additional, Hanses, Frank, additional, Evert, Katja, additional, Baier, Maria J., additional, Evert, Matthias, additional, Meindl, Christine, additional, Wagner, Stefan, additional, Hubauer, Ute, additional, Pietrzyk, Gabriela, additional, Leininger, Simon, additional, Staudner, Stephan, additional, Vogel, Manuel, additional, Wallner, Stefan, additional, Zimmermann, Markus, additional, Sossalla, Samuel, additional, Maier, Lars S., additional, and Jungbauer, Carsten, additional

Published
2020
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27. N‐acety‐b‐D‐glucosaminidase: A potential biomarker for early detection of acute kidney injury in acute chest pain

Author

Kaufmann, Manuel, primary, Schlossbauer, Michael, additional, Hubauer, Ute, additional, Stadler, Stefan, additional, Fischer, Marcus, additional, Wallner, Stefan, additional, Hupf, Julian, additional, Zimmermann, Markus, additional, Orso, Evelyn, additional, Zeman, Florian, additional, Luchner, Andreas, additional, Maier, Lars, additional, and Jungbauer, Carsten, additional

Published
2019
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28. The role of the tubular biomarkers NAG, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in patients with chest pain before contrast media exposition

Author

Schlossbauer, Michael H, primary, Hubauer, Ute, additional, Stadler, Stefan, additional, Hupf, Julian, additional, Sag, Sabine, additional, Birner, Christoph, additional, Zimmermann, Markus, additional, Orso, Evelyn, additional, Fischer, Marcus, additional, Luchner, Andreas, additional, Maier, Lars S, additional, and Jungbauer, Carsten G, additional

Published
2019
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29. Decreased GLUT1/NHE1 RNA expression in whole blood predicts disease severity in patients with COVID‐19.

Author

Mustroph, Julian, Hupf, Julian, Hanses, Frank, Evert, Katja, Baier, Maria J., Evert, Matthias, Meindl, Christine, Wagner, Stefan, Hubauer, Ute, Pietrzyk, Gabriela, Leininger, Simon, Staudner, Stephan, Vogel, Manuel, Wallner, Stefan, Zimmermann, Markus, Sossalla, Samuel, Maier, Lars S., and Jungbauer, Carsten

Subjects
COVID-19 testing, GLUCOSE transporters, GENE expression
Abstract

Aims: We aimed to assess whether expression of whole‐blood RNA of sodium proton exchanger 1 (NHE1) and glucose transporter 1 (GLUT1) is associated with COVID‐19 infection and outcome in patients presenting to the emergency department with respiratory infections. Furthermore, we investigated NHE1 and GLUT1 expression in the myocardium of deceased COVID‐19 patients. Methods and results: Whole‐blood quantitative assessment of NHE1 and GLUT1 RNA was performed using quantitative PCR in patients with respiratory infection upon first contact in the emergency department and subsequently stratified by SARS‐CoV‐2 infection status. Assessment of NHE1 and GLUT1 RNA using PCR was also performed in left ventricular myocardium of deceased COVID‐19 patients. NHE1 expression is up‐regulated in whole blood of patients with COVID‐19 compared with other respiratory infections at first medical contact in the emergency department (control: 0.0021 ± 0.0002, COVID‐19: 0.0031 ± 0.0003, P = 0.01). The ratio of GLUT1 to NHE1 is significantly decreased in the blood of COVID‐19 patients who are subsequently intubated and/or die (severe disease) compared with patients with moderate disease (moderate disease: 0.497 ± 0.083 vs. severe disease: 0.294 ± 0.0336, P = 0.036). This ratio is even further decreased in the myocardium of patients who deceased from COVID‐19 in comparison with the myocardium of non‐infected donors. Conclusions: NHE1 and GLUT1 may be critically involved in the disease progression of SARS‐CoV‐2 infection. We show here that SARS‐CoV‐2 infection critically disturbs ion channel expression in the heart. A decreased ratio of GLUT1/NHE1 could potentially serve as a biomarker for disease severity in patients with COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2021
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30. N-acety-b-D-glucosaminidase: A potential biomarker for early detection of acute kidney injury in acute chest pain.

