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6. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Author

Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie AM, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline SL, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, and Liu, Yongmei

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics
Abstract

A correction to this article has been published and is linked from the HTML version of this article.

Published
2017

7. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Author

Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie AM, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline SL, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, and Liu, Yongmei

Subjects
Humans, Thinness, 17-Hydroxysteroid Dehydrogenases, Aldehyde Oxidoreductases, Extracellular Matrix Proteins, Body Composition, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Regulatory Elements, Transcriptional, Versicans, Genome-Wide Association Study, Insulin Receptor Substrate Proteins, ADAMTS Proteins, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Human Genome, Genetics, 1.1 Normal biological development and functioning
Abstract

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p

Published
2017

9. Consumption of sucralose- and acesulfame-potassium-containing diet soda alters the relative abundance of microbial taxa at the species level: findings of two pilot studies

Author

Sylvetsky, Allison C., primary, Clement, Rebecca A., additional, Stearrett, Nathaniel, additional, Issa, Najy T., additional, Dore, Fiona J., additional, Mazumder, Raja, additional, King, Charles Hadley, additional, Hubal, Monica J., additional, Walter, Peter J., additional, Cai, Hongyi, additional, Sen, Sabyasachi, additional, Rother, Kristina I., additional, and Crandall, Keith A., additional

Published
2023
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10. Resistance Exercise Modifies Extracellular Vesicle Mirnas Targeting Gene Pathways Associated With Muscle Protein Metabolism

Author

Conkright, William R., primary, Hubal, Monica J., additional, Sterczala, Adam J., additional, Tiede, Dakota R., additional, Kargl, Chris K., additional, Beckner, Meaghan E., additional, Sahu, Amrita, additional, Krajewski, Kellen, additional, Martin, Brian J., additional, Flanagan, Shawn D., additional, Rodriguez, Nathaniel, additional, Van Eck, Carola F., additional, Wardle, Sophie L., additional, O'Leary, Thomas J., additional, Greeves, Julie P., additional, Ambrosio, Fabrisia, additional, and Nindl, Bradley C., additional

Published
2023
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13. Consumption of sucralose- and acesulfame-potassium-containing diet soda alters the relative abundance of microbial taxa at the species level: findings of two pilot studies.

Author

Sylvetsky, Allison C., Clement, Rebecca A., Stearrett, Nathaniel, Issa, Najy T., Dore, Fiona J., Mazumder, Raja, King, Charles Hadley, Hubal, Monica J., Walter, Peter J., Cai, Hongyi, Sen, Sabyasachi, Rother, Kristina I., and Crandall, Keith A.

Subjects
OBESITY, BEVERAGES, GUT microbiome, BACTEROIDES, WATER, DIABETES, SWEETENERS, DIETARY sucrose, ENTEROBACTERIACEAE, COMPARATIVE studies, CARBONATED beverages, RESEARCH funding, SECONDARY analysis, BACTERIA, ADIPOSE tissues, ADULTS
Abstract

Sucralose and acesulfame-potassium consumption alters gut microbiota in rodents, with unclear effects in humans. We examined effects of three-times daily sucralose- and acesulfame-potassium-containing diet soda consumption for 1 (n = 17) or 8 (n = 8) weeks on gut microbiota composition in young adults. After 8 weeks of diet soda consumption, the relative abundance of Proteobacteria, specifically Enterobacteriaceae, increased; and, increased abundance of two Proteobacteria taxa was also observed after 1 week of diet soda consumption compared with sparkling water. In addition, three taxa in the Bacteroides genus increased following 1 week of diet soda consumption compared with sparkling water. The clinical relevance of these findings and effects of sucralose and acesulfame-potassium consumption on human gut microbiota warrant further investigation in larger studies. Clinical trial registration: NCT02877186 and NCT03125356. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Introduction

Author

Lightfoot, J. Timothy, primary, Hubal, Monica J., additional, and Roth, Stephen M., additional

Published
2019
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37. Additional file 1 of Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis

Author

Andonian, Brian J., Johannemann, Andrew, Hubal, Monica J., Pober, David M., Koss, Alec, Kraus, William E., Bartlett, David B., and Huffman, Kim M.

Abstract

Additional file 1: Supplementary Table 1. Cross-sectional rheumatoid arthritis cohort #1 top skeletal muscle genes. Supplementary Table 2. Cross-sectional rheumatoid arthritis cohort #1: Skeletal muscle canonical pathways associated with disease activity. Supplementary Table 3. High-intensity interval training rheumatoid arthritis cohort #2 top skeletal muscle genes associated with improvements in disease activity. Supplementary Table 4. High-intensity interval training rheumatoid arthritis cohort #2: Skeletal muscle canonical pathways associated with improvements in disease activity.