Author

Kaufmann, Manuel, Schlossbauer, Michael, Hubauer, Ute, Stadler, Stefan, Fischer, Marcus, Wallner, Stefan, Hupf, Julian, Zimmermann, Markus, Orso, Evelyn, Zeman, Florian, Luchner, Andreas, Maier, Lars, and Jungbauer, Carsten

Subjects
ACUTE kidney failure, RECEIVER operating characteristic curves, MYOCARDIAL infarction, CONTRAST media, CHEST pain, RENAL tubular transport disorders
Abstract

Aim: Acute kidney injury (AKI) is often underdiagnosed due to several limitations of the renal marker creatinine. Tubular urinary biomarkers may substantially contribute to diagnose AKI early. For early detection of AKI, we evaluated for the first time Nacetyl- ß-D-glucosaminidase (NAG), Kidney-injury-molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in acute chest pain. Methods: We included 402 chest pain patients aged 18 to 95 years seen in the emergency department. From 311 subjects, blood and urine samples were collected. Results: Thirty-three patients developed an AKI and showed a significant increase in all three tubular markers compared to patients without AKI (each P < .001). According to receiver operating characteristic (ROC) analysis, combining NAG and creatinine showed a significantly increased area under the curve (AUC) compared to creatinine alone (AUC: 0.75 vs 0.87; P < .001). KIM-1, NGAL and cystatin C showed no significant differences in AUC compared to creatinine. In 120 individuals with blood and urine sampling before contrast media exposure, ROC analysis showed a significantly improved diagnostic performance for the combination of both (AUC: 0.83 vs creatinine AUC: 0.66; P = .004). AKI occurrence showed no dependency from CM volume. NAG presented as an independent AKI predictor beside creatinine, age, the diagnosis of myocardial infarction and mean arterial pressure. Regarding the prognostic value for renal replacement therapy, the combination of NAG and creatinine showed a significantly lager AUC than creatinine (AUC: 0.95 vs AUC: 0.85; P < .001). Conclusion: NAG presented as a promising marker of impending AKI and the necessity of renal replacement therapy. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Radiotherapie von Patienten mit kardialen implantierbaren elektronischen Geräten entsprechend der DEGRO/DGK-Leitlinie – wird das Risiko für relevante Fehlfunktionen überschätzt?

Author

Steger, Felix, Hautmann, Matthias G., Süß, Christoph, Hubauer, Ute, Ücer, Ekrem, Maier, Lars, Kölbl, Oliver, and Jungbauer, Carsten

Abstract

Copyright of Strahlentherapie und Onkologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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32. Coronary Artery Ectasia Are Frequently Observed in Patients With Bicuspid Aortic Valves With and Without Dilatation of the Ascending Aorta

Author

Meindl, Christine, primary, Achatz, Birgit, additional, Huber, Deborah, additional, Baessler, Andrea, additional, Hubauer, Ute, additional, Meisinger, Christa, additional, Hengstenberg, Christian, additional, Erdmann, Jeanette, additional, Buchner, Stefan, additional, Maier, Lars, additional, Schunkert, Heribert, additional, Debl, Kurt, additional, and Fischer, Marcus, additional

Published
2016
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33. Abstract 19274: Coronary Artery Ectasia Are Frequently Observed in Patients With Bicuspid Aortic Valves With and Without Aneurysm of the Ascending Aorta

Author

Meindl, Christine, primary, Achatz, Birgit, additional, Huber, Deborah, additional, Hubauer, Ute, additional, Buchner, Stefan, additional, Debl, Kurt, additional, Fenk, Sabine, additional, Strack, Christina, additional, Hengstenberg, Christian, additional, Schunkert, Heribert, additional, Meisinger, Christa, additional, Maier, Lars, additional, Baessler, Andrea, additional, and Fischer, Marcus, additional

Published
2014
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