Published
2021
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39. Altered Skeletal Muscle Metabolic Pathways, Age, Systemic Inflammation, and Low Cardiorespiratory Fitness Associate with Improvements in Disease Activity Following High-Intensity Interval Training in Persons with Rheumatoid Arthritis

Author

Andonian, Brian J., primary, Johannemann, Andrew, additional, Hubal, Monica J., additional, Pober, David M., additional, Koss, Alec, additional, Kraus, William E., additional, Bartlett, David B., additional, and Huffman, Kim M., additional

Published
2021
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40. SLC30A8 nonsynonymous variant is associated with recovery following exercise and skeletal muscle size and strength

Author

Sprouse, Courtney, Gordish-Dressman, Heather, Orkunoglu-Suer, E. Funda, Lipof, Jason S., Moeckel-Cole, Stephanie, Patel, Ronak R., Adham, Kasra, Larkin, Justin S., Hubal, Monica J., Kearns, Amy K., Clarkson, Priscilla M., Thompson, Paul D., Angelopoulos, Theodore J., Gordon, Paul M., Moyna, Niall M., Pescatello, Linda S., Visich, Paul S., Zoeller, Robert F., Hoffman, Eric P., Tosi, Laura L., and Devaney, Joseph M.

Subjects
Muscle strength -- Physiological aspects -- Health aspects -- Genetic aspects, Medical genetics -- Research, Isometric exercise -- Physiological aspects -- Health aspects -- Genetic aspects, Single nucleotide polymorphisms -- Health aspects, Type 2 diabetes -- Genetic aspects -- Risk factors, Allelomorphism -- Health aspects, Muscles -- Physiological aspects -- Health aspects -- Genetic aspects, Health
Abstract

Genome-wide association studies have identified thousands of variants that are associated with numerous phenotypes. One such variant, rs13266634, a nonsynonymous single nucleotide polymorphism in the solute carrier family 30 (zinc transporter) member eight gene, is associated with a 53% increase in the risk of developing type 2 diabetes (T2D). We hypothesized that individuals with the protective allele against T2D would show a positive response to short-term and long-term resistance exercise. Two cohorts of young adults--the Eccentric Muscle Damage (EMD; n = 156) cohort and the Functional Single Nucleotide Polymorphisms Associated with Muscle Size and Strength Study (FAMuSS; n = 874)--were tested for association of the rs13266634 variant with measures of skeletal muscle response to resistance exercise. Our results were sexually dimorphic in both cohorts. Men in the EMD study with two copies of the protective allele showed less post-exercise bout strength loss, less soreness, and lower creatine kinase values. In addition, men in the FAMuSS, homozygous for the protective allele, showed higher pre-exercise strength and larger arm skeletal muscle volume, but did not show a significant difference in skeletal muscle hypertrophy or strength with resistance training. Diabetes 2014;63:363-368 | DOI: 10.2337/db13-1150, Genome-wide association studies (GWASs) are extensively used as a tool to discover common single nucleotide polymorphisms (SNPs) associated with complex disease phenotypes such as type 2 diabetes (T2D), dyslipidemia, and [...]

Published
2014
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41. Response to Comment on Sprouse et al. SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength. Diabetes 2014;63: 363–368

Author

Sprouse, Courtney, Gordish-Dressman, Heather, Orkunoglu-Suer, E. Funda, Lipof, Jason S., Moeckel-Cole, Stephanie, Patel, Ronak R., Adham, Kasra, Larkin, Justin S., Hubal, Monica J., Kearns, Amy K., Clarkson, Priscilla M., Thompson, Paul D., Angelopoulos, Theodore J., Gordon, Paul M., Moyna, Niall M., Pescatello, Linda S., Visich, Paul S., Zoeller, Robert F., Hoffman, Eric P., Tosi, Laura L., and Devaney, Joseph M.

Published
2014
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43. Is physical activity regulated by genetics?

Author

Van Der Zee, Matthijs D., De Geus, Eco, Lightfoot, J. Timothy, Hubal, Monica J., Roth, Stephen M., Biological Psychology, APH - Personalized Medicine, APH - Mental Health, Lightfoot, J. Timothy, Hubal, Monica J., and Roth, Stephen M.

Subjects
Family member, SDG 3 - Good Health and Well-being, Offspring, Physical activity, Family aggregation, Common denominator, Psychology, Human behavior, Set (psychology), Twin study, Developmental psychology
Abstract

Physical activity (PA) is a broad concept containing a variety of different human behaviors that share the common denominator of expected beneficial effects on mental and somatic health. PA behaviors appear to "run in the family" for example, the chance of one family member being a regular exerciser increases the chance of all other family members to be, or to become, an exerciser. Familial aggregation of PA can be investigated by computing correlations among relatives such as siblings, and parents and their offspring. In the final set of 27 adult twin studies, we encountered a large variation in measurement instruments and PA measures used. By far the largest common denominator was the use of survey-based methods using subjective PA reporting on self or family members. In large population-based twin registries, surveys are often considered the only feasible strategy.

Published
2019

44. Muscle function in men and women during maximal eccentric exercise

Author

Hubal, Monica J., Rubinstein, Scott R., and Clarkson, Priscilla M.

Subjects
Muscle strength -- Research, Fatigue -- Observations, Health, Sports and fitness
Abstract

This study assessed muscle fatigue patterns of the elbow flexors in untrained men and women to determine if sex differences exist during acute maximal eccentric exercise. High-intensity eccentric exercise is often used by athletes to elicit gains in muscle strength and size gains. Development of fatigue during this type of exercise can increase risk of injury; therefore, it is important to understand fatigue patterns during eccentric exercise to minimize injury risk exposure while still promoting training effects. While many isometric exercise studies have demonstrated that women show less fatigue, the patterns of fatigue during purely eccentric exercise have not been assessed in men and women. Based on the lack of sex differences in overall strength loss immediately post-eccentric exercise, it was hypothesized that women and men would have similar relative fatigue pattern responses (i.e., change from baseline) during a single bout of maximal eccentric exercise. Forty-six subjects (24 women and 22 men) completed 5 sets of 10 maximal eccentric contractions on an isokinetic dynamometer. Maximal voluntary isometric contraction strength was assessed at baseline and immediately following each exercise set. Maximal eccentric torque and contractile properties (i.e., contraction time, work, half relaxation time, and maximal rate of torque development) were calculated for each contraction. Men and women demonstrated similar relative isometric (32% for men and 39% for women) and eccentric (32% for men and 39% for women) fatigue as well as similar deficits in work done and rates of torque development and relaxation during exercise (p > 0.05).Untrained men and women displayed similar relative responses in all measures of muscle function during a single bout of maximal eccentric exercise of the elbow flexors. Thus, there is no reason to suspect that women may be more vulnerable to fatigue-related injury. KEY WORDS sex differences, muscle fatigue, strength loss peak torque, work

Published
2008

45. Inflammatory gene changes associated with the repeated-bout effect

Author

Hubal, Monica J., Chen, Trevor C., Thompson, Paul D., and Clarkson, Priscilla M.

Subjects
Inflammation -- Evaluation, Gene expression -- Evaluation, Diagnostic immunohistochemistry -- Research, Biological sciences
Abstract

This study proposed that attenuated expression of inflammatory factors is an underlying mechanism driving the repeated-bout effect (rapid adaptation to eccentric exercise). We investigated changes in mRNA levels and protein localization of inflammatory genes after two bouts of muscle-lengthening exercise. Seven male subjects performed two bouts of lower body exercise (separated by 4 wk) in which one leg performed 300 eccentric-concentric actions, and the contralateral leg performed 300 concentric actions only. Vastus lateralis biopsies were collected at 6 h, and strength was assessed at baseline and at 0, 3, and 5 days after exercise, mRNA levels were measured via semiquantitative RT-PCR for the following genes: CYR61, HSP40, HSP70, IL1R1, TCF8, ZFP36, CEBPD, and MCPI. Muscle functional adaptation was demonstrated via attenuated strength loss (16% less, P = 0.04) at 5 days after bout 2 compared with bout 1 in the eccentrically exercised leg. mRNA expression of three of the eight genes tested was significantly elevated in the eccentrically exercised leg from bout 1 to bout 2 (+3.9-fold for ZFP36, +2.3-fold for CEBPD, and +2.6-fold for MCPI), while all eight mRNA levels were unaffected by bout in the concentrically exercised leg. Immunohistochemistry further localized the protein of one of the elevated factors [monocyte chemoattractant protein-1 (MCP1)] within the tissue. MCP1 colocalized with resident macrophage and satellite cell populations, suggesting that alterations in cytokine signaling between these cell populations may play a role in muscle adaptation to exercise. Contrary to our hypothesis, several inflammatory genes were transcriptionally upregulated (rather than attenuated) after a repeated exercise bout, potentially indicating a role for these genes in the adaptation process. muscle damage: immunohistochemistry; repair

Published
2008

49. Consumption of Diet Soda Sweetened with Sucralose and Acesulfame‐Potassium Alters Inflammatory Transcriptome Pathways in Females with Overweight and Obesity

Author

Sylvetsky, Allison C., primary, Sen, Sabyasachi, additional, Merkel, Patrick, additional, Dore, Fiona, additional, Stern, David B., additional, Henry, Curtis J., additional, Cai, Hongyi, additional, Walter, Peter J., additional, Crandall, Keith A., additional, Rother, Kristina I., additional, and Hubal, Monica J., additional

Published
2020
